http://togogenome.org/gene/9541:PKD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VH75 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:CXXC5 ^@ http://purl.uniprot.org/uniprot/I7GIK3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:SLC6A14 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9541:PRKAB1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XCL8|||http://purl.uniprot.org/uniprot/G7PIT4 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/9541:IMP4 ^@ http://purl.uniprot.org/uniprot/A0A7N9CN51 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9541:EIF2S2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5I2|||http://purl.uniprot.org/uniprot/Q4R5G5 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/9541:GPHB5 ^@ http://purl.uniprot.org/uniprot/A0A7N9IDV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9541:MEGF10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VD65 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:TBC1D23 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTW2|||http://purl.uniprot.org/uniprot/A0A2K5UTY6|||http://purl.uniprot.org/uniprot/A0A2K5UU06|||http://purl.uniprot.org/uniprot/A0A8J8XGF9|||http://purl.uniprot.org/uniprot/G7NZ86 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/9541:LCMT1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CBY8|||http://purl.uniprot.org/uniprot/A0A7N9CIE3|||http://purl.uniprot.org/uniprot/A0A7N9IAE8|||http://purl.uniprot.org/uniprot/I7GA68 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. LCMT family.|||Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. http://togogenome.org/gene/9541:GABRA6 ^@ http://purl.uniprot.org/uniprot/G7P6T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:GALK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGN0 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/9541:PKN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQ73|||http://purl.uniprot.org/uniprot/A0A8J8YH34|||http://purl.uniprot.org/uniprot/G7NTM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cleavage furrow|||Midbody|||Nucleus http://togogenome.org/gene/9541:SEMA5A ^@ http://purl.uniprot.org/uniprot/A0A2K5WPX8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:RPL18 ^@ http://purl.uniprot.org/uniprot/Q4R5H8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL18 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/9541:CHM ^@ http://purl.uniprot.org/uniprot/A0A2K5VYT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. http://togogenome.org/gene/9541:XPNPEP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNK8 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/9541:BCO2 ^@ http://purl.uniprot.org/uniprot/Q8HXG8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit.|||Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids. Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta-cryptoxanthin at both the 9,10 and the 9',10' carbon-carbon double bond. Through its function in carotenoids metabolism regulates oxidative stress and the production of important signaling molecules.|||Mitochondrion http://togogenome.org/gene/9541:LOC102122149 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y9Z4|||http://purl.uniprot.org/uniprot/G7P524 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9541:PSMD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKI2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S2 family.|||Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9541:MEIS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2K1|||http://purl.uniprot.org/uniprot/A0A2K5U2L5|||http://purl.uniprot.org/uniprot/A0A2K5U2L9|||http://purl.uniprot.org/uniprot/A0A2K5U2N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9541:ATP1B1 ^@ http://purl.uniprot.org/uniprot/Q4R4V5 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the X(+)/potassium ATPases subunit beta family.|||Cell membrane|||Glutathionylated (By similarity). N-glycosylated (By similarity).|||Involved in cell adhesion and establishing epithelial cell polarity.|||The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.|||The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with catalytic subunit ATP12A (By similarity). Interacts with regulatory subunit FXYD1 (By similarity). Interacts with regulatory subunit FXYD3 (By similarity). Interacts with NKAIN1, NKAIN2 and NKAIN4 (By similarity). Interacts with MLC1. Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM. Interacts with KIRREL3 (By similarity). Interacts with OBSCN (via protein kinase domain 1) (By similarity). Interacts with TRAF3 and TRAF6 (By similarity).|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1.|||sarcolemma http://togogenome.org/gene/9541:CNTFR ^@ http://purl.uniprot.org/uniprot/A0A2K5WIH9 ^@ Similarity ^@ Belongs to the type I cytokine receptor family. Type 3 subfamily. http://togogenome.org/gene/9541:GDPD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIT9 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9541:SLC30A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W895 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9541:CFL2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YPP2|||http://purl.uniprot.org/uniprot/G7PA25 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/9541:SNCG ^@ http://purl.uniprot.org/uniprot/G7PEV7|||http://purl.uniprot.org/uniprot/Q2PFW6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synuclein family.|||May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.|||Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases (By similarity).|||Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).|||centrosome|||perinuclear region|||spindle http://togogenome.org/gene/9541:VPS4B ^@ http://purl.uniprot.org/uniprot/A0A2K5VZL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9541:KCNK13 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPH6|||http://purl.uniprot.org/uniprot/G7PB58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9541:PDE1C ^@ http://purl.uniprot.org/uniprot/A0A2K5WRJ8|||http://purl.uniprot.org/uniprot/A0A2K5WRL9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:SPATA18 ^@ http://purl.uniprot.org/uniprot/Q95K37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MIEAP family.|||Cytoplasm|||Interacts (via coiled-coil domains) with BNIP3L (via BH3 domain). Interacts (via coiled-coil domains) with BNIP3 (via BH3 domain).|||Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity).|||Mitochondrion outer membrane http://togogenome.org/gene/9541:CHRM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULM2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/9541:PHACTR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WI24|||http://purl.uniprot.org/uniprot/I7GKZ0 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/9541:YWHAG ^@ http://purl.uniprot.org/uniprot/A0A2K5WMN9 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9541:SGF29 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKH8|||http://purl.uniprot.org/uniprot/Q4R7C7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FBN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TS66 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fibrillin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:DNM1L ^@ http://purl.uniprot.org/uniprot/A0A2K5UCX1|||http://purl.uniprot.org/uniprot/A0A2K5UCX6|||http://purl.uniprot.org/uniprot/A0A2K5UD34|||http://purl.uniprot.org/uniprot/Q4R5H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.|||Endomembrane system|||Golgi apparatus|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||clathrin-coated pit|||cytosol|||synaptic vesicle membrane http://togogenome.org/gene/9541:CEP44 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9Y3|||http://purl.uniprot.org/uniprot/Q4R7I0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall. Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome.|||Interacts with CROCC. Interacts with POC1B; the interaction is direct and recruits POC1B to centriolar microtubules. Binds to centriolar microtubules.|||Midbody|||centriole|||centrosome|||spindle pole http://togogenome.org/gene/9541:ASPH ^@ http://purl.uniprot.org/uniprot/A0A2K5UVU0|||http://purl.uniprot.org/uniprot/A0A2K5UVW6|||http://purl.uniprot.org/uniprot/A0A2K5UVW8|||http://purl.uniprot.org/uniprot/A0A2K5UW09|||http://purl.uniprot.org/uniprot/A0A2K5UW10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartyl/asparaginyl beta-hydroxylase family.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9541:GPN1 ^@ http://purl.uniprot.org/uniprot/I7GH38 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II.|||Cytoplasm|||Nucleus|||Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9541:APOC1 ^@ http://purl.uniprot.org/uniprot/P18657 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. The two genes for ApoC-I arose through a duplication process that occurred after the divergence of New World monkeys from the human lineage. In human, the acidic form has become a pseudogene sometime between the divergence of bonobos and chimpanzees from the human lineage and the appearance of the Denisovans. Pseudogenization resulted when the codon for the penultimate amino acid in the signal sequence was changed to a stop codon.|||Belongs to the apolipoprotein C1 family.|||Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.|||Secreted http://togogenome.org/gene/9541:CASC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWK0|||http://purl.uniprot.org/uniprot/A0A2K5WWN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CASC3 family.|||Nucleus speckle|||dendrite|||perinuclear region http://togogenome.org/gene/9541:AGTR1 ^@ http://purl.uniprot.org/uniprot/G7NZZ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. http://togogenome.org/gene/9541:ATP5F1E ^@ http://purl.uniprot.org/uniprot/A0A2K5UDE9 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ATPase epsilon family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/9541:MUTYH ^@ http://purl.uniprot.org/uniprot/A0A2K5UK75|||http://purl.uniprot.org/uniprot/A0A2K5UK92|||http://purl.uniprot.org/uniprot/Q4R343 ^@ Cofactor|||Function|||Similarity ^@ Adenine glycosylase active on G-A mispairs.|||Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/9541:VWC2L ^@ http://purl.uniprot.org/uniprot/A0A2K5UC09|||http://purl.uniprot.org/uniprot/A0A8J8YL83|||http://purl.uniprot.org/uniprot/G7PLD0 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/9541:VEGFA ^@ http://purl.uniprot.org/uniprot/A0A7N9CDP5|||http://purl.uniprot.org/uniprot/A0A7N9IDA9|||http://purl.uniprot.org/uniprot/Q95NE5 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9541:TMTC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7C9|||http://purl.uniprot.org/uniprot/A0A2K5V7E7|||http://purl.uniprot.org/uniprot/A0A7N9IGR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9541:ST6GALNAC6 ^@ http://purl.uniprot.org/uniprot/G8F557 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:ZKSCAN8 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTZ8|||http://purl.uniprot.org/uniprot/G7P3S3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LIPF ^@ http://purl.uniprot.org/uniprot/A0A2K5VBR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9541:LOC102129682 ^@ http://purl.uniprot.org/uniprot/Q4R4K6 ^@ Function|||PTM|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family.|||Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity).|||Mono-ADP-ribosylation at Glu-35 by PARP16 inhibits polysome assembly and mRNA loading, thereby inhibiting protein translation.|||Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the pre-initiation complex.|||Specifically hydroxylated (with R stereochemistry) at C-3 of Arg-137 by KDM8. http://togogenome.org/gene/9541:DYNC2H1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLY8|||http://purl.uniprot.org/uniprot/A0A2K5TLZ0 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/9541:ZNF711 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5G0|||http://purl.uniprot.org/uniprot/A0A8J8YJG0|||http://purl.uniprot.org/uniprot/G7Q360 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:OLA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKG4|||http://purl.uniprot.org/uniprot/I7GJA8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.|||Cytoplasm|||Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.|||Monomer.|||Nucleus|||nucleolus http://togogenome.org/gene/9541:RBKS ^@ http://purl.uniprot.org/uniprot/A0A8J8XKD9|||http://purl.uniprot.org/uniprot/G7PLX7 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Nucleus|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/9541:FMO2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VS71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9541:AQP9 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y8Y4|||http://purl.uniprot.org/uniprot/G7PBK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9541:ESYT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WF44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the extended synaptotagmin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:SUSD4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIA2|||http://purl.uniprot.org/uniprot/A0A2K5VIB5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:GRK5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7B6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9541:NKD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WT32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NKD family.|||Cell autonomous antagonist of the canonical Wnt signaling pathway.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:SLC4A10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSF0|||http://purl.uniprot.org/uniprot/A0A2K5WSS1|||http://purl.uniprot.org/uniprot/A0A2K5WSW5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:RDX ^@ http://purl.uniprot.org/uniprot/I7G8X5 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9541:NRM ^@ http://purl.uniprot.org/uniprot/A0A2K5X7A8|||http://purl.uniprot.org/uniprot/A0A7N9IHG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nurim family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9541:GPR83 ^@ http://purl.uniprot.org/uniprot/A0A7N9CN28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9541:PIGV ^@ http://purl.uniprot.org/uniprot/A0A2K5WCU5|||http://purl.uniprot.org/uniprot/G8F2H1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGV family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.|||Membrane http://togogenome.org/gene/9541:MON2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5N9|||http://purl.uniprot.org/uniprot/A0A2K5X5Q0 ^@ Similarity ^@ Belongs to the MON2 family. http://togogenome.org/gene/9541:MON1B ^@ http://purl.uniprot.org/uniprot/A0A2K5WX47|||http://purl.uniprot.org/uniprot/Q4R4E4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MON1/SAND family.|||Interacts with CCNT2; down-regulates CCNT2-mediated activation of viral promoters during herpes simplex virus 1/HHV-1 infection. Found in a complex with RMC1, CCZ1 MON1A and MON1B.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/9541:SLC13A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9541:SETD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBQ1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.|||Cytoplasm|||Interacts with MYOD1. http://togogenome.org/gene/9541:KCTD14 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5I7|||http://purl.uniprot.org/uniprot/G7PNB4 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:SCFD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X101 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9541:SPESP1 ^@ http://purl.uniprot.org/uniprot/G7P8X6|||http://purl.uniprot.org/uniprot/Q95LJ2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPESP1 family.|||Glycosylated. In testis there are two predominant forms of 77- and 67-kDa and a form of 47-kDa, whereas in epididymal sperm from caput, corpus, and cauda there are two forms of 47- and 43-kDa. Testis forms contain complex carbohydrate residues. Epididymal sperm forms are N-glycosylated. Then undergoes significant glycosylation in the testis and that the majority of these glycoconjugates are removed by the time sperm reach the caput epididymis.|||Involved in fertilization ability of sperm.|||acrosome http://togogenome.org/gene/9541:FAM120B ^@ http://purl.uniprot.org/uniprot/A0A2K5TS44 ^@ Similarity ^@ Belongs to the constitutive coactivator of PPAR-gamma family. http://togogenome.org/gene/9541:ELAPOR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELAPOR family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:KCNK9 ^@ http://purl.uniprot.org/uniprot/A0A7N9DCV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane|||pH-dependent, voltage-insensitive, background potassium channel protein. http://togogenome.org/gene/9541:HOXB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U427 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:BCL2A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMD8 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9541:AHDC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UC45 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PGK1 ^@ http://purl.uniprot.org/uniprot/G7Q337|||http://purl.uniprot.org/uniprot/Q60HD8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9541:NTN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJQ8|||http://purl.uniprot.org/uniprot/A0A2K5TJR4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:SCMH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3Q4|||http://purl.uniprot.org/uniprot/A0A2K5W3S2|||http://purl.uniprot.org/uniprot/A0A2K5W3U6|||http://purl.uniprot.org/uniprot/A0A2K5W3U7|||http://purl.uniprot.org/uniprot/A0A8J8YP52|||http://purl.uniprot.org/uniprot/Q4R8H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/9541:GCNT4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCK1|||http://purl.uniprot.org/uniprot/G7P7R4 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:NUP210 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMY5 ^@ Similarity ^@ Belongs to the NUP210 family. http://togogenome.org/gene/9541:DOCK8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UG46|||http://purl.uniprot.org/uniprot/A0A2K5UG61|||http://purl.uniprot.org/uniprot/A0A2K5UG74 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9541:ECE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFW0 ^@ Function ^@ Converts big endothelin-1 to endothelin-1. http://togogenome.org/gene/9541:LRP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUP5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LDLR family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:INHBE ^@ http://purl.uniprot.org/uniprot/A0A8J8YNK9|||http://purl.uniprot.org/uniprot/G7PIV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9541:ACTC1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YL82|||http://purl.uniprot.org/uniprot/G7PAP7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:ZIC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKM4|||http://purl.uniprot.org/uniprot/G7Q1T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLI C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9541:CEP70 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLP6|||http://purl.uniprot.org/uniprot/Q4R7V1 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.|||Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle (By similarity).|||Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.|||The coiled-coil domains may be important for tubulin-gamma-binding and hence for centrosomal localization.|||centrosome http://togogenome.org/gene/9541:TMED4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAI8|||http://purl.uniprot.org/uniprot/A0A7N9D1Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:KMT2C ^@ http://purl.uniprot.org/uniprot/A0A2K5WSE5|||http://purl.uniprot.org/uniprot/A0A2K5WSR2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PROM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIL3|||http://purl.uniprot.org/uniprot/A0A2K5VIM1|||http://purl.uniprot.org/uniprot/A0A2K5VIM5|||http://purl.uniprot.org/uniprot/A0A2K5VIQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/9541:MFSD6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQX5|||http://purl.uniprot.org/uniprot/A0A7N9CQR8|||http://purl.uniprot.org/uniprot/G7PL19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. MFSD6 family.|||Membrane http://togogenome.org/gene/9541:STEAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1J3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TFAP2A ^@ http://purl.uniprot.org/uniprot/A0A2K5WXI6|||http://purl.uniprot.org/uniprot/A0A2K5WXM2|||http://purl.uniprot.org/uniprot/A0A2K5WXN6|||http://purl.uniprot.org/uniprot/A0A2K5WY41|||http://purl.uniprot.org/uniprot/A0A2K5WY51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AP-2 family.|||Nucleus http://togogenome.org/gene/9541:GREM2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CTP7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:ANKRD53 ^@ http://purl.uniprot.org/uniprot/Q4R739 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Interacts with PSRC1; recruited by PSRC1 to the spindle during mitosis.|||Phosphorylated during mitosis.|||Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization.|||spindle|||spindle pole http://togogenome.org/gene/9541:RPA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VY20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 3 family.|||Nucleus http://togogenome.org/gene/9541:SERINC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VS73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9541:YAF2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CQ30|||http://purl.uniprot.org/uniprot/I7GL03 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CCNG1 ^@ http://purl.uniprot.org/uniprot/G7P6T9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin G subfamily.|||May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.|||Nucleus http://togogenome.org/gene/9541:EFNA5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7N8|||http://purl.uniprot.org/uniprot/A0A8J8XVD8|||http://purl.uniprot.org/uniprot/G7P813 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:TSEN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.|||Nucleus http://togogenome.org/gene/9541:PPP1R42 ^@ http://purl.uniprot.org/uniprot/Q4R803 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Interacts with PPP1CC isoform gamma-2; the interaction is direct. Interacts with actin, dynein, KIF5B, KIFC1 and tubulin. Associates with microtubules (By similarity).|||Phosphorylated; in the testis.|||Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis.|||centrosome|||cytoskeleton http://togogenome.org/gene/9541:USP35 ^@ http://purl.uniprot.org/uniprot/A0A2K5U812 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9541:MRPS33 ^@ http://purl.uniprot.org/uniprot/A0A8J8YM69|||http://purl.uniprot.org/uniprot/G7P1E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/9541:GPR17 ^@ http://purl.uniprot.org/uniprot/A0A2K5W356 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:ADCY10 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3Y6 ^@ Function|||Similarity ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. Involved in ciliary beat regulation. http://togogenome.org/gene/9541:ZDHHC23 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1H6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:LOC102127617 ^@ http://purl.uniprot.org/uniprot/A0A2K5UY76 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/9541:MRPL19 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ67|||http://purl.uniprot.org/uniprot/G8F3A1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family. http://togogenome.org/gene/9541:TSPYL4 ^@ http://purl.uniprot.org/uniprot/Q9BDD7 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9541:SOX14 ^@ http://purl.uniprot.org/uniprot/G7P040|||http://purl.uniprot.org/uniprot/P61259 ^@ Function|||Subcellular Location Annotation ^@ Acts as a negative regulator of transcription.|||Nucleus http://togogenome.org/gene/9541:PRAF2 ^@ http://purl.uniprot.org/uniprot/G7Q2P6|||http://purl.uniprot.org/uniprot/Q4R4I9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRA1 family.|||Endosome membrane|||Interacts with CCR5 and GDE1.|||May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis (By similarity).|||Membrane http://togogenome.org/gene/9541:USO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJH1|||http://purl.uniprot.org/uniprot/A0A2K5WJK0|||http://purl.uniprot.org/uniprot/A0A2K5WJV7|||http://purl.uniprot.org/uniprot/A0A7N9CYF0|||http://purl.uniprot.org/uniprot/G7P562 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VDP/USO1/EDE1 family.|||Membrane http://togogenome.org/gene/9541:LOC102115890 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPS1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL29 family. http://togogenome.org/gene/9541:CMA1 ^@ http://purl.uniprot.org/uniprot/P56435 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family. Granzyme subfamily.|||Cytoplasmic granule|||Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.|||Secreted http://togogenome.org/gene/9541:LOC102142158 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPZ6 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/9541:NFKB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPZ9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:LOC102121032 ^@ http://purl.uniprot.org/uniprot/G7PRS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SERPINB12 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRK4 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:LOC102119629 ^@ http://purl.uniprot.org/uniprot/G7PS84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CHMP5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XNK1|||http://purl.uniprot.org/uniprot/G7PS50 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9541:TP53RK ^@ http://purl.uniprot.org/uniprot/G7PG31 ^@ Similarity ^@ Belongs to the protein kinase superfamily. BUD32 family. http://togogenome.org/gene/9541:PCSK5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4Q2|||http://purl.uniprot.org/uniprot/A0A2K5X4W2 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9541:CALY ^@ http://purl.uniprot.org/uniprot/A0A2K5WDP1 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/9541:SLC5A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9541:MRPL35 ^@ http://purl.uniprot.org/uniprot/A0A7N9D929|||http://purl.uniprot.org/uniprot/G8F3R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bL35 family.|||Mitochondrion http://togogenome.org/gene/9541:TLCD4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XS27|||http://purl.uniprot.org/uniprot/G7NV14 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:VPS18 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS18 family.|||Membrane http://togogenome.org/gene/9541:IL12B ^@ http://purl.uniprot.org/uniprot/G7P6S2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.|||Belongs to the IL-12B family.|||Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.|||Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer.|||Secreted http://togogenome.org/gene/9541:ACVR2B ^@ http://purl.uniprot.org/uniprot/A0A2K5WUB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9541:AKAP9 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQE0 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/9541:DCST2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VG69 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NOS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3D8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NOS family.|||Binds 1 FAD.|||Binds 1 FMN.|||Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. http://togogenome.org/gene/9541:ATP5PB ^@ http://purl.uniprot.org/uniprot/A0A2K5TRC9|||http://purl.uniprot.org/uniprot/A0A2K5TRE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ATPase B chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/9541:GJB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9541:CFAP418 ^@ http://purl.uniprot.org/uniprot/A0A2K5VME6|||http://purl.uniprot.org/uniprot/G7PC93 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in photoreceptor outer segment disk morphogenesis.|||Photoreceptor inner segment http://togogenome.org/gene/9541:AKAP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTC4|||http://purl.uniprot.org/uniprot/A0A7N9D580 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/9541:ZDHHC14 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVN3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:ETV7 ^@ http://purl.uniprot.org/uniprot/A0A2K5U639 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:TECR ^@ http://purl.uniprot.org/uniprot/I7GD06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:HSD17B7 ^@ http://purl.uniprot.org/uniprot/Q2XQY1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. http://togogenome.org/gene/9541:EYA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQ80|||http://purl.uniprot.org/uniprot/A0A2K5UQA5|||http://purl.uniprot.org/uniprot/A0A8J8Y0Y3|||http://purl.uniprot.org/uniprot/G7PC08 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9541:GCSH ^@ http://purl.uniprot.org/uniprot/A0A8J8YM65|||http://purl.uniprot.org/uniprot/G7PZT7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9541:ANXA11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTK4|||http://purl.uniprot.org/uniprot/G7PEX7|||http://purl.uniprot.org/uniprot/I7GH43 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9541:ORAI3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Orai family.|||Membrane http://togogenome.org/gene/9541:PTGDS ^@ http://purl.uniprot.org/uniprot/Q4R5N0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Membrane|||Monomer.|||Nucleus membrane|||Rough endoplasmic reticulum|||perinuclear region http://togogenome.org/gene/9541:EEF1D ^@ http://purl.uniprot.org/uniprot/A0A2K5WG05|||http://purl.uniprot.org/uniprot/A0A805R9Y0|||http://purl.uniprot.org/uniprot/Q4R3D4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EF-1-beta/EF-1-delta family.|||EF-1 is composed of 4 subunits: alpha, beta, delta isoform 1, and gamma. Isoform 2 interacts with HSF1 and NFE2L2 (By similarity).|||EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.|||Nucleus|||Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). http://togogenome.org/gene/9541:MBOAT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102138082 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCMBP family.|||Nucleus http://togogenome.org/gene/9541:ALKBH5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TU23 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alkB family.|||Monomer.|||Nucleus speckle http://togogenome.org/gene/9541:DENND10 ^@ http://purl.uniprot.org/uniprot/A0A7N9CX28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND10 family.|||Endosome|||Late endosome http://togogenome.org/gene/9541:MRPL22 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTD7|||http://purl.uniprot.org/uniprot/G7P6Q4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9541:CALHM6 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2T0|||http://purl.uniprot.org/uniprot/G7P3L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9541:CLDN12 ^@ http://purl.uniprot.org/uniprot/A0A2K5UH12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Membrane|||tight junction http://togogenome.org/gene/9541:AGPAT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WF11 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/9541:DSC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRM5 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/9541:MGAT5B ^@ http://purl.uniprot.org/uniprot/A0A2K5WKS2|||http://purl.uniprot.org/uniprot/A0A2K5WKT5|||http://purl.uniprot.org/uniprot/A0A2K5WL55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 18 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:LOC102120205 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN65|||http://purl.uniprot.org/uniprot/G7P0Q2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/9541:GABRR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTB5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:KIF12 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5K7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:TMEM175 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM175 family.|||Membrane http://togogenome.org/gene/9541:PDGFRL ^@ http://purl.uniprot.org/uniprot/Q2PFX1 ^@ Subcellular Location Annotation|||Subunit ^@ Forms a complex composed of PDGFRL, TNK2 and GRB2.|||Secreted http://togogenome.org/gene/9541:PIK3CD ^@ http://purl.uniprot.org/uniprot/A0A2K5TKS9|||http://purl.uniprot.org/uniprot/A0A7N9CY41 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9541:USE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X308 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the USE1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:CAST ^@ http://purl.uniprot.org/uniprot/A0A2K5V7W1|||http://purl.uniprot.org/uniprot/A0A2K5V7W9|||http://purl.uniprot.org/uniprot/A0A2K5V7X1|||http://purl.uniprot.org/uniprot/A0A2K5V7Y2|||http://purl.uniprot.org/uniprot/A0A2K5V839 ^@ Function|||Similarity ^@ Belongs to the protease inhibitor I27 (calpastatin) family.|||Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. http://togogenome.org/gene/9541:C1QA ^@ http://purl.uniprot.org/uniprot/A0A2K5WJV6 ^@ Function ^@ C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. http://togogenome.org/gene/9541:PYM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7E5|||http://purl.uniprot.org/uniprot/A0A2K5W7I1|||http://purl.uniprot.org/uniprot/G7PIF7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pym family.|||Cytoplasm|||Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex. http://togogenome.org/gene/9541:CSRNP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8N7|||http://purl.uniprot.org/uniprot/A0A7N9CWX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/9541:ATG5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVV4|||http://purl.uniprot.org/uniprot/A0A2K5WW04|||http://purl.uniprot.org/uniprot/A0A8J8Y5J4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Conjugated with ATG12.|||Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.|||May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.|||Preautophagosomal structure membrane http://togogenome.org/gene/9541:ZNF263 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTS6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FSD1 ^@ http://purl.uniprot.org/uniprot/Q4R539 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ B30.2 box contains a microtubule-binding site.|||Cleavage furrow|||Cytoplasm|||May be involved in microtubule organization and stabilization.|||Nucleus|||Oligomerization is required for binding to microtubules.|||centrosome http://togogenome.org/gene/9541:MC1R ^@ http://purl.uniprot.org/uniprot/A3KF54|||http://purl.uniprot.org/uniprot/A3KF60 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with OPN3; the interaction results in a decrease in MC1R-mediated cAMP signaling and ultimately a decrease in melanin production in melanocytes.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. http://togogenome.org/gene/9541:ZSCAN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUD4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SEPTIN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WM76|||http://purl.uniprot.org/uniprot/A0A2K5WMG6|||http://purl.uniprot.org/uniprot/A0A2K5WN04|||http://purl.uniprot.org/uniprot/I7GNK1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9541:TAFA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UI35|||http://purl.uniprot.org/uniprot/A0A7N9D012|||http://purl.uniprot.org/uniprot/Q9N0D3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAFA family.|||Modulates injury-induced and chemical pain hypersensitivity. Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release.|||Secreted http://togogenome.org/gene/9541:LOC102136630 ^@ http://purl.uniprot.org/uniprot/A0A2K5VI12|||http://purl.uniprot.org/uniprot/A0A2K5VI22|||http://purl.uniprot.org/uniprot/A0A2K5VI59|||http://purl.uniprot.org/uniprot/A0A2K5VI65|||http://purl.uniprot.org/uniprot/A0A2K5VI79|||http://purl.uniprot.org/uniprot/A0A2K5VI87 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/9541:MRPL50 ^@ http://purl.uniprot.org/uniprot/A0A7N9D744 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL50 family.|||Mitochondrion http://togogenome.org/gene/9541:ITPKA ^@ http://purl.uniprot.org/uniprot/A0A2K5WY52 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9541:EPHA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPT2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ASF1A ^@ http://purl.uniprot.org/uniprot/A0A2K5VAE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/9541:MAB21L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TP07 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9541:TRPC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8G6|||http://purl.uniprot.org/uniprot/A0A2K5X8K7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:UPK1B ^@ http://purl.uniprot.org/uniprot/A0A8J8YPH5|||http://purl.uniprot.org/uniprot/G7NXN2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tetraspanin (TM4SF) family.|||Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).|||Membrane http://togogenome.org/gene/9541:GCFC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ98 ^@ Similarity ^@ Belongs to the GCF family. http://togogenome.org/gene/9541:CLIC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCD5|||http://purl.uniprot.org/uniprot/A0A2K5UCE6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9541:FGF8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBN1|||http://purl.uniprot.org/uniprot/A0A2K5WBU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Secreted http://togogenome.org/gene/9541:PXMP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TV73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/9541:LOC102123567 ^@ http://purl.uniprot.org/uniprot/A0A2K5V040|||http://purl.uniprot.org/uniprot/A0A2K5V0A2 ^@ Similarity ^@ Belongs to the LEO1 family. http://togogenome.org/gene/9541:ATP1A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102131730 ^@ http://purl.uniprot.org/uniprot/A0A2K5V997 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:ZNF18 ^@ http://purl.uniprot.org/uniprot/A0A2K5VB21 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SSR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4H4|||http://purl.uniprot.org/uniprot/Q4R4P7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-alpha family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.|||Membrane|||Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. http://togogenome.org/gene/9541:HDAC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGF8|||http://purl.uniprot.org/uniprot/A0A2K5VGP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. http://togogenome.org/gene/9541:ENO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXB8|||http://purl.uniprot.org/uniprot/Q4R5L2 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the enolase family.|||Binds two Mg(2+) per subunit. Required for catalysis and for stabilizing the dimer.|||Cell membrane|||Cytoplasm|||Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.|||ISGylated.|||Lysine 2-hydroxyisobutyrylation (Khib) by p300/EP300 activates the phosphopyruvate hydratase activity.|||Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific. ENO1 interacts with PLG in the neuronal plasma membrane and promotes its activation. The C-terminal lysine is required for this binding. Interacts with ENO4 and PGAM2 (By similarity). Interacts with CMTM6 (By similarity). http://togogenome.org/gene/9541:VILL ^@ http://purl.uniprot.org/uniprot/A0A2K5TXC1 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/9541:FOXP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X941 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NTRK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VS06|||http://purl.uniprot.org/uniprot/A0A2K5VS28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ELMO3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQB0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/9541:S1PR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHU7|||http://purl.uniprot.org/uniprot/A0A7N9I9K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102127523 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SOAT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V656 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:ROPN1L ^@ http://purl.uniprot.org/uniprot/Q4R760 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ropporin family.|||Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.|||May interact with AKAP3 (By similarity). Interacts with FSCB; the interaction increases upon spermatozoa capacitation conditions (By similarity).|||Sumoylated, sumoylation decreases upon spermatozoa capacitation conditions.|||cilium|||flagellum http://togogenome.org/gene/9541:ADK ^@ http://purl.uniprot.org/uniprot/A0A2K5VIG9|||http://purl.uniprot.org/uniprot/A0A2K5VIH5|||http://purl.uniprot.org/uniprot/A0A2K5VIJ9|||http://purl.uniprot.org/uniprot/A0A7N9D543|||http://purl.uniprot.org/uniprot/A0A7N9D865 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.|||Belongs to the carbohydrate kinase PfkB family.|||Binds 3 Mg(2+) ions per subunit.|||Monomer.|||Nucleus http://togogenome.org/gene/9541:CDCA7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TND4|||http://purl.uniprot.org/uniprot/A0A2K5TND6|||http://purl.uniprot.org/uniprot/A0A8J8XQ54 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:USP7 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1Z9|||http://purl.uniprot.org/uniprot/A0A2K5X2D8|||http://purl.uniprot.org/uniprot/A0A2K5X2E2 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9541:LIN7A ^@ http://purl.uniprot.org/uniprot/A0A2K5X044 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/9541:RIMKLA ^@ http://purl.uniprot.org/uniprot/A0A2K5VKU1 ^@ Similarity ^@ Belongs to the RimK family. http://togogenome.org/gene/9541:ZNF322 ^@ http://purl.uniprot.org/uniprot/Q4R7X8 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||Cytoplasm|||Interacts with POU5F1.|||Nucleus|||Significantly enhances POU5F1/OCT4-SOX2-KLF4-MYC (OSKM) mediated reprogramming of mouse embryonic fibroblasts into induced pluripotent stem cells, and can also substitute for SOX2 in this process.|||Transcriptional activator. Important for maintenance of pluripotency in embryonic stem cells. Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes. Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly. Promotes inhibition of MAPK signaling during embryonic stem cell differentiation. http://togogenome.org/gene/9541:PITPNM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WS36 ^@ Similarity ^@ Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. http://togogenome.org/gene/9541:DDB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZB4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDB1 family.|||Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock.|||Component of the UV-DDB complex.|||Nucleus|||The core of the protein consists of three WD40 beta-propeller domains. http://togogenome.org/gene/9541:LOC102131735 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR24 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102122191 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/9541:DRAXIN ^@ http://purl.uniprot.org/uniprot/A0A2K5X1K8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the draxin family.|||Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.|||Interacts with LRP6.|||Secreted http://togogenome.org/gene/9541:RBL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the retinoblastoma protein (RB) family.|||Nucleus http://togogenome.org/gene/9541:CLN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0H7|||http://purl.uniprot.org/uniprot/A0A2K5X0Y0|||http://purl.uniprot.org/uniprot/I7G3Q7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the battenin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9541:SLC33A1 ^@ http://purl.uniprot.org/uniprot/I7GL61 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:HNRNPD ^@ http://purl.uniprot.org/uniprot/A0A2K5UXA3|||http://purl.uniprot.org/uniprot/A0A2K5UXA5|||http://purl.uniprot.org/uniprot/A0A2K5UXI0|||http://purl.uniprot.org/uniprot/A0A7N9DEU8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:AASS ^@ http://purl.uniprot.org/uniprot/A0A2K5WM48 ^@ Similarity ^@ In the C-terminal section; belongs to the saccharopine dehydrogenase family.|||In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/9541:SLC35B1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4I0|||http://purl.uniprot.org/uniprot/G7PU92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9541:CDK6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XB64|||http://purl.uniprot.org/uniprot/G7P1D7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:RPL22L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVQ1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/9541:PADI1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YFJ7|||http://purl.uniprot.org/uniprot/G7NUR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9541:STN1 ^@ http://purl.uniprot.org/uniprot/G7PDW8|||http://purl.uniprot.org/uniprot/Q4R804 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the STN1 family.|||Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.|||Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Required for efficicient replication of the duplex region of the telomere. Promotes efficient replication of lagging-strand telomeres. Promotes general replication start following replication-fork stalling implicating new origin firing. May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication (By similarity).|||Component of the CST complex, composed of TEN1/C17orf106, CTC1/C17orf68 and STN1; in the complex interacts directly with TEN1 and CTC1. Interacts with ACD/TPP1, POT1 and POLA1.|||Component of the CST complex.|||Nucleus|||telomere http://togogenome.org/gene/9541:MAPK1IP1L ^@ http://purl.uniprot.org/uniprot/Q4R837 ^@ Similarity ^@ Belongs to the MISS family. http://togogenome.org/gene/9541:TRAPPC5 ^@ http://purl.uniprot.org/uniprot/I7GAW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/9541:TNC ^@ http://purl.uniprot.org/uniprot/A0A2K5TX89|||http://purl.uniprot.org/uniprot/A0A2K5TXA7|||http://purl.uniprot.org/uniprot/A0A2K5TXC7|||http://purl.uniprot.org/uniprot/A0A2K5TXD6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:PLPPR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHK0|||http://purl.uniprot.org/uniprot/G7PZE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9541:CLP1 ^@ http://purl.uniprot.org/uniprot/G7PQ31|||http://purl.uniprot.org/uniprot/Q4R7R3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Clp1 family. Clp1 subfamily.|||Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.|||Nucleus|||Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.|||Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing (By similarity). http://togogenome.org/gene/9541:POMGNT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 61 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:KCNV2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVN7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:PDE1A ^@ http://purl.uniprot.org/uniprot/A0A2K5WGG4|||http://purl.uniprot.org/uniprot/A0A2K5WGH9|||http://purl.uniprot.org/uniprot/A0A2K5WGI0|||http://purl.uniprot.org/uniprot/A0A2K5WGQ6|||http://purl.uniprot.org/uniprot/A0A7N9CCQ5 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:DUSP13 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMJ2|||http://purl.uniprot.org/uniprot/A0A2K5UMJ6|||http://purl.uniprot.org/uniprot/A0A2K5UMN5|||http://purl.uniprot.org/uniprot/A0A7N9C7Z2 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9541:CORO7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat coronin family.|||Cytoplasmic vesicle|||F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.|||Golgi apparatus membrane|||Membrane|||Vesicle|||cytosol|||trans-Golgi network http://togogenome.org/gene/9541:CENPT ^@ http://purl.uniprot.org/uniprot/G7Q1E8|||http://purl.uniprot.org/uniprot/Q4R5U8 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CENP-T/CNN1 family.|||Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Identified in a centromeric complex containing histones H2A, H2B, H3 and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1. Interacts (via N-terminus) with the NDC80 complex. Heterodimer with CENPW; this dimer coassembles with CENPS-CENPX heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex.|||Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.|||Dynamically phosphorylated during the cell cycle. Phosphorylated during G2 phase, metaphase and anaphase, but not during telophase or G1 phase.|||Nucleus|||The largest part of the sequence forms an elongated and flexible stalk structure that is connected to a C-terminal globular domain with a histone-type fold.|||centromere|||kinetochore http://togogenome.org/gene/9541:SLC5A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ85|||http://purl.uniprot.org/uniprot/A0A2K5TZ86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9541:MED24 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2W8|||http://purl.uniprot.org/uniprot/A0A2K5W2X0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 24 family.|||Nucleus http://togogenome.org/gene/9541:ABRAXAS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6M9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM175 family. Abraxas subfamily.|||Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.|||Nucleus http://togogenome.org/gene/9541:IL25 ^@ http://purl.uniprot.org/uniprot/A0A2K5TY65|||http://purl.uniprot.org/uniprot/G7P9V9 ^@ Similarity ^@ Belongs to the IL-17 family. http://togogenome.org/gene/9541:SIRT6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TU92 ^@ Activity Regulation|||Disruption Phenotype|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated at Lys-33. Deacetylation at Lys-33 by SIRT1 promotes homomultimerization and binding to double-strand breaks (DSBs) sites.|||Belongs to the sirtuin family. Class IV subfamily.|||Chromosome|||Compared to the defatty-acylase activity, the protein deacetylase activity is weak in vitro, and requires activation. The histone deacetylase activity is strongly activated upon binding to nucleosomes and chromatin in vivo. Two molecules of SIRT6 associate with the acidic patch of one nucleosome, while the C-terminal disordered region of SIRT6 associates with nucleosomal DNA, leading to efficient histone deacetylation. The protein-lysine deacetylase activity is also activated by long-chain free fatty-acids.|||Endoplasmic reticulum|||Homodimer; binds to nucleosomes and DNA ends as a homodimer (By similarity). Interacts with RELA; interferes with RELA binding to target DNA (By similarity). Interacts with SMARCA5; promoting recruitment of SMARCA5/SNF2H to double-strand breaks (DSBs) sites (By similarity). Interacts with the mTORC2 complex; preventing the ability of SIRT6 to deacetylate FOXO1. Interacts with the CLOCK-BMAL1 complex; recruited by the CLOCK-BMAL1 complex to regulate expression of clock-controlled genes. Interacts with CSNK2A2; preventing CSNK2A2 localization to the nucleus (By similarity).|||Monkeys die soon after birth and exhibit severe prenatal developmental retardation (PubMed:30135584). The molecular developmental stage of the monkeys mimics that of wild-type fetuses at 2-4 months of gestational age (PubMed:30135584). Neuronal differentiation is strongly delayed, due to hyperacetylation of histone H3 at 'Lys-56' (H3K56ac), leading to up-regulation of the long non-coding RNA H19 (PubMed:30135584).|||Monoubiquitinated at Lys-170 by STUB1/CHIP, preventing its degradation by the proteasome.|||NAD-dependent protein deacetylase, deacylase and mono-ADP-ribosyltransferase that plays an essential role in DNA damage repair, telomere maintenance, metabolic homeostasis, inflammation, tumorigenesis and aging (PubMed:30135584). Displays protein-lysine deacetylase or defatty-acylase (demyristoylase and depalmitoylase) activity, depending on the context (By similarity). Acts as a key histone deacetylase by catalyzing deacetylation of histone H3 at 'Lys-9', 'Lys-18' and 'Lys-56' (H3K9ac, H3K18ac and H3K56ac, respectively), suppressing target gene expression of several transcription factors, including NF-kappa-B (PubMed:30135584). Acts as an inhibitor of transcription elongation by mediating deacetylation of H3K9ac and H3K56ac, preventing release of NELFE from chromatin and causing transcriptional pausing (By similarity). Involved in DNA repair by promoting double-strand break (DSB) repair: acts as a DSB sensor by recognizing and binding DSB sites, leading to (1) recruitment of DNA repair proteins, such as SMARCA5/SNF2H, and (2) deacetylation of histone H3K9ac and H3K56ac (By similarity). SIRT6 participation to DSB repair is probably involved in extension of life span (By similarity). Also promotes DNA repair by deacetylating non-histone proteins, such as DDB2 and p53/TP53 (By similarity). Specifically deacetylates H3K18ac at pericentric heterochromatin, thereby maintaining pericentric heterochromatin silencing at centromeres and protecting against genomic instability and cellular senescence (By similarity). Involved in telomere maintenance by catalyzing deacetylation of histone H3 in telomeric chromatin, regulating telomere position effect and telomere movement in response to DNA damage (By similarity). Required for embryonic stem cell differentiation by mediating histone deacetylation of H3K9ac (By similarity). Plays a major role in metabolism by regulating processes such as glycolysis, gluconeogenesis, insulin secretion and lipid metabolism (By similarity). Inhibits glycolysis via histone deacetylase activity and by acting as a corepressor of the transcription factor HIF1A, thereby controlling the expression of multiple glycolytic genes (By similarity). Has tumor suppressor activity by repressing glycolysis, thereby inhibiting the Warburg effect (By similarity). Also regulates glycolysis and tumorigenesis by mediating deacetylation and nuclear export of non-histone proteins, such as isoform M2 of PKM (PKM2) (By similarity). Acts as a negative regulator of gluconeogenesis by mediating deacetylation of non-histone proteins, such as FOXO1 and KAT2A/GCN5 (By similarity). Promotes beta-oxidation of fatty acids during fasting by catalyzing deacetylation of NCOA2, inducing coactivation of PPARA (By similarity). Acts as a regulator of lipid catabolism in brown adipocytes, both by catalyzing deacetylation of histones and non-histone proteins, such as FOXO1 (By similarity). Also acts as a regulator of circadian rhythms, both by regulating expression of clock-controlled genes involved in lipid and carbohydrate metabolism, and by catalyzing deacetylation of PER2 (By similarity). The defatty-acylase activity is specifically involved in regulation of protein secretion (By similarity). Has high activity toward long-chain fatty acyl groups and mediates protein-lysine demyristoylation and depalmitoylation of target proteins, such as RRAS2 and TNF, thereby regulating their secretion (By similarity). Also acts as a mono-ADP-ribosyltransferase by mediating mono-ADP-ribosylation of PARP1, TRIM28/KAP1 or SMARCC2/BAF170 (By similarity). Mono-ADP-ribosyltransferase activity is involved in DNA repair, cellular senescence, repression of LINE-1 retrotransposon elements and regulation of transcription (By similarity).|||Nucleus|||Phosphorylation at Ser-10 by MAPK8/JNK1 in response to oxidative stress stimulates the mono-ADP-ribosyltransferase activity on PARP1, leading to PARP1 recruitment to double-strand breaks (DSBs).|||Sumoylated, leading to specifically decrease ability to deacetylate histone H3 at 'Lys-56' (H3K56ac).|||The C-terminal disordered region mediates non-specific DNA-binding.|||telomere http://togogenome.org/gene/9541:TRIM25 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDN3|||http://purl.uniprot.org/uniprot/G7PUD8 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/9541:LOC102123447 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBM3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer or homodimer. http://togogenome.org/gene/9541:TTC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVM5 ^@ Similarity ^@ Belongs to the TTC4 family. http://togogenome.org/gene/9541:GJB4 ^@ http://purl.uniprot.org/uniprot/G7NTG2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9541:CREM ^@ http://purl.uniprot.org/uniprot/A0A2K5VK43|||http://purl.uniprot.org/uniprot/A0A2K5VKH5|||http://purl.uniprot.org/uniprot/A0A2K5VKH8|||http://purl.uniprot.org/uniprot/A0A2K5VKI3|||http://purl.uniprot.org/uniprot/A0A2K5VKI5|||http://purl.uniprot.org/uniprot/A0A2K5VKL3|||http://purl.uniprot.org/uniprot/A0A7N9DAB8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ESAM ^@ http://purl.uniprot.org/uniprot/Q95KI3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Can mediate aggregation most likely through a homophilic molecular interaction.|||Cell membrane|||Interacts with MAGI1.|||adherens junction|||tight junction http://togogenome.org/gene/9541:VPS29 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0S8|||http://purl.uniprot.org/uniprot/A0A2K5U0U4|||http://purl.uniprot.org/uniprot/A0A2K5U0Y9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.|||Belongs to the VPS29 family.|||Endosome membrane http://togogenome.org/gene/9541:MAK16 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUL8 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/9541:COL4A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U207 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9541:CCNT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0G8 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin C subfamily. http://togogenome.org/gene/9541:ATP5F1B ^@ http://purl.uniprot.org/uniprot/A0A2K5WEF7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/9541:MINDY3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CXL7|||http://purl.uniprot.org/uniprot/G7PEF7|||http://purl.uniprot.org/uniprot/Q4R528 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.|||Interacts with COPS5.|||Nucleus http://togogenome.org/gene/9541:MAN2C1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U911 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 38 family. http://togogenome.org/gene/9541:GINS4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XEM9|||http://purl.uniprot.org/uniprot/G7PD92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Chromosome|||Nucleus|||Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/9541:ADGRA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5USY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/9541:LOC102129434 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDR6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/9541:NDUFA10 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTY4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA10 subunit family.|||Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.|||Mitochondrion matrix http://togogenome.org/gene/9541:NKX6-2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUM2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ERBB3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XF73|||http://purl.uniprot.org/uniprot/G7PIG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9541:MOG ^@ http://purl.uniprot.org/uniprot/Q29ZP0|||http://purl.uniprot.org/uniprot/Q29ZP1|||http://purl.uniprot.org/uniprot/Q29ZP6|||http://purl.uniprot.org/uniprot/Q29ZP7|||http://purl.uniprot.org/uniprot/Q9BGS7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).|||Homodimer.|||Membrane|||Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion (By similarity).|||Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. http://togogenome.org/gene/9541:CFHR5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEG5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:HOXA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9541:TRNT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRQ5|||http://purl.uniprot.org/uniprot/G7NYX0 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/9541:DCTD ^@ http://purl.uniprot.org/uniprot/A0A2K5WHP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Cytoplasm http://togogenome.org/gene/9541:ASAH1 ^@ http://purl.uniprot.org/uniprot/I7GEN4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acid ceramidase family.|||Heterodimer.|||Lysosome http://togogenome.org/gene/9541:PEX7 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat peroxin-7 family.|||Cytoplasm http://togogenome.org/gene/9541:PTGR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQJ4|||http://purl.uniprot.org/uniprot/A0A7N9DCK9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9541:PLIN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXC7 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9541:SPOCK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZ19 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:RBPJ ^@ http://purl.uniprot.org/uniprot/A0A2K5TVV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Su(H) family.|||Nucleus http://togogenome.org/gene/9541:PALS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJF0|||http://purl.uniprot.org/uniprot/A0A2K5UJH6|||http://purl.uniprot.org/uniprot/Q4R7B5|||http://purl.uniprot.org/uniprot/Q4R814 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9541:STMN3 ^@ http://purl.uniprot.org/uniprot/Q4R4N5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the stathmin family.|||Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.|||Golgi apparatus|||Interacts with STAT3. Interacts with CLU (secreted form); this interaction may act as an important modulator during neuronal differentiation (By similarity).|||N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15 (By similarity).|||axon|||cytosol|||growth cone http://togogenome.org/gene/9541:ATP5MC3 ^@ http://purl.uniprot.org/uniprot/G7PKV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9541:AGBL2 ^@ http://purl.uniprot.org/uniprot/Q4R632 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M14 family.|||Binds 1 zinc ion per subunit.|||Inhibited by RARRES1.|||Interacts with RARRES1, KIF11 and MAPRE1.|||Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK.|||Was initially shown to catalyze the removal of carboxy-terminus tyrosine from alpha-tubulin (By similarity). However, later studies did not identified any detyrosinase or deglycylase activities from the carboxy-terminus of tubulin (By similarity).|||Was originally thought to have detyrosinating activity from C-terminal positions on tubulin.|||centriole|||cilium basal body|||cytosol http://togogenome.org/gene/9541:GLYCTK ^@ http://purl.uniprot.org/uniprot/A0A2K5V6G9 ^@ Similarity ^@ Belongs to the glycerate kinase type-2 family. http://togogenome.org/gene/9541:MAP2K5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQ60|||http://purl.uniprot.org/uniprot/Q2PFR6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:CYP2C76 ^@ http://purl.uniprot.org/uniprot/Q0HA17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:PFN2 ^@ http://purl.uniprot.org/uniprot/Q4R4P8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the profilin family.|||Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).|||Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio (By similarity). Interacts with PFN2 (By similarity).|||cytoskeleton http://togogenome.org/gene/9541:NDUFAF3 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y929|||http://purl.uniprot.org/uniprot/G7NXV0 ^@ Function|||Subcellular Location Annotation ^@ Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Membrane|||Mitochondrion inner membrane|||Nucleus http://togogenome.org/gene/9541:STAG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHU2|||http://purl.uniprot.org/uniprot/A0A8J8XEF3|||http://purl.uniprot.org/uniprot/G7NXX5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/9541:PIK3C2B ^@ http://purl.uniprot.org/uniprot/A0A2K5W9G8 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9541:RDH8 ^@ http://purl.uniprot.org/uniprot/A0A8J8YHB7|||http://purl.uniprot.org/uniprot/G7PZ59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Membrane|||Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity. http://togogenome.org/gene/9541:HIGD1A ^@ http://purl.uniprot.org/uniprot/A0A8J8YGQ2|||http://purl.uniprot.org/uniprot/G7NY64 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9541:NPL ^@ http://purl.uniprot.org/uniprot/A0A2K5WFI8|||http://purl.uniprot.org/uniprot/A0A8J8XEN5|||http://purl.uniprot.org/uniprot/G7NXG9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family. NanA subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/9541:CFAP45 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWS4|||http://purl.uniprot.org/uniprot/Q4R8K2 ^@ Similarity ^@ Belongs to the CFAP45 family. http://togogenome.org/gene/9541:SLC2A12 ^@ http://purl.uniprot.org/uniprot/Q9BE72 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Endomembrane system|||Insulin-independent facilitative glucose transporter.|||perinuclear region http://togogenome.org/gene/9541:LOC102130508 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0N3|||http://purl.uniprot.org/uniprot/G7PP72 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.|||May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. http://togogenome.org/gene/9541:GHRL ^@ http://purl.uniprot.org/uniprot/A0A2K5VHC7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the motilin family.|||Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.|||O-octanoylation is essential for ghrelin activity.|||Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.|||Secreted http://togogenome.org/gene/9541:TMEM233 ^@ http://purl.uniprot.org/uniprot/A0A7N9D303 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:PDE4B ^@ http://purl.uniprot.org/uniprot/A0A2K5U5W0|||http://purl.uniprot.org/uniprot/A0A2K5U5Z5|||http://purl.uniprot.org/uniprot/A0A8J8YHZ4|||http://purl.uniprot.org/uniprot/G7NW27 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:PACSIN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWB5|||http://purl.uniprot.org/uniprot/A0A2K5WWJ9|||http://purl.uniprot.org/uniprot/G7PFV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PACSIN family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome|||Endosome membrane|||Membrane|||Recycling endosome membrane|||caveola|||cytoskeleton|||ruffle membrane http://togogenome.org/gene/9541:SLC26A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Cell membrane|||Membrane|||Sodium-independent transporter of chloride and iodide. http://togogenome.org/gene/9541:LOC102138926 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPU0 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/9541:CCL25 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSD9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:SLC24A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9541:SH2B3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CRG6 ^@ Similarity ^@ Belongs to the SH2B adapter family. http://togogenome.org/gene/9541:MAGEB18 ^@ http://purl.uniprot.org/uniprot/Q4R998 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with LNX1.|||May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity). http://togogenome.org/gene/9541:MANEA ^@ http://purl.uniprot.org/uniprot/A0A8J8YEI5|||http://purl.uniprot.org/uniprot/G7P424 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:LOC102138874 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNE4 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9541:CYP2C18 ^@ http://purl.uniprot.org/uniprot/A0A2K5UX32|||http://purl.uniprot.org/uniprot/E0V8I6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:LMNA ^@ http://purl.uniprot.org/uniprot/A0A8J8YBF0|||http://purl.uniprot.org/uniprot/G7NV78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||Nucleus lamina http://togogenome.org/gene/9541:PSMC4 ^@ http://purl.uniprot.org/uniprot/G7PXK9|||http://purl.uniprot.org/uniprot/Q4R7L3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AAA ATPase family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC4 and few additional components. Interacts with NR1I3. Interacts with PAAF1. Interacts with TRIM5. Interacts with ZFAND1 (By similarity).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:B3GALT4 ^@ http://purl.uniprot.org/uniprot/I7GK51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:PIAS1 ^@ http://purl.uniprot.org/uniprot/Q4R996 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/9541:CAVIN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola|||sarcomere http://togogenome.org/gene/9541:RET ^@ http://purl.uniprot.org/uniprot/A0A2K5V8L5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane|||Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. http://togogenome.org/gene/9541:LARP7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMC6|||http://purl.uniprot.org/uniprot/Q4R627 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LARP7 family.|||Core component of the 7SK RNP complex, at least composed of 7SK RNA, LARP7, MEPCE, HEXIM1 (or HEXIM2) and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1). Interacts with METTL16. Interacts with RBM7; upon genotoxic stress this interaction is enhanced, triggering the release of inactive P-TEFb complex from the core, yielding to P-TEFb complex activation. Associates with box C/D small nucleolar ribonucleoprotein (snoRNP) complexes.|||RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function. Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II. The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex. LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing. Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes. U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity. Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (By similarity). U6 snRNA processing is required for spermatogenesis (By similarity).|||The xRRM domain binds the 3' end of 7SK snRNA (7SK RNA) at the top of stem-loop 4.|||nucleoplasm http://togogenome.org/gene/9541:DNAJC2 ^@ http://purl.uniprot.org/uniprot/G7P1Y7|||http://purl.uniprot.org/uniprot/Q4R8H2 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.|||Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2 (By similarity). Interacts (via ZRF1-UBD region) with ID1 (By similarity).|||Nucleus|||Phosphorylated in M (mitotic) phase.|||The ZRF1-UBD region specifically recognizes and binds H2AK119ub. The ZRF1-UBD region is also involved in protein-protein interactions with other proteins, suggesting that it may be masked by some regulator, thereby preventing its association with H2AK119ub.|||cytosol http://togogenome.org/gene/9541:EXOC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2F7 ^@ Function|||Similarity ^@ Belongs to the SEC8 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9541:LOC102114846 ^@ http://purl.uniprot.org/uniprot/A0A023JCA5 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9541:SLC38A11 ^@ http://purl.uniprot.org/uniprot/Q8HXI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid/polyamine transporter 2 family.|||Membrane|||Putative sodium-dependent amino acid/proton antiporter. http://togogenome.org/gene/9541:LOC102124081 ^@ http://purl.uniprot.org/uniprot/A0A2K5UF96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SRFBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUL1|||http://purl.uniprot.org/uniprot/A0A2K5UUQ8 ^@ Function|||Subunit ^@ Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.|||May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells. http://togogenome.org/gene/9541:CGAS ^@ http://purl.uniprot.org/uniprot/A0A2K5WT00 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9541:RIOX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVK1|||http://purl.uniprot.org/uniprot/G7NZ70 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ROX family. MINA53 subfamily.|||Binds 1 Fe(2+) ion per subunit.|||Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.|||nucleolus http://togogenome.org/gene/9541:WRNIP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7J6 ^@ Similarity ^@ Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. http://togogenome.org/gene/9541:CLCC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel MCLC family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/9541:NMT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEF7 ^@ Function|||Similarity ^@ Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.|||Belongs to the NMT family. http://togogenome.org/gene/9541:FAM200A ^@ http://purl.uniprot.org/uniprot/Q4R6P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM200 family.|||Membrane http://togogenome.org/gene/9541:LOC102138266 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZK6 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9541:TSSK2 ^@ http://purl.uniprot.org/uniprot/Q4R8P4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:FZD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLJ1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PDE5A ^@ http://purl.uniprot.org/uniprot/A0A2K5U205|||http://purl.uniprot.org/uniprot/A0A2K5U243|||http://purl.uniprot.org/uniprot/A0A8J8Y3N4 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:LOC102130817 ^@ http://purl.uniprot.org/uniprot/A0A0H3UJW9 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9541:GH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/9541:CD200R1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLV7|||http://purl.uniprot.org/uniprot/A0A2K5WLW2|||http://purl.uniprot.org/uniprot/G7NZT0 ^@ Similarity ^@ Belongs to the CD200R family. http://togogenome.org/gene/9541:TFEC ^@ http://purl.uniprot.org/uniprot/A0A2K5V9X1|||http://purl.uniprot.org/uniprot/A0A2K5VA00|||http://purl.uniprot.org/uniprot/A0A7N9CGQ0|||http://purl.uniprot.org/uniprot/G7P2I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9541:DEFB128 ^@ http://purl.uniprot.org/uniprot/A4H255 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:EIF2B5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUN2 ^@ Similarity ^@ Belongs to the eIF-2B gamma/epsilon subunits family. http://togogenome.org/gene/9541:LY6G5C ^@ http://purl.uniprot.org/uniprot/A0A7N9CQK9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Forms oligomers.|||May have a role in hematopoietic cell differentiation.|||Secreted http://togogenome.org/gene/9541:MARCO ^@ http://purl.uniprot.org/uniprot/A0A2K5X0Z2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:CERT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5URZ1|||http://purl.uniprot.org/uniprot/A0A2K5US20|||http://purl.uniprot.org/uniprot/A0A7N9CN24|||http://purl.uniprot.org/uniprot/A0A8J8Y6D8|||http://purl.uniprot.org/uniprot/G7P7R6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Golgi apparatus http://togogenome.org/gene/9541:ELF1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YI97|||http://purl.uniprot.org/uniprot/G7PW33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:LIPA ^@ http://purl.uniprot.org/uniprot/A0A2K5VBG9|||http://purl.uniprot.org/uniprot/Q4R4S5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol.|||Glycosylation is not essential for catalytic activity.|||Lysosome|||Monomer. http://togogenome.org/gene/9541:SLC25A17 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:LOC102134405 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2M0 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:BRPF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVC2|||http://purl.uniprot.org/uniprot/A0A8J8XYP3|||http://purl.uniprot.org/uniprot/G7NYU9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:STXBP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXA1|||http://purl.uniprot.org/uniprot/A0A2K5TXA4|||http://purl.uniprot.org/uniprot/A0A2K5TXC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:BLCAP ^@ http://purl.uniprot.org/uniprot/A0A7N9CIA7|||http://purl.uniprot.org/uniprot/A0A8J8Y731 ^@ Function|||Similarity ^@ Belongs to the BLCAP family.|||May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B. http://togogenome.org/gene/9541:SNX8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/9541:LOC102118628 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5T0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:MPO ^@ http://purl.uniprot.org/uniprot/A0A2K5UPZ9 ^@ Cofactor ^@ Binds 1 Ca(2+) ion per monomer.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per monomer. http://togogenome.org/gene/9541:TMEM45A ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5X3|||http://purl.uniprot.org/uniprot/G7NZP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9541:TM6SF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UD60 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:RPRD1A ^@ http://purl.uniprot.org/uniprot/A0A2K5TPT9 ^@ Function|||Similarity|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. http://togogenome.org/gene/9541:GPC6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNV2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan that bears heparan sulfate. http://togogenome.org/gene/9541:TNFSF13B ^@ http://purl.uniprot.org/uniprot/A0A2K5V2X4 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9541:CPT2 ^@ http://purl.uniprot.org/uniprot/Q60HG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:MARK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X332|||http://purl.uniprot.org/uniprot/A0A2K5X343|||http://purl.uniprot.org/uniprot/A0A2K5X387 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9541:RRP12 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXV4|||http://purl.uniprot.org/uniprot/G7PDN9 ^@ Similarity ^@ Belongs to the RRP12 family. http://togogenome.org/gene/9541:KIF15 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||spindle http://togogenome.org/gene/9541:LOC102121807 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CLEC12A ^@ http://purl.uniprot.org/uniprot/A0A2K5WXQ6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:PLEKHA8 ^@ http://purl.uniprot.org/uniprot/G7P0H6 ^@ Subcellular Location Annotation ^@ Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:STX6 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Golgi apparatus membrane http://togogenome.org/gene/9541:DGAT2L6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0C2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:MSMB ^@ http://purl.uniprot.org/uniprot/A0A2K5WFL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/9541:SEPSECS ^@ http://purl.uniprot.org/uniprot/A0A2K5WAA0|||http://purl.uniprot.org/uniprot/G7P5C5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SepSecS family.|||Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.|||Cytoplasm|||Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer. http://togogenome.org/gene/9541:GPBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TL91|||http://purl.uniprot.org/uniprot/A0A8J8YGF1|||http://purl.uniprot.org/uniprot/G7P7J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/9541:TMEM39B ^@ http://purl.uniprot.org/uniprot/A0A2K5TPN6|||http://purl.uniprot.org/uniprot/A0A2K5TPQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/9541:KLHL36 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUK0 ^@ Function ^@ Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9541:ZNF500 ^@ http://purl.uniprot.org/uniprot/A0A2K5V409 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SLA ^@ http://purl.uniprot.org/uniprot/A0A2K5W9Z8|||http://purl.uniprot.org/uniprot/I7G5L0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:CTNS ^@ http://purl.uniprot.org/uniprot/A0A2K5U1W1|||http://purl.uniprot.org/uniprot/A0A2K5U1Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystinosin family.|||Membrane http://togogenome.org/gene/9541:TBX10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDB5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:UNC5CL ^@ http://purl.uniprot.org/uniprot/A0A2K5V3E7 ^@ Similarity ^@ Belongs to the unc-5 family. http://togogenome.org/gene/9541:ARRDC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WC33|||http://purl.uniprot.org/uniprot/A0A2K5WC63 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9541:DMGDH ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ46 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/9541:ITGA9 ^@ http://purl.uniprot.org/uniprot/A0A2K5U396 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9541:MEF2A ^@ http://purl.uniprot.org/uniprot/A0A2K5VXR6|||http://purl.uniprot.org/uniprot/A0A2K5VXV0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ALG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W716 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.|||Membrane http://togogenome.org/gene/9541:GTPBP10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHT5 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/9541:FUNDC2 ^@ http://purl.uniprot.org/uniprot/I7GEG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9541:MLN ^@ http://purl.uniprot.org/uniprot/A0A2K5V0J0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the motilin family.|||Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.|||Secreted http://togogenome.org/gene/9541:LOC102117500 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNM3 ^@ Similarity ^@ Belongs to the HPF1 family. http://togogenome.org/gene/9541:LY75 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1W8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:NANOG ^@ http://purl.uniprot.org/uniprot/Q5TM84 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nanog homeobox family.|||Expressed in embryonic stem (ES) cells.|||Interacts with SMAD1. Interacts with SALL4. Interacts with ZNF281/ZFP281 (By similarity). Interacts with PCGF1 (By similarity). Interacts with ESRRB; reciprocally modulates their transcriptional activities. Interacts with NSD2 (By similarity).|||Nucleus|||Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity). http://togogenome.org/gene/9541:NPNT ^@ http://purl.uniprot.org/uniprot/A0A2K5WQS9|||http://purl.uniprot.org/uniprot/A0A2K5WQT3|||http://purl.uniprot.org/uniprot/A0A2K5WR90 ^@ Caution|||Similarity ^@ Belongs to the nephronectin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:SGO2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||centromere http://togogenome.org/gene/9541:LOC102135947 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWN3 ^@ Similarity ^@ Belongs to the histone H2B family. http://togogenome.org/gene/9541:STT3B ^@ http://purl.uniprot.org/uniprot/A0A2K5VVM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/9541:NSUN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||extracellular exosome http://togogenome.org/gene/9541:RPN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UST6|||http://purl.uniprot.org/uniprot/A0A2K5USU9|||http://purl.uniprot.org/uniprot/A0A2K5USZ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWP1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9541:FXYD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBR5 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/9541:S100A6 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4Q2|||http://purl.uniprot.org/uniprot/G7NUG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.|||Nucleus envelope http://togogenome.org/gene/9541:LDHAL6B ^@ http://purl.uniprot.org/uniprot/Q4R816 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9541:UBE2T ^@ http://purl.uniprot.org/uniprot/A0A2K5U653|||http://purl.uniprot.org/uniprot/G7NWE1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:NAPA ^@ http://purl.uniprot.org/uniprot/I7GH32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9541:CEP295 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUG6 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/9541:OTUD7B ^@ http://purl.uniprot.org/uniprot/A0A2K5TTA1|||http://purl.uniprot.org/uniprot/G7NTS2 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:CCDC167 ^@ http://purl.uniprot.org/uniprot/A0A2K5UV61|||http://purl.uniprot.org/uniprot/G7P3D4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GRK7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TV47|||http://purl.uniprot.org/uniprot/G7P015 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9541:ZER1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPV2|||http://purl.uniprot.org/uniprot/G7PRE8 ^@ Similarity ^@ Belongs to the zyg-11 family. http://togogenome.org/gene/9541:LOC107129596 ^@ http://purl.uniprot.org/uniprot/G7P2N0|||http://purl.uniprot.org/uniprot/Q4R362 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.|||Belongs to the histone H4 family.|||Butyrylation of histones marks active promoters and competes with histone acetylation.|||Chromosome|||Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).|||Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.|||Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.|||Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.|||Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).|||Nucleus|||Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).|||Sumoylated, which is associated with transcriptional repression.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).|||Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. http://togogenome.org/gene/9541:GLO1 ^@ http://purl.uniprot.org/uniprot/G7P3D8|||http://purl.uniprot.org/uniprot/Q4R5F2 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the glyoxalase I family.|||Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.|||Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (By similarity). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity). Required for normal osteoclastogenesis (By similarity).|||Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.|||Exists in a nitric oxide (NO)-modified form. The exact nature of the modification is unknown, but it suppresses the TNF-induced transcriptional activity of NF-kappa-B (By similarity).|||Glutathionylation at Cys-139 inhibits enzyme activity.|||Homodimer.|||Phosphorylated at Thr-107 in the presence of CaMK2. However, this is a consensus site for phosphorylation by CK2 so phosphorylation may be mediated by CK2 rather than CaMK2. Phosphorylation is induced by TNF and suppresses the TNF-induced transcriptional activity of NF-kappa-B (By similarity). http://togogenome.org/gene/9541:ZNF215 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTN4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102117046 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUJ1|||http://purl.uniprot.org/uniprot/I7GA11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tollip family.|||Cytoplasm http://togogenome.org/gene/9541:SIDT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUN3|||http://purl.uniprot.org/uniprot/A0A2K5UUN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SID1 family.|||Membrane http://togogenome.org/gene/9541:EPHB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4F3|||http://purl.uniprot.org/uniprot/A0A2K5W4J4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ACP7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEP7|||http://purl.uniprot.org/uniprot/A0A8J8XKK7|||http://purl.uniprot.org/uniprot/G7PXI5 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family. http://togogenome.org/gene/9541:SLX1A ^@ http://purl.uniprot.org/uniprot/A0A2K5TXK1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLX1 family.|||Belongs to the sulfotransferase 1 family.|||Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.|||Forms a heterodimer with SLX4.|||Nucleus http://togogenome.org/gene/9541:ILF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6D2|||http://purl.uniprot.org/uniprot/A0A2K5X6D6|||http://purl.uniprot.org/uniprot/A0A2K5X712 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:RAB8A ^@ http://purl.uniprot.org/uniprot/Q4R5P1 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Cytoplasm|||Golgi apparatus|||Interacts (GTP-bound form) with MICALL1; regulates RAB8A association with recycling endosomes (By similarity). Interacts with MICALL2; competes with RAB13 and is involved in E-cadherin endocytic recycling (By similarity). Interacts (GTP-bound form) with MICAL1, MICALCL, MICAL3 and EHBP1L1; two molecules of RAB8A can bind to one molecule of the effector protein; ternary complexes of RAB8A, RAB13 and either MICAL1 or EHBP1L1 are possible (By similarity). Interacts (GTP-bound form) with EHBP1 (By similarity). Interacts with EHD1 (By similarity). Interacts with MAP4K2 and SYTL4 (By similarity). Interacts with SGSM1 and SGSM3 (By similarity). Interacts with RABIF, RIMS2, RPH3A and RPH3A (By similarity). Interacts with OPTN (By similarity). Interacts with RAB3IP (By similarity). Interacts with MYO5B (By similarity). Interacts with PIFO (By similarity). Interacts with BIRC6/bruce (By similarity). Interacts with OCRL (By similarity). Interacts with AHI1 (By similarity). Interacts with DCDC1 (By similarity). Interacts with LRRK2; interaction facilitates phosphorylation of Thr-72 (By similarity). Interacts with RAB31P, GDI1, GDI2, CHM, CHML, RABGGTA, RABGGTB, TBC1D15 and INPP5B; these interactions are dependent on Thr-72 not being phosphorylated (By similarity). Interacts with RILPL1 and RILPL2; these interactions are dependent on the phosphorylation of Thr-72 by LRRK2 (By similarity). Interacts with DZIP1; prevents inhibition by the GDP-dissociation inhibitor GDI2 (By similarity).|||Midbody|||Phosphorylation of Thr-72 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.|||Recycling endosome membrane|||Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase (By similarity). Activated in response to insulin (By similarity).|||The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Regulates the compacted morphology of the Golgi (By similarity). Together with MYO5B and RAB11A participates in epithelial cell polarization. Also involved in membrane trafficking to the cilium and ciliogenesis (By similarity). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (By similarity).|||centriole|||cilium|||cilium basal body|||phagosome membrane http://togogenome.org/gene/9541:COPZ2 ^@ http://purl.uniprot.org/uniprot/I7GJN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes small subunit family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. http://togogenome.org/gene/9541:CAMSAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7Q2|||http://purl.uniprot.org/uniprot/A0A2K5U7R5 ^@ Domain|||Similarity ^@ Belongs to the CAMSAP1 family.|||The CKK domain binds microtubules. http://togogenome.org/gene/9541:SAA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKU4|||http://purl.uniprot.org/uniprot/A0A7N9IDU3 ^@ Function|||Similarity ^@ Belongs to the SAA family.|||Major acute phase reactant. Apolipoprotein of the HDL complex. http://togogenome.org/gene/9541:SPATA17 ^@ http://purl.uniprot.org/uniprot/Q4R7Z7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:WDR45 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5Q7|||http://purl.uniprot.org/uniprot/A0A2K5V683|||http://purl.uniprot.org/uniprot/A0A2K5V6B4|||http://purl.uniprot.org/uniprot/A0A2K5V6C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PROPPIN family.|||Preautophagosomal structure http://togogenome.org/gene/9541:PRDM15 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2Q5|||http://purl.uniprot.org/uniprot/A0A2K5U2Q8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:HSPA9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSK5 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9541:KRR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TN33|||http://purl.uniprot.org/uniprot/A0A2K5TN62|||http://purl.uniprot.org/uniprot/G7PI30 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KRR1 family.|||Component of the ribosomal small subunit (SSU) processome.|||Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.|||nucleolus http://togogenome.org/gene/9541:SLC17A1 ^@ http://purl.uniprot.org/uniprot/G7P2K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.|||Membrane http://togogenome.org/gene/9541:UGCG ^@ http://purl.uniprot.org/uniprot/A0A2K5WQV5 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/9541:PTH ^@ http://purl.uniprot.org/uniprot/G7PQP2|||http://purl.uniprot.org/uniprot/Q9XT35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the parathyroid hormone family.|||Interacts with PTH1R (via N-terminal extracellular domain).|||PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).|||PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.|||Secreted http://togogenome.org/gene/9541:LLGL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6E0 ^@ Similarity ^@ Belongs to the WD repeat L(2)GL family. http://togogenome.org/gene/9541:SLC16A14 ^@ http://purl.uniprot.org/uniprot/A0A2K5WN05 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:EXOC6B ^@ http://purl.uniprot.org/uniprot/A0A2K5V5C6|||http://purl.uniprot.org/uniprot/A0A2K5V5E9|||http://purl.uniprot.org/uniprot/A0A7N9CB83 ^@ Function|||Similarity ^@ Belongs to the SEC15 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9541:LOC101865054 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPJ1|||http://purl.uniprot.org/uniprot/I7GPL8 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/9541:RSBN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X9Q4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the round spermatid basic protein 1 family.|||Nucleus http://togogenome.org/gene/9541:DKK4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRM2|||http://purl.uniprot.org/uniprot/G7PBR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9541:AATF ^@ http://purl.uniprot.org/uniprot/I7GNX0 ^@ Similarity ^@ Belongs to the AATF family. http://togogenome.org/gene/9541:DNAJC9 ^@ http://purl.uniprot.org/uniprot/G7PF15 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/9541:PEBP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0P4 ^@ Similarity ^@ Belongs to the phosphatidylethanolamine-binding protein family. http://togogenome.org/gene/9541:CENPU ^@ http://purl.uniprot.org/uniprot/A0A2K5VF40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-U/AME1 family.|||Nucleus http://togogenome.org/gene/9541:ECHDC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0C9|||http://purl.uniprot.org/uniprot/G7NVP7 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9541:PDS5A ^@ http://purl.uniprot.org/uniprot/A0A2K5VEZ2 ^@ Similarity ^@ Belongs to the PDS5 family. http://togogenome.org/gene/9541:PER1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VK29 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:AACS ^@ http://purl.uniprot.org/uniprot/Q9N0E1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity).|||cytosol http://togogenome.org/gene/9541:TFDP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5US80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9541:LUM ^@ http://purl.uniprot.org/uniprot/Q4R4R3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.|||Binds to laminin.|||extracellular matrix http://togogenome.org/gene/9541:LSM14A ^@ http://purl.uniprot.org/uniprot/A0A2K5UDB2|||http://purl.uniprot.org/uniprot/A0A2K5UDC8 ^@ Similarity ^@ Belongs to the LSM14 family. http://togogenome.org/gene/9541:CYP4V2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U594 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:TAC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6I4|||http://purl.uniprot.org/uniprot/A0A2K5X6K8|||http://purl.uniprot.org/uniprot/Q2PFW3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted|||Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. http://togogenome.org/gene/9541:UGP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VC98|||http://purl.uniprot.org/uniprot/A0A2K5VCA2|||http://purl.uniprot.org/uniprot/A0A2K5VCC5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/9541:ASF1B ^@ http://purl.uniprot.org/uniprot/A0A2K5VLV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/9541:GPR157 ^@ http://purl.uniprot.org/uniprot/A0A2K5TW36 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:RGS14 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNN0 ^@ Subcellular Location Annotation ^@ dendrite http://togogenome.org/gene/9541:SPIN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U068|||http://purl.uniprot.org/uniprot/A0A8J8XDI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPIN/STSY family.|||Nucleus http://togogenome.org/gene/9541:N4BP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the N4BP3 family.|||Cytoplasmic vesicle|||Vesicle|||axon|||dendrite http://togogenome.org/gene/9541:RPS7 ^@ http://purl.uniprot.org/uniprot/A0A2K5W178 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS7 family.|||Required for rRNA maturation. http://togogenome.org/gene/9541:DIPK2A ^@ http://purl.uniprot.org/uniprot/A0A2K5TMH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/9541:APOM ^@ http://purl.uniprot.org/uniprot/A0A2K5VDN5|||http://purl.uniprot.org/uniprot/G7P4P9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family. Highly divergent.|||Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.|||Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.|||Secreted http://togogenome.org/gene/9541:TBX22 ^@ http://purl.uniprot.org/uniprot/A0A8J8XP92|||http://purl.uniprot.org/uniprot/G7Q341 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:IDH2 ^@ http://purl.uniprot.org/uniprot/Q4R502 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-413 dramatically reduces catalytic activity. Deacetylated by SIRT3 (By similarity).|||Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Homodimer.|||Mitochondrion|||Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex (By similarity). http://togogenome.org/gene/9541:TOMM40 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:CLK4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0K8|||http://purl.uniprot.org/uniprot/A0A2K5X114|||http://purl.uniprot.org/uniprot/A0A7N9CE55 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:SRD5A2 ^@ http://purl.uniprot.org/uniprot/Q28892 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:NT5C3A ^@ http://purl.uniprot.org/uniprot/A0A2K5WTY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/9541:CLTB ^@ http://purl.uniprot.org/uniprot/A0A2K5TU49 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/9541:CD63 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Cell surface|||Endosome membrane|||Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.|||Late endosome membrane|||Lysosome membrane|||Melanosome|||Membrane|||extracellular exosome|||multivesicular body http://togogenome.org/gene/9541:FRZB ^@ http://purl.uniprot.org/uniprot/A0A2K5V9H7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. http://togogenome.org/gene/9541:CCDC142 ^@ http://purl.uniprot.org/uniprot/G7PMJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL53 family.|||Mitochondrion http://togogenome.org/gene/9541:MDH1B ^@ http://purl.uniprot.org/uniprot/A0A2K5VAL2|||http://purl.uniprot.org/uniprot/A0A7N9CNW0 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family. http://togogenome.org/gene/9541:CDK5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYL9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:TFPI ^@ http://purl.uniprot.org/uniprot/A0A2K5UGS2|||http://purl.uniprot.org/uniprot/Q2PFV4 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:WDFY2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0S0 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9541:PLA1A ^@ http://purl.uniprot.org/uniprot/A0A2K5VMJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9541:NINJ1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ninjurin family.|||Membrane http://togogenome.org/gene/9541:LOC102121923 ^@ http://purl.uniprot.org/uniprot/A0A7N9D2F1 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9541:EBAG9 ^@ http://purl.uniprot.org/uniprot/A0A2K5UB51 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. http://togogenome.org/gene/9541:ADHFE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.|||Mitochondrion http://togogenome.org/gene/9541:PGM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVT5|||http://purl.uniprot.org/uniprot/Q4R5E4 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Monomer.|||Phosphorylation at Thr-467 by PAK1 significantly enhances enzymatic activity.|||This enzyme participates in both the breakdown and synthesis of glucose. http://togogenome.org/gene/9541:TRAPPC2L ^@ http://purl.uniprot.org/uniprot/A0A2K5W9L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/9541:LOC102137744 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQP4|||http://purl.uniprot.org/uniprot/G7P2L5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:DGLUCY ^@ http://purl.uniprot.org/uniprot/A0A2K5UUX8 ^@ Similarity ^@ Belongs to the D-glutamate cyclase family. http://togogenome.org/gene/9541:LOC102136165 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/9541:LRP6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCG3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDLR family.|||Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.|||Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PLSCR5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUH6 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9541:TIMP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNU0 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/9541:CHMP4B ^@ http://purl.uniprot.org/uniprot/A0A2K5WZD2 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9541:CYSLTR2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CNM6|||http://purl.uniprot.org/uniprot/G7PVE4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:PSEN1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDD5|||http://purl.uniprot.org/uniprot/G7PAT1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Cytoplasmic granule|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||Synapse|||The PAL motif is required for normal active site conformation.|||axon|||neuron projection http://togogenome.org/gene/9541:KEG98_p08 ^@ http://purl.uniprot.org/uniprot/C3W4Z0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:VAMP2 ^@ http://purl.uniprot.org/uniprot/I7GCX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9541:DEFB132 ^@ http://purl.uniprot.org/uniprot/A4H265|||http://purl.uniprot.org/uniprot/G7PGQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:CHRNE ^@ http://purl.uniprot.org/uniprot/A0A2K5UB32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:HOOK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hook family.|||cytoskeleton http://togogenome.org/gene/9541:CRY1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQ28|||http://purl.uniprot.org/uniprot/G7PI44 ^@ Similarity ^@ Belongs to the DNA photolyase class-1 family. http://togogenome.org/gene/9541:TNNT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBC9|||http://purl.uniprot.org/uniprot/A0A2K5WBM2|||http://purl.uniprot.org/uniprot/A0A2K5WBM8|||http://purl.uniprot.org/uniprot/A0A2K5WBT9 ^@ Function|||Similarity ^@ Belongs to the troponin T family.|||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/9541:PUS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSS2 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/9541:SERPINA11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTE5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:UBE2G1 ^@ http://purl.uniprot.org/uniprot/Q4R5Y8 ^@ Function|||PTM|||Similarity ^@ Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.|||Autoubiquitinated.|||Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:LOC102135406 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQK1 ^@ Function|||Similarity ^@ Belongs to the globin family.|||The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin. http://togogenome.org/gene/9541:SNX31 ^@ http://purl.uniprot.org/uniprot/A0A2K5U622 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9541:LOC102144088 ^@ http://purl.uniprot.org/uniprot/A0A7N9CH16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:POLR2B ^@ http://purl.uniprot.org/uniprot/A0A2K5VZA8|||http://purl.uniprot.org/uniprot/G7P5R6 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/9541:SDR42E1 ^@ http://purl.uniprot.org/uniprot/G7PZU6|||http://purl.uniprot.org/uniprot/Q4R7R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 3-beta-HSD family.|||Membrane http://togogenome.org/gene/9541:KRT79 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDL3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:OSBPL10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRP9|||http://purl.uniprot.org/uniprot/A0A2K5WRR9 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9541:CD38 ^@ http://purl.uniprot.org/uniprot/G7P5B0|||http://purl.uniprot.org/uniprot/Q5VAN0 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP inhibits the hydrolyzing activity.|||Belongs to the ADP-ribosyl cyclase family.|||Membrane|||Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system (By similarity). http://togogenome.org/gene/9541:PSMA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6A0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9541:ADM ^@ http://purl.uniprot.org/uniprot/A0A2K5TTY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adrenomedullin family.|||Secreted http://togogenome.org/gene/9541:CHORDC1 ^@ http://purl.uniprot.org/uniprot/Q4R7U2 ^@ Function|||Subunit ^@ Interacts with HSP90AA1, HSP90AB1, PPP5C, ROCK1 and ROCK2.|||Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (By similarity). Involved in stress response. Prevents tumorigenesis (By similarity). http://togogenome.org/gene/9541:ABAT ^@ http://purl.uniprot.org/uniprot/A0A2K5UZZ0|||http://purl.uniprot.org/uniprot/G7Q0G5 ^@ Similarity|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9541:CA12 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSA5|||http://purl.uniprot.org/uniprot/A0A2K5TSB2|||http://purl.uniprot.org/uniprot/A0A2K5TSC4|||http://purl.uniprot.org/uniprot/A0A7N9IEH5 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9541:ORC6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC6 family.|||Nucleus http://togogenome.org/gene/9541:PCK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHT3 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/9541:MS4A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXS6|||http://purl.uniprot.org/uniprot/G7PQ10 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9541:NIBAN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPU1 ^@ Similarity ^@ Belongs to the Niban family. http://togogenome.org/gene/9541:IFNAR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGY1|||http://purl.uniprot.org/uniprot/A0A7N9D7J0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II cytokine receptor family.|||Cell membrane|||Endosome|||Heterodimer with IFNAR2.|||Late endosome|||Lysosome|||Membrane|||Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. http://togogenome.org/gene/9541:AMIGO3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMB3 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. AMIGO family. http://togogenome.org/gene/9541:IGFBP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZA4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:RGS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTX1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:VPS13B ^@ http://purl.uniprot.org/uniprot/A0A2K5WHQ8|||http://purl.uniprot.org/uniprot/A0A2K5WHZ8 ^@ Similarity ^@ Belongs to the VPS13 family. http://togogenome.org/gene/9541:FGR ^@ http://purl.uniprot.org/uniprot/A0A2K5WJL3|||http://purl.uniprot.org/uniprot/A0A7N9CQJ0|||http://purl.uniprot.org/uniprot/G7NWU6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9541:POLD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0C6|||http://purl.uniprot.org/uniprot/A0A8J8YHG8|||http://purl.uniprot.org/uniprot/Q4R5Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase delta/II small subunit family.|||Nucleus http://togogenome.org/gene/9541:FUBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V069|||http://purl.uniprot.org/uniprot/A0A7N9D6Y9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:EI24 ^@ http://purl.uniprot.org/uniprot/A0A2K5VD06|||http://purl.uniprot.org/uniprot/A0A2K5VD62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EI24 family.|||Membrane http://togogenome.org/gene/9541:MRPS11 ^@ http://purl.uniprot.org/uniprot/I7GJD7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/9541:SLC15A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V056|||http://purl.uniprot.org/uniprot/G7NXR2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/9541:LOC102120872 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIV2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:USB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCV2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2H phosphoesterase superfamily. USB1 family.|||Nucleus|||Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. http://togogenome.org/gene/9541:CDCA7L ^@ http://purl.uniprot.org/uniprot/A0A2K5TT79 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:DNASE1L3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYE2|||http://purl.uniprot.org/uniprot/G7NZC1 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9541:STK40 ^@ http://purl.uniprot.org/uniprot/I7GC38 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.|||Nucleus http://togogenome.org/gene/9541:LOC102128567 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TAF15 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/9541:PGLYRP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6T5 ^@ Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. http://togogenome.org/gene/9541:LOC107126377 ^@ http://purl.uniprot.org/uniprot/A0A8U0WQ25|||http://purl.uniprot.org/uniprot/G8F3V0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:TSPAN7 ^@ http://purl.uniprot.org/uniprot/Q4R5A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:NDUFB6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNL0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB6 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ZDHHC24 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6Y0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:LOC102133217 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9Q7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:CFAP300 ^@ http://purl.uniprot.org/uniprot/A0A2K5WC47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP300 family.|||Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.|||Cytoplasm http://togogenome.org/gene/9541:RPLP0 ^@ http://purl.uniprot.org/uniprot/I7GJL8 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Ribosomal protein P0 is the functional equivalent of E.coli protein L10. http://togogenome.org/gene/9541:LANCL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVY4|||http://purl.uniprot.org/uniprot/A0A2K5VWA1|||http://purl.uniprot.org/uniprot/G7PLC1 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/9541:UNC45A ^@ http://purl.uniprot.org/uniprot/A0A2K5W2E7|||http://purl.uniprot.org/uniprot/G7P9H1 ^@ Subcellular Location Annotation ^@ perinuclear region http://togogenome.org/gene/9541:SULT1B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZW5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9541:STRA6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNK7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:CYP3A7 ^@ http://purl.uniprot.org/uniprot/B1Q2L6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:CYP2C19 ^@ http://purl.uniprot.org/uniprot/Q0HA19 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:ZPR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQF6 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/9541:CELF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0L7|||http://purl.uniprot.org/uniprot/A0A2K5X0M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:ALDH3A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZN9|||http://purl.uniprot.org/uniprot/A0A2K5UZP3|||http://purl.uniprot.org/uniprot/Q60HH8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.|||Endoplasmic reticulum membrane|||Homodimer.|||Microsome membrane http://togogenome.org/gene/9541:C14H11orf68 ^@ http://purl.uniprot.org/uniprot/A0A2K5V960 ^@ Similarity ^@ Belongs to the UPF0696 family. http://togogenome.org/gene/9541:MAST1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUP4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9541:ATP9B ^@ http://purl.uniprot.org/uniprot/A0A2K5VBT6|||http://purl.uniprot.org/uniprot/A0A2K5VBZ6|||http://purl.uniprot.org/uniprot/A0A2K5VC06|||http://purl.uniprot.org/uniprot/A0A7N9CZH0|||http://purl.uniprot.org/uniprot/A0A7N9D7E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9541:PRR15L ^@ http://purl.uniprot.org/uniprot/A0A2K5UP02|||http://purl.uniprot.org/uniprot/G8F625 ^@ Similarity ^@ Belongs to the PRR15 family. http://togogenome.org/gene/9541:PLPP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UR95|||http://purl.uniprot.org/uniprot/A0A2K5URB3|||http://purl.uniprot.org/uniprot/A0A7N9IE10 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the PA-phosphatase related phosphoesterase family.|||Cell membrane|||Membrane|||Membrane raft|||caveola http://togogenome.org/gene/9541:CALHM4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9541:GPR132 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAF1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:RBBP7 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4H5|||http://purl.uniprot.org/uniprot/G7Q2B1|||http://purl.uniprot.org/uniprot/Q4R304 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.|||Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin. Subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SUDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex. The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylase complex (the NuRD complex). The NuRD complex may also interact with MBD3L1 and MBD3L2. Interacts with MTA1. Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12. The PRC2/EED-EZH2 complex may also associate with HDAC1. Component of the NURF-1 ISWI chromatin remodeling complex (also called the nucleosome-remodeling factor (NURF) complex) at least composed of SMARCA1; BPTF; RBBP4 and RBBP7 (By similarity). Within the complex interacts with SMARCA1 (By similarity). Interacts with the viral protein-binding domain of the retinoblastoma protein (RB1). Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP. Interacts with CENPA. Interacts with BRCA1, HDAC7 and SUV39H1 (By similarity). Interacts with PWWP2B (By similarity).|||Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex (By similarity).|||Nucleus http://togogenome.org/gene/9541:SNAPIN ^@ http://purl.uniprot.org/uniprot/A0A2K5W620 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAPIN family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.|||synaptic vesicle membrane http://togogenome.org/gene/9541:EIF4G3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VA69|||http://purl.uniprot.org/uniprot/A0A2K5VA93|||http://purl.uniprot.org/uniprot/A0A2K5VAD7|||http://purl.uniprot.org/uniprot/A0A2K5VAF8|||http://purl.uniprot.org/uniprot/A0A7N9DBY5 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4G family. http://togogenome.org/gene/9541:ERCC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZM7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TM4SF20 ^@ http://purl.uniprot.org/uniprot/A0A2K5WG70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9541:PLXNB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBD0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:KCTD6 ^@ http://purl.uniprot.org/uniprot/A0A8J8YEU1|||http://purl.uniprot.org/uniprot/G7NZB5 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:PRM1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XIC9|||http://purl.uniprot.org/uniprot/G7Q0H9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protamine P1 family.|||Chromosome|||Nucleus|||Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. http://togogenome.org/gene/9541:DIP2A ^@ http://purl.uniprot.org/uniprot/A0A2K5WH50 ^@ Similarity ^@ Belongs to the DIP2 family. http://togogenome.org/gene/9541:NUP62 ^@ http://purl.uniprot.org/uniprot/Q4R513 ^@ Similarity ^@ Belongs to the nucleoporin NSP1/NUP62 family. http://togogenome.org/gene/9541:SRPX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VS42 ^@ Caution|||Subcellular Location Annotation ^@ Cell surface|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Synapse http://togogenome.org/gene/9541:CUTC ^@ http://purl.uniprot.org/uniprot/A0A8J8XRE7|||http://purl.uniprot.org/uniprot/G7PDQ4 ^@ Similarity ^@ Belongs to the CutC family. http://togogenome.org/gene/9541:AVPI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGI2 ^@ Function ^@ May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling. http://togogenome.org/gene/9541:POFUT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTE3|||http://purl.uniprot.org/uniprot/I7GHN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 65 family.|||Endoplasmic reticulum http://togogenome.org/gene/9541:RPS27L ^@ http://purl.uniprot.org/uniprot/A0A2K5X425 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9541:MED17 ^@ http://purl.uniprot.org/uniprot/I7GJG6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 17 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9541:TM2D3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UII3|||http://purl.uniprot.org/uniprot/A0A2K5UIJ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:HIPK4 ^@ http://purl.uniprot.org/uniprot/Q8WP28 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Autophosphorylated.|||Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.|||Cytoplasm|||Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). http://togogenome.org/gene/9541:CBLL2 ^@ http://purl.uniprot.org/uniprot/Q4R361 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates.|||Homodimer.|||The HYB domain forms a phosphotyrosine-binding pocket upon dimerization, and mediates as well the recognition of its flanking acidic amino acids. http://togogenome.org/gene/9541:POLA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTK6 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/9541:CCDC89 ^@ http://purl.uniprot.org/uniprot/Q95JI9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC89 family.|||Cytoplasm|||Interacts with HEY1.|||Nucleus http://togogenome.org/gene/9541:LOC101926570 ^@ http://purl.uniprot.org/uniprot/I7GEY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9541:IL36RN ^@ http://purl.uniprot.org/uniprot/A0A2K5UWR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9541:TSPO ^@ http://purl.uniprot.org/uniprot/A0A2K5TLZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9541:NUBPL ^@ http://purl.uniprot.org/uniprot/A0A8J8XZC4|||http://purl.uniprot.org/uniprot/G7PA18 ^@ Similarity ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. http://togogenome.org/gene/9541:CPSF2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YIL5|||http://purl.uniprot.org/uniprot/G7PBB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/9541:LOC102137613 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7T7 ^@ Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family. http://togogenome.org/gene/9541:DRC7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WM21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC7 family.|||cilium axoneme|||flagellum|||flagellum axoneme http://togogenome.org/gene/9541:MYF6 ^@ http://purl.uniprot.org/uniprot/A0A8J8YFV7|||http://purl.uniprot.org/uniprot/G7PIK1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:AK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0D6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK1 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9541:GDI1 ^@ http://purl.uniprot.org/uniprot/A0A158SIP6|||http://purl.uniprot.org/uniprot/Q8HXX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Interacts with RHOH (By similarity). Interacts with the non-phosphorylated forms of RAB1A, RAB3A, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (By similarity).|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.|||Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes (By similarity).|||trans-Golgi network http://togogenome.org/gene/9541:SLC46A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFE1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SLC6A12 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNR4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.|||Interacts with LIN7C.|||Membrane|||Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. http://togogenome.org/gene/9541:EFEMP1 ^@ http://purl.uniprot.org/uniprot/Q7YQD7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the fibulin family.|||Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth (By similarity).|||Interacts with ECM1. Interacts with TIMP3.|||extracellular matrix|||extracellular space http://togogenome.org/gene/9541:CXCL11 ^@ http://purl.uniprot.org/uniprot/A0A8J8XWC3|||http://purl.uniprot.org/uniprot/G7P556 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9541:DCK ^@ http://purl.uniprot.org/uniprot/Q4R5R5 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9541:RPL30 ^@ http://purl.uniprot.org/uniprot/A0A158SIP2|||http://purl.uniprot.org/uniprot/Q76KA2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL30 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm http://togogenome.org/gene/9541:SLCO6A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXZ1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:SURF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTP9|||http://purl.uniprot.org/uniprot/A0A7N9CUS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF4 family.|||Membrane http://togogenome.org/gene/9541:POLH ^@ http://purl.uniprot.org/uniprot/A0A2K5VUR0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FAM174A ^@ http://purl.uniprot.org/uniprot/A0A2K5V3R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/9541:LOC102131133 ^@ http://purl.uniprot.org/uniprot/A0A2K5WE79|||http://purl.uniprot.org/uniprot/G7P6C8 ^@ Caution|||Similarity ^@ Belongs to the HHIP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:FAM161A ^@ http://purl.uniprot.org/uniprot/A0A2K5ULS5|||http://purl.uniprot.org/uniprot/A0A2K5ULT2 ^@ Similarity ^@ Belongs to the FAM161 family. http://togogenome.org/gene/9541:MBOAT4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102127963 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIM1|||http://purl.uniprot.org/uniprot/G7PUR5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:DHX58 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGV9|||http://purl.uniprot.org/uniprot/A0A2K5WGW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9541:MAP2K3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJP6|||http://purl.uniprot.org/uniprot/A0A2K5WJZ8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:MRPL3 ^@ http://purl.uniprot.org/uniprot/G7NXZ9|||http://purl.uniprot.org/uniprot/I7GKE3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/9541:LOC102128939 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:RPL21 ^@ http://purl.uniprot.org/uniprot/A0A2K5UG77|||http://purl.uniprot.org/uniprot/G7PVW5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9541:MNDA ^@ http://purl.uniprot.org/uniprot/Q8SPH9 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Its N-terminal half (200 amino acids) is sufficient for maximum enhancement of YY1 DNA binding and a portion of this sequence is responsible for binding YY1.|||May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1 (By similarity).|||Nucleus|||Participates in a ternary complex with YY1 and the YY1 target DNA element. Binds nucleolin and nucleophosmin/NPM/B23 (By similarity). http://togogenome.org/gene/9541:APAF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3C3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Monomer. Oligomerizes upon binding of cytochrome c and dATP.|||Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. http://togogenome.org/gene/9541:LHFPL6 ^@ http://purl.uniprot.org/uniprot/I7GNY1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ACTRT2 ^@ http://purl.uniprot.org/uniprot/Q4R317 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||cytoskeleton http://togogenome.org/gene/9541:NCBP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ59 ^@ Similarity ^@ Belongs to the NCBP3 family. http://togogenome.org/gene/9541:GSTM2 ^@ http://purl.uniprot.org/uniprot/Q9TSM4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GST superfamily. Mu family.|||Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers (By similarity). Has activity toward aflatoxin B(1)-8,9-epoxide (AFBO) (PubMed:10869451).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9541:CASP6 ^@ http://purl.uniprot.org/uniprot/G7P629 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C14A family.|||Cytoplasm|||Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit.|||Nucleus http://togogenome.org/gene/9541:LOC102126517 ^@ http://purl.uniprot.org/uniprot/A0A7N9D902 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9541:CHST9 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJL9|||http://purl.uniprot.org/uniprot/A0A8J8YFQ8|||http://purl.uniprot.org/uniprot/G7PWJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:XG ^@ http://purl.uniprot.org/uniprot/A0A2K5UP34 ^@ Similarity ^@ Belongs to the CD99 family. http://togogenome.org/gene/9541:POLR1B ^@ http://purl.uniprot.org/uniprot/A0A2K5V5H3|||http://purl.uniprot.org/uniprot/G7PMZ1 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft. http://togogenome.org/gene/9541:DEFA6 ^@ http://purl.uniprot.org/uniprot/A0A8J8YGN9|||http://purl.uniprot.org/uniprot/G7PCC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-defensin family.|||Secreted http://togogenome.org/gene/9541:HDDC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAF6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HDDC2 family.|||Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).|||Homodimer. http://togogenome.org/gene/9541:IL2RA ^@ http://purl.uniprot.org/uniprot/H6WS54 ^@ Caution|||Function|||Subunit ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.|||Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. http://togogenome.org/gene/9541:MOB3C ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ90|||http://purl.uniprot.org/uniprot/G7NVL8 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9541:EIF3M ^@ http://purl.uniprot.org/uniprot/A0A2K5TRB4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Belongs to the eIF-3 subunit M family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9541:B4GALT6 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5Q0|||http://purl.uniprot.org/uniprot/A0A2K5V5W8|||http://purl.uniprot.org/uniprot/A0A2K5V5Z4|||http://purl.uniprot.org/uniprot/A0A8J8Y1F8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9541:FAAH2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YRN5|||http://purl.uniprot.org/uniprot/G7Q2V7 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/9541:STOML2 ^@ http://purl.uniprot.org/uniprot/G7PS14 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9541:MCHR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VT41 ^@ Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Interacts with NCDN.|||Membrane http://togogenome.org/gene/9541:TFB1M ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2R5|||http://purl.uniprot.org/uniprot/G7P4X1|||http://purl.uniprot.org/uniprot/Q2PG46 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.|||Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM (By similarity).|||Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.|||Mitochondrion|||S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity).|||S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. http://togogenome.org/gene/9541:CDH5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSK2 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell junction|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ARMC1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XP95|||http://purl.uniprot.org/uniprot/G7PBX8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:ING1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJB7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9541:SMAD4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZF7|||http://purl.uniprot.org/uniprot/G7PWS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:ALG5 ^@ http://purl.uniprot.org/uniprot/A0A8J8YEI8|||http://purl.uniprot.org/uniprot/G7PW14 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/9541:YIPF5 ^@ http://purl.uniprot.org/uniprot/I7GM50|||http://purl.uniprot.org/uniprot/Q4R5M4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YIP1 family.|||COPII-coated vesicle|||Endoplasmic reticulum membrane|||Interacts with the COPII coat components Sec23 (SEC23A and/or SEC23B) and Sec24 (SEC24A and/or SEC24B) (By similarity). Interacts with YIF1A (By similarity). May interact with RAB1A (By similarity). Interacts with YIPF3 and YIPF4 (By similarity).|||Membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. In pancreatic beta cells, required to transport proinsulin from endoplasmic reticulum into the Golgi.|||cis-Golgi network membrane http://togogenome.org/gene/9541:RNASE7 ^@ http://purl.uniprot.org/uniprot/A0A7N9D1I0 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9541:LEPROT ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/9541:ATP23 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXC9 ^@ Similarity ^@ Belongs to the peptidase M76 family. http://togogenome.org/gene/9541:AGTPBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X501|||http://purl.uniprot.org/uniprot/G7PSM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||cytosol http://togogenome.org/gene/9541:APLP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNL8|||http://purl.uniprot.org/uniprot/Q4R4M8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:NNT ^@ http://purl.uniprot.org/uniprot/A0A2K5WQE6|||http://purl.uniprot.org/uniprot/G7P7G8 ^@ Similarity ^@ In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/9541:LOC102121007 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5R5|||http://purl.uniprot.org/uniprot/Q4R791 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:FOXN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVX4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TNMD ^@ http://purl.uniprot.org/uniprot/A0A8J8YP78|||http://purl.uniprot.org/uniprot/G7Q376 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/9541:DGUOK ^@ http://purl.uniprot.org/uniprot/A0A2K5VPR5|||http://purl.uniprot.org/uniprot/A0A8J8Y974|||http://purl.uniprot.org/uniprot/G7PMI3 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9541:ATP13A5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEC5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:NPRL2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XVQ8|||http://purl.uniprot.org/uniprot/G7NXS3 ^@ Similarity ^@ Belongs to the NPR2 family. http://togogenome.org/gene/9541:KIF6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X048 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:SPAG7 ^@ http://purl.uniprot.org/uniprot/I7G600 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102129319 ^@ http://purl.uniprot.org/uniprot/A0A2K5UE83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:FNIP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U626 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNIP family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9541:HMGN2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YAJ5|||http://purl.uniprot.org/uniprot/G7NXM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9541:CNOT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHU3|||http://purl.uniprot.org/uniprot/A0A2K5WI09|||http://purl.uniprot.org/uniprot/A0A8J8XFT7|||http://purl.uniprot.org/uniprot/G7PI14 ^@ Similarity ^@ Belongs to the CNOT2/3/5 family. http://togogenome.org/gene/9541:PLA2G4F ^@ http://purl.uniprot.org/uniprot/A0A2K5WML9 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9541:SCD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2B7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/9541:MAGI3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9541:EIF4A3 ^@ http://purl.uniprot.org/uniprot/Q4R3Q1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly. Involved in craniofacial development.|||Belongs to the DEAD box helicase family. eIF4A subfamily.|||Cytoplasm|||Identified in the spliceosome C complex. Core component of the mRNA splicing-dependent exon junction complex (EJC); the core complex contains CASC3, EIF4A3, MAGOH or MAGOHB, and RBM8A. Interacts with CASC3, MAGOH, NXF1, RBM8A and ALYREF/THOC4. May interact with NOM1. Interacts with POLDIP3. Interacts with CWC22 and PRPF19 in an RNA-independent manner. Direct interaction with CWC22 is mediated by the helicase C-terminal domain. Full interaction with CWC22 occurs only when EIF4A3 is not part of the EJC and prevents EIF4A3 binding to RNA. Identified in a complex composed of the EJC core, UPF3B and UPF2. The EJC core can also interact with UPF3A (in vitro). Interacts with NCBP3 (By similarity). Interacts with NRDE2 (By similarity). Interacts with DHX34; the interaction is RNA-independent (By similarity).|||Nucleus|||Nucleus speckle|||The ATPase activity is increased some 4-fold in the presence of RNA. http://togogenome.org/gene/9541:NRDE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAL1 ^@ Similarity ^@ Belongs to the NRDE2 family. http://togogenome.org/gene/9541:TOR2A ^@ http://purl.uniprot.org/uniprot/A0A2K5VHH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9541:LIPG ^@ http://purl.uniprot.org/uniprot/A0A2K5TPF3|||http://purl.uniprot.org/uniprot/G8F3E1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:TOR1A ^@ http://purl.uniprot.org/uniprot/Q60HG2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Cytoplasmic vesicle membrane|||Endoplasmic reticulum lumen|||Homohexamer. Interacts with TOR1B; the interaction may be specific of neural tissues. Interacts (ATP-bound) with TOR1AIP1 and TOR1AIP2; the interactions induce ATPase activity. Interacts with KLHL14; preferentially when ATP-free. Interacts with KLC1 (via TPR repeats); the interaction associates TOR1A with the kinesin oligomeric complex. Interacts with COPS4; the interaction associates TOR1A with the CSN complex. Interacts with SNAPIN; the interaction is direct and associates SNAPIN with the CSN complex. Interacts with STON2. Interacts (ATP-bound) with SYNE3 (via KASH domain); the interaction is required for SYNE3 nuclear envelope localization. Interacts with VIM; the interaction associates TOR1A with the cytoskeleton. Interacts with PLEC. Interacts (ATP-bound) with SLC6A3; regulates SLC6A3 transport to the plasma membrane (By similarity).|||N-glycosylated.|||Nucleus membrane|||Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues (By similarity).|||cytoskeleton|||growth cone|||secretory vesicle|||synaptic vesicle http://togogenome.org/gene/9541:SPDYA ^@ http://purl.uniprot.org/uniprot/A0A7N9CX77|||http://purl.uniprot.org/uniprot/A0A8J8YGP1|||http://purl.uniprot.org/uniprot/G7PLY1 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/9541:MELK ^@ http://purl.uniprot.org/uniprot/A0A2K5X6B1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/9541:MFAP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XU30|||http://purl.uniprot.org/uniprot/Q4R7A1 ^@ Function|||Similarity ^@ Belongs to the MFAP1 family.|||Involved in pre-mRNA splicing as a component of the spliceosome. http://togogenome.org/gene/9541:GMDS ^@ http://purl.uniprot.org/uniprot/I7GL28 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. http://togogenome.org/gene/9541:XRN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3C7|||http://purl.uniprot.org/uniprot/A0A2K5V3D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-3' exonuclease family.|||Cytoplasm http://togogenome.org/gene/9541:CNOT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VB84|||http://purl.uniprot.org/uniprot/A0A2K5VBD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT1 family.|||Nucleus http://togogenome.org/gene/9541:ITGB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHU8|||http://purl.uniprot.org/uniprot/A0A2K5WHW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Cell surface|||Melanosome|||Membrane|||Recycling endosome|||focal adhesion|||invadopodium membrane|||lamellipodium|||ruffle membrane http://togogenome.org/gene/9541:NCOA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UID3|||http://purl.uniprot.org/uniprot/A0A2K5UIE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/9541:HYPK ^@ http://purl.uniprot.org/uniprot/Q2PFU1 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Component of several N-terminal acetyltransferase complexes (By similarity). Inhibits the N-terminal acetylation activity of the N-terminal acetyltransferase NAA10-NAA15 complex (also called the NatA complex) (By similarity). Has chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT in neuronal cells probably while associated with the NatA complex (By similarity). May play a role in the NatA complex-mediated N-terminal acetylation of PCNP (By similarity).|||Component of the N-terminal acetyltransferase A (NatA)/HYPK complex at least composed of NAA10, NAA15 and HYPK, which has N-terminal acetyltransferase activity (By similarity). Within the complex interacts with NAA10 (By similarity). Within the complex interacts with NAA15 (By similarity). Predominantly interacts with NAA15 in the NAA10-NAA15 complex (also called the NatA complex); the interaction with the NatA complex reduces the acetylation activity of the NatA complex (By similarity). Interacts with HTT (via N-terminus) (By similarity). The NatA complex is required for HYPK stability and for reducing polyQ aggregation of HTT (By similarity). Component of the N-terminal acetyltransferase E (NatE)/HYPK complex at least composed of NAA10, NAA15, NAA50 and HYPK (By similarity). Within the complex interacts with NAA10 and NAA15 (By similarity). Does not interact with NAA50 (By similarity). Interaction with NAA15 reduces the capacity of NAA15 to interact with NAA50 (By similarity). Its capacity to interact with the NatA complex is reduced by NAA50 (By similarity). Does not interact with the N-terminal acetyltransferase B (NatB) complex component NAA25 or the N-terminal acetyltransferase C (NatC) complex component NAA35 (By similarity).|||Cytoplasm|||Nucleus|||Regulator of the N-terminal acetyltransferase NAA10-NAA15 complex, however it is unclear if it acts as an activator or inhibitor of the complex (By similarity). Has been shown in one study to be required for efficient N-terminal acetylation of NAA10-NAA15 complex substrates in vivo and in vitro (By similarity). Another study, however, has shown that it acts in vitro as an inhibitor of NAA10-NAA15 complex-mediated N-terminal acetylation (By similarity). http://togogenome.org/gene/9541:L1CAM ^@ http://purl.uniprot.org/uniprot/A0A2K5UR40|||http://purl.uniprot.org/uniprot/A0A2K5UR71|||http://purl.uniprot.org/uniprot/A0A2K5URA1|||http://purl.uniprot.org/uniprot/A0A2K5URB5 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. http://togogenome.org/gene/9541:KRTCAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WII0|||http://purl.uniprot.org/uniprot/G8F698 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KRTCAP2 family.|||Membrane http://togogenome.org/gene/9541:MGAT4D ^@ http://purl.uniprot.org/uniprot/A0A2K5W3K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 54 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:GSG1L2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/9541:DDAH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPG8 ^@ Function|||Similarity ^@ Belongs to the DDAH family.|||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. http://togogenome.org/gene/9541:CCL20 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:CYP4A11 ^@ http://purl.uniprot.org/uniprot/A8CBR2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:LOC102125097 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJG5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9541:SLC39A9 ^@ http://purl.uniprot.org/uniprot/A0A2K5URI7|||http://purl.uniprot.org/uniprot/A0A2K5URK1|||http://purl.uniprot.org/uniprot/A0A8J8XNJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||May act as a zinc-influx transporter.|||Membrane http://togogenome.org/gene/9541:L3MBTL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJT6|||http://purl.uniprot.org/uniprot/A0A2K5TJX0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MFN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRH2|||http://purl.uniprot.org/uniprot/A0A8J8YMS9|||http://purl.uniprot.org/uniprot/G7NU65|||http://purl.uniprot.org/uniprot/Q4R5A0 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:RAF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKH0|||http://purl.uniprot.org/uniprot/A0A2K5WKV3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/9541:LOC102146388 ^@ http://purl.uniprot.org/uniprot/G7PZ42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:HIF1A ^@ http://purl.uniprot.org/uniprot/A0A2K5V188|||http://purl.uniprot.org/uniprot/Q4R658 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus speckle http://togogenome.org/gene/9541:SERPINB9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ63 ^@ Similarity ^@ Belongs to the serpin family. Ov-serpin subfamily. http://togogenome.org/gene/9541:ATF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X782 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family.|||Nucleus http://togogenome.org/gene/9541:CHEK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAE9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. http://togogenome.org/gene/9541:ATP5F1D ^@ http://purl.uniprot.org/uniprot/A0A2K5X1V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase epsilon chain family.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:LDB2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y9Y1|||http://purl.uniprot.org/uniprot/Q4R522 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/9541:BOLA1 ^@ http://purl.uniprot.org/uniprot/G7NTR8 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/9541:GINS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U021 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS2/PSF2 family.|||Chromosome|||Component of the GINS complex.|||Nucleus http://togogenome.org/gene/9541:OLFM4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPK5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:NIPAL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBH5|||http://purl.uniprot.org/uniprot/A0A8J8XE03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9541:USP20 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWN8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP20/USP33 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||centrosome|||perinuclear region http://togogenome.org/gene/9541:SMIM5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGL0|||http://purl.uniprot.org/uniprot/A0A7N9CHX2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:FAT4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X9C2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:UTP11 ^@ http://purl.uniprot.org/uniprot/A0A8J8YJG7|||http://purl.uniprot.org/uniprot/G7NUB4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/9541:DDX50 ^@ http://purl.uniprot.org/uniprot/A0A2K5VK31 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. http://togogenome.org/gene/9541:ABI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYX9|||http://purl.uniprot.org/uniprot/A0A2K5UYY2|||http://purl.uniprot.org/uniprot/A0A2K5UZ16|||http://purl.uniprot.org/uniprot/A0A2K5UZ21|||http://purl.uniprot.org/uniprot/A0A2K5UZ55|||http://purl.uniprot.org/uniprot/Q2PFU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9541:RACK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEN4|||http://purl.uniprot.org/uniprot/Q4R7Y4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.|||Cell membrane|||Cytoplasm|||Interacts with CPNE3 (By similarity). May interact with ABCB4 (By similarity). Component of the small (40S) ribosomal subunit. Exists as a monomer and also forms oligomers. Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4, KRT1 and OTUB1. Interacts with SRC (via SH2 domain); the interaction is enhanced by tyrosine phosphorylation of RACK1. Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and PRKCA. Interacts with AR. Interacts with IGF1R but not with INSR. Interacts with ADAM12. Interacts with CLEC1B (via N-terminal region) and with HIF1A; the interaction promotes their degradation. Interacts with RHOA; this enhances RHOA activation and promotes cell migration. Interacts with CHRM2; the interaction regulates CHRM2 internalization. Interacts with TRPM6 (via kinase domain). Interacts with PTK2/FAK1; required for PTK2/FAK1 phosphorylation and dephosphorylation. Interacts with FLT1. Interacts with HRAS. Interacts with LARP4B. Interacts with PKD2L1 (By similarity).|||Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration (By similarity). Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (By similarity).|||Nucleus|||Perikaryon|||Phosphorylated on Tyr-228 and/or Tyr-246 by SRC. This is required for binding to SRC (By similarity).|||dendrite|||perinuclear region http://togogenome.org/gene/9541:CRY2 ^@ http://purl.uniprot.org/uniprot/G7PQC1 ^@ Similarity ^@ Belongs to the DNA photolyase class-1 family. http://togogenome.org/gene/9541:GLB1 ^@ http://purl.uniprot.org/uniprot/Q60HF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 35 family.|||Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.|||Homodimer. May form higher multimers.|||Lysosome http://togogenome.org/gene/9541:BICD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2M3|||http://purl.uniprot.org/uniprot/A0A2K5U2M8 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/9541:TAS2R1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9541:RNASE11 ^@ http://purl.uniprot.org/uniprot/G7P9L6 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9541:BAZ2B ^@ http://purl.uniprot.org/uniprot/A0A2K5X261|||http://purl.uniprot.org/uniprot/A0A2K5X267 ^@ Similarity ^@ Belongs to the WAL family. http://togogenome.org/gene/9541:TM4SF18 ^@ http://purl.uniprot.org/uniprot/A0A7N9CA86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9541:PHKA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLC1|||http://purl.uniprot.org/uniprot/G7Q2B7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. http://togogenome.org/gene/9541:SSR3 ^@ http://purl.uniprot.org/uniprot/I7G2K4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-gamma family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9541:LRRC8D ^@ http://purl.uniprot.org/uniprot/A0A7N9CFD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:HTR2B ^@ http://purl.uniprot.org/uniprot/A0A2K5WA17 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts (via C-terminus) with MPDZ.|||Membrane|||synaptosome http://togogenome.org/gene/9541:LOC102115969 ^@ http://purl.uniprot.org/uniprot/A0A8J8YAJ5|||http://purl.uniprot.org/uniprot/G7NXM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9541:ALKBH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TU74 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9541:YWHAZ ^@ http://purl.uniprot.org/uniprot/A0A8J8Y9Q2|||http://purl.uniprot.org/uniprot/G7PCF6 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9541:NANOS3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CX74 ^@ Similarity ^@ Belongs to the nanos family. http://togogenome.org/gene/9541:KLRF1 ^@ http://purl.uniprot.org/uniprot/Q8MI05 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Homodimer.|||Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts.|||Membrane http://togogenome.org/gene/9541:RPS26 ^@ http://purl.uniprot.org/uniprot/P61251 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS26 family.|||Component of the 40S small ribosomal subunit.|||Cytoplasm|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/9541:BMP10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNW7 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9541:PTPRD ^@ http://purl.uniprot.org/uniprot/A0A2K5V162|||http://purl.uniprot.org/uniprot/A0A2K5V168|||http://purl.uniprot.org/uniprot/A0A2K5V177 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. http://togogenome.org/gene/9541:FAM187B ^@ http://purl.uniprot.org/uniprot/G7PX85|||http://purl.uniprot.org/uniprot/Q4R7Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM187 family.|||Membrane http://togogenome.org/gene/9541:SNTA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||Cell junction|||cytoskeleton http://togogenome.org/gene/9541:IRX5 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/9541:PPP4R3C ^@ http://purl.uniprot.org/uniprot/G7Q2E9 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9541:PALMD ^@ http://purl.uniprot.org/uniprot/A0A2K5U7C7 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/9541:WDR4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQX8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat TRM82 family.|||Forms a heterodimer with the catalytic subunit METTL1.|||Nucleus|||Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. http://togogenome.org/gene/9541:CLTCL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2Z5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin heavy chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||Membrane|||coated pit http://togogenome.org/gene/9541:APOBEC3D ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ28 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:SLC35D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJZ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NFXL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYX8 ^@ Similarity ^@ Belongs to the NFX1 family. http://togogenome.org/gene/9541:SLCO1C1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0W0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:GET4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U286 ^@ Similarity ^@ Belongs to the GET4 family. http://togogenome.org/gene/9541:MIS18A ^@ http://purl.uniprot.org/uniprot/A0A2K5X5E4 ^@ Function|||Subcellular Location Annotation ^@ Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.|||centromere http://togogenome.org/gene/9541:ZNF575 ^@ http://purl.uniprot.org/uniprot/Q9GM03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:GPC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan that bears heparan sulfate. http://togogenome.org/gene/9541:MYO5B ^@ http://purl.uniprot.org/uniprot/A0A2K5UF09|||http://purl.uniprot.org/uniprot/A0A2K5UF50 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:NDUFV2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2C7|||http://purl.uniprot.org/uniprot/G7PWD9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. http://togogenome.org/gene/9541:DNMT3L ^@ http://purl.uniprot.org/uniprot/A0A2K5WRV1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ADCY2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TV06 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9541:CD163L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDF9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:MSX2 ^@ http://purl.uniprot.org/uniprot/A0A7N9D9E7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC101925844 ^@ http://purl.uniprot.org/uniprot/Q4R4B1 ^@ Similarity ^@ Belongs to the STEEP1 family. http://togogenome.org/gene/9541:NMNAT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VI95|||http://purl.uniprot.org/uniprot/G7NXG5 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9541:LOC102131775 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHK5 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9541:ZDHHC20 ^@ http://purl.uniprot.org/uniprot/A0A2K5VY00|||http://purl.uniprot.org/uniprot/A0A7N9IEJ6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:C6H5orf63 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEI7 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/9541:TMEM131 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWU9 ^@ Similarity ^@ Belongs to the TMEM131 family. http://togogenome.org/gene/9541:DDX5 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULU9|||http://purl.uniprot.org/uniprot/Q4R6G0|||http://purl.uniprot.org/uniprot/Q4R6M5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.|||Cytoplasm|||Identified in the spliceosome C complex. Component of a ribonucleoprotein complex containing mRNAs and RNA-binding proteins including DDX5, HNRNPH2 and SRSF1 as well as splicing regulator ARVCF. Interacts with RBM4; the interaction occurs in an RNA-independent manner. Interacts with AGO1 and AGO2. Interacts with ESR1, AR, EP300, CREBBP, POLR2A, TP53, RUNX2 and HDAC1. Self-associates. Interacts with DDX17. Interacts with BRDT. The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A (active) (By similarity). Interacts with DHX36; this interaction occurs in a RNA-dependent manner (By similarity). Interacts with NUPR1 (By similarity). Interacts with ERCC6 (By similarity). Interacts with DDX3X in the cytoplasm; this interaction may be more efficient when both proteins are unphosphorylated (By similarity).|||Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity).|||Nucleus|||Polyubiquitinated, leading to proteasomal degradation.|||Sumoylated; sumoylation, promoted by PIAS1, promotes interaction with HDAC1 and transcriptional repression activity. Sumoylation also significantly increases stability, and reduces polyubiquitination (By similarity).|||Weakly phosphorylated in the G1/S phase of the cell cycle and much more at G2/M, especially at Thr and Tyr residues.|||nucleolus http://togogenome.org/gene/9541:METTL6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8T9|||http://purl.uniprot.org/uniprot/A0A2K5X8U1|||http://purl.uniprot.org/uniprot/G7NY10 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9541:FASTKD5 ^@ http://purl.uniprot.org/uniprot/Q95KD0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FAST kinase family.|||Found in a complex with GRSF1, DDX28, DHX30 and FASTKD2. Associates with the 12S mitochondrial rRNA (12S mt-rRNA).|||Plays an important role in the processing of non-canonical mitochondrial mRNA precursors.|||mitochondrion nucleoid http://togogenome.org/gene/9541:NDUFS8 ^@ http://purl.uniprot.org/uniprot/A0A2K5U661|||http://purl.uniprot.org/uniprot/G7PP61|||http://purl.uniprot.org/uniprot/Q60HE3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 23 kDa subunit family.|||Binds 2 [4Fe-4S] cluster.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity). Interacts with RAB5IF (By similarity).|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for the catalytic activity and assembly of complex I (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/9541:KCNJ6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5N4|||http://purl.uniprot.org/uniprot/A0A8J8XP04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.|||Membrane http://togogenome.org/gene/9541:CACNG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFY4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. http://togogenome.org/gene/9541:SRP54 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y7F2|||http://purl.uniprot.org/uniprot/G7PA28|||http://purl.uniprot.org/uniprot/Q4R965 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity). Interacts with RNPS1 (By similarity). Interacts with the SRP receptor subunit SRPRA (By similarity).|||Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (By similarity). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (By similarity). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (By similarity). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (By similarity).|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.|||Cytoplasm|||Endoplasmic reticulum|||Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.|||Nucleus speckle|||The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.|||The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA (By similarity). The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another (By similarity). SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity). http://togogenome.org/gene/9541:P2RY13 ^@ http://purl.uniprot.org/uniprot/A0A2K5VG19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PABIR1 ^@ http://purl.uniprot.org/uniprot/Q4R310 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/9541:GLIS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLI C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9541:BARHL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9K6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:DHRS7B ^@ http://purl.uniprot.org/uniprot/A0A2K5UL93 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:MACF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPC0|||http://purl.uniprot.org/uniprot/A0A2K5TPC5 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:GJA4 ^@ http://purl.uniprot.org/uniprot/G7NTG4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9541:WDR46 ^@ http://purl.uniprot.org/uniprot/I7G7K9 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9541:IL36G ^@ http://purl.uniprot.org/uniprot/A0A2K5VYV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9541:PLAUR ^@ http://purl.uniprot.org/uniprot/A0A2K5VKK1|||http://purl.uniprot.org/uniprot/A0A7N9CJE3|||http://purl.uniprot.org/uniprot/Q9GK78 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form (By similarity).|||Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.|||Cell membrane|||Membrane|||Monomer (Probable). Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with MRC2. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane. Interacts with SORL1 (via N-terminal ectodomain); this interaction decreases PLAUR internalization (By similarity). The ternary complex composed of PLAUR-PLAU-SERPINE1 also interacts with SORL1 (By similarity).|||invadopodium membrane http://togogenome.org/gene/9541:GAA ^@ http://purl.uniprot.org/uniprot/A0A2K5VE94 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 31 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PSMF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U130|||http://purl.uniprot.org/uniprot/A0A7N9CTK2|||http://purl.uniprot.org/uniprot/Q4R934 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the proteasome inhibitor PI31 family.|||Cytoplasm|||Endoplasmic reticulum|||Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. http://togogenome.org/gene/9541:HENMT1 ^@ http://purl.uniprot.org/uniprot/Q4R3W5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. HEN1 family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis. http://togogenome.org/gene/9541:TMEM94 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9P4|||http://purl.uniprot.org/uniprot/A0A2K5W9S0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PSD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVK4|||http://purl.uniprot.org/uniprot/A0A2K5TVK8|||http://purl.uniprot.org/uniprot/A0A2K5TVL1 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/9541:PPP1R12B ^@ http://purl.uniprot.org/uniprot/A0A2K5WC23 ^@ Subcellular Location Annotation|||Subunit ^@ PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.|||stress fiber http://togogenome.org/gene/9541:TNFRSF11B ^@ http://purl.uniprot.org/uniprot/A0A2K5W5R9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:CLDN18 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVB4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:NMUR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/9541:TAC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V914|||http://purl.uniprot.org/uniprot/A0A7N9CCQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted http://togogenome.org/gene/9541:CHRNA5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:NUP205 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJ83|||http://purl.uniprot.org/uniprot/A0A2K5WJA6 ^@ Similarity ^@ Belongs to the NUP186/NUP192/NUP205 family. http://togogenome.org/gene/9541:STX1B ^@ http://purl.uniprot.org/uniprot/A0A2K5V277 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Membrane http://togogenome.org/gene/9541:RHOXF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2Q9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CPNE4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UX78|||http://purl.uniprot.org/uniprot/A0A2K5UX88|||http://purl.uniprot.org/uniprot/G7NXZ8 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9541:ALDH6A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X140 ^@ Function|||Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. http://togogenome.org/gene/9541:RGR ^@ http://purl.uniprot.org/uniprot/A0A2K5VGZ6|||http://purl.uniprot.org/uniprot/A0A7N9CQU1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:C4H6orf120 ^@ http://purl.uniprot.org/uniprot/Q9BGQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0669 family.|||May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.|||Secreted http://togogenome.org/gene/9541:NPFFR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W108 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9541:SLC39A10 ^@ http://purl.uniprot.org/uniprot/G7PL28 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:IDH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJA5 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/9541:SKA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPD1 ^@ Similarity ^@ Belongs to the SKA1 family. http://togogenome.org/gene/9541:NHP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XS32|||http://purl.uniprot.org/uniprot/G7P715 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/9541:PLK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U903 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/9541:COMTD1 ^@ http://purl.uniprot.org/uniprot/I7GHH8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/9541:CCL7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:EHD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3A9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane|||Recycling endosome membrane|||cilium membrane http://togogenome.org/gene/9541:ZDHHC15 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVP5|||http://purl.uniprot.org/uniprot/A0A8J8XFW1|||http://purl.uniprot.org/uniprot/G7Q328 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:CUL4B ^@ http://purl.uniprot.org/uniprot/A0A2K5W089|||http://purl.uniprot.org/uniprot/A0A2K5W092|||http://purl.uniprot.org/uniprot/G7Q3L8 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9541:JAKMIP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCL5|||http://purl.uniprot.org/uniprot/G7P582 ^@ Similarity ^@ Belongs to the JAKMIP family. http://togogenome.org/gene/9541:ASIC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UB59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/9541:CLDN17 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHT6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:MRPL28 ^@ http://purl.uniprot.org/uniprot/A0A2K5UD28 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/9541:ADGRF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIP9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PMPCB ^@ http://purl.uniprot.org/uniprot/A0A2K5TSZ1|||http://purl.uniprot.org/uniprot/Q4R5D5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M16 family.|||Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.|||Mitochondrion matrix http://togogenome.org/gene/9541:CSNK2B ^@ http://purl.uniprot.org/uniprot/G7P4Q2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the casein kinase 2 subunit beta family.|||Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/9541:LOC101865922 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0B2|||http://purl.uniprot.org/uniprot/I7GLL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/9541:PLSCR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJS8 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9541:CHAF1B ^@ http://purl.uniprot.org/uniprot/A0A2K5TRB7|||http://purl.uniprot.org/uniprot/A0A8J8Y6S7|||http://purl.uniprot.org/uniprot/G7P111 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ZNF446 ^@ http://purl.uniprot.org/uniprot/A0A2K5UI12 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:GPR52 ^@ http://purl.uniprot.org/uniprot/G8F2R8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:PAPSS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWP8|||http://purl.uniprot.org/uniprot/A0A2K5WWR5 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/9541:SYK ^@ http://purl.uniprot.org/uniprot/A0A2K5V790|||http://purl.uniprot.org/uniprot/A0A2K5V796|||http://purl.uniprot.org/uniprot/G7PSP1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. http://togogenome.org/gene/9541:LOC102133669 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2E6 ^@ Similarity ^@ Belongs to the histone H2B family. http://togogenome.org/gene/9541:SLC44A5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLA9|||http://purl.uniprot.org/uniprot/Q95JW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/9541:LANCL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WM40 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/9541:NRXN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVJ1|||http://purl.uniprot.org/uniprot/A0A2K5UVK9|||http://purl.uniprot.org/uniprot/A0A2K5UVT7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:LOC102132704 ^@ http://purl.uniprot.org/uniprot/A0A7N9CS21 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9541:MLC1 ^@ http://purl.uniprot.org/uniprot/Q60HE7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Endoplasmic reticulum|||Interacts with ATP1B1. Part of a complex containing ATP1B1, TRPV4, AQP4 and HEPACAM.|||Membrane|||Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx.|||perinuclear region http://togogenome.org/gene/9541:FXYD5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XKS7|||http://purl.uniprot.org/uniprot/G7PX84 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/9541:RRS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TP91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRS1 family.|||Involved in ribosomal large subunit assembly.|||Nucleus http://togogenome.org/gene/9541:SYNE3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTY2 ^@ Similarity ^@ Belongs to the nesprin family. http://togogenome.org/gene/9541:TALDO1 ^@ http://purl.uniprot.org/uniprot/I7G9S0 ^@ Function|||Similarity ^@ Belongs to the transaldolase family. Type 1 subfamily.|||Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate. http://togogenome.org/gene/9541:CCND3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJJ8|||http://purl.uniprot.org/uniprot/A0A7N9IGC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin D subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:GSTM4 ^@ http://purl.uniprot.org/uniprot/A0A023JCM9 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Mu family.|||Homodimer. http://togogenome.org/gene/9541:GABRA4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XR95|||http://purl.uniprot.org/uniprot/G7P5I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:PGC ^@ http://purl.uniprot.org/uniprot/A0A2K5U1R3|||http://purl.uniprot.org/uniprot/A0A8J8Y3M3|||http://purl.uniprot.org/uniprot/G7P3W6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Hydrolyzes a variety of proteins.|||Secreted http://togogenome.org/gene/9541:PDSS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1G8 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9541:SLC17A9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMG7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SULT4A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIR6 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9541:S100G ^@ http://purl.uniprot.org/uniprot/A0A2K5V3E4 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9541:DTX3L ^@ http://purl.uniprot.org/uniprot/A0A2K5UTM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/9541:ATP6V0E1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJT8|||http://purl.uniprot.org/uniprot/G7P6X2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9541:SENP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUE6 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9541:SEC22B ^@ http://purl.uniprot.org/uniprot/A0A8J8XBA0|||http://purl.uniprot.org/uniprot/G7NX73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Melanosome|||Membrane|||SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:ZC3H15 ^@ http://purl.uniprot.org/uniprot/I7GK97 ^@ Similarity ^@ Belongs to the ZC3H15/TMA46 family. http://togogenome.org/gene/9541:TMEM132D ^@ http://purl.uniprot.org/uniprot/A0A2K5TUJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM132 family.|||Membrane http://togogenome.org/gene/9541:CYP19A1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YF18|||http://purl.uniprot.org/uniprot/Q95LY0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:LOC102116612 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUV0 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9541:RNASE12 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIR3 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9541:DHRS3 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y406|||http://purl.uniprot.org/uniprot/G7NU67 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:UBA5 ^@ http://purl.uniprot.org/uniprot/A0A7N9CUJ7|||http://purl.uniprot.org/uniprot/Q4R920 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.|||Endoplasmic reticulum membrane|||Golgi apparatus http://togogenome.org/gene/9541:KEG98_p03 ^@ http://purl.uniprot.org/uniprot/C3W4Z5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 5 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:LOC102123184 ^@ http://purl.uniprot.org/uniprot/G7P9M6 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9541:FAM167B ^@ http://purl.uniprot.org/uniprot/A0A2K5TR07 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/9541:LOC102116629 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRG3|||http://purl.uniprot.org/uniprot/A0A8J8XC80|||http://purl.uniprot.org/uniprot/G7PUS6 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/9541:DOK5 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0K2 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9541:SDHB ^@ http://purl.uniprot.org/uniprot/G7NUQ9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/9541:S1PR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UC89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9541:PTPN12 ^@ http://purl.uniprot.org/uniprot/A0A2K5USI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.|||Cytoplasm|||Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. http://togogenome.org/gene/9541:SPPL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4Z3|||http://purl.uniprot.org/uniprot/A0A2K5W529 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/9541:NR1H3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9541:SIX6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SIX/Sine oculis homeobox family.|||Nucleus http://togogenome.org/gene/9541:DGKA ^@ http://purl.uniprot.org/uniprot/A0A8J8XJW0|||http://purl.uniprot.org/uniprot/G7PIF8 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9541:MPP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL68 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9541:PPP1R9A ^@ http://purl.uniprot.org/uniprot/A0A2K5WG75|||http://purl.uniprot.org/uniprot/A0A2K5WG76|||http://purl.uniprot.org/uniprot/A0A2K5WGF1|||http://purl.uniprot.org/uniprot/A0A2K5WGF7 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:TCF7L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/9541:RNF141 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWB7|||http://purl.uniprot.org/uniprot/G7PQQ9 ^@ Function ^@ May be involved in spermatogenesis. http://togogenome.org/gene/9541:ATG13 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRZ8|||http://purl.uniprot.org/uniprot/A0A2K5TS06|||http://purl.uniprot.org/uniprot/A0A2K5TS08|||http://purl.uniprot.org/uniprot/A0A2K5TS10|||http://purl.uniprot.org/uniprot/A0A7N9I9D3|||http://purl.uniprot.org/uniprot/G7PQB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.|||Belongs to the ATG13 family. Metazoan subfamily.|||Preautophagosomal structure http://togogenome.org/gene/9541:RAD23A ^@ http://purl.uniprot.org/uniprot/A0A2K5W9Q8|||http://purl.uniprot.org/uniprot/A0A2K5W9S8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/9541:HDAC8 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8N2 ^@ Similarity ^@ Belongs to the histone deacetylase family. HD type 1 subfamily. http://togogenome.org/gene/9541:SFXN5 ^@ http://purl.uniprot.org/uniprot/G7PMH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9541:GAR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ98 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GAR1 family.|||Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.|||nucleolus http://togogenome.org/gene/9541:HPGD ^@ http://purl.uniprot.org/uniprot/I7GNJ1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:L3MBTL4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VX15 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:GALNT14 ^@ http://purl.uniprot.org/uniprot/A0A7N9C9A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:FOXN2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YI45|||http://purl.uniprot.org/uniprot/G7PM65 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:USP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VG76 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9541:SLCO2B1 ^@ http://purl.uniprot.org/uniprot/L7T9F2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PIK3R1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CL43|||http://purl.uniprot.org/uniprot/A0A7N9CVN4 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/9541:ADGRL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4I3|||http://purl.uniprot.org/uniprot/A0A2K5X4I5|||http://purl.uniprot.org/uniprot/A0A2K5X4J3|||http://purl.uniprot.org/uniprot/A0A2K5X4Q5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SAP130 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1V3|||http://purl.uniprot.org/uniprot/A0A2K5U1X4|||http://purl.uniprot.org/uniprot/A0A2K5U218 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAP130 family.|||Nucleus http://togogenome.org/gene/9541:FAM126A ^@ http://purl.uniprot.org/uniprot/A0A2K5ULI0|||http://purl.uniprot.org/uniprot/A0A2K5ULI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM126 family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9541:MFAP3 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y105|||http://purl.uniprot.org/uniprot/G7P8R9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:SLC7A5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWN5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:THBS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V619 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ITIH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U480 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9541:TBX5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPI4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:PPP1CB ^@ http://purl.uniprot.org/uniprot/A0A2K5VEA0|||http://purl.uniprot.org/uniprot/A0A7N9CGK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||Cytoplasm|||nucleolus|||nucleoplasm http://togogenome.org/gene/9541:ITPA ^@ http://purl.uniprot.org/uniprot/A0A2K5X2C2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||Homodimer.|||Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. http://togogenome.org/gene/9541:C14H11orf1 ^@ http://purl.uniprot.org/uniprot/Q4R5Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0686 family.|||Nucleus http://togogenome.org/gene/9541:PDCL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7V0 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9541:GLRX ^@ http://purl.uniprot.org/uniprot/Q25N99 ^@ Function ^@ Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. http://togogenome.org/gene/9541:MRPS25 ^@ http://purl.uniprot.org/uniprot/A0A8J8XC86|||http://purl.uniprot.org/uniprot/G7PIM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS25 family.|||Mitochondrion http://togogenome.org/gene/9541:GPR18 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFM2|||http://purl.uniprot.org/uniprot/Q4R613 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Receptor for endocannabinoid N-arachidonyl glycine (NAGly). However, conflicting results about the role of NAGly as an agonist are reported. Can also be activated by plant-derived and synthetic cannabinoid agonists. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant. Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure. Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis. http://togogenome.org/gene/9541:C15H9orf78 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWM3|||http://purl.uniprot.org/uniprot/G7PRD0 ^@ Similarity ^@ Belongs to the TLS1 family. http://togogenome.org/gene/9541:SARAF ^@ http://purl.uniprot.org/uniprot/I7GEM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SARAF family.|||Endoplasmic reticulum membrane|||Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.|||Membrane|||Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. http://togogenome.org/gene/9541:MYO18B ^@ http://purl.uniprot.org/uniprot/A0A2K5TZC8 ^@ Caution|||Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:OTOP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VR41|||http://purl.uniprot.org/uniprot/G7PVC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:UBLCP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XGL9|||http://purl.uniprot.org/uniprot/G7P6S1 ^@ Function|||Subcellular Location Annotation ^@ Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.|||Nucleus http://togogenome.org/gene/9541:ECHDC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN28|||http://purl.uniprot.org/uniprot/A0A2K5UN41 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9541:SNAP23 ^@ http://purl.uniprot.org/uniprot/G7PB04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||synaptosome http://togogenome.org/gene/9541:LOC102132956 ^@ http://purl.uniprot.org/uniprot/A0A2K5UF57 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/9541:GPR55 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZW1|||http://purl.uniprot.org/uniprot/G7PK96 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:GJC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with CNST.|||Belongs to the connexin family. Gamma-type subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9541:ZCCHC17 ^@ http://purl.uniprot.org/uniprot/I7G7J6|||http://purl.uniprot.org/uniprot/I7GK89|||http://purl.uniprot.org/uniprot/Q95KF9 ^@ Subcellular Location Annotation|||Subunit ^@ May interact with PNN. May associate with the 60 S ribosomal subunit (By similarity).|||nucleolus http://togogenome.org/gene/9541:GFRA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWP3|||http://purl.uniprot.org/uniprot/A0A2K5TWP5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.|||Belongs to the GDNFR family.|||Cell membrane|||Membrane|||Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. http://togogenome.org/gene/9541:NPC1L1 ^@ http://purl.uniprot.org/uniprot/A0MJA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/9541:RIMKLB ^@ http://purl.uniprot.org/uniprot/A0A2K5X5J2 ^@ Similarity ^@ Belongs to the RimK family. http://togogenome.org/gene/9541:LACTB2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XH33|||http://purl.uniprot.org/uniprot/G7PC06 ^@ Function|||Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability. http://togogenome.org/gene/9541:COPS5 ^@ http://purl.uniprot.org/uniprot/A0A8J8YCP6|||http://purl.uniprot.org/uniprot/G7PBZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN5 subfamily.|||synaptic vesicle http://togogenome.org/gene/9541:TMEM229B ^@ http://purl.uniprot.org/uniprot/A0A2K5UEI4|||http://purl.uniprot.org/uniprot/A0A7N9D440 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM229 family.|||Membrane http://togogenome.org/gene/9541:LOC102145267 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEU2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:CDYL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXV8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:DSG3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXA4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||desmosome http://togogenome.org/gene/9541:CDH15 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ87 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PON1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQD9|||http://purl.uniprot.org/uniprot/G7P1C5 ^@ Cofactor|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit. http://togogenome.org/gene/9541:ATP6V0D2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V996 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9541:DYNC1I2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRP0|||http://purl.uniprot.org/uniprot/A0A2K5WRQ2 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/9541:SYNDIG1 ^@ http://purl.uniprot.org/uniprot/G7PH54|||http://purl.uniprot.org/uniprot/I7GHI6|||http://purl.uniprot.org/uniprot/Q4R532 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CD225/Dispanin family.|||Cell membrane|||Early endosome membrane|||Homodimer. Interacts with GRIA1 and GRIA2 (By similarity).|||May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation.|||Postsynaptic density membrane|||Synapse|||dendrite|||dendritic spine http://togogenome.org/gene/9541:RBPJL ^@ http://purl.uniprot.org/uniprot/A0A2K5WU64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Su(H) family.|||Nucleus http://togogenome.org/gene/9541:SLC12A5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2B4|||http://purl.uniprot.org/uniprot/A0A2K5U2D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9541:EPB42 ^@ http://purl.uniprot.org/uniprot/A0A2K5VE29 ^@ Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family. http://togogenome.org/gene/9541:RNF31 ^@ http://purl.uniprot.org/uniprot/A0A7N9CDH5|||http://purl.uniprot.org/uniprot/A0A8J8Y808|||http://purl.uniprot.org/uniprot/G7P9X8 ^@ Similarity ^@ Belongs to the RBR family. http://togogenome.org/gene/9541:GPR119 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTZ9|||http://purl.uniprot.org/uniprot/G7Q3P2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:KCNMB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U386|||http://purl.uniprot.org/uniprot/A0A2K5U398|||http://purl.uniprot.org/uniprot/A0A2K5U3A2 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9541:RAB33A ^@ http://purl.uniprot.org/uniprot/A0A8J8XQ87|||http://purl.uniprot.org/uniprot/G7Q3N9 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/9541:LOC102143706 ^@ http://purl.uniprot.org/uniprot/G7PRN4|||http://purl.uniprot.org/uniprot/I7G5H0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SOSS-C family.|||Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).|||Component of the SOSS complex.|||Nucleus http://togogenome.org/gene/9541:LAMA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4S5 ^@ Caution|||Function ^@ Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:TYR ^@ http://purl.uniprot.org/uniprot/A0A2K5VT29|||http://purl.uniprot.org/uniprot/G7PNE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/9541:CD4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YDH1|||http://purl.uniprot.org/uniprot/G7PJN3 ^@ Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Forms disulfide-linked homodimers at the cell surface. Interacts with LCK. Interacts with PTK2/FAK1. Binds to P4HB/PDI. Interacts with IL16; this interaction induces a CD4-dependent signaling in lymphocytes. Interacts (via Ig-like V-type domain) with MHCII alpha chain (via alpha-2 domain) and beta chain (via beta-2 domain); this interaction increases the affinity of TCR for peptide-MHCII. CD4 oligomerization via Ig-like C2-type 2 and 3 domains appears to be required for stable binding to MHCII and adhesion between T cells and APCs. http://togogenome.org/gene/9541:KMT5C ^@ http://purl.uniprot.org/uniprot/A0A2K5U5P8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TRAPPC2B ^@ http://purl.uniprot.org/uniprot/I7G790 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/9541:ALKBH6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W013 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9541:MMP9 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||extracellular matrix http://togogenome.org/gene/9541:ADD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVU2|||http://purl.uniprot.org/uniprot/A0A2K5UVU3|||http://purl.uniprot.org/uniprot/G7PDY1 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/9541:SPATS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPATS2 family.|||Cytoplasm http://togogenome.org/gene/9541:CAPZA3 ^@ http://purl.uniprot.org/uniprot/G7PJZ7|||http://purl.uniprot.org/uniprot/Q4R7M8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity).|||Heterodimer of an alpha and a beta subunit.|||Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5 (By similarity). http://togogenome.org/gene/9541:HSPB1 ^@ http://purl.uniprot.org/uniprot/I7GIP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus|||spindle http://togogenome.org/gene/9541:RER1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V184|||http://purl.uniprot.org/uniprot/G7NT94 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RER1 family.|||Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.|||Membrane http://togogenome.org/gene/9541:PLD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPG7|||http://purl.uniprot.org/uniprot/G7NWL7 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9541:LOC102120655 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJS7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9541:WNT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:SLC51A ^@ http://purl.uniprot.org/uniprot/A0A7N9DE93 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:FAM133B ^@ http://purl.uniprot.org/uniprot/A0A2K5WBD7 ^@ Similarity ^@ Belongs to the FAM133 family. http://togogenome.org/gene/9541:FBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V701 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/9541:LOC102144583 ^@ http://purl.uniprot.org/uniprot/A0A8J8YCN9|||http://purl.uniprot.org/uniprot/G7NTR6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:RPRD1B ^@ http://purl.uniprot.org/uniprot/A0A8J8YRX8|||http://purl.uniprot.org/uniprot/G7PGE9 ^@ Function|||Similarity|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. http://togogenome.org/gene/9541:ITM2C ^@ http://purl.uniprot.org/uniprot/Q25PJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/9541:ERO1A ^@ http://purl.uniprot.org/uniprot/A0A2K5UA33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:HSPB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/9541:SLC37A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYE4|||http://purl.uniprot.org/uniprot/A0A2K5TYF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.|||Membrane http://togogenome.org/gene/9541:TBK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYJ5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:SFN ^@ http://purl.uniprot.org/uniprot/A0A2K5UH26 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9541:INPPL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJT9 ^@ Subcellular Location Annotation ^@ Basal cell membrane|||spindle pole http://togogenome.org/gene/9541:LUC7L ^@ http://purl.uniprot.org/uniprot/A0A2K5WBM3|||http://purl.uniprot.org/uniprot/A0A2K5WBP6 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9541:LOC102117144 ^@ http://purl.uniprot.org/uniprot/G7P2Q3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:CAPN10 ^@ http://purl.uniprot.org/uniprot/Q95LP4 ^@ Function|||Similarity ^@ Belongs to the peptidase C2 family.|||Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake (By similarity). http://togogenome.org/gene/9541:KRT8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TS68|||http://purl.uniprot.org/uniprot/A0A7N9CB91 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:MPP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WE78 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9541:ABCC9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ71|||http://purl.uniprot.org/uniprot/A0A2K5VZC3|||http://purl.uniprot.org/uniprot/A0A2K5VZD7 ^@ Subunit ^@ Interacts with KCNJ11. http://togogenome.org/gene/9541:LOC102126833 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQJ1|||http://purl.uniprot.org/uniprot/I7GL91 ^@ Subcellular Location Annotation ^@ Membrane|||chromaffin granule membrane http://togogenome.org/gene/9541:GTF2A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKH3|||http://purl.uniprot.org/uniprot/A0A2K5TKH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Stoned B family.|||Belongs to the TFIIA subunit 1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:CRHR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRX5|||http://purl.uniprot.org/uniprot/A0A2K5WS31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Membrane http://togogenome.org/gene/9541:LYRM4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXT9|||http://purl.uniprot.org/uniprot/A0A7N9CNF5 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9541:LOC102120909 ^@ http://purl.uniprot.org/uniprot/Q4W8A3 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Cell membrane|||Expressed in kidney; in the basolateral membrane of the proximal tubule.|||Glycosylated. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane (By similarity).|||Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion (By similarity). Also mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP), chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), and edaravone sulfate (By similarity). Mediates the sodium-independent uptake of p-aminohippurate (PAH), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), cimetidine (CMD), indoxyl sulfate (IS), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF). PAH uptake is inhibited by furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), diclofenac, carprofen, sulindac, calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, okadaic acid, benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), glutarate and alpha-ketoglutarate (By similarity).|||Multiple cysteine residues are necessary for proper targeting to the plasma membrane. http://togogenome.org/gene/9541:MED28 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 28 family.|||Nucleus http://togogenome.org/gene/9541:ATP6V1C1 ^@ http://purl.uniprot.org/uniprot/G7PCG4|||http://purl.uniprot.org/uniprot/Q4R5H9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity).|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity).|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.|||clathrin-coated vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/9541:PTCD2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CFC3|||http://purl.uniprot.org/uniprot/I7GIK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTCD2 family.|||Mitochondrion http://togogenome.org/gene/9541:LAMTOR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJG8|||http://purl.uniprot.org/uniprot/G7PR11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the APC15 family.|||Belongs to the LAMTOR1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9541:LOC102138671 ^@ http://purl.uniprot.org/uniprot/I7GJ70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Cytoplasm|||Homotrimer.|||Nucleus http://togogenome.org/gene/9541:TNP2 ^@ http://purl.uniprot.org/uniprot/Q8WNV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the nuclear transition protein 2 family.|||Chromosome|||Nucleus|||Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.|||Testis.|||nucleolus http://togogenome.org/gene/9541:GTF2A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. http://togogenome.org/gene/9541:TRMT6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZJ3|||http://purl.uniprot.org/uniprot/G7PGX6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM6/GCD10 family.|||Heterotetramer.|||Nucleus|||Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. http://togogenome.org/gene/9541:PNRC1 ^@ http://purl.uniprot.org/uniprot/Q4R4L2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:DNAL4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9541:AKIRIN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/9541:PEDS1 ^@ http://purl.uniprot.org/uniprot/I7GNR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase CarF family.|||Membrane http://togogenome.org/gene/9541:ACTA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1C8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:POMC ^@ http://purl.uniprot.org/uniprot/A0A2K5X883 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.|||Belongs to the POMC family.|||Endogenous opiate.|||Endogenous orexigenic opiate.|||Secreted|||Stimulates the adrenal glands to release cortisol. http://togogenome.org/gene/9541:NLRP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WM90 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/9541:PHC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UF17|||http://purl.uniprot.org/uniprot/G7PJR2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:RPS3A ^@ http://purl.uniprot.org/uniprot/Q4R4Z6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ADP-ribosylated at Tyr-155 by PARP1 in presence of HPF1.|||Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.|||Cytoplasm|||May play a role during erythropoiesis through regulation of transcription factor DDIT3.|||Nucleus http://togogenome.org/gene/9541:PROKR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9541:RTF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYR6 ^@ Similarity|||Subunit ^@ Belongs to the rtf2 family.|||Interacts with DDI2; probably also interacts with DDI1. http://togogenome.org/gene/9541:CD34 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCU4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CUL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRW3|||http://purl.uniprot.org/uniprot/A0A7N9CNI7 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9541:MPP7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQA8|||http://purl.uniprot.org/uniprot/G7PEN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||adherens junction|||tight junction http://togogenome.org/gene/9541:SSR2 ^@ http://purl.uniprot.org/uniprot/G7NV73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-beta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9541:EDEM3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1I7|||http://purl.uniprot.org/uniprot/A0A2K5V1K9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9541:SPACA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVB4|||http://purl.uniprot.org/uniprot/A0A2K5TVB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 22 family.|||Interacts with ASTL.|||Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.|||acrosome membrane http://togogenome.org/gene/9541:GPAM ^@ http://purl.uniprot.org/uniprot/A0A2K5V1Q6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.|||Mitochondrion outer membrane http://togogenome.org/gene/9541:RAD18 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD18 family.|||Nucleus http://togogenome.org/gene/9541:GRHPR ^@ http://purl.uniprot.org/uniprot/A0A2K5V7Q6|||http://purl.uniprot.org/uniprot/A0A2K5V7S5 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/9541:GSTCD ^@ http://purl.uniprot.org/uniprot/A0A2K5X8G8|||http://purl.uniprot.org/uniprot/Q4R6Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSTCD family.|||Cytoplasm http://togogenome.org/gene/9541:CKS1B ^@ http://purl.uniprot.org/uniprot/A0A7N9DBP2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/9541:TMEM168 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIL0|||http://purl.uniprot.org/uniprot/A0A8J8XBZ6|||http://purl.uniprot.org/uniprot/G7P2H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM168 family.|||Membrane http://togogenome.org/gene/9541:SLC25A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:SERPINB5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family. Ov-serpin subfamily.|||extracellular space http://togogenome.org/gene/9541:EIF1AD ^@ http://purl.uniprot.org/uniprot/Q4R354 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EIF1AD family.|||Interacts with GAPDH and STAT1.|||Nucleus|||Plays a role into cellular response to oxidative stress. Decreases cell proliferation (By similarity). http://togogenome.org/gene/9541:CFB ^@ http://purl.uniprot.org/uniprot/A0A2K5TZY3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:CTSD ^@ http://purl.uniprot.org/uniprot/I7G2Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Lysosome|||extracellular space http://togogenome.org/gene/9541:ARG2 ^@ http://purl.uniprot.org/uniprot/I7GPI4 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9541:MYOD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3Q3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CIT ^@ http://purl.uniprot.org/uniprot/A0A2K5U1S5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||Plays a role in cytokinesis. Displays serine/threonine protein kinase activity. http://togogenome.org/gene/9541:ELAC2 ^@ http://purl.uniprot.org/uniprot/Q8HY87 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase Z family.|||Homodimer. Interacts with PTCD1.|||Mitochondrion|||Nucleus|||Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.|||mitochondrion nucleoid http://togogenome.org/gene/9541:NCAPH ^@ http://purl.uniprot.org/uniprot/Q4R332 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CND2 (condensin subunit 2) family.|||Chromosome|||Cytoplasm|||Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. http://togogenome.org/gene/9541:MFSD14B ^@ http://purl.uniprot.org/uniprot/A0A2K5VC27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9541:GLIPR1L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUU6 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/9541:MCTP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJI3|||http://purl.uniprot.org/uniprot/G7P9I2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102136728 ^@ http://purl.uniprot.org/uniprot/A0A2K5TN42 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9541:TAF7 ^@ http://purl.uniprot.org/uniprot/G7P8I3|||http://purl.uniprot.org/uniprot/Q4R5A5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TAF7 family.|||Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Interacts with TAF1; the interaction is direct. Interacts with TAF1, TAF5, TAF11, TAF12, and TAF13, but not with TAF10 or TBP. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CIITA and TAF1 and inhibits their acetyltransferase activity, and behaving as a repressor of CIITA- and TAF1-regulated promoters.|||Nucleus|||Phosphorylated by CIITA. Phosphorylation at Ser-264 by TAF1 in early G1 phase disrupts binding to TAF1.|||The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2. Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta). http://togogenome.org/gene/9541:KRT35 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7X7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:CFAP36 ^@ http://purl.uniprot.org/uniprot/I7GAR5 ^@ Similarity ^@ Belongs to the CFAP36 family. http://togogenome.org/gene/9541:ATXN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X800 ^@ Similarity ^@ Belongs to the ataxin-2 family. http://togogenome.org/gene/9541:CEP63 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQF1|||http://purl.uniprot.org/uniprot/A0A2K5TQF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP63 family.|||centriolar satellite http://togogenome.org/gene/9541:LOC102138406 ^@ http://purl.uniprot.org/uniprot/G7P2Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:MINDY4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFI6 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/9541:SHROOM4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYG0|||http://purl.uniprot.org/uniprot/A0A2K5VYH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/9541:PPM1L ^@ http://purl.uniprot.org/uniprot/A0A8J8YJJ4|||http://purl.uniprot.org/uniprot/G7NZI0 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9541:HOGA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8D4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the final step in the metabolic pathway of hydroxyproline.|||Homotetramer. http://togogenome.org/gene/9541:REV1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGG2|||http://purl.uniprot.org/uniprot/A0A2K5VGG8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-Y family.|||Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.|||Nucleus http://togogenome.org/gene/9541:TMEM255A ^@ http://purl.uniprot.org/uniprot/A0A2K5TMD0|||http://purl.uniprot.org/uniprot/A0A2K5TMD5|||http://purl.uniprot.org/uniprot/Q9BE63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM255 family.|||Membrane http://togogenome.org/gene/9541:RANBP10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBP7 ^@ Similarity ^@ Belongs to the RANBP9/10 family. http://togogenome.org/gene/9541:EXOSC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/9541:FREM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0Q1|||http://purl.uniprot.org/uniprot/A0A2K5U0W9 ^@ Similarity ^@ Belongs to the FRAS1 family. http://togogenome.org/gene/9541:PDZK1IP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ39|||http://purl.uniprot.org/uniprot/G8F516 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:DESI2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2W7|||http://purl.uniprot.org/uniprot/G8F4C7 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/9541:ZNF383 ^@ http://purl.uniprot.org/uniprot/Q4R6C2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||Cytoplasm|||May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.|||Nucleus|||The KRAB domain is responsible for the transcriptional repressor activity. http://togogenome.org/gene/9541:PSMC2 ^@ http://purl.uniprot.org/uniprot/Q4R4R0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AAA ATPase family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC2 and few additional components. Interacts with NDC80/HEC; this interaction is detected only during M phase. Interacts and SQSTM1. Interacts with PAAF1. Directly interacts with TRIM5.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.|||Cytoplasm|||Monoubiquitinated by RNF181.|||Nucleus http://togogenome.org/gene/9541:SIN3B ^@ http://purl.uniprot.org/uniprot/A0A2K5U753|||http://purl.uniprot.org/uniprot/A0A2K5U768 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CLCN5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UX41|||http://purl.uniprot.org/uniprot/A0A2K5UXD4|||http://purl.uniprot.org/uniprot/G7Q2R0 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.|||Cell membrane|||Endosome membrane|||Golgi apparatus membrane|||Interacts with NEDD4 and NEDD4L.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:RIC8B ^@ http://purl.uniprot.org/uniprot/A0A2K5WDJ2|||http://purl.uniprot.org/uniprot/A0A2K5WDJ4|||http://purl.uniprot.org/uniprot/A0A2K5WDN4|||http://purl.uniprot.org/uniprot/A0A2K5WDN6|||http://purl.uniprot.org/uniprot/A0A2K5WDW8|||http://purl.uniprot.org/uniprot/A0A7N9CPF4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/9541:ACVR1C ^@ http://purl.uniprot.org/uniprot/A0A2K5VZI1|||http://purl.uniprot.org/uniprot/A0A2K5VZP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9541:ARL6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VB91|||http://purl.uniprot.org/uniprot/A0A8J8XKV2|||http://purl.uniprot.org/uniprot/G7NZ67|||http://purl.uniprot.org/uniprot/I7GKS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||cilium membrane http://togogenome.org/gene/9541:LOC102138968 ^@ http://purl.uniprot.org/uniprot/A0A2K5VE97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lambda interferon family.|||Secreted http://togogenome.org/gene/9541:LOC102147244 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystatin family.|||Secreted http://togogenome.org/gene/9541:KDSR ^@ http://purl.uniprot.org/uniprot/A0A7N9IDX9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:AKT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WA57 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/9541:WDR82 ^@ http://purl.uniprot.org/uniprot/A0A7N9CXF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SWD2 family.|||Nucleus http://togogenome.org/gene/9541:SCML4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X988 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ZMYND10 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6W9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the ZMYND10 family.|||Dynein axonemal particle|||Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.|||centriolar satellite http://togogenome.org/gene/9541:VPS41 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS41 family.|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.|||Vesicle|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/9541:DEF8 ^@ http://purl.uniprot.org/uniprot/I7G4B3 ^@ Similarity ^@ Belongs to the DEF8 family. http://togogenome.org/gene/9541:ICAM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WE44|||http://purl.uniprot.org/uniprot/G8F5R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/9541:POU3F4 ^@ http://purl.uniprot.org/uniprot/G7Q354 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-3 subfamily.|||Nucleus http://togogenome.org/gene/9541:LOC102120368 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN85 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:LDB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUY6|||http://purl.uniprot.org/uniprot/A0A2K5WV57|||http://purl.uniprot.org/uniprot/G7PDU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LDB family.|||Nucleus http://togogenome.org/gene/9541:CD3D ^@ http://purl.uniprot.org/uniprot/A0A2K5VUZ5|||http://purl.uniprot.org/uniprot/G7PP34|||http://purl.uniprot.org/uniprot/Q95LI8 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ CD3D is mostly present on T-lymphocytes with its TCR-CD3 partners. Present also in fetal NK-cells.|||Cell membrane|||Membrane|||Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells.|||Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.|||The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. Interacts with coreceptors CD4 and CD8. http://togogenome.org/gene/9541:OPN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9541:SMARCA5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VI90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.|||Nucleus http://togogenome.org/gene/9541:PGGT1B ^@ http://purl.uniprot.org/uniprot/A0A2K5WTH1|||http://purl.uniprot.org/uniprot/G7P826 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit beta family. http://togogenome.org/gene/9541:DNASE1L2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1N6 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9541:LOC102117187 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPR2|||http://purl.uniprot.org/uniprot/G7NTR4 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:XPO6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:PLOD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7U6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9541:EXOC3L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0H9 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/9541:LOC101925125 ^@ http://purl.uniprot.org/uniprot/A0A2K5VY38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin basic protein family.|||Myelin membrane http://togogenome.org/gene/9541:IGF2BP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6T2|||http://purl.uniprot.org/uniprot/A0A7N9CA49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||Nucleus|||P-body|||Stress granule http://togogenome.org/gene/9541:LOC102144656 ^@ http://purl.uniprot.org/uniprot/A0A2K5X814 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9541:ANO4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TK58|||http://purl.uniprot.org/uniprot/A0A2K5TK63 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:NDUFA5 ^@ http://purl.uniprot.org/uniprot/Q4R5J1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:RIPPLY2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ripply family.|||Nucleus http://togogenome.org/gene/9541:CRKL ^@ http://purl.uniprot.org/uniprot/A0A8J8YEB0|||http://purl.uniprot.org/uniprot/G7PHA6 ^@ Similarity ^@ Belongs to the CRK family. http://togogenome.org/gene/9541:ZNF75A ^@ http://purl.uniprot.org/uniprot/G7Q0C4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ADCK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAW9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/9541:NR0B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0Z8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus|||Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency. http://togogenome.org/gene/9541:MSH5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPJ3 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutS family. http://togogenome.org/gene/9541:ADAMTS13 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNC6 ^@ Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Secreted http://togogenome.org/gene/9541:LELP1 ^@ http://purl.uniprot.org/uniprot/Q4R956 ^@ Similarity ^@ Belongs to the cornifin (SPRR) family. http://togogenome.org/gene/9541:HOXD10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTS0|||http://purl.uniprot.org/uniprot/G7PKW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9541:CD36 ^@ http://purl.uniprot.org/uniprot/A0A8J8XGH3|||http://purl.uniprot.org/uniprot/Q4R6B4 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the CD36 family.|||Cell membrane|||Golgi apparatus|||Membrane|||Membrane raft http://togogenome.org/gene/9541:GTF2H2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6X1|||http://purl.uniprot.org/uniprot/G7P7P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Nucleus http://togogenome.org/gene/9541:AP3B2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1G5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes large subunit family.|||Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9541:TEN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WND5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:MAPK4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNV1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9541:ZNF687 ^@ http://purl.uniprot.org/uniprot/A0A2K5WG95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:PSMD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLI1 ^@ Similarity ^@ Belongs to the proteasome subunit S3 family. http://togogenome.org/gene/9541:F13A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7L6 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9541:CERS6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WS77|||http://purl.uniprot.org/uniprot/A0A7N9DG37|||http://purl.uniprot.org/uniprot/A0A8J8YJ84 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9541:PNMT ^@ http://purl.uniprot.org/uniprot/A0A2K5W5P1 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. http://togogenome.org/gene/9541:UROS ^@ http://purl.uniprot.org/uniprot/A0A2K5VG84|||http://purl.uniprot.org/uniprot/A0A7N9C9Y7|||http://purl.uniprot.org/uniprot/A0A7N9D060|||http://purl.uniprot.org/uniprot/A0A7N9D6H7 ^@ Similarity ^@ Belongs to the uroporphyrinogen-III synthase family. http://togogenome.org/gene/9541:LOC102121517 ^@ http://purl.uniprot.org/uniprot/G7P2L9|||http://purl.uniprot.org/uniprot/G7P2N0|||http://purl.uniprot.org/uniprot/Q4R362 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.|||Belongs to the histone H4 family.|||Butyrylation of histones marks active promoters and competes with histone acetylation.|||Chromosome|||Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).|||Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.|||Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.|||Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.|||Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).|||Nucleus|||Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).|||Sumoylated, which is associated with transcriptional repression.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).|||Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. http://togogenome.org/gene/9541:MRPS12 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQN7|||http://purl.uniprot.org/uniprot/G7PXI2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/9541:IP6K1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSG4 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9541:VPS33A ^@ http://purl.uniprot.org/uniprot/Q4R7U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||clathrin-coated vesicle http://togogenome.org/gene/9541:LOC102143000 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5C1|||http://purl.uniprot.org/uniprot/G7PMS9 ^@ Function|||Similarity ^@ Belongs to the PET191 family.|||Involved in an early step of the mitochondrial complex IV assembly process. http://togogenome.org/gene/9541:INTS9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VH01|||http://purl.uniprot.org/uniprot/Q4R5Z4 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although strongly related to RNA-specific endonuclease proteins, it lacks the HXHXDH motif that binds zinc and participates in the catalytic center. Its function as endonuclease is therefore unsure.|||Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.|||Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12 (By similarity). Interacts with ESRRB, ESRRB is probably not a core component of the multiprotein complex Integrator and this association is a bridge for the interaction with the multiprotein complex Integrator; attracts the transcriptional machinery (By similarity).|||Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.|||Nucleus http://togogenome.org/gene/9541:TMEM106C ^@ http://purl.uniprot.org/uniprot/A0A8J8XK76|||http://purl.uniprot.org/uniprot/G7PHP8 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9541:AGT ^@ http://purl.uniprot.org/uniprot/I7GH44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family.|||Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.|||Secreted|||Stimulates aldosterone release. http://togogenome.org/gene/9541:HOXB8 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8D3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ISM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3N4 ^@ Similarity ^@ Belongs to the isthmin family. http://togogenome.org/gene/9541:FAM241B ^@ http://purl.uniprot.org/uniprot/A0A2K5V1N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM241 family.|||Membrane http://togogenome.org/gene/9541:LOC102134569 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQZ0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/9541:PAFAH1B1 ^@ http://purl.uniprot.org/uniprot/Q8HXX0 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LIS1/nudF family.|||Can self-associate. Component of the cytosolic PAF-AH (I) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity. Interacts with the catalytic dimer of PAF-AH (I) heterotetrameric enzyme: interacts with PAFAH1B2 homodimer (alpha2/alpha2 homodimer), PAFAH1B3 homodimer (alpha1/alpha1 homodimer) and PAFAH1B2-PAFAH1B3 heterodimer (alpha2/alpha1 heterodimer) (By similarity). Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Interacts with INTS13. Interacts with DCDC1.|||Dimerization mediated by the LisH domain may be required to activate dynein.|||Nucleus membrane|||Originally the subunits of the type I platelet-activating factor (PAF) acetylhydrolase was named alpha (PAFAH1B1), beta (PAFAH1B2) and gamma (PAFAH1B3) (By similarity). Now these subunits have been renamed beta (PAFAH1B1), alpha2 (PAFAH1B2) and alpha1 (PAFAH1B3) respectively (By similarity).|||Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos. May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity).|||centrosome|||cytoskeleton|||spindle http://togogenome.org/gene/9541:LOC102146206 ^@ http://purl.uniprot.org/uniprot/Q9GKV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:KCNAB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0E9|||http://purl.uniprot.org/uniprot/A0A2K5V0F2|||http://purl.uniprot.org/uniprot/A0A2K5V0K6|||http://purl.uniprot.org/uniprot/I7GK52 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Cytoplasm|||Membrane|||Monomer. http://togogenome.org/gene/9541:LOC102134986 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFV7 ^@ Function|||Similarity ^@ Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis. http://togogenome.org/gene/9541:TAF8 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5F7|||http://purl.uniprot.org/uniprot/A0A7N9DFF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF8 family.|||Nucleus http://togogenome.org/gene/9541:MSRA ^@ http://purl.uniprot.org/uniprot/Q2PFZ6 ^@ Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family. http://togogenome.org/gene/9541:LIAS ^@ http://purl.uniprot.org/uniprot/A0A2K5WF34 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Mitochondrion http://togogenome.org/gene/9541:LOC102119459 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4A4|||http://purl.uniprot.org/uniprot/A0A2K5W4A5 ^@ Similarity ^@ Belongs to the liprin family. Liprin-beta subfamily. http://togogenome.org/gene/9541:BAZ2A ^@ http://purl.uniprot.org/uniprot/A0A2K5UPU3|||http://purl.uniprot.org/uniprot/A0A2K5UPV6|||http://purl.uniprot.org/uniprot/A0A2K5UQ15 ^@ Similarity ^@ Belongs to the WAL family. http://togogenome.org/gene/9541:WDR55 ^@ http://purl.uniprot.org/uniprot/A0A2K5U921 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR55 family.|||Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.|||nucleolus http://togogenome.org/gene/9541:CYP11A1 ^@ http://purl.uniprot.org/uniprot/Q2XV99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).|||Belongs to the cytochrome P450 family.|||Interacts with FDX1/adrenodoxin.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:CTSH ^@ http://purl.uniprot.org/uniprot/A0A2K5TRN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9541:ZBTB8OS ^@ http://purl.uniprot.org/uniprot/A0A2K5V6L5 ^@ Similarity|||Subunit ^@ Belongs to the archease family.|||Component of the tRNA-splicing ligase complex. http://togogenome.org/gene/9541:TUBA1B ^@ http://purl.uniprot.org/uniprot/Q25MB8|||http://purl.uniprot.org/uniprot/Q4R538 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.|||Belongs to the tubulin family.|||Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis: detyrosination promotes interaction with CENPE, promoting pole-proximal transport of chromosomes toward the equator (By similarity). Detyrosination increases microtubules-dependent mechanotransduction in dystrophic cardiac and skeletal muscle. In cardiomyocytes, detyrosinated microtubules are required to resist to contractile compression during contraction: detyrosination promotes association with desmin (DES) at force-generating sarcomeres, leading to buckled microtubules and mechanical resistance to contraction (By similarity).|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Nascent tubulin polypeptide interacts (via beta-tubulin MREC motif) with TTC5/STRAP; this interaction may result in tubulin mRNA-targeted degradation.|||Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.|||Nitration of Tyr-451 is irreversible and interferes with normal dynein intracellular distribution.|||Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (By similarity).|||Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility.|||The MREC motif mediates interaction with TTC5/STRAP and may be critical for tubulin autoregulation.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||Tyrosination promotes microtubule interaction with CAP-Gly domain-containing proteins such as CLIP1, CLIP2 and DCTN1 (By similarity). Tyrosination regulates the initiation of dynein-dynactin motility via interaction with DCTN1, which brings the dynein-dynactin complex into contact with microtubules. In neurons, tyrosinated tubulins mediate the initiation of retrograde vesicle transport (By similarity).|||Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (MATCAP, VASH1 or VASH2) and tubulin tyrosine ligase (TTL), respectively.|||cytoskeleton http://togogenome.org/gene/9541:EXOSC7 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTH2|||http://purl.uniprot.org/uniprot/G7NY47 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:SERPINB8 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7F4 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:NLGN4X ^@ http://purl.uniprot.org/uniprot/A0A2K5WKF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PDE11A ^@ http://purl.uniprot.org/uniprot/A0A8J8YBB3|||http://purl.uniprot.org/uniprot/G7PKX5 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:PYCR3 ^@ http://purl.uniprot.org/uniprot/I7GL29 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/9541:SLC25A48 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJ06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:HADHB ^@ http://purl.uniprot.org/uniprot/A0A158SIP4|||http://purl.uniprot.org/uniprot/Q8HXX4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. Thiolase family.|||Endoplasmic reticulum|||Heterotetramer of 2 alpha/HADHA and 2 beta/HADHB subunits; forms the mitochondrial trifunctional enzyme. Also purified as higher order heterooligomers including a 4 alpha/HADHA and 4 beta/HADHB heterooligomer which physiological significance remains unclear. The mitochondrial trifunctional enzyme interacts with MTLN. Interacts with RSAD2/viperin.|||Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity.|||Mitochondrion|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:CCDC70 ^@ http://purl.uniprot.org/uniprot/Q4R9C9 ^@ Caution|||Subcellular Location Annotation ^@ It is uncertain whether Met-1 or Met-12 is the initiator.|||Mitochondrion http://togogenome.org/gene/9541:RORB ^@ http://purl.uniprot.org/uniprot/A0A2K5WSZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9541:PELP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RIX1/PELP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:LOC102144453 ^@ http://purl.uniprot.org/uniprot/A0A7N9IDK4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:GNB1 ^@ http://purl.uniprot.org/uniprot/G7NWS9 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9541:SENP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C48 family.|||nucleolus http://togogenome.org/gene/9541:PTAR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4L5|||http://purl.uniprot.org/uniprot/A0A2K5U4M3 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/9541:LYRM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WA91|||http://purl.uniprot.org/uniprot/G7Q0N4 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9541:CD46 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCL8|||http://purl.uniprot.org/uniprot/A0A2K5WCM2|||http://purl.uniprot.org/uniprot/A0A2K5WCS2 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||acrosome inner membrane http://togogenome.org/gene/9541:PLCG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W153|||http://purl.uniprot.org/uniprot/G7PZU5 ^@ Function ^@ Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. http://togogenome.org/gene/9541:GSG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY31|||http://purl.uniprot.org/uniprot/A0A2K5WY44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/9541:ZHX2 ^@ http://purl.uniprot.org/uniprot/G7PCR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/9541:SEC31B ^@ http://purl.uniprot.org/uniprot/A0A2K5VGB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC31 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:SIN3A ^@ http://purl.uniprot.org/uniprot/A0A2K5U3F5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:JPT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9L0|||http://purl.uniprot.org/uniprot/A0A2K5V9L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:LOC102122596 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUZ8 ^@ Similarity ^@ Belongs to the UPF0488 family. http://togogenome.org/gene/9541:GPAT4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WA72|||http://purl.uniprot.org/uniprot/A0A7N9DCX4 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9541:SMIM19 ^@ http://purl.uniprot.org/uniprot/A0A8J8XIJ5|||http://purl.uniprot.org/uniprot/G7PBS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM19 family.|||Membrane http://togogenome.org/gene/9541:HNMT ^@ http://purl.uniprot.org/uniprot/A0A2K5VBJ8|||http://purl.uniprot.org/uniprot/I7GMY1 ^@ Function|||Subunit ^@ Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.|||Monomer. http://togogenome.org/gene/9541:CYP4F8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WU79 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:TPST1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8G6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein sulfotransferase family.|||Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.|||Golgi apparatus membrane http://togogenome.org/gene/9541:SENP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W659 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9541:TIPRL ^@ http://purl.uniprot.org/uniprot/A0A2K5VUG0 ^@ Similarity ^@ Belongs to the TIP41 family. http://togogenome.org/gene/9541:UBE2D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRH8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:SATB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/9541:NPY2R ^@ http://purl.uniprot.org/uniprot/A0A2K5UGU6|||http://purl.uniprot.org/uniprot/G7P6G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102122758 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1L0|||http://purl.uniprot.org/uniprot/A0A7N9I9L6 ^@ Similarity ^@ Belongs to the fl(2)d family. http://togogenome.org/gene/9541:SARS2 ^@ http://purl.uniprot.org/uniprot/Q4R4T1 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. http://togogenome.org/gene/9541:FGGY ^@ http://purl.uniprot.org/uniprot/A0A2K5WK13 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/9541:GSK3B ^@ http://purl.uniprot.org/uniprot/A0A2K5U1P9|||http://purl.uniprot.org/uniprot/A0A2K5U1V1|||http://purl.uniprot.org/uniprot/A0A2K5U1X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:AKR7A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSB5 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/9541:WNT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZH3|||http://purl.uniprot.org/uniprot/G7PHR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:LIM2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y6W6|||http://purl.uniprot.org/uniprot/G7PYH7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis. http://togogenome.org/gene/9541:TCTN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYQ3 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/9541:MYOG ^@ http://purl.uniprot.org/uniprot/A0A2K5VH44 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CYGB ^@ http://purl.uniprot.org/uniprot/A0A2K5W989|||http://purl.uniprot.org/uniprot/A0A2K5W9D1 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9541:HNRNPA2B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0D5|||http://purl.uniprot.org/uniprot/I7G895 ^@ Subcellular Location Annotation ^@ Cytoplasmic granule|||extracellular exosome http://togogenome.org/gene/9541:RPS12 ^@ http://purl.uniprot.org/uniprot/A0A8J8YCC6|||http://purl.uniprot.org/uniprot/G7P346 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/9541:TMEM265 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDS6 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:RC3H1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WM56 ^@ Subcellular Location Annotation ^@ P-body http://togogenome.org/gene/9541:ODR4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8C2|||http://purl.uniprot.org/uniprot/A0A2K5V8C9 ^@ Function|||Similarity ^@ Belongs to the ODR-4 family.|||May play a role in the trafficking of a subset of G-protein coupled receptors. http://togogenome.org/gene/9541:HSD3B2 ^@ http://purl.uniprot.org/uniprot/Q2XQY4 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9541:LOC102116377 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9541:RPS6KA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U291 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:SV2A ^@ http://purl.uniprot.org/uniprot/A0A2K5WGW9|||http://purl.uniprot.org/uniprot/G7NTR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9541:RAB2A ^@ http://purl.uniprot.org/uniprot/Q4R4X6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small GTPase superfamily. Rab family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Interacts with PRKCI. Interacts with TRIP11 (By similarity). Interacts (in GTP-bound form) with GARIN1B (By similarity).|||Melanosome|||The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi.|||acrosome http://togogenome.org/gene/9541:DEFB1 ^@ http://purl.uniprot.org/uniprot/P61261 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta-defensin family.|||Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.|||Membrane|||Monomer. Homodimer.|||Secreted http://togogenome.org/gene/9541:SLC5A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9541:HS6ST3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X627 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/9541:HBE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIW1|||http://purl.uniprot.org/uniprot/G8F3D2 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9541:FKBP6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W696|||http://purl.uniprot.org/uniprot/A0A8J8XF26|||http://purl.uniprot.org/uniprot/G7P173 ^@ Function|||Similarity ^@ Belongs to the FKBP6 family.|||Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes. http://togogenome.org/gene/9541:INO80 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMV7|||http://purl.uniprot.org/uniprot/G7PAY2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.|||Belongs to the SNF2/RAD54 helicase family.|||Component of the INO80 chromatin-remodeling complex.|||Nucleus|||The DBINO region is involved in binding to DNA. http://togogenome.org/gene/9541:LOC102133286 ^@ http://purl.uniprot.org/uniprot/A0A8J8XD17|||http://purl.uniprot.org/uniprot/G7Q3A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9541:DNASE1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CGN5|||http://purl.uniprot.org/uniprot/A0A7N9I9E6 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9541:TMEM129 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM129 family.|||Membrane http://togogenome.org/gene/9541:SLC35F4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/9541:MOK ^@ http://purl.uniprot.org/uniprot/Q4R5J8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:HOMER1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U708 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/9541:SPTAN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKZ4|||http://purl.uniprot.org/uniprot/A0A2K5VL04|||http://purl.uniprot.org/uniprot/A0A2K5VL15|||http://purl.uniprot.org/uniprot/A0A2K5VL65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spectrin family.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9541:TBCB ^@ http://purl.uniprot.org/uniprot/I7GAX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCB family.|||Cytoplasm http://togogenome.org/gene/9541:SEC24C ^@ http://purl.uniprot.org/uniprot/A0A2K5U7M0|||http://purl.uniprot.org/uniprot/A0A7N9D9T7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9541:LOC102115806 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GLMP family.|||Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.|||Lysosome membrane|||Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization. http://togogenome.org/gene/9541:TRHDE ^@ http://purl.uniprot.org/uniprot/A0A2K5VLJ7 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/9541:LZIC ^@ http://purl.uniprot.org/uniprot/A0A2K5WIK2|||http://purl.uniprot.org/uniprot/G7NU54 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/9541:USP9X ^@ http://purl.uniprot.org/uniprot/A0A2K5V070|||http://purl.uniprot.org/uniprot/G7Q2J0 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9541:PSMB7 ^@ http://purl.uniprot.org/uniprot/I7GL24 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. http://togogenome.org/gene/9541:SPIC ^@ http://purl.uniprot.org/uniprot/A0A2K5WBK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:CERS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VI72 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9541:SSH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7B4|||http://purl.uniprot.org/uniprot/A0A2K5V7B9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/9541:TMEM63B ^@ http://purl.uniprot.org/uniprot/A0A7N9ICI8|||http://purl.uniprot.org/uniprot/A0A8J8YDD7|||http://purl.uniprot.org/uniprot/G7P403 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/9541:LOC102127570 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKI9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:HLF ^@ http://purl.uniprot.org/uniprot/A0A2K5V5N8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9541:ISCA1 ^@ http://purl.uniprot.org/uniprot/Q4R5F0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HesB/IscA family.|||Interacts with CRY2, but not with CRY1 (in vitro).|||Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.|||Mitochondrion http://togogenome.org/gene/9541:TMEM53 ^@ http://purl.uniprot.org/uniprot/A0A8J8XIR8|||http://purl.uniprot.org/uniprot/G7NUY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM53 family.|||Membrane|||Nucleus outer membrane http://togogenome.org/gene/9541:ACP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKD7|||http://purl.uniprot.org/uniprot/A0A7N9IEE2|||http://purl.uniprot.org/uniprot/G7PLI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.|||Belongs to the low molecular weight phosphotyrosine protein phosphatase family.|||Cytoplasm http://togogenome.org/gene/9541:EPHA6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U305 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ESYT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the extended synaptotagmin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:OC90 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4V8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9541:ST8SIA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:CREG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CREG family.|||Secreted http://togogenome.org/gene/9541:SIM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6D0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PLPPR5 ^@ http://purl.uniprot.org/uniprot/A0A2K5W213 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9541:BORCS8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TK12|||http://purl.uniprot.org/uniprot/A0A2K5V483|||http://purl.uniprot.org/uniprot/G7PX11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS8 family.|||Lysosome membrane|||Membrane|||Nucleus http://togogenome.org/gene/9541:CX3CR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJQ4|||http://purl.uniprot.org/uniprot/I7G315 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.|||Membrane http://togogenome.org/gene/9541:WASF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYW2|||http://purl.uniprot.org/uniprot/G8F546 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9541:CYFIP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYFIP family.|||synaptosome http://togogenome.org/gene/9541:TFAP2B ^@ http://purl.uniprot.org/uniprot/A0A2K5WSA6 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9541:HK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U647 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9541:GIMAP8 ^@ http://purl.uniprot.org/uniprot/A0A8J8YKR5|||http://purl.uniprot.org/uniprot/G7P201 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9541:FAM110B ^@ http://purl.uniprot.org/uniprot/A0A8J8XF66|||http://purl.uniprot.org/uniprot/G7PBW3 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9541:MICOS13 ^@ http://purl.uniprot.org/uniprot/G7PYT4|||http://purl.uniprot.org/uniprot/Q2ACH7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic13 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MICOS10/MIC10 into the MICOS complex.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOO/MIC26, MICOS13/MIC13, APOOL/MIC27 and IMMT/MIC60. The complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2, and with HSPA9.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:LOC102127060 ^@ http://purl.uniprot.org/uniprot/Q2I6K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:METAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZJ5 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.|||Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).|||Cytoplasm|||Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. http://togogenome.org/gene/9541:SLC9A8 ^@ http://purl.uniprot.org/uniprot/Q4R8V4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Golgi apparatus membrane|||Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity). http://togogenome.org/gene/9541:INSRR ^@ http://purl.uniprot.org/uniprot/A0A2K5WPK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/9541:CCM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWK8|||http://purl.uniprot.org/uniprot/A0A2K5TWM1|||http://purl.uniprot.org/uniprot/A0A2K5TWM5|||http://purl.uniprot.org/uniprot/A0A2K5TWN1|||http://purl.uniprot.org/uniprot/A0A2K5TWQ3|||http://purl.uniprot.org/uniprot/A0A7N9CYN3|||http://purl.uniprot.org/uniprot/A0A7N9D2V5 ^@ Similarity ^@ Belongs to the CCM2 family. http://togogenome.org/gene/9541:SCN2A ^@ http://purl.uniprot.org/uniprot/A0A2K5TT06|||http://purl.uniprot.org/uniprot/A0A2K5TT46|||http://purl.uniprot.org/uniprot/A0A2K5TT52|||http://purl.uniprot.org/uniprot/A0A2K5U6I4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9541:NBN ^@ http://purl.uniprot.org/uniprot/E5FGN1 ^@ Subcellular Location Annotation ^@ Nucleus|||telomere http://togogenome.org/gene/9541:CHN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6S1|||http://purl.uniprot.org/uniprot/A0A2K5V6V5 ^@ Function ^@ GTPase-activating protein for p21-rac. http://togogenome.org/gene/9541:GPR68 ^@ http://purl.uniprot.org/uniprot/A0A2K5UC27|||http://purl.uniprot.org/uniprot/G7PBB1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:DNAH12 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTV2 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/9541:EYA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJL8|||http://purl.uniprot.org/uniprot/A0A2K5TJM3|||http://purl.uniprot.org/uniprot/A0A2K5TJP0|||http://purl.uniprot.org/uniprot/A0A2K5TJP4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:TBX20 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y975|||http://purl.uniprot.org/uniprot/G7P0F2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:POP7 ^@ http://purl.uniprot.org/uniprot/A0A8J8XVN3|||http://purl.uniprot.org/uniprot/G7P0D3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone-like Alba family.|||Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.|||Cytoplasmic granule|||nucleolus http://togogenome.org/gene/9541:RGMA ^@ http://purl.uniprot.org/uniprot/Q9N0A6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds.|||Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Interacts with NEO1, BMP2 and BMP4.|||Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8 (By similarity). http://togogenome.org/gene/9541:PCK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9M9|||http://purl.uniprot.org/uniprot/G7P9X2 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/9541:PIGZ ^@ http://purl.uniprot.org/uniprot/A0A2K5VWI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:TUBB6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9541:CD99L2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGR7|||http://purl.uniprot.org/uniprot/A0A2K5VGX9|||http://purl.uniprot.org/uniprot/A0A2K5VGY3|||http://purl.uniprot.org/uniprot/A0A2K5VGY7 ^@ Similarity ^@ Belongs to the CD99 family. http://togogenome.org/gene/9541:LPCAT2 ^@ http://purl.uniprot.org/uniprot/I7GNW0 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9541:ENDOU ^@ http://purl.uniprot.org/uniprot/A0A2K5TLU3 ^@ Similarity|||Subunit ^@ Belongs to the ENDOU family.|||Monomer. http://togogenome.org/gene/9541:EHF ^@ http://purl.uniprot.org/uniprot/A0A2K5UMJ7|||http://purl.uniprot.org/uniprot/G7PQE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:PHC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9L7|||http://purl.uniprot.org/uniprot/A0A2K5V9N5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:DPRX ^@ http://purl.uniprot.org/uniprot/A0A2K5W0A5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102129652 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2K6|||http://purl.uniprot.org/uniprot/A0A2K5W2L9|||http://purl.uniprot.org/uniprot/A0A2K5W2P4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:G0S2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJD9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.|||Mitochondrion|||Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers. http://togogenome.org/gene/9541:GPR33 ^@ http://purl.uniprot.org/uniprot/A0A7N9CK82 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:PKIA ^@ http://purl.uniprot.org/uniprot/I7GME7 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9541:MFN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCF4 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:INSL5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XP35|||http://purl.uniprot.org/uniprot/G7NW30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9541:UBE2B ^@ http://purl.uniprot.org/uniprot/I7GLU2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:FGF14 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQR6|||http://purl.uniprot.org/uniprot/A0A7N9CAT2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:HHAT ^@ http://purl.uniprot.org/uniprot/A0A2K5WBQ5|||http://purl.uniprot.org/uniprot/A0A2K5WBU1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:AXIN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TM22|||http://purl.uniprot.org/uniprot/A0A2K5TM28|||http://purl.uniprot.org/uniprot/A0A7N9CD25|||http://purl.uniprot.org/uniprot/G7PV72 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:HTR2C ^@ http://purl.uniprot.org/uniprot/A0A2K5UBW0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MPDZ. Interacts with ARRB2.|||Membrane http://togogenome.org/gene/9541:THOP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2Y6 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/9541:SLC18B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0N4|||http://purl.uniprot.org/uniprot/G7P347 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SLC35C1 ^@ http://purl.uniprot.org/uniprot/A0A7N9DCB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TPT transporter family. SLC35C subfamily.|||Membrane http://togogenome.org/gene/9541:KIF21B ^@ http://purl.uniprot.org/uniprot/A0A2K5WZ21|||http://purl.uniprot.org/uniprot/A0A2K5WZB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||cytoskeleton http://togogenome.org/gene/9541:KCTD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4D2 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:CFDP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYF4 ^@ Function|||Subcellular Location Annotation ^@ May play a role during embryogenesis.|||kinetochore http://togogenome.org/gene/9541:DUSP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9541:PSME2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5Y1 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/9541:LOC102119771 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8L2 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9541:GABBR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNP9|||http://purl.uniprot.org/uniprot/A0A7N9DEY1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:NDUFB5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYZ1|||http://purl.uniprot.org/uniprot/A0A2K5VYZ5|||http://purl.uniprot.org/uniprot/G7NZ27|||http://purl.uniprot.org/uniprot/Q4R4E0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:UBQLN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPB3 ^@ Subcellular Location Annotation ^@ Membrane|||Nucleus|||autophagosome http://togogenome.org/gene/9541:GNL1 ^@ http://purl.uniprot.org/uniprot/Q4R8D2 ^@ Domain|||Function|||Similarity ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family.|||In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.|||Possible regulatory or functional link with the histocompatibility cluster. http://togogenome.org/gene/9541:GSX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W595 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CREB3L4 ^@ http://purl.uniprot.org/uniprot/Q5UEM8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family. ATF subfamily.|||Binds DNA as a dimer.|||Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).|||Endoplasmic reticulum membrane|||Nucleus|||Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). http://togogenome.org/gene/9541:SLAIN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZE0|||http://purl.uniprot.org/uniprot/A0A2K5VZH4 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/9541:RITA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEZ6|||http://purl.uniprot.org/uniprot/I7G8X2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RITA family.|||Cytoplasm|||Interacts with RBPJ/RBPSUH.|||Nucleus|||Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis. http://togogenome.org/gene/9541:ARHGDIB ^@ http://purl.uniprot.org/uniprot/A0A2K5X5E9|||http://purl.uniprot.org/uniprot/G7PJY3 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/9541:CPVL ^@ http://purl.uniprot.org/uniprot/A0A2K5X870 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9541:CYP27C1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VX46|||http://purl.uniprot.org/uniprot/G7PLG2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:WIPI2 ^@ http://purl.uniprot.org/uniprot/Q4R757 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PROPPIN family.|||Preautophagosomal structure membrane http://togogenome.org/gene/9541:PSMB5 ^@ http://purl.uniprot.org/uniprot/I7GKX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:CSH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/9541:LOC102139903 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPN3|||http://purl.uniprot.org/uniprot/G7P2Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:EIF2S1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XGJ1|||http://purl.uniprot.org/uniprot/G7PAK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Stress granule http://togogenome.org/gene/9541:CLCA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWV9 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/9541:STARD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBN4|||http://purl.uniprot.org/uniprot/A0A2K5VBS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9541:WBP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFB1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PPEF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0C2|||http://purl.uniprot.org/uniprot/A0A8J8Y5I8|||http://purl.uniprot.org/uniprot/Q4R4Y0 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/9541:CLCF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WX50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9541:SLCO1A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5I2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:NPPA ^@ http://purl.uniprot.org/uniprot/A0A2K5VBM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the natriuretic peptide family.|||Cell projection|||Homodimer; disulfide-linked antiparallel dimer.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.|||May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.|||Secreted http://togogenome.org/gene/9541:IGHMBP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIR4 ^@ Similarity ^@ Belongs to the DNA2/NAM7 helicase family. http://togogenome.org/gene/9541:PAGE3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1E7|||http://purl.uniprot.org/uniprot/A0A7N9ICX2 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9541:IL12RB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9541:NDUFA12 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA12 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:OGT ^@ http://purl.uniprot.org/uniprot/A0A2K5TWY1|||http://purl.uniprot.org/uniprot/A0A8J8XT42|||http://purl.uniprot.org/uniprot/G7Q303 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.|||Cell projection|||Mitochondrion membrane http://togogenome.org/gene/9541:NTSR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQ42|||http://purl.uniprot.org/uniprot/G7PFJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:MRPL18 ^@ http://purl.uniprot.org/uniprot/I7GLK7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL18 family. http://togogenome.org/gene/9541:BECN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V236|||http://purl.uniprot.org/uniprot/A0A2K5V238|||http://purl.uniprot.org/uniprot/A0A2K5V263|||http://purl.uniprot.org/uniprot/A0A2K5V2A7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.|||Belongs to the beclin family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Mitochondrion membrane|||Plays a central role in autophagy.|||autophagosome|||trans-Golgi network membrane http://togogenome.org/gene/9541:MEIG1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDF9|||http://purl.uniprot.org/uniprot/G7PEF2 ^@ Function|||Similarity ^@ Belongs to the MEIG1 family.|||Essential for spermiogenesis. http://togogenome.org/gene/9541:RIPPLY1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CJ69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ripply family.|||Nucleus http://togogenome.org/gene/9541:NR1D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:ARHGAP12 ^@ http://purl.uniprot.org/uniprot/Q9BE31 ^@ Function ^@ GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. http://togogenome.org/gene/9541:CLCN6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8D9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:BTG4 ^@ http://purl.uniprot.org/uniprot/A0A7N9D0K2 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9541:GRIA1 ^@ http://purl.uniprot.org/uniprot/A0A7N9D6X7|||http://purl.uniprot.org/uniprot/Q38PU8 ^@ Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.|||Cell membrane|||Early endosome membrane|||Endoplasmic reticulum membrane|||Homotetramer or heterotetramer of pore-forming glutamate receptor subunits (By similarity). Tetramers may be formed by the dimerization of dimers (By similarity). Found in a complex with GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity). Interacts with HIP1 and RASGRF2. Interacts with SYNDIG1 and GRIA2 (By similarity). Interacts with DLG1 (via C-terminus). Interacts with LRFN1. Interacts with PRKG2. Interacts with CNIH2 and CACNG2. Interacts with CACNG5. Interacts (via C-terminus) with PDLIM4 (via LIM domain); this interaction as well as the interaction of PDLIM4 with alpha-actinin is required for their colocalization in early endosomes (By similarity). Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes. Interacts (via PDZ-binding motif) with SHANK3 (via PDZ domain) (By similarity). Interacts with CACNG3; associates GRIA1 with the adapter protein complex 4 (AP-4) to target GRIA1 to the somatodendritic compartment of neurons (By similarity).|||Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).|||Membrane|||Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).|||Phosphorylated at Ser-645. Phosphorylated at Ser-710 by PKC. Phosphorylated at Ser-849 by PKC, PKA and CAMK2. Phosphorylated at Ser-863 by PKC, PKA and PRKG2 (By similarity). Phosphorylation of Ser-863 is reduced by induction of long-term depression and increased by induction of long-term potentiation (By similarity).|||Postsynaptic cell membrane|||Postsynaptic density membrane|||Presynapse|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Recycling endosome membrane|||Synapse|||Synaptic cell membrane|||The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.|||The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.|||dendrite|||dendritic spine http://togogenome.org/gene/9541:NT5C3B ^@ http://purl.uniprot.org/uniprot/A0A2K5U762 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/9541:FSHR ^@ http://purl.uniprot.org/uniprot/P32212 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.|||Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (By similarity). Interacts with ARRB2 (By similarity). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation (By similarity).|||N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.|||Sulfated. http://togogenome.org/gene/9541:PPT1 ^@ http://purl.uniprot.org/uniprot/Q8HXW6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the palmitoyl-protein thioesterase family.|||Glycosylated.|||Interacts with CLN5, ATP5F1A and ATP5F1B.|||Lysosome|||Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons (By similarity).|||Secreted http://togogenome.org/gene/9541:AMT ^@ http://purl.uniprot.org/uniprot/A0A2K5WBL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvT family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9541:ROPN1B ^@ http://purl.uniprot.org/uniprot/Q4R6C5 ^@ Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ 'Ropporin' comes from the Japanese word 'oppo' which means 'tail'.|||Belongs to the ropporin family.|||Homodimer. Interacts with AKAP3 (By similarity). May interact with SPA17 (By similarity). Interacts with RHPN1 (By similarity). Interacts with FSCB; the interaction increases upon spermatozoa capacitation conditions (By similarity).|||Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.|||Sumoylated, sumoylation decreases upon spermatozoa capacitation conditions.|||The RIIa domain mediates interaction with AKAP3.|||flagellum http://togogenome.org/gene/9541:METTL26 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWH8|||http://purl.uniprot.org/uniprot/A0A2K5UWP3 ^@ Similarity ^@ Belongs to the UPF0585 family. http://togogenome.org/gene/9541:TRAM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W093 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/9541:GABRA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WF04|||http://purl.uniprot.org/uniprot/A0A2K5WF28|||http://purl.uniprot.org/uniprot/A0A7N9DDH1|||http://purl.uniprot.org/uniprot/G8F2J4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/9541:BAK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMM2 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9541:EPAS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDY2|||http://purl.uniprot.org/uniprot/G7PM49 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9541:SPNS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUP5|||http://purl.uniprot.org/uniprot/G7Q0T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/9541:LOC102119755 ^@ http://purl.uniprot.org/uniprot/A0A7N9D958 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9541:HSPB8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Cytoplasm|||Displays temperature-dependent chaperone activity.|||Nucleus http://togogenome.org/gene/9541:NLRP7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBR8 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/9541:DPH1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CIM9 ^@ Similarity ^@ Belongs to the DPH1/DPH2 family. DPH1 subfamily. http://togogenome.org/gene/9541:CPSF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTX3|||http://purl.uniprot.org/uniprot/A0A8J8Y521|||http://purl.uniprot.org/uniprot/G7P0A7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex.|||Nucleus http://togogenome.org/gene/9541:PAX4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9541:C4BPB ^@ http://purl.uniprot.org/uniprot/A0A2K5X1I0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:KIF22 ^@ http://purl.uniprot.org/uniprot/A0A2K5WH65|||http://purl.uniprot.org/uniprot/A0A7N9CVD8|||http://purl.uniprot.org/uniprot/Q4R838 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:PARD3B ^@ http://purl.uniprot.org/uniprot/A0A2K5VK58|||http://purl.uniprot.org/uniprot/A0A2K5VK86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR3 family.|||Cell junction|||Endomembrane system http://togogenome.org/gene/9541:MTHFD1L ^@ http://purl.uniprot.org/uniprot/A0A2K5UVG9 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.|||In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. http://togogenome.org/gene/9541:LOC102145365 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVZ5 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9541:NFYA ^@ http://purl.uniprot.org/uniprot/A0A2K5WQS6|||http://purl.uniprot.org/uniprot/A0A7N9DA59|||http://purl.uniprot.org/uniprot/A0A8J8XVK6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus http://togogenome.org/gene/9541:CCDC126 ^@ http://purl.uniprot.org/uniprot/A0A8J8XLQ2|||http://purl.uniprot.org/uniprot/G7P0Q6|||http://purl.uniprot.org/uniprot/I7GKP5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:NR4A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VST3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR4 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:LOC102122444 ^@ http://purl.uniprot.org/uniprot/A0A023JBW8|||http://purl.uniprot.org/uniprot/A0A2K5V6K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:AVIL ^@ http://purl.uniprot.org/uniprot/A0A2K5US22 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/9541:CABIN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWI8|||http://purl.uniprot.org/uniprot/A0A2K5VWR9|||http://purl.uniprot.org/uniprot/A0A2K5VWX3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:BMP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUA8 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9541:LOC102143072 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIA8 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family.|||Monomer. http://togogenome.org/gene/9541:BRI3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W459 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BRI3 family.|||Membrane|||perinuclear region http://togogenome.org/gene/9541:CYP2U1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:RAMP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4M1 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/9541:APOBEC3G ^@ http://purl.uniprot.org/uniprot/Q05JX4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Cytoplasm|||DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA.|||Homodimer.|||Nucleus|||P-body|||The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity. http://togogenome.org/gene/9541:CAMLG ^@ http://purl.uniprot.org/uniprot/I7GK21 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells. http://togogenome.org/gene/9541:ROR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTX7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:LOC102134299 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||nucleolus http://togogenome.org/gene/9541:NME4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UY38 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9541:XRRA1 ^@ http://purl.uniprot.org/uniprot/Q95LL2 ^@ Function|||Subcellular Location Annotation|||Tissue Specificity ^@ Cytoplasm|||Expressed predominantly in testis.|||May be involved in the response of cells to X-ray radiation.|||Nucleus http://togogenome.org/gene/9541:RNF157 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAC7|||http://purl.uniprot.org/uniprot/A0A2K5UAD3|||http://purl.uniprot.org/uniprot/A0A7N9IA45 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin ligase. http://togogenome.org/gene/9541:BUD23 ^@ http://purl.uniprot.org/uniprot/A0A2K5W405 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:LY6H ^@ http://purl.uniprot.org/uniprot/Q4R5M8 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons (By similarity).|||Cell membrane|||Interacts with CHRNA4 and CHRNA7.|||It is uncertain whether Met-1 or Met-6 is the initiator. http://togogenome.org/gene/9541:FAM135B ^@ http://purl.uniprot.org/uniprot/A0A2K5VR07 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/9541:LOC102131393 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0G8 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/9541:CYP26A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WV20 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:ALG8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXV6|||http://purl.uniprot.org/uniprot/A0A2K5TXX0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:LOC102141439 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4H8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:FAH ^@ http://purl.uniprot.org/uniprot/A0A2K5U3A1 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/9541:STEAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTN5|||http://purl.uniprot.org/uniprot/A0A8J8YG83|||http://purl.uniprot.org/uniprot/G7P1U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9541:RIOK1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YEB8|||http://purl.uniprot.org/uniprot/G7P4D1|||http://purl.uniprot.org/uniprot/Q4R7J7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/9541:POMT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/9541:AVPR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHN3|||http://purl.uniprot.org/uniprot/E3VJQ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PTPA ^@ http://purl.uniprot.org/uniprot/A0A2K5TRN4|||http://purl.uniprot.org/uniprot/A0A2K5TRN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9541:SUGCT ^@ http://purl.uniprot.org/uniprot/A0A2K5VFL3 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/9541:ARSB ^@ http://purl.uniprot.org/uniprot/A0A2K5WDQ3 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9541:KCTD20 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6B5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:SCNN1A ^@ http://purl.uniprot.org/uniprot/A0A2K5VAA2|||http://purl.uniprot.org/uniprot/A0A2K5VAB5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:AMBN ^@ http://purl.uniprot.org/uniprot/A0A2K5WK88 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ameloblastin family.|||Involved in the mineralization and structural organization of enamel.|||extracellular matrix http://togogenome.org/gene/9541:KRT7 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4I5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:LTC4S ^@ http://purl.uniprot.org/uniprot/A0A2K5VDB3|||http://purl.uniprot.org/uniprot/A0A7N9D4G3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:PPARGC1A ^@ http://purl.uniprot.org/uniprot/A0A2K5X8F0|||http://purl.uniprot.org/uniprot/A0A2K5X8S3|||http://purl.uniprot.org/uniprot/A0A2K5X8W4 ^@ Subcellular Location Annotation ^@ PML body http://togogenome.org/gene/9541:TIMM22 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUL3|||http://purl.uniprot.org/uniprot/G7PSY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM22 complex.|||Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:DDO ^@ http://purl.uniprot.org/uniprot/A0A2K5TYP1|||http://purl.uniprot.org/uniprot/A0A2K5TYQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/9541:MRPS23 ^@ http://purl.uniprot.org/uniprot/A0A2K5UX56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS23 family.|||Mitochondrion http://togogenome.org/gene/9541:MRPL43 ^@ http://purl.uniprot.org/uniprot/A0A2K5W456 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL43 family.|||Mitochondrion http://togogenome.org/gene/9541:PSMD9 ^@ http://purl.uniprot.org/uniprot/A0A8J8XFE0|||http://purl.uniprot.org/uniprot/G7PJ73 ^@ Similarity ^@ Belongs to the proteasome subunit p27 family. http://togogenome.org/gene/9541:GGA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U969|||http://purl.uniprot.org/uniprot/G7PVD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:FAM72A ^@ http://purl.uniprot.org/uniprot/A0A2K5VIA4|||http://purl.uniprot.org/uniprot/A0A8J8XC11|||http://purl.uniprot.org/uniprot/G7NVB7 ^@ Similarity ^@ Belongs to the FAM72 family. http://togogenome.org/gene/9541:DBNDD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL14 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/9541:PPP4R3A ^@ http://purl.uniprot.org/uniprot/A0A2K5UC38|||http://purl.uniprot.org/uniprot/A0A2K5UC63 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9541:AP3S1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9E9|||http://purl.uniprot.org/uniprot/A0A2K5W9L1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Membrane|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. http://togogenome.org/gene/9541:ANXA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQS9|||http://purl.uniprot.org/uniprot/A0A8J8YR13|||http://purl.uniprot.org/uniprot/G7PBL1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Membrane|||basement membrane http://togogenome.org/gene/9541:GPR6 ^@ http://purl.uniprot.org/uniprot/G8F545 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ALG9 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:CPLANE2 ^@ http://purl.uniprot.org/uniprot/G7NU97 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.|||cilium basal body http://togogenome.org/gene/9541:TMX2 ^@ http://purl.uniprot.org/uniprot/Q4R5B4 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.|||Endoplasmic reticulum membrane|||Mitochondrion membrane|||Monomer (By similarity). Homodimer; disulfide-linked (By similarity). Occurs in both reduced and oxidized monomeric form (By similarity). Oxidative conditions increase homodimerization (By similarity). Interacts with CANX (By similarity). Interacts with ATP2A2 (By similarity).|||The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.|||The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity. http://togogenome.org/gene/9541:MEOX2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4L1|||http://purl.uniprot.org/uniprot/G7P192 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CDC20 ^@ http://purl.uniprot.org/uniprot/G7NUW9|||http://purl.uniprot.org/uniprot/Q4R825 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/9541:ALG13 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHX9|||http://purl.uniprot.org/uniprot/A0A2K5VHY6|||http://purl.uniprot.org/uniprot/A0A2K5VHZ5 ^@ Similarity ^@ Belongs to the glycosyltransferase 28 family. http://togogenome.org/gene/9541:TSPAN18 ^@ http://purl.uniprot.org/uniprot/A0A7N9C837 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:TARBP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFU3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TARBP2 family.|||Cytoplasm|||Nucleus|||Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.|||Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).|||perinuclear region http://togogenome.org/gene/9541:MED20 ^@ http://purl.uniprot.org/uniprot/Q4R4S8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 20 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with PPARG (By similarity).|||Nucleus http://togogenome.org/gene/9541:B4GALNT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane|||Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. http://togogenome.org/gene/9541:GHR ^@ http://purl.uniprot.org/uniprot/A0A2K5WH01|||http://purl.uniprot.org/uniprot/A0A2K5WH03|||http://purl.uniprot.org/uniprot/A0A7N9D090 ^@ Function|||Similarity ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. http://togogenome.org/gene/9541:ITGA7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN90|||http://purl.uniprot.org/uniprot/A0A2K5UNA9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:UBE2E2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQD0 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:VPS8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNM1|||http://purl.uniprot.org/uniprot/A0A2K5VNM2 ^@ Similarity ^@ Belongs to the VPS8 family. http://togogenome.org/gene/9541:GOT2 ^@ http://purl.uniprot.org/uniprot/Q4R559 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.|||Cell membrane|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.|||Mitochondrion matrix http://togogenome.org/gene/9541:MMP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTD3|||http://purl.uniprot.org/uniprot/G7PNK5 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9541:QRSL1 ^@ http://purl.uniprot.org/uniprot/Q4R7R9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9541:ELOF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJK5|||http://purl.uniprot.org/uniprot/G7PZF7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELOF1 family.|||Nucleus|||Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. http://togogenome.org/gene/9541:HESX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANF homeobox family.|||Nucleus http://togogenome.org/gene/9541:AMOTL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U227 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/9541:LOC102134028 ^@ http://purl.uniprot.org/uniprot/A0A2K5VS49|||http://purl.uniprot.org/uniprot/A0A7N9CRH6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NADPH--cytochrome P450 reductase family.|||Binds 1 FAD per monomer.|||Binds 1 FMN per monomer.|||Endoplasmic reticulum membrane|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. http://togogenome.org/gene/9541:SLC2A6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNB1 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9541:PPP2R2A ^@ http://purl.uniprot.org/uniprot/A0A805QTE8|||http://purl.uniprot.org/uniprot/Q4R7Z4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the phosphatase 2A regulatory subunit B family.|||PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). Interacts with TP53 (By similarity). Interacts with IER5 (By similarity). Interacts with MFHAS1; the interaction is direct (By similarity). Interacts with PABIR1/FAM122A (By similarity). Interacts with CRTC3 (By similarity).|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. http://togogenome.org/gene/9541:SKA2 ^@ http://purl.uniprot.org/uniprot/Q4R8E8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SKA2 family.|||Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.|||Component of the SKA1 complex, composed of SKA1, SKA2 and SKA3. Forms a heterodimer with SKA1; the heterodimer interacting with SKA3. The core SKA1 complex is composed of 2 SKA1-SKA2 heterodimers, each heterodimer interacting with a molecule of the SKA3 homodimer. The core SKA1 complex associates with microtubules and forms oligomeric assemblies. Interacts directly with SKA1. Binds directly to microtubules; but with a much lower affinity than SKA1 in vivo (By similarity).|||kinetochore|||spindle http://togogenome.org/gene/9541:RUSF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1R9 ^@ Similarity ^@ Belongs to the RUS1 family. http://togogenome.org/gene/9541:CTNNAL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHR8 ^@ Similarity ^@ Belongs to the vinculin/alpha-catenin family. http://togogenome.org/gene/9541:MTMR12 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Sarcoplasmic reticulum|||sarcomere http://togogenome.org/gene/9541:TMEM176B ^@ http://purl.uniprot.org/uniprot/A0A2K5VMI1|||http://purl.uniprot.org/uniprot/A0A2K5VMR3|||http://purl.uniprot.org/uniprot/G7P208 ^@ Similarity ^@ Belongs to the TMEM176 family. http://togogenome.org/gene/9541:PPP1R14C ^@ http://purl.uniprot.org/uniprot/A0A2K5TWB8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PP1 inhibitor family.|||Inhibitor of PPP1CA.|||Membrane http://togogenome.org/gene/9541:PRRT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZD2 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:MTNR1A ^@ http://purl.uniprot.org/uniprot/C9WTA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.|||Membrane http://togogenome.org/gene/9541:MRPS18A ^@ http://purl.uniprot.org/uniprot/A0A2K5TSW2 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9541:MBL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZY9|||http://purl.uniprot.org/uniprot/G7PDG1|||http://purl.uniprot.org/uniprot/Q66S50 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).|||Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages.|||Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.|||Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2 (By similarity). Interacts with MEP1A and MEP1B and may inhibit their catalytic activity (By similarity).|||Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2 (By similarity). Interacts with MEP1A and MEP1B and may inhibit their catalytic activity.|||Secreted|||The coiled-coil domain mediates trimerization. http://togogenome.org/gene/9541:SLC7A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U070|||http://purl.uniprot.org/uniprot/G7Q2Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:URAD ^@ http://purl.uniprot.org/uniprot/A0A2K5VFU0 ^@ Function|||Similarity ^@ Belongs to the OHCU decarboxylase family.|||Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin. http://togogenome.org/gene/9541:NATD1 ^@ http://purl.uniprot.org/uniprot/A0A7N9C8E1 ^@ Similarity ^@ Belongs to the NATD1 family. http://togogenome.org/gene/9541:ITGAD ^@ http://purl.uniprot.org/uniprot/A0A2K5TKB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9541:DCTN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMT3|||http://purl.uniprot.org/uniprot/A0A2K5TMV2|||http://purl.uniprot.org/uniprot/A0A2K5TMV3|||http://purl.uniprot.org/uniprot/G7PMI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin 150 kDa subunit family.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9541:SARDH ^@ http://purl.uniprot.org/uniprot/A0A2K5WMP9 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/9541:CAPRIN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJU5 ^@ Similarity ^@ Belongs to the caprin family. http://togogenome.org/gene/9541:DYNLT2B ^@ http://purl.uniprot.org/uniprot/A0A2K5V5S9 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9541:DVL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5M5 ^@ Similarity ^@ Belongs to the DSH family. http://togogenome.org/gene/9541:CTU2 ^@ http://purl.uniprot.org/uniprot/A0A2K5USQ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTU2/NCS2 family.|||Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. http://togogenome.org/gene/9541:GDA ^@ http://purl.uniprot.org/uniprot/A0A2K5V8Q6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. http://togogenome.org/gene/9541:GRM4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGS8|||http://purl.uniprot.org/uniprot/A0A2K5VGV9|||http://purl.uniprot.org/uniprot/A0A2K5VGY0|||http://purl.uniprot.org/uniprot/Q1ZZH0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity (By similarity).|||Interacts with PICK1.|||Membrane http://togogenome.org/gene/9541:HAGH ^@ http://purl.uniprot.org/uniprot/A0A2K5WE54|||http://purl.uniprot.org/uniprot/Q4R6C1 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Binds 2 Zn(2+) ions per subunit.|||Cytoplasm|||Mitochondrion matrix|||Monomer.|||Only one single gene encoding glyoxalase II has been identified in vertebrates. In yeast and higher plants, separate genes encode the cytosolic and mitochondrial forms of glyoxalase II.|||Produced by alternative splicing. Also produced by alternative initiation at Met-49 of isoform 1. Alternative initiation has been proven in human.|||Testis.|||Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. http://togogenome.org/gene/9541:EIF4E ^@ http://purl.uniprot.org/uniprot/A0A2K5WU54|||http://purl.uniprot.org/uniprot/A0A2K5WU58|||http://purl.uniprot.org/uniprot/I7GAS4 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9541:EXOC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSX7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SEC5 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||Component of the exocyst complex. http://togogenome.org/gene/9541:SERINC1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y6V0|||http://purl.uniprot.org/uniprot/G7P394 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9541:AMIGO1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XXM3|||http://purl.uniprot.org/uniprot/G7NV59 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. AMIGO family. http://togogenome.org/gene/9541:PDE7A ^@ http://purl.uniprot.org/uniprot/A0A2K5WGM8|||http://purl.uniprot.org/uniprot/A0A8J8XNN1|||http://purl.uniprot.org/uniprot/G7PBY0 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:SLC6A3 ^@ http://purl.uniprot.org/uniprot/A9XCH4|||http://purl.uniprot.org/uniprot/Q9GJT6 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.|||Cell membrane|||Homooligomer; disulfide-linked (By similarity). Interacts with PRKCABP and TGFB1I1 (By similarity). Interacts (via N-terminus) with SYNGR3 (via N-terminus) (By similarity). Interacts with SLC18A2 (By similarity). Interacts with TOR1A (ATP-bound); TOR1A regulates SLC6A3 subcellular location (By similarity). Interacts with alpha-synuclein/SNCA (By similarity). Interacts with SEPTIN4 (By similarity).|||Mediates sodium- and chloride-dependent transport of dopamine (By similarity). Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity).|||Membrane|||This protein is the target of psychomotor stimulants such as amphetamines or cocaine.|||axon|||neuron projection http://togogenome.org/gene/9541:EMSY ^@ http://purl.uniprot.org/uniprot/A0A2K5VWJ6|||http://purl.uniprot.org/uniprot/A0A2K5VWP7|||http://purl.uniprot.org/uniprot/A0A2K5VWT6|||http://purl.uniprot.org/uniprot/A0A8J8YMX9|||http://purl.uniprot.org/uniprot/G7PNA3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:KDM5A ^@ http://purl.uniprot.org/uniprot/A0A2K5TWE4 ^@ Similarity ^@ Belongs to the JARID1 histone demethylase family. http://togogenome.org/gene/9541:MLST8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVA9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LST8 family.|||Cytoplasm|||Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.|||Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA. http://togogenome.org/gene/9541:LOC102138563 ^@ http://purl.uniprot.org/uniprot/A0A2K5V122 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/9541:LOC102140088 ^@ http://purl.uniprot.org/uniprot/A0A2K5V684 ^@ Similarity ^@ Belongs to the strictosidine synthase family. http://togogenome.org/gene/9541:PRELID3B ^@ http://purl.uniprot.org/uniprot/Q4R5S9 ^@ Similarity ^@ Belongs to the slowmo family. http://togogenome.org/gene/9541:LOC102129301 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CHAT ^@ http://purl.uniprot.org/uniprot/A0A2K5VTI9 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9541:IFNG ^@ http://purl.uniprot.org/uniprot/G7PHZ5|||http://purl.uniprot.org/uniprot/P63309 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the type II (or gamma) interferon family.|||Homodimer.|||Homodimer. Interacts with IFNGR1 (via extracellular domain); this interaction promotes IFNGR1 dimerization.|||Released primarily from activated T lymphocytes.|||Secreted|||Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).|||Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation. http://togogenome.org/gene/9541:OAZ2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAI7 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/9541:SGCD ^@ http://purl.uniprot.org/uniprot/A0A2K5UZX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9541:ANXA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W030|||http://purl.uniprot.org/uniprot/G7PSJ7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the annexin family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome membrane|||Lateral cell membrane|||Membrane|||Nucleus|||The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.|||cilium|||extracellular exosome|||extracellular space|||phagocytic cup|||secretory vesicle lumen http://togogenome.org/gene/9541:TMEM87A ^@ http://purl.uniprot.org/uniprot/A0A2K5WC65|||http://purl.uniprot.org/uniprot/A0A8J8XB06|||http://purl.uniprot.org/uniprot/G7PB00|||http://purl.uniprot.org/uniprot/I7GDS0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ETV3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus|||Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. http://togogenome.org/gene/9541:LOC102144852 ^@ http://purl.uniprot.org/uniprot/A0A2K5WG23 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily. http://togogenome.org/gene/9541:MED23 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEW8|||http://purl.uniprot.org/uniprot/A0A2K5UEX8|||http://purl.uniprot.org/uniprot/G7P359 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 23 family.|||Nucleus http://togogenome.org/gene/9541:TTC39A ^@ http://purl.uniprot.org/uniprot/A0A2K5WJ05|||http://purl.uniprot.org/uniprot/A0A2K5WJ45 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/9541:H1-4 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y8N7|||http://purl.uniprot.org/uniprot/G7P2M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9541:GALNT7 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:CDKN1B ^@ http://purl.uniprot.org/uniprot/A0A2K5V146|||http://purl.uniprot.org/uniprot/G7PJW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDI family.|||Cytoplasm|||Endosome|||Nucleus http://togogenome.org/gene/9541:RPL24 ^@ http://purl.uniprot.org/uniprot/P61122 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL24 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm|||Mono-ADP-ribosylation at Glu-4 by PARP16 inhibits polysome assembly and mRNA loading, thereby inhibiting protein translation. http://togogenome.org/gene/9541:MYH3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCX9|||http://purl.uniprot.org/uniprot/A0A2K5UD03 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:LOC102125955 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0B7 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:IL16 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZL5|||http://purl.uniprot.org/uniprot/A0A2K5UZN3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Homotetramer.|||Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.|||Nucleus|||Secreted http://togogenome.org/gene/9541:CHDH ^@ http://purl.uniprot.org/uniprot/A0A2K5U1B5|||http://purl.uniprot.org/uniprot/G7NZU2 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/9541:LOC102138137 ^@ http://purl.uniprot.org/uniprot/G7P2L9|||http://purl.uniprot.org/uniprot/G7P2N0|||http://purl.uniprot.org/uniprot/Q4R362 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.|||Belongs to the histone H4 family.|||Butyrylation of histones marks active promoters and competes with histone acetylation.|||Chromosome|||Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).|||Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.|||Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.|||Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.|||Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).|||Nucleus|||Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).|||Sumoylated, which is associated with transcriptional repression.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).|||Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. http://togogenome.org/gene/9541:TADA1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y822|||http://purl.uniprot.org/uniprot/G7NU37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TADA1 family.|||Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.|||Nucleus|||Probably involved in transcriptional regulation. http://togogenome.org/gene/9541:ADRB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UI86|||http://purl.uniprot.org/uniprot/G7P8M7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.|||Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.|||Cell membrane|||Early endosome|||Golgi apparatus|||Membrane http://togogenome.org/gene/9541:LOC102118616 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PYROXD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UA44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.|||sarcomere http://togogenome.org/gene/9541:SUPT3H ^@ http://purl.uniprot.org/uniprot/A0A2K5UI13 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PFDN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9W8 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/9541:LOC102122418 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3G2|||http://purl.uniprot.org/uniprot/G7Q2H9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SAMD4A ^@ http://purl.uniprot.org/uniprot/A0A2K5VV40|||http://purl.uniprot.org/uniprot/A0A2K5VVG8|||http://purl.uniprot.org/uniprot/Q95LV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a translational repressor of SRE-containing messengers.|||Belongs to the SMAUG family.|||Cytoplasm|||dendrite|||synaptosome http://togogenome.org/gene/9541:IPO5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U190|||http://purl.uniprot.org/uniprot/Q4R8T7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:MOCS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5URB1 ^@ Similarity ^@ In the C-terminal section; belongs to the MoaC family.|||In the N-terminal section; belongs to the radical SAM superfamily. MoaA family. http://togogenome.org/gene/9541:LIX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7H8 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/9541:PPP1R3C ^@ http://purl.uniprot.org/uniprot/A0A2K5X6W1 ^@ Domain|||Function|||Subunit ^@ Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.|||Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.|||The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase. http://togogenome.org/gene/9541:FAM229B ^@ http://purl.uniprot.org/uniprot/A5LFY3|||http://purl.uniprot.org/uniprot/G7P3M5 ^@ Similarity ^@ Belongs to the FAM229 family. http://togogenome.org/gene/9541:ZNF326 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLL0 ^@ Similarity ^@ Belongs to the AKAP95 family. http://togogenome.org/gene/9541:AKTIP ^@ http://purl.uniprot.org/uniprot/Q4R5E1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.|||Cell membrane|||Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FHIP1B, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. Interacts directly with HOOK1, HOOK2 and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex). Also interacts with AKT1. May interact with FHIP1A.|||Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.|||Cytoplasm|||Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity. http://togogenome.org/gene/9541:PSMA7 ^@ http://purl.uniprot.org/uniprot/A0A2K5X9B7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9541:HSPH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIW1|||http://purl.uniprot.org/uniprot/A0A2K5UIX0|||http://purl.uniprot.org/uniprot/A0A7N9CYX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm http://togogenome.org/gene/9541:GAL3ST1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPT1 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/9541:SLC20A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAN6|||http://purl.uniprot.org/uniprot/G7PBR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. http://togogenome.org/gene/9541:LOC102142503 ^@ http://purl.uniprot.org/uniprot/G7NZE1 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9541:MLEC ^@ http://purl.uniprot.org/uniprot/A0A2K5UV44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the malectin family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:TENM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2F0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family. Teneurin subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:SEZ6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPJ4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:YPEL4 ^@ http://purl.uniprot.org/uniprot/G7PQ32|||http://purl.uniprot.org/uniprot/Q25NF5 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9541:PRSS12 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTZ6 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.|||Secreted http://togogenome.org/gene/9541:SUGT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAP2 ^@ Similarity ^@ Belongs to the SGT1 family. http://togogenome.org/gene/9541:RRP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8E3 ^@ Similarity ^@ Belongs to the RRP1 family. http://togogenome.org/gene/9541:HNF4A ^@ http://purl.uniprot.org/uniprot/A0A2K5VA24|||http://purl.uniprot.org/uniprot/A0A2K5VA29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:CPA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0D2 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9541:YPEL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCK4 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9541:LOC102127391 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCG6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:HAPLN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X326 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:HMGA1 ^@ http://purl.uniprot.org/uniprot/I7GET7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HMGA family.|||Chromosome|||HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.|||Interacts with HIPK2.|||Nucleus http://togogenome.org/gene/9541:SPTA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spectrin family.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9541:SERPINA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHF8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:OSBPL6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WF67|||http://purl.uniprot.org/uniprot/A0A2K5WF71|||http://purl.uniprot.org/uniprot/A0A2K5WF76|||http://purl.uniprot.org/uniprot/A0A2K5WFF0|||http://purl.uniprot.org/uniprot/A0A8J8YEW8|||http://purl.uniprot.org/uniprot/G7PKX7 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9541:SLC25A31 ^@ http://purl.uniprot.org/uniprot/G7P691|||http://purl.uniprot.org/uniprot/Q4R8M0 ^@ Activity Regulation|||Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). Specifically required during spermatogenesis, probably to mediate ADP:ATP exchange in spermatocytes. Large ATP supplies from mitochondria may be critical for normal progression of spermatogenesis during early stages of meiotic prophase I, including DNA double-strand break repair and chromosomal synapsis. In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A31/ANT4 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A31/ANT4 constitutes a pore-forming component of mPTP or regulates it (By similarity).|||Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion inner membrane|||Monomer.|||The matrix-open state (m-state) is inhibited by the membrane-permeable bongkrekic acid (BKA). The cytoplasmic-open state (c-state) is inhibited by the membrane-impermeable toxic inhibitor carboxyatractyloside (CATR) (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity (By similarity).|||The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.|||flagellum membrane http://togogenome.org/gene/9541:NID1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UK97 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9541:RRAGA ^@ http://purl.uniprot.org/uniprot/I7G5F0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9541:ANAPC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3D1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC5 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||spindle http://togogenome.org/gene/9541:GRM3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYC3|||http://purl.uniprot.org/uniprot/G7P1W4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.|||Interacts with TAMALIN.|||Membrane http://togogenome.org/gene/9541:TGIF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8Q8|||http://purl.uniprot.org/uniprot/I7GDB5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FFAR1 ^@ http://purl.uniprot.org/uniprot/Q76JV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation. http://togogenome.org/gene/9541:KCNG4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKK7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:SLC18A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UE16 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:RNF125 ^@ http://purl.uniprot.org/uniprot/Q95KF1 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Autoubiquitinated, leading to its subsequent proteasomal degradation.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as RIGI, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of RIGI at 'Lys-181', leading to RIGI degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation.|||Golgi apparatus membrane|||Interacts with UBE2D1. Interacts with VCP/p97; leading to recruit RNF125 to RIGI and promote ubiquitination of RIGI.|||The C2HC RNF-type zinc finger and the linker region stabilize the RING-type zinc finger, leading to promote binding of the RING-type zinc finger to the ubiquitin-conjugating enzyme E2 (donor ubiquitin). http://togogenome.org/gene/9541:RFC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKM6|||http://purl.uniprot.org/uniprot/G8F2Q2 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/9541:EMC7 ^@ http://purl.uniprot.org/uniprot/G7PAN8|||http://purl.uniprot.org/uniprot/Q4R5V2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC7 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. http://togogenome.org/gene/9541:CCDC96 ^@ http://purl.uniprot.org/uniprot/Q95LS7 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/9541:CA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3L9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alpha-carbonic anhydrase family.|||Cell membrane|||Interacts with SLC4A4.|||Membrane|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9541:RIC3 ^@ http://purl.uniprot.org/uniprot/G7PQS9 ^@ Similarity ^@ Belongs to the ric-3 family. http://togogenome.org/gene/9541:SAR1A ^@ http://purl.uniprot.org/uniprot/A0A2K5WYE8|||http://purl.uniprot.org/uniprot/G7PF44|||http://purl.uniprot.org/uniprot/I7GKR3 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family.|||Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9541:AUH ^@ http://purl.uniprot.org/uniprot/A0A2K5WCU2|||http://purl.uniprot.org/uniprot/A0A2K5WCX1 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9541:HECTD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGR6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:RPL37 ^@ http://purl.uniprot.org/uniprot/A0A7N9IBE1 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/9541:TLCD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4Y4|||http://purl.uniprot.org/uniprot/A0A2K5W538 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:FAXDC2 ^@ http://purl.uniprot.org/uniprot/Q9GKT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sterol desaturase family.|||Cytoplasm|||Membrane|||Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression. http://togogenome.org/gene/9541:ALAS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9X2|||http://purl.uniprot.org/uniprot/A0A2K5WA41|||http://purl.uniprot.org/uniprot/G7Q2U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:PGM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WE15 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9541:ZNF483 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVJ3|||http://purl.uniprot.org/uniprot/G8F3G3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:REN ^@ http://purl.uniprot.org/uniprot/A0A2K5U9N0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A1 family.|||Interacts with ATP6AP2.|||Membrane|||Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.|||Secreted http://togogenome.org/gene/9541:SLC15A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCX4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/9541:ZNF277 ^@ http://purl.uniprot.org/uniprot/A0A2K5U610|||http://purl.uniprot.org/uniprot/G7P2H1 ^@ Similarity ^@ Belongs to the ZNF277 family. http://togogenome.org/gene/9541:ZNF668 ^@ http://purl.uniprot.org/uniprot/Q4R3I5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:ADGRV1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3R1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:COL4A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8K5 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9541:PIGN ^@ http://purl.uniprot.org/uniprot/A0A2K5VN51|||http://purl.uniprot.org/uniprot/G7PWW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.|||Endoplasmic reticulum membrane|||Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.|||Membrane http://togogenome.org/gene/9541:UPRT ^@ http://purl.uniprot.org/uniprot/Q95KB0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPRTase family.|||Cytoplasm|||Nucleus|||The uracil binding region known from UPRTases is missing. http://togogenome.org/gene/9541:HSPB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UR85|||http://purl.uniprot.org/uniprot/G7P7H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/9541:MDFI ^@ http://purl.uniprot.org/uniprot/A0A2K5UCB9 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/9541:SSR4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAD8|||http://purl.uniprot.org/uniprot/G7Q200 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-delta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9541:MMP19 ^@ http://purl.uniprot.org/uniprot/A0A2K5U112 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9541:IFI6 ^@ http://purl.uniprot.org/uniprot/Q25Q84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/9541:SGCA ^@ http://purl.uniprot.org/uniprot/A0A2K5UMZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan alpha/epsilon family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.|||cytoskeleton http://togogenome.org/gene/9541:EIF3F ^@ http://purl.uniprot.org/uniprot/Q4R5B8 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit F family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner. Interacts with DTX1, the interaction is required for deubiquitinating activity towards NOTCH1 (By similarity).|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.|||Phosphorylation is enhanced upon serum stimulation. Phosphorylated during apoptosis by caspase-processed CDK11 (By similarity).|||The MPN domain mediates deubiquitinating activity. http://togogenome.org/gene/9541:MACO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0M4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the macoilin family.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane|||Plays a role in the regulation of neuronal activity.|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/9541:BICC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQC8|||http://purl.uniprot.org/uniprot/A0A2K5WQN6 ^@ Similarity ^@ Belongs to the BicC family. http://togogenome.org/gene/9541:ASB6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDT3|||http://purl.uniprot.org/uniprot/A0A2K5UDT7 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:MYCN ^@ http://purl.uniprot.org/uniprot/A0A2K5V4C0 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/9541:NCALD ^@ http://purl.uniprot.org/uniprot/Q4R4N4 ^@ Function|||Similarity ^@ Belongs to the recoverin family.|||May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity). http://togogenome.org/gene/9541:RIOK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V606 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/9541:SLC39A12 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNC0|||http://purl.uniprot.org/uniprot/Q95KA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a zinc-influx transporter.|||Belongs to the ZIP transporter (TC 2.A.5) family.|||Membrane http://togogenome.org/gene/9541:TAS2R16 ^@ http://purl.uniprot.org/uniprot/A0A7N9CVE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9541:LOC102118468 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ55 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. http://togogenome.org/gene/9541:LOC102125835 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQ11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.|||Nucleus http://togogenome.org/gene/9541:LOC102131403 ^@ http://purl.uniprot.org/uniprot/A0A7N9CW39 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9541:B2M ^@ http://purl.uniprot.org/uniprot/I7GKX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-2-microglobulin family.|||Secreted http://togogenome.org/gene/9541:PHKA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ96|||http://purl.uniprot.org/uniprot/A0A2K5WQA7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. http://togogenome.org/gene/9541:TRABD2B ^@ http://purl.uniprot.org/uniprot/A0A2K5WCM5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TIKI family.|||Cell membrane|||Divalent metal cations. Mn(2+) or Co(2+).|||Membrane|||Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. http://togogenome.org/gene/9541:COPB2 ^@ http://purl.uniprot.org/uniprot/Q4R4I8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat COPB2 family.|||COPI-coated vesicle membrane|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Probably interacts with PEX11A. Interacts with SCYL1. Interacts with JAGN1 (By similarity).|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).|||This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity).|||cytosol http://togogenome.org/gene/9541:LOC102123076 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSZ9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/9541:UROC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ18 ^@ Similarity ^@ Belongs to the urocanase family. http://togogenome.org/gene/9541:DAND5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X611 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/9541:LHFPL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3H9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:DHX15 ^@ http://purl.uniprot.org/uniprot/A0A2K5WB33 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily. http://togogenome.org/gene/9541:LOC102119972 ^@ http://purl.uniprot.org/uniprot/I7GNA2 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/9541:KEG98_p12 ^@ http://purl.uniprot.org/uniprot/C3W4Y6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 2 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:PARL ^@ http://purl.uniprot.org/uniprot/I7GIY6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102133631 ^@ http://purl.uniprot.org/uniprot/A0A7N9CTH0 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Membrane|||Mitochondrion inner membrane|||The Rieske protein is a high potential 2Fe-2S protein. http://togogenome.org/gene/9541:YDJC ^@ http://purl.uniprot.org/uniprot/A0A2K5WWD4 ^@ Function|||Similarity ^@ Belongs to the YdjC deacetylase family.|||Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides. http://togogenome.org/gene/9541:EFS ^@ http://purl.uniprot.org/uniprot/A0A2K5TRI6|||http://purl.uniprot.org/uniprot/A0A7N9D1U2 ^@ Similarity ^@ Belongs to the CAS family. http://togogenome.org/gene/9541:ELMO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXT1|||http://purl.uniprot.org/uniprot/A0A2K5TXT2|||http://purl.uniprot.org/uniprot/A0A7N9CBV5|||http://purl.uniprot.org/uniprot/A0A7N9CBY5 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/9541:CAB39L ^@ http://purl.uniprot.org/uniprot/A0A8J8XN18|||http://purl.uniprot.org/uniprot/G7PVE7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/9541:CLTC ^@ http://purl.uniprot.org/uniprot/A0A2K5X3T4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin heavy chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||Membrane|||coated pit http://togogenome.org/gene/9541:SCN3A ^@ http://purl.uniprot.org/uniprot/A0A2K5VS58|||http://purl.uniprot.org/uniprot/A0A2K5VS92 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9541:LOC102125303 ^@ http://purl.uniprot.org/uniprot/A0A2K5U974|||http://purl.uniprot.org/uniprot/A0A2K5U979|||http://purl.uniprot.org/uniprot/A0A2K5U980 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/9541:RFFL ^@ http://purl.uniprot.org/uniprot/A0A2K5TJB7 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:MRPS18C ^@ http://purl.uniprot.org/uniprot/A0A2K5WDE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Mitochondrion http://togogenome.org/gene/9541:LOC102143999 ^@ http://purl.uniprot.org/uniprot/A0A2K5TK21|||http://purl.uniprot.org/uniprot/A0A2K5TK66 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9541:MAU2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWV5|||http://purl.uniprot.org/uniprot/A0A2K5VWW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCC4/mau-2 family.|||nucleoplasm http://togogenome.org/gene/9541:LOC102139511 ^@ http://purl.uniprot.org/uniprot/A0A2K5UP59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:NAE1 ^@ http://purl.uniprot.org/uniprot/Q2PFN1|||http://purl.uniprot.org/uniprot/Q4R3L6 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.|||Binding of TP53BP2 to the regulatory subunit NAE1 decreases neddylation activity.|||Cell membrane|||Heterodimer of UBA3 and NAE1. The complex binds NEDD8 and UBE2M. Binds APP and TP53BP2 (By similarity).|||Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.|||Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation (By similarity).|||Ubiquitinated by TRIP12, leading to its degradation by the proteasome. http://togogenome.org/gene/9541:AKT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8I8|||http://purl.uniprot.org/uniprot/A0A2K5V8J4|||http://purl.uniprot.org/uniprot/A0A7N9CEN6|||http://purl.uniprot.org/uniprot/A0A7N9IGM4|||http://purl.uniprot.org/uniprot/A0A8J8YC63|||http://purl.uniprot.org/uniprot/G7NWL3 ^@ Similarity ^@ Belongs to the protein kinase superfamily.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/9541:MRPS21 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y104|||http://purl.uniprot.org/uniprot/G7NTS9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/9541:POLR3A ^@ http://purl.uniprot.org/uniprot/A0A8J8YMI0|||http://purl.uniprot.org/uniprot/G7PEY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9541:CDH7 ^@ http://purl.uniprot.org/uniprot/A0A8J8YM50|||http://purl.uniprot.org/uniprot/G7PW74 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:NLRP14 ^@ http://purl.uniprot.org/uniprot/A0A2K5UP25 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/9541:ZDHHC12 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZA4 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:CLU ^@ http://purl.uniprot.org/uniprot/A0A2K5VV75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clusterin family.|||Endoplasmic reticulum|||Membrane|||Microsome|||Mitochondrion membrane|||Nucleus|||Secreted|||chromaffin granule|||cytosol|||perinuclear region http://togogenome.org/gene/9541:IAH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPY2|||http://purl.uniprot.org/uniprot/A0A7N9DFY3 ^@ Function|||Similarity ^@ Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.|||Probable lipase. http://togogenome.org/gene/9541:SLC16A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWK4|||http://purl.uniprot.org/uniprot/A0A2K5WWT1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:DDI2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZ37 ^@ Similarity ^@ Belongs to the DDI1 family. http://togogenome.org/gene/9541:LOC102126587 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ91 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9541:ATRX ^@ http://purl.uniprot.org/uniprot/A0A2K5V081|||http://purl.uniprot.org/uniprot/A0A2K5V0F0 ^@ Subcellular Location Annotation ^@ Nucleus|||telomere http://togogenome.org/gene/9541:ARHGEF12 ^@ http://purl.uniprot.org/uniprot/A0A2K5TU65|||http://purl.uniprot.org/uniprot/A0A2K5TU72|||http://purl.uniprot.org/uniprot/A0A2K5TU81 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Membrane http://togogenome.org/gene/9541:GIPR ^@ http://purl.uniprot.org/uniprot/A0A2K5VD75 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ISCU ^@ http://purl.uniprot.org/uniprot/I7GEK8 ^@ Function|||Similarity ^@ Belongs to the NifU family.|||Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. http://togogenome.org/gene/9541:LOC102120741 ^@ http://purl.uniprot.org/uniprot/G7P2L6|||http://purl.uniprot.org/uniprot/G7P2M7|||http://purl.uniprot.org/uniprot/G7P2P0 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:BRS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TT26 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with C6orf89.|||Membrane http://togogenome.org/gene/9541:SLC9A9 ^@ http://purl.uniprot.org/uniprot/A0A8J8YKJ7|||http://purl.uniprot.org/uniprot/G7P004 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9541:TCTN3 ^@ http://purl.uniprot.org/uniprot/Q4R9E0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tectonic family.|||Membrane|||Part of the tectonic-like complex (also named B9 complex).|||Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. May be involved in apoptosis regulation (By similarity). Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway (By similarity). http://togogenome.org/gene/9541:ACTR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY73 ^@ Similarity ^@ Belongs to the actin family. ARP3 subfamily. http://togogenome.org/gene/9541:FAM187A ^@ http://purl.uniprot.org/uniprot/A0A8J8YDG6|||http://purl.uniprot.org/uniprot/G7PV11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM187 family.|||Membrane http://togogenome.org/gene/9541:UBE2D3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7V3|||http://purl.uniprot.org/uniprot/A0A2K5W840|||http://purl.uniprot.org/uniprot/I7GL84|||http://purl.uniprot.org/uniprot/Q4R5N4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (By similarity).|||Belongs to the ubiquitin-conjugating enzyme family.|||Cell membrane|||Endosome membrane|||Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex; when Cullin is neddylated, the interaction between the E2 and the SCF complex is strengthened. Interacts with DAPK3. Interacts with BRCA1; the DNA damage checkpoint promotes the association with BRCA1 after ionizing radiation. Interacts non-covalently with ubiquitin. Interacts with E3 ubiquitin-protein ligase CBLC. Interacts with UBTD1 (By similarity). Interacts with RIGI and RNF135; involved in RIGI ubiquitination and activation (By similarity).|||Phosphorylated by AURKB. http://togogenome.org/gene/9541:GPR89A ^@ http://purl.uniprot.org/uniprot/A0A2K5U8Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Golgi pH regulator (TC 1.A.38) family.|||Membrane http://togogenome.org/gene/9541:SLC20A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UD48|||http://purl.uniprot.org/uniprot/A0A7N9DB23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. http://togogenome.org/gene/9541:AMD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UT80|||http://purl.uniprot.org/uniprot/G7P3N5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic AdoMetDC family.|||Binds 1 pyruvoyl group covalently per subunit.|||Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.|||Heterotetramer of two alpha and two beta chains. http://togogenome.org/gene/9541:TACR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X9Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:AFF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQ96 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/9541:LOC102129503 ^@ http://purl.uniprot.org/uniprot/G7PCD9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:NRF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBZ1|||http://purl.uniprot.org/uniprot/A0A2K5VC21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRF1/Ewg family.|||Nucleus http://togogenome.org/gene/9541:WDR24 ^@ http://purl.uniprot.org/uniprot/A0A2K5UV49 ^@ Similarity ^@ Belongs to the WD repeat WDR24 family. http://togogenome.org/gene/9541:SUCLA2 ^@ http://purl.uniprot.org/uniprot/Q4R517 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.|||Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP. Interacts with ALAS2 (By similarity).|||Mitochondrion http://togogenome.org/gene/9541:SCUBE3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UK84|||http://purl.uniprot.org/uniprot/A0A2K5VBW0|||http://purl.uniprot.org/uniprot/A0A7N9DF80 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:HTATSF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VP69 ^@ Similarity ^@ Belongs to the HTATSF1 family. http://togogenome.org/gene/9541:CACNG4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. http://togogenome.org/gene/9541:LOC102117900 ^@ http://purl.uniprot.org/uniprot/D3GG13 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. http://togogenome.org/gene/9541:TMED9 ^@ http://purl.uniprot.org/uniprot/I7GHY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:LOC102138114 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQK2 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9541:HDAC11 ^@ http://purl.uniprot.org/uniprot/Q9GKU5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone deacetylase family.|||Interacts with HDAC6.|||Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). http://togogenome.org/gene/9541:KBTBD8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WA77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KBTBD8 family.|||Golgi apparatus|||spindle http://togogenome.org/gene/9541:MAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6F5|||http://purl.uniprot.org/uniprot/A0A2K5W6J2|||http://purl.uniprot.org/uniprot/A0A2K5W6L6|||http://purl.uniprot.org/uniprot/A0A7N9DEN1|||http://purl.uniprot.org/uniprot/G7PLB5 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:LOC102117168 ^@ http://purl.uniprot.org/uniprot/G7PS82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:AK5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VF31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/9541:FGD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBT3 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:BACE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Membrane|||Secreted http://togogenome.org/gene/9541:ATP6V1B1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XV71|||http://purl.uniprot.org/uniprot/G7PMF8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ATPase alpha/beta chains family.|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits. http://togogenome.org/gene/9541:SUOX ^@ http://purl.uniprot.org/uniprot/A0A2K5WYK3|||http://purl.uniprot.org/uniprot/Q60HD0 ^@ Cofactor|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.|||Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.|||Homodimer.|||Mitochondrion intermembrane space http://togogenome.org/gene/9541:SLC13A5 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y478|||http://purl.uniprot.org/uniprot/G7PTE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9541:SIGIRR ^@ http://purl.uniprot.org/uniprot/A0A2K5WX31 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9541:SETDB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZX6 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/9541:GPKOW ^@ http://purl.uniprot.org/uniprot/A0A8J8XSZ1|||http://purl.uniprot.org/uniprot/G7Q2P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MOS2 family.|||Nucleus http://togogenome.org/gene/9541:GOLGA5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVH1 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.|||Membrane http://togogenome.org/gene/9541:TAF11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAH3|||http://purl.uniprot.org/uniprot/G7P2U5 ^@ Similarity ^@ Belongs to the TAF11 family. http://togogenome.org/gene/9541:TOP2A ^@ http://purl.uniprot.org/uniprot/A0A2K5TYT1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase family.|||Homodimer.|||Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9541:EFHC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ25 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9541:SLC30A9 ^@ http://purl.uniprot.org/uniprot/G7P5H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Cytoplasmic vesicle|||Endoplasmic reticulum|||Membrane|||Nucleus|||Vesicle http://togogenome.org/gene/9541:ATP2B2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4V9|||http://purl.uniprot.org/uniprot/A0A2K5U4W6|||http://purl.uniprot.org/uniprot/A0A2K5U4Y2|||http://purl.uniprot.org/uniprot/A0A2K5U4Y5|||http://purl.uniprot.org/uniprot/A0A2K5U535 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:AZIN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZB4|||http://purl.uniprot.org/uniprot/I7GIW1|||http://purl.uniprot.org/uniprot/I7GJ97|||http://purl.uniprot.org/uniprot/I7GMJ8 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9541:YWHAE ^@ http://purl.uniprot.org/uniprot/A0A2K5WWZ6|||http://purl.uniprot.org/uniprot/A0A2K5WX26|||http://purl.uniprot.org/uniprot/Q4R4J3 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9541:LOC102128132 ^@ http://purl.uniprot.org/uniprot/A0A8J8YPI1|||http://purl.uniprot.org/uniprot/G7P1L2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9541:LOC102126880 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102124177 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6K9|||http://purl.uniprot.org/uniprot/A0A2K5VLR8 ^@ Function|||Similarity ^@ Belongs to the SSX family.|||Could act as a modulator of transcription. http://togogenome.org/gene/9541:TUBGCP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9541:BPI ^@ http://purl.uniprot.org/uniprot/A0A2K5VAG2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Cytoplasmic granule membrane|||Membrane|||Monomer. Homodimer; disulfide-linked.|||Secreted|||The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.|||The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.|||The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. http://togogenome.org/gene/9541:ACAT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9T2 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9541:ADAMTS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W612 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:PDHB ^@ http://purl.uniprot.org/uniprot/A0A2K5V5K5 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/9541:ACER2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0D7|||http://purl.uniprot.org/uniprot/G7PSA1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:RPS6KB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWA4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9541:PRPS1L1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CH96 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/9541:CEBPZ ^@ http://purl.uniprot.org/uniprot/A0A2K5W129 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/9541:ORC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSF3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC1 family.|||Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Nucleus http://togogenome.org/gene/9541:LOC102122694 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1V6 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9541:ACKR4 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5K1|||http://purl.uniprot.org/uniprot/G7NXZ5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:USP22 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8G9 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9541:GGA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLK7|||http://purl.uniprot.org/uniprot/A0A2K5VLN3|||http://purl.uniprot.org/uniprot/A0A2K5VLX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:DNAJA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTB4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:UBQLN2 ^@ http://purl.uniprot.org/uniprot/G8F2K6 ^@ Subcellular Location Annotation ^@ Membrane|||Nucleus|||autophagosome http://togogenome.org/gene/9541:PRKCG ^@ http://purl.uniprot.org/uniprot/Q4R4U2 ^@ Activity Regulation|||Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autophosphorylation on Thr-674 appears to regulate motor functions of junctophilins, JPH3 and JPH4.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.|||Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress. Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock.|||Cell membrane|||Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-514 (activation loop of the kinase domain), Thr-655 (turn motif) and Thr-674 (hydrophobic region), need to be phosphorylated for its full activation.|||Cytoplasm|||Interacts with CDCP1 and GRIA4. Interacts with TP53INP1 and p53/TP53. Interacts with BMAL1.|||Ubiquitinated.|||dendrite|||perinuclear region|||synaptosome http://togogenome.org/gene/9541:GFRA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1I7 ^@ Similarity ^@ Belongs to the GDNFR family. http://togogenome.org/gene/9541:SRP9 ^@ http://purl.uniprot.org/uniprot/G8F5S9|||http://purl.uniprot.org/uniprot/Q4R6I6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP9 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (By similarity). The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity).|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm|||Heterodimer with SRP14; binds RNA as heterodimer (By similarity). Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity). http://togogenome.org/gene/9541:MSANTD3 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y9T4|||http://purl.uniprot.org/uniprot/G7PRU2 ^@ Similarity ^@ Belongs to the MSANTD3 family. http://togogenome.org/gene/9541:EHD2 ^@ http://purl.uniprot.org/uniprot/Q4R9B5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9541:BCL9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BCL9 family.|||Nucleus http://togogenome.org/gene/9541:LOC102117303 ^@ http://purl.uniprot.org/uniprot/A0A7N9CI04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRB/QCR7 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:CCDC181 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVE0|||http://purl.uniprot.org/uniprot/Q4R6Q9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC181 family.|||Homodimer. Interacts with HOOK1. Interacts with HOOK2. Interacts with HOOK3.|||Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.|||cytoskeleton|||flagellum http://togogenome.org/gene/9541:LOC107127356 ^@ http://purl.uniprot.org/uniprot/G7PQ69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:POLR2F ^@ http://purl.uniprot.org/uniprot/A0A2K5U2B7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.|||Nucleus http://togogenome.org/gene/9541:TMEM41B ^@ http://purl.uniprot.org/uniprot/A0A2K5W756 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/9541:YIPF6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XVC8|||http://purl.uniprot.org/uniprot/G7Q2X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/9541:S100A10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQE4|||http://purl.uniprot.org/uniprot/G7NTU2 ^@ Function ^@ Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. http://togogenome.org/gene/9541:KAT6A ^@ http://purl.uniprot.org/uniprot/A0A2K5X204 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9541:HUS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6G8 ^@ Similarity ^@ Belongs to the HUS1 family. http://togogenome.org/gene/9541:AP1B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0N0|||http://purl.uniprot.org/uniprot/A0A2K5X0Q6|||http://purl.uniprot.org/uniprot/A0A2K5X187 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9541:GJA1 ^@ http://purl.uniprot.org/uniprot/Q4R4S7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with SGSM3 (By similarity). Interacts with RIC1/CIP150 (By similarity). Interacts with CNST and CSNK1D (By similarity). Interacts (via C-terminus) with TJP1. Interacts (via C-terminus) with SRC (via SH3 domain). Interacts (not ubiquitinated) with UBQLN4 (via UBA domain) (By similarity). Interacts with NOV. Interacts with TMEM65 (By similarity).|||Acetylated in the developing cortex; leading to delocalization from the cell membrane.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Endoplasmic reticulum|||Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity).|||Phosphorylation at Ser-325, Ser-328 and Ser-330 by CK1 modulates gap junction assembly. Phosphorylated at Ser-368 by PRKCG; phosphorylation induces disassembly of gap junction plaques and inhibition of gap junction activity. Phosphorylation at Ser-368 by PRKCD triggers its internalization into small vesicles leading to proteasome-mediated degradation (By similarity).|||S-nitrosylation at Cys-271 is enriched at the muscle endothelial gap junction in arteries, it augments channel permeability and may regulate of smooth muscle cell to endothelial cell communication.|||Sumoylated with SUMO1, SUMO2 and SUMO3, which may regulate the level of functional Cx43 gap junctions at the plasma membrane. May be desumoylated by SENP1 or SENP2 (By similarity).|||gap junction http://togogenome.org/gene/9541:THADA ^@ http://purl.uniprot.org/uniprot/A0A2K5UJK6 ^@ Similarity ^@ Belongs to the THADA family. http://togogenome.org/gene/9541:MRE11 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3W9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MRE11/RAD32 family.|||Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.|||Nucleus http://togogenome.org/gene/9541:BCAR3 ^@ http://purl.uniprot.org/uniprot/Q4R8R1 ^@ Caution|||Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (By similarity). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (By similarity). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity. May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (By similarity). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling. Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA. Positively regulates integrin-induced tyrosine phosphorylation of BCAR1. Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (By similarity).|||Cytoplasm|||Part of a complex comprised of PTPRA, BCAR1, BCAR3 (via SH2 domain) and SRC; the formation of the complex is dependent on integrin mediated-tyrosine phosphorylation of PTPRA (By similarity). Within the complex, interacts (via SH2 domain) with PTPRA (when phosphorylated on 'Tyr-798') (By similarity). Interacts (via Ras-GEF domain) with BCAR1 (By similarity). Interacts (via Ras-GEF domain) with NEDD9 (By similarity). Interacts with PTK2/FAK1 (By similarity). Interacts with PTPN1. Interacts (via SH2 domain) with EGFR (when tyrosine-phosphorylated) (By similarity).|||Phosphorylated on tyrosine residues.|||The Ras-GEF domain appears to adopt a closed conformation rendering it incapable of carrying out canonical exchange factor function, this closed conformation is probably required for interaction with BCAR1.|||The SH2 domain mediates interaction with tyrosine-phosphorylated proteins (By similarity). However, not involved in the binding to phosphorylated BCAR1 (By similarity). Required for cell cycle progression in response to INS/insulin (By similarity). Required for regulation of EGF-induced DNA synthesis (By similarity).|||The guanine nucleotide exchange factor (GEF) activity is controversial. One study showed GEF activity towards RALA, RAP1A and RRAS (By similarity). However, in another study, a construct containing only the Ras-GEF domain lacks GEF activity towards RAP1 (By similarity).|||focal adhesion http://togogenome.org/gene/9541:UNC5D ^@ http://purl.uniprot.org/uniprot/A0A2K5X484|||http://purl.uniprot.org/uniprot/A0A2K5X486 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9541:CREB5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR28|||http://purl.uniprot.org/uniprot/A0A2K5TR43 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.|||Binds to the cAMP response element and activates transcription.|||Nucleus http://togogenome.org/gene/9541:IDH3G ^@ http://purl.uniprot.org/uniprot/A0A2K5WRH7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/9541:CAPN7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TW91 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9541:RAD17 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTI4|||http://purl.uniprot.org/uniprot/A0A2K5UTK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad17/RAD24 family.|||Nucleus http://togogenome.org/gene/9541:MTURN ^@ http://purl.uniprot.org/uniprot/A0A2K5WK10|||http://purl.uniprot.org/uniprot/A0A7N9C985 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MTURN family.|||Cytoplasm http://togogenome.org/gene/9541:ACER1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Membrane http://togogenome.org/gene/9541:TGIF2LX ^@ http://purl.uniprot.org/uniprot/Q8MID8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/TGIF homeobox family.|||May have a transcription role in testis.|||Nucleus http://togogenome.org/gene/9541:SLC16A12 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEE5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102117847 ^@ http://purl.uniprot.org/uniprot/Q28476 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:C4BPA ^@ http://purl.uniprot.org/uniprot/A0A2K5UC71 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC102128005 ^@ http://purl.uniprot.org/uniprot/A0A2K5V204|||http://purl.uniprot.org/uniprot/G7PIC9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:LOC101926276 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBJ9|||http://purl.uniprot.org/uniprot/G7NTV6|||http://purl.uniprot.org/uniprot/G8F324 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:SLC17A5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPS7|||http://purl.uniprot.org/uniprot/A0A2K5VPV6|||http://purl.uniprot.org/uniprot/G7P3G3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:OTUB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6Q4|||http://purl.uniprot.org/uniprot/A0A2K5U6T3|||http://purl.uniprot.org/uniprot/Q4R5L0 ^@ Similarity ^@ Belongs to the peptidase C65 family. http://togogenome.org/gene/9541:SPARC ^@ http://purl.uniprot.org/uniprot/A0A8J8XD95|||http://purl.uniprot.org/uniprot/G7P8R2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|||Belongs to the SPARC family.|||Membrane|||basement membrane http://togogenome.org/gene/9541:PRPS1 ^@ http://purl.uniprot.org/uniprot/Q4R4U3 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Activated by magnesium and inorganic phosphate.|||Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity). http://togogenome.org/gene/9541:ACAT1 ^@ http://purl.uniprot.org/uniprot/Q8HXY6 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by potassium ions, but not sodium ions.|||Belongs to the thiolase-like superfamily. Thiolase family.|||Homotetramer.|||Mitochondrion|||Succinylation at Lys-268, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5 (By similarity).|||This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. http://togogenome.org/gene/9541:SLC35A3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CEN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Membrane http://togogenome.org/gene/9541:SMAD7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VD29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:MPPE1 ^@ http://purl.uniprot.org/uniprot/Q9GMS6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallophosphoesterase superfamily. MPPE1 family.|||Binds 2 manganese ions per subunit.|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Interacts with GPI-anchor proteins. Interacts with TMED10 (By similarity).|||Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins (By similarity).|||cis-Golgi network membrane http://togogenome.org/gene/9541:PPP2R3C ^@ http://purl.uniprot.org/uniprot/A0A8J8YFJ9|||http://purl.uniprot.org/uniprot/G7PA30 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:SLC39A7 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y167|||http://purl.uniprot.org/uniprot/G7P2S2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SKAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPA7|||http://purl.uniprot.org/uniprot/G7PU68 ^@ Similarity ^@ Belongs to the SKAP family. http://togogenome.org/gene/9541:EIF2AK1 ^@ http://purl.uniprot.org/uniprot/Q4R8E0 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by autophosphorylation; phosphorylated predominantly on serine and threonine residues, but also on tyrosine residues. Autophosphorylation at Thr-488 is required for kinase activation. The active autophosphorylated form apparently is largely refractory to cellular heme fluctuations.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.|||Cytoplasm|||In normal conditions, the protein kinase activity is inhibited; inhibition is relieved by various stress conditions (By similarity). Inhibited by heme: in presence of heme, forms a disulfide-linked inactive homodimer (By similarity). Heme depletion relieves inhibition and stimulates kinase activity by autophosphorylation. Inhibited by the heme metabolites biliverdin and bilirubin. Induced by oxidative stress generated by arsenite treatment. Binding of nitric oxide (NO) to the heme iron in the N-terminal heme-binding domain activates the kinase activity, while binding of carbon monoxide (CO) suppresses kinase activity (By similarity). Protein kinase activity is also activated upon binding to the processed form of DELE1 (S-DELE1): interaction with S-DELE1 takes place in response to mitochondrial stress and triggers the integrated stress response (ISR) (By similarity).|||Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming. Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (By similarity). Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (By similarity).|||Synthesized in an inactive form that binds to the N-terminal domain of CDC37. Has to be associated with a multiprotein complex containing Hsp90, CDC37 and PPP5C for maturation and activation by autophosphorylation. The phosphatase PPP5C modulates this activation (By similarity). Homodimer; homodimerizes in presence of heme, forming a disulfide-linked inactive homodimer (By similarity). Interacts with DELE1; binds to the processed form of DELE1 (S-DELE1) in response to mitochondrial stress, leading to activate its protein kinase activity and trigger the integrated stress response (ISR) (By similarity). http://togogenome.org/gene/9541:SLC18A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVB8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ALG6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.|||Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:GMFG ^@ http://purl.uniprot.org/uniprot/A0A2K5W3N6|||http://purl.uniprot.org/uniprot/A0A2K5W3U4 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/9541:EWSR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSB9|||http://purl.uniprot.org/uniprot/A0A2K5WSC3|||http://purl.uniprot.org/uniprot/Q4R3Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/9541:MAPK8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL44|||http://purl.uniprot.org/uniprot/A0A2K5WLC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/9541:LPIN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPD9 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/9541:DECR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJJ4 ^@ Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.|||Monomer, dimer and oligomer. http://togogenome.org/gene/9541:SMC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC4 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9541:FOXP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJF8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CDKN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WR43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family.|||May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.|||perinuclear region http://togogenome.org/gene/9541:AIF1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XFL1|||http://purl.uniprot.org/uniprot/G7P4P6 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/9541:MYG1 ^@ http://purl.uniprot.org/uniprot/I7G3B2 ^@ Similarity ^@ Belongs to the MYG1 family. http://togogenome.org/gene/9541:CDC42BPB ^@ http://purl.uniprot.org/uniprot/A0A2K5VKE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.|||Cytoplasm|||lamellipodium http://togogenome.org/gene/9541:LOC102134628 ^@ http://purl.uniprot.org/uniprot/A0A2K5WS51 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/9541:TNS4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/9541:KCTD15 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFG5 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:CEP170 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0N4|||http://purl.uniprot.org/uniprot/A0A2K5U0P2 ^@ Similarity ^@ Belongs to the CEP170 family. http://togogenome.org/gene/9541:RHBG ^@ http://purl.uniprot.org/uniprot/A0A2K5WZK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9541:POLR2C ^@ http://purl.uniprot.org/uniprot/A0A2K5UGS4|||http://purl.uniprot.org/uniprot/G7Q181 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/9541:PLA2G1B ^@ http://purl.uniprot.org/uniprot/A0A7N9IEX0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9541:DSCC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAB7 ^@ Similarity ^@ Belongs to the DCC1 family. http://togogenome.org/gene/9541:CXCL10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9541:LOC102137997 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN85 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:STRN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPH5|||http://purl.uniprot.org/uniprot/A0A2K5UPH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat striatin family.|||Membrane http://togogenome.org/gene/9541:MSI2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WC18 ^@ Similarity ^@ Belongs to the Musashi family. http://togogenome.org/gene/9541:SFXN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9541:LOC102118223 ^@ http://purl.uniprot.org/uniprot/A0A7N9CZJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:DEFB113 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0I2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:LPO ^@ http://purl.uniprot.org/uniprot/A0A2K5WIC2 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Secreted http://togogenome.org/gene/9541:GUCY2F ^@ http://purl.uniprot.org/uniprot/A0A2K5VU62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/9541:PLCB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNX4|||http://purl.uniprot.org/uniprot/A0A2K5TNX6|||http://purl.uniprot.org/uniprot/A0A2K5TNY0|||http://purl.uniprot.org/uniprot/A0A2K5TNZ1 ^@ Function ^@ The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/9541:PCOLCE ^@ http://purl.uniprot.org/uniprot/A0A2K5WMV4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:TBXAS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UH73|||http://purl.uniprot.org/uniprot/Q2PG45 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome P450 family.|||Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.|||Endoplasmic reticulum membrane|||It is uncertain whether Met-1 is the initiator. An alternative upstream Met is found in primates, but not in other mammalians.|||Monomer. http://togogenome.org/gene/9541:DOP1A ^@ http://purl.uniprot.org/uniprot/A0A2K5V0M3|||http://purl.uniprot.org/uniprot/A0A2K5V0Q6|||http://purl.uniprot.org/uniprot/A0A2K5V0S2 ^@ Similarity ^@ Belongs to the dopey family. http://togogenome.org/gene/9541:IL22 ^@ http://purl.uniprot.org/uniprot/A0A8J8XHW8|||http://purl.uniprot.org/uniprot/G7PHZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Secreted http://togogenome.org/gene/9541:LOC102123517 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CHRNA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:LOC102137168 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5C7 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/9541:DDX18 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDJ7 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. http://togogenome.org/gene/9541:LOC102127229 ^@ http://purl.uniprot.org/uniprot/P67992|||http://purl.uniprot.org/uniprot/Q25CR9 ^@ Disease Annotation|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prion family.|||Cell membrane|||Contains an N-terminal region composed of octamer repeats. At low copper concentrations, the sidechains of His residues from three or four repeats contribute to the binding of a single copper ion. Alternatively, a copper ion can be bound by interaction with the sidechain and backbone amide nitrogen of a single His residue. The observed copper binding stoichiometry suggests that two repeat regions cooperate to stabilize the binding of a single copper ion. At higher copper concentrations, each octamer can bind one copper ion by interactions with the His sidechain and Gly backbone atoms. A mixture of binding types may occur, especially in the case of octamer repeat expansion. Copper binding may stabilize the conformation of this region and may promote oligomerization.|||Golgi apparatus|||Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).|||Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.|||Membrane|||Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization. Interacts with GRB2, APP, ERI3/PRNPIP and SYN1. Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement. Interacts with KIAA1191.|||PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.|||The normal, monomeric form has a mainly alpha-helical structure. The disease-associated, protease-resistant form forms amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Disease mutations may favor intermolecular contacts via short beta strands, and may thereby trigger oligomerization. http://togogenome.org/gene/9541:TOP2B ^@ http://purl.uniprot.org/uniprot/A0A2K5VKA0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase family.|||Homodimer.|||Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9541:CABYR ^@ http://purl.uniprot.org/uniprot/Q4R3X7 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with FSCB.|||May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. May bind calcium in vitro (By similarity).|||Phosphorylated on tyrosine residues during in vitro capacitation. Dephosphorylation affects its ability to bind calcium (By similarity).|||cytoskeleton|||flagellum http://togogenome.org/gene/9541:PIAS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXI3 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/9541:PMM1 ^@ http://purl.uniprot.org/uniprot/Q4R4J4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9541:AOC2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2F1|||http://purl.uniprot.org/uniprot/G7PUW5 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/9541:ACMSD ^@ http://purl.uniprot.org/uniprot/A0A2K5U9N6|||http://purl.uniprot.org/uniprot/A0A7N9CFZ9|||http://purl.uniprot.org/uniprot/A0A7N9IB17|||http://purl.uniprot.org/uniprot/A0A8J8YBQ4|||http://purl.uniprot.org/uniprot/G7PN37 ^@ Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.|||Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.|||Monomer. http://togogenome.org/gene/9541:GARIN6 ^@ http://purl.uniprot.org/uniprot/Q4R323 ^@ Similarity ^@ Belongs to the GARIN family. http://togogenome.org/gene/9541:DPYS ^@ http://purl.uniprot.org/uniprot/A0A2K5W5E6 ^@ PTM|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Carbamylation allows a single lysine to coordinate two divalent metal cations. http://togogenome.org/gene/9541:CPNE8 ^@ http://purl.uniprot.org/uniprot/A0A8J8YL94|||http://purl.uniprot.org/uniprot/G7PHL3|||http://purl.uniprot.org/uniprot/Q4R7A5 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9541:DDRGK1 ^@ http://purl.uniprot.org/uniprot/G7PGU8 ^@ Similarity ^@ Belongs to the DDRGK1 family. http://togogenome.org/gene/9541:NUTF2 ^@ http://purl.uniprot.org/uniprot/I7G6Q2 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/9541:BLMH ^@ http://purl.uniprot.org/uniprot/A0A2K5TUG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Cytoplasm http://togogenome.org/gene/9541:IFNGR1 ^@ http://purl.uniprot.org/uniprot/G7P327|||http://purl.uniprot.org/uniprot/I7GMW5 ^@ Similarity ^@ Belongs to the type II cytokine receptor family. http://togogenome.org/gene/9541:ZSCAN4 ^@ http://purl.uniprot.org/uniprot/G7PZA1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SLC48A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WP10 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HRG family.|||Endosome membrane|||Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9541:CRYGS ^@ http://purl.uniprot.org/uniprot/A0A2K5TLY3|||http://purl.uniprot.org/uniprot/A0A8J8XT43 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9541:PBX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKT8|||http://purl.uniprot.org/uniprot/A0A2K5UKW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/9541:PELI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VC28|||http://purl.uniprot.org/uniprot/G7PMB5 ^@ Function|||Similarity ^@ Belongs to the pellino family.|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. http://togogenome.org/gene/9541:CNOT7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJS4|||http://purl.uniprot.org/uniprot/A0A2K5WJX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/9541:DOCK7 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5M7|||http://purl.uniprot.org/uniprot/A0A2K5V5X2|||http://purl.uniprot.org/uniprot/A0A2K5V5Y4|||http://purl.uniprot.org/uniprot/A0A2K5V671 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9541:RALGPS2 ^@ http://purl.uniprot.org/uniprot/Q4R7W3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Cytoplasm|||Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion.|||Interacts with the SH3 domains of GRB2 and PLCG1. Interacts with RALA. http://togogenome.org/gene/9541:RSRP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBG8|||http://purl.uniprot.org/uniprot/Q4R626 ^@ Similarity ^@ Belongs to the RSRP family. http://togogenome.org/gene/9541:DEFB121 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y8S5|||http://purl.uniprot.org/uniprot/G7PGP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:C12H2orf76 ^@ http://purl.uniprot.org/uniprot/A0A2K5TY70|||http://purl.uniprot.org/uniprot/G7PN51 ^@ Similarity ^@ Belongs to the UPF0538 family. http://togogenome.org/gene/9541:IL1R1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFG4|||http://purl.uniprot.org/uniprot/A0A7N9CMI5 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9541:DLAT ^@ http://purl.uniprot.org/uniprot/A0A2K5UNA0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 2 lipoyl cofactors covalently.|||Mitochondrion matrix|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/9541:SYN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0P4 ^@ Similarity ^@ Belongs to the synapsin family. http://togogenome.org/gene/9541:LOC102120369 ^@ http://purl.uniprot.org/uniprot/A0A2K5V493|||http://purl.uniprot.org/uniprot/G7PKT5 ^@ Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/9541:ARL5B ^@ http://purl.uniprot.org/uniprot/A0A7N9CLT2 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9541:ORC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VX13 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC3 family.|||Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.|||Nucleus http://togogenome.org/gene/9541:DGKE ^@ http://purl.uniprot.org/uniprot/A0A7N9CLX3 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9541:TUBGCP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2X5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9541:PRKAA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNP6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/9541:SH3RF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X499 ^@ Similarity ^@ Belongs to the SH3RF family. http://togogenome.org/gene/9541:MVD ^@ http://purl.uniprot.org/uniprot/A0A2K5X8J4 ^@ Function|||Similarity ^@ Belongs to the diphosphomevalonate decarboxylase family.|||Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. http://togogenome.org/gene/9541:TINAG ^@ http://purl.uniprot.org/uniprot/A0A2K5VFX9 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9541:ATP5IF1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQQ0|||http://purl.uniprot.org/uniprot/G7NWV6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase inhibitor family.|||Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.|||Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.|||Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.|||Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.|||Mitochondrion http://togogenome.org/gene/9541:TTC9C ^@ http://purl.uniprot.org/uniprot/Q9BGT1 ^@ Similarity ^@ Belongs to the TTC9 family. http://togogenome.org/gene/9541:PHF19 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMN9|||http://purl.uniprot.org/uniprot/G7PRJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/9541:USP15 ^@ http://purl.uniprot.org/uniprot/A0A2K5TK24|||http://purl.uniprot.org/uniprot/A0A2K5TK29|||http://purl.uniprot.org/uniprot/A0A8J8YA73|||http://purl.uniprot.org/uniprot/G7PIX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus http://togogenome.org/gene/9541:ARL5A ^@ http://purl.uniprot.org/uniprot/A0A2K5W621|||http://purl.uniprot.org/uniprot/G7PKK8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9541:CD59 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4S1|||http://purl.uniprot.org/uniprot/G7PQF7|||http://purl.uniprot.org/uniprot/Q8SQ46 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Interacts with T-cell surface antigen CD2.|||Membrane|||N- and O-glycosylated.|||Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity). http://togogenome.org/gene/9541:OCM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1N3 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/9541:MOXD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5J9 ^@ Similarity ^@ Belongs to the copper type II ascorbate-dependent monooxygenase family. http://togogenome.org/gene/9541:TNFAIP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQH9|||http://purl.uniprot.org/uniprot/G7PTW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BACURD family.|||Cell membrane http://togogenome.org/gene/9541:TAT ^@ http://purl.uniprot.org/uniprot/A0A8J8XI10|||http://purl.uniprot.org/uniprot/G7Q1K1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. http://togogenome.org/gene/9541:PRSS37 ^@ http://purl.uniprot.org/uniprot/Q4R7Y7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Although related to peptidase S1 family, lacks the conserved active Ser residue in position 192 which is replaced by an Ala, suggesting that it has no protease activity. Lacks also metal binding sites Glu in position 67 which is replaced by Asn and Asn in position 69 which is replaced by Lys.|||Belongs to the peptidase S1 family.|||Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system.|||Secreted|||acrosome http://togogenome.org/gene/9541:STING1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TV20|||http://purl.uniprot.org/uniprot/A0A2R3XZA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STING family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||Mitochondrion outer membrane|||autophagosome membrane|||perinuclear region http://togogenome.org/gene/9541:SYT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAC0|||http://purl.uniprot.org/uniprot/G7PIJ5|||http://purl.uniprot.org/uniprot/Q60HC0 ^@ Cofactor|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (By similarity).|||Cytoplasm|||Glycosylated.|||Homotetramer (Probable). Interacts with SCAMP5 (By similarity). Interacts with STON2 (By similarity). Forms a complex with SV2B, syntaxin 1 and SNAP25 (By similarity). Interacts with SV2A, SV2B and SV2C (By similarity). Interacts with RIMS1 (By similarity). Interacts with PRRT2 (By similarity). Interacts with DNAJC5 in a phosphorylation-dependent manner (By similarity). Interacts (via N-terminus) with RAB3A (By similarity). Interacts with SYT12 (By similarity). Interacts with calmodulin (By similarity).|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||Membrane|||The first C2 domain mediates Ca(2+)-dependent phospholipid binding.|||The second C2 domain mediates interaction with SV2A and probably with STN2.|||chromaffin granule membrane|||secretory vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/9541:SNRPE ^@ http://purl.uniprot.org/uniprot/A0A2K5WYY9|||http://purl.uniprot.org/uniprot/G7NVE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/9541:FGFR1OP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDJ4 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/9541:SMARCD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WM95 ^@ Similarity ^@ Belongs to the SMARCD family. http://togogenome.org/gene/9541:SLC25A6 ^@ http://purl.uniprot.org/uniprot/I7GNQ6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9541:NR1I2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:MAFA-B ^@ http://purl.uniprot.org/uniprot/E5FNB1 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9541:TNFSF10 ^@ http://purl.uniprot.org/uniprot/I7GIW0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Homotrimer.|||Membrane|||Secreted http://togogenome.org/gene/9541:RPL32 ^@ http://purl.uniprot.org/uniprot/G7P6U9|||http://purl.uniprot.org/uniprot/Q76KA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL32 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm http://togogenome.org/gene/9541:UNC5C ^@ http://purl.uniprot.org/uniprot/A0A8J8YQ14|||http://purl.uniprot.org/uniprot/G7P5Y1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9541:DZIP1L ^@ http://purl.uniprot.org/uniprot/A0A2K5VVH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DZIP C2H2-type zinc-finger protein family.|||centriole|||cilium basal body http://togogenome.org/gene/9541:CERS5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VF92 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9541:PPP3R1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWF8|||http://purl.uniprot.org/uniprot/A0A7N9D4V0 ^@ Similarity ^@ Belongs to the calcineurin regulatory subunit family. http://togogenome.org/gene/9541:BLK ^@ http://purl.uniprot.org/uniprot/A0A2K5WHE1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9541:IDNK ^@ http://purl.uniprot.org/uniprot/A0A2K5UJQ4 ^@ Similarity ^@ Belongs to the gluconokinase GntK/GntV family. http://togogenome.org/gene/9541:ESYT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7X0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the extended synaptotagmin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:RHOXF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TM98|||http://purl.uniprot.org/uniprot/G7Q3L2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:APOBEC3H ^@ http://purl.uniprot.org/uniprot/A0A2K5UY49 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:LAMP5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XGG8|||http://purl.uniprot.org/uniprot/G7PGY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane http://togogenome.org/gene/9541:IMP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UE45|||http://purl.uniprot.org/uniprot/G8F2V1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/9541:ANK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2U5|||http://purl.uniprot.org/uniprot/A0A2K5V2U8 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9541:NFKB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTZ1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:ERCC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RAD3/XPD subfamily.|||Nucleus http://togogenome.org/gene/9541:LOC102144252 ^@ http://purl.uniprot.org/uniprot/A0A2K5W993|||http://purl.uniprot.org/uniprot/A0A2K5W9F1|||http://purl.uniprot.org/uniprot/G7PFF2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:LOC102121480 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGZ9 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9541:IMPA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UR28 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9541:MKI67 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4R7|||http://purl.uniprot.org/uniprot/A0A2K5W4U2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:IL21 ^@ http://purl.uniprot.org/uniprot/A0A2K5UL71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/9541:EEF1A1 ^@ http://purl.uniprot.org/uniprot/Q4R5K0 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/9541:LOC102115550 ^@ http://purl.uniprot.org/uniprot/A0A2K5VA77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX16 family.|||Membrane http://togogenome.org/gene/9541:RNF43 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZNRF3 family.|||Cell membrane http://togogenome.org/gene/9541:PADI4 ^@ http://purl.uniprot.org/uniprot/A0A2K5USI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9541:SNX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome|||Endosome|||phagosome http://togogenome.org/gene/9541:PEX12 ^@ http://purl.uniprot.org/uniprot/I7G2Z0 ^@ Function|||Similarity ^@ Belongs to the pex2/pex10/pex12 family.|||Required for protein import into peroxisomes. http://togogenome.org/gene/9541:PPFIBP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYZ6|||http://purl.uniprot.org/uniprot/A0A2K5WZ00|||http://purl.uniprot.org/uniprot/A0A2K5WZ74 ^@ Similarity ^@ Belongs to the liprin family. Liprin-beta subfamily. http://togogenome.org/gene/9541:EIF3D ^@ http://purl.uniprot.org/uniprot/A0A2K5X7Q7 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit D family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Cytoplasm|||Phosphorylated upon DNA damage, probably by ATM or ATR.|||The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.|||mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. http://togogenome.org/gene/9541:EEF2K ^@ http://purl.uniprot.org/uniprot/A0A8J8XP58|||http://purl.uniprot.org/uniprot/G7Q0P5 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. Alpha-type protein kinase family.|||Monomer or homodimer.|||Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent. http://togogenome.org/gene/9541:LPAR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSP4|||http://purl.uniprot.org/uniprot/G7PX21|||http://purl.uniprot.org/uniprot/Q95KH4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cell surface|||Interacts with SLC9A3R2/NHERF2, MAGI3 and PLCB3. Interacts with RALA and GRK2 (By similarity).|||Membrane|||Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation (By similarity). http://togogenome.org/gene/9541:SYT2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YJ11|||http://purl.uniprot.org/uniprot/G7NWD9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||Membrane|||chromaffin granule membrane|||synaptic vesicle membrane http://togogenome.org/gene/9541:KIF23 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVJ5|||http://purl.uniprot.org/uniprot/A0A2K5VVL4|||http://purl.uniprot.org/uniprot/A0A2K5VVM4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:LOC102146887 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystatin family.|||Secreted http://togogenome.org/gene/9541:METTL14 ^@ http://purl.uniprot.org/uniprot/O02663 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Microsome membrane|||UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on C18, C19, and C21 steroids, bile acids, and several xenobiotics including eugenol, 1-naphthol, and p-nitrophenol. http://togogenome.org/gene/9541:CLGN ^@ http://purl.uniprot.org/uniprot/A0A8J8YPA9|||http://purl.uniprot.org/uniprot/G7P6B4 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/9541:ZFP30 ^@ http://purl.uniprot.org/uniprot/Q9BE27 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:BEX4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHM0|||http://purl.uniprot.org/uniprot/G7Q3B7 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9541:PEX5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2J4|||http://purl.uniprot.org/uniprot/A0A2K5U2K6|||http://purl.uniprot.org/uniprot/G7PJP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal targeting signal receptor family.|||Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:SDR16C5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXG8|||http://purl.uniprot.org/uniprot/I7GNN2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:YIF1B ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ98|||http://purl.uniprot.org/uniprot/A0A2K5TQA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/9541:LOC102134652 ^@ http://purl.uniprot.org/uniprot/Q4R871 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/9541:PARVA ^@ http://purl.uniprot.org/uniprot/A0A2K5TN80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parvin family.|||Cell membrane|||cytoskeleton http://togogenome.org/gene/9541:RCAN3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YCU2|||http://purl.uniprot.org/uniprot/G7NVW0 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/9541:TPBG ^@ http://purl.uniprot.org/uniprot/Q4R8Y9 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation ^@ Cell membrane|||Highly glycosylated.|||May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.|||The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway. http://togogenome.org/gene/9541:GLRA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WH11|||http://purl.uniprot.org/uniprot/A0A2K5WH44|||http://purl.uniprot.org/uniprot/A0A8J8Y2D0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9541:NLGN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:FOXM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQT6|||http://purl.uniprot.org/uniprot/A0A2K5UQV2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FAM83C ^@ http://purl.uniprot.org/uniprot/A0A2K5WPX4 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9541:NR1H4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYF5|||http://purl.uniprot.org/uniprot/A0A2K5TYG5|||http://purl.uniprot.org/uniprot/G7PJA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9541:HSD17B4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6D4 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9541:DYNLL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.|||Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9541:LOC102133077 ^@ http://purl.uniprot.org/uniprot/G8F3F9 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9541:LOC102123544 ^@ http://purl.uniprot.org/uniprot/Q95LN1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:FOXB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFL3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SUN3 ^@ http://purl.uniprot.org/uniprot/Q95LV7 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenesis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.|||Membrane|||Nucleus envelope|||Nucleus inner membrane|||Self-associates. Interacts with SYNE1 and SPAG4/SUN4. Proposed to form a spermatogenesis-specific LINC complex with SYNE1 during sperm head formation possibly implicating a SUN domain-based heterotrimer with SPAG4/SUN4 associating with SYNE1.|||The short coiled coil domain is proposed to be not involved in load-bearing and force transmission from the cytoskeleton but in mere nucleus anchorage instead. http://togogenome.org/gene/9541:ZNF274 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHX2|||http://purl.uniprot.org/uniprot/Q4R8H9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||Cytoplasm|||Interacts with SETDB1 and TRIM28/KAP1. Interacts with ATRX. Forms a complex with ATRX, SETDB1 and TRIM28.|||Nucleus|||Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (By similarity).|||nucleolus http://togogenome.org/gene/9541:NAA25 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY54 ^@ Similarity ^@ Belongs to the MDM20/NAA25 family. http://togogenome.org/gene/9541:MGST2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAJ7|||http://purl.uniprot.org/uniprot/G7P6B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:GOT1 ^@ http://purl.uniprot.org/uniprot/A0A805Q1X1|||http://purl.uniprot.org/uniprot/Q25L56|||http://purl.uniprot.org/uniprot/Q4R5L1 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.|||Cytoplasm|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/9541:GADD45G ^@ http://purl.uniprot.org/uniprot/A0A2K5X2X3 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9541:GRIK3 ^@ http://purl.uniprot.org/uniprot/Q38PU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily.|||Cell membrane|||Homotetramer, and heterotetramer with either GRIK4 or GRIK5. Interacts with PRKCABP (By similarity). Interacts with NETO2 (By similarity).|||Postsynaptic cell membrane|||Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA (By similarity). http://togogenome.org/gene/9541:BAG6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6Y8|||http://purl.uniprot.org/uniprot/A0A2K5U6Y9|||http://purl.uniprot.org/uniprot/G7P4P8 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).|||extracellular exosome http://togogenome.org/gene/9541:PRICKLE3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIT2|||http://purl.uniprot.org/uniprot/A0A2K5WJ07 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9541:CA11 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZV3|||http://purl.uniprot.org/uniprot/G7PY41 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Does not have a catalytic activity. http://togogenome.org/gene/9541:FIS1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPZ8|||http://purl.uniprot.org/uniprot/G7P145 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIS1 family.|||Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.|||Membrane|||Mitochondrion outer membrane|||The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. http://togogenome.org/gene/9541:MARCHF4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XS02|||http://purl.uniprot.org/uniprot/G7PLD9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NUP88 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4A1 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/9541:SLC30A6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9541:PGLYRP1 ^@ http://purl.uniprot.org/uniprot/Q18ND3 ^@ Function|||Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.|||Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. http://togogenome.org/gene/9541:DOCK5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVL2 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9541:ATG4A ^@ http://purl.uniprot.org/uniprot/A0A2K5X4I7|||http://purl.uniprot.org/uniprot/A0A2K5X4K0|||http://purl.uniprot.org/uniprot/A0A2K5X4K6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9541:STXBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGR0 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9541:MTMR8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYW1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9541:KCNB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X219 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.|||Cell membrane|||Membrane|||Perikaryon http://togogenome.org/gene/9541:CTSE ^@ http://purl.uniprot.org/uniprot/A0A2K5UJB7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A1 family.|||Endosome|||Homodimer; disulfide-linked.|||May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.|||Secreted http://togogenome.org/gene/9541:STAB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VS17 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:STAT4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:BZW2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1J4|||http://purl.uniprot.org/uniprot/G7P0T4 ^@ Similarity ^@ Belongs to the BZW family. http://togogenome.org/gene/9541:RNF112 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3J2 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9541:OVCA2 ^@ http://purl.uniprot.org/uniprot/G8F5I1 ^@ Similarity ^@ Belongs to the LovG family. http://togogenome.org/gene/9541:TIGD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIV0|||http://purl.uniprot.org/uniprot/G7P5X0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MS4A1 ^@ http://purl.uniprot.org/uniprot/M4ZHZ6 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9541:USP50 ^@ http://purl.uniprot.org/uniprot/Q4R6D3 ^@ Function|||Miscellaneous|||Similarity ^@ Belongs to the peptidase C19 family.|||May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).|||The human ortholog is inactive. http://togogenome.org/gene/9541:GPER1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYF2|||http://purl.uniprot.org/uniprot/A0A8J8YA21 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:EXO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIR1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.|||Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Nucleus http://togogenome.org/gene/9541:MAPRE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDS3|||http://purl.uniprot.org/uniprot/I7GI83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||centrosome|||spindle pole http://togogenome.org/gene/9541:F3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VX02|||http://purl.uniprot.org/uniprot/A0A2K5VX21 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tissue factor family.|||Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.|||Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.|||Membrane http://togogenome.org/gene/9541:NTF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted|||Seems to promote the survival of visceral and proprioceptive sensory neurons. http://togogenome.org/gene/9541:SLC35E3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VC19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NKIRAS2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XI33|||http://purl.uniprot.org/uniprot/G7PUT9 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/9541:CCL13 ^@ http://purl.uniprot.org/uniprot/A0A8J8YKY5|||http://purl.uniprot.org/uniprot/G7PU25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:MECP2 ^@ http://purl.uniprot.org/uniprot/Q95LG8 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).|||Interacts with FNBP3. Interacts with CDKL5. Interacts with ATRX; MECP2 recruits ATRX to pericentric heterochromatin in neuronal cells. Interacts with NCOR2. Interacts with TBL1XR1; bridges interaction between MECP2 and NCOR1. Interacts with TBL1X; recruits TBL1X to the heterochromatin foci (By similarity).|||Nucleus|||Phosphorylated on Ser-423 in brain upon synaptic activity, which attenuates its repressor activity and seems to regulate dendritic growth and spine maturation. http://togogenome.org/gene/9541:FAM91A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6H4 ^@ Similarity ^@ Belongs to the FAM91 family. http://togogenome.org/gene/9541:SEC24A ^@ http://purl.uniprot.org/uniprot/A0A2K5W3V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9541:LPL ^@ http://purl.uniprot.org/uniprot/A0A2K5WW23|||http://purl.uniprot.org/uniprot/A0A7N9D851|||http://purl.uniprot.org/uniprot/I7GCW6 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Cell membrane|||Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.|||Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.|||extracellular matrix http://togogenome.org/gene/9541:OAT ^@ http://purl.uniprot.org/uniprot/A0A2K5WLK4 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9541:MYO1D ^@ http://purl.uniprot.org/uniprot/A0A2K5V6Z7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:DPM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3B5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. http://togogenome.org/gene/9541:MAML2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mastermind family.|||Nucleus speckle http://togogenome.org/gene/9541:JMJD1C ^@ http://purl.uniprot.org/uniprot/A0A2K5X741 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TXNRD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHF5 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/9541:RTN4IP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTM8 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9541:NAA10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKW9 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/9541:APOA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYS4 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9541:AADACL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMV9 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9541:TLE5 ^@ http://purl.uniprot.org/uniprot/I7GPM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/9541:LOC102115526 ^@ http://purl.uniprot.org/uniprot/A0A2K5VU23|||http://purl.uniprot.org/uniprot/A0A2K5VU24 ^@ Similarity ^@ Belongs to the vacuolar ATPase subunit S1 family. http://togogenome.org/gene/9541:EPHB6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5C5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:UGT2B20 ^@ http://purl.uniprot.org/uniprot/A0A2K5V064|||http://purl.uniprot.org/uniprot/O77649 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane|||UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with androgens, such as testosterone, dihydrotestosterone (DHT) and 3-alpha-diol. It is also active on catecholoestrogens including 1,3,5,10-oestratriene-3,4-diol-17-one. http://togogenome.org/gene/9541:AMOTL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4D4|||http://purl.uniprot.org/uniprot/A0A2K5V4D9|||http://purl.uniprot.org/uniprot/A0A7N9CZ16|||http://purl.uniprot.org/uniprot/A0A7N9DDM7 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/9541:SDHAF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I LYR family. SDHAF3 subfamily.|||Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. http://togogenome.org/gene/9541:INPP5J ^@ http://purl.uniprot.org/uniprot/A0A2K5V4D2 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. http://togogenome.org/gene/9541:ZSCAN32 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTN5 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:ZDHHC7 ^@ http://purl.uniprot.org/uniprot/A0A2K5W162 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:CDC6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLB1|||http://purl.uniprot.org/uniprot/A0A2K5VLC8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC6/cdc18 family.|||Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.|||Nucleus http://togogenome.org/gene/9541:GPN2 ^@ http://purl.uniprot.org/uniprot/G8F2G8|||http://purl.uniprot.org/uniprot/Q4R579 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Heterodimers with GPN1 or GPN3. Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9541:ADSL ^@ http://purl.uniprot.org/uniprot/Q4R8X9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/9541:CCDC191 ^@ http://purl.uniprot.org/uniprot/Q95KD7 ^@ Sequence Caution ^@ Contaminating sequence. Potential poly-A sequence. http://togogenome.org/gene/9541:RRM1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YCP7|||http://purl.uniprot.org/uniprot/G7PQZ6 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/9541:B3GNT8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UK06|||http://purl.uniprot.org/uniprot/G7PXN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:DPAGT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y1S0|||http://purl.uniprot.org/uniprot/G7PPA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family.|||Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:PPP1R2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XWF8|||http://purl.uniprot.org/uniprot/G7NYS0 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 2 family. http://togogenome.org/gene/9541:LOC102120647 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0X6|||http://purl.uniprot.org/uniprot/G7PRP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNAJC25 family.|||Membrane http://togogenome.org/gene/9541:FMC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WU95|||http://purl.uniprot.org/uniprot/G8F3T3 ^@ Similarity ^@ Belongs to the FMC1 family. http://togogenome.org/gene/9541:SIAH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRW9|||http://purl.uniprot.org/uniprot/G7Q129 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9541:IL1RAPL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the interleukin-1 receptor family.|||axon|||dendrite http://togogenome.org/gene/9541:ARHGAP32 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3J4|||http://purl.uniprot.org/uniprot/A0A2K5X3S2 ^@ Similarity ^@ Belongs to the PX domain-containing GAP family. http://togogenome.org/gene/9541:BMPR1A ^@ http://purl.uniprot.org/uniprot/A0A2K5U1M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9541:NDUFAF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVW9 ^@ Function|||Similarity ^@ As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the CIA30 family. http://togogenome.org/gene/9541:MEIOB ^@ http://purl.uniprot.org/uniprot/Q4R8G6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MEIOB family.|||Chromosome|||Component of a multiprotein complex with RPA2 and SPATA22. Interacts with the complex BRME1:HSF2BP:BRCA2.|||Cytoplasm|||Nucleus|||Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro. http://togogenome.org/gene/9541:RRP15 ^@ http://purl.uniprot.org/uniprot/I7GPK6 ^@ Similarity ^@ Belongs to the RRP15 family. http://togogenome.org/gene/9541:STXBP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM77 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9541:EPHX1 ^@ http://purl.uniprot.org/uniprot/G8F5S8|||http://purl.uniprot.org/uniprot/Q2PG24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:MAN1C1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ17 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9541:CNTNAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WT80 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||paranodal septate junction http://togogenome.org/gene/9541:TPRG1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CF06 ^@ Similarity ^@ Belongs to the TPRG1 family. http://togogenome.org/gene/9541:CDCA8 ^@ http://purl.uniprot.org/uniprot/A0A8J8XFX2|||http://purl.uniprot.org/uniprot/G7NUA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the borealin family.|||centromere http://togogenome.org/gene/9541:GRHL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1Q4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:UTP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFL0 ^@ Similarity ^@ Belongs to the SAS10 family. http://togogenome.org/gene/9541:ARPC1B ^@ http://purl.uniprot.org/uniprot/A0A2K5WSY0|||http://purl.uniprot.org/uniprot/G7P0A3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||Nucleus|||cytoskeleton http://togogenome.org/gene/9541:VPS11 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6Q1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS11 family.|||Cytoplasmic vesicle|||Early endosome|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.|||autophagosome|||clathrin-coated vesicle http://togogenome.org/gene/9541:AKT1 ^@ http://purl.uniprot.org/uniprot/G7PBQ9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/9541:STAT6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W338|||http://purl.uniprot.org/uniprot/G8F510 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:INPP5A ^@ http://purl.uniprot.org/uniprot/A0A2K5WCA5|||http://purl.uniprot.org/uniprot/A0A2K5WCB1 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family. http://togogenome.org/gene/9541:NKG7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TM29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9541:MIEF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X623 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:CABS1 ^@ http://purl.uniprot.org/uniprot/Q95JW6 ^@ Function|||Subcellular Location Annotation ^@ Calcium-binding protein (By similarity). Essential for maintaining the structural integrity of the sperm flagella (By similarity).|||Cytoplasm|||Mitochondrion inner membrane|||acrosome|||flagellum http://togogenome.org/gene/9541:CLDN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWF3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:HARS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7T9|||http://purl.uniprot.org/uniprot/A0A2K5W7W5|||http://purl.uniprot.org/uniprot/A0A7N9C9L7 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:PKMYT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X347 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:CYP11B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULU3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:S100A1 ^@ http://purl.uniprot.org/uniprot/I7GDD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Mitochondrion http://togogenome.org/gene/9541:GOLT1B ^@ http://purl.uniprot.org/uniprot/A0A2K5VSP7|||http://purl.uniprot.org/uniprot/G7PK08|||http://purl.uniprot.org/uniprot/I7G9I3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/9541:KDM5C ^@ http://purl.uniprot.org/uniprot/A0A2K5X0F4|||http://purl.uniprot.org/uniprot/A0A2K5X139|||http://purl.uniprot.org/uniprot/G7Q2S8 ^@ Similarity ^@ Belongs to the JARID1 histone demethylase family. http://togogenome.org/gene/9541:ENY2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMX1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.|||nucleoplasm http://togogenome.org/gene/9541:SPTSSA ^@ http://purl.uniprot.org/uniprot/I7GMV0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:LOC102136862 ^@ http://purl.uniprot.org/uniprot/S6E293 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9541:STX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VP25 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9541:LOC102142948 ^@ http://purl.uniprot.org/uniprot/G7NZ60 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:AQP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9541:LOC102145920 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4P7 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9541:HSD17B5 ^@ http://purl.uniprot.org/uniprot/Q2XQY3 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family.|||Monomer. http://togogenome.org/gene/9541:UBE2I ^@ http://purl.uniprot.org/uniprot/A0A2K5VMB3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:ARF5 ^@ http://purl.uniprot.org/uniprot/I7G7I5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9541:NOP56 ^@ http://purl.uniprot.org/uniprot/Q95K50 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NOP5/NOP56 family.|||Cytoplasm|||Involved in the early to middle stages of 60S ribosomal subunit biogenesis.|||Part of a large pre-ribosomal ribonucleoprotein (RNP) complex, that consists of at least 62 ribosomal proteins, 45 nonribosomal proteins and both pre-rRNA and mature rRNA species. Within this complex directly interacts with TCOF1 in an RNA-independent manner. Interacts with NOP1 and NOP58 (By similarity).|||nucleolus http://togogenome.org/gene/9541:BCKDHA ^@ http://purl.uniprot.org/uniprot/Q8HXY4 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BCKDHA family.|||Bound potassium ions stabilize the protein structure.|||Heterotetramer of alpha and beta chains.|||Mitochondrion matrix|||The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/9541:TARS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQC0|||http://purl.uniprot.org/uniprot/A0A2K5UQD1 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:SF3A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ38|||http://purl.uniprot.org/uniprot/G7PF65 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:HSPA5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9541:MOB3B ^@ http://purl.uniprot.org/uniprot/A0A8J8YK25|||http://purl.uniprot.org/uniprot/G7PS66 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9541:TAF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF2 family.|||Nucleus http://togogenome.org/gene/9541:SDHAF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UG52 ^@ Similarity ^@ Belongs to the complex I LYR family. SDHAF1 subfamily. http://togogenome.org/gene/9541:FAM167A ^@ http://purl.uniprot.org/uniprot/A0A2K5TLR1 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/9541:LOC102142564 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNB1 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/9541:CHGA ^@ http://purl.uniprot.org/uniprot/Q4R4V1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/9541:LOC102118346 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDC3 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9541:ANP32E ^@ http://purl.uniprot.org/uniprot/I7GLD0 ^@ Similarity ^@ Belongs to the ANP32 family. http://togogenome.org/gene/9541:DMRT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3K0 ^@ Similarity ^@ Belongs to the DMRT family. http://togogenome.org/gene/9541:RPL5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJC0|||http://purl.uniprot.org/uniprot/Q4R5M0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Component of the large ribosomal subunit (LSU). Part of a LSU subcomplex, the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11. Interacts with NVL in an ATP-dependent manner. Interacts with RRP1B (By similarity). Interacts with IPO5, IPO7 and KPNB1; these interactions may be involved in RPL5 nuclear import for the assembly of ribosomal subunits (By similarity).|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Interacts with RRP1B.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9541:AK3 ^@ http://purl.uniprot.org/uniprot/I7GH42 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/9541:TRAF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUH5|||http://purl.uniprot.org/uniprot/G7PRJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9541:XRCC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Cytoplasm|||Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.|||Nucleus http://togogenome.org/gene/9541:CYP24A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTI6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:ATP2B4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGT1|||http://purl.uniprot.org/uniprot/A0A2K5UGU3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:TEX10 ^@ http://purl.uniprot.org/uniprot/A0A8J8YD58|||http://purl.uniprot.org/uniprot/G7PRU3 ^@ Similarity ^@ Belongs to the IPI1/TEX10 family. http://togogenome.org/gene/9541:CPSF7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TT78 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:IFI30 ^@ http://purl.uniprot.org/uniprot/A0A2K5WH71 ^@ Similarity|||Subunit ^@ Belongs to the GILT family.|||Dimer; disulfide-linked. http://togogenome.org/gene/9541:DIS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKV5|||http://purl.uniprot.org/uniprot/A0A2K5UKW9 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/9541:IL11RA ^@ http://purl.uniprot.org/uniprot/A0A2K5VLM5 ^@ Similarity ^@ Belongs to the type I cytokine receptor family. Type 3 subfamily. http://togogenome.org/gene/9541:TMEM256 ^@ http://purl.uniprot.org/uniprot/A0A8J8YPW7|||http://purl.uniprot.org/uniprot/G7PTH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM256 family.|||Membrane http://togogenome.org/gene/9541:HMGB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9541:FMOD ^@ http://purl.uniprot.org/uniprot/A0A8J8XQM4|||http://purl.uniprot.org/uniprot/G7NVF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.|||Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.|||Binds to type I and type II collagen.|||extracellular matrix http://togogenome.org/gene/9541:LOC102124806 ^@ http://purl.uniprot.org/uniprot/A0A2K5V886|||http://purl.uniprot.org/uniprot/G7PGE5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.|||Secreted|||When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14. http://togogenome.org/gene/9541:TBL1XR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDM4|||http://purl.uniprot.org/uniprot/G7NZ35 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/9541:WNT2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZG3|||http://purl.uniprot.org/uniprot/G7P2I9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:IL13RA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCT5 ^@ Similarity ^@ Belongs to the type I cytokine receptor family. Type 5 subfamily. http://togogenome.org/gene/9541:LOC102144897 ^@ http://purl.uniprot.org/uniprot/Q9GLZ9 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).|||Interacts with NFATC2, TRAF1, TRAF2 and PRMT1. Interacts with UBE2I/UBC9 (By similarity).|||Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production.|||Nucleus http://togogenome.org/gene/9541:ADH6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7A0 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9541:MESD ^@ http://purl.uniprot.org/uniprot/I7GK02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MESD family.|||Endoplasmic reticulum http://togogenome.org/gene/9541:ATP1A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UV79 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:MICAL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mical family.|||Cytoplasm http://togogenome.org/gene/9541:LOC102130773 ^@ http://purl.uniprot.org/uniprot/A0A8J8YM65|||http://purl.uniprot.org/uniprot/G7PZT7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9541:LOC102120931 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0H3|||http://purl.uniprot.org/uniprot/G7PCD4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:RNF114 ^@ http://purl.uniprot.org/uniprot/Q4R3J4 ^@ Subunit ^@ Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling. http://togogenome.org/gene/9541:TMCC1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTR9|||http://purl.uniprot.org/uniprot/G7PIM5 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9541:TCP1 ^@ http://purl.uniprot.org/uniprot/Q4R5G2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Interacts with GBA1 (By similarity). Interacts with DLEC1 (By similarity).|||Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.|||centrosome|||cytosol http://togogenome.org/gene/9541:IFIH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9541:FLT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TMOD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4S9|||http://purl.uniprot.org/uniprot/G7PRW3 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:FRK ^@ http://purl.uniprot.org/uniprot/A0A2K5X900 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9541:HOXD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9541:KRT32 ^@ http://purl.uniprot.org/uniprot/A0A2K5VW92 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:CLRN3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YJZ2|||http://purl.uniprot.org/uniprot/G7PEC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9541:CLCA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSF6 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/9541:SRF ^@ http://purl.uniprot.org/uniprot/A0A2K5VDS4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:HAO2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W646|||http://purl.uniprot.org/uniprot/A0A2K5W668 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/9541:MCPH1 ^@ http://purl.uniprot.org/uniprot/Q5IFK1 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ BRCT domain 1 is required to prevent abnormal chromosome condensation. It binds directly to the SWI-SNF chromatin remodeling complex (By similarity).|||BRCT domains 2 and 3 recognize phosphoserine/phosphothreonine marks on proteins with high selectivity, and mediate interaction with phosphorylated CDC27. They also mediate the dual recognition of phosphoserine and phosphotyrosine in the C-terminal tail of histone H2AX (By similarity).|||Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex (By similarity).|||Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions (By similarity).|||centrosome http://togogenome.org/gene/9541:LOC102137233 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVY5 ^@ Similarity ^@ Belongs to the histone H2B family. http://togogenome.org/gene/9541:USP16 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNN7 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. USP16 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Homotetramer.|||Nucleus|||Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.|||Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.|||The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin. http://togogenome.org/gene/9541:PPP2R2B ^@ http://purl.uniprot.org/uniprot/A0A158SIQ6|||http://purl.uniprot.org/uniprot/A0A2K5U1Q0|||http://purl.uniprot.org/uniprot/A0A2K5U1Q5|||http://purl.uniprot.org/uniprot/A0A2K5U1U5|||http://purl.uniprot.org/uniprot/G7P8L1|||http://purl.uniprot.org/uniprot/Q4R8L3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatase 2A regulatory subunit B family.|||Cytoplasm|||Membrane|||PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with TOMM22 (By similarity). Interacts with IER5 (via N- and C-terminal regions) (By similarity).|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.|||cytoskeleton http://togogenome.org/gene/9541:GRB10 ^@ http://purl.uniprot.org/uniprot/A0A2K5U186 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/9541:NAGA ^@ http://purl.uniprot.org/uniprot/A0A2K5U017 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/9541:PTGER3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLN4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:MFSD10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMB8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NANOS2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQ98|||http://purl.uniprot.org/uniprot/G7PXX8 ^@ Similarity ^@ Belongs to the nanos family. http://togogenome.org/gene/9541:SUSD6 ^@ http://purl.uniprot.org/uniprot/A0A8J8YKY7|||http://purl.uniprot.org/uniprot/G7PAR2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:P2RY1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTW9|||http://purl.uniprot.org/uniprot/G7NZL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SNX19 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCE8 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9541:TAF5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVW2 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/9541:TAS2R7 ^@ http://purl.uniprot.org/uniprot/G7PJU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.|||Membrane http://togogenome.org/gene/9541:GDE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ26 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9541:LIN7C ^@ http://purl.uniprot.org/uniprot/A0A2K5VUH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/9541:BORA ^@ http://purl.uniprot.org/uniprot/A0A2K5VU98 ^@ Similarity ^@ Belongs to the BORA family. http://togogenome.org/gene/9541:LSM8 ^@ http://purl.uniprot.org/uniprot/G7P0I5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. http://togogenome.org/gene/9541:CATSPERG ^@ http://purl.uniprot.org/uniprot/Q4R6B2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.|||Belongs to the CATSPERG family.|||Component of the CatSper complex or CatSpermasome composed of the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 as well as auxiliary members CATSPERB, CATSPERG, CATSPERD, CATSPERE, CATSPERZ, SCLO6C1, TMEM249, TMEM262 and EFCAB9. HSPA1 may be an additional auxiliary complex member. The core complex members CATSPER1, CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel. The auxiliary CATSPERB, CATSPERG, CATSPERD and CATSPERE subunits form a pavilion-like structure over the pore which stabilizes the complex through interactions with CATSPER4, CATSPER3, CATSPER1 and CATSPER2 respectively. TMEM262/CATSPERH interacts with CATSPERB, further stabilizing the complex. C2CD6/CATSPERT interacts at least with CATSPERD and is required for targeting the CatSper complex in the flagellar membrane.|||In mouse, Slco6c1 is an additional auxiliary subunit of the CatSper complex. It is unclear if the related SLCO6A1 protein performs the same role in non-rodent species.|||flagellum membrane http://togogenome.org/gene/9541:NPR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQF7|||http://purl.uniprot.org/uniprot/A0A2K5WQM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/9541:OTULINL ^@ http://purl.uniprot.org/uniprot/A0A2K5WIK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/9541:GLDN ^@ http://purl.uniprot.org/uniprot/A0A2K5WW73 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ST6GALNAC4 ^@ http://purl.uniprot.org/uniprot/Q2PG21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:GASK1A ^@ http://purl.uniprot.org/uniprot/A0A2K5UW93 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/9541:GCG ^@ http://purl.uniprot.org/uniprot/A0A2K5WWG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/9541:USP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGL8|||http://purl.uniprot.org/uniprot/A0A2K5UGQ7 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9541:ABRACL ^@ http://purl.uniprot.org/uniprot/A0A2K5WRC0|||http://purl.uniprot.org/uniprot/G7P319 ^@ Similarity ^@ Belongs to the costars family. http://togogenome.org/gene/9541:ORC2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQH4|||http://purl.uniprot.org/uniprot/Q4R797 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC2 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Component of the origin recognition complex (ORC).|||Nucleus http://togogenome.org/gene/9541:ATP6V0D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X956 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9541:RPS13 ^@ http://purl.uniprot.org/uniprot/A0A2K5V043 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/9541:MASP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2F7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:DDI1 ^@ http://purl.uniprot.org/uniprot/Q95JI3 ^@ Function|||Similarity ^@ Belongs to the DDI1 family.|||Probable aspartic protease (By similarity). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required, with DDI2, for cellular survival following replication stress. Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (By similarity). http://togogenome.org/gene/9541:NDUFAF7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UX74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Belongs to the NDUFAF7 family.|||Mitochondrion http://togogenome.org/gene/9541:URM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBC9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.|||Belongs to the URM1 family.|||C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.|||Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.|||Cytoplasm http://togogenome.org/gene/9541:SPSB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYN2 ^@ Function|||Similarity ^@ Belongs to the SPSB family.|||May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9541:PPFIA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6C9|||http://purl.uniprot.org/uniprot/A0A2K5V6D7|||http://purl.uniprot.org/uniprot/A0A2K5V6H0 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/9541:IL23A ^@ http://purl.uniprot.org/uniprot/G7PIH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9541:STRIP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WW75 ^@ Similarity ^@ Belongs to the STRIP family. http://togogenome.org/gene/9541:PATL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ26|||http://purl.uniprot.org/uniprot/A0A2K5WQH7 ^@ Similarity ^@ Belongs to the PAT1 family. http://togogenome.org/gene/9541:HIF3A ^@ http://purl.uniprot.org/uniprot/A0A2K5UJT7|||http://purl.uniprot.org/uniprot/A0A2K5UJU9 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9541:NUDT12 ^@ http://purl.uniprot.org/uniprot/Q4R7L8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. NudC subfamily.|||Binds 1 zinc ion per subunit.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Cytoplasmic granule|||Homodimer (By similarity). Homodimerization is essential for its catalytic activity and protein stability (By similarity). Interacts (via ANK repeats) with BLMH (By similarity).|||Peroxisome|||mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to nutrient stress (By similarity). Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (By similarity). Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver (By similarity). http://togogenome.org/gene/9541:POMK ^@ http://purl.uniprot.org/uniprot/Q95JJ0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Although related to the Ser/Thr protein kinase family, has no protein kinase activity and acts as a mannose kinase instead.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.|||Endoplasmic reticulum membrane|||Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif (By similarity). http://togogenome.org/gene/9541:SLC34A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHY1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Involved in actively transporting phosphate into cells via Na(+) cotransport.|||Membrane http://togogenome.org/gene/9541:ACHE ^@ http://purl.uniprot.org/uniprot/A0A2K5WJG1|||http://purl.uniprot.org/uniprot/A0A2K5WJM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Secreted http://togogenome.org/gene/9541:ACER3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WV75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Membrane http://togogenome.org/gene/9541:TLE3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCV9|||http://purl.uniprot.org/uniprot/A0A2K5WD15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/9541:CYP1B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UT62|||http://purl.uniprot.org/uniprot/A0A7N9D2X8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:OPN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VU14 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:NT5C2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YBL1|||http://purl.uniprot.org/uniprot/G7PDV7 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/9541:IMMT ^@ http://purl.uniprot.org/uniprot/A0A2K5VNW6|||http://purl.uniprot.org/uniprot/A0A2K5VP54|||http://purl.uniprot.org/uniprot/A0A2K5VPB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic60 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:RPS6KA5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VW22|||http://purl.uniprot.org/uniprot/A0A2K5VW70 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9541:ACTR3B ^@ http://purl.uniprot.org/uniprot/A0A2K5WHL6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:DDIT4L ^@ http://purl.uniprot.org/uniprot/A0A8J8XRQ5|||http://purl.uniprot.org/uniprot/G7P5Z9 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/9541:SERPINA6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXZ3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:TAL2 ^@ http://purl.uniprot.org/uniprot/G7PRR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LicD transferase family.|||Golgi apparatus membrane http://togogenome.org/gene/9541:OXSR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U411|||http://purl.uniprot.org/uniprot/G7NYK6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/9541:KDR ^@ http://purl.uniprot.org/uniprot/A0A2K5VE63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ADCYAP1R1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6R8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GLS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VU75 ^@ Similarity ^@ Belongs to the glutaminase family. http://togogenome.org/gene/9541:LTV1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WV65 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/9541:AVPR1B ^@ http://purl.uniprot.org/uniprot/F6N687 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. http://togogenome.org/gene/9541:MAP1LC3C ^@ http://purl.uniprot.org/uniprot/A0A2K5X4B0 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9541:TUBB4B ^@ http://purl.uniprot.org/uniprot/I7GH35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9541:MS4A5 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y424|||http://purl.uniprot.org/uniprot/G7PQ01|||http://purl.uniprot.org/uniprot/Q4R3P9 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9541:FKBP11 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4D8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9541:RPL39L ^@ http://purl.uniprot.org/uniprot/A0A2K5UF67 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9541:ADAMTS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFV4 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:SPTLC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQA1|||http://purl.uniprot.org/uniprot/G7PGZ7 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9541:HPRT1 ^@ http://purl.uniprot.org/uniprot/Q6LDD9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein.|||Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/9541:TBX15 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLD0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:BCL9L ^@ http://purl.uniprot.org/uniprot/A0A2K5WQH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BCL9 family.|||Nucleus http://togogenome.org/gene/9541:SEH1L ^@ http://purl.uniprot.org/uniprot/A0A2K5UCH9|||http://purl.uniprot.org/uniprot/A0A7N9D3S3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.|||Lysosome membrane|||kinetochore http://togogenome.org/gene/9541:CD79A ^@ http://purl.uniprot.org/uniprot/A0A2K5U9J5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:ABCB6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM96 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Homodimer.|||Late endosome membrane|||Lysosome membrane|||Melanosome membrane|||Membrane|||Mitochondrion outer membrane|||extracellular exosome|||multivesicular body membrane http://togogenome.org/gene/9541:HLCS ^@ http://purl.uniprot.org/uniprot/A0A2K5UVI9 ^@ Similarity ^@ Belongs to the biotin--protein ligase family. http://togogenome.org/gene/9541:TGFB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.|||extracellular matrix http://togogenome.org/gene/9541:OAS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X516 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-5A synthase family.|||Cytoplasm http://togogenome.org/gene/9541:FAM98A ^@ http://purl.uniprot.org/uniprot/A0A2K5UTV3 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/9541:KLHL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGW0|||http://purl.uniprot.org/uniprot/A0A2K5WH52|||http://purl.uniprot.org/uniprot/A0A7N9D103 ^@ Subcellular Location Annotation ^@ cytoskeleton|||cytosol http://togogenome.org/gene/9541:RBFOX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGN0|||http://purl.uniprot.org/uniprot/A0A2K5WGS3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||RNA-binding protein that regulates alternative splicing events. http://togogenome.org/gene/9541:ADAMTS18 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBT7 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:FAM214A ^@ http://purl.uniprot.org/uniprot/A0A2K5TQB7|||http://purl.uniprot.org/uniprot/A0A2K5TQC4 ^@ Similarity ^@ Belongs to the FAM214 family. http://togogenome.org/gene/9541:SLC35F2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVI2|||http://purl.uniprot.org/uniprot/A0A7N9CJ66|||http://purl.uniprot.org/uniprot/G7PNQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/9541:NAB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X146|||http://purl.uniprot.org/uniprot/A0A2K5X172|||http://purl.uniprot.org/uniprot/A0A7N9CY18 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAB family.|||Homomultimers may associate with EGR1 bound to DNA.|||Nucleus http://togogenome.org/gene/9541:SNX10 ^@ http://purl.uniprot.org/uniprot/A0A2K5X9H7|||http://purl.uniprot.org/uniprot/G7P0P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/9541:BTF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8X8 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9541:ABLIM3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQ07|||http://purl.uniprot.org/uniprot/A0A2K5VQ10|||http://purl.uniprot.org/uniprot/A0A2K5VQ57 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:OXER1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQ10|||http://purl.uniprot.org/uniprot/G7PM35 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:CCDC103 ^@ http://purl.uniprot.org/uniprot/A0A2K5TU89 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC103/PR46b family.|||Cytoplasm|||Dynein-attachment factor required for cilia motility.|||Homodimer.|||flagellum http://togogenome.org/gene/9541:B9D2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y908|||http://purl.uniprot.org/uniprot/G7PXN5 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9541:RHPN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VF29 ^@ Similarity ^@ Belongs to the RHPN family. http://togogenome.org/gene/9541:BPIFC ^@ http://purl.uniprot.org/uniprot/A0A2K5UK05 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Monomer. Homodimer; disulfide-linked.|||Secreted|||The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.|||The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.|||The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. http://togogenome.org/gene/9541:ADIPOR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDE4|||http://purl.uniprot.org/uniprot/G8F668 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9541:LOC102117390 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRJ9 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/9541:PTGES ^@ http://purl.uniprot.org/uniprot/G7PRD3|||http://purl.uniprot.org/uniprot/Q6PWL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MAPEG family.|||Homotrimer.|||Membrane|||Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (By similarity). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity).|||perinuclear region http://togogenome.org/gene/9541:GRAP2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CZE0|||http://purl.uniprot.org/uniprot/A0A8J8XTA5|||http://purl.uniprot.org/uniprot/G7PFL4|||http://purl.uniprot.org/uniprot/Q4R3G7 ^@ Similarity ^@ Belongs to the GRB2/sem-5/DRK family. http://togogenome.org/gene/9541:PPP1R3B ^@ http://purl.uniprot.org/uniprot/A0A2K5TP98 ^@ Subunit ^@ Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity. http://togogenome.org/gene/9541:LAGE3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDF7 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/9541:KIF7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKT0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:STUM ^@ http://purl.uniprot.org/uniprot/A0A2K5TT72 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LYPLAL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7H8 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/9541:FSCN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9M8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/9541:PROS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VES4|||http://purl.uniprot.org/uniprot/G7NZ62 ^@ Caution|||Function ^@ Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC102115394 ^@ http://purl.uniprot.org/uniprot/A0A7N9CNV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:MCOLN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8F3|||http://purl.uniprot.org/uniprot/A0A7N9CPM3|||http://purl.uniprot.org/uniprot/A0A7N9CU40 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9541:SPR ^@ http://purl.uniprot.org/uniprot/A0A8J8YLX2|||http://purl.uniprot.org/uniprot/G7PMG9 ^@ Similarity ^@ Belongs to the sepiapterin reductase family. http://togogenome.org/gene/9541:CYP4F11 ^@ http://purl.uniprot.org/uniprot/A0A2K5X292|||http://purl.uniprot.org/uniprot/A8CBR8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:SPOUT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGR3 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. http://togogenome.org/gene/9541:LOC102144154 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9A2|||http://purl.uniprot.org/uniprot/G8F4K7 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:NDUFA8 ^@ http://purl.uniprot.org/uniprot/A0A8J8XH60|||http://purl.uniprot.org/uniprot/G7PRI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA8 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9541:SLC40A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0L1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May be involved in iron transport and iron homeostasis.|||Membrane http://togogenome.org/gene/9541:BSX ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ41 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC101867207 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2K7|||http://purl.uniprot.org/uniprot/Q4R7U5 ^@ Similarity|||Subunit ^@ Belongs to the peptidase M18 family.|||Tetrahedron-shaped homododecamer built from six homodimers. http://togogenome.org/gene/9541:LOC107129805 ^@ http://purl.uniprot.org/uniprot/A0A7N9IBE1 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/9541:EMC6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKN3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC6 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:GRID2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9541:GAREM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4S9 ^@ Similarity ^@ Belongs to the GAREM family. http://togogenome.org/gene/9541:PDK4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UB94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9541:PIGM ^@ http://purl.uniprot.org/uniprot/Q4R4E1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGM family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly (By similarity). http://togogenome.org/gene/9541:EGR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UL28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus|||Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. http://togogenome.org/gene/9541:TTC26 ^@ http://purl.uniprot.org/uniprot/Q4R7Z9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IFT56 family.|||Component of the IFT complex B. Interacts with IFT46; the interaction is direct.|||Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme.|||cilium http://togogenome.org/gene/9541:TSC22D1 ^@ http://purl.uniprot.org/uniprot/Q4R4H5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TSC-22/Dip/Bun family.|||Cytoplasm|||Homodimer or heterodimer. Can form a heterodimer with TSC22D4 (By similarity).|||Nucleus|||Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter (By similarity). http://togogenome.org/gene/9541:SLC43A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V693 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PRKD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.|||Membrane http://togogenome.org/gene/9541:SLC19A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8N0|||http://purl.uniprot.org/uniprot/A0A7N9DDZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.|||Membrane http://togogenome.org/gene/9541:CNIH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9541:COLGALT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAQ2|||http://purl.uniprot.org/uniprot/A0A7N9CJM5 ^@ Similarity ^@ Belongs to the glycosyltransferase 25 family. http://togogenome.org/gene/9541:INPP4B ^@ http://purl.uniprot.org/uniprot/A0A2K5UC87|||http://purl.uniprot.org/uniprot/A0A2K5UC97 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/9541:CERS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WN20 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:UNKL ^@ http://purl.uniprot.org/uniprot/A0A2K5X8X1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:ITIH5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9541:EIF4E2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0W5|||http://purl.uniprot.org/uniprot/A0A2K5U0X6|||http://purl.uniprot.org/uniprot/A0A2K5U110|||http://purl.uniprot.org/uniprot/G7PKB1 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9541:FEZ1 ^@ http://purl.uniprot.org/uniprot/Q4R5K8 ^@ Similarity ^@ Belongs to the zygin family. http://togogenome.org/gene/9541:YWHAB ^@ http://purl.uniprot.org/uniprot/A0A158SIP8|||http://purl.uniprot.org/uniprot/Q4R572 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.|||Belongs to the 14-3-3 family.|||Cytoplasm|||Homodimer (By similarity). Interacts with SAMSN1 and PRKCE (By similarity). Interacts with AKAP13. Interacts with SSH1 and TORC2/CRTC2. Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues. Interacts with GAB2. Interacts with YAP1 (phosphorylated form). Interacts with the phosphorylated (by AKT1) form of SRPK2. Interacts with PKA-phosphorylated AANAT. Interacts with MYO1C. Interacts with SIRT2 (By similarity). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B. Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (By similarity). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (By similarity). Interacts with SLITRK1. Interacts with SYNPO2 (phosphorylated form); YWHAB competes with ACTN2 for interaction with SYNPO2 (By similarity). Interacts with RIPOR2 (via phosphorylated form); this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2-mediated RHOA activity (By similarity). Interacts with MARK2 and MARK3 (By similarity). Interacts with TESK1; the interaction is dependent on the phosphorylation of TESK1 'Ser-437' and inhibits TESK1 kinase activity (By similarity). Interacts with MEFV (By similarity). Interacts with HDAC4 (By similarity). Interacts with ADAM22 (via C-terminus) (By similarity).|||Inferred by similarity.|||Isoform Short contains a N-acetylmethionine at position 1.|||Melanosome|||The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. http://togogenome.org/gene/9541:SLC25A15 ^@ http://purl.uniprot.org/uniprot/G7PW31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:ADAM23 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPI1|||http://purl.uniprot.org/uniprot/A0A2K5UPI8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:VKORC1L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VKOR family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:P2RX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNC1|||http://purl.uniprot.org/uniprot/G7PT77 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9541:ZSCAN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5D7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SERINC5 ^@ http://purl.uniprot.org/uniprot/Q4R6L9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Cell membrane|||Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm (By similarity). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity). http://togogenome.org/gene/9541:LOC102146580 ^@ http://purl.uniprot.org/uniprot/A0A2K5UP26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PPDPF ^@ http://purl.uniprot.org/uniprot/A0A2K5X4I8 ^@ Similarity ^@ Belongs to the PPDPF family. http://togogenome.org/gene/9541:LOC102123292 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SGSM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5N8|||http://purl.uniprot.org/uniprot/A0A2K5U5R1 ^@ Similarity ^@ Belongs to the RUTBC family. http://togogenome.org/gene/9541:TIGD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIP8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MYOF ^@ http://purl.uniprot.org/uniprot/A0A2K5W417|||http://purl.uniprot.org/uniprot/A0A2K5W466|||http://purl.uniprot.org/uniprot/A0A2K5W479 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ferlin family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9541:UGT2B23 ^@ http://purl.uniprot.org/uniprot/Q9TSL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Expressed in several tissues, including the prostate, mammary gland, epididymis, testis and ovary.|||Microsome membrane|||UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on 6 steroids and the bile acid, hyodeoxycholic acid. May potentially play an important role in estrogen and androgen catabolism in peripheral steroid target tissues. http://togogenome.org/gene/9541:KIF1C ^@ http://purl.uniprot.org/uniprot/A0A2K5WN76 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:PSMA8 ^@ http://purl.uniprot.org/uniprot/Q4R7D9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. PSMA7 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly. Interacts with HIF1A. Interacts with RAB7A. Interacts with PRKN. Interacts with ABL1 and ABL2. Interacts with EMAP2. Interacts with MAVS. http://togogenome.org/gene/9541:EIF6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UX53 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).|||Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.|||nucleolus http://togogenome.org/gene/9541:CYP2D6 ^@ http://purl.uniprot.org/uniprot/D9DB13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:SLIT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ46|||http://purl.uniprot.org/uniprot/A0A2K5TJ59 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:FA2H ^@ http://purl.uniprot.org/uniprot/Q4R4P4 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sterol desaturase family. SCS7 subfamily.|||Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.|||Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids (By similarity). Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (By similarity). Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (By similarity). Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins (By similarity).|||Endoplasmic reticulum membrane|||Microsome membrane|||The N-terminal cytochrome b5 heme-binding domain is essential for catalytic activity.|||The histidine box domains may contain the active site and/or be involved in metal ion binding. http://togogenome.org/gene/9541:GADL1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XCW0|||http://purl.uniprot.org/uniprot/G7NYB1 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9541:TRAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WV36 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/9541:LOC102133592 ^@ http://purl.uniprot.org/uniprot/A0A2K5U236 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9541:FEN1 ^@ http://purl.uniprot.org/uniprot/G7PPX3|||http://purl.uniprot.org/uniprot/Q4R5U5 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300.|||Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300. Can bind simultaneously to both PCNA and EP300. Interacts with DDX11.|||Methylation at Arg-192 by PRMT5 impedes Ser-187 phosphorylation and increases interaction with PCNA.|||Mitochondrion|||Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Phosphorylation at Ser-187 by CDK2 occurs during late S-phase and results in dissociation from PCNA.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.|||Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300; can bind simultaneously to both PCNA and EP300. Interacts with PCNA; can bind simultaneously to both PCNA and EP300. Interacts with DDX11; this interaction is direct and increases flap endonuclease activity of FEN1. Interacts with WDR4; regulating its endonuclease activity.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9541:DDIT4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7L1|||http://purl.uniprot.org/uniprot/G7PF25 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/9541:CELF6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U145 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:PCMTD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCL8|||http://purl.uniprot.org/uniprot/A0A2K5UCP9 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9541:SLC25A32 ^@ http://purl.uniprot.org/uniprot/Q95J75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Mitochondrion inner membrane|||Transports folate across the inner membranes of mitochondria (By similarity). Can also transport FAD across the mitochondrial inner membrane (By similarity). http://togogenome.org/gene/9541:AP1S1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||clathrin-coated pit http://togogenome.org/gene/9541:CYP2C9 ^@ http://purl.uniprot.org/uniprot/Q0HA18 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:ELAPOR1 ^@ http://purl.uniprot.org/uniprot/Q4R682 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELAPOR family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:POPDC3 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y1R0|||http://purl.uniprot.org/uniprot/G7P447 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9541:MANSC1 ^@ http://purl.uniprot.org/uniprot/Q95KG7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GCN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDP7 ^@ Similarity ^@ Belongs to the GCN1 family. http://togogenome.org/gene/9541:CENPO ^@ http://purl.uniprot.org/uniprot/A0A2K5UWM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-O/MCM21 family.|||Nucleus http://togogenome.org/gene/9541:MAN2A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRI5 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9541:IP6K2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWS7 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9541:GJD4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UY53|||http://purl.uniprot.org/uniprot/Q9N0B3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Belongs to the connexin family. Delta-type subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9541:PAQR5 ^@ http://purl.uniprot.org/uniprot/A0A8J8YRD9|||http://purl.uniprot.org/uniprot/G7P902 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9541:LYAR ^@ http://purl.uniprot.org/uniprot/A0A2K5V2R1|||http://purl.uniprot.org/uniprot/Q4R4E6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:PRMT7 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8F8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.|||Nucleus|||cytosol http://togogenome.org/gene/9541:ACSF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZB6|||http://purl.uniprot.org/uniprot/Q4R4Z9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.|||Belongs to the ATP-dependent AMP-binding enzyme family.|||Mitochondrion http://togogenome.org/gene/9541:COPS7A ^@ http://purl.uniprot.org/uniprot/A0A8J8Y6V2|||http://purl.uniprot.org/uniprot/G7PJN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:TMEM182 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3P0|||http://purl.uniprot.org/uniprot/A0A2K5W3P3|||http://purl.uniprot.org/uniprot/A0A7N9CPH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ERMN ^@ http://purl.uniprot.org/uniprot/A0A8J8YRE1|||http://purl.uniprot.org/uniprot/G7PKL9 ^@ Function|||Subunit ^@ Binds actin.|||Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS. http://togogenome.org/gene/9541:FGF10 ^@ http://purl.uniprot.org/uniprot/Q95K97 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:HSDL2 ^@ http://purl.uniprot.org/uniprot/G7PRN7 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9541:SLC17A3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYE1|||http://purl.uniprot.org/uniprot/G7P2K7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ADGRF5 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4I8|||http://purl.uniprot.org/uniprot/A0A2K5W4M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/9541:PSMA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W387|||http://purl.uniprot.org/uniprot/Q4R3H2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Interacts with NOTCH3. Interacts with ZFAND1 (By similarity). http://togogenome.org/gene/9541:PARN ^@ http://purl.uniprot.org/uniprot/A0A2K5VR35|||http://purl.uniprot.org/uniprot/A0A7N9DBD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:NID2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKF7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9541:VIM ^@ http://purl.uniprot.org/uniprot/I7GH34 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||Cell membrane|||Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.|||Membrane|||Nucleus matrix|||Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. http://togogenome.org/gene/9541:NPPC ^@ http://purl.uniprot.org/uniprot/A0A2K5WT12|||http://purl.uniprot.org/uniprot/G7PKA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/9541:LOC102138382 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNQ2|||http://purl.uniprot.org/uniprot/G7P2L5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:HSP90B1 ^@ http://purl.uniprot.org/uniprot/Q4R520 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 90 family.|||Endoplasmic reticulum lumen|||Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with AIMP1; regulates its retention in the endoplasmic reticulum. Interacts with OS9 (By similarity). Interacts with CNPY3; this interaction is disrupted in the presence of ATP. Interacts with several TLRs, including TLR4 and TLR9, but not with TLR3 (By similarity). Interacts with MZB1 in a calcium-dependent manner (By similarity). Interacts with METTL23 (By similarity). Interacts with IL1B; the interaction facilitates cargo translocation into the ERGIC (By similarity).|||Melanosome|||Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (By similarity).|||Phosphorylated.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/9541:LOC102136550 ^@ http://purl.uniprot.org/uniprot/A0A2K5WF07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.|||Membrane|||adherens junction|||desmosome http://togogenome.org/gene/9541:ATP1B4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZW9|||http://purl.uniprot.org/uniprot/A0A8J8Y471 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9541:ROMO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQW3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:LHB ^@ http://purl.uniprot.org/uniprot/Q6EV78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.|||Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.|||Secreted http://togogenome.org/gene/9541:EMP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VF24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9541:CPQ ^@ http://purl.uniprot.org/uniprot/A0A2K5W7T5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.|||Endoplasmic reticulum|||Golgi apparatus|||Homodimer. The monomeric form is inactive while the homodimer is active.|||Lysosome|||Secreted http://togogenome.org/gene/9541:ALX4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXF7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:IL2 ^@ http://purl.uniprot.org/uniprot/Q29615 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-2 family.|||Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.|||Secreted http://togogenome.org/gene/9541:PSD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9X8|||http://purl.uniprot.org/uniprot/G7P8F8 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/9541:MORF4L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEY5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TMCC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6S9|||http://purl.uniprot.org/uniprot/A0A2K5U6U3 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9541:SLC1A6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7Q9|||http://purl.uniprot.org/uniprot/G7PZN0|||http://purl.uniprot.org/uniprot/Q4R8D0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:CDK7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTM9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/9541:MARCKSL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHI3 ^@ Similarity ^@ Belongs to the MARCKS family. http://togogenome.org/gene/9541:SLC10A6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9541:OCLN ^@ http://purl.uniprot.org/uniprot/A0A8J8XBB2|||http://purl.uniprot.org/uniprot/G7P7N9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.|||Membrane|||tight junction http://togogenome.org/gene/9541:VAX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMX homeobox family.|||Nucleus http://togogenome.org/gene/9541:XPO4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQV9|||http://purl.uniprot.org/uniprot/A0A2K5UQZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Nucleus http://togogenome.org/gene/9541:RYR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WD17|||http://purl.uniprot.org/uniprot/A0A2K5WD68 ^@ Subcellular Location Annotation ^@ Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9541:MEP1B ^@ http://purl.uniprot.org/uniprot/A0A2K5WR64 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:LOC102122319 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQ18|||http://purl.uniprot.org/uniprot/Q4W8A2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Basolateral cell membrane|||Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Expressed (at protein level) in the kidney.|||Functions as an organic anion/dicarboxylate exchanger that couples organic anion uptake indirectly to the sodium gradient. Transports organic anions such as estrone 3-sulfate (E1S) and urate in exchange for dicarboxylates such as glutarate or ketoglutarate (2-oxoglutarate) (PubMed:15846473). Plays an important role in the excretion of endogenous and exogenous organic anions, especially from the kidney and the brain. Responsible for the transport of prostaglandin E2 (PGE2) and prostaglandin F2(alpha) (PGF2(alpha)) in the basolateral side of the renal tubule. May be involved in the basolateral transport of steviol, a metabolite of the popular sugar substitute stevioside. May participate in the detoxification/ renal excretion of drugs and xenobiotics, such as the histamine H(2)-receptor antagonists fexofenadine and cimetidine, the antibiotic benzylpenicillin (PCG), the anionic herbicide 2,4-dichloro-phenoxyacetate (2,4-D), the diagnostic agent p-aminohippurate (PAH), the antiviral acyclovir (ACV), and the mycotoxin ochratoxin (OTA), by transporting these exogenous organic anions across the cell membrane in exchange for dicarboxylates such as 2-oxoglutarate (PubMed:15846473) (By similarity). Contributes to the renal uptake of potent uremic toxins (indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF)), pravastatin, PCG, E1S and dehydroepiandrosterone sulfate (DHEAS), and is partly involved in the renal uptake of temocaprilat (an angiotensin-converting enzyme (ACE) inhibitor) (By similarity). May contribute to the release of cortisol in the adrenals (By similarity). Involved in one of the detoxification systems on the choroid plexus (CP), removes substrates such as E1S or taurocholate (TC), PCG, 2,4-D and PAH, from the cerebrospinal fluid (CSF) to the blood for eventual excretion in urine and bile (By similarity). Also contributes to the uptake of several other organic compounds such as the prostanoids prostaglandin E(2) and prostaglandin F(2-alpha), L-carnitine, and the therapeutic drugs allopurinol, 6-mercaptopurine (6-MP) and 5-fluorouracil (5-FU) (By similarity). Mediates the transport of PAH, PCG, and the statins pravastatin and pitavastatin, from the cerebrum into the blood circulation across the blood-brain barrier (BBB). In summary, plays a role in the efflux of drugs and xenobiotics, helping reduce their undesired toxicological effects on the body (By similarity). http://togogenome.org/gene/9541:C10H22orf39 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0N2 ^@ Similarity ^@ Belongs to the UPF0545 family. http://togogenome.org/gene/9541:POLRMT ^@ http://purl.uniprot.org/uniprot/A0A2K5UVW4 ^@ Function|||Similarity ^@ Belongs to the phage and mitochondrial RNA polymerase family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/9541:TMEM97 ^@ http://purl.uniprot.org/uniprot/Q4R8A8 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TMEM97/sigma-2 receptor family.|||Interacts with NPC1.|||Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.|||Nucleus membrane|||Rough endoplasmic reticulum membrane|||Sigma receptors are classified into two subtypes (Sigma-1 and Sigma-2) based on their different pharmacological profile. Sigma-2 receptors are identified by radioligand-binding studies as a binding site with high affinity for di-o-tolylguanidine (DTG) and haloperidol. http://togogenome.org/gene/9541:SERINC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9541:SLC9A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VT10 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Interacts with CHP1 and CHP2.|||Membrane http://togogenome.org/gene/9541:ETFDH ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4W4|||http://purl.uniprot.org/uniprot/G7P6H5 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/9541:GORASP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X944 ^@ Similarity ^@ Belongs to the GORASP family. http://togogenome.org/gene/9541:RRAGC ^@ http://purl.uniprot.org/uniprot/A0A2K5V0N9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9541:ELOVL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2R8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL2 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9541:GHSR ^@ http://purl.uniprot.org/uniprot/A0A2K5WND3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). http://togogenome.org/gene/9541:HABP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHY8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:CBX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X776 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PELI3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKX1|||http://purl.uniprot.org/uniprot/A0A2K5TKX7 ^@ Function|||Similarity ^@ Belongs to the pellino family.|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. http://togogenome.org/gene/9541:THY1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4H6|||http://purl.uniprot.org/uniprot/G7PPB4 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.|||Membrane http://togogenome.org/gene/9541:ACLY ^@ http://purl.uniprot.org/uniprot/A0A2K5TWJ2|||http://purl.uniprot.org/uniprot/A0A2K5TWK6 ^@ Function|||Similarity|||Subunit ^@ Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.|||Homotetramer.|||In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.|||In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. http://togogenome.org/gene/9541:ZDHHC13 ^@ http://purl.uniprot.org/uniprot/Q4R690 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Interacts (via ANK repeats) with CLIP3. Interacts (via ANK repeats) with DNAJC5 (via C-terminus). Interacts (via ANK repeats) with HTT. Interacts (via ANK repeats) with MAP6. Interacts (via ANK repeats) with SNAP23. Interacts (via ANK repeats) with SNAP25. May interact (via ANK repeats) with SPRED2.|||Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Palmitoyltransferase for HTT and GAD2. May play a role in Mg(2+) transport.|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:CWC27 ^@ http://purl.uniprot.org/uniprot/Q4R713 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.|||Belongs to the cyclophilin-type PPIase family.|||Despite the fact that it belongs to the cyclophilin-type PPIase family, it has probably no peptidyl-prolyl cis-trans isomerase activity.|||Nucleus|||Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well-formed active site but still cannot catalyze the branching reaction and is composed at least of 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Recruited during early steps of activated spliceosome B maturation, it is probably one of the first proteins released from this complex as he matures to the spliceosome C complex. http://togogenome.org/gene/9541:SYNJ1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ31|||http://purl.uniprot.org/uniprot/A0A2K5UJ57|||http://purl.uniprot.org/uniprot/A0A2K5UJ63|||http://purl.uniprot.org/uniprot/A0A2K5UJ78 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/9541:TACSTD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UE71 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPCAM family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:VDAC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic mitochondrial porin family.|||Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.|||Interacts with ARMC12 in a TBC1D21-dependent manner.|||Mitochondrion outer membrane http://togogenome.org/gene/9541:C1D ^@ http://purl.uniprot.org/uniprot/A0A8J8XV92|||http://purl.uniprot.org/uniprot/G7NZK5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the C1D family.|||Cytoplasm|||Monomer and homodimer.|||Nucleus|||Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.|||nucleolus http://togogenome.org/gene/9541:MRTO4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V748 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the pre-60S ribosomal particle.|||Belongs to the universal ribosomal protein uL10 family.|||Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9541:DEGS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ07 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9541:ARL8B ^@ http://purl.uniprot.org/uniprot/A0A2K5UBD4|||http://purl.uniprot.org/uniprot/A0A7N9CGD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Synapse|||axon|||spindle http://togogenome.org/gene/9541:UGDH ^@ http://purl.uniprot.org/uniprot/A0A2K5WLS0|||http://purl.uniprot.org/uniprot/G7P5F7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.|||Homohexamer.|||Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. http://togogenome.org/gene/9541:LOC102121606 ^@ http://purl.uniprot.org/uniprot/Q14T89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 11 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9541:SLC15A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBU9 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. http://togogenome.org/gene/9541:MDH2 ^@ http://purl.uniprot.org/uniprot/Q4R568 ^@ Activity Regulation|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation is enhanced after treatment either with trichostin A (TCA) or with nicotinamide (NAM) with the appearance of tri- and tetraacetylations. Glucose also increases acetylation.|||Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Enzyme activity is enhanced by acetylation.|||Homodimer.|||Mitochondrion matrix http://togogenome.org/gene/9541:SLC12A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTC3|||http://purl.uniprot.org/uniprot/A0A2K5WTN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9541:ZRANB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9B9|||http://purl.uniprot.org/uniprot/A0A2K5W9D6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZRANB2 family.|||Nucleus|||Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection. http://togogenome.org/gene/9541:ACADSB ^@ http://purl.uniprot.org/uniprot/Q4R4S2 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9541:SAXO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5E5|||http://purl.uniprot.org/uniprot/Q4R7D3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with microtubules via the Mn regions.|||Belongs to the FAM154 family.|||May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature.|||The Mn regions are involved in microtubule-binding and stabilization at low temperature. They are required and sufficient for cilium targeting.|||The N-terminal region (residues 1-29) might play a role in centriole retention.|||centriole|||centrosome|||cilium axoneme|||cilium basal body|||flagellum axoneme http://togogenome.org/gene/9541:SPTY2D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKW5|||http://purl.uniprot.org/uniprot/G7PQL1 ^@ Similarity ^@ Belongs to the SPT2 family. http://togogenome.org/gene/9541:CSNK1A1L ^@ http://purl.uniprot.org/uniprot/A0A2K5VAN7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:SERPINC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYN7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the serpin family.|||Forms protease inhibiting heterodimer with TMPRSS7.|||extracellular space http://togogenome.org/gene/9541:MFSD8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAV3|||http://purl.uniprot.org/uniprot/A0A2K5VAW8|||http://purl.uniprot.org/uniprot/A0A2K5VB08|||http://purl.uniprot.org/uniprot/A0A2K5VB41|||http://purl.uniprot.org/uniprot/G8F4L8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:UTP6 ^@ http://purl.uniprot.org/uniprot/I7G6J7 ^@ Similarity ^@ Belongs to the UTP6 family. http://togogenome.org/gene/9541:RNF7 ^@ http://purl.uniprot.org/uniprot/A0A7N9CCY2 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/9541:ASB15 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ56|||http://purl.uniprot.org/uniprot/G7P0J8 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:AFF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIA6|||http://purl.uniprot.org/uniprot/A0A2K5WIA7 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/9541:CCNT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJJ9|||http://purl.uniprot.org/uniprot/A0A8J8XC66|||http://purl.uniprot.org/uniprot/G7PN36 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9541:DRD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UER3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CYP17A1 ^@ http://purl.uniprot.org/uniprot/G7PDV6|||http://purl.uniprot.org/uniprot/Q2XVA1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).|||Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||Microsome membrane|||Regulated predominantly by intracellular cAMP levels. The 17,20-lyase activity is stimulated by cytochrome b5, which acts as an allosteric effector increasing the Vmax of the lyase activity. http://togogenome.org/gene/9541:FAM3D ^@ http://purl.uniprot.org/uniprot/A0A7N9CBG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9541:TLE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/9541:GALNT9 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUR1|||http://purl.uniprot.org/uniprot/Q9GM01 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Does not glycosylate apomucin or SDC3.|||Golgi apparatus membrane|||Membrane|||The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.|||There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. http://togogenome.org/gene/9541:NAV2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYX2|||http://purl.uniprot.org/uniprot/A0A2K5TYZ0 ^@ Similarity ^@ Belongs to the Nav/unc-53 family. http://togogenome.org/gene/9541:ERP29 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDP8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Does not seem to be a disulfide isomerase.|||Endoplasmic reticulum lumen|||Homodimer.|||Melanosome http://togogenome.org/gene/9541:API5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJH3|||http://purl.uniprot.org/uniprot/G7PQD5 ^@ Similarity ^@ Belongs to the API5 family. http://togogenome.org/gene/9541:LSM5 ^@ http://purl.uniprot.org/uniprot/A0A7N9D8I4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. http://togogenome.org/gene/9541:TXK ^@ http://purl.uniprot.org/uniprot/A0A2K5X607 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9541:ATG4C ^@ http://purl.uniprot.org/uniprot/A0A8J8YN27|||http://purl.uniprot.org/uniprot/G7NW13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9541:ETV1 ^@ http://purl.uniprot.org/uniprot/I7GHU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:ZCCHC8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VS07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZCCHC8 family.|||nucleoplasm http://togogenome.org/gene/9541:FOXA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR04|||http://purl.uniprot.org/uniprot/A0A7N9CHB5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MCM3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWF4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9541:CDK16 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZN1 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9541:C14H11orf49 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLS8|||http://purl.uniprot.org/uniprot/A0A2K5WLV9|||http://purl.uniprot.org/uniprot/Q4R5A4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSTPP1 family.|||Interacts with PCM1. Interacts with TTLL1, TPGS1, TPGS2 and LRRC49; the interactions link CSTPP1 to the complex TPGC. Binds to alpha-tubulin.|||Regulator of the tubulin polyglutamylase complex (TPGC) that controls cytoskeletal organization, nuclear shape, and cilium disassembly by balancing microtubule and actin assembly. Regulates the assembly and stability of the TPGC and thereby modulates polyglutamylation of the microtubule, which antagonizes MAP4 binding.|||centriolar satellite|||cytoskeleton http://togogenome.org/gene/9541:GPNMB ^@ http://purl.uniprot.org/uniprot/A0A2K5TPL8 ^@ Similarity ^@ Belongs to the PMEL/NMB family. http://togogenome.org/gene/9541:PARP10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQM7 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9541:S100A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WB64 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9541:LOC102139994 ^@ http://purl.uniprot.org/uniprot/A0A2K5VY81 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9541:TSEN15 ^@ http://purl.uniprot.org/uniprot/A0A2K5U572|||http://purl.uniprot.org/uniprot/A0A2K5U5A3 ^@ Similarity ^@ Belongs to the SEN15 family. http://togogenome.org/gene/9541:ING4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7V5|||http://purl.uniprot.org/uniprot/G8F3S4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9541:TSHZ2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XNW7|||http://purl.uniprot.org/uniprot/G7PFZ9 ^@ Similarity ^@ Belongs to the teashirt C2H2-type zinc-finger protein family. http://togogenome.org/gene/9541:RAD9A ^@ http://purl.uniprot.org/uniprot/A0A2K5WVB6|||http://purl.uniprot.org/uniprot/Q4R5X9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the rad9 family.|||Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity (By similarity).|||Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of RAD9A, RAD1 and HUS1. The 9-1-1 complex associates with LIG1, POLB, FEN1, RAD17, HDAC1, RPA1 and RPA2. The 9-1-1 complex associates with the RAD17-RFC complex. RAD9A interacts with BCL2L1, FEN1, PRKCD, RAD9B, HUS1, RAD1, ABL1, RPA1, ATAD5 and RPA2. Interacts with DNAJC7 and RHNO1 (By similarity).|||Constitutively phosphorylated on serine and threonine amino acids in absence of DNA damage. Hyperphosphorylated by PRKCD and ABL1 upon DNA damage. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex (By similarity).|||Nucleus http://togogenome.org/gene/9541:STKLD1 ^@ http://purl.uniprot.org/uniprot/Q4R793 ^@ Caution|||Domain|||Similarity ^@ Asn-157 is present instead of the conserved Asp which is expected to be an active site residue.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.|||The protein kinase domain is predicted to be catalytically inactive. http://togogenome.org/gene/9541:NCL ^@ http://purl.uniprot.org/uniprot/Q4R4J7 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Component of the SWAP complex that consists of NPM1, NCL/nucleolin, PARP1 and SWAP70. Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin. Interacts with AICDA. Interacts with APTX. Interacts with C1QBP. Interacts with ERBB4. Interacts (via C-terminus) with FMR1 isoform 6 (via N-terminus). Interacts with GZF1; this interaction is important for nucleolar localization of GZF1. Interacts with NSUN2. Interacts with NVL. Interacts (via N-terminus domain) with SETX. Interacts (via RRM1 and C-terminal RRM4/Arg/Gly-rich domains) with TERT; the interaction is important for nucleolar localization of TERT. Interacts with WDR46. Interacts with ZFP36. Interacts with LRRC34. Interacts with RRP1B. Interacts with HNRNPU; this interaction occurs during mitosis. Interacts with RIOK1; RIOK1 recruits NCL to PRMT5 for symmetrically methylation (By similarity). Interacts with ZBTB7B (By similarity). Interacts with MDK; this interaction promotes NCL clustering and lateral movements of this complex into lipid rafts leading to MDK internalization (By similarity). Interacts with HDGF (By similarity). Interacts with ALKBH2.|||Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity).|||Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).|||Symmetrically methylated by PRMT5 (By similarity).|||nucleolus http://togogenome.org/gene/9541:PPARD ^@ http://purl.uniprot.org/uniprot/A0A2K5W3V1|||http://purl.uniprot.org/uniprot/G7P2V1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:GDF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8P6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:RSPH3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XMF0|||http://purl.uniprot.org/uniprot/Q4R672 ^@ Similarity ^@ Belongs to the flagellar radial spoke RSP3 family. http://togogenome.org/gene/9541:ALG12 ^@ http://purl.uniprot.org/uniprot/A0A2K5X123 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.|||Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:KCNN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZW7|||http://purl.uniprot.org/uniprot/A0A2K5X025 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:KATNA1 ^@ http://purl.uniprot.org/uniprot/G8F473|||http://purl.uniprot.org/uniprot/Q4R407 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit (By similarity). Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM (By similarity) Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42 (By similarity). Interacts with KATNB1 and KATNBL1 (By similarity). Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches (By similarity).|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||Cytoplasm|||Midbody|||Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.|||The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.|||Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.|||centrosome|||spindle|||spindle pole http://togogenome.org/gene/9541:SPRY1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCW3|||http://purl.uniprot.org/uniprot/G7P685 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sprouty family.|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:HK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TME5|||http://purl.uniprot.org/uniprot/A0A2K5TME6 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9541:EMC2 ^@ http://purl.uniprot.org/uniprot/G7PCI1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC2 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. http://togogenome.org/gene/9541:NDUFB7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGE4|||http://purl.uniprot.org/uniprot/G7PZM0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB7 subunit family.|||Complex I is composed of 45 different subunits.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9541:CCNF ^@ http://purl.uniprot.org/uniprot/A0A2K5X3Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family.|||centriole|||perinuclear region http://togogenome.org/gene/9541:HAT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNQ2|||http://purl.uniprot.org/uniprot/A0A8J8YED4|||http://purl.uniprot.org/uniprot/G7PKT8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HAT1 family.|||Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.|||Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). http://togogenome.org/gene/9541:SLC25A5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4J6|||http://purl.uniprot.org/uniprot/A0A7N9CAS1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9541:LOC102120735 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMY4 ^@ Function|||Similarity ^@ Belongs to the SSX family.|||Could act as a modulator of transcription. http://togogenome.org/gene/9541:CYP3A43 ^@ http://purl.uniprot.org/uniprot/B8K1T0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:GSX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WM55 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:GPR183 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIV2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:PDIK1L ^@ http://purl.uniprot.org/uniprot/A0A2K5VL47|||http://purl.uniprot.org/uniprot/A0A7N9CFE3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:CCT3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YRI3|||http://purl.uniprot.org/uniprot/G7NV87|||http://purl.uniprot.org/uniprot/Q25QN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.|||Cytoplasm http://togogenome.org/gene/9541:GRM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQG4|||http://purl.uniprot.org/uniprot/A0A8J8Y634|||http://purl.uniprot.org/uniprot/G7NZX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ERF ^@ http://purl.uniprot.org/uniprot/A0A2K5VB34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:RP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3D3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.|||Belongs to the TBCC family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PROK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMD6|||http://purl.uniprot.org/uniprot/G7NW42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/9541:MEGF11 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMM6|||http://purl.uniprot.org/uniprot/A0A2K5TMN2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:HSPA8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNF9 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9541:LOC101926364 ^@ http://purl.uniprot.org/uniprot/A0A2K5UA25|||http://purl.uniprot.org/uniprot/I7GNR1 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9541:IFI27 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/9541:SPACA4 ^@ http://purl.uniprot.org/uniprot/G7PY25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPACA4/bouncer family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:OPN1LW ^@ http://purl.uniprot.org/uniprot/Q9XSX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/9541:NCBP2L ^@ http://purl.uniprot.org/uniprot/G7Q3F0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRM NCBP2 family.|||Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.|||Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.|||Nucleus http://togogenome.org/gene/9541:FKBP5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XA78|||http://purl.uniprot.org/uniprot/G7P3A6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MMP17 ^@ http://purl.uniprot.org/uniprot/A0A2K5UV35 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9541:CHRM5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UF81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/9541:GLP1R ^@ http://purl.uniprot.org/uniprot/F8V479 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ERRFI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNH5|||http://purl.uniprot.org/uniprot/G7NTD0 ^@ Subcellular Location Annotation ^@ Membrane|||Nucleus http://togogenome.org/gene/9541:ZSCAN21 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYU1|||http://purl.uniprot.org/uniprot/G7P0C2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:IL19 ^@ http://purl.uniprot.org/uniprot/A0A2K5W342 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9541:TNR ^@ http://purl.uniprot.org/uniprot/A0A2K5TRP8|||http://purl.uniprot.org/uniprot/A0A2K5TRR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family.|||extracellular matrix http://togogenome.org/gene/9541:AQP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ACSL4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YEM6|||http://purl.uniprot.org/uniprot/G7Q3G4 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9541:CCNJ ^@ http://purl.uniprot.org/uniprot/A0A2K5WK04|||http://purl.uniprot.org/uniprot/G7PDM7 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9541:TAS2R40 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9541:SPAST ^@ http://purl.uniprot.org/uniprot/A0A2K5WXC4|||http://purl.uniprot.org/uniprot/A0A2K5WXC8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches.|||Allosteric enzyme with a cooperative mechanism; at least two neighbor subunits influence each other strongly in spastin hexamers. Microtubule binding promotes cooperative interactions among spastin subunits.|||Belongs to the AAA ATPase family. Spastin subfamily.|||Cytoplasm|||Endoplasmic reticulum|||Homohexamer. Mostly monomeric, but assembles into hexameric structure for short periods of time. Oligomerization seems to be a prerequisite for catalytic activity. Binding to ATP in a cleft between two adjacent subunits stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer adopts a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with SSNA1. Interacts with ATL1. Interacts with RTN1. Interacts with ZFYVE27. Interacts with REEP1. Interacts (via MIT domain) with IST1.|||Membrane|||Midbody|||Nucleus|||axon|||centrosome|||cytoskeleton|||perinuclear region|||spindle http://togogenome.org/gene/9541:WARS2 ^@ http://purl.uniprot.org/uniprot/A0A7N9IG81|||http://purl.uniprot.org/uniprot/G7NX63 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:ACTL6A ^@ http://purl.uniprot.org/uniprot/A0A2K5UP87 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:VPS26B ^@ http://purl.uniprot.org/uniprot/A0A8J8XCF9|||http://purl.uniprot.org/uniprot/G7PPW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS26 family.|||Endosome http://togogenome.org/gene/9541:MALSU1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHP6 ^@ Similarity ^@ Belongs to the Iojap/RsfS family. http://togogenome.org/gene/9541:COQ4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYR9|||http://purl.uniprot.org/uniprot/I7GI65 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ4 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:DYNLT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8A7 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9541:RPSA ^@ http://purl.uniprot.org/uniprot/I7G7S3 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/9541:NEK11 ^@ http://purl.uniprot.org/uniprot/Q8WNU8 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autorepressed by intramolecular binding of the C-terminus which dissociates following phosphorylation by NEK2. Activated in response to DNA damage. Inhibited by zinc.|||Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.|||Interacts with NEK2.|||Nucleus|||Phosphorylated by NEK2. Phosphorylation at Ser-273 is important for its activation.|||Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.|||nucleolus http://togogenome.org/gene/9541:CASP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYW8 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9541:TDRD7 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8A7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TDRD7 family.|||Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.|||Cytoplasm|||Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1. http://togogenome.org/gene/9541:LOC101866379 ^@ http://purl.uniprot.org/uniprot/I7GK95 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. http://togogenome.org/gene/9541:GUF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMR1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. LepA subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion inner membrane|||Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. http://togogenome.org/gene/9541:IRF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5R1|||http://purl.uniprot.org/uniprot/A0A2K5V5U4|||http://purl.uniprot.org/uniprot/G8F5X0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:RHBDL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2Z1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC101866254 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRM2|||http://purl.uniprot.org/uniprot/G7NY87 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:ENTPD6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSX2 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9541:GPR12 ^@ http://purl.uniprot.org/uniprot/A0A2K5TP16|||http://purl.uniprot.org/uniprot/G7PVW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102126903 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STK11IP family.|||Cytoplasm http://togogenome.org/gene/9541:LOC102138242 ^@ http://purl.uniprot.org/uniprot/A0A2K5UD58 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:RDH12 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8Z4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:LOC102134053 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWN3 ^@ Similarity ^@ Belongs to the histone H2B family. http://togogenome.org/gene/9541:TYW3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAB5 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. http://togogenome.org/gene/9541:KCNV1 ^@ http://purl.uniprot.org/uniprot/G7PCI9|||http://purl.uniprot.org/uniprot/Q9GKU7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.|||Cell membrane|||Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1 (By similarity).|||Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.|||Membrane|||Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (By similarity).|||Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.|||The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. http://togogenome.org/gene/9541:ZDHHC9 ^@ http://purl.uniprot.org/uniprot/A0A8J8XH94|||http://purl.uniprot.org/uniprot/G7Q3N4 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:SLC29A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6E0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/9541:PPP1R11 ^@ http://purl.uniprot.org/uniprot/G7P3V9|||http://purl.uniprot.org/uniprot/I7G3X7 ^@ Subunit ^@ Interacts with TLR2 and UBE2D2. http://togogenome.org/gene/9541:VPS37B ^@ http://purl.uniprot.org/uniprot/A0A2K5WZU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9541:BAZ1B ^@ http://purl.uniprot.org/uniprot/A0A2K5UR31 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:AP2A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZM7|||http://purl.uniprot.org/uniprot/A0A2K5VZV3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).|||Belongs to the adaptor complexes large subunit family.|||Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.|||coated pit http://togogenome.org/gene/9541:MPI ^@ http://purl.uniprot.org/uniprot/Q8HXX2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9541:TPO ^@ http://purl.uniprot.org/uniprot/A0A2K5TRL1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:KCNH5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZ53|||http://purl.uniprot.org/uniprot/G7PAH7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CPN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDJ6 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9541:LOC102137032 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ02 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/9541:RPP14 ^@ http://purl.uniprot.org/uniprot/A0A2K5WD56 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family. http://togogenome.org/gene/9541:TNFSF11 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2X5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Homotrimer.|||Membrane|||Secreted http://togogenome.org/gene/9541:CACNB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYA2|||http://purl.uniprot.org/uniprot/A0A2K5TYD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||Membrane|||sarcolemma http://togogenome.org/gene/9541:PFKFB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8T7|||http://purl.uniprot.org/uniprot/A0A2K5V8Y5|||http://purl.uniprot.org/uniprot/A0A2K5V903|||http://purl.uniprot.org/uniprot/A0A2K5V967|||http://purl.uniprot.org/uniprot/I7GP97 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9541:NAP1L4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0L3|||http://purl.uniprot.org/uniprot/A0A2K5U0P8|||http://purl.uniprot.org/uniprot/A0A2K5U0Q7 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9541:CSNK1D ^@ http://purl.uniprot.org/uniprot/A0A2K5WW40|||http://purl.uniprot.org/uniprot/A0A2K5WW54|||http://purl.uniprot.org/uniprot/I7G4F6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:RSPO3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTQ7 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9541:LYPD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0X5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102127013 ^@ http://purl.uniprot.org/uniprot/O97951 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Expressed in liver, prostate, kidney, testis, adrenal, bile duct, bladder, colon, small intestine, cerebellum and pancreas.|||Microsome membrane|||UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward 3-hydroxyandrogens. It is principally active on C19 steroids having a hydroxyl group at position 3-alpha of the steroid molecule and also active on planar phenols and bile acids. http://togogenome.org/gene/9541:HAS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NodC/HAS family.|||Endoplasmic reticulum membrane|||Lysosome|||Membrane http://togogenome.org/gene/9541:METTL15 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIM8|||http://purl.uniprot.org/uniprot/Q4R7L2 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. RsmH family. http://togogenome.org/gene/9541:SUSD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAB9|||http://purl.uniprot.org/uniprot/A0A2K5VAC0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:CYP2A26 ^@ http://purl.uniprot.org/uniprot/E0XJT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:MDGA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1X5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:EEF1B2 ^@ http://purl.uniprot.org/uniprot/I7GHJ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EF-1-beta/EF-1-delta family.|||EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.|||EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. http://togogenome.org/gene/9541:PABPC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWH5|||http://purl.uniprot.org/uniprot/A0A2K5WWI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/9541:LOC102116763 ^@ http://purl.uniprot.org/uniprot/A0A8J8YGQ3|||http://purl.uniprot.org/uniprot/G7Q2M1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9541:DCLK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVN1|||http://purl.uniprot.org/uniprot/A0A2K5TVQ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9541:NPVF ^@ http://purl.uniprot.org/uniprot/A0A2K5V6N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||Secreted http://togogenome.org/gene/9541:MATN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0B0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:STARD3NL ^@ http://purl.uniprot.org/uniprot/A0A2K5VI00|||http://purl.uniprot.org/uniprot/A0A2K5VI54|||http://purl.uniprot.org/uniprot/I7G8W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9541:LGR5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIL2|||http://purl.uniprot.org/uniprot/G7PI19 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:IFT46 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPG7|||http://purl.uniprot.org/uniprot/A0A2K5VPL8|||http://purl.uniprot.org/uniprot/G8F447 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT46 family.|||cilium|||cilium basal body http://togogenome.org/gene/9541:DLGAP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLX0 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9541:EARS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2T6|||http://purl.uniprot.org/uniprot/Q4R4F1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Mitochondrion matrix http://togogenome.org/gene/9541:LIMK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXI2|||http://purl.uniprot.org/uniprot/A0A2K5VXR7|||http://purl.uniprot.org/uniprot/G8F3C7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/9541:LOC102127670 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LPCAT3 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2P3|||http://purl.uniprot.org/uniprot/G7PJP3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:DCT ^@ http://purl.uniprot.org/uniprot/A0A2K5VPR3|||http://purl.uniprot.org/uniprot/A0A8J8XD96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/9541:MOAP1 ^@ http://purl.uniprot.org/uniprot/Q95KI4 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNMA family.|||Extracellular vesicle membrane|||Homodimer. Under normal circumstances, held in an inactive conformation by an intramolecular interaction. Interacts with BAX. Binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction and allows further binding to BAX. Binds also to BCL2 and BCLX. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization. Interacts with TRIM39 (By similarity). Interacts with RASSF6 (By similarity). Interacts with ATG8 proteins MAP1LC3A, MAP1LC3B and MAP1LC3C. Does not interact with ATG8 proteins GABARAPL1, GABARAPL2 and GABARAP. Interacts with SQSTM1; promoting dissociation of SQSTM1 inclusion bodies that sequester KEAP1 (By similarity).|||Mitochondrion outer membrane|||Retrotransposon-derived protein that forms virion-like capsids (By similarity). Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis. Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins. Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex (By similarity).|||The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction.|||The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins MAP1LC3A, MAP1LC3B and MAP1LC3C.|||The protein is evolutionarily related to retrotransposon Gag proteins: it contains the capsid (CA)subdomain of gag.|||Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1, this modification is inhibited by TRIM39.|||cytosol http://togogenome.org/gene/9541:FAM83G ^@ http://purl.uniprot.org/uniprot/A0A2K5VLI2 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9541:SYNE4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ94 ^@ Similarity ^@ Belongs to the nesprin family. http://togogenome.org/gene/9541:LYVE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWG3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PGPEP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UED9|||http://purl.uniprot.org/uniprot/A0A7N9CFL0|||http://purl.uniprot.org/uniprot/A0A8J8Y4Q6|||http://purl.uniprot.org/uniprot/G7PWZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C15 family.|||Cytoplasm|||Removes 5-oxoproline from various penultimate amino acid residues except L-proline. http://togogenome.org/gene/9541:SPRY2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMH2|||http://purl.uniprot.org/uniprot/A0A8J8XQS4|||http://purl.uniprot.org/uniprot/Q2PFN5 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (By similarity).|||Belongs to the sprouty family.|||Cleaved at Pro-144 by the prolyl endopeptidase FAP (seprase) activity (in vitro).|||Forms heterodimers with SPRY1 (By similarity). Forms a tripartite complex containing GAB1, METTL13 and SPRY2 (By similarity). Within the complex interacts with METTL13 (By similarity). Interacts with RAF1 (By similarity). Interacts (via C-terminus) with TESK1 (via C-terminus); the interaction disrupts SPRY2 interaction with GRB2, potentially via disruption of SPRY2 serine dephosphorylation (By similarity). Interacts with PPP2R1A/PP2A-A and PPP2CA/PP2A-C; the interaction with PPP2CA/PP2A-C is inhibited by interaction with TESK1, possibly by vesicular sequestration of SPRY2 (By similarity). Inhibition of the interaction with the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme results in loss of PP2A-mediated dephosphorylation, resulting in the loss of SPRY2 interaction with GRB2 (By similarity). Interacts with GRB2 (By similarity). Interacts with CBL/C-CBL; the interaction inhibits CBL-mediated ubiquitination of EGFR (By similarity). Interacts (via C-terminus) with CAV1 (via C-terminus) (By similarity).|||The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.|||cytoskeleton|||ruffle membrane http://togogenome.org/gene/9541:NPY ^@ http://purl.uniprot.org/uniprot/A0A2K5VHQ4|||http://purl.uniprot.org/uniprot/G7P0Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/9541:CD53 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6N2|||http://purl.uniprot.org/uniprot/G7NW46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:PPY ^@ http://purl.uniprot.org/uniprot/A0A2K5TNU2|||http://purl.uniprot.org/uniprot/G7PUY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.|||Secreted http://togogenome.org/gene/9541:SLC34A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWI2 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:AREG ^@ http://purl.uniprot.org/uniprot/A0A2K5U4V6|||http://purl.uniprot.org/uniprot/G7P5K2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:FAM241A ^@ http://purl.uniprot.org/uniprot/A0A2K5X8Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM241 family.|||Membrane http://togogenome.org/gene/9541:LPXN ^@ http://purl.uniprot.org/uniprot/A0A2K5U3C6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paxillin family.|||Cell membrane|||Cytoplasm|||Nucleus|||The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR.|||Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN).|||focal adhesion|||perinuclear region|||podosome http://togogenome.org/gene/9541:RAD52 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9U3 ^@ Similarity ^@ Belongs to the RAD52 family. http://togogenome.org/gene/9541:LOC102136852 ^@ http://purl.uniprot.org/uniprot/G8F601 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9541:MRPL32 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUN2|||http://purl.uniprot.org/uniprot/I7GL70 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/9541:SENP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX84|||http://purl.uniprot.org/uniprot/A0A2K5TX88|||http://purl.uniprot.org/uniprot/A0A2K5TX95|||http://purl.uniprot.org/uniprot/Q8WP32 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C48 family.|||Interacts with CCAR2.|||Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.|||nucleolus http://togogenome.org/gene/9541:GNG11 ^@ http://purl.uniprot.org/uniprot/G7P1D1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9541:PLK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3U2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/9541:LOC102144907 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGW3|||http://purl.uniprot.org/uniprot/G7Q2G5 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9541:DPY19L3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VH86|||http://purl.uniprot.org/uniprot/G7PX56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/9541:KCTD16 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWN2 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:SART3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYB8|||http://purl.uniprot.org/uniprot/A0A2K5WYD1|||http://purl.uniprot.org/uniprot/G7PI53 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/9541:SLC9A6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9541:RAPGEF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ56|||http://purl.uniprot.org/uniprot/A0A2K5VJE9|||http://purl.uniprot.org/uniprot/A0A2K5VJJ4|||http://purl.uniprot.org/uniprot/A0A2K5VJK6|||http://purl.uniprot.org/uniprot/A0A7N9CTX2|||http://purl.uniprot.org/uniprot/A0A7N9CY37|||http://purl.uniprot.org/uniprot/G8F2H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAPGEF2 family.|||Cell junction|||Endosome|||Late endosome|||perinuclear region http://togogenome.org/gene/9541:IL26 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5V2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9541:SEC61A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:ADAMTS17 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCQ1|||http://purl.uniprot.org/uniprot/A0A2K5UCQ2 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:TMEM225 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYG3|||http://purl.uniprot.org/uniprot/G7PPD7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:APOLD1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CPN4 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9541:SYBU ^@ http://purl.uniprot.org/uniprot/A0A2K5WIU4|||http://purl.uniprot.org/uniprot/A0A2K5WIU6|||http://purl.uniprot.org/uniprot/A0A2K5WIV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PDE6A ^@ http://purl.uniprot.org/uniprot/A0A2K5X2J2|||http://purl.uniprot.org/uniprot/G7P8N7 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:C5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1T1 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:IDUA ^@ http://purl.uniprot.org/uniprot/A0A2K5UZF4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 39 family. http://togogenome.org/gene/9541:LOC102125919 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6B3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.|||centrosome http://togogenome.org/gene/9541:PSMD4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8R1 ^@ Similarity ^@ Belongs to the proteasome subunit S5A family. http://togogenome.org/gene/9541:NT5DC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2E0 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/9541:C3H7orf25 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKP3|||http://purl.uniprot.org/uniprot/A0A7N9D8R8 ^@ Similarity ^@ Belongs to the UPF0415 family. http://togogenome.org/gene/9541:NIT2 ^@ http://purl.uniprot.org/uniprot/I7G4A5 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/9541:HEXA ^@ http://purl.uniprot.org/uniprot/I7GH12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 20 family.|||Lysosome http://togogenome.org/gene/9541:INTS7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WG24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 7 family.|||Nucleus http://togogenome.org/gene/9541:SPEM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTV9|||http://purl.uniprot.org/uniprot/G7PTH2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GFRA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ28 ^@ Similarity ^@ Belongs to the GDNFR family. http://togogenome.org/gene/9541:KRT2 ^@ http://purl.uniprot.org/uniprot/G7PID3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:PRKCQ ^@ http://purl.uniprot.org/uniprot/A0A2K5WLP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/9541:KLHL40 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTG3 ^@ Similarity|||Subcellular Location Annotation ^@ A band|||Belongs to the KLHL40 family.|||I band http://togogenome.org/gene/9541:MYH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZW8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:LOC102142539 ^@ http://purl.uniprot.org/uniprot/A0A2K5UF00 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:EFNB1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CAH0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:ELP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAP6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. http://togogenome.org/gene/9541:PAX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9541:SEMA4C ^@ http://purl.uniprot.org/uniprot/A0A2K5VV83 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:SLC12A8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TK59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9541:RLN2 ^@ http://purl.uniprot.org/uniprot/G7PSF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.|||Secreted http://togogenome.org/gene/9541:FAM234A ^@ http://purl.uniprot.org/uniprot/A0A2K5U7E8|||http://purl.uniprot.org/uniprot/A0A2K5U7H5|||http://purl.uniprot.org/uniprot/A0A2K5U7J1 ^@ Similarity ^@ Belongs to the FAM234 family. http://togogenome.org/gene/9541:TFF2 ^@ http://purl.uniprot.org/uniprot/A0A7N9D9T8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:SLC25A43 ^@ http://purl.uniprot.org/uniprot/A0A2K5VX89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:BCKDK ^@ http://purl.uniprot.org/uniprot/A0A8J8YQ84|||http://purl.uniprot.org/uniprot/Q95LS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9541:TUBGCP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ67|||http://purl.uniprot.org/uniprot/A0A2K5TQ93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9541:OTOF ^@ http://purl.uniprot.org/uniprot/A0A2K5VJJ6|||http://purl.uniprot.org/uniprot/A0A2K5VJK4 ^@ Similarity ^@ Belongs to the ferlin family. http://togogenome.org/gene/9541:PDP1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CIZ6|||http://purl.uniprot.org/uniprot/A0A7N9D9J9 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9541:PRSS53 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VKOR family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:BOK ^@ http://purl.uniprot.org/uniprot/A0A2K5X835 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane http://togogenome.org/gene/9541:CFAP126 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRH1 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the Flattop family. http://togogenome.org/gene/9541:BMP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6H8|||http://purl.uniprot.org/uniprot/A0A7N9I9M4 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9541:JPH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/9541:KNG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUB5|||http://purl.uniprot.org/uniprot/A0A2K5WUE1 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/9541:IFT20 ^@ http://purl.uniprot.org/uniprot/G7PTW5 ^@ Subcellular Location Annotation ^@ centriole|||cilium|||cis-Golgi network http://togogenome.org/gene/9541:KEG98_p05 ^@ http://purl.uniprot.org/uniprot/C3W4Z3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:KLC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQI2|||http://purl.uniprot.org/uniprot/A0A2K5UQK2|||http://purl.uniprot.org/uniprot/A0A2K5UQN5|||http://purl.uniprot.org/uniprot/A0A2K5UQN9|||http://purl.uniprot.org/uniprot/A0A2K5UQQ6|||http://purl.uniprot.org/uniprot/A0A2K5UR07 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/9541:HAUS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS3 family.|||spindle http://togogenome.org/gene/9541:RABGGTA ^@ http://purl.uniprot.org/uniprot/A0A2K5UCG8 ^@ Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family.|||Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. http://togogenome.org/gene/9541:CAMK1D ^@ http://purl.uniprot.org/uniprot/A0A2K5WZK2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:ATE1 ^@ http://purl.uniprot.org/uniprot/Q2PFX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the R-transferase family.|||Cytoplasm|||Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).|||Monomer. Interacts with LIAT1 (By similarity).|||Nucleus http://togogenome.org/gene/9541:TGFB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZI7|||http://purl.uniprot.org/uniprot/A0A7N9D1Q4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/9541:PCOLCE2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y7D8|||http://purl.uniprot.org/uniprot/G7P007 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:RIF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0S4|||http://purl.uniprot.org/uniprot/A0A2K5V0T1 ^@ Subcellular Location Annotation ^@ Nucleus|||telomere http://togogenome.org/gene/9541:HDHD3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YNL2|||http://purl.uniprot.org/uniprot/G7PRM3 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9541:CD164L2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V420 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane http://togogenome.org/gene/9541:CAPN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIF5|||http://purl.uniprot.org/uniprot/A0A2K5UIG7|||http://purl.uniprot.org/uniprot/Q9GLG7 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by micromolar concentrations of calcium and inhibited by calpastatin.|||Belongs to the glycosyl hydrolase 31 family.|||Belongs to the peptidase C2 family.|||Calcium-regulated non-lysosomal thiol-protease.|||Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53.|||Cytoplasm|||Homodimer.|||Homodimer; via EF-hand domain 4. Interacts with TTN/titin. Interacts with CMYA5; this interaction, which results in CMYA5 proteolysis, may protect CAPN3 from autolysis. Interacts with SIMC1. Interacts with UTP25; the interaction is required for CAPN3 translocation to the nucleolus.|||nucleolus http://togogenome.org/gene/9541:C7H15orf40 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2R8 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/9541:PPM1F ^@ http://purl.uniprot.org/uniprot/A0A2K5X977|||http://purl.uniprot.org/uniprot/A0A7N9D1S3 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9541:MRPL24 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEQ1|||http://purl.uniprot.org/uniprot/G8F6F0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9541:LOC102125912 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-defensin family.|||Secreted http://togogenome.org/gene/9541:RFX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4G0|||http://purl.uniprot.org/uniprot/A0A2K5U4L9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SLU7 ^@ http://purl.uniprot.org/uniprot/Q4R4P2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLU7 family.|||Component of pre-catalytic, catalytic and post-catalytic spliceosomes. Associates with the spliceosome prior to recognition of the 3'-splice site for step II, probably during catalysis of step I.|||Cytoplasm|||Nucleus|||Nucleus speckle|||Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.|||The CCHC-type zinc finger is required to retain the protein within the nucleus and prevent its shuttle back to the cytoplasm via the CRM1 pathway. http://togogenome.org/gene/9541:HTR1F ^@ http://purl.uniprot.org/uniprot/A0A8J8YEW1|||http://purl.uniprot.org/uniprot/G7NZ54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.|||Membrane http://togogenome.org/gene/9541:NIP7 ^@ http://purl.uniprot.org/uniprot/I7GDL3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NIP7 family.|||Interacts with pre-ribosome complex.|||Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/9541:POP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMW6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Component of nuclear RNase P and RNase MRP.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/9541:CPA5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VR26|||http://purl.uniprot.org/uniprot/Q4R7R2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Binds 1 zinc ion per subunit.|||Secreted http://togogenome.org/gene/9541:THUMPD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVW7 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9541:LOC101865400 ^@ http://purl.uniprot.org/uniprot/A5LFV9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:FAM3C ^@ http://purl.uniprot.org/uniprot/A0A2K5VE88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9541:PITX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5I0|||http://purl.uniprot.org/uniprot/A0A2K5X5L8|||http://purl.uniprot.org/uniprot/A0A2K5X624 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9541:EXOSC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP40 family.|||Cytoplasm http://togogenome.org/gene/9541:DYNC1I1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPG5|||http://purl.uniprot.org/uniprot/A0A2K5TSB8|||http://purl.uniprot.org/uniprot/A0A2K5TSF5|||http://purl.uniprot.org/uniprot/A0A8J8XIW1|||http://purl.uniprot.org/uniprot/G7P1B9|||http://purl.uniprot.org/uniprot/Q4R4Q2 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/9541:ARPC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPC5|||http://purl.uniprot.org/uniprot/A0A2K5UPF1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC2 family.|||Cell projection|||Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton|||synaptosome http://togogenome.org/gene/9541:ZNF394 ^@ http://purl.uniprot.org/uniprot/I7GK03 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:WHAMM ^@ http://purl.uniprot.org/uniprot/A0A2K5U9F0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TMEM39A ^@ http://purl.uniprot.org/uniprot/A0A2K5WRG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/9541:CCNYL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U770|||http://purl.uniprot.org/uniprot/A0A2K5U7B6 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/9541:CIAPIN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X645|||http://purl.uniprot.org/uniprot/G7Q179 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion intermembrane space|||Monomer. Interacts with NDOR1. Interacts with CHCHD4.|||Nucleus|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/9541:RPS23 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRR8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Component of the 40S small ribosomal subunit.|||Rough endoplasmic reticulum http://togogenome.org/gene/9541:NEU1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WS75|||http://purl.uniprot.org/uniprot/G8F3W3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/9541:IQCG ^@ http://purl.uniprot.org/uniprot/A0A2K5WFN2|||http://purl.uniprot.org/uniprot/A0A2K5WFU9|||http://purl.uniprot.org/uniprot/Q9GKR7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DRC9 family.|||Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility.|||Component of the nexin-dynein regulatory complex (N-DRC). Interacts (via IQ domain) with CALM when calcium levels are low. Does not interact with CALM in the presence of Ca(2+). Interacts with the HSP70 proteins HSPA1L and HSPA8. May form a complex with CAMK4 and HSP70.|||Cytoplasm|||The IQ domain mediates interaction with calmodulin when cellular Ca(2+) levels are low.|||cilium|||cytoskeleton|||flagellum|||flagellum axoneme http://togogenome.org/gene/9541:MBTPS2 ^@ http://purl.uniprot.org/uniprot/A0A7N9D5H2|||http://purl.uniprot.org/uniprot/A0A8J8XRU4|||http://purl.uniprot.org/uniprot/G7Q2C9 ^@ Similarity ^@ Belongs to the peptidase M50A family. http://togogenome.org/gene/9541:DNAAF6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJR1|||http://purl.uniprot.org/uniprot/G7Q3E5 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9541:MFF ^@ http://purl.uniprot.org/uniprot/A0A2K5X6A5|||http://purl.uniprot.org/uniprot/A0A2K5X6D5|||http://purl.uniprot.org/uniprot/A0A2K5X6D8|||http://purl.uniprot.org/uniprot/A0A2K5X6F5|||http://purl.uniprot.org/uniprot/A0A2K5X6U7|||http://purl.uniprot.org/uniprot/A0A7N9I9D2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tango11 family.|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.|||synaptic vesicle http://togogenome.org/gene/9541:ENPP6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNX3 ^@ Similarity ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. http://togogenome.org/gene/9541:IFI35 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NMI family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9541:CHAC2 ^@ http://purl.uniprot.org/uniprot/A0A7N9D068|||http://purl.uniprot.org/uniprot/A0A8J8XXV5|||http://purl.uniprot.org/uniprot/G7PM72 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/9541:SLC25A12 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4N3|||http://purl.uniprot.org/uniprot/A0A2K5W4N6|||http://purl.uniprot.org/uniprot/A0A2K5W4S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:GABARAPL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5D7|||http://purl.uniprot.org/uniprot/G7PJT4 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9541:IDH3A ^@ http://purl.uniprot.org/uniprot/A0A2K5TMU6|||http://purl.uniprot.org/uniprot/A0A2K5TMV7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/9541:VKORC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U002 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VKOR family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:CASP9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNT6|||http://purl.uniprot.org/uniprot/A0A2K5VNU7 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9541:NOS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWM8 ^@ Similarity ^@ Belongs to the NOS family. http://togogenome.org/gene/9541:LOC102139875 ^@ http://purl.uniprot.org/uniprot/P61251 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS26 family.|||Component of the 40S small ribosomal subunit.|||Cytoplasm|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/9541:LOC102136612 ^@ http://purl.uniprot.org/uniprot/A0A2K5UE17 ^@ Similarity ^@ Belongs to the histone H2B family. http://togogenome.org/gene/9541:DCLRE1C ^@ http://purl.uniprot.org/uniprot/A0A2K5X8W2|||http://purl.uniprot.org/uniprot/E5FGH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9541:TMEM263 ^@ http://purl.uniprot.org/uniprot/I7GII2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM263 family.|||Membrane http://togogenome.org/gene/9541:CTSW ^@ http://purl.uniprot.org/uniprot/A0A2K5TYS6 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9541:TRPV1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3C1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||dendritic spine membrane http://togogenome.org/gene/9541:PTN ^@ http://purl.uniprot.org/uniprot/A0A2K5VRE6|||http://purl.uniprot.org/uniprot/A0A2K5VRF2|||http://purl.uniprot.org/uniprot/A0A2K5VRP8 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/9541:SSMEM1 ^@ http://purl.uniprot.org/uniprot/Q4R309 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:APOA2 ^@ http://purl.uniprot.org/uniprot/G7NXA8|||http://purl.uniprot.org/uniprot/P18656 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the apolipoprotein A2 family.|||May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.|||Monomer. Interacts with NAXE and NDRG1 (By similarity).|||Plasma.|||Secreted http://togogenome.org/gene/9541:PRDM4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWI1 ^@ Function|||Subcellular Location Annotation ^@ May function as a transcription factor involved in cell differentiation.|||Nucleus http://togogenome.org/gene/9541:STK32B ^@ http://purl.uniprot.org/uniprot/A0A2K5WRL0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:TOPORS ^@ http://purl.uniprot.org/uniprot/A0A2K5X8H4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB6 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:DYNLT5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPL7|||http://purl.uniprot.org/uniprot/G7NW29 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9541:GLT8D2 ^@ http://purl.uniprot.org/uniprot/Q4R3U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 8 family.|||Membrane http://togogenome.org/gene/9541:DLL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1M3 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/9541:GPR155 ^@ http://purl.uniprot.org/uniprot/A0A2K5TM64 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ROCK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WB74 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by RHOA binding. Inhibited by Y-27632.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||Homodimer.|||Membrane|||Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. http://togogenome.org/gene/9541:PSMD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0W1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S1 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9541:CYP2C8 ^@ http://purl.uniprot.org/uniprot/P33262 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||By 3-methylcholanthrene (3MC).|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:PPP6C ^@ http://purl.uniprot.org/uniprot/I7G633 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/9541:FOXB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UH33 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CDC42BPA ^@ http://purl.uniprot.org/uniprot/A0A2K5U6C2|||http://purl.uniprot.org/uniprot/A0A2K5U6C8|||http://purl.uniprot.org/uniprot/A0A2K5U6E4|||http://purl.uniprot.org/uniprot/A0A2K5U6F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.|||Cytoplasm|||lamellipodium http://togogenome.org/gene/9541:CCDC25 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAU4|||http://purl.uniprot.org/uniprot/G7PCY9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC25 family.|||Cell membrane|||Endomembrane system|||Interacts (via cytoplasmic region) with ILK. http://togogenome.org/gene/9541:NDST1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYC2|||http://purl.uniprot.org/uniprot/A0A2K5UYH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9541:RPL34 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBG0|||http://purl.uniprot.org/uniprot/A0A2K5UH45 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/9541:SUPT6H ^@ http://purl.uniprot.org/uniprot/A0A8J8XF45|||http://purl.uniprot.org/uniprot/G7PTX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT6 family.|||Nucleus|||Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). http://togogenome.org/gene/9541:FAM172A ^@ http://purl.uniprot.org/uniprot/A0A2K5U8C0|||http://purl.uniprot.org/uniprot/A0A2K5U8D3|||http://purl.uniprot.org/uniprot/A0A2K5U8E0|||http://purl.uniprot.org/uniprot/A0A7N9CCK4|||http://purl.uniprot.org/uniprot/G7P7Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM172 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:ZC2HC1C ^@ http://purl.uniprot.org/uniprot/A0A2K5UFQ8|||http://purl.uniprot.org/uniprot/Q9BGW4 ^@ Similarity ^@ Belongs to the ZC2HC1 family. http://togogenome.org/gene/9541:TRAK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/9541:AZGP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TU41 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9541:GALNT1 ^@ http://purl.uniprot.org/uniprot/G7PWN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:GTPBP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBZ7|||http://purl.uniprot.org/uniprot/A0A2K5UC03 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. http://togogenome.org/gene/9541:BTBD10 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ72|||http://purl.uniprot.org/uniprot/A0A2K5TQ85|||http://purl.uniprot.org/uniprot/A0A2K5TQ90|||http://purl.uniprot.org/uniprot/G7PQP3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:ALX1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YN78|||http://purl.uniprot.org/uniprot/G7PIK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9541:HLX ^@ http://purl.uniprot.org/uniprot/A0A2K5TZZ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ATP6V0B ^@ http://purl.uniprot.org/uniprot/A0A2K5VUK2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9541:OLFML1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZH5|||http://purl.uniprot.org/uniprot/G7PQT9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:VWA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIE7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:KCNA10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGF0|||http://purl.uniprot.org/uniprot/G7NW43 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102125569 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/9541:PLD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8V3 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9541:SNX5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXX6|||http://purl.uniprot.org/uniprot/A0A7N9C732 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/9541:TF ^@ http://purl.uniprot.org/uniprot/A0A2K5UXZ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transferrin family.|||Monomer.|||Secreted|||Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. http://togogenome.org/gene/9541:USP28 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZC2 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9541:LOC101926677 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEW9|||http://purl.uniprot.org/uniprot/A0A7N9DCN7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LIG4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPB9|||http://purl.uniprot.org/uniprot/A0A7N9CEX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/9541:PBX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/9541:TBCCD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WF23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCC family.|||centrosome|||spindle pole http://togogenome.org/gene/9541:CA2 ^@ http://purl.uniprot.org/uniprot/I7GPE6 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9541:IRF5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VH46|||http://purl.uniprot.org/uniprot/G7P0M4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:TPD52L2 ^@ http://purl.uniprot.org/uniprot/Q4R7B8 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9541:VPS25 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8X3 ^@ Similarity ^@ Belongs to the VPS25 family. http://togogenome.org/gene/9541:LOC107126384 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SPATA22 ^@ http://purl.uniprot.org/uniprot/Q95JQ1 ^@ Function|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Chromosome|||Component of a multiprotein complex with MEIOB and RPA2. Interacts with the complex BRME1:HSF2BP:BRCA2.|||Expressed in testis.|||Meiosis-specific protein required for homologous recombination in meiosis I. http://togogenome.org/gene/9541:AP3S2 ^@ http://purl.uniprot.org/uniprot/G7P9F6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Membrane|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. http://togogenome.org/gene/9541:SCD ^@ http://purl.uniprot.org/uniprot/A0A2K5TPH0|||http://purl.uniprot.org/uniprot/G7PDR3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/9541:KCTD7 ^@ http://purl.uniprot.org/uniprot/A0A2K5X953 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:EXOSC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U584 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:PFN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VU17|||http://purl.uniprot.org/uniprot/I7GHA4 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/9541:B3GAT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U331 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:MTF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIX9|||http://purl.uniprot.org/uniprot/I7G9R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/9541:NR5A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6A3|||http://purl.uniprot.org/uniprot/A0A2K5U6B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/9541:FHIP2B ^@ http://purl.uniprot.org/uniprot/A0A2K5VVP7 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/9541:IL7R ^@ http://purl.uniprot.org/uniprot/Q38IC7 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Cell membrane|||N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.|||Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP) (By similarity).|||The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R (By similarity).|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation. http://togogenome.org/gene/9541:TSSK6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPA4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:TFE3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YBY1|||http://purl.uniprot.org/uniprot/G7Q2P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9541:DPF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8E9|||http://purl.uniprot.org/uniprot/G7PPI4 ^@ Similarity ^@ Belongs to the requiem/DPF family. http://togogenome.org/gene/9541:NOX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V091 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:HMGB1 ^@ http://purl.uniprot.org/uniprot/Q4R844 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated on multiple sites upon stimulation with LPS (By similarity). Acetylation on lysine residues in the nuclear localization signals (NLS 1 and NLS 2) leads to cytoplasmic localization and subsequent secretion. Acetylation on Lys-3 results in preferential binding to DNA ends and impairs DNA bending activity (By similarity).|||Belongs to the HMGB family.|||Cell membrane|||Chromosome|||Cytoplasm|||Endoplasmic reticulum-Golgi intermediate compartment|||Endosome|||Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers.|||HMG box 2 mediates pro-inflammatory cytokine-stimulating activity and binding to TLR4. However, not involved in mediating immunogenic activity in the context of apoptosis-induced immune tolerance.|||In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation. Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury. In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy. Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages.|||In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization. Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM. Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE. Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10. Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12. TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2. In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes. Contributes to tumor proliferation by association with ACER/RAGE. Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex. Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism. Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells. In adaptive immunity may be involved in enhancing immunity through activation of effector T-cells and suppression of regulatory T (TReg) cells. In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression. Also reported to limit proliferation of T-cells. Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production. Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106. During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes.|||In vitro cleavage by CASP1 is liberating a HMG box 1-containing peptide which may mediate immunogenic activity; the peptide antagonizes apoptosis-induced immune tolerance. Can be proteolytically cleaved by a thrombin:thrombomodulin complex; reduces binding to heparin and pro-inflammatory activities (By similarity).|||Interacts (fully reduced HMGB1) with CXCL12; probably in a 1:2 ratio involving two molecules of CXCL12, each interacting with one HMG box of HMGB1; inhibited by glycyrrhizin. Associates with the TLR4:LY96 receptor complex. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Interacts (in cytoplasm upon starvation) with BECN1; inhibits the interaction of BECN1 and BCL2 leading to promotion of autophagy. Interacts with KPNA1; involved in nuclear import. Interacts with SREBF1, TLR2, TLR4, TLR9, PTPRZ1, APEX1, FEN1, POLB, TERT. Interacts with IL1B, AGER, MSH2, XPA, XPC, HNF1A, TP53. Interacts with CD24; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response. Interacts with THBD; prevents HGMB1 interaction with ACER/RAGE and inhibits HGMB1 pro-inflammatory activity. Interacts with HAVCR2; impairs HMGB1 binding to B-DNA and likely HMGB1-mediated innate immune response. Interacts with XPO1; mediating nuclear export.|||Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance. Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins.|||Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. May be involved in nucleotide excision repair (NER), mismatch repair (MMR) and base excision repair (BER) pathways, and double strand break repair such as non-homologous end joining (NHEJ). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). In vitro can displace histone H1 from highly bent DNA. Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding. Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities. Facilitates binding of TP53 to DNA. May be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1. Can modulate the activity of the telomerase complex and may be involved in telomere maintenance.|||Nucleus|||Phosphorylated at serine residues. Phosphorylation in both NLS regions is required for cytoplasmic translocation followed by secretion.|||Poly-ADP-ribosylated by PARP1 when secreted following stimulation with LPS (By similarity).|||Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB1 (HMGB1C23hC45hC106h), 2- disulfide HMGB1 (HMGB1C23-C45C106h) and 3- sulfonyl HMGB1 (HMGB1C23soC45soC106so).|||Secreted|||The acidic C-terminal domain forms a flexible structure which can reversibly interact intramolecularily with the HMG boxes and modulate binding to DNA and other proteins. http://togogenome.org/gene/9541:LOC102146135 ^@ http://purl.uniprot.org/uniprot/A0A2K5V452 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystatin family.|||Secreted http://togogenome.org/gene/9541:PALS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||Endomembrane system|||tight junction http://togogenome.org/gene/9541:SYNDIG1L ^@ http://purl.uniprot.org/uniprot/A0A2K5WYG8 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:POLM ^@ http://purl.uniprot.org/uniprot/A0A2K5VJH6|||http://purl.uniprot.org/uniprot/A0A2K5VJL3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ).|||Nucleus http://togogenome.org/gene/9541:STAM ^@ http://purl.uniprot.org/uniprot/A0A2K5VRQ6|||http://purl.uniprot.org/uniprot/A0A7N9CM29|||http://purl.uniprot.org/uniprot/G7PEG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. http://togogenome.org/gene/9541:LOC101926697 ^@ http://purl.uniprot.org/uniprot/G7PQY3|||http://purl.uniprot.org/uniprot/P68223 ^@ Function|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the globin family.|||Heterotetramer of two alpha chains and two beta chains.|||Involved in oxygen transport from the lung to the various peripheral tissues.|||Red blood cells. http://togogenome.org/gene/9541:SGCG ^@ http://purl.uniprot.org/uniprot/A0A2K5W3M6|||http://purl.uniprot.org/uniprot/G8F3C1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9541:PIGL ^@ http://purl.uniprot.org/uniprot/A0A2K5UGL0 ^@ Function|||Similarity ^@ Belongs to the PIGL family.|||Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol. http://togogenome.org/gene/9541:LOC102143578 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKJ2|||http://purl.uniprot.org/uniprot/A0A8J8YDL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIP family.|||adherens junction|||centriolar satellite http://togogenome.org/gene/9541:SCN3B ^@ http://purl.uniprot.org/uniprot/G7PPD3|||http://purl.uniprot.org/uniprot/Q8HXJ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.|||Membrane|||Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity).|||Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.|||The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds (By similarity). http://togogenome.org/gene/9541:SHC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRP2|||http://purl.uniprot.org/uniprot/A0A2K5VRR9|||http://purl.uniprot.org/uniprot/A0A8J8Y8Q1|||http://purl.uniprot.org/uniprot/G7NUJ6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:ADAM22 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8N8|||http://purl.uniprot.org/uniprot/A0A2K5U8Q1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:TENT5C ^@ http://purl.uniprot.org/uniprot/A0A7N9D571|||http://purl.uniprot.org/uniprot/A0A8J8Y3K3|||http://purl.uniprot.org/uniprot/Q4R8X4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TENT family.|||Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression. Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein.|||Cytoplasm|||Interacts with BCCIP and PABPC1; the interaction has no effect on TENT5C poly(A) polymerase function. Interacts with PLK4; this interaction leads to the TENT5C recruitment into the centrosome.|||Nucleus|||centrosome http://togogenome.org/gene/9541:SEMA7A ^@ http://purl.uniprot.org/uniprot/A0A2K5TNJ4 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PRPS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWH5|||http://purl.uniprot.org/uniprot/Q4R4R7 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Activated by magnesium and inorganic phosphate.|||Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity).|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/9541:CYP2D8 ^@ http://purl.uniprot.org/uniprot/D8KWQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:RABAC1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y7H0|||http://purl.uniprot.org/uniprot/G7PXQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/9541:ALPL ^@ http://purl.uniprot.org/uniprot/A0A2K5U1L9|||http://purl.uniprot.org/uniprot/G7NUV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline phosphatase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TM9SF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W768 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9541:ASB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VY87 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:UBE2H ^@ http://purl.uniprot.org/uniprot/A0A7N9D7E5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:FNBP1L ^@ http://purl.uniprot.org/uniprot/A0A2K5UFN8|||http://purl.uniprot.org/uniprot/A0A2K5UFT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNBP1 family.|||Cell membrane|||Cytoplasmic vesicle|||Membrane|||Vesicle|||cell cortex|||cytoskeleton http://togogenome.org/gene/9541:MAPK7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VW59|||http://purl.uniprot.org/uniprot/A0A2K5VW63 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9541:PLSCR1 ^@ http://purl.uniprot.org/uniprot/I7GJ06 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9541:SERPINF1 ^@ http://purl.uniprot.org/uniprot/I7GPF3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:CYP39A1 ^@ http://purl.uniprot.org/uniprot/Q2PFP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:SEMA6A ^@ http://purl.uniprot.org/uniprot/A0A2K5WVN5|||http://purl.uniprot.org/uniprot/A0A2K5WVQ5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC102127544 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TPST2 ^@ http://purl.uniprot.org/uniprot/G7PHG0|||http://purl.uniprot.org/uniprot/Q4R863 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein sulfotransferase family.|||Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.|||Golgi apparatus membrane|||Homodimer. Can also form heterodimers with TPST1.|||N-glycosylated.|||Substrate peptides must be flexible in order to adopt an L-shaped conformation in the deep binding cleft. http://togogenome.org/gene/9541:LOC102119500 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PIF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the helicase family. PIF1 subfamily.|||DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.|||Mitochondrion|||Monomer. Interacts with telomerase.|||Nucleus http://togogenome.org/gene/9541:SOX10 ^@ http://purl.uniprot.org/uniprot/A0A2K5USS4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LAPTM5 ^@ http://purl.uniprot.org/uniprot/I7G9Q1 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9541:XKR7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9541:LOC101925699 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQS6|||http://purl.uniprot.org/uniprot/G7PH36|||http://purl.uniprot.org/uniprot/I7GE22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYBC1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:SEMA3A ^@ http://purl.uniprot.org/uniprot/A0A2K5VGJ0 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:MINAR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WM24 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/9541:RPS10 ^@ http://purl.uniprot.org/uniprot/I7G299 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/9541:BCLAF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8S2|||http://purl.uniprot.org/uniprot/A0A8J8XDS4|||http://purl.uniprot.org/uniprot/G7Q2C2 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/9541:KIF27 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVX3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:ELAVL4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYQ9|||http://purl.uniprot.org/uniprot/A0A2K5WYZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm|||Perikaryon|||axon|||dendrite|||growth cone http://togogenome.org/gene/9541:RPL29 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPR9|||http://purl.uniprot.org/uniprot/A0A2K5UQ90 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL29 family. http://togogenome.org/gene/9541:ACTR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKV4|||http://purl.uniprot.org/uniprot/A0A2K5VKX2|||http://purl.uniprot.org/uniprot/A0A2K5VL34 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:SNRNP200 ^@ http://purl.uniprot.org/uniprot/A0A2K5X457 ^@ Similarity ^@ Belongs to the helicase family. SKI2 subfamily. http://togogenome.org/gene/9541:TAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVJ0 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. http://togogenome.org/gene/9541:TACC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||centrosome http://togogenome.org/gene/9541:IGF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VND9|||http://purl.uniprot.org/uniprot/A0A2K5VNE3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.|||Secreted http://togogenome.org/gene/9541:ZC3HC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPS7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:XPNPEP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y9Q8|||http://purl.uniprot.org/uniprot/G7Q3N2 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/9541:TMEM70 ^@ http://purl.uniprot.org/uniprot/A0A7N9CGT8 ^@ Similarity ^@ Belongs to the TMEM70 family. http://togogenome.org/gene/9541:QARS1 ^@ http://purl.uniprot.org/uniprot/Q4R5D7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:UNC13B ^@ http://purl.uniprot.org/uniprot/A0A2K5W9X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-13 family.|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:PMEL ^@ http://purl.uniprot.org/uniprot/Q4R7T2 ^@ Similarity ^@ Belongs to the PMEL/NMB family. http://togogenome.org/gene/9541:CEP57 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBP1|||http://purl.uniprot.org/uniprot/A0A2K5WBP5|||http://purl.uniprot.org/uniprot/G7PNI4|||http://purl.uniprot.org/uniprot/Q4R704 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/9541:PIGB ^@ http://purl.uniprot.org/uniprot/A0A2K5WDT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.|||Membrane http://togogenome.org/gene/9541:IVD ^@ http://purl.uniprot.org/uniprot/G8F3Q0 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9541:LOC102144039 ^@ http://purl.uniprot.org/uniprot/A0A8J8XSB1|||http://purl.uniprot.org/uniprot/A4L283 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9541:FCGR3A ^@ http://purl.uniprot.org/uniprot/Q8SPW2 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Cell membrane|||Forms a heterooligomeric complex with ITAM-containing signaling subunits, either a homodimer of CD247, a homodimer of FCER1G or a heterodimer of CD247 and FCER1G. Interacts (via transmembrane domain) with signaling subunits; this interaction is a prerequisite for receptor complex expression on the cell surface and intracellular signal transduction. Binds the Fc region of antigen-complexed IgG with a preference for IgG1 and IgG3 isotypes (By similarity). Interacts with CD2; this interaction is involved in NK cell activation and cytotoxicity (By similarity). Interacts with S100A4; this interaction inhibits PKC-dependent phosphorylation of FCGR3A (By similarity).|||Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG1 and IgG2.|||Lymphocytes and monocytes.|||Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (By similarity). Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation. Involved in the generation of memory-like adaptive NK cells capable to produce high amounts of IFNG and to efficiently eliminate virus-infected cells via ADCC. Regulates NK cell survival and proliferation, in particular by preventing NK cell progenitor apoptosis (By similarity). Fc-binding subunit that associates with CD247 and/or FCER1G adapters to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation. The ITAM-dependent signaling coupled to receptor phosphorylation by PKC mediates robust intracellular calcium flux that leads to production of pro-inflammatory cytokines, whereas in the absence of receptor phosphorylation it mainly activates phosphatidylinositol 3-kinase signaling leading to cell degranulation (By similarity). Costimulates NK cells and trigger lysis of target cells independently of IgG binding (By similarity). Mediates the antitumor activities of therapeutic antibodies. Upon ligation on monocytes triggers TNFA-dependent ADCC of IgG-coated tumor cells (By similarity). Mediates enhanced ADCC in response to afucosylated IgGs (By similarity).|||Secreted|||Undergoes rapid ectodomain shedding upon NK cell stimulation. The soluble form is produced by a proteolytic cleavage mediated by ADAM17. Repeated stimulation causes receptor shedding, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells while avoiding activation-induced NK cell apoptosis. http://togogenome.org/gene/9541:MAS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane http://togogenome.org/gene/9541:KCNK18 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9541:LOC102119092 ^@ http://purl.uniprot.org/uniprot/G7P2N0|||http://purl.uniprot.org/uniprot/Q4R362 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.|||Belongs to the histone H4 family.|||Butyrylation of histones marks active promoters and competes with histone acetylation.|||Chromosome|||Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).|||Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.|||Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.|||Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.|||Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).|||Nucleus|||Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).|||Sumoylated, which is associated with transcriptional repression.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).|||Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. http://togogenome.org/gene/9541:RBP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XRQ6|||http://purl.uniprot.org/uniprot/G7P027 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:DKK3 ^@ http://purl.uniprot.org/uniprot/Q4R4I7 ^@ Similarity ^@ Belongs to the dickkopf family. http://togogenome.org/gene/9541:XKR9 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9541:IPPK ^@ http://purl.uniprot.org/uniprot/A0A2K5WBK7 ^@ Domain|||Function|||Similarity ^@ Belongs to the IPK1 type 2 family.|||Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).|||The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2. http://togogenome.org/gene/9541:MEP1A ^@ http://purl.uniprot.org/uniprot/A0A2K5TPQ3|||http://purl.uniprot.org/uniprot/G7P4S4 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:LTF ^@ http://purl.uniprot.org/uniprot/A0A2K5WLE6 ^@ Similarity ^@ Belongs to the transferrin family. http://togogenome.org/gene/9541:SCN1B ^@ http://purl.uniprot.org/uniprot/A0A2K5V251|||http://purl.uniprot.org/uniprot/A0A2K5V2A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.|||Cell membrane|||Membrane|||Perikaryon|||axon http://togogenome.org/gene/9541:SLC22A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5L2 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/9541:EDA ^@ http://purl.uniprot.org/uniprot/A0A2K5VYD5 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9541:LDB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULE9|||http://purl.uniprot.org/uniprot/A0A2K5ULR2 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/9541:ASB9 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5D5 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:THAP5 ^@ http://purl.uniprot.org/uniprot/Q4R7M0 ^@ Caution|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cleaved by HTRA2 during apoptosis.|||Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase.|||Interacts with HTRA2; under apoptotic conditions. Interacts with ABRAXAS2.|||It is uncertain whether Met-1 or Met-2 is the initiator.|||Nucleus http://togogenome.org/gene/9541:CCL23 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBA5|||http://purl.uniprot.org/uniprot/G7PU52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:SLC35A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WST2|||http://purl.uniprot.org/uniprot/A0A2K5WSV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Membrane http://togogenome.org/gene/9541:HCK ^@ http://purl.uniprot.org/uniprot/Q95M30 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.|||Cell membrane|||Cytoplasmic vesicle|||Golgi apparatus|||Interacts with ADAM15. Interacts with FASLG. Interacts with ARRB1 and ARRB2. Interacts with FCGR1A; the interaction may be indirect. Interacts with IL6ST. Interacts (via SH3 domain) with ELMO1. Interacts (via SH3 domain) with TP73. Interacts with YAP1. Interacts with ABL1 and ITGB1, and thereby recruits ABL1 to activated ITGB1. Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with CBL. Interacts with VAV1, WAS and RAPGEF1. Interacts (via SH3 domain) with WDCP.|||Lysosome|||Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS (By similarity).|||Nucleus|||Palmitoylation requires prior myristoylation. Palmitoylation is required for caveolar localization (By similarity).|||Phosphorylated on several tyrosine residues. Autophosphorylated. Becomes rapidly phosphorylated upon activation of the immunoglobulin receptors FCGR1A and FCGR2A. Phosphorylation at Tyr-389 increases kinase activity. Phosphorylation at Tyr-500 inhibits kinase activity. Kinase activity is not required for phosphorylation at Tyr-500, suggesting that this site may be a target of other kinases (By similarity).|||Subject to autoinhibition, mediated by intramolecular interactions involving the SH2 and SH3 domains. Kinase activity is also regulated by phosphorylation at regulatory tyrosine residues. Phosphorylation at Tyr-389 is required for optimal activity. Phosphorylation at Tyr-500 inhibits kinase activity (By similarity).|||Ubiquitinated by CBL, leading to its degradation via the proteasome.|||caveola|||cytoskeleton|||cytosol|||focal adhesion|||secretory vesicle http://togogenome.org/gene/9541:LOC101925320 ^@ http://purl.uniprot.org/uniprot/Q4R8D3 ^@ Similarity ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. http://togogenome.org/gene/9541:TSPAN11 ^@ http://purl.uniprot.org/uniprot/A0A7N9D223 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:POLR2H ^@ http://purl.uniprot.org/uniprot/G7NYZ5 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/9541:SHBG ^@ http://purl.uniprot.org/uniprot/A0A2K5X8C8|||http://purl.uniprot.org/uniprot/A0A2K5X8X0|||http://purl.uniprot.org/uniprot/G7PTI7|||http://purl.uniprot.org/uniprot/Q4R6W8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC102132017 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEN0 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Membrane|||Mitochondrion inner membrane|||The Rieske protein is a high potential 2Fe-2S protein. http://togogenome.org/gene/9541:LOC102137780 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHL8|||http://purl.uniprot.org/uniprot/G7PNJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:CCL11 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:IPO8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFC7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:CCDC124 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNQ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CCDC124 family.|||Interacts with RASGEF1B.|||Required for proper progression of late cytokinetic stages. http://togogenome.org/gene/9541:SEPTIN11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXY1|||http://purl.uniprot.org/uniprot/A0A2K5VXY3|||http://purl.uniprot.org/uniprot/A0A2K5VY70|||http://purl.uniprot.org/uniprot/A0A7N9D789|||http://purl.uniprot.org/uniprot/Q4R555 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity).|||Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules (By similarity). Forms homooligomers (By similarity). GTPase activity is required for filament formation (By similarity). Interacts with SEPTIN7, SEPTIN9 and SEPTIN12 (By similarity).|||Septins polymerize into heterooligomeric protein complexes that form filaments.|||Synapse|||axon|||cytoskeleton|||dendritic spine http://togogenome.org/gene/9541:SFRP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WND6|||http://purl.uniprot.org/uniprot/G8F2Z7 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:CTNNBL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1L3|||http://purl.uniprot.org/uniprot/G7PGF2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PEX26 ^@ http://purl.uniprot.org/uniprot/Q9BE65 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxin-26 family.|||Interacts (via its cytoplasmic domain) with PEX6; interaction is direct and is ATP-dependent. Interacts with PEX1; interaction is indirect and is mediated via interaction with PEX6.|||Peroxisomal docking factor that anchors PEX1 and PEX6 to peroxisome membranes. PEX26 is therefore required for the formation of the PEX1-PEX6 AAA ATPase complex, a complex that mediates the extraction of the PEX5 receptor from peroxisomal membrane.|||Peroxisome membrane http://togogenome.org/gene/9541:IRAK1BP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V741 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRAK1BP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:GPC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VK50 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan that bears heparan sulfate. http://togogenome.org/gene/9541:MYO5A ^@ http://purl.uniprot.org/uniprot/A0A2K5W139|||http://purl.uniprot.org/uniprot/A0A2K5W143|||http://purl.uniprot.org/uniprot/A0A2K5W1G4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:POSTN ^@ http://purl.uniprot.org/uniprot/A0A2K5VW02|||http://purl.uniprot.org/uniprot/A0A2K5VW23|||http://purl.uniprot.org/uniprot/A0A2K5VW96|||http://purl.uniprot.org/uniprot/A0A2K5VWG9|||http://purl.uniprot.org/uniprot/G7PW19 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9541:ADCY6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPL3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9541:PAXBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6G2|||http://purl.uniprot.org/uniprot/A0A2K5W6I8 ^@ Similarity ^@ Belongs to the GCF family. http://togogenome.org/gene/9541:RARA ^@ http://purl.uniprot.org/uniprot/A0A2K5V0N0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:MAPK14 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJV8|||http://purl.uniprot.org/uniprot/A0A2K5WJW8|||http://purl.uniprot.org/uniprot/A0A8J8Y992 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9541:LDHC ^@ http://purl.uniprot.org/uniprot/A0A2K5WD20|||http://purl.uniprot.org/uniprot/Q4R6K1 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9541:NKAIN3 ^@ http://purl.uniprot.org/uniprot/I7GNL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:VAT1L ^@ http://purl.uniprot.org/uniprot/A0A8J8YT23|||http://purl.uniprot.org/uniprot/G7Q1P8 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9541:LOC102143300 ^@ http://purl.uniprot.org/uniprot/A0A2K5VH37 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 37 family. http://togogenome.org/gene/9541:MTERF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMK4 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9541:IFNA8 ^@ http://purl.uniprot.org/uniprot/G7PS89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9541:AKAP8 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0C4 ^@ Similarity ^@ Belongs to the AKAP95 family. http://togogenome.org/gene/9541:LOC102129291 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y8V5|||http://purl.uniprot.org/uniprot/A7XEI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hepcidin family.|||Secreted http://togogenome.org/gene/9541:TMTC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9541:TMEM234 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPQ7|||http://purl.uniprot.org/uniprot/A0A2K5VPR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM234 family.|||Membrane http://togogenome.org/gene/9541:EGFL7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VD40 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:EGFL8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHB9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:BLOC1S1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BLOC1S1 family.|||Lysosome membrane|||May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.|||Mitochondrion intermembrane space http://togogenome.org/gene/9541:CALB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VV88|||http://purl.uniprot.org/uniprot/G7Q1K6 ^@ Function|||Similarity ^@ Belongs to the calbindin family.|||Calretinin is a calcium-binding protein which is abundant in auditory neurons. http://togogenome.org/gene/9541:ACKR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UF52 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Early endosome|||Endosome|||Membrane|||Monomer. Can form homodimers. Interacts with CD164. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARR3; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts with RNF113A; the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and subsequent degradation. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with DBN1; this interaction is enhanced by antigenic stimulation. Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8.|||Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. http://togogenome.org/gene/9541:LOC102145339 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPJ1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:THOC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7V1|||http://purl.uniprot.org/uniprot/A0A2K5U7V6|||http://purl.uniprot.org/uniprot/G7PHI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC5 family.|||Nucleus http://togogenome.org/gene/9541:XCR1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJL1|||http://purl.uniprot.org/uniprot/G7NY37 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:KCNJ11 ^@ http://purl.uniprot.org/uniprot/A0A8J8YNU2|||http://purl.uniprot.org/uniprot/G7PQM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.|||Membrane http://togogenome.org/gene/9541:HSPD1 ^@ http://purl.uniprot.org/uniprot/I7G496 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/9541:LOC102126820 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7K6|||http://purl.uniprot.org/uniprot/G7PTU1 ^@ Similarity ^@ Belongs to the GRB2/sem-5/DRK family. http://togogenome.org/gene/9541:AGAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7K4 ^@ Similarity ^@ Belongs to the centaurin gamma-like family. http://togogenome.org/gene/9541:PITPNM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDU9 ^@ Similarity ^@ Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. http://togogenome.org/gene/9541:ARPC1A ^@ http://purl.uniprot.org/uniprot/I7GK84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||Nucleus|||cytoskeleton http://togogenome.org/gene/9541:PNMA2 ^@ http://purl.uniprot.org/uniprot/G7PCY0|||http://purl.uniprot.org/uniprot/Q9GMU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PNMA family.|||nucleolus http://togogenome.org/gene/9541:SNCA ^@ http://purl.uniprot.org/uniprot/G7P5X2|||http://purl.uniprot.org/uniprot/P61142 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.|||Belongs to the synuclein family.|||Cytoplasm|||Membrane|||Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (By similarity). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity).|||Nucleus|||Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress.|||Secreted|||Soluble monomer. Homotetramer. A dynamic intracellular population of tetramers and monomers coexists normally and the tetramer plays an essential role in maintaining homeostasis (By similarity). Interacts with UCHL1 (By similarity). Interacts with phospholipase D and histones. Interacts (via N-terminus) with synphilin-1/SNCAIP; this interaction promotes formation of SNCA inclusions in the cytoplasm. Interacts with CALM1. Interacts with STXBP1; this interaction controls SNCA self-replicating aggregation. Interacts with SNARE components VAMP2 and SNAP25; these interactions allows SNARE complex assembly and integrity (By similarity). Interacts with RPH3A and RAB3A (By similarity). Interacts with SERF1A; this interaction promotes the aggregation of SNCA (By similarity). Interacts with SEPTIN4 (By similarity).|||Synapse|||Ubiquitinated. The predominant conjugate is the diubiquitinated form.|||axon http://togogenome.org/gene/9541:ZNF75D ^@ http://purl.uniprot.org/uniprot/A0A2K5X9F7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:AQP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.|||Membrane http://togogenome.org/gene/9541:CFHR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEE7|||http://purl.uniprot.org/uniprot/G8F5N7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:FTH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDS4|||http://purl.uniprot.org/uniprot/I7GH92 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9541:DDX52 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8Z0 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily. http://togogenome.org/gene/9541:POP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQZ8|||http://purl.uniprot.org/uniprot/G7PJ50 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/9541:DYNC2LI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light intermediate chain family.|||centrosome|||cilium|||cilium axoneme|||cilium basal body http://togogenome.org/gene/9541:MMUT ^@ http://purl.uniprot.org/uniprot/Q8HXX1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methylmalonyl-CoA mutase family.|||Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.|||Cytoplasm|||Homodimer. Interacts (the apoenzyme form) with MMAA; the interaction is GTP dependent.|||Inhibited by itaconyl-CoA, a metabolite that inactivates the coenzyme B12 cofactor.|||Mitochondrion|||Mitochondrion matrix http://togogenome.org/gene/9541:GLYATL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAQ4 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/9541:CBR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UW11|||http://purl.uniprot.org/uniprot/G7P114 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9541:IMPG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7R1|||http://purl.uniprot.org/uniprot/A0A2K5V7T1 ^@ Subcellular Location Annotation ^@ interphotoreceptor matrix http://togogenome.org/gene/9541:DEFB123 ^@ http://purl.uniprot.org/uniprot/A0A8J8XK90|||http://purl.uniprot.org/uniprot/G7PGP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:IK ^@ http://purl.uniprot.org/uniprot/I7G2E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RED family.|||Nucleus http://togogenome.org/gene/9541:SNX11 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAR5|||http://purl.uniprot.org/uniprot/G7PU67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/9541:SELENBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8R1|||http://purl.uniprot.org/uniprot/I7GK56 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the selenium-binding protein family.|||Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.|||Interacts with USP33.|||Membrane|||Nucleus|||cytosol http://togogenome.org/gene/9541:ODC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKX8 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9541:CELF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VD81|||http://purl.uniprot.org/uniprot/A0A2K5VD83|||http://purl.uniprot.org/uniprot/Q4R535 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus|||RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity). http://togogenome.org/gene/9541:LOC102117971 ^@ http://purl.uniprot.org/uniprot/A0A2K5UG48 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:ABCB11 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2H2 ^@ Subcellular Location Annotation ^@ Endosome http://togogenome.org/gene/9541:HARS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U175|||http://purl.uniprot.org/uniprot/A0A2K5U1A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/9541:ATG12 ^@ http://purl.uniprot.org/uniprot/I7GIF3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATG12 family.|||Forms a conjugate with ATG5.|||Ubiquitin-like protein involved in autophagic vesicle formation. http://togogenome.org/gene/9541:KCNE1 ^@ http://purl.uniprot.org/uniprot/C7S322 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9541:SPC25 ^@ http://purl.uniprot.org/uniprot/A0A8J8YF95|||http://purl.uniprot.org/uniprot/G7PKR2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC25 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9541:REV3L ^@ http://purl.uniprot.org/uniprot/A0A2K5TLA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||Nucleus http://togogenome.org/gene/9541:SLCO3A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WG09 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PATJ ^@ http://purl.uniprot.org/uniprot/A0A2K5V353 ^@ Subcellular Location Annotation ^@ tight junction http://togogenome.org/gene/9541:CRYBB3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YC17|||http://purl.uniprot.org/uniprot/G7PHE6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/9541:DGAT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCM0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Homodimer or homotetramer; both forms have similar enzymatic activities.|||Membrane http://togogenome.org/gene/9541:CDK5RAP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTQ7 ^@ Similarity ^@ Belongs to the CDK5RAP3 family. http://togogenome.org/gene/9541:COQ8B ^@ http://purl.uniprot.org/uniprot/A0A2K5WMA1|||http://purl.uniprot.org/uniprot/G7PXM3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/9541:RDH10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVZ5|||http://purl.uniprot.org/uniprot/A0A2K5UW13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9541:DHX29 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.|||Belongs to the DEAD box helicase family. DEAH subfamily.|||Cytoplasm|||Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit. http://togogenome.org/gene/9541:PLIN5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6B3 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9541:PSMD5 ^@ http://purl.uniprot.org/uniprot/Q5IFJ8 ^@ Domain|||Function|||Similarity|||Subunit ^@ Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5 (By similarity).|||Belongs to the proteasome subunit S5B/HSM3 family.|||Interacts with PSMC1, PSMC2, PSMD1 and PSMD6. Part of transient complex containing PSMD5, PSMC2, PSMC1 and PSMD2 formed during the assembly of the 26S proteasome (By similarity).|||Rich in dileucine repeats, which have been implicated in trafficking of a variety of transmembrane proteins. http://togogenome.org/gene/9541:MZT2B ^@ http://purl.uniprot.org/uniprot/A0A2K5WDI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MOZART2 family.|||centrosome|||spindle http://togogenome.org/gene/9541:NTSR2 ^@ http://purl.uniprot.org/uniprot/Q2PFN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ANAPC16 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5W4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC16 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||Cytoplasm|||Nucleus|||kinetochore http://togogenome.org/gene/9541:NAA40 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6T7|||http://purl.uniprot.org/uniprot/A0A7N9CM48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA40 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:RPS8 ^@ http://purl.uniprot.org/uniprot/G7P6T4|||http://purl.uniprot.org/uniprot/Q4R6P8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Cytoplasm|||Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.|||Membrane http://togogenome.org/gene/9541:IRF7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXS9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:AICDA ^@ http://purl.uniprot.org/uniprot/A0A2K5WJH5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:MGMT ^@ http://purl.uniprot.org/uniprot/G7PEI1 ^@ Function|||Similarity ^@ Belongs to the MGMT family.|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. http://togogenome.org/gene/9541:LOC102121175 ^@ http://purl.uniprot.org/uniprot/A0A2K5UV29 ^@ Subcellular Location Annotation ^@ Nucleus|||kinetochore http://togogenome.org/gene/9541:NSDHL ^@ http://purl.uniprot.org/uniprot/A0A2K5UDV0|||http://purl.uniprot.org/uniprot/G7Q1Y4 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9541:RBFOX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZD0|||http://purl.uniprot.org/uniprot/A0A2K5UZE0|||http://purl.uniprot.org/uniprot/A0A2K5UZG0 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||RNA-binding protein that regulates alternative splicing events. http://togogenome.org/gene/9541:CHRNA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WB27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:KCNK6 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9541:MED7 ^@ http://purl.uniprot.org/uniprot/A0A8J8YMB4|||http://purl.uniprot.org/uniprot/G7P6Q8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9541:FAM20C ^@ http://purl.uniprot.org/uniprot/A0A2K5VCN7 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/9541:SCRN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDH9 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/9541:MRPL58 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIS6 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9541:LOC102121500 ^@ http://purl.uniprot.org/uniprot/G7P2L9|||http://purl.uniprot.org/uniprot/G7P2N0|||http://purl.uniprot.org/uniprot/Q4R362 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.|||Belongs to the histone H4 family.|||Butyrylation of histones marks active promoters and competes with histone acetylation.|||Chromosome|||Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).|||Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.|||Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.|||Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.|||Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).|||Nucleus|||Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).|||Sumoylated, which is associated with transcriptional repression.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).|||Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. http://togogenome.org/gene/9541:IL5RA ^@ http://purl.uniprot.org/uniprot/C3VEW9 ^@ Similarity ^@ Belongs to the type I cytokine receptor family. Type 5 subfamily. http://togogenome.org/gene/9541:HOXC11 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9541:XRCC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0B0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TBCE ^@ http://purl.uniprot.org/uniprot/A0A2K5WD55|||http://purl.uniprot.org/uniprot/A0A2K5WD80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCE family.|||Belongs to the eukaryotic ribosomal protein eS21 family.|||Cytoplasm http://togogenome.org/gene/9541:PRPF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3L9 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9541:HOXB13 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY17|||http://purl.uniprot.org/uniprot/G7PU80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9541:LOC102135243 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULA2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/9541:CYP1A2 ^@ http://purl.uniprot.org/uniprot/O77809 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer. Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. Metabolizes caffeine via N3-demethylation.|||Belongs to the cytochrome P450 family.|||By 3-methylcholanthrene (3MC).|||Endoplasmic reticulum membrane|||Interacts with PGRMC1; the interaction requires PGRMC1 homodimerization.|||Liver.|||Microsome membrane http://togogenome.org/gene/9541:BMPR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0S9|||http://purl.uniprot.org/uniprot/A0A2K5V0T2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. http://togogenome.org/gene/9541:TCL1B ^@ http://purl.uniprot.org/uniprot/G7PBF1 ^@ Similarity ^@ Belongs to the TCL1 family. http://togogenome.org/gene/9541:MRPL54 ^@ http://purl.uniprot.org/uniprot/A0A2K5W963 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL54 family.|||Mitochondrion http://togogenome.org/gene/9541:RBPMS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VT66 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:RGS2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2I1|||http://purl.uniprot.org/uniprot/G7NXE1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||Membrane|||nucleolus http://togogenome.org/gene/9541:EIF2B2 ^@ http://purl.uniprot.org/uniprot/I7GK81 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/9541:UBE2A ^@ http://purl.uniprot.org/uniprot/A0A2K5X700 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:AP3D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V773 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adaptor protein complex 3 (AP-3) is a heterotetramer.|||Belongs to the adaptor complexes large subunit family.|||Golgi apparatus|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. http://togogenome.org/gene/9541:WNT7A ^@ http://purl.uniprot.org/uniprot/G7NYG1|||http://purl.uniprot.org/uniprot/Q1KYK9 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Wnt family.|||Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids (By similarity). Interacts with FZD5. Interacts with PORCN (By similarity). Interacts (via intrinsically disordered linker region) with RECK; interaction with RECK confers ligand selectivity for Wnt7 in brain endothelial cells and allows these cells to selectively respond to Wnt7 (By similarity).|||Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal neural stem cell proliferation in the hippocampus dentate gyrus. Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation. Promotes formation of synapses via its interaction with FZD5 (By similarity).|||Ligand for members of the frizzled family of seven transmembrane receptors.|||Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.|||Secreted|||The intrinsically disordered linker region is required for recognition by RECK in brain endothelial cells.|||extracellular matrix http://togogenome.org/gene/9541:IFT122 ^@ http://purl.uniprot.org/uniprot/A0A2K5URI3|||http://purl.uniprot.org/uniprot/A0A2K5URK0 ^@ Subcellular Location Annotation ^@ cilium http://togogenome.org/gene/9541:PBX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYY0|||http://purl.uniprot.org/uniprot/A0A2K5TYY4|||http://purl.uniprot.org/uniprot/A0A2K5TYZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/9541:CPZ ^@ http://purl.uniprot.org/uniprot/A0A2K5WQF9 ^@ Caution|||Similarity ^@ Belongs to the peptidase M14 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:TSFM ^@ http://purl.uniprot.org/uniprot/A0A2K5U4N6|||http://purl.uniprot.org/uniprot/A0A2K5U4Q8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Mitochondrion http://togogenome.org/gene/9541:PGLYRP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ61 ^@ Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. http://togogenome.org/gene/9541:TTC29 ^@ http://purl.uniprot.org/uniprot/Q4R6M4 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Axonemal protein which is implicated in axonemal and/or peri-axonemal structures assembly and regulates flagella assembly and beating and therefore sperm motility.|||The TPR repeats are required for proper localization into the axoneme and proper function in flagella beating and motility.|||flagellum axoneme http://togogenome.org/gene/9541:GPX5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDB5|||http://purl.uniprot.org/uniprot/G7P3T2|||http://purl.uniprot.org/uniprot/P28714 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the glutathione peroxidase family.|||Epididymis.|||Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.|||Secreted http://togogenome.org/gene/9541:CLCNKB ^@ http://purl.uniprot.org/uniprot/A0A2K5V6E5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:HYI ^@ http://purl.uniprot.org/uniprot/A0A2K5VFE9|||http://purl.uniprot.org/uniprot/A0A2K5VFF2 ^@ Function|||Similarity ^@ Belongs to the hyi family.|||Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). http://togogenome.org/gene/9541:KRT222 ^@ http://purl.uniprot.org/uniprot/A0A8J8YLD5|||http://purl.uniprot.org/uniprot/G7PUP3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:MMP14 ^@ http://purl.uniprot.org/uniprot/A0A8J8XW92|||http://purl.uniprot.org/uniprot/G7P9U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Cytoplasm|||Melanosome http://togogenome.org/gene/9541:CCHCR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSC6 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be a regulator of keratinocyte proliferation or differentiation.|||Nucleus http://togogenome.org/gene/9541:LSM6 ^@ http://purl.uniprot.org/uniprot/A0A2K5V611|||http://purl.uniprot.org/uniprot/G8F3L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/9541:PAH ^@ http://purl.uniprot.org/uniprot/A0A2K5W2M4|||http://purl.uniprot.org/uniprot/G7PJC2 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9541:DDX49 ^@ http://purl.uniprot.org/uniprot/A0A2K5VP37|||http://purl.uniprot.org/uniprot/G7PX05 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9541:LRP2BP ^@ http://purl.uniprot.org/uniprot/Q4R3N2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with LRP2.|||May act as an adapter that regulates LRP2 function. http://togogenome.org/gene/9541:PHGDH ^@ http://purl.uniprot.org/uniprot/A0A158SIP3|||http://purl.uniprot.org/uniprot/Q60HD7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.|||Homotetramer. http://togogenome.org/gene/9541:KCNS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQH5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:FSHB ^@ http://purl.uniprot.org/uniprot/G7PQH7|||http://purl.uniprot.org/uniprot/Q6EV79 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer. The active follitropin is a heterodimer composed of an alpha chain/CGA shared with other hormones and a unique beta chain/FSHB shown here.|||Secreted|||Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:10612425). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (By similarity). http://togogenome.org/gene/9541:RPN1 ^@ http://purl.uniprot.org/uniprot/Q4R4T0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST1 family.|||Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity). Interacts with TMEM35A/NACHO (By similarity).|||Endoplasmic reticulum|||Endoplasmic reticulum membrane|||Melanosome|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.|||Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets. http://togogenome.org/gene/9541:UBL4A ^@ http://purl.uniprot.org/uniprot/A0A7N9CJ55 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/9541:CLDN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJH5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:SNRPA1 ^@ http://purl.uniprot.org/uniprot/G7P9K0|||http://purl.uniprot.org/uniprot/Q4R8Y8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U2 small nuclear ribonucleoprotein A family.|||Identified in the spliceosome B complex. Identified in the spliceosome C complex. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B. Contributes to the binding of stem loop IV of U2 snRNA with SNRPB2.|||Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA.|||Nucleus http://togogenome.org/gene/9541:MARK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4F5|||http://purl.uniprot.org/uniprot/A0A2K5V4G4|||http://purl.uniprot.org/uniprot/A0A2K5V4J1|||http://purl.uniprot.org/uniprot/A0A2K5V4L6|||http://purl.uniprot.org/uniprot/A0A7N9DD34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9541:RBM47 ^@ http://purl.uniprot.org/uniprot/A0A2K5WK38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM RBM47 family.|||Nucleus http://togogenome.org/gene/9541:HEATR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VP80 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HEATR1/UTP10 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/9541:HCRTR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LAMTOR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.|||Belongs to the LAMTOR3 family.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/9541:PTPRM ^@ http://purl.uniprot.org/uniprot/A0A2K5U181|||http://purl.uniprot.org/uniprot/A0A2K5U1C1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.|||Membrane http://togogenome.org/gene/9541:CMC2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XBQ7|||http://purl.uniprot.org/uniprot/G7PZT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/9541:PNPLA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U414 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:METTL16 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNT6|||http://purl.uniprot.org/uniprot/Q4R9F9 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METTL16/RlmF family.|||RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. http://togogenome.org/gene/9541:ARSJ ^@ http://purl.uniprot.org/uniprot/A0A2K5UI24 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9541:ZFP69B ^@ http://purl.uniprot.org/uniprot/A0A2K5VHX0|||http://purl.uniprot.org/uniprot/G7NUD5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NXF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTK3|||http://purl.uniprot.org/uniprot/A0A2K5VTR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NXF family.|||Cytoplasm|||nucleoplasm http://togogenome.org/gene/9541:ACTR10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||cytoskeleton http://togogenome.org/gene/9541:SLC15A5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7S5|||http://purl.uniprot.org/uniprot/G7PJY9 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. http://togogenome.org/gene/9541:RAD21 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/9541:CBX2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CZ26 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SLC6A8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZP2 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:BEST1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6P4|||http://purl.uniprot.org/uniprot/Q6UY87 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Basolateral cell membrane|||Belongs to the bestrophin family.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate (By similarity).|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane|||Phosphorylated by PP2A.|||Tetramer or pentamers. May interact with PPP2CB and PPP2R1B (By similarity). http://togogenome.org/gene/9541:YME1L1 ^@ http://purl.uniprot.org/uniprot/Q4R4Z4 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/9541:TMC8 ^@ http://purl.uniprot.org/uniprot/A0A2K5X732 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/9541:LOC102118666 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVT5 ^@ Similarity ^@ Belongs to the FAM25 family. http://togogenome.org/gene/9541:TNS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1T3 ^@ Subcellular Location Annotation ^@ focal adhesion http://togogenome.org/gene/9541:LOC102117998 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:KIF18A ^@ http://purl.uniprot.org/uniprot/A0A2K5TYW8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:TOX4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQH0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FAM220A ^@ http://purl.uniprot.org/uniprot/Q4R3X9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with STAT3.|||May negatively regulate STAT3.|||Nucleus http://togogenome.org/gene/9541:KIF19 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCS6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:XPA ^@ http://purl.uniprot.org/uniprot/A0A2K5TWB0|||http://purl.uniprot.org/uniprot/G7PRW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPA family.|||Nucleus http://togogenome.org/gene/9541:MVB12B ^@ http://purl.uniprot.org/uniprot/A0A2K5WF98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MVB12 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9541:CYP7B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:GREM1 ^@ http://purl.uniprot.org/uniprot/A0A7N9DCE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/9541:RTN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPJ0|||http://purl.uniprot.org/uniprot/A0A2K5UPK0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:DCAF12 ^@ http://purl.uniprot.org/uniprot/Q4R3J7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat DCAF12 family.|||Component of the DCX(DCAF12) E3 ubiquitin ligase complex, at least composed of CUL4 (CUL4A or CUL4B), DDB1, DCAF12 and RBX1.|||Cytoplasm|||Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus, such as MAGEA3, MAGEA6 and CCT5, leading to their ubiquitination and degradation. Ubiquitination of MAGEA3, MAGEA6 by DCX(DCAF12) complex is required for starvation-induced autophagy.|||centrosome http://togogenome.org/gene/9541:RAB3GAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UK30|||http://purl.uniprot.org/uniprot/A0A2K5UK56|||http://purl.uniprot.org/uniprot/A0A2K5UK95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab3-GAP catalytic subunit family.|||Cytoplasm http://togogenome.org/gene/9541:FAM174B ^@ http://purl.uniprot.org/uniprot/A0A2K5U0X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/9541:RPS24 ^@ http://purl.uniprot.org/uniprot/A0A2K5WI52|||http://purl.uniprot.org/uniprot/A0A2K5WI69|||http://purl.uniprot.org/uniprot/A0A2K5WTC9 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family.|||Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. http://togogenome.org/gene/9541:BSCL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTB2|||http://purl.uniprot.org/uniprot/Q4R5X7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:MTCL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKQ5 ^@ Similarity ^@ Belongs to the SOGA family. http://togogenome.org/gene/9541:STX5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XE24|||http://purl.uniprot.org/uniprot/G7PPS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Membrane http://togogenome.org/gene/9541:ADIPOR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9541:SPRR1B ^@ http://purl.uniprot.org/uniprot/G7NUF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornifin (SPRR) family.|||Cytoplasm http://togogenome.org/gene/9541:TM9SF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9541:NUF2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YDP9|||http://purl.uniprot.org/uniprot/G7NU22 ^@ Similarity ^@ Belongs to the NUF2 family. http://togogenome.org/gene/9541:CDC45 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC45 family.|||Nucleus http://togogenome.org/gene/9541:HCAR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULI6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:CHCHD7 ^@ http://purl.uniprot.org/uniprot/Q8SPI2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CHCHD7 family.|||Mitochondrion intermembrane space|||Monomer. http://togogenome.org/gene/9541:LOC102136717 ^@ http://purl.uniprot.org/uniprot/A0A7N9CT39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMAGP family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9541:EDC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDI2|||http://purl.uniprot.org/uniprot/G7P942|||http://purl.uniprot.org/uniprot/Q4R8V9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EDC3 family.|||Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping (By similarity).|||Homodimer (via YjeF N-terminal domain). Forms a complex with DCP1A, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with DCP1A and DDX6. Interacts with ZFP36.|||P-body|||The DFDF domain is unstructured by itself. It assumes a helical fold upon interaction with DDX6 (By similarity). http://togogenome.org/gene/9541:MAD1L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQN7|||http://purl.uniprot.org/uniprot/A0A2K5WQR5 ^@ Similarity ^@ Belongs to the MAD1 family. http://togogenome.org/gene/9541:C6H5orf22 ^@ http://purl.uniprot.org/uniprot/A0A2K5UT40|||http://purl.uniprot.org/uniprot/G7P7B1|||http://purl.uniprot.org/uniprot/I7GH47 ^@ Similarity ^@ Belongs to the UPF0489 family. http://togogenome.org/gene/9541:PPIE ^@ http://purl.uniprot.org/uniprot/Q4R675 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.|||Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. http://togogenome.org/gene/9541:TLL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8M4|||http://purl.uniprot.org/uniprot/A0A2K5U8R3 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PNPO ^@ http://purl.uniprot.org/uniprot/A0A2K5X2W4|||http://purl.uniprot.org/uniprot/Q4R6R7 ^@ Function|||Similarity ^@ Belongs to the pyridoxamine 5'-phosphate oxidase family.|||Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). http://togogenome.org/gene/9541:DLGAP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1A5|||http://purl.uniprot.org/uniprot/A0A2K5V1B3|||http://purl.uniprot.org/uniprot/A0A2K5V1F4|||http://purl.uniprot.org/uniprot/A0A2K5V1M5 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9541:PHETA2 ^@ http://purl.uniprot.org/uniprot/G7PFP6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sesquipedalian family.|||Early endosome|||Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.|||Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.|||Recycling endosome|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/9541:TRIP13 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCI5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AAA ATPase family. PCH2 subfamily.|||Nucleus|||Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways.|||Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction does not require the presence of thyroid hormone for its interaction. Interacts with proteasome subunit PSMA8; to participate in meiosis progression during spermatogenesis. http://togogenome.org/gene/9541:PTPN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4U0|||http://purl.uniprot.org/uniprot/G7PN58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||May act at junctions between the membrane and the cytoskeleton.|||cytoskeleton http://togogenome.org/gene/9541:TNFSF12 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX74 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9541:STOML3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSK0 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9541:NRG4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ77 ^@ Caution|||Similarity ^@ Belongs to the neuregulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PARK7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXS5|||http://purl.uniprot.org/uniprot/A0A2K5VY13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C56 family.|||Membrane raft http://togogenome.org/gene/9541:MC4R ^@ http://purl.uniprot.org/uniprot/Q8HXX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ATRNL1. Homodimer; disulfide-linked, also forms higher order oligomers. Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production (By similarity). Interacts with MRAP and MRAP2; these associated factors increase ligand-sensitivity and generation of cAMP (By similarity).|||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). http://togogenome.org/gene/9541:TMCO5A ^@ http://purl.uniprot.org/uniprot/A0A2K5VS67|||http://purl.uniprot.org/uniprot/A0A2K5VSG9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CRYGN ^@ http://purl.uniprot.org/uniprot/A0A2K5VIL8 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9541:SIX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3Q4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SIX/Sine oculis homeobox family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:CREB3L2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAS0|||http://purl.uniprot.org/uniprot/G8F420 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family. ATF subfamily.|||Binds DNA as a dimer.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9541:MRPS6 ^@ http://purl.uniprot.org/uniprot/I7G7W8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family. http://togogenome.org/gene/9541:THTPA ^@ http://purl.uniprot.org/uniprot/A0A2K5VF89|||http://purl.uniprot.org/uniprot/G7P9W2|||http://purl.uniprot.org/uniprot/Q9BGW0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ThTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Hydrolase highly specific for thiamine triphosphate (ThTP).|||Monomer. http://togogenome.org/gene/9541:NPY1R ^@ http://purl.uniprot.org/uniprot/A0A2K5U9D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:GAPDH ^@ http://purl.uniprot.org/uniprot/A0A0A7KUP9 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/9541:PRPF31 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8Q0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP31 family.|||Cajal body http://togogenome.org/gene/9541:FABP6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX64 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:DTX4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/9541:TSHZ3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TL77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the teashirt C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9541:POU2F2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQU2|||http://purl.uniprot.org/uniprot/A0A2K5UQU5|||http://purl.uniprot.org/uniprot/A0A7N9D5B6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-2 subfamily.|||Nucleus|||Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. http://togogenome.org/gene/9541:RETREG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Membrane http://togogenome.org/gene/9541:CCR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRN1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:SULF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VH45 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Endoplasmic reticulum|||Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9541:GMPPB ^@ http://purl.uniprot.org/uniprot/A0A2K5UBH2|||http://purl.uniprot.org/uniprot/G8F4N3 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/9541:ALDH3B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TU20|||http://purl.uniprot.org/uniprot/A0A7N9CJD7 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9541:NGRN ^@ http://purl.uniprot.org/uniprot/A0A2K5VCN6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neugrin family.|||Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.|||Mitochondrion membrane|||Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system. http://togogenome.org/gene/9541:JAK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|||Cytoplasm|||Endomembrane system|||Nucleus http://togogenome.org/gene/9541:TSPAN9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDR9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PNLIPRP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5URK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9541:OSBPL7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TT73|||http://purl.uniprot.org/uniprot/A0A2K5U737|||http://purl.uniprot.org/uniprot/G7PU60 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9541:LOC101866604 ^@ http://purl.uniprot.org/uniprot/I7G5Z1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9541:HPCAL4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YKT1|||http://purl.uniprot.org/uniprot/G7NUC4 ^@ Function ^@ May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. http://togogenome.org/gene/9541:PAIP2B ^@ http://purl.uniprot.org/uniprot/A0A2K5UKQ6 ^@ Similarity ^@ Belongs to the PAIP2 family. http://togogenome.org/gene/9541:MCM6 ^@ http://purl.uniprot.org/uniprot/Q4R6V0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9541:SLC27A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2T4|||http://purl.uniprot.org/uniprot/Q4R3Y4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Endoplasmic reticulum membrane|||Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (By similarity). Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis (By similarity). Probably involved in fatty acid transport across the blood barrier (By similarity). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity). http://togogenome.org/gene/9541:MYO18A ^@ http://purl.uniprot.org/uniprot/A0A2K5W884 ^@ Caution|||Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:TM9SF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WM17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9541:NAT10 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6A0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.|||Interacts with THUMPD1.|||RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.|||nucleolus http://togogenome.org/gene/9541:GOLM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UP08|||http://purl.uniprot.org/uniprot/A0A2K5UP24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/9541:TCTN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTE9 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/9541:MCIDAS ^@ http://purl.uniprot.org/uniprot/A0A7N9DC94 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the geminin family.|||Heterodimer (via coiled-coil domain) with GMNN (via coiled-coil domain); targets GMNN to the nucleus. Can form homodimers (in vitro, via coiled-coil domain), but these are much less stable than the heterodimer formed with GMNN.|||Nucleus http://togogenome.org/gene/9541:CZIB ^@ http://purl.uniprot.org/uniprot/A0A2K5U234 ^@ Similarity ^@ Belongs to the UPF0587 family. http://togogenome.org/gene/9541:TUT4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B-like family.|||Cytoplasm http://togogenome.org/gene/9541:G6PC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:RBL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5URJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the retinoblastoma protein (RB) family.|||Nucleus http://togogenome.org/gene/9541:TDRD9 ^@ http://purl.uniprot.org/uniprot/G7PBQ1 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. http://togogenome.org/gene/9541:PRKCH ^@ http://purl.uniprot.org/uniprot/A0A2K5UP58|||http://purl.uniprot.org/uniprot/G7PAH0 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.|||Cytoplasm|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation. http://togogenome.org/gene/9541:MMP20 ^@ http://purl.uniprot.org/uniprot/A0A2K5TT27 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9541:LOC102124821 ^@ http://purl.uniprot.org/uniprot/A0A2K5UE97 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:CPNE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBZ5|||http://purl.uniprot.org/uniprot/A0A7N9CK79 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9541:RPS16 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRP5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/9541:PAQR4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9541:ANAPC15 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3R7|||http://purl.uniprot.org/uniprot/G7PR12 ^@ Similarity ^@ Belongs to the APC15 family. http://togogenome.org/gene/9541:WDR35 ^@ http://purl.uniprot.org/uniprot/A0A2K5WG25|||http://purl.uniprot.org/uniprot/A0A2K5WG69 ^@ Function|||Subcellular Location Annotation ^@ As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.|||centrosome|||cilium basal body http://togogenome.org/gene/9541:TSNAX ^@ http://purl.uniprot.org/uniprot/Q4R599 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis (By similarity).|||Belongs to the translin family.|||Golgi apparatus|||Nucleus|||Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a mutually exclusive manner (By similarity).|||Sumoylated with SUMO1.|||perinuclear region http://togogenome.org/gene/9541:GLB1L2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQ58|||http://purl.uniprot.org/uniprot/A0A2K5VQ85 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/9541:UPF3A ^@ http://purl.uniprot.org/uniprot/Q4R3M2 ^@ Similarity ^@ Belongs to the RENT3 family. http://togogenome.org/gene/9541:SLC2A7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WT05 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9541:GPR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SPG7 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7I5 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/9541:BAP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YI92|||http://purl.uniprot.org/uniprot/G7NZW2 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/9541:NKAIN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W869 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102125546 ^@ http://purl.uniprot.org/uniprot/A0A2K5WB59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-defensin family.|||Secreted http://togogenome.org/gene/9541:B3GNT7 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:DKK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMC3|||http://purl.uniprot.org/uniprot/A0A7N9IE82 ^@ Similarity ^@ Belongs to the dickkopf family. http://togogenome.org/gene/9541:C3AR1 ^@ http://purl.uniprot.org/uniprot/A0A7N9IBB4|||http://purl.uniprot.org/uniprot/Q6TAC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with VGF-derived peptide TLQP-21 (By similarity).|||Interacts with VGF-derived peptide TLQP-21.|||Membrane|||Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production (By similarity).|||Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. http://togogenome.org/gene/9541:ITGA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9541:TOM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6K2|||http://purl.uniprot.org/uniprot/A0A7N9IGN3|||http://purl.uniprot.org/uniprot/G7PFA5 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9541:KRT20 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4V1|||http://purl.uniprot.org/uniprot/G7PUQ1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:LOC102147203 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYP0 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9541:FGF16 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMM2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:TMED5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJL0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Interacts with TMED9 and TMED10.|||Membrane|||Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.|||cis-Golgi network membrane http://togogenome.org/gene/9541:ENPP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||Secreted http://togogenome.org/gene/9541:OPRM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0J7|||http://purl.uniprot.org/uniprot/A0A2K5U0S6|||http://purl.uniprot.org/uniprot/Q95M54 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Endosome|||Forms homooligomers and heterooligomers with other GPCRs, such as OPRD1, OPRK1, OPRL1, NPFFR2, ADRA2A, SSTR2, CNR1 and CCR5 (probably in dimeric forms). Interacts with heterotrimeric G proteins; interaction with a heterotrimeric complex containing GNAI1, GNB1 and GNG2 stabilizes the active conformation of the receptor and increases its affinity for endomorphin-2, the synthetic opioid peptide DAMGO and for morphinan agonists (By similarity). Interacts with PPL; the interaction disrupts agonist-mediated G-protein activation. Interacts (via C-terminus) with DNAJB4 (via C-terminus). Interacts with calmodulin; the interaction inhibits the constitutive activity of OPRM1; it abolishes basal and attenuates agonist-stimulated G-protein coupling. Interacts with FLNA, PLD2, RANBP9 and WLS and GPM6A (By similarity). Interacts with RTP4 (By similarity). Interacts with SYP and GNAS (By similarity). Interacts with RGS9, RGS17, RGS20, RGS4, PPP1R9B and HINT1.|||Membrane|||Perikaryon|||Phosphorylated. Differentially phosphorylated in basal and agonist-induced conditions. Agonist-mediated phosphorylation modulates receptor internalization. Phosphorylated by GRK2 in a agonist-dependent manner. Phosphorylation at Tyr-168 requires receptor activation, is dependent on non-receptor protein tyrosine kinase Src and results in a decrease in agonist efficacy by reducing G-protein coupling efficiency. Phosphorylated on tyrosine residues; the phosphorylation is involved in agonist-induced G-protein-independent receptor down-regulation. Phosphorylation at Ser-377 is involved in G-protein-dependent but not beta-arrestin-dependent activation of the ERK pathway (By similarity).|||Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis.|||Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.|||axon|||dendrite http://togogenome.org/gene/9541:CUL7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cullin family.|||Cytoplasm http://togogenome.org/gene/9541:PFKFB4 ^@ http://purl.uniprot.org/uniprot/Q4R8B6 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the phosphoglycerate mutase family.|||Synthesis and degradation of fructose 2,6-bisphosphate.|||The most important regulatory mechanism of these opposing activities is by phosphorylation and dephosphorylation of the enzyme. http://togogenome.org/gene/9541:CORO6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCX6|||http://purl.uniprot.org/uniprot/A0A2K5VCY7|||http://purl.uniprot.org/uniprot/A0A2K5VD52 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9541:ALDH1A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVJ1|||http://purl.uniprot.org/uniprot/A0A2K5VVS6 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9541:RDM1 ^@ http://purl.uniprot.org/uniprot/Q4R856 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ C-terminal half contains cytoplasmic retention domains as well as determinants involved in its stress-induced nucleolar accumulation.|||Cajal body|||Cytoplasm|||Homodimer.|||May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA (By similarity).|||Nucleus|||PML body|||nucleolus http://togogenome.org/gene/9541:STS ^@ http://purl.uniprot.org/uniprot/Q2XQY2 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9541:LOC102121655 ^@ http://purl.uniprot.org/uniprot/A0A7N9CXZ7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:CYP21A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ97 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:TNFRSF19 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDZ9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:BHMT ^@ http://purl.uniprot.org/uniprot/A0A8J8YGY7|||http://purl.uniprot.org/uniprot/G7P7U0 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 zinc ion per subunit.|||Homotetramer.|||Involved in the regulation of homocysteine metabolism. http://togogenome.org/gene/9541:C10H20orf27 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJK1|||http://purl.uniprot.org/uniprot/A0A2K5UJP1|||http://purl.uniprot.org/uniprot/G7PGV4|||http://purl.uniprot.org/uniprot/I7GL62 ^@ Similarity ^@ Belongs to the UPF0687 family. http://togogenome.org/gene/9541:VANGL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SQLE ^@ http://purl.uniprot.org/uniprot/Q2PFM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:C1S ^@ http://purl.uniprot.org/uniprot/A0A2K5VQX9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC102125235 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGG3 ^@ Similarity ^@ Belongs to the SPAN-X family. http://togogenome.org/gene/9541:RAD51 ^@ http://purl.uniprot.org/uniprot/A0A2K5VN96|||http://purl.uniprot.org/uniprot/A0A2K5VNC1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Belongs to the RecA family. RAD51 subfamily.|||Nucleus|||Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair. http://togogenome.org/gene/9541:KCNQ5 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4T1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:SLC6A13 ^@ http://purl.uniprot.org/uniprot/A0A2K5TN47|||http://purl.uniprot.org/uniprot/G7PJJ2|||http://purl.uniprot.org/uniprot/Q2PG55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.|||Cell membrane|||Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (By similarity). Can also mediate transport of beta-alanine, taurine and hypotaurine (By similarity).|||Membrane http://togogenome.org/gene/9541:KDM1B ^@ http://purl.uniprot.org/uniprot/A0A2K5W5G6 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9541:SNRPA ^@ http://purl.uniprot.org/uniprot/G7PXM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM U1 A/B'' family.|||Nucleus http://togogenome.org/gene/9541:GRIA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UF45|||http://purl.uniprot.org/uniprot/A0A2K5UF55|||http://purl.uniprot.org/uniprot/A0A2K5UFB7|||http://purl.uniprot.org/uniprot/A0A8J8YCD6|||http://purl.uniprot.org/uniprot/G7Q3M1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9541:ITFG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMQ9 ^@ Similarity ^@ Belongs to the TIP family. http://togogenome.org/gene/9541:TUT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UA61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B-like family.|||Nucleus speckle|||nucleolus http://togogenome.org/gene/9541:TPH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAQ7 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9541:LOC102141433 ^@ http://purl.uniprot.org/uniprot/A0A7N9DET8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 6A family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:SUV39H2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UW31|||http://purl.uniprot.org/uniprot/A0A2K5UW32|||http://purl.uniprot.org/uniprot/Q4R3E0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates in stable binding to heterochromatin (By similarity).|||Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (By similarity).|||In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.|||Interacts with SMAD5. The large PER complex involved in the histone methylation is composed of at least PER2, CBX3, TRIM28, SUV39H1 and/or SUV39H2; CBX3 mediates the formation of the complex (By similarity).|||Nucleus|||centromere http://togogenome.org/gene/9541:NKD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNX7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NKD family.|||Cell autonomous antagonist of the canonical Wnt signaling pathway.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:SLC16A6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XB19|||http://purl.uniprot.org/uniprot/G7PV86 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:RGS5 ^@ http://purl.uniprot.org/uniprot/Q4R5E0 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. http://togogenome.org/gene/9541:SCOC ^@ http://purl.uniprot.org/uniprot/A0A2K5TUE0|||http://purl.uniprot.org/uniprot/A0A7N9CUY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SCOC family.|||Positive regulator of amino acid starvation-induced autophagy.|||trans-Golgi network http://togogenome.org/gene/9541:OSGEPL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXY0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Mitochondrion|||Monomer.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. http://togogenome.org/gene/9541:GNB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWG1|||http://purl.uniprot.org/uniprot/G7NZ30 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9541:SELL ^@ http://purl.uniprot.org/uniprot/A0A2K5W1G2|||http://purl.uniprot.org/uniprot/A0A7N9DE02 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the selectin/LECAM family.|||Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.|||Cell membrane|||Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:DPY30 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRJ2|||http://purl.uniprot.org/uniprot/G7PLZ5 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/9541:LRRFIP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBU9|||http://purl.uniprot.org/uniprot/A0A2K5VBV9 ^@ Similarity ^@ Belongs to the LRRFIP family. http://togogenome.org/gene/9541:TNFRSF10B ^@ http://purl.uniprot.org/uniprot/A0A2K5TXJ8|||http://purl.uniprot.org/uniprot/A0A2K5TXK0 ^@ Caution|||Function ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. http://togogenome.org/gene/9541:NKX2-6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZW6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ERH ^@ http://purl.uniprot.org/uniprot/A0A2K5U2F3 ^@ Function|||Similarity ^@ Belongs to the E(R) family.|||May have a role in the cell cycle. http://togogenome.org/gene/9541:CTSC ^@ http://purl.uniprot.org/uniprot/Q60HG6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C1 family.|||Binds 1 Cl(-) ion per heavy chain.|||Lysosome|||Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.|||Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function (By similarity). http://togogenome.org/gene/9541:CLUAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5E5|||http://purl.uniprot.org/uniprot/G7Q0C9|||http://purl.uniprot.org/uniprot/Q4R6Y7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CLUAP1 family.|||Interacts with CLU/clusterin. Interacts with UBXN10; the interaction is direct.|||Nucleus|||Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling.|||cilium http://togogenome.org/gene/9541:SND1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL07|||http://purl.uniprot.org/uniprot/A0A8J8XDP7|||http://purl.uniprot.org/uniprot/G7P0L2 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. http://togogenome.org/gene/9541:TAS2R41 ^@ http://purl.uniprot.org/uniprot/G7P1I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9541:SDF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X223|||http://purl.uniprot.org/uniprot/Q4R585 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CREC family.|||Binds calcium via its EF-hands.|||Golgi apparatus lumen|||May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. http://togogenome.org/gene/9541:SUFU ^@ http://purl.uniprot.org/uniprot/A0A2K5WNJ5|||http://purl.uniprot.org/uniprot/G7PDV2|||http://purl.uniprot.org/uniprot/Q4R7F4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUFU family.|||Cytoplasm|||Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).|||Nucleus http://togogenome.org/gene/9541:PTAFR ^@ http://purl.uniprot.org/uniprot/A0A2K5UPJ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane|||Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9541:DDX54 ^@ http://purl.uniprot.org/uniprot/A0A2K5VH50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.|||nucleolus http://togogenome.org/gene/9541:LOC102136451 ^@ http://purl.uniprot.org/uniprot/A0A2K5WH85 ^@ Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family. http://togogenome.org/gene/9541:IRF9 ^@ http://purl.uniprot.org/uniprot/A0A2K5U899|||http://purl.uniprot.org/uniprot/I7GLB4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:LOC102116945 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/9541:CPM ^@ http://purl.uniprot.org/uniprot/A0A2K5TSF2 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9541:THRA ^@ http://purl.uniprot.org/uniprot/I7GJD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9541:LOC102143773 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0I8 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. http://togogenome.org/gene/9541:CLDND1 ^@ http://purl.uniprot.org/uniprot/Q4R4Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9541:TRAPPC13 ^@ http://purl.uniprot.org/uniprot/A0A2K5X667|||http://purl.uniprot.org/uniprot/A0A2K5X6A3 ^@ Similarity|||Subunit ^@ Belongs to the TRAPPC13 family.|||Part of the multisubunit TRAPP (transport protein particle) complex. http://togogenome.org/gene/9541:P3H1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6Q6 ^@ Similarity ^@ Belongs to the leprecan family. http://togogenome.org/gene/9541:SLC25A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6E8|||http://purl.uniprot.org/uniprot/I7G9S2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Interacts with PPIF; the interaction is impaired by CsA.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ADRB1 ^@ http://purl.uniprot.org/uniprot/U6BY78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:UIMC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAP80 family.|||Nucleus http://togogenome.org/gene/9541:ECI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTI7|||http://purl.uniprot.org/uniprot/A0A2K5TTJ3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9541:HOXC8 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y903|||http://purl.uniprot.org/uniprot/G7PHW1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SLC7A1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XU70|||http://purl.uniprot.org/uniprot/G7PVY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102118946 ^@ http://purl.uniprot.org/uniprot/A0A7N9DA28|||http://purl.uniprot.org/uniprot/Q95K74 ^@ Function|||PTM|||Subcellular Location Annotation ^@ Acts as a ligand for PILRA in neuronal tissues, where it may be involved in immune regulation.|||Membrane|||O-glycosylation at Thr-140 is essential for recognition by PILRA. http://togogenome.org/gene/9541:DBNL ^@ http://purl.uniprot.org/uniprot/I7GJL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABP1 family.|||Cell membrane|||Early endosome|||Endosome|||Golgi apparatus membrane|||Perikaryon|||Postsynaptic density|||Synapse|||cell cortex|||clathrin-coated vesicle membrane|||cytoskeleton|||dendrite|||lamellipodium|||neuron projection|||podosome|||ruffle http://togogenome.org/gene/9541:KYNU ^@ http://purl.uniprot.org/uniprot/A0A2K5WUC6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PUF60 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFX0|||http://purl.uniprot.org/uniprot/A0A2K5VG32|||http://purl.uniprot.org/uniprot/A0A2K5VG43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM half pint family.|||Nucleus http://togogenome.org/gene/9541:XPC ^@ http://purl.uniprot.org/uniprot/A0A2K5UY98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPC family.|||Nucleus http://togogenome.org/gene/9541:MIF ^@ http://purl.uniprot.org/uniprot/Q4R549 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MIF family.|||Cytoplasm|||Homotrimer (By similarity). Interacts with CXCR2 extracellular domain (By similarity). Interacts with the CD74 extracellular domain, USO1, COPS5 and BNIPL (By similarity).|||Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.|||Secreted http://togogenome.org/gene/9541:NGB ^@ http://purl.uniprot.org/uniprot/A0A7N9CWQ6 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9541:ARV1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YFP4|||http://purl.uniprot.org/uniprot/G7NXK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane http://togogenome.org/gene/9541:TMEM245 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKF6|||http://purl.uniprot.org/uniprot/A0A7N9IC78|||http://purl.uniprot.org/uniprot/A0A7N9ICT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/9541:PRMT5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U736|||http://purl.uniprot.org/uniprot/A0A2K5U799|||http://purl.uniprot.org/uniprot/A0A2K5U7A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).|||Belongs to the class I-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:ALDH4A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6Q8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9541:FAM199X ^@ http://purl.uniprot.org/uniprot/A0A2K5X7I9 ^@ Similarity ^@ Belongs to the FAM199 family. http://togogenome.org/gene/9541:TRMT11 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYZ9 ^@ Function|||Subunit ^@ Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.|||Interacts with TRMT112. http://togogenome.org/gene/9541:LOC102132662 ^@ http://purl.uniprot.org/uniprot/F8RBU3 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9541:DDX28 ^@ http://purl.uniprot.org/uniprot/Q4R4T6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DEAD box helicase family.|||Mitochondrion|||Mitosome matrix|||Monomer. Found in a complex with GRSF1, DHX30, FASTKD2 and FASTKD5. Associates with the 16S mitochondrial rRNA (16S mt-rRNA) and with the mitochondrial ribosome large subunit (39S).|||Nucleus|||Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (By similarity).|||mitochondrion nucleoid http://togogenome.org/gene/9541:LCA5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6G4 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/9541:ATP5MG ^@ http://purl.uniprot.org/uniprot/A0A2K5WDC2|||http://purl.uniprot.org/uniprot/A0A7N9DCI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase g subunit family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion http://togogenome.org/gene/9541:COPE ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPE family.|||Cytoplasm|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. http://togogenome.org/gene/9541:SDHAF4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YBD7|||http://purl.uniprot.org/uniprot/G7P2Z8 ^@ Similarity ^@ Belongs to the SDHAF4 family. http://togogenome.org/gene/9541:LOC102133057 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN81 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRQ/QCR8 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:LASP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJN2|||http://purl.uniprot.org/uniprot/A0A7N9IBC7 ^@ Function|||Subcellular Location Annotation ^@ Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9541:IRX6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/9541:RIBC2 ^@ http://purl.uniprot.org/uniprot/Q4R9D8 ^@ Similarity ^@ Belongs to the RIB43A family. http://togogenome.org/gene/9541:CYP2A24 ^@ http://purl.uniprot.org/uniprot/A8CBQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:LOC102125891 ^@ http://purl.uniprot.org/uniprot/A0A2K5X524 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LGI3 ^@ http://purl.uniprot.org/uniprot/Q4R4H3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with STX1A.|||May participate in the regulation of neuronal exocytosis.|||Secreted|||synaptic vesicle|||synaptosome http://togogenome.org/gene/9541:SFXN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane http://togogenome.org/gene/9541:PLA2G12A ^@ http://purl.uniprot.org/uniprot/A0A2K5TPG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/9541:PLOD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMG9|||http://purl.uniprot.org/uniprot/A0A2K5WMI3|||http://purl.uniprot.org/uniprot/A0A2K5WMZ3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9541:THOC6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XWH0|||http://purl.uniprot.org/uniprot/G7Q0B3 ^@ Similarity ^@ Belongs to the WD repeat THOC6 family. http://togogenome.org/gene/9541:BMP7 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0V5 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9541:TCN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9541:CNN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIP8 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/9541:IREB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X545 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Cytoplasm|||RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. http://togogenome.org/gene/9541:EHD4 ^@ http://purl.uniprot.org/uniprot/A0A7N9DAY1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9541:CD9 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/9541:SESN1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XG88|||http://purl.uniprot.org/uniprot/Q4R6P7|||http://purl.uniprot.org/uniprot/Q4R7Y6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sestrin family.|||Cytoplasm|||Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed.|||Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is negatively regulated by leucine. Interacts with RRAGA, RRAGB, RRAGC and RRAGD; may function as a guanine nucleotide dissociation inhibitor for RRAGs and regulate them. Interacts with KEAP1, RBX1 and SQSTM1; in the SQSTM1-dependent autophagic degradation of KEAP1. May interact with PRDX1.|||Nucleus|||The C-terminal domain mediates interaction with GATOR2 through which it regulates TORC1 signaling.|||The N-terminal domain may have an alkylhydroperoxide reductase activity. http://togogenome.org/gene/9541:FLT4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane|||Nucleus http://togogenome.org/gene/9541:SETDB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3M8|||http://purl.uniprot.org/uniprot/G7PVE8 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9541:LOC102140578 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4Q6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:LOC102127615 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SLC13A1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2D1|||http://purl.uniprot.org/uniprot/G7P0J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9541:TM7SF2 ^@ http://purl.uniprot.org/uniprot/I7GPM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/9541:GPRC5B ^@ http://purl.uniprot.org/uniprot/I7GMR6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:ACTL7B ^@ http://purl.uniprot.org/uniprot/Q95JK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||cytoskeleton http://togogenome.org/gene/9541:SSTR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:POPDC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WX81|||http://purl.uniprot.org/uniprot/A0A2K5WX93|||http://purl.uniprot.org/uniprot/A0A2K5WXT7 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9541:LOC102134176 ^@ http://purl.uniprot.org/uniprot/Q9TSM6 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the protein-tyrosine phosphatase family.|||Cell membrane|||Cytoplasm|||Early endosome|||Endoplasmic reticulum|||Farnesylated. Farnesylation is required for membrane targeting (By similarity).|||Homotrimer. Interacts with ATF5 and tubulin (By similarity).|||In the retina, expressed by red/green- but not blue-sensitive cone photoreceptor cells, and by rod bipolar cells (at protein level).|||Inhibited by sodium orthovanadate and pentamidine.|||Nucleus|||Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity).|||spindle http://togogenome.org/gene/9541:TOP3A ^@ http://purl.uniprot.org/uniprot/A0A2K5VKN3 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/9541:NR1H2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X889|||http://purl.uniprot.org/uniprot/A0A2K5X8M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9541:SLC15A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Membrane http://togogenome.org/gene/9541:MAP1LC3A ^@ http://purl.uniprot.org/uniprot/I7GLL6 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9541:MAML3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mastermind family.|||Nucleus speckle http://togogenome.org/gene/9541:SEPTIN7 ^@ http://purl.uniprot.org/uniprot/Q4R521 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Filament-forming cytoskeletal GTPase.|||Midbody|||Septins polymerize into heterooligomeric protein complexes that form filaments.|||cilium axoneme|||flagellum|||kinetochore|||spindle http://togogenome.org/gene/9541:ASB8 ^@ http://purl.uniprot.org/uniprot/A0A8J8XBK7|||http://purl.uniprot.org/uniprot/G7PHQ2 ^@ Function|||Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family.|||May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9541:RABGGTB ^@ http://purl.uniprot.org/uniprot/A0A2K5WEG7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX. http://togogenome.org/gene/9541:ODF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUM7|||http://purl.uniprot.org/uniprot/A0A2K5TUQ3|||http://purl.uniprot.org/uniprot/A0A2K5TUY9|||http://purl.uniprot.org/uniprot/G7PRF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||centrosome http://togogenome.org/gene/9541:APOC2 ^@ http://purl.uniprot.org/uniprot/A2V9Y5|||http://purl.uniprot.org/uniprot/P18658 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C2 family.|||Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase.|||Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.|||Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.|||Secreted http://togogenome.org/gene/9541:PPP3R2 ^@ http://purl.uniprot.org/uniprot/Q4R8E1 ^@ Similarity ^@ Belongs to the calcineurin regulatory subunit family. http://togogenome.org/gene/9541:FKTN ^@ http://purl.uniprot.org/uniprot/A0A2K5VBG3|||http://purl.uniprot.org/uniprot/A0A7N9D6T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LicD transferase family.|||Golgi apparatus membrane http://togogenome.org/gene/9541:CHURC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSH3 ^@ Similarity ^@ Belongs to the Churchill family. http://togogenome.org/gene/9541:KDM5B ^@ http://purl.uniprot.org/uniprot/A0A2K5UHD5 ^@ Similarity ^@ Belongs to the JARID1 histone demethylase family. http://togogenome.org/gene/9541:NDUFA11 ^@ http://purl.uniprot.org/uniprot/I7G4S4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA11 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:CLUL1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CZN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clusterin family.|||Secreted http://togogenome.org/gene/9541:CCT8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VA28|||http://purl.uniprot.org/uniprot/Q4R5J0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG (By similarity). Interacts with DNAAF4 (By similarity).|||Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.|||Cytoplasm|||centrosome|||cilium basal body http://togogenome.org/gene/9541:OPRL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.|||Membrane|||Vesicle http://togogenome.org/gene/9541:GLIPR1 ^@ http://purl.uniprot.org/uniprot/I7GIK2 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/9541:CA7 ^@ http://purl.uniprot.org/uniprot/A0A2K5U255 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9541:TNFAIP6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XIV1|||http://purl.uniprot.org/uniprot/G7PKK5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:CCND1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin D subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:RNASEH2A ^@ http://purl.uniprot.org/uniprot/A0A2K5TX28|||http://purl.uniprot.org/uniprot/A0A7N9IAX6 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family. Eukaryotic subfamily.|||Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/9541:LOC102137778 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SAR1B ^@ http://purl.uniprot.org/uniprot/A0A2K5W6R3 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family.|||Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9541:FBXL5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEY4 ^@ Subcellular Location Annotation ^@ perinuclear region http://togogenome.org/gene/9541:CCR7 ^@ http://purl.uniprot.org/uniprot/C0ISS3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:NSMCE4A ^@ http://purl.uniprot.org/uniprot/A0A2K5X6C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE4 family.|||Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.|||Component of the SMC5-SMC6 complex.|||Nucleus|||telomere http://togogenome.org/gene/9541:USP49 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLW2 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9541:TRPC5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XXH1|||http://purl.uniprot.org/uniprot/G7Q3H5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ARRDC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WR30 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9541:PTGES3 ^@ http://purl.uniprot.org/uniprot/I7GKX7|||http://purl.uniprot.org/uniprot/Q25KC4|||http://purl.uniprot.org/uniprot/Q6PWL5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the p23/wos2 family.|||Cytoplasm|||Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.|||Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.|||Detected in granulosa cells of periovulatory follicles. Detected at high levels in lung, and at lower levels in endometrium, ovary, myometrium, oviduct and liver (at protein level). Detected in endometrium, myometrium, oviduct and ovary, and at low levels in liver and lung.|||Forms a complex with HSP70, HSP90 and other chaperones.|||Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2. Binds to the progesterone receptor. Interacts with TERT; the interaction, together with HSP90AA1, is required for correct assembly and stabilization of the telomerase holoenzyme complex. Interacts (via PXLE motif) with EGLN1/PHD2, recruiting EGLN1/PHD2 to the HSP90 pathway to facilitate HIF alpha proteins hydroxylation. Interacts with HSP90AA1, FLCN, FNIP1 and FNIP2.|||Proteolytically cleaved by caspase-7 (CASP7) in response to apoptosis, leading to its inactivation. http://togogenome.org/gene/9541:SRP14 ^@ http://purl.uniprot.org/uniprot/Q4R5C7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP14 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (By similarity). The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity).|||Cytoplasm|||Heterodimer with SRP9; binds RNA as heterodimer (By similarity). Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity). http://togogenome.org/gene/9541:SORD ^@ http://purl.uniprot.org/uniprot/G7PB87|||http://purl.uniprot.org/uniprot/Q4R639 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the zinc-containing alcohol dehydrogenase family.|||Binds 1 or 2 Zn(2+) ions per subunit.|||Binds 1 zinc ion per subunit.|||Homotetramer.|||Mitochondrion membrane|||Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility.|||Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2-oxidized products D-xylulose, L-sorbose and D-fructose, respectively (By similarity). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity).|||flagellum http://togogenome.org/gene/9541:CASS4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRI2|||http://purl.uniprot.org/uniprot/A0A2K5TRK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/9541:ME2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDY8 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/9541:LOC102124928 ^@ http://purl.uniprot.org/uniprot/G7P1K8|||http://purl.uniprot.org/uniprot/Q4W7G9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9541:OSMR ^@ http://purl.uniprot.org/uniprot/A0A2K5UFW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9541:LOC102139187 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1F0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.|||Secreted http://togogenome.org/gene/9541:FFAR4 ^@ http://purl.uniprot.org/uniprot/C8YUV0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Endosome membrane|||G-protein-coupled receptor for long-chain fatty acids (LCFAs) with a major role in adipogenesis, energy metabolism and inflammation. Signals via G-protein and beta-arrestin pathways. LCFAs sensing initiates activation of phosphoinositidase C-linked G proteins GNAQ and GNA11 (G(q)/G(11)), inducing a variety of cellular responses via second messenger pathways such as intracellular calcium mobilization, modulation of cyclic adenosine monophosphate (cAMP) production, and mitogen-activated protein kinases (MAPKs). After LCFAs binding, associates with beta-arrestin ARRB2 that acts as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis (By similarity). In response to dietary fats, plays an important role in the regulation of adipocyte proliferation and differentiation. Acts as a receptor for omega-3 polyunsaturated fatty acids (PUFAs) at primary cilium of perivascular preadipocytes, initiating an adipogenic program via cAMP and CTCF-dependent chromatin remodeling that ultimately results in transcriptional activation of adipogenic genes and cell cycle entry. Induces differentiation of brown and beige adipocytes probably via autocrine and endocrine functions of FGF21 hormone. Contributes to the thermogenic activation of brown adipose tissue and the browning of white adipose tissue. Activates brown adipocytes by initiating intracellular calcium signaling leading to mitochondrial depolarization and fission, and overall increased mitochondrial respiration. Consequently stimulates fatty acid uptake and oxidation in mitochondria together with UCP1-mediated thermogenic respiration, eventually reducing fat mass. Regulates bi-potential differentiation of bone marrow mesenchymal stem cells toward osteoblasts or adipocytes likely by up-regulating distinct integrins. In response to dietary fats regulates hormone secretion and appetite. Stimulates GIP and GLP1 secretion from enteroendocrine cells as well as GCG secretion in pancreatic alpha cells, thereby playing a role in the regulation of blood glucose levels. Negatively regulates glucose-induced SST secretion in pancreatic delta cells. Mediates LCFAs inhibition of GHRL secretion, an appetite-controlling hormone. In taste buds, contributes to sensing of dietary fatty acids by the gustatory system. During the inflammatory response, promotes anti-inflammatory M2 macrophage differentiation in adipose tissue (By similarity). Mediates the anti-inflammatory effects of omega-3 PUFAs via inhibition of NLRP3 inflammasome activation (By similarity). In this pathway, interacts with adapter protein ARRB2 and inhibits the priming step triggered by Toll-like receptors (TLRs) at the level of TAK1 and TAB1 (By similarity). Further inhibits the activation step when ARRB2 directly associates with NLRP3, leading to inhibition of pro-inflammatory cytokine release (By similarity). Mediates LCFAs anti-apoptotic effects (By similarity).|||Highly expressed in lung and colon.|||Interacts (via C-terminus) with ARRB2 following LCFAs stimulation.|||Lysosome membrane|||Phosphorylated at two clusters of Ser and Thr residues located in the intracellular C-terminus. Prerequisite for FFAR4 internalization via an ARRB2-dependent pathway.|||cilium membrane http://togogenome.org/gene/9541:CXCL6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9541:LOC102127733 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SESN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZF6|||http://purl.uniprot.org/uniprot/Q4R751 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9541:ESR1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XH51|||http://purl.uniprot.org/uniprot/G7P4Y2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Binds DNA as a homodimer.|||Nucleus|||The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. http://togogenome.org/gene/9541:LOC102122786 ^@ http://purl.uniprot.org/uniprot/A0A2K5UP00 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9541:C9H10orf53 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMA8 ^@ Similarity ^@ Belongs to the UPF0728 family. http://togogenome.org/gene/9541:CAMK1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5C5|||http://purl.uniprot.org/uniprot/G7NYU8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:ARSI ^@ http://purl.uniprot.org/uniprot/A0A2K5WH83 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9541:CDNF ^@ http://purl.uniprot.org/uniprot/A0A8J8YCX8|||http://purl.uniprot.org/uniprot/G7PEE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARMET family.|||Secreted http://togogenome.org/gene/9541:APC ^@ http://purl.uniprot.org/uniprot/A0A2K5WV06|||http://purl.uniprot.org/uniprot/A0A2K5WVD6|||http://purl.uniprot.org/uniprot/A0A2K5WVL8 ^@ Similarity ^@ Belongs to the adenomatous polyposis coli (APC) family. http://togogenome.org/gene/9541:GFUS ^@ http://purl.uniprot.org/uniprot/A0A2K5VS94|||http://purl.uniprot.org/uniprot/G7PD36 ^@ Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.|||Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. http://togogenome.org/gene/9541:ZC3H12C ^@ http://purl.uniprot.org/uniprot/A0A2K5VXU9|||http://purl.uniprot.org/uniprot/G7PNR6 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/9541:RPS27A ^@ http://purl.uniprot.org/uniprot/Q4R580 ^@ Function|||Similarity|||Subunit ^@ Component of the 40S subunit of the ribosome.|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Ribosomal protein S27a is part of the 40S ribosomal subunit. http://togogenome.org/gene/9541:TMC7 ^@ http://purl.uniprot.org/uniprot/Q4R7U0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane|||Probable ion channel. http://togogenome.org/gene/9541:REEP6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WR67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/9541:HS3ST2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNA8 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9541:YWHAQ ^@ http://purl.uniprot.org/uniprot/A0A7N9DCE6 ^@ Function|||Similarity ^@ Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.|||Belongs to the 14-3-3 family. http://togogenome.org/gene/9541:RPS29 ^@ http://purl.uniprot.org/uniprot/A0A2K5WR94 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9541:CLRN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VT50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9541:BCL7A ^@ http://purl.uniprot.org/uniprot/A0A2K5VSD8 ^@ Similarity ^@ Belongs to the BCL7 family. http://togogenome.org/gene/9541:DEUP1 ^@ http://purl.uniprot.org/uniprot/G7PNG4|||http://purl.uniprot.org/uniprot/Q95JK1 ^@ Function|||Sequence Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CEP63 family.|||Contaminating sequence. Potential poly-A sequence. The C-terminus was extended based on orthologous sequences.|||Cytoplasm|||Interacts with CEP152; the interaction is mutually exclusive with CEP63.|||Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity). http://togogenome.org/gene/9541:GALNT6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UX37|||http://purl.uniprot.org/uniprot/G8F487 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:RAP2C ^@ http://purl.uniprot.org/uniprot/A0A2K5V0X8|||http://purl.uniprot.org/uniprot/G8F3L7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9541:ANK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRI0|||http://purl.uniprot.org/uniprot/A0A2K5VRS4 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9541:SNX17 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0R5|||http://purl.uniprot.org/uniprot/A0A8J8YBZ6|||http://purl.uniprot.org/uniprot/G7PLW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9541:LOC102118143 ^@ http://purl.uniprot.org/uniprot/A0A2K5UET7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:CCR8 ^@ http://purl.uniprot.org/uniprot/A0A8J8XUI3|||http://purl.uniprot.org/uniprot/G7NYJ2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:SLC27A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2A2 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9541:TMSB15B ^@ http://purl.uniprot.org/uniprot/A0A8J8XD17|||http://purl.uniprot.org/uniprot/G7Q3A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9541:ACADM ^@ http://purl.uniprot.org/uniprot/A0A2K5V3T1|||http://purl.uniprot.org/uniprot/A0A2K5V3V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9541:CASP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1I1 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9541:SUPT4H1 ^@ http://purl.uniprot.org/uniprot/Q4R941 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SPT4 family.|||Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity).|||Interacts with SUPT5H to form DSIF. DSIF interacts with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (CCNT1 or CCNT2). DSIF interacts with RNA polymerase II, and this interaction is reduced by phosphorylation of the C-terminal domain (CTD) of POLR2A by P-TEFb. DSIF also interacts with the NELF complex, which is composed of NELFA, NELFB, NELFD and NELFE, and this interaction occurs following prior binding of DSIF to RNA polymerase II. DSIF also interacts with PRMT1/HRMT1L2, HTATSF1/TATSF1, RNGTT/CAP1A, PRMT5/SKB1, SUPT6H, and can interact with PIN1 (By similarity).|||Nucleus http://togogenome.org/gene/9541:CHRD ^@ http://purl.uniprot.org/uniprot/A0A2K5TVZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chordin family.|||Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.|||Secreted http://togogenome.org/gene/9541:SHQ1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2F4 ^@ Similarity ^@ Belongs to the SHQ1 family. http://togogenome.org/gene/9541:UBXN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTT1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:CRTC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TORC family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:CASD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PC-esterase family. CASD1 subfamily.|||Membrane http://togogenome.org/gene/9541:EPB41 ^@ http://purl.uniprot.org/uniprot/A0A2K5WV60|||http://purl.uniprot.org/uniprot/A0A2K5WV95|||http://purl.uniprot.org/uniprot/A0A2K5WVN3 ^@ Subcellular Location Annotation ^@ Nucleus|||cell cortex http://togogenome.org/gene/9541:TPK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VA75 ^@ Similarity ^@ Belongs to the thiamine pyrophosphokinase family. http://togogenome.org/gene/9541:DUSP10 ^@ http://purl.uniprot.org/uniprot/A0A8J8XX38|||http://purl.uniprot.org/uniprot/G7NTY0 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9541:GNAT2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJM5|||http://purl.uniprot.org/uniprot/G7NW35 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9541:TREM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHG8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102141029 ^@ http://purl.uniprot.org/uniprot/A0A2K5UG77|||http://purl.uniprot.org/uniprot/G7PVW5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9541:MCOLN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUX9|||http://purl.uniprot.org/uniprot/A0A7N9CSJ3 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9541:OGDH ^@ http://purl.uniprot.org/uniprot/A0A2K5VYC4|||http://purl.uniprot.org/uniprot/A0A2K5VYI5|||http://purl.uniprot.org/uniprot/A0A2K5VYM0|||http://purl.uniprot.org/uniprot/A0A2K5VYN1 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/9541:ATAD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHI4 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9541:DRAM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W012|||http://purl.uniprot.org/uniprot/G7PJB5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:DERL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6I5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/9541:REEP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W174 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:CAMSAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVP2|||http://purl.uniprot.org/uniprot/A0A2K5WVP7 ^@ Domain|||Similarity ^@ Belongs to the CAMSAP1 family.|||The CKK domain binds microtubules. http://togogenome.org/gene/9541:DIPK2B ^@ http://purl.uniprot.org/uniprot/A0A2K5VAC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/9541:LOC102144965 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULV2 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:HGF ^@ http://purl.uniprot.org/uniprot/C9E9X6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. http://togogenome.org/gene/9541:B4GALT5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U705 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9541:GDPGP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIS4|||http://purl.uniprot.org/uniprot/Q8HXE4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GDPGP1 family.|||Cytoplasm|||Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.|||The orthologs in A.thaliana catalyze the first reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants. http://togogenome.org/gene/9541:SBNO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZM4|||http://purl.uniprot.org/uniprot/A0A2K5UZV1 ^@ Similarity ^@ Belongs to the SBNO family. http://togogenome.org/gene/9541:LOC102137557 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSB9 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/9541:TEAD1 ^@ http://purl.uniprot.org/uniprot/G7PQP6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102115783 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PROC ^@ http://purl.uniprot.org/uniprot/A0A2K5VQK4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:STK32A ^@ http://purl.uniprot.org/uniprot/A0A2K5UD14 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:PRR15 ^@ http://purl.uniprot.org/uniprot/A0A8J8YSC4|||http://purl.uniprot.org/uniprot/G7P0H8 ^@ Similarity ^@ Belongs to the PRR15 family. http://togogenome.org/gene/9541:POU6F1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9541:ERI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V361 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:LOC101866922 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU22|||http://purl.uniprot.org/uniprot/A0A2K5UU73 ^@ Function|||Subcellular Location Annotation ^@ Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.|||Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.|||Secreted http://togogenome.org/gene/9541:SLF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0G2|||http://purl.uniprot.org/uniprot/G7PDS0 ^@ Similarity ^@ Belongs to the FAM178 family. http://togogenome.org/gene/9541:LOC101926836 ^@ http://purl.uniprot.org/uniprot/I7G9T7 ^@ Similarity ^@ Belongs to the NKAP family. http://togogenome.org/gene/9541:NDUFA4 ^@ http://purl.uniprot.org/uniprot/Q4R542 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex IV NDUFA4 subunit family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with RAB5IF (By similarity).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. NDUFA4 is required for complex IV maintenance.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ITGA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9541:LOC101925149 ^@ http://purl.uniprot.org/uniprot/A0A7N9D0E2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AMY1 family.|||Nucleus http://togogenome.org/gene/9541:DYRK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUQ4|||http://purl.uniprot.org/uniprot/A0A2K5WUR5|||http://purl.uniprot.org/uniprot/Q4R6S5 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.|||Cytoplasm|||Cytoplasmic granule|||Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material. Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues. Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1. Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3. Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis. Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling. When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling. Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis.|||Interacts with SIRT1.|||Nucleus|||Nucleus speckle|||Protein kinase activity is activated following autophosphorylation at Tyr-349.|||Protein kinase activity is activated following autophosphorylation at Tyr-349. Autophosphorylation at Ser-330 stabilizes the protein and enhances the protein kinase activity.|||The N-terminal domain, which is intrinsically disordered, is required for stress granule localization.|||Ubiquitinated at anaphase by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome.|||centrosome http://togogenome.org/gene/9541:DHTKD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4J4 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/9541:DPCD ^@ http://purl.uniprot.org/uniprot/A0A2K5TMH4|||http://purl.uniprot.org/uniprot/G7PDT2|||http://purl.uniprot.org/uniprot/I7GJI1 ^@ Similarity ^@ Belongs to the DPCD family. http://togogenome.org/gene/9541:PLPP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9541:CRYZ ^@ http://purl.uniprot.org/uniprot/A0A2K5UDS8 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9541:MDH1 ^@ http://purl.uniprot.org/uniprot/I7GHA1 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family.|||Homodimer. http://togogenome.org/gene/9541:PCMT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TK85|||http://purl.uniprot.org/uniprot/I7G7X4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9541:FAM171B ^@ http://purl.uniprot.org/uniprot/A0A2K5VT30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM171 family.|||Membrane http://togogenome.org/gene/9541:LIPK ^@ http://purl.uniprot.org/uniprot/A0A2K5VP87 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9541:DDIT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSM5|||http://purl.uniprot.org/uniprot/G7PIV4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Cytoplasm|||Heterodimer.|||Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.|||Nucleus|||Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.|||Ubiquitinated, leading to its degradation by the proteasome. http://togogenome.org/gene/9541:PPM1N ^@ http://purl.uniprot.org/uniprot/A0A2K5TLZ4 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9541:HOXA1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y696|||http://purl.uniprot.org/uniprot/G7P0P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9541:TAFAZZIN ^@ http://purl.uniprot.org/uniprot/A0A2K5UMH0|||http://purl.uniprot.org/uniprot/A0A2K5UMJ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.|||Associates with multiple protein complexes.|||Belongs to the taffazin family.|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:ABCC1 ^@ http://purl.uniprot.org/uniprot/Q864R9 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane|||MK 571 inhibits sphingosine 1-phosphate and leukotriene C4 export.|||Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:12657726). Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (By similarity). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity). http://togogenome.org/gene/9541:CSTF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN07 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ELP5 ^@ http://purl.uniprot.org/uniprot/Q4R2Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP5 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:PLK1 ^@ http://purl.uniprot.org/uniprot/Q4R7Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.|||Midbody|||Nucleus|||centrosome http://togogenome.org/gene/9541:DENND6B ^@ http://purl.uniprot.org/uniprot/A0A2K5X5V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND6 family.|||Endosome|||Recycling endosome http://togogenome.org/gene/9541:CCL19 ^@ http://purl.uniprot.org/uniprot/C0ISS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:KCNK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJU3|||http://purl.uniprot.org/uniprot/A0A2K5TJU7|||http://purl.uniprot.org/uniprot/A0A8J8YP25|||http://purl.uniprot.org/uniprot/G7NTZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9541:ATP6V1H ^@ http://purl.uniprot.org/uniprot/A0A2K5V7B1|||http://purl.uniprot.org/uniprot/A0A8J8Y9P5|||http://purl.uniprot.org/uniprot/G7PBU4|||http://purl.uniprot.org/uniprot/I7G9L5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9541:TPRG1L ^@ http://purl.uniprot.org/uniprot/A0A2K5W509 ^@ Similarity ^@ Belongs to the TPRG1 family. http://togogenome.org/gene/9541:LOC102146402 ^@ http://purl.uniprot.org/uniprot/Q4R3R2 ^@ Subcellular Location Annotation ^@ acrosome http://togogenome.org/gene/9541:TFDP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZQ7|||http://purl.uniprot.org/uniprot/A0A2K5WZQ9|||http://purl.uniprot.org/uniprot/A0A2K5WZR4|||http://purl.uniprot.org/uniprot/A0A2K5WZS3|||http://purl.uniprot.org/uniprot/A0A2K5WZZ0|||http://purl.uniprot.org/uniprot/A0A7N9CWX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9541:BNIP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4J6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:FAM163A ^@ http://purl.uniprot.org/uniprot/A0A8J8YA09|||http://purl.uniprot.org/uniprot/G7NU05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/9541:CWC15 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJY0 ^@ Similarity ^@ Belongs to the CWC15 family. http://togogenome.org/gene/9541:CYP46A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEE0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:RTBDN ^@ http://purl.uniprot.org/uniprot/A0A2K5TT28|||http://purl.uniprot.org/uniprot/A0A7N9IFF7 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9541:RDH11 ^@ http://purl.uniprot.org/uniprot/G8F2I0|||http://purl.uniprot.org/uniprot/Q4JK72 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:GGPS1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XIY0|||http://purl.uniprot.org/uniprot/G7NXI9 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9541:IDH3B ^@ http://purl.uniprot.org/uniprot/A0A2K5UTS1|||http://purl.uniprot.org/uniprot/G7PGT6|||http://purl.uniprot.org/uniprot/Q28479 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion|||Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.|||The heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits can be allosterically activated by citrate (CIT) or/and ADP, and the two activators can act independently or synergistically. The heterodimer composed of IDH3A and IDH3B subunits cannot be allosterically regulated and the allosteric regulation of the heterotetramer is through the IDH3G subunit and not the IDH3B subunit. The IDH3G subunit contains the allosteric site which consists of a CIT-binding site and an ADP-binding site, and the binding of CIT and ADP causes conformational changes at the allosteric site which are transmitted to the active site in the catalytic subunit (IDH3A) through a cascade of conformational changes at the heterodimer interface, leading to stabilization of the isocitrate-binding at the active site and thus activation of the enzyme. ATP can activate the heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits at low concentrations but inhibits their activities at high concentrations, whereas ATP exhibits only inhibitory effect on the heterodimer composed of IDH3A and IDH3B subunits. http://togogenome.org/gene/9541:LOC102127506 ^@ http://purl.uniprot.org/uniprot/A0A8J8XD68|||http://purl.uniprot.org/uniprot/G7Q1V3 ^@ Similarity ^@ Belongs to the SPAN-X family. http://togogenome.org/gene/9541:ASCC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXP5 ^@ Similarity ^@ Belongs to the helicase family. http://togogenome.org/gene/9541:MAEL ^@ http://purl.uniprot.org/uniprot/G7NU39|||http://purl.uniprot.org/uniprot/Q4R786 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the maelstrom family.|||Cytoplasm|||Interacts with SMARCB1, SIN3B and DDX4. Interacts with piRNA-associated proteins TDRD1, PIWIL1 and PIWIL2 (By similarity). Interacts with TEX19 (By similarity).|||Nucleus|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity).|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage. http://togogenome.org/gene/9541:WNK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRV3|||http://purl.uniprot.org/uniprot/A0A2K5WS87 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/9541:UBE4A ^@ http://purl.uniprot.org/uniprot/A0A2K5VY40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm http://togogenome.org/gene/9541:EIF2AK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXF2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9541:IMPDH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6W4 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.|||Nucleus http://togogenome.org/gene/9541:SYS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIH8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYS1 family.|||Golgi apparatus membrane|||Interacts with ARFRP1.|||Involved in protein trafficking. May serve as a receptor for ARFRP1.|||Membrane http://togogenome.org/gene/9541:SLC25A46 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSG9|||http://purl.uniprot.org/uniprot/Q4R3T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:TOMT ^@ http://purl.uniprot.org/uniprot/A0A2K5WTM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.|||Endoplasmic reticulum http://togogenome.org/gene/9541:CT83 ^@ http://purl.uniprot.org/uniprot/Q4R717 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:PSMB2 ^@ http://purl.uniprot.org/uniprot/A0A7N9DA15|||http://purl.uniprot.org/uniprot/A0A8J8XJ00|||http://purl.uniprot.org/uniprot/G7NTH2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:STXBP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X901 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9541:CHMP2A ^@ http://purl.uniprot.org/uniprot/A0A8J8XJE1|||http://purl.uniprot.org/uniprot/G7PZC8 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9541:ZNF592 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEP3|||http://purl.uniprot.org/uniprot/G7P9C8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:ETS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYL4|||http://purl.uniprot.org/uniprot/A0A2K5TYT0|||http://purl.uniprot.org/uniprot/A0A7N9CV09|||http://purl.uniprot.org/uniprot/A0A8J8YQS4|||http://purl.uniprot.org/uniprot/G7PPN8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Cytoplasm|||Nucleus|||Transcription factor. http://togogenome.org/gene/9541:RPL36AL ^@ http://purl.uniprot.org/uniprot/A0A2K5TP61|||http://purl.uniprot.org/uniprot/G7Q2K4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9541:CTBS ^@ http://purl.uniprot.org/uniprot/Q4R8U5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. http://togogenome.org/gene/9541:NEU4 ^@ http://purl.uniprot.org/uniprot/A0A7N9D9N0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/9541:LOC102141127 ^@ http://purl.uniprot.org/uniprot/Q8MI29 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Monomer.|||NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (By similarity). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (By similarity). http://togogenome.org/gene/9541:ACVR2A ^@ http://purl.uniprot.org/uniprot/A0A7N9IF81|||http://purl.uniprot.org/uniprot/A0A8J8XY46|||http://purl.uniprot.org/uniprot/G7PKJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9541:SMIM24 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1N4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:DHCR24 ^@ http://purl.uniprot.org/uniprot/Q60HC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family.|||Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Interacts with DHCR7; this interaction regulates DHCR7 activity. http://togogenome.org/gene/9541:ARF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9541:VPS28 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKI0|||http://purl.uniprot.org/uniprot/A0A7N9CK83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS28 family.|||Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.|||Endosome membrane|||Membrane http://togogenome.org/gene/9541:PKD2L2 ^@ http://purl.uniprot.org/uniprot/Q4R933 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polycystin family.|||Membrane http://togogenome.org/gene/9541:GRIN2A ^@ http://purl.uniprot.org/uniprot/A0A2K5W5B7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9541:STX11 ^@ http://purl.uniprot.org/uniprot/A0A8J8YD53|||http://purl.uniprot.org/uniprot/G7P509 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9541:LHX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0E1|||http://purl.uniprot.org/uniprot/A0A2K5X0F0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:IRAK4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3Y9|||http://purl.uniprot.org/uniprot/A0A2K5V433 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.|||Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Cytoplasm|||Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. http://togogenome.org/gene/9541:GSS ^@ http://purl.uniprot.org/uniprot/A0A8J8XKD1|||http://purl.uniprot.org/uniprot/G7PGJ4|||http://purl.uniprot.org/uniprot/I7GA31|||http://purl.uniprot.org/uniprot/Q8HXX5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic GSH synthase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes.|||Homodimer. http://togogenome.org/gene/9541:SEMA3B ^@ http://purl.uniprot.org/uniprot/A0A2K5VF98|||http://purl.uniprot.org/uniprot/G7NXT1 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:SNAP25 ^@ http://purl.uniprot.org/uniprot/A0A2K5TV63|||http://purl.uniprot.org/uniprot/A0A7N9CTS0|||http://purl.uniprot.org/uniprot/A0A8J8YHL9|||http://purl.uniprot.org/uniprot/G7PGZ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.|||Photoreceptor inner segment|||perinuclear region|||synaptosome|||t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. http://togogenome.org/gene/9541:TIGD6 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULI2|||http://purl.uniprot.org/uniprot/G7P8N9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ENTPD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKL8|||http://purl.uniprot.org/uniprot/A0A7N9DGH8 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9541:PSPC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V444 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9541:PFN4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XVF5|||http://purl.uniprot.org/uniprot/G7PLR1 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/9541:ACVR1B ^@ http://purl.uniprot.org/uniprot/A0A2K5UYX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9541:PRICKLE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIZ2 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9541:MANBA ^@ http://purl.uniprot.org/uniprot/A0A2K5U686 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 2 family.|||Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.|||Lysosome|||Monomer. http://togogenome.org/gene/9541:LOC102135688 ^@ http://purl.uniprot.org/uniprot/A0A2K5UM27 ^@ Function|||Subcellular Location Annotation ^@ Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.|||Secreted http://togogenome.org/gene/9541:RANGRF ^@ http://purl.uniprot.org/uniprot/A0A2K5VH47|||http://purl.uniprot.org/uniprot/A0A2K5VHA4 ^@ Similarity ^@ Belongs to the MOG1 family. http://togogenome.org/gene/9541:NDC80 ^@ http://purl.uniprot.org/uniprot/Q4R630 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated at Lys-53 and Lys-59 by KAT5 during mitosis, promoting robust kinetochore-microtubule attachment. Deacetylated by SIRT1.|||Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end. Interacts with NEK2 and ZWINT specifically during mitosis. Interacts with CENPH and MIS12. May interact with AURKB, PSMC2, PSMC5 and SMC1A. May interact with RB1 during G2 phase and mitosis. Interacts with CKAP5 (By similarity). Interacts with CDT1; leading to kinetochore localization of CDT1 (By similarity).|||Nucleus|||Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. Also phosphorylated by AURKA and AURKB.|||kinetochore http://togogenome.org/gene/9541:PXN ^@ http://purl.uniprot.org/uniprot/A0A2K5UWD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paxillin family.|||cell cortex|||cytoskeleton|||focal adhesion http://togogenome.org/gene/9541:JRKL ^@ http://purl.uniprot.org/uniprot/A0A8J8XV97|||http://purl.uniprot.org/uniprot/G7PNI8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:VPS16 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS16 family.|||Early endosome|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.|||Vesicle http://togogenome.org/gene/9541:NUP107 ^@ http://purl.uniprot.org/uniprot/A0A2K5V237|||http://purl.uniprot.org/uniprot/A0A2K5V297 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup84/Nup107 family.|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||Part of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9541:IMPG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0I2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||interphotoreceptor matrix http://togogenome.org/gene/9541:NIPA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1N2|||http://purl.uniprot.org/uniprot/A0A8J8XR58|||http://purl.uniprot.org/uniprot/G7PAF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9541:CHRDL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXR9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:LOC102122521 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2C7|||http://purl.uniprot.org/uniprot/G7PWD9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. http://togogenome.org/gene/9541:SPEN ^@ http://purl.uniprot.org/uniprot/A0A2K5VXA6 ^@ Similarity ^@ Belongs to the RRM Spen family. http://togogenome.org/gene/9541:SEPTIN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3R5|||http://purl.uniprot.org/uniprot/G7PFP4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cytoplasm|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9541:FAM118A ^@ http://purl.uniprot.org/uniprot/A0A2K5V3F1|||http://purl.uniprot.org/uniprot/A0A7N9CQ53|||http://purl.uniprot.org/uniprot/G7PFX9 ^@ Similarity ^@ Belongs to the FAM118 family. http://togogenome.org/gene/9541:GPR179 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CASKIN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4M8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:SLC29A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3A9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/9541:PRDX2 ^@ http://purl.uniprot.org/uniprot/I7G9L9 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9541:LOC102141103 ^@ http://purl.uniprot.org/uniprot/A0A2K5WH18 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family.|||Monomer. http://togogenome.org/gene/9541:TLR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN04|||http://purl.uniprot.org/uniprot/B3Y610 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane|||Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. http://togogenome.org/gene/9541:LBR ^@ http://purl.uniprot.org/uniprot/A0A2K5TKM6|||http://purl.uniprot.org/uniprot/A0A8J8XAI0|||http://purl.uniprot.org/uniprot/G7NTV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9541:CEP162 ^@ http://purl.uniprot.org/uniprot/A0A2K5UW89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP162 family.|||centriole http://togogenome.org/gene/9541:SMARCAL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.|||Nucleus http://togogenome.org/gene/9541:ABI3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V191 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/9541:TMEM200B ^@ http://purl.uniprot.org/uniprot/A0A2K5WNS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/9541:SFT2D1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XND2|||http://purl.uniprot.org/uniprot/G7P487 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/9541:CDK11B ^@ http://purl.uniprot.org/uniprot/A0A2K5VNP7|||http://purl.uniprot.org/uniprot/A0A2K5VNV4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/9541:LOC102129802 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAD7 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/9541:POLR2I ^@ http://purl.uniprot.org/uniprot/A0A8J8XYY8|||http://purl.uniprot.org/uniprot/G7PXC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/9541:CNOT10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWX6|||http://purl.uniprot.org/uniprot/A0A2K5WX48|||http://purl.uniprot.org/uniprot/A0A8J8XNM0|||http://purl.uniprot.org/uniprot/G7NYB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT10 family.|||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:BEX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X340|||http://purl.uniprot.org/uniprot/G7Q3C0 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9541:IL11 ^@ http://purl.uniprot.org/uniprot/P20808 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-6 superfamily.|||Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'.|||Interacts with IL11RA to associate with IL6ST, giving rise to a multimeric signaling complex.|||Secreted http://togogenome.org/gene/9541:TRIM10 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSQ5|||http://purl.uniprot.org/uniprot/A0A2K5TSS0 ^@ Similarity|||Subunit ^@ Belongs to the TRIM/RBCC family.|||Interacts with IFNAR1; this interaction prevents association of IFNAR1 with TYK2. http://togogenome.org/gene/9541:TSPAN19 ^@ http://purl.uniprot.org/uniprot/A0A2K5WP42 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:DPEP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8R4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:BCAN ^@ http://purl.uniprot.org/uniprot/A0A2K5UB17 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aggrecan/versican proteoglycan family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:TEAD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9V8|||http://purl.uniprot.org/uniprot/A0A2K5V9X5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102133844 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CIAO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXP0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat CIA1 family.|||Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. http://togogenome.org/gene/9541:ZKSCAN1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CR92 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:IWS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHB8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TRAFD1 ^@ http://purl.uniprot.org/uniprot/Q4R970 ^@ Function|||Subunit ^@ Interacts with MAVS, TICAM1, TRAF1, TRAF2, TRAF3 and TRAF6.|||Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). http://togogenome.org/gene/9541:FMO5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WER3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9541:FAM114A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TU56 ^@ Similarity ^@ Belongs to the FAM114 family. http://togogenome.org/gene/9541:WNT8B ^@ http://purl.uniprot.org/uniprot/A0A2K5V9D2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:WASF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UD70|||http://purl.uniprot.org/uniprot/A0A8J8YIG2|||http://purl.uniprot.org/uniprot/G7PVW3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9541:NBL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/9541:HSPA1A ^@ http://purl.uniprot.org/uniprot/G8F3W4|||http://purl.uniprot.org/uniprot/I7GHC1 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9541:MRPL30 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVD7|||http://purl.uniprot.org/uniprot/Q4R6U7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.|||Mitochondrion http://togogenome.org/gene/9541:ALOX12 ^@ http://purl.uniprot.org/uniprot/A0A2K5X446 ^@ Caution|||Similarity ^@ Belongs to the lipoxygenase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:CMPK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VB30 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/9541:PIWIL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1I1|||http://purl.uniprot.org/uniprot/A0A2K5W1Q3|||http://purl.uniprot.org/uniprot/A0A7N9CKW3|||http://purl.uniprot.org/uniprot/G8F4S6 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/9541:PARP14 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKP7 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9541:MPV17L ^@ http://purl.uniprot.org/uniprot/A0A2K5WL30|||http://purl.uniprot.org/uniprot/A0A2K5WL49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/9541:LYPD6B ^@ http://purl.uniprot.org/uniprot/Q95JN7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:WASF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8K7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9541:LOC102118091 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJK7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:STYXL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCP1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9541:GFOD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQL2|||http://purl.uniprot.org/uniprot/G7Q1E5 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/9541:KRT84 ^@ http://purl.uniprot.org/uniprot/A0A2K5WH90 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:SCN11A ^@ http://purl.uniprot.org/uniprot/A0A2K5WUZ0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9541:CDK4 ^@ http://purl.uniprot.org/uniprot/I7GNS2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:PDE3A ^@ http://purl.uniprot.org/uniprot/A0A2K5VAH0 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:TMEM63C ^@ http://purl.uniprot.org/uniprot/A0A2K5WA11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/9541:ATG16L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQA7|||http://purl.uniprot.org/uniprot/A0A2K5TQB6|||http://purl.uniprot.org/uniprot/A0A2K5TQC2 ^@ Similarity ^@ Belongs to the WD repeat ATG16 family. http://togogenome.org/gene/9541:TRIM50 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQX6|||http://purl.uniprot.org/uniprot/A0A8J8Y414 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Nucleus http://togogenome.org/gene/9541:POMGNT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKR7|||http://purl.uniprot.org/uniprot/A0A2K5TKS6|||http://purl.uniprot.org/uniprot/A0A2K5TKS7|||http://purl.uniprot.org/uniprot/A0A7N9CN01|||http://purl.uniprot.org/uniprot/G7NV04 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.|||Membrane|||Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.|||The cofactor is mostly bound to the substrate.|||The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.|||The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein. http://togogenome.org/gene/9541:GALNTL5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQ06|||http://purl.uniprot.org/uniprot/Q95JX4 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Expressed in testis.|||In contrast to other members of the family, lacks the C-terminal ricin B-type lectin domain, which contributes to the glycopeptide specificity. The precise function of the enzyme is therefore unsure.|||Late endosome membrane|||Membrane|||Probable inactive glycosyltransferase required during spermatid development. May participate in protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region (By similarity).|||There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. http://togogenome.org/gene/9541:TPR ^@ http://purl.uniprot.org/uniprot/A0A2K5V4Q4 ^@ Similarity ^@ Belongs to the TPR family. http://togogenome.org/gene/9541:EGF ^@ http://purl.uniprot.org/uniprot/A0A2K5WBP9 ^@ Caution|||Function|||Subunit ^@ EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.|||Interacts with EGFR and promotes EGFR dimerization.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PSMB3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XRQ2|||http://purl.uniprot.org/uniprot/G7PUK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:TUBA3E ^@ http://purl.uniprot.org/uniprot/Q4R4C4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/9541:CLTA ^@ http://purl.uniprot.org/uniprot/A0A2K5VSX1|||http://purl.uniprot.org/uniprot/A0A2K5VSX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/9541:SNX14 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFT4|||http://purl.uniprot.org/uniprot/A0A2K5UFU6|||http://purl.uniprot.org/uniprot/A0A2K5UFY4 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9541:CHRND ^@ http://purl.uniprot.org/uniprot/A0A2K5V3B3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:EEF1A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VW69 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. http://togogenome.org/gene/9541:GRIA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLX4|||http://purl.uniprot.org/uniprot/A0A2K5TLY7|||http://purl.uniprot.org/uniprot/Q38PU7 ^@ Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.|||Cell membrane|||Endoplasmic reticulum membrane|||Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with ATAD1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts binding to ATAD1 and to GRIP1 and leads to AMPAR complex disassembly. Interacts with PRKCABP and GRIP2 (By similarity). Interacts with PICK1 (via PDZ domain) (By similarity). Interacts with GRIA1 and SYNDIG1 (By similarity). Interacts with LRFN1 (By similarity). Found in a complex with GRIA1, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5. Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (By similarity). Interacts with OLFM2 (By similarity). Interacts with AP4B1, AP4E1 and AP4M1; probably indirect it mediates the somatodendritic localization of GRIA2 in neurons (By similarity). Forms a complex with NSG1, GRIP1 and STX12; controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). Interacts with IQSEC1; the interaction is required for ARF6 activation (By similarity).|||Membrane|||Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).|||Phosphorylation at Tyr-876 is required forc interaction with IQSEC1 and ARF6 activation.|||Postsynaptic cell membrane|||Postsynaptic density membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).|||Synaptic cell membrane|||The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.|||The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate (By similarity).|||Ubiquitinated by RNF167, leading to its degradation. http://togogenome.org/gene/9541:ARG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUD1 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9541:GPRC5A ^@ http://purl.uniprot.org/uniprot/A0A2K5V8R6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:FICD ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0R5|||http://purl.uniprot.org/uniprot/G7PI52 ^@ Similarity ^@ Belongs to the fic family. http://togogenome.org/gene/9541:HYOU1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVL3|||http://purl.uniprot.org/uniprot/G7PP46 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9541:CLPTM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLPTM1 family.|||Membrane http://togogenome.org/gene/9541:NDUFB9 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8B2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:INHA ^@ http://purl.uniprot.org/uniprot/A0A2K5U0P0|||http://purl.uniprot.org/uniprot/G7PK56 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.|||Secreted http://togogenome.org/gene/9541:KRT39 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6W8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:HTR7 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CAMK2G ^@ http://purl.uniprot.org/uniprot/A0A2K5UV06|||http://purl.uniprot.org/uniprot/A0A2K5UV14|||http://purl.uniprot.org/uniprot/A0A2K5UV18|||http://purl.uniprot.org/uniprot/A0A2K5UV98|||http://purl.uniprot.org/uniprot/A0A2K5UVA9|||http://purl.uniprot.org/uniprot/I7GJL2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9541:TXN ^@ http://purl.uniprot.org/uniprot/A0A7N9CH45 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/9541:DPEP3 ^@ http://purl.uniprot.org/uniprot/Q4R7M2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.|||Homodimer; disulfide-linked (By similarity). Interacts with TEX101; co-localized on the cell surface of spermatocytes, spermatids, and testicular spermatozoa, co-localized only in cytoplasmic droplets of caput and corpus epididymal sperm (By similarity).|||Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine, leukotriene D4 and the beta-lactam antibiotic imipenem (By similarity). The absence of activity may be due to the inability of asparagine (instead of aspartate found in DPEP1/2) at position 359 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide (By similarity). A tyrosine (instead of histidine) at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance (By similarity).|||Membrane http://togogenome.org/gene/9541:NAMPT ^@ http://purl.uniprot.org/uniprot/A0A2K5ULM8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAPRTase family.|||Cytoplasm|||Homodimer.|||Nucleus|||Secreted http://togogenome.org/gene/9541:ITGB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Membrane http://togogenome.org/gene/9541:NAB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7H0|||http://purl.uniprot.org/uniprot/A0A2K5U7I8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAB family.|||Homomultimers may associate with EGR1 bound to DNA.|||Nucleus http://togogenome.org/gene/9541:BAX ^@ http://purl.uniprot.org/uniprot/A0A2K5V7Y8 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9541:CMKLR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UG47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:MYLK ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ52 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. http://togogenome.org/gene/9541:GNRHR ^@ http://purl.uniprot.org/uniprot/A0A2K5WH82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:GIPC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0Z3|||http://purl.uniprot.org/uniprot/G7PZL8 ^@ Similarity ^@ Belongs to the GIPC family. http://togogenome.org/gene/9541:VTI1B ^@ http://purl.uniprot.org/uniprot/I7GDL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/9541:MITF ^@ http://purl.uniprot.org/uniprot/A0A2K5WMF9|||http://purl.uniprot.org/uniprot/G7NZ88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9541:CD68 ^@ http://purl.uniprot.org/uniprot/A0A8J8XNB1|||http://purl.uniprot.org/uniprot/G7PTI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lysosome membrane http://togogenome.org/gene/9541:GPR156 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:DEFB125 ^@ http://purl.uniprot.org/uniprot/A4H241|||http://purl.uniprot.org/uniprot/G7PGQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:HDHD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFD7|||http://purl.uniprot.org/uniprot/A0A7N9IF34 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9541:MERTK ^@ http://purl.uniprot.org/uniprot/A0A2K5V1H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Membrane http://togogenome.org/gene/9541:RALB ^@ http://purl.uniprot.org/uniprot/Q4R379 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).|||Belongs to the small GTPase superfamily. Ras family.|||Cell membrane|||Interacts with EXOC2/Sec5 and EXOC8/Exo84. Interacts (via effector domain) with RALBP1.|||Midbody|||Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (By similarity). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (By similarity). Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (By similarity).|||Prenylation is essential for membrane localization.|||The farnesylated form confers resistance to the proapoptotic and anti-anchorage-dependent growth effects of some geranylgeranyltransferase I inhibitors. http://togogenome.org/gene/9541:EYA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VT84|||http://purl.uniprot.org/uniprot/A0A2K5VTC8|||http://purl.uniprot.org/uniprot/A0A2K5VTE3|||http://purl.uniprot.org/uniprot/A0A8J8YLN9|||http://purl.uniprot.org/uniprot/G7NWV3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9541:LTBR ^@ http://purl.uniprot.org/uniprot/A0A2K5VGQ6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ADAMTS19 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGR3 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:RSPO2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y480|||http://purl.uniprot.org/uniprot/G7PCH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the R-spondin family.|||Secreted http://togogenome.org/gene/9541:LOC102140817 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULX5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:EOMES ^@ http://purl.uniprot.org/uniprot/A0A2K5TX18 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:CUL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2Z2|||http://purl.uniprot.org/uniprot/A0A2K5W2Z9|||http://purl.uniprot.org/uniprot/G7PK72 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9541:DESI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHF5|||http://purl.uniprot.org/uniprot/A0A7N9D5H3 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/9541:SKAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5C8|||http://purl.uniprot.org/uniprot/G7P0P4 ^@ Similarity ^@ Belongs to the SKAP family. http://togogenome.org/gene/9541:KCNIP4 ^@ http://purl.uniprot.org/uniprot/Q8HYN7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the recoverin family.|||Cell membrane|||Component of heteromultimeric potassium channels (By similarity). Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity). Interacts with KCND2 (By similarity). Interacts with KCND3 (By similarity). Interacts with the C-terminus of PSEN2 and probably PSEN1 (By similarity).|||Cytoplasm|||Peroxisome|||Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.|||The KIS (K-channel inactivation suppressor) domain is required for converting A-type Kv4 current to a slowly inactivating delayed rectifier potassium current. http://togogenome.org/gene/9541:EIF4E1B ^@ http://purl.uniprot.org/uniprot/A0A2K5UXH0 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9541:GPD1L ^@ http://purl.uniprot.org/uniprot/A0A2K5V4P5|||http://purl.uniprot.org/uniprot/A0A8J8XJW7 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/9541:LOC102136643 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ASXL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Asx family.|||Nucleus http://togogenome.org/gene/9541:G6PC1 ^@ http://purl.uniprot.org/uniprot/A0A7N9IAD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:MKX ^@ http://purl.uniprot.org/uniprot/A0A7N9IFI3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SMO ^@ http://purl.uniprot.org/uniprot/A0A2K5VTF4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:ATP10D ^@ http://purl.uniprot.org/uniprot/A0A2K5V4B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9541:BRMS1L ^@ http://purl.uniprot.org/uniprot/A0A2K5WK40 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:HDAC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V841 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. http://togogenome.org/gene/9541:UBA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8P9 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9541:LOC102123657 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9541:DPPA5 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQ00|||http://purl.uniprot.org/uniprot/G7P3F8 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9541:LOC102140281 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVK2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aldolase class II family. Adducin subfamily.|||Belongs to the aldolase class II family. MtnB subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.|||Cytoplasm|||Homotetramer. Interacts with APAF1. May interact with CASP1. http://togogenome.org/gene/9541:TGFBI ^@ http://purl.uniprot.org/uniprot/A0A2K5X4B3|||http://purl.uniprot.org/uniprot/A0A7N9CID1 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9541:ANHX ^@ http://purl.uniprot.org/uniprot/A0A7N9CDR5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ABHD2 ^@ http://purl.uniprot.org/uniprot/G7P9E4|||http://purl.uniprot.org/uniprot/Q4R2Y9 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Acylglycerol lipase activity is activated upon binding to progesterone.|||Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.|||Cell membrane|||Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (By similarity). May also play a role in smooth muscle cells migration (By similarity). http://togogenome.org/gene/9541:BACE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWX5|||http://purl.uniprot.org/uniprot/A0A8J8YG33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Membrane|||Membrane raft|||Recycling endosome|||Secreted|||trans-Golgi network http://togogenome.org/gene/9541:LOC102139510 ^@ http://purl.uniprot.org/uniprot/A0A158SIQ0|||http://purl.uniprot.org/uniprot/Q8SPI5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIII family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:CALHM5 ^@ http://purl.uniprot.org/uniprot/A0A7N9CK87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9541:UTS2R ^@ http://purl.uniprot.org/uniprot/A0A2K5UGD1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.|||Membrane http://togogenome.org/gene/9541:NDUFS5 ^@ http://purl.uniprot.org/uniprot/Q4R3M6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS5 subunit family.|||Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9541:PLCZ1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U976|||http://purl.uniprot.org/uniprot/Q95JS1 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Interacts via its C2 domain with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro.|||Nucleus|||The EF-hand and C2 domains are essential for triggering Ca(2+) oscillating activity and the regulation of PLCZ1 enzyme activity.|||The X-Y linker region between PI-PLC X-box and Y-box domains may be a target for proteolysis and may play an important regulatory role during fertilization.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.|||perinuclear region http://togogenome.org/gene/9541:MMP7 ^@ http://purl.uniprot.org/uniprot/A0A8J8XW62|||http://purl.uniprot.org/uniprot/G7PNJ9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Binds 2 calcium ions per subunit. http://togogenome.org/gene/9541:TAPT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAPT1 family.|||Membrane http://togogenome.org/gene/9541:GTDC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V379|||http://purl.uniprot.org/uniprot/A0A2K5V381|||http://purl.uniprot.org/uniprot/A0A7N9CGC9|||http://purl.uniprot.org/uniprot/G7PKJ2 ^@ Similarity ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. http://togogenome.org/gene/9541:SSBP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU13|||http://purl.uniprot.org/uniprot/A0A2K5UU19|||http://purl.uniprot.org/uniprot/A0A7N9CAU5|||http://purl.uniprot.org/uniprot/A0A7N9CM22 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:EXOC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZS8|||http://purl.uniprot.org/uniprot/A0A2K5WZT6|||http://purl.uniprot.org/uniprot/A0A2K5X0E3|||http://purl.uniprot.org/uniprot/A0A7N9CER2 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/9541:GMPR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5USU0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/9541:CXCL13 ^@ http://purl.uniprot.org/uniprot/H6WS58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9541:SH3GL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLY9|||http://purl.uniprot.org/uniprot/I7G2Z3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Early endosome membrane|||Endosome membrane|||Implicated in endocytosis. May recruit other proteins to membranes with high curvature.|||Membrane http://togogenome.org/gene/9541:SMAD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIT6|||http://purl.uniprot.org/uniprot/G7P6D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:ELP6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1A6 ^@ Similarity ^@ Belongs to the ELP6 family. http://togogenome.org/gene/9541:ST3GAL6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:CCN4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJS4|||http://purl.uniprot.org/uniprot/G7PD02 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:TUSC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4U9|||http://purl.uniprot.org/uniprot/I7GHM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:DSTN ^@ http://purl.uniprot.org/uniprot/A0A2K5U939 ^@ Function|||Similarity ^@ Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.|||Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/9541:LMNTD1 ^@ http://purl.uniprot.org/uniprot/Q4R899 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:LOC102137176 ^@ http://purl.uniprot.org/uniprot/A0A2K5VP36 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9541:ORC4 ^@ http://purl.uniprot.org/uniprot/A0A7N9CQ05|||http://purl.uniprot.org/uniprot/A0A8J8XCG5|||http://purl.uniprot.org/uniprot/G7PKJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC4 family.|||Component of the origin recognition complex (ORC) that binds origins of replication.|||Nucleus http://togogenome.org/gene/9541:PFDN5 ^@ http://purl.uniprot.org/uniprot/G7PHU6 ^@ Similarity ^@ Belongs to the prefoldin subunit alpha family. http://togogenome.org/gene/9541:LXN ^@ http://purl.uniprot.org/uniprot/A0A2K5WLX9 ^@ Similarity ^@ Belongs to the protease inhibitor I47 (latexin) family. http://togogenome.org/gene/9541:LOC102127018 ^@ http://purl.uniprot.org/uniprot/A0A8J8YF72|||http://purl.uniprot.org/uniprot/G7P653 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9541:BCL2L14 ^@ http://purl.uniprot.org/uniprot/Q4R843 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9541:MPV17 ^@ http://purl.uniprot.org/uniprot/A0A2K5W873|||http://purl.uniprot.org/uniprot/G7PLV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/9541:KRT71 ^@ http://purl.uniprot.org/uniprot/A0A2K5V945 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:HVCN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVC4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hydrogen channel family.|||Homodimer.|||Membrane http://togogenome.org/gene/9541:AMIGO2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XCC5|||http://purl.uniprot.org/uniprot/G7PHN7 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. AMIGO family. http://togogenome.org/gene/9541:RBX1 ^@ http://purl.uniprot.org/uniprot/Q2PFW7 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/9541:EPN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRE9|||http://purl.uniprot.org/uniprot/A0A2K5WRF8 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/9541:DGKG ^@ http://purl.uniprot.org/uniprot/A0A2K5VZE7|||http://purl.uniprot.org/uniprot/A0A2K5VZF7|||http://purl.uniprot.org/uniprot/A0A2K5VZG5 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9541:NPEPPS ^@ http://purl.uniprot.org/uniprot/A0A2K5WAU9|||http://purl.uniprot.org/uniprot/A0A2K5WAW0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9541:KIFC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3M7|||http://purl.uniprot.org/uniprot/A0A2K5U3N4|||http://purl.uniprot.org/uniprot/A0A2K5U3P8|||http://purl.uniprot.org/uniprot/A0A2K5U3Q0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:SPECC1L ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ70|||http://purl.uniprot.org/uniprot/A0A7N9IEY9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytospin-A family.|||Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.|||May interact with both microtubules and actin cytoskeleton.|||cytoskeleton|||gap junction|||spindle http://togogenome.org/gene/9541:GFM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.|||Mitochondrion http://togogenome.org/gene/9541:EIF3J ^@ http://purl.uniprot.org/uniprot/A0A2K5UTF1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit J family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.|||Cytoplasm|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation. http://togogenome.org/gene/9541:S100A9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRV3 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9541:LZTFL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WC78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LZTFL1 family.|||Cytoplasm|||Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.|||Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking. http://togogenome.org/gene/9541:MAN1A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WX40 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9541:NEK7 ^@ http://purl.uniprot.org/uniprot/A0A8J8YPW1|||http://purl.uniprot.org/uniprot/G7NWH7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:NLRP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDX6 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/9541:PSME1 ^@ http://purl.uniprot.org/uniprot/P58238 ^@ Function|||Induction|||Similarity|||Subunit ^@ Belongs to the PA28 family.|||By interferon gamma.|||Heterodimer of PSME1 and PSME2, which forms a hexameric ring. PSME1 can form homoheptamers (By similarity).|||Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity). http://togogenome.org/gene/9541:NFASC ^@ http://purl.uniprot.org/uniprot/A0A2K5VE22|||http://purl.uniprot.org/uniprot/A0A2K5VE36|||http://purl.uniprot.org/uniprot/A0A2K5VEA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.|||Membrane http://togogenome.org/gene/9541:PLAT ^@ http://purl.uniprot.org/uniprot/A0A2K5VX93 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:B3GNT2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YEF2|||http://purl.uniprot.org/uniprot/G7PMA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:SLC16A11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRP5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:S100A11 ^@ http://purl.uniprot.org/uniprot/A0A7N9CR25 ^@ Function|||Similarity|||Subunit ^@ Belongs to the S-100 family.|||Facilitates the differentiation and the cornification of keratinocytes.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9541:PCNX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/9541:GLUL ^@ http://purl.uniprot.org/uniprot/A0A2K5TNL4|||http://purl.uniprot.org/uniprot/A0A7N9CVE9|||http://purl.uniprot.org/uniprot/Q4R7U3 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutamine synthetase family.|||Cell membrane|||Decamer; composed of two pentamers (By similarity). Interacts with PALMD (By similarity). Interacts with RHOJ (By similarity).|||Glutamine synthetase activity is inhibited by methionine sulfoximine (MSO).|||Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity).|||Membrane|||Microsome|||Mitochondrion|||Palmitoylated; undergoes autopalmitoylation.|||Ubiquitinated by ZNRF1.|||cytosol http://togogenome.org/gene/9541:RNF40 ^@ http://purl.uniprot.org/uniprot/A0A2K5V529|||http://purl.uniprot.org/uniprot/G7Q0Y6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.|||Nucleus http://togogenome.org/gene/9541:NSG2 ^@ http://purl.uniprot.org/uniprot/Q4R4W7 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/9541:ELOVL7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJH2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL7 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9541:LRRC8E ^@ http://purl.uniprot.org/uniprot/A0A2K5WKZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:MED12L ^@ http://purl.uniprot.org/uniprot/A0A2K5VQF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 12 family.|||Nucleus http://togogenome.org/gene/9541:SCP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYJ1|||http://purl.uniprot.org/uniprot/G7NVP8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. Thiolase family.|||Cytoplasm|||Interacts with PEX5; the interaction is essential for peroxisomal import.|||Mitochondrion|||Peroxisome http://togogenome.org/gene/9541:PMVK ^@ http://purl.uniprot.org/uniprot/A0A2K5V250 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/9541:CBY2 ^@ http://purl.uniprot.org/uniprot/Q95JK3 ^@ Similarity|||Subunit ^@ Belongs to the chibby family. SPERT subfamily.|||Homodimer. Binds to NEK1 (By similarity). http://togogenome.org/gene/9541:MEF2D ^@ http://purl.uniprot.org/uniprot/A0A2K5US28|||http://purl.uniprot.org/uniprot/A0A2K5US42|||http://purl.uniprot.org/uniprot/A0A2K5USA9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:KATNAL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.|||Cytoplasm|||Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9541:PLBD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJA1 ^@ Function|||Similarity ^@ Belongs to the phospholipase B-like family.|||Putative phospholipase. http://togogenome.org/gene/9541:LIF ^@ http://purl.uniprot.org/uniprot/A0A2K5UCA6|||http://purl.uniprot.org/uniprot/A0A2K5UCA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LIF/OSM family.|||LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.|||Secreted http://togogenome.org/gene/9541:ZEB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W193|||http://purl.uniprot.org/uniprot/A0A2K5W1B1 ^@ Similarity ^@ Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. http://togogenome.org/gene/9541:ATR ^@ http://purl.uniprot.org/uniprot/A0A2K5U8D7|||http://purl.uniprot.org/uniprot/A0A7N9D8L4 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. ATM subfamily. http://togogenome.org/gene/9541:CTC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CTC1 family.|||Nucleus|||telomere http://togogenome.org/gene/9541:BFSP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V910|||http://purl.uniprot.org/uniprot/A0A2K5V913|||http://purl.uniprot.org/uniprot/A0A2K5V926|||http://purl.uniprot.org/uniprot/Q4R307 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||cell cortex|||cytoskeleton http://togogenome.org/gene/9541:LOC102134014 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBG0|||http://purl.uniprot.org/uniprot/A0A2K5UH45 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/9541:SLC7A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5URE1|||http://purl.uniprot.org/uniprot/A0A2K5URF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CBLC ^@ http://purl.uniprot.org/uniprot/A0A2K5V7D8|||http://purl.uniprot.org/uniprot/A0A2K5V7G2|||http://purl.uniprot.org/uniprot/G7PXV0 ^@ Domain|||Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.|||The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. http://togogenome.org/gene/9541:CHD6 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6Y8 ^@ Similarity ^@ Belongs to the SNF2/RAD54 helicase family. http://togogenome.org/gene/9541:HEATR9 ^@ http://purl.uniprot.org/uniprot/Q4R744 ^@ Caution ^@ Despite its name, the presence of HEAT repeat is unsure and is not confirmed by repeat-detection programs. http://togogenome.org/gene/9541:CD55 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1U9|||http://purl.uniprot.org/uniprot/A0A2K5X1V4|||http://purl.uniprot.org/uniprot/A0A2K5X1Z0|||http://purl.uniprot.org/uniprot/A0A2K5X1Z6|||http://purl.uniprot.org/uniprot/A0A7N9CFZ4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:GUCY1B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/9541:TMSB10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWM9|||http://purl.uniprot.org/uniprot/G7P4J1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9541:SYCE1L ^@ http://purl.uniprot.org/uniprot/A0A2K5UVY6 ^@ Similarity ^@ Belongs to the SYCE family. http://togogenome.org/gene/9541:FXR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VES1 ^@ Similarity ^@ Belongs to the FMR1 family. http://togogenome.org/gene/9541:PRPF19 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3D0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PRP19 family.|||Homotetramer.|||Lipid droplet|||Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.|||nucleoplasm http://togogenome.org/gene/9541:KIF11 ^@ http://purl.uniprot.org/uniprot/A0A2K5U289 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:NRP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2N5|||http://purl.uniprot.org/uniprot/A0A2K5X335|||http://purl.uniprot.org/uniprot/G7PL91 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:TIMM8A ^@ http://purl.uniprot.org/uniprot/A0A2K5X878 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9541:ART3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMJ0|||http://purl.uniprot.org/uniprot/Q9GKV6 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9541:DSEL ^@ http://purl.uniprot.org/uniprot/A0A2K5TP95 ^@ Similarity ^@ Belongs to the dermatan-sulfate isomerase family. http://togogenome.org/gene/9541:CBL ^@ http://purl.uniprot.org/uniprot/A0A2K5X0C9 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.|||The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. http://togogenome.org/gene/9541:HSD17B12 ^@ http://purl.uniprot.org/uniprot/I7GJW2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:KIF9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ68|||http://purl.uniprot.org/uniprot/A0A8J8YN76|||http://purl.uniprot.org/uniprot/G7NXW4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:ALAD ^@ http://purl.uniprot.org/uniprot/Q4R4E5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ALAD family.|||Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.|||Homooctamer; active form. Homohexamer; low activity form. http://togogenome.org/gene/9541:NRXN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6M0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:EPGN ^@ http://purl.uniprot.org/uniprot/A0A8J8YCK1|||http://purl.uniprot.org/uniprot/G7P5K4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:MYH6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7N7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:SMIM15 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQD8|||http://purl.uniprot.org/uniprot/G7P7K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM15 family.|||Membrane http://togogenome.org/gene/9541:GRPEL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VN42|||http://purl.uniprot.org/uniprot/G7P8N0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/9541:CTLA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1Z9|||http://purl.uniprot.org/uniprot/G7PL88 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.|||Membrane http://togogenome.org/gene/9541:PPP1CA ^@ http://purl.uniprot.org/uniprot/A0A2K5TW84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||Cytoplasm|||nucleolus|||nucleoplasm http://togogenome.org/gene/9541:CTH ^@ http://purl.uniprot.org/uniprot/G7NWZ5|||http://purl.uniprot.org/uniprot/Q60HG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the trans-sulfuration enzymes family.|||Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate. Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione. Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce hydrogen sulfide (H2S). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, and two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia. Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (By similarity). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (By similarity). Can also accept homoserine as substrate (By similarity). Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (By similarity).|||Cytoplasm|||Homotetramer (By similarity). Interacts with CALM in a calcium-dependent manner (By similarity). http://togogenome.org/gene/9541:ACAA2 ^@ http://purl.uniprot.org/uniprot/I7G666 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9541:LRRC8B ^@ http://purl.uniprot.org/uniprot/A0A2K5UKE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SRPRA ^@ http://purl.uniprot.org/uniprot/A0A2K5V3D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:CAMKK2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CZ65 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:VAMP4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDD2|||http://purl.uniprot.org/uniprot/G7NVH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9541:RALY ^@ http://purl.uniprot.org/uniprot/A0A2K5V6P9|||http://purl.uniprot.org/uniprot/A0A2K5V6S2 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/9541:RGS4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7U7 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. http://togogenome.org/gene/9541:SS18 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBW7|||http://purl.uniprot.org/uniprot/A0A2K5VBX2|||http://purl.uniprot.org/uniprot/G7PWJ4|||http://purl.uniprot.org/uniprot/I7GN06 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/9541:FAM20B ^@ http://purl.uniprot.org/uniprot/A0A7N9CV74 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/9541:PGLYRP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR02 ^@ Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. http://togogenome.org/gene/9541:DENR ^@ http://purl.uniprot.org/uniprot/A0A2K5TSX6 ^@ Similarity ^@ Belongs to the DENR family. http://togogenome.org/gene/9541:SGSM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIZ4|||http://purl.uniprot.org/uniprot/A0A2K5UJ14|||http://purl.uniprot.org/uniprot/A0A2K5UJ30|||http://purl.uniprot.org/uniprot/A0A7N9C9P6 ^@ Similarity ^@ Belongs to the RUTBC family. http://togogenome.org/gene/9541:ALLC ^@ http://purl.uniprot.org/uniprot/G8F4Y6|||http://purl.uniprot.org/uniprot/Q4R964 ^@ Function|||Similarity ^@ Belongs to the allantoicase family.|||The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals. http://togogenome.org/gene/9541:FFAR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9541:VPS45 ^@ http://purl.uniprot.org/uniprot/G7NTS3 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9541:ILDR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4D8|||http://purl.uniprot.org/uniprot/A0A2K5X4I6|||http://purl.uniprot.org/uniprot/A0A8J8Y1N8|||http://purl.uniprot.org/uniprot/G7NXR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. LISCH7 family.|||Membrane|||tight junction http://togogenome.org/gene/9541:FGF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVN5|||http://purl.uniprot.org/uniprot/A0A7N9ICC4|||http://purl.uniprot.org/uniprot/A0A8J8XW05|||http://purl.uniprot.org/uniprot/G7P8J2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Cytoplasm|||Nucleus|||Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.|||Secreted|||cell cortex|||cytosol http://togogenome.org/gene/9541:LOC102146338 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBJ9|||http://purl.uniprot.org/uniprot/G7NTV6|||http://purl.uniprot.org/uniprot/G8F324 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:PIK3CB ^@ http://purl.uniprot.org/uniprot/A0A2K5U222|||http://purl.uniprot.org/uniprot/A0A8J8XJE7 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9541:GCHFR ^@ http://purl.uniprot.org/uniprot/A0A8J8YET9|||http://purl.uniprot.org/uniprot/G7PAX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GFRP family.|||Membrane|||Nucleus membrane|||cytosol http://togogenome.org/gene/9541:HADH ^@ http://purl.uniprot.org/uniprot/I7G921 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/9541:RNF8 ^@ http://purl.uniprot.org/uniprot/I7G290 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.|||Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.|||Belongs to the CHFR family.|||Belongs to the RNF8 family.|||Cytoplasm|||E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2.|||Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.|||Midbody|||Nucleus|||The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.|||telomere http://togogenome.org/gene/9541:EMC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWC4|||http://purl.uniprot.org/uniprot/G8F3B3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/9541:GABRB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1S8|||http://purl.uniprot.org/uniprot/A0A8J8YKT6|||http://purl.uniprot.org/uniprot/G7P6T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:ITPK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLX3 ^@ Similarity ^@ Belongs to the ITPK1 family. http://togogenome.org/gene/9541:MTCP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7K1 ^@ Similarity ^@ Belongs to the TCL1 family. http://togogenome.org/gene/9541:VEZT ^@ http://purl.uniprot.org/uniprot/A0A2K5X2Y1|||http://purl.uniprot.org/uniprot/A0A7N9CKC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vezatin family.|||Cell membrane|||Membrane|||Nucleus|||adherens junction http://togogenome.org/gene/9541:TMED2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLN0|||http://purl.uniprot.org/uniprot/Q4R5D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9541:GALNT12 ^@ http://purl.uniprot.org/uniprot/A0A2K5WI84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:TTC30B ^@ http://purl.uniprot.org/uniprot/A0A2K5UFS3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TTC30/dfy-1/fleer family.|||Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.|||cilium http://togogenome.org/gene/9541:AURKB ^@ http://purl.uniprot.org/uniprot/A0A2K5WL61|||http://purl.uniprot.org/uniprot/G7PTK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||centromere http://togogenome.org/gene/9541:GOSR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8P1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOSR2 family.|||Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.|||Membrane http://togogenome.org/gene/9541:RPL8 ^@ http://purl.uniprot.org/uniprot/I7GMX4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/9541:IGF2R ^@ http://purl.uniprot.org/uniprot/A0A2K5WFU4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:NR2C1 ^@ http://purl.uniprot.org/uniprot/G8F430|||http://purl.uniprot.org/uniprot/Q95K90 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family.|||Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Homodimer (By similarity). Heterodimer; binds DNA as a heterodimer with NR2C2 required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats (By similarity). Interacts with ESR1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth. Interacts with NRIP1 (via its LXXLL motifs); the interaction provides corepressor activity. Interacts with HDAC3 (via the DNA-binding domain). Interacts with HDAC4 (via the DNA-binding domain). Interacts with PIAS1; the interaction is required for sumoylation of NR2C1. Interacts with UBE2I; the interaction is required for sumoylation of NR2C1. Interacts with KAT2B; the interaction acts as a corepressor of gene expression (By similarity).|||Nucleus|||Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation (By similarity).|||PML body|||Phosphorylated on several serine and threonine residues. Phosphorylation on Thr-220, stimulated by all-trans retinoic acid (atRA) mediates PML location and sumoylation in proliferating cells which then modulates its association with effector molecules, KAT2B and NRIP1. Phosphorylation on Ser-581 by PKC is important for protein stability and function as activator of RARB (By similarity).|||Sumoylation requires both PIAS1 and UBE2I. Sumoylation appears to dissociate NR2C1 from the PML nuclear bodies. Enhances the interaction with NRIP1 but inhibits interaction with KAT2B. In proliferating cells, stimulation by all-trans retinoic acid, activation of MAPK1-mediated phosphorylation and recruitment to PML bodies with subsequent sumoylation, suppresses OCT4 expression (By similarity). http://togogenome.org/gene/9541:SLC35A4 ^@ http://purl.uniprot.org/uniprot/G7P8G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Membrane http://togogenome.org/gene/9541:DCTN6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WV70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.|||cytoskeleton http://togogenome.org/gene/9541:BCL7B ^@ http://purl.uniprot.org/uniprot/A0A2K5WN28 ^@ Similarity ^@ Belongs to the BCL7 family. http://togogenome.org/gene/9541:VAC14 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZL7|||http://purl.uniprot.org/uniprot/G7Q1L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAC14 family.|||Endosome membrane|||Microsome membrane http://togogenome.org/gene/9541:LSM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9H6|||http://purl.uniprot.org/uniprot/G8F3W6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||Nucleus http://togogenome.org/gene/9541:ZFX ^@ http://purl.uniprot.org/uniprot/A0A2K5UW34|||http://purl.uniprot.org/uniprot/A0A2K5UW70 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:DRGX ^@ http://purl.uniprot.org/uniprot/A0A2K5UVS1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PIGW ^@ http://purl.uniprot.org/uniprot/A0A2K5UBR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGW family.|||Endoplasmic reticulum membrane|||Membrane|||Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. http://togogenome.org/gene/9541:LAMA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4C3 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/9541:DTNA ^@ http://purl.uniprot.org/uniprot/A0A2K5UWT3|||http://purl.uniprot.org/uniprot/A0A2K5UX96|||http://purl.uniprot.org/uniprot/A0A2K5UXA6|||http://purl.uniprot.org/uniprot/A0A2K5UXF6|||http://purl.uniprot.org/uniprot/A0A2K5UXG7|||http://purl.uniprot.org/uniprot/A0A2K5UXH1|||http://purl.uniprot.org/uniprot/A0A2K5UXK1|||http://purl.uniprot.org/uniprot/A0A2K5UXM2|||http://purl.uniprot.org/uniprot/A0A2K5UXS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dystrophin family. Dystrobrevin subfamily.|||Cytoplasm http://togogenome.org/gene/9541:LRRFIP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V262|||http://purl.uniprot.org/uniprot/A0A2K5V269|||http://purl.uniprot.org/uniprot/A0A2K5V285|||http://purl.uniprot.org/uniprot/A0A2K5V2B7|||http://purl.uniprot.org/uniprot/A0A8J8Y1V3|||http://purl.uniprot.org/uniprot/G7NYL4 ^@ Similarity ^@ Belongs to the LRRFIP family. http://togogenome.org/gene/9541:HOXB5 ^@ http://purl.uniprot.org/uniprot/Q2PFU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9541:KATNB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFA6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat KATNB1 family.|||Cytoplasm|||Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9541:CLDND2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9541:KCNC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4K9|||http://purl.uniprot.org/uniprot/A0A2K5V4M9|||http://purl.uniprot.org/uniprot/A0A2K5V4P9|||http://purl.uniprot.org/uniprot/A0A2K5V4V6|||http://purl.uniprot.org/uniprot/A0A2K5V4W3|||http://purl.uniprot.org/uniprot/A0A7N9CRZ4|||http://purl.uniprot.org/uniprot/A0A7N9IBK4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:MINDY1 ^@ http://purl.uniprot.org/uniprot/Q4R7C0 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/9541:DUOX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VI09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.|||In the N-terminal section; belongs to the peroxidase family.|||Membrane http://togogenome.org/gene/9541:ALDOC ^@ http://purl.uniprot.org/uniprot/A0A805Q5V7|||http://purl.uniprot.org/uniprot/G7PTX4|||http://purl.uniprot.org/uniprot/Q9GKW3 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class I fructose-bisphosphate aldolase family.|||Homotetramer. Interacts with ATP6V1E1.|||In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain. http://togogenome.org/gene/9541:LOC102145378 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXA8 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/9541:SIGMAR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VK98 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ERG2 family.|||Cell junction|||Cytoplasmic vesicle|||Endoplasmic reticulum membrane|||Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.|||Homotrimer.|||Lipid droplet|||Membrane|||Nucleus envelope|||Nucleus inner membrane|||Nucleus outer membrane|||Postsynaptic density membrane|||The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.|||Vesicle http://togogenome.org/gene/9541:LOC102141219 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIS1|||http://purl.uniprot.org/uniprot/G8F2Z1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:TSPAN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:CAPZB ^@ http://purl.uniprot.org/uniprot/A0A2K5TMG9|||http://purl.uniprot.org/uniprot/A0A2K5TMI1|||http://purl.uniprot.org/uniprot/A0A2K5TMI2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the F-actin-capping protein beta subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit.|||cytoskeleton|||sarcomere http://togogenome.org/gene/9541:TMEM45B ^@ http://purl.uniprot.org/uniprot/A0A2K5W1T8|||http://purl.uniprot.org/uniprot/G7PPP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9541:MLH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UB34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||Nucleus http://togogenome.org/gene/9541:ALK ^@ http://purl.uniprot.org/uniprot/A0A2K5V4W8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. http://togogenome.org/gene/9541:PTGER4 ^@ http://purl.uniprot.org/uniprot/Q4R6E1|||http://purl.uniprot.org/uniprot/Q95J39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FEM1A.|||Membrane|||Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. http://togogenome.org/gene/9541:PLAC8L1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XRF4|||http://purl.uniprot.org/uniprot/G7P8K5 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9541:NDUFB10 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7S3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.|||Belongs to the complex I NDUFB10 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:E2F8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9541:LOC102137734 ^@ http://purl.uniprot.org/uniprot/A0A2K5V565|||http://purl.uniprot.org/uniprot/A0A8J8YNK8|||http://purl.uniprot.org/uniprot/G7Q1B2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PRKN ^@ http://purl.uniprot.org/uniprot/B8YGJ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBR family. Parkin subfamily.|||Forms an E3 ubiquitin ligase complex.|||Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.|||Mitochondrion|||cytosol http://togogenome.org/gene/9541:SLC19A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZ82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Cell membrane|||High-affinity transporter for the intake of thiamine. http://togogenome.org/gene/9541:PTPRG ^@ http://purl.uniprot.org/uniprot/A0A2K5VK93|||http://purl.uniprot.org/uniprot/A0A2K5VKI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.|||Membrane http://togogenome.org/gene/9541:RTN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7M0|||http://purl.uniprot.org/uniprot/A0A2K5W7M8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:LAMP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane http://togogenome.org/gene/9541:LOC102119400 ^@ http://purl.uniprot.org/uniprot/A0A2K5X463|||http://purl.uniprot.org/uniprot/Q95LR9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:XYLB ^@ http://purl.uniprot.org/uniprot/A0A2K5U7M5 ^@ Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. http://togogenome.org/gene/9541:ST3GAL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPF8|||http://purl.uniprot.org/uniprot/A0A2K5WPK4|||http://purl.uniprot.org/uniprot/A0A2K5WQ08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:SLC11A2 ^@ http://purl.uniprot.org/uniprot/Q4R4D6|||http://purl.uniprot.org/uniprot/Q9MZV1|||http://purl.uniprot.org/uniprot/Q9MZV2 ^@ Similarity ^@ Belongs to the NRAMP family. http://togogenome.org/gene/9541:UCP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YLM4|||http://purl.uniprot.org/uniprot/G7PN78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:LOC102133997 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAT4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:MPP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSK7 ^@ Function|||Subcellular Location Annotation ^@ Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.|||stereocilium http://togogenome.org/gene/9541:DLD ^@ http://purl.uniprot.org/uniprot/A0A2K5TZW4|||http://purl.uniprot.org/uniprot/G7P2G2|||http://purl.uniprot.org/uniprot/Q60HG3 ^@ Cofactor|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. Part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (subunits PDHA (PDHA1 or PDHA2) and PDHB, E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules (by non covalent bonds). The 2-oxoglutarate dehydrogenase complex is composed of OGDH (2-oxoglutarate dehydrogenase; E1), DLST (dihydrolipoamide succinyltransferase; E2) and DLD (dihydrolipoamide dehydrogenase; E3). It contains multiple copies of the three enzymatic components (E1, E2 and E3). In the nucleus, the 2-oxoglutarate dehydrogenase complex associates with KAT2A. Interacts with PDHX.|||Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. In monomeric form may have additional moonlighting function as serine protease (By similarity). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity).|||Mitochondrion matrix|||Nucleus|||The active site is a redox-active disulfide bond.|||Tyrosine phosphorylated.|||acrosome|||flagellum http://togogenome.org/gene/9541:SPRTN ^@ http://purl.uniprot.org/uniprot/A0A2K5U0J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Spartan family.|||Chromosome|||Nucleus http://togogenome.org/gene/9541:AREL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U585 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:CDKAL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9T0|||http://purl.uniprot.org/uniprot/G7P4I6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:RIC8A ^@ http://purl.uniprot.org/uniprot/A0A2K5V8L6|||http://purl.uniprot.org/uniprot/Q4R720 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cell membrane|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity).|||Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. Interacts (via C-terminus) with RGS14; the interaction stimulates the dissociation of the complex between RGS14 and the active GTP-bound form of GNAI1 (By similarity).|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/9541:SEMA3F ^@ http://purl.uniprot.org/uniprot/A0A2K5TXU6|||http://purl.uniprot.org/uniprot/A0A2K5TXU8 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:NAT14 ^@ http://purl.uniprot.org/uniprot/Q9N0D0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the camello family.|||May act as a transcription factor regulating the expression of coproporphyrinogen oxidase by binding to a promoter regulatory element.|||Membrane|||Probable acetyltransferase. http://togogenome.org/gene/9541:LOC101867486 ^@ http://purl.uniprot.org/uniprot/A0A8J8YLZ9|||http://purl.uniprot.org/uniprot/G7P4F8 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Vesicle http://togogenome.org/gene/9541:PLOD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U252 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9541:NEMP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TV32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NEMP family.|||Nucleus inner membrane http://togogenome.org/gene/9541:FBXO46 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8U2 ^@ Function ^@ Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. http://togogenome.org/gene/9541:CA6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U933|||http://purl.uniprot.org/uniprot/A0A2K5U949 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. Its role in saliva is unknown.|||Secreted http://togogenome.org/gene/9541:STX7 ^@ http://purl.uniprot.org/uniprot/I7G8H7 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9541:HMX2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CFD7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102143828 ^@ http://purl.uniprot.org/uniprot/A0A2K5UG57 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:MRPL47 ^@ http://purl.uniprot.org/uniprot/A0A7N9DBX8|||http://purl.uniprot.org/uniprot/I7G764 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL29 family.|||Mitochondrion http://togogenome.org/gene/9541:OLFML2B ^@ http://purl.uniprot.org/uniprot/A0A2K5U6C4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:TLL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5W3 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:DOCK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7U6|||http://purl.uniprot.org/uniprot/A0A2K5X895 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9541:ILDR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0S7|||http://purl.uniprot.org/uniprot/A0A2K5U0T8|||http://purl.uniprot.org/uniprot/A0A2K5U0T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. LISCH7 family.|||Membrane|||tight junction http://togogenome.org/gene/9541:SNRPD1 ^@ http://purl.uniprot.org/uniprot/Q4R5F6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP core protein family.|||Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts (via C-terminus) with SMN1 (via Tudor domain); the interaction is direct. Interacts with GEMIN2; the interaction is direct. Interacts with SNRPD2; the interaction is direct.|||Methylated on arginine residues by PRMT5 and PRMT7; probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.|||cytosol http://togogenome.org/gene/9541:VGLL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VB36|||http://purl.uniprot.org/uniprot/G7Q1T3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs.|||Nucleus http://togogenome.org/gene/9541:LOC102130015 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFJ0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/9541:NCAN ^@ http://purl.uniprot.org/uniprot/A0A2K5VGK7 ^@ Caution|||Similarity ^@ Belongs to the aggrecan/versican proteoglycan family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:KRT34 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLV1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:TGIF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U881 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PLAC1 ^@ http://purl.uniprot.org/uniprot/G7Q1Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PLAC1 family.|||Secreted http://togogenome.org/gene/9541:PRSS16 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDF6 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/9541:SNTG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WF06|||http://purl.uniprot.org/uniprot/A0A2K5WF09|||http://purl.uniprot.org/uniprot/G7PBT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||cytoskeleton http://togogenome.org/gene/9541:CXCL8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUL7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Homodimer.|||Secreted http://togogenome.org/gene/9541:LUC7L3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UY02|||http://purl.uniprot.org/uniprot/A0A2K5UY32|||http://purl.uniprot.org/uniprot/G7PUB4 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9541:LCN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9541:CYP51A1 ^@ http://purl.uniprot.org/uniprot/G7P1U1|||http://purl.uniprot.org/uniprot/Q4R8S6 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25-dihydrolanosterol likely through sequential oxidative conversion of 14-alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).|||Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||Inhibited by azalanstat. Inhibited by azole antifungal agents ketoconazole, itraconazole and fluconazole.|||It is uncertain whether Met-1 or Met-7 is the initiator.|||Microsome membrane http://togogenome.org/gene/9541:CAMTA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYI2|||http://purl.uniprot.org/uniprot/A0A2K5UYJ8|||http://purl.uniprot.org/uniprot/A0A2K5UYL8 ^@ Similarity|||Subunit ^@ Belongs to the CAMTA family.|||May interact with calmodulin. http://togogenome.org/gene/9541:NRTN ^@ http://purl.uniprot.org/uniprot/A0A2K5WLQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/9541:TARS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHX5 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:OGDHL ^@ http://purl.uniprot.org/uniprot/A0A2K5UXS3|||http://purl.uniprot.org/uniprot/A0A2K5UXT3 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/9541:HHIPL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2J6 ^@ Similarity ^@ Belongs to the HHIP family. http://togogenome.org/gene/9541:FLVCR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZD8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:MUL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGR6|||http://purl.uniprot.org/uniprot/G7NUU4|||http://purl.uniprot.org/uniprot/Q4R7G8 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-24' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization. Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway. May also be involved in the sumoylation of the membrane fission protein DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting RIGI-dependent antiviral response (By similarity). Can mediate RIGI sumoylation and disrupt its polyubiquitination (By similarity).|||Homooligomer. Interacts with MAP3K7/TAK1. Interacts with UBC9. Interacts with and sumoylates DNM1L. Interacts with MAVS. Interacts with TP53 (via N-terminus); the interaction leads to ubiquitination and proteasomal degradation of TP53.|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||The zinc finger domain is required for E3 ligase activity.|||Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. http://togogenome.org/gene/9541:ODF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBQ3|||http://purl.uniprot.org/uniprot/G8F3R8 ^@ Function ^@ Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. http://togogenome.org/gene/9541:SPA17 ^@ http://purl.uniprot.org/uniprot/Q4R2Z5 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates. http://togogenome.org/gene/9541:LYPLA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMQ1 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/9541:YIPF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Late endosome membrane|||Membrane|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:LOC102125088 ^@ http://purl.uniprot.org/uniprot/A0A2K5UME9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/9541:SEC11C ^@ http://purl.uniprot.org/uniprot/A0A8J8YDW3|||http://purl.uniprot.org/uniprot/G7PWV4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:HOPX ^@ http://purl.uniprot.org/uniprot/I7GIM6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:INKA1 ^@ http://purl.uniprot.org/uniprot/I7GHD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INKA family.|||Nucleus http://togogenome.org/gene/9541:PTX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEN7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:IL10 ^@ http://purl.uniprot.org/uniprot/A0A8J8YH31|||http://purl.uniprot.org/uniprot/G7NVB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9541:PREPL ^@ http://purl.uniprot.org/uniprot/A0A2K5WN60 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/9541:ALKBH7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQX0 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9541:TMEM178A ^@ http://purl.uniprot.org/uniprot/A0A2K5V7K7 ^@ Similarity ^@ Belongs to the TMEM178 family. http://togogenome.org/gene/9541:LMBR1L ^@ http://purl.uniprot.org/uniprot/G7PHS1|||http://purl.uniprot.org/uniprot/Q4R7X9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LIMR family.|||Cell membrane|||Dimer (By similarity). Can also form higher oligomers (By similarity). Interacts with LCN1; this interaction mediates the endocytosis of LCN1 (By similarity). Interacts with UBAC2, FAF2, VCP, AMFR, ZNRF3, CTNNB1, LRP6, GSK3A, GSK3B, FZD6, DVL2 and RNF43 (By similarity). Interaction with LGB and SCGB1A1 is controversial (By similarity).|||Endoplasmic reticulum membrane|||Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis (By similarity). http://togogenome.org/gene/9541:SERPINA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCH9|||http://purl.uniprot.org/uniprot/G7PBD8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:FBLN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCN4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the fibulin family.|||Homomultimerizes and interacts with various extracellular matrix components.|||Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:LTA4H ^@ http://purl.uniprot.org/uniprot/A0A2K5U9C9|||http://purl.uniprot.org/uniprot/G7PJ36 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/9541:LOC102140676 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:KCNJ12 ^@ http://purl.uniprot.org/uniprot/A0A7N9D225|||http://purl.uniprot.org/uniprot/A0A8J8XCB5|||http://purl.uniprot.org/uniprot/G7PTV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TWF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||cytoskeleton http://togogenome.org/gene/9541:LOC102136972 ^@ http://purl.uniprot.org/uniprot/A0A2K5WX78|||http://purl.uniprot.org/uniprot/A0A8J8XVQ5 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||Component of the 40S ribosomal subunit. http://togogenome.org/gene/9541:GABRG3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WT79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:CA3 ^@ http://purl.uniprot.org/uniprot/I7GN11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-carbonic anhydrase family.|||Cytoplasm|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9541:ARSF ^@ http://purl.uniprot.org/uniprot/A0A2K5TQG2 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9541:LOC102140788 ^@ http://purl.uniprot.org/uniprot/G7P624|||http://purl.uniprot.org/uniprot/P61256 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Component of the large ribosomal subunit. Interacts with DHX33.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm|||Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets. http://togogenome.org/gene/9541:NSUN5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIR5 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9541:NR2F1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:LEPR ^@ http://purl.uniprot.org/uniprot/A0A2K5U8P7|||http://purl.uniprot.org/uniprot/A0A2K5U8T0 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9541:LOC107129593 ^@ http://purl.uniprot.org/uniprot/A0A8U0WQ25|||http://purl.uniprot.org/uniprot/G8F3V0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:MS4A8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TY64|||http://purl.uniprot.org/uniprot/G7PPZ8 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9541:AGK ^@ http://purl.uniprot.org/uniprot/A0A2K5WYW0|||http://purl.uniprot.org/uniprot/G7P1E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AGK family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9541:DTX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5A6|||http://purl.uniprot.org/uniprot/A0A2K5W5C1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/9541:DPYD ^@ http://purl.uniprot.org/uniprot/A0A2K5V8G2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the dihydropyrimidine dehydrogenase family.|||Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.|||Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. http://togogenome.org/gene/9541:MAF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNZ7|||http://purl.uniprot.org/uniprot/A0A8J8XHI8|||http://purl.uniprot.org/uniprot/G7PDA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAF1 family.|||Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.|||Nucleus http://togogenome.org/gene/9541:CD81 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:NFYB ^@ http://purl.uniprot.org/uniprot/A0A2K5TK75|||http://purl.uniprot.org/uniprot/A0A2K5TKA1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NFYB/HAP3 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.|||Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP. http://togogenome.org/gene/9541:CHCHD4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLP3|||http://purl.uniprot.org/uniprot/A0A8J8XW51|||http://purl.uniprot.org/uniprot/G7PIL3 ^@ Subcellular Location Annotation ^@ Mitochondrion intermembrane space http://togogenome.org/gene/9541:GPR182 ^@ http://purl.uniprot.org/uniprot/G7PIU3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:CACNA1S ^@ http://purl.uniprot.org/uniprot/A0A8J8XWF9|||http://purl.uniprot.org/uniprot/G7NWG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.|||Membrane|||Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. http://togogenome.org/gene/9541:EVPL ^@ http://purl.uniprot.org/uniprot/A0A2K5X342 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:EZH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0B8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CTDP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UY30|||http://purl.uniprot.org/uniprot/A0A2K5UY78 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||This promotes the activity of RNA polymerase II. http://togogenome.org/gene/9541:DUSP7 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0H0 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9541:KANSL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRC0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.|||Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.|||Nucleus http://togogenome.org/gene/9541:ACTR1B ^@ http://purl.uniprot.org/uniprot/A0A2K5UMH2 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:SEM1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZN6|||http://purl.uniprot.org/uniprot/G7P1B4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DSS1/SEM1 family.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.|||Nucleus http://togogenome.org/gene/9541:ADAT2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYR1|||http://purl.uniprot.org/uniprot/G7P308 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.|||Cytoplasm|||Probably participates in deamination of adenosine-34 to inosine in many tRNAs. http://togogenome.org/gene/9541:FGF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKR2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:GLYR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HIBADH-related family. NP60 subfamily.|||Chromosome http://togogenome.org/gene/9541:SLFNL1 ^@ http://purl.uniprot.org/uniprot/Q4R3B7 ^@ Similarity ^@ Belongs to the Schlafen family. Subgroup I subfamily. http://togogenome.org/gene/9541:PSMC5 ^@ http://purl.uniprot.org/uniprot/I7G7U1|||http://purl.uniprot.org/uniprot/I7GHZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm http://togogenome.org/gene/9541:DUOX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.|||In the N-terminal section; belongs to the peroxidase family.|||Membrane http://togogenome.org/gene/9541:RPTOR ^@ http://purl.uniprot.org/uniprot/A0A2K5TPP8 ^@ Similarity ^@ Belongs to the WD repeat RAPTOR family. http://togogenome.org/gene/9541:RPL26L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0P7|||http://purl.uniprot.org/uniprot/G7P6X1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Belongs to the universal ribosomal protein uL24 family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/9541:EMG1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XFU7|||http://purl.uniprot.org/uniprot/G7PJP2 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/9541:BMX ^@ http://purl.uniprot.org/uniprot/A0A2K5UVN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9541:PYCR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMQ2|||http://purl.uniprot.org/uniprot/A0A8J8YL72|||http://purl.uniprot.org/uniprot/G7PT60 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/9541:PIWIL3 ^@ http://purl.uniprot.org/uniprot/G7PHF0 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/9541:GPT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V631 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/9541:TMEM266 ^@ http://purl.uniprot.org/uniprot/Q9N0B5 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Homodimer; disulfide-linked.|||Perikaryon|||The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Transplantation of the transmembrane segment S4 into HVCN1, generates a functional voltage-activated proton channel.|||Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum. Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear. Undergoes both rapid and slow structural rearrangements in response to changes in voltage. Contains a zinc-binding site that can regulate the slow conformational transition.|||dendrite http://togogenome.org/gene/9541:PRPH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJM1|||http://purl.uniprot.org/uniprot/G7P3Y4 ^@ Similarity ^@ Belongs to the PRPH2/ROM1 family. http://togogenome.org/gene/9541:TMEM251 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM251 family.|||Membrane http://togogenome.org/gene/9541:CDK5RAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U237|||http://purl.uniprot.org/uniprot/A0A2K5U2C2 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/9541:TMEM14B ^@ http://purl.uniprot.org/uniprot/A0A2K5VR23|||http://purl.uniprot.org/uniprot/A0A2K5VR38 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9541:LOC102138425 ^@ http://purl.uniprot.org/uniprot/G8F3E6 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9541:LOC102141746 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:TMEM225B ^@ http://purl.uniprot.org/uniprot/A0A2K5VT89 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:AHCYL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMN0 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/9541:MTMR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPM1|||http://purl.uniprot.org/uniprot/A0A7N9IAS5|||http://purl.uniprot.org/uniprot/A0A8J8XPP1|||http://purl.uniprot.org/uniprot/G7PNI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9541:TACC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X191|||http://purl.uniprot.org/uniprot/A0A2K5X1C0|||http://purl.uniprot.org/uniprot/A0A2K5X1P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||centrosome http://togogenome.org/gene/9541:TRIM36 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUQ5|||http://purl.uniprot.org/uniprot/A0A7N9DBA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Nucleus|||cytoskeleton http://togogenome.org/gene/9541:CELA1 ^@ http://purl.uniprot.org/uniprot/O46644 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Acts upon elastin.|||Belongs to the peptidase S1 family. Elastase subfamily.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9541:RHBDD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHH7|||http://purl.uniprot.org/uniprot/G7PHH6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PDPR ^@ http://purl.uniprot.org/uniprot/G7Q1M1 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/9541:AMER1 ^@ http://purl.uniprot.org/uniprot/G7Q2W4 ^@ Similarity ^@ Belongs to the Amer family. http://togogenome.org/gene/9541:ADGRB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCB3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:NAA20 ^@ http://purl.uniprot.org/uniprot/Q2PFM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetyltransferase family. ARD1 subfamily.|||Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.|||Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:PIK3C2G ^@ http://purl.uniprot.org/uniprot/A0A2K5UGN7|||http://purl.uniprot.org/uniprot/A0A2K5UGT4|||http://purl.uniprot.org/uniprot/A0A2K5UGU0 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9541:RNF34 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4E9|||http://purl.uniprot.org/uniprot/A0A2K5W4G1 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:LOC102139855 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKU3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:NMBR ^@ http://purl.uniprot.org/uniprot/A0A2K5WCN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PTK2B ^@ http://purl.uniprot.org/uniprot/A0A2K5WCI3|||http://purl.uniprot.org/uniprot/A0A2K5WCJ3|||http://purl.uniprot.org/uniprot/A0A2K5WCP6|||http://purl.uniprot.org/uniprot/A0A2K5WCQ3|||http://purl.uniprot.org/uniprot/A0A8J8Y222|||http://purl.uniprot.org/uniprot/G7PCY5 ^@ Subcellular Location Annotation ^@ Cell membrane|||cell cortex|||focal adhesion http://togogenome.org/gene/9541:SDAD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WP56|||http://purl.uniprot.org/uniprot/A0A2K5WPA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDA1 family.|||Required for 60S pre-ribosomal subunits export to the cytoplasm.|||nucleolus http://togogenome.org/gene/9541:G6PD ^@ http://purl.uniprot.org/uniprot/A0A2K5VEE8|||http://purl.uniprot.org/uniprot/A0A7N9CPQ8 ^@ Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. http://togogenome.org/gene/9541:TM4SF1 ^@ http://purl.uniprot.org/uniprot/Q95LS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9541:CLDN22 ^@ http://purl.uniprot.org/uniprot/A0A2K5UF63|||http://purl.uniprot.org/uniprot/G7P6L6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:ITIH3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9541:RPS19 ^@ http://purl.uniprot.org/uniprot/Q25PV7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||Interacts with RPS19BP1.|||Required for pre-rRNA processing and maturation of 40S ribosomal subunits. http://togogenome.org/gene/9541:TNFSF15 ^@ http://purl.uniprot.org/uniprot/A0A2K5UA22|||http://purl.uniprot.org/uniprot/G7PRK8 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9541:LOC102144945 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMA0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:IGF1R ^@ http://purl.uniprot.org/uniprot/A0A2K5W796|||http://purl.uniprot.org/uniprot/G7P9I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/9541:LOC102137003 ^@ http://purl.uniprot.org/uniprot/A0A2K5TT95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex).|||Belongs to the UQCC3 family.|||Membrane|||Mitochondrion inner membrane|||Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology. http://togogenome.org/gene/9541:ELAVL1 ^@ http://purl.uniprot.org/uniprot/Q4R855 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm http://togogenome.org/gene/9541:EN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Engrailed homeobox family.|||Nucleus http://togogenome.org/gene/9541:SNX32 ^@ http://purl.uniprot.org/uniprot/A0A2K5WB75 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/9541:ITPR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYE9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the InsP3 receptor family.|||Endoplasmic reticulum membrane|||Homotetramer.|||Membrane|||Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.|||The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. http://togogenome.org/gene/9541:ADGRL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ03|||http://purl.uniprot.org/uniprot/A0A2K5TQ12|||http://purl.uniprot.org/uniprot/A0A2K5TQ63 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SF3A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0V7 ^@ Similarity ^@ Belongs to the SF3A2 family. http://togogenome.org/gene/9541:AP3M1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTF2|||http://purl.uniprot.org/uniprot/A0A8J8YQP0|||http://purl.uniprot.org/uniprot/G7PEZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. http://togogenome.org/gene/9541:CALHM1 ^@ http://purl.uniprot.org/uniprot/G7PDW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9541:ARPC5 ^@ http://purl.uniprot.org/uniprot/Q4R5N7 ^@ Function|||Similarity ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. http://togogenome.org/gene/9541:MMP26 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUI9 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9541:DHODH ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ86 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:CATSPERE ^@ http://purl.uniprot.org/uniprot/A0A2K5V8Y1 ^@ Similarity ^@ Belongs to the CATSPERD family. http://togogenome.org/gene/9541:SLC14A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7Z1|||http://purl.uniprot.org/uniprot/G7PWP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urea transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:POLL ^@ http://purl.uniprot.org/uniprot/A0A2K5VDF5|||http://purl.uniprot.org/uniprot/A0A8J8Y921|||http://purl.uniprot.org/uniprot/E5FGI8|||http://purl.uniprot.org/uniprot/Q4R380 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DNA polymerase type-X family.|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Interacts with PCNA. Interacts with PAXX; promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end-filling activity of POLL. Interacts with XRCC4; promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end-filling activity of POLL. Interacts with NHEJ1/XLF; promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end-filling activity of POLL.|||Nucleus http://togogenome.org/gene/9541:ASRGL1 ^@ http://purl.uniprot.org/uniprot/G7PPU6|||http://purl.uniprot.org/uniprot/Q4R7U8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Ntn-hydrolase family.|||Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity.|||Cytoplasm|||Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.|||Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer. http://togogenome.org/gene/9541:ZFHX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ81 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PROK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WC32|||http://purl.uniprot.org/uniprot/A0A2K5WC77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/9541:ICAM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/9541:VPS52 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRI0|||http://purl.uniprot.org/uniprot/A0A7N9D492 ^@ Similarity ^@ Belongs to the VPS52 family. http://togogenome.org/gene/9541:MAP2K4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTM3|||http://purl.uniprot.org/uniprot/I7GDS3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:RIMBP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWX6|||http://purl.uniprot.org/uniprot/A0A2K5VWY3 ^@ Similarity ^@ Belongs to the RIMBP family. http://togogenome.org/gene/9541:XRCC6 ^@ http://purl.uniprot.org/uniprot/A0A8J8YAA5|||http://purl.uniprot.org/uniprot/Q4R673|||http://purl.uniprot.org/uniprot/Q4R829 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ku70 family.|||Nucleus http://togogenome.org/gene/9541:PRDM14 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQS2|||http://purl.uniprot.org/uniprot/A0A8J8YSJ2|||http://purl.uniprot.org/uniprot/G7PC03 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TRPC7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUF7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PLCD4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTL5|||http://purl.uniprot.org/uniprot/A0A2K5UTM9|||http://purl.uniprot.org/uniprot/Q4R6L3 ^@ Cofactor|||Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds 5 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.|||Cytoplasm|||Endoplasmic reticulum|||Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation (By similarity).|||Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.|||Interacts with GRIP1 (By similarity). Interacts (via GBA motif) with guanine nucleotide-binding protein G(i) alpha subunit GNAI3 (inactive GDP-bound form); low-affinity interaction (By similarity).|||Membrane|||Nucleus|||The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes.|||The GBA (G-alpha binding and activating) motif mediates binding to the alpha subunits of guanine nucleotide-binding proteins (G proteins).|||The PDZ-binding motif mediates the interaction with GRIP1.|||The PH domain is not a critical determinant of the membrane localization. http://togogenome.org/gene/9541:KRT74 ^@ http://purl.uniprot.org/uniprot/A0A2K5UX57 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:AQP7 ^@ http://purl.uniprot.org/uniprot/Q4R691 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA).|||Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (By similarity). The channel is also permeable to urea (By similarity). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).|||Homotetramer. Interacts (via N-terminus) with PLIN1.|||Lipid droplet|||cell cortex http://togogenome.org/gene/9541:GPR180 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ87|||http://purl.uniprot.org/uniprot/G7PVL1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:DYNLRB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3W8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.|||cytoskeleton http://togogenome.org/gene/9541:IL17C ^@ http://purl.uniprot.org/uniprot/A0A2K5X1I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9541:PHC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5F6|||http://purl.uniprot.org/uniprot/A0A2K5U5L1|||http://purl.uniprot.org/uniprot/G7NZF5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TCF25 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUL5 ^@ Similarity ^@ Belongs to the TCF25 family. http://togogenome.org/gene/9541:TASP1 ^@ http://purl.uniprot.org/uniprot/I7G6M1 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/9541:NR2E1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:ENGASE ^@ http://purl.uniprot.org/uniprot/A0A2K5WE48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 85 family.|||cytosol http://togogenome.org/gene/9541:EVA1A ^@ http://purl.uniprot.org/uniprot/A0A2K5UI30|||http://purl.uniprot.org/uniprot/G7PMK7 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/9541:LOC102125186 ^@ http://purl.uniprot.org/uniprot/Q4R882 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:PDYN ^@ http://purl.uniprot.org/uniprot/A0A7N9I981 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.|||Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Leumorphin has a typical opiod activity and may have anti-apoptotic effect.|||Secreted http://togogenome.org/gene/9541:OSBPL8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKF4|||http://purl.uniprot.org/uniprot/A0A2K5TKK1|||http://purl.uniprot.org/uniprot/A0A2K5TKK3|||http://purl.uniprot.org/uniprot/A0A8J8XM37|||http://purl.uniprot.org/uniprot/G7PI36 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9541:ACTN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSR0|||http://purl.uniprot.org/uniprot/A0A2K5TSR3 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9541:IGFBP5 ^@ http://purl.uniprot.org/uniprot/G7PLE3 ^@ Caution|||Function|||Subcellular Location Annotation ^@ IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:TAF6L ^@ http://purl.uniprot.org/uniprot/A0A2K5USE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF6 family.|||Nucleus http://togogenome.org/gene/9541:GPN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7R7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.|||Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9541:CCL8 ^@ http://purl.uniprot.org/uniprot/G7PU24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:SLC25A18 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:ACE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X283 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the peptidase M2 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Membrane|||Secreted|||cilium http://togogenome.org/gene/9541:LOC107129591 ^@ http://purl.uniprot.org/uniprot/G7P2L6|||http://purl.uniprot.org/uniprot/G7P2M7|||http://purl.uniprot.org/uniprot/G7P2P0 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:BTK ^@ http://purl.uniprot.org/uniprot/A0A2K5VDZ2|||http://purl.uniprot.org/uniprot/G7Q392 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9541:LIMS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9V6|||http://purl.uniprot.org/uniprot/A0A2K5U9X0|||http://purl.uniprot.org/uniprot/I7G9V9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.|||Cell membrane|||Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.|||focal adhesion http://togogenome.org/gene/9541:ZFYVE27 ^@ http://purl.uniprot.org/uniprot/A0A2K5UY58|||http://purl.uniprot.org/uniprot/A0A2K5UY62|||http://purl.uniprot.org/uniprot/A0A2K5UY92|||http://purl.uniprot.org/uniprot/A0A2K5UYA6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Recycling endosome membrane|||growth cone membrane http://togogenome.org/gene/9541:FCHO2 ^@ http://purl.uniprot.org/uniprot/A0A2K5USL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FCHO family.|||clathrin-coated pit http://togogenome.org/gene/9541:KCND3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXA6|||http://purl.uniprot.org/uniprot/A0A8J8XCK3|||http://purl.uniprot.org/uniprot/G7NW61 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||dendrite http://togogenome.org/gene/9541:NUMB ^@ http://purl.uniprot.org/uniprot/A0A2K5WTY1|||http://purl.uniprot.org/uniprot/A0A2K5WTY3|||http://purl.uniprot.org/uniprot/A0A2K5WTZ1|||http://purl.uniprot.org/uniprot/G7PAT2 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Plays a role in the process of neurogenesis. http://togogenome.org/gene/9541:ATP13A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2G1|||http://purl.uniprot.org/uniprot/Q95JN5 ^@ Function|||Sequence Caution|||Similarity|||Subcellular Location Annotation ^@ ATP-driven pump involved in endocytosis-dependent polyamine transport. Uses ATP as an energy source to transfer polyamine precursor putrescine from the endosomal compartment to the cytosol.|||Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Contaminating sequence. Potential poly-A sequence.|||Early endosome membrane|||Late endosome membrane|||Membrane|||Recycling endosome membrane http://togogenome.org/gene/9541:SORL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVA7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS10-related sortilin family. SORL1 subfamily.|||Cell membrane|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Recycling endosome membrane|||Secreted|||multivesicular body membrane|||secretory vesicle membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:LOC102130580 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0B4 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9541:INTS14 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXJ3|||http://purl.uniprot.org/uniprot/A0A2K5UXS0|||http://purl.uniprot.org/uniprot/I7G7P7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INTS14 family.|||Nucleus|||Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. http://togogenome.org/gene/9541:PNPT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm http://togogenome.org/gene/9541:CSE1L ^@ http://purl.uniprot.org/uniprot/A0A2K5WF48|||http://purl.uniprot.org/uniprot/A0A8J8YQ05|||http://purl.uniprot.org/uniprot/G7PG22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPO2/CSE1 family.|||Cytoplasm http://togogenome.org/gene/9541:APOA5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WP26 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9541:HIBCH ^@ http://purl.uniprot.org/uniprot/A0A2K5VSZ9|||http://purl.uniprot.org/uniprot/I7G8D4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.|||Mitochondrion http://togogenome.org/gene/9541:KAT2B ^@ http://purl.uniprot.org/uniprot/G7NY79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. GCN5 subfamily.|||centrosome http://togogenome.org/gene/9541:NAP1L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUU8|||http://purl.uniprot.org/uniprot/A0A2K5TUV1|||http://purl.uniprot.org/uniprot/I7GLJ2 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9541:TRIP12 ^@ http://purl.uniprot.org/uniprot/A0A2K5W101|||http://purl.uniprot.org/uniprot/A0A2K5W1A1|||http://purl.uniprot.org/uniprot/A0A7N9CWS4|||http://purl.uniprot.org/uniprot/G7PK88 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPL family. K-HECT subfamily.|||E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.|||nucleoplasm http://togogenome.org/gene/9541:MAP1LC3B ^@ http://purl.uniprot.org/uniprot/A0A7N9C6Y1|||http://purl.uniprot.org/uniprot/Q4R530 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9541:FAM221A ^@ http://purl.uniprot.org/uniprot/A0A2K5WRE7 ^@ Similarity ^@ Belongs to the FAM221 family. http://togogenome.org/gene/9541:GNG3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XIX8|||http://purl.uniprot.org/uniprot/G7PPT4|||http://purl.uniprot.org/uniprot/I7GMQ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9541:TTC19 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHX8 ^@ Similarity ^@ Belongs to the TTC19 family. http://togogenome.org/gene/9541:AGBL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UME5|||http://purl.uniprot.org/uniprot/A0A2K5UMF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||cytosol http://togogenome.org/gene/9541:ATP12A ^@ http://purl.uniprot.org/uniprot/A0A2K5UEJ9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:SLC5A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9541:KCNA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKT9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:BRINP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YF47|||http://purl.uniprot.org/uniprot/G7PRK2 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9541:PPP3CB ^@ http://purl.uniprot.org/uniprot/I7GIS6 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/9541:RBM48 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMQ6 ^@ Similarity ^@ Belongs to the RBM48 family. http://togogenome.org/gene/9541:IDO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TU13 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/9541:IZUMO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGJ7 ^@ Similarity ^@ Belongs to the Izumo family. http://togogenome.org/gene/9541:ACTL7A ^@ http://purl.uniprot.org/uniprot/A0A2K5UD76|||http://purl.uniprot.org/uniprot/Q4R6Q3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin family.|||Cytoplasm|||Golgi apparatus|||Interacts (via N-terminus) with TES (via LIM domain 2). Heterodimer with TES; the heterodimer interacts with ENAH to form a heterotrimer. Interacts with ACTL9.|||May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.|||Nucleus|||cytoskeleton http://togogenome.org/gene/9541:SLC16A9 ^@ http://purl.uniprot.org/uniprot/A0A8J8YS42|||http://purl.uniprot.org/uniprot/G7PDF0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:DES ^@ http://purl.uniprot.org/uniprot/B3Y602 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:MARF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUD8 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9541:SLC25A19 ^@ http://purl.uniprot.org/uniprot/G7PST1|||http://purl.uniprot.org/uniprot/Q5IS35 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrial transporter mediating uptake of thiamine diphosphate into mitochondria. It is not clear if the antiporter activity is affected by the membrane potential or by the proton electrochemical gradient.|||Mitochondrion membrane|||Previously identified as the mitochondrial deoxyribonucleotide carrier. However other experiments later demonstrated that SLC25A19 is a thiamine diphosphate transporter and not a mitochondrial deoxyribonucleotide carrier. http://togogenome.org/gene/9541:ACAD8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WP11 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9541:CACNG3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLZ1|||http://purl.uniprot.org/uniprot/G7Q0R3|||http://purl.uniprot.org/uniprot/Q4R589 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.|||The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with AP4M1 and GRIA1; associates GRIA1 with the adaptor protein complex 4 (AP-4) to target GRIA1 to the somatodendritic compartment of neurons. http://togogenome.org/gene/9541:IFT43 ^@ http://purl.uniprot.org/uniprot/A0A7N9CSQ0 ^@ Similarity ^@ Belongs to the IFT43 family. http://togogenome.org/gene/9541:COPB1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XMC7|||http://purl.uniprot.org/uniprot/G7PQN7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Endoplasmic reticulum-Golgi intermediate compartment|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9541:TMPRSS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQI7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:GRAMD1B ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ93|||http://purl.uniprot.org/uniprot/A0A2K5UJJ0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:NDST3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9541:JAGN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLU3|||http://purl.uniprot.org/uniprot/G8F652 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the jagunal family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:TENT5B ^@ http://purl.uniprot.org/uniprot/A0A2K5WBP7 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9541:GNAI2 ^@ http://purl.uniprot.org/uniprot/Q4R592 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily.|||Cell membrane|||Cytoplasm|||G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. In this context, interacts with GNB2 (By similarity). Interacts with UNC5B (By similarity). Interacts with GPSM1 (By similarity). Interacts with RGS12 and RGS14 (By similarity). Interacts (inactive GDP-bound form) with NUCB1 (via GBA motif); the interaction leads to activation of GNAI3 (By similarity). Interacts (inactive GDP-bound form) with CCDC88C/DAPLE (via GBA motif) (By similarity). Interacts (inactive GDP-bound form) with CCDC8A/GIV (via GBA motif) (By similarity). Interacts with CXCR1 and CXCR2 (By similarity).|||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division (By similarity).|||Membrane|||Ubiquitously expressed. Most abundant in the lung and in the spleen.|||centrosome http://togogenome.org/gene/9541:OTUB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJQ2 ^@ Similarity ^@ Belongs to the peptidase C65 family. http://togogenome.org/gene/9541:S100A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBB8|||http://purl.uniprot.org/uniprot/A0A8J8Y4J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9541:TMEM17 ^@ http://purl.uniprot.org/uniprot/A0A7N9IHF4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SERPIND1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTW1|||http://purl.uniprot.org/uniprot/G7PHA8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:PITHD1 ^@ http://purl.uniprot.org/uniprot/I7G9N5 ^@ Similarity ^@ Belongs to the PITHD1 family. http://togogenome.org/gene/9541:LOC102115270 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INCENP family.|||Midbody|||Nucleus|||kinetochore|||spindle http://togogenome.org/gene/9541:CCN2 ^@ http://purl.uniprot.org/uniprot/I7G525 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:NDUFV3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMZ4|||http://purl.uniprot.org/uniprot/A0A2K5VN19 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.|||Belongs to the complex I NDUFV3 subunit family.|||Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. http://togogenome.org/gene/9541:LOC102116507 ^@ http://purl.uniprot.org/uniprot/A0A2K5UE54 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:WASHC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGQ0|||http://purl.uniprot.org/uniprot/G7PJB6 ^@ Similarity ^@ Belongs to the CCDC53 family. http://togogenome.org/gene/9541:OGG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0W2 ^@ Function|||Similarity ^@ Belongs to the type-1 OGG1 family.|||DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. http://togogenome.org/gene/9541:LOC102133131 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9541:LOC102122055 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUZ3|||http://purl.uniprot.org/uniprot/G7PRL7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Endoplasmic reticulum|||In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.|||Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.|||Membrane|||Mitochondrion inner membrane|||Monomer. Also occurs as a complex with tryptase in mast cells.|||Nucleus membrane|||cytosol|||extracellular matrix http://togogenome.org/gene/9541:ST6GALNAC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:NUBP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4T0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.|||Nucleus|||centrosome http://togogenome.org/gene/9541:TXNL4B ^@ http://purl.uniprot.org/uniprot/A0A7N9IA00|||http://purl.uniprot.org/uniprot/A0A8J8YJA8|||http://purl.uniprot.org/uniprot/G7Q1J2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/9541:UBE2F ^@ http://purl.uniprot.org/uniprot/A0A2K5VB43|||http://purl.uniprot.org/uniprot/A0A2K5VB62|||http://purl.uniprot.org/uniprot/A0A2K5VBA5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:TNFSF14 ^@ http://purl.uniprot.org/uniprot/E9NVF7 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9541:FGD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZX8 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:UTP15 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYR7 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9541:RRAD ^@ http://purl.uniprot.org/uniprot/A0A2K5V2G5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9541:RTN4R ^@ http://purl.uniprot.org/uniprot/Q9N0E3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nogo receptor family.|||Cell membrane|||Homodimer. Interacts with MAG (By similarity). Interacts with RTN4 (By similarity). Interacts with NGFR. Interacts with LINGO1. Interacts with KIAA0319L (By similarity). Interacts with OLFM1; this inhibits interaction with LINGO1 and NGFR (By similarity).|||Membrane raft|||N-glycosylated. O-glycosylated. Contains terminal sialic acid groups on its glycan chains.|||Perikaryon|||Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1 (By similarity). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition (By similarity). May play a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (By similarity). Interacts with OMG (By similarity).|||axon|||dendrite http://togogenome.org/gene/9541:EIF3G ^@ http://purl.uniprot.org/uniprot/A0A2K5WAN0 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit G family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation.|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.|||perinuclear region http://togogenome.org/gene/9541:BRMS1 ^@ http://purl.uniprot.org/uniprot/I7GCX1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:HEPH ^@ http://purl.uniprot.org/uniprot/A0A2K5WZ73|||http://purl.uniprot.org/uniprot/G7Q2X1 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9541:SFMBT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W642 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:EME1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQQ7 ^@ Similarity ^@ Belongs to the EME1/MMS4 family. http://togogenome.org/gene/9541:GALNT16 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:HSD17B13 ^@ http://purl.uniprot.org/uniprot/A0A8J8YIB5|||http://purl.uniprot.org/uniprot/G7P5V3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:TMEM38A ^@ http://purl.uniprot.org/uniprot/G7PZR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/9541:TNFRSF21 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIJ8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PPCS ^@ http://purl.uniprot.org/uniprot/A0A2K5TRD4 ^@ Similarity ^@ Belongs to the PPC synthetase family. http://togogenome.org/gene/9541:SSTR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNX5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).|||Membrane|||Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. http://togogenome.org/gene/9541:LOC102132378 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9541:RFX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7D6|||http://purl.uniprot.org/uniprot/A0A2K5X7G5|||http://purl.uniprot.org/uniprot/A0A2K5X7I3|||http://purl.uniprot.org/uniprot/G7PSF9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TUFM ^@ http://purl.uniprot.org/uniprot/A0A2K5W255 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/9541:LOC102126513 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TMEM9 ^@ http://purl.uniprot.org/uniprot/Q4R576 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/9541:GRID1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKB9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9541:SLC25A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:ELOVL3 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4P6|||http://purl.uniprot.org/uniprot/G7PDU3 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL3 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-Glycosylated.|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9541:LOC102142998 ^@ http://purl.uniprot.org/uniprot/A0A023JCC0 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Theta family.|||Homodimer. http://togogenome.org/gene/9541:LOC102121169 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYZ3|||http://purl.uniprot.org/uniprot/B3Y689 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response.|||Cell membrane|||Cytoplasm|||Homodimer.|||Membrane http://togogenome.org/gene/9541:GPX7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXA5 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9541:RNASEH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLI4 ^@ Function|||Similarity ^@ Belongs to the RNase H family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/9541:IL1RL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSK9 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9541:TMEM134 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPZ8|||http://purl.uniprot.org/uniprot/A0A2K5UQ38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Membrane http://togogenome.org/gene/9541:TIMP3 ^@ http://purl.uniprot.org/uniprot/P61269 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protease inhibitor I35 (TIMP) family.|||Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15 (By similarity).|||Interacts with EFEMP1.|||extracellular matrix http://togogenome.org/gene/9541:LOC101925710 ^@ http://purl.uniprot.org/uniprot/A0A8J8XMW9|||http://purl.uniprot.org/uniprot/G7NZK0 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9541:TMBIM4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9541:SCN5A ^@ http://purl.uniprot.org/uniprot/A0A2K5WYW9|||http://purl.uniprot.org/uniprot/A0A2K5WZD8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9541:SGK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2R8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:LSS ^@ http://purl.uniprot.org/uniprot/A0A2K5TLI2 ^@ Similarity ^@ Belongs to the terpene cyclase/mutase family. http://togogenome.org/gene/9541:CYP26B1 ^@ http://purl.uniprot.org/uniprot/A0A7N9IG73 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:MACIR ^@ http://purl.uniprot.org/uniprot/A0A8J8YQW5|||http://purl.uniprot.org/uniprot/G7P810 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UNC119-binding protein family.|||Cytoplasm|||cilium http://togogenome.org/gene/9541:SLC25A23 ^@ http://purl.uniprot.org/uniprot/A0A2K5X467 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:NPR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGJ2|||http://purl.uniprot.org/uniprot/A0A2K5VGJ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SLC25A14 ^@ http://purl.uniprot.org/uniprot/A0A2K5V243|||http://purl.uniprot.org/uniprot/I7GMB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:LDHB ^@ http://purl.uniprot.org/uniprot/G7PCH4|||http://purl.uniprot.org/uniprot/I7GKK2|||http://purl.uniprot.org/uniprot/Q4R5B6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDH/MDH superfamily. LDH family.|||Cytoplasm|||Homotetramer. Interacts with PTEN upstream reading frame protein MP31; the interaction leads to inhibition of mitochondrial lactate dehydrogenase activity, preventing conversion of lactate to pyruvate in mitochondria.|||Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ATP1A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CLDN6 ^@ http://purl.uniprot.org/uniprot/G7Q0B0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:BCL7C ^@ http://purl.uniprot.org/uniprot/A0A2K5V193|||http://purl.uniprot.org/uniprot/A0A2K5V1A2 ^@ Similarity ^@ Belongs to the BCL7 family. http://togogenome.org/gene/9541:FAM102B ^@ http://purl.uniprot.org/uniprot/A0A2K5X5M4|||http://purl.uniprot.org/uniprot/G8F4J1 ^@ Similarity ^@ Belongs to the FAM102 family. http://togogenome.org/gene/9541:FERMT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8F3 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/9541:SCRN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4I0 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/9541:LOC102124330 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9541:EDA2R ^@ http://purl.uniprot.org/uniprot/A0A2K5TKN6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC101866303 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZS8|||http://purl.uniprot.org/uniprot/A0A8J8XJ50|||http://purl.uniprot.org/uniprot/G7PHC8 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/9541:MRFAP1L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UET2|||http://purl.uniprot.org/uniprot/G7P578 ^@ Similarity ^@ Belongs to the MORF4 family-associated protein family. http://togogenome.org/gene/9541:SPATS2L ^@ http://purl.uniprot.org/uniprot/A0A2K5WAB6|||http://purl.uniprot.org/uniprot/A0A2K5WAB9|||http://purl.uniprot.org/uniprot/G7PL52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPATS2 family.|||Cytoplasm http://togogenome.org/gene/9541:MEIS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKT5|||http://purl.uniprot.org/uniprot/I7GEN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9541:GCM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULM4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102122997 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPS1 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family.|||Monomer. http://togogenome.org/gene/9541:EXT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXF5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Forms a homo/heterooligomeric complex with EXT2. Interacts with NDST1.|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9541:LOC102123456 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COA8 family.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ANXA7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHK9|||http://purl.uniprot.org/uniprot/Q4R5L5 ^@ Domain|||Function|||Similarity|||Subunit ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.|||Interacts with PDCD6. http://togogenome.org/gene/9541:CLDN11 ^@ http://purl.uniprot.org/uniprot/G7NZF2|||http://purl.uniprot.org/uniprot/Q4R3L1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the claudin family.|||Cell membrane|||Interacts with tetraspanin-3/TSPAN3. Interacts with OCLN.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:NEK8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSY6|||http://purl.uniprot.org/uniprot/G7PTY4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. http://togogenome.org/gene/9541:LOC102135422 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0X8|||http://purl.uniprot.org/uniprot/A0A2K5X143 ^@ Similarity ^@ Belongs to the BANP/SMAR1 family. http://togogenome.org/gene/9541:PLAGL2 ^@ http://purl.uniprot.org/uniprot/A0A7N9D9R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9541:C9 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2W7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted|||Target cell membrane http://togogenome.org/gene/9541:ACTR8 ^@ http://purl.uniprot.org/uniprot/A0A8J8YT00|||http://purl.uniprot.org/uniprot/G7NZU0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin family. ARP8 subfamily.|||Chromosome|||Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.|||Nucleus|||Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.|||Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. http://togogenome.org/gene/9541:DNALI1 ^@ http://purl.uniprot.org/uniprot/Q4R3K5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the inner dynein arm light chain family.|||Cytoplasm|||Dynein axonemal particle|||Interacts with CFAP45 (By similarity). Interacts with DYNC1H1 (By similarity).|||May play a dynamic role in flagellar motility.|||cilium|||flagellum http://togogenome.org/gene/9541:TSPAN33 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:SNX25 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIU5|||http://purl.uniprot.org/uniprot/A0A7N9CPW6|||http://purl.uniprot.org/uniprot/G7P6N5 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9541:DNM3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TS56 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9541:SF3B5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMW7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SF3B5 family.|||Component of the spliceosome B complex.|||Nucleus http://togogenome.org/gene/9541:SDHD ^@ http://purl.uniprot.org/uniprot/A0A2K5VD68|||http://purl.uniprot.org/uniprot/A0A2K5VDD8|||http://purl.uniprot.org/uniprot/A0A8J8XED5|||http://purl.uniprot.org/uniprot/G7PNT6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CybS family.|||Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/9541:LOC102136518 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2L6|||http://purl.uniprot.org/uniprot/I7G2L7 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9541:GABBR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VY83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TMEFF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDS2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:FDXR ^@ http://purl.uniprot.org/uniprot/A0A2K5VSG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferredoxin--NADP reductase type 1 family.|||Mitochondrion|||Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. http://togogenome.org/gene/9541:LOC102120794 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8L2 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9541:LOC101865459 ^@ http://purl.uniprot.org/uniprot/Q4R3A6 ^@ Caution ^@ Product of a dubious CDS prediction. May be a non-coding RNA. http://togogenome.org/gene/9541:FADS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:HSP90AB1 ^@ http://purl.uniprot.org/uniprot/Q4R4T5 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 90 family.|||Cell membrane|||Cleaved following oxidative stress resulting in HSP90AB1 protein radicals formation; disrupts the chaperoning function and the degradation of its client proteins.|||Cytoplasm|||Dynein axonemal particle|||ISGylated.|||In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state.|||Melanosome|||Methylated by SMYD2; facilitates dimerization and chaperone complex formation; promotes cancer cell proliferation.|||Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery. Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription. Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10.|||Monomer. Homodimer (By similarity). Forms a complex with CDK6 and CDC37. Interacts with UNC45A; binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer (By similarity). Interacts with CHORDC1 (By similarity). Interacts with DNAJC7. Interacts with FKBP4. May interact with NWD1. Interacts with SGTA. Interacts with HSF1 in an ATP-dependent manner. Interacts with MET; the interaction suppresses MET kinase activity. Interacts with ERBB2 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity. Interacts with HIF1A, KEAP1 and RHOBTB2. Interacts with STUB1 and SMAD3. Interacts with XPO1 and AHSA1. Interacts with BIRC2. Interacts with KCNQ4; promotes cell surface expression of KCNQ4. Interacts with BIRC2; prevents auto-ubiquitination and degradation of its client protein BIRC2. Interacts with NOS3. Interacts with AHR; interaction is inhibited by HSP90AB1 phosphorylation on Ser-226 and Ser-255. Interacts with STIP1 and CDC37; upon SMYD2-dependent methylation. Interacts with JAK2 and PRKCE; promotes functional activation in a heat shock-dependent manner. Interacts with HSP90AA1; interaction is constitutive. HSP90AB1-CDC37 chaperone complex interacts with inactive MAPK7 (via N-terminal half) in resting cells; the interaction is MAP2K5-independent and prevents from ubiquitination and proteasomal degradation. Interacts with CDC25A; prevents heat shock-mediated CDC25A degradation and contributes to cell cycle progression. Interacts with TP53 (via DNA binding domain); suppresses TP53 aggregation and prevents from irreversible thermal inactivation. Interacts with TGFB1 processed form (LAP); inhibits latent TGFB1 activation (By similarity). Interacts with TRIM8; prevents nucleus translocation of phosphorylated STAT3 and HSP90AB1 (By similarity). Interacts with NR3C1 (via domain NR LBD) and NR1D1 (via domain NR LBD) (By similarity). Interacts with PDCL3 (By similarity). Interacts with TTC4 (via TPR repeats) (By similarity). Interacts with IL1B; the interaction facilitates cargo translocation into the ERGIC (By similarity).|||Nucleus|||Phosphorylation at Tyr-301 by SRC is induced by lipopolysaccharide. Phosphorylation at Ser-226 and Ser-255 inhibits AHR interaction.|||S-nitrosylated; negatively regulates the ATPase activity.|||Secreted|||The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.|||Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro). http://togogenome.org/gene/9541:LRP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4Q3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LDLR family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:SH2B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVT4 ^@ Similarity ^@ Belongs to the SH2B adapter family. http://togogenome.org/gene/9541:POLR3D ^@ http://purl.uniprot.org/uniprot/A0A2K5UM89|||http://purl.uniprot.org/uniprot/G7PCV0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LMOD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLR2 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:GANC ^@ http://purl.uniprot.org/uniprot/A0A2K5W0E6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/9541:MIGA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYJ8|||http://purl.uniprot.org/uniprot/A0A7N9CBP6 ^@ Similarity ^@ Belongs to the mitoguardin family. http://togogenome.org/gene/9541:APOBEC3C ^@ http://purl.uniprot.org/uniprot/I7GI38 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:CSTF1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YE71|||http://purl.uniprot.org/uniprot/Q4R7X3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FABP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFN5 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:SLC25A51 ^@ http://purl.uniprot.org/uniprot/A0A7N9CMS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:LOC102131468 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMK2|||http://purl.uniprot.org/uniprot/A0A2K5TML4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.|||Nucleus http://togogenome.org/gene/9541:SEMA4G ^@ http://purl.uniprot.org/uniprot/A0A2K5WLL7 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ACVRL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9541:RPS6KA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRF6|||http://purl.uniprot.org/uniprot/A0A2K5VRH3|||http://purl.uniprot.org/uniprot/A0A7N9CBN5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9541:MRPL52 ^@ http://purl.uniprot.org/uniprot/A0A2K5X932 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL52 family.|||Mitochondrion http://togogenome.org/gene/9541:RHAG ^@ http://purl.uniprot.org/uniprot/O77484 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9541:MOSPD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4V4|||http://purl.uniprot.org/uniprot/A0A2K5X4W1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:FOXR2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CQV5|||http://purl.uniprot.org/uniprot/G8F4L6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MOS ^@ http://purl.uniprot.org/uniprot/A0A2K5UF73 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:SLC25A44 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAQ3|||http://purl.uniprot.org/uniprot/G7NV80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:GJD2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YLU2|||http://purl.uniprot.org/uniprot/G7PAP6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9541:ANXA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSU0|||http://purl.uniprot.org/uniprot/A0A8J8XPJ1|||http://purl.uniprot.org/uniprot/G7PME1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Zymogen granule membrane http://togogenome.org/gene/9541:ERCC3 ^@ http://purl.uniprot.org/uniprot/Q60HG1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.|||Belongs to the helicase family. RAD25/XPB subfamily.|||Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with PUF60. Interacts with ATF7IP. Interacts with KAT2A; leading to KAT2A recruitment to promoters and acetylation of histones.|||Nucleus http://togogenome.org/gene/9541:PLCD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0S3|||http://purl.uniprot.org/uniprot/G7NYL0 ^@ Cofactor ^@ Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. http://togogenome.org/gene/9541:SNU13 ^@ http://purl.uniprot.org/uniprot/Q25MP7|||http://purl.uniprot.org/uniprot/Q4R5C6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||Identified in the spliceosome B complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Interacts with RAD17 and PRPF31. The complex formed by SNU13 and PRPF31 binds U4 snRNA. The complex formed by SNU13 and PRPF31 binds also U4atac snRNA, a characteristic component of specific, less abundant spliceosomal complexes.|||Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.|||Nucleus|||nucleolus http://togogenome.org/gene/9541:MC2R ^@ http://purl.uniprot.org/uniprot/G7PWB1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).|||Membrane|||Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP). http://togogenome.org/gene/9541:SSH3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYZ4 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/9541:TAS2R39 ^@ http://purl.uniprot.org/uniprot/A0A7N9CZT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9541:TBX19 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKI5|||http://purl.uniprot.org/uniprot/G8F353 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:MRPS10 ^@ http://purl.uniprot.org/uniprot/I7GH86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS10 family.|||Mitochondrion http://togogenome.org/gene/9541:TRAPPC11 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5B8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPPC11 family.|||Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.|||cis-Golgi network http://togogenome.org/gene/9541:THRAP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZY3|||http://purl.uniprot.org/uniprot/A0A7N9D4M1|||http://purl.uniprot.org/uniprot/A0A7N9DCY1 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/9541:ATP1B2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X586 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9541:GNAI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8P3 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9541:DDX58 ^@ http://purl.uniprot.org/uniprot/G7PS60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9541:ADAMTS12 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYD3 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:SPIN4 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5W0|||http://purl.uniprot.org/uniprot/G7Q2W1 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/9541:LOC102133993 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTV2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9541:NDNF ^@ http://purl.uniprot.org/uniprot/A0A2K5WA13|||http://purl.uniprot.org/uniprot/A0A2K5WA75 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:TMEM107 ^@ http://purl.uniprot.org/uniprot/A0A2K5V603 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:KRT78 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ26|||http://purl.uniprot.org/uniprot/A0A2K5VZ54 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:ATF1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPW8|||http://purl.uniprot.org/uniprot/G7PIA6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MYOZ2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6N6|||http://purl.uniprot.org/uniprot/G7P662 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9541:EPHA7 ^@ http://purl.uniprot.org/uniprot/A0A8J8XWR7|||http://purl.uniprot.org/uniprot/G7P422 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GNGT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9541:LRRC8C ^@ http://purl.uniprot.org/uniprot/A0A8J8YIA7|||http://purl.uniprot.org/uniprot/G7NTM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TMEM201 ^@ http://purl.uniprot.org/uniprot/A0A2K5WT53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM201 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9541:DPH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN46 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family. DPH2 subfamily.|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit. http://togogenome.org/gene/9541:PAICS ^@ http://purl.uniprot.org/uniprot/A0A2K5V7L2|||http://purl.uniprot.org/uniprot/I7G760 ^@ Similarity|||Subunit ^@ Homooctamer.|||In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.|||In the N-terminal section; belongs to the SAICAR synthetase family. http://togogenome.org/gene/9541:ERGIC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVV1|||http://purl.uniprot.org/uniprot/A0A7N9CS93|||http://purl.uniprot.org/uniprot/Q4R5C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ERGIC family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||May form a heteromeric complex composed of ERGIC1, ERGIC2 and ERGIC3 (By similarity). Interacts with ERGIC3, the interaction is required for the stable expression of both proteins (By similarity). May interact with EEF1A1 (By similarity).|||Membrane|||Nucleus|||Plays a role in transport between endoplasmic reticulum and Golgi.|||Possible role in transport between endoplasmic reticulum and Golgi.|||cis-Golgi network membrane http://togogenome.org/gene/9541:PCSK9 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Cell surface|||Cytoplasm|||Endoplasmic reticulum|||Endosome|||Golgi apparatus|||Lysosome http://togogenome.org/gene/9541:PPFIA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXP8|||http://purl.uniprot.org/uniprot/A0A2K5UXS7|||http://purl.uniprot.org/uniprot/A0A2K5UXU1|||http://purl.uniprot.org/uniprot/A0A2K5UXX5|||http://purl.uniprot.org/uniprot/A0A2K5UXY9 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/9541:ELP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ELP2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:LOC102127106 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PARI family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:REM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4C9 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:HOXA6 ^@ http://purl.uniprot.org/uniprot/A0A8J8YSD7|||http://purl.uniprot.org/uniprot/G7P0P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9541:MAPKAPK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9A9|||http://purl.uniprot.org/uniprot/G7NZY5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:GPR161 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLY0|||http://purl.uniprot.org/uniprot/A0A2K5WLZ7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:KIZ ^@ http://purl.uniprot.org/uniprot/A0A2K5TRT4|||http://purl.uniprot.org/uniprot/A0A2K5TRT6|||http://purl.uniprot.org/uniprot/A0A2K5TRU3|||http://purl.uniprot.org/uniprot/A0A2K5TRV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the kizuna family.|||Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.|||centrosome|||cilium basal body http://togogenome.org/gene/9541:POLR2G ^@ http://purl.uniprot.org/uniprot/A0A2K5U485|||http://purl.uniprot.org/uniprot/I7GM47 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.|||Nucleus http://togogenome.org/gene/9541:AMER2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UI73 ^@ Similarity ^@ Belongs to the Amer family. http://togogenome.org/gene/9541:SNX9 ^@ http://purl.uniprot.org/uniprot/Q4R870 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/9541:CLVS2 ^@ http://purl.uniprot.org/uniprot/G7P389|||http://purl.uniprot.org/uniprot/Q95KF7 ^@ Domain|||Function|||Miscellaneous|||Subcellular Location Annotation|||Subunit ^@ Binding to PtdIns(3,5)P2 is not required for localization.|||Early endosome membrane|||Endosome membrane|||Forms a complex with clathrin heavy chain and gamma-adaptin.|||Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity).|||The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2.|||Vesicle|||clathrin-coated vesicle|||trans-Golgi network membrane http://togogenome.org/gene/9541:GPR101 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDN8|||http://purl.uniprot.org/uniprot/G7Q1T8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:LOC102133037 ^@ http://purl.uniprot.org/uniprot/Q4R4D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NXF family.|||Cytoplasm http://togogenome.org/gene/9541:KCNK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Cell membrane|||Cytoplasmic vesicle|||Endosome|||Membrane|||Perikaryon|||Recycling endosome|||Synaptic cell membrane|||Vesicle|||dendrite http://togogenome.org/gene/9541:MAT2A ^@ http://purl.uniprot.org/uniprot/Q4R924 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.|||Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. http://togogenome.org/gene/9541:ADA ^@ http://purl.uniprot.org/uniprot/A0A2K5VY21|||http://purl.uniprot.org/uniprot/A0A2K5VY31|||http://purl.uniprot.org/uniprot/A0A2K5VY71|||http://purl.uniprot.org/uniprot/A0A7N9DHL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Cell junction|||Cell membrane|||Cytoplasmic vesicle lumen http://togogenome.org/gene/9541:DEFB110 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRP6|||http://purl.uniprot.org/uniprot/G7P4U6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:MTMR10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WN82 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9541:LOC102145093 ^@ http://purl.uniprot.org/uniprot/Q4R9D1 ^@ Function|||PTM|||Similarity|||Subunit ^@ Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.|||Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Its degradation plays a central role in APC/C regulation, allowing cyclin-A accumulation before S phase entry. APC/C substrates inhibit the autoubiquitination of UBE2C/UBCH10 but not its E2 function, hence APC/C remaining active until its substrates have been destroyed.|||Belongs to the ubiquitin-conjugating enzyme family.|||Component of the APC/C complex, composed of at least 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Within this complex, directly interacts with ANAPC2. http://togogenome.org/gene/9541:PDCD4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWN0 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/9541:ISL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBK8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ZNF830 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJV5 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus speckle http://togogenome.org/gene/9541:RXRB ^@ http://purl.uniprot.org/uniprot/A0A2K5WBN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Nucleus http://togogenome.org/gene/9541:GHITM ^@ http://purl.uniprot.org/uniprot/A0A2K5VIA7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:SMPD2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XLY1|||http://purl.uniprot.org/uniprot/G7P3P3 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/9541:CHRNA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:SDHA ^@ http://purl.uniprot.org/uniprot/I7GH33 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9541:LOC102129860 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUY6 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/9541:GOLPH3L ^@ http://purl.uniprot.org/uniprot/A0A2K5VZV4|||http://purl.uniprot.org/uniprot/G8F4A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:AP1S3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||clathrin-coated pit http://togogenome.org/gene/9541:IFT57 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT57 family.|||cilium basal body http://togogenome.org/gene/9541:GPC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5G1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan that bears heparan sulfate. http://togogenome.org/gene/9541:AKR1A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W354|||http://purl.uniprot.org/uniprot/A0A2K5W359|||http://purl.uniprot.org/uniprot/G8F2B0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the aldo/keto reductase family.|||Cell membrane|||Membrane|||Monomer.|||cytosol http://togogenome.org/gene/9541:ACTG1 ^@ http://purl.uniprot.org/uniprot/Q4R4H6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:KIF17 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJL7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:CNOT6L ^@ http://purl.uniprot.org/uniprot/A0A2K5VLN0|||http://purl.uniprot.org/uniprot/A0A2K5VLN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCR4/nocturin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:MMP28 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAD8 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9541:CD2 ^@ http://purl.uniprot.org/uniprot/Q6SZ61 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function (By similarity).|||Cell membrane|||Interacts with CD48 (By similarity). Interacts with CD58 (LFA-3) (By similarity). Interacts with CD2AP (By similarity). Interacts with PSTPIP1 (By similarity). Interacts with FCGR3A; this interaction modulates NK cell activation and cytotoxicity. http://togogenome.org/gene/9541:ATL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VA83 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9541:RAP2B ^@ http://purl.uniprot.org/uniprot/A0A2K5UCT0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9541:EDN2 ^@ http://purl.uniprot.org/uniprot/G7NUE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9541:ALDH9A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7N6|||http://purl.uniprot.org/uniprot/G7NU30|||http://purl.uniprot.org/uniprot/I7GA13 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9541:SLC50A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TV84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SWEET sugar transporter family.|||Membrane http://togogenome.org/gene/9541:PEX14 ^@ http://purl.uniprot.org/uniprot/I7GKL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-14 family.|||Component of the peroxisomal translocation machinery.|||Peroxisome membrane http://togogenome.org/gene/9541:HECTD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKG5 ^@ Function|||Similarity ^@ Belongs to the UPL family. K-HECT subfamily.|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. http://togogenome.org/gene/9541:LOC102120544 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFL2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family. http://togogenome.org/gene/9541:POLR1C ^@ http://purl.uniprot.org/uniprot/A0A2K5WSZ6|||http://purl.uniprot.org/uniprot/A0A7N9DE58|||http://purl.uniprot.org/uniprot/G8F4F6 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/9541:GUSB ^@ http://purl.uniprot.org/uniprot/A0A2K5WXG5 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 2 family.|||Homotetramer.|||Inhibited by L-aspartic acid.|||Lysosome|||Plays an important role in the degradation of dermatan and keratan sulfates. http://togogenome.org/gene/9541:SPP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL74|||http://purl.uniprot.org/uniprot/G7P5W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the osteopontin family.|||Secreted http://togogenome.org/gene/9541:TMEM176A ^@ http://purl.uniprot.org/uniprot/A0A8J8Y9M3|||http://purl.uniprot.org/uniprot/G7P209 ^@ Similarity ^@ Belongs to the TMEM176 family. http://togogenome.org/gene/9541:SMPDL3A ^@ http://purl.uniprot.org/uniprot/A0A2K5VG13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Secreted http://togogenome.org/gene/9541:MFSD9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXG3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SLC16A1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTQ4|||http://purl.uniprot.org/uniprot/G7NW70|||http://purl.uniprot.org/uniprot/I7GN62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Cell membrane|||Membrane|||Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. http://togogenome.org/gene/9541:PDIA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9541:SLC2A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VV24 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Cell projection|||Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Perikaryon|||Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm. http://togogenome.org/gene/9541:RPL9 ^@ http://purl.uniprot.org/uniprot/G7P5F4|||http://purl.uniprot.org/uniprot/Q5IFJ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm http://togogenome.org/gene/9541:GRAMD1A ^@ http://purl.uniprot.org/uniprot/A0A2K5V6W0|||http://purl.uniprot.org/uniprot/A0A2K5V6Z5|||http://purl.uniprot.org/uniprot/G7PX77 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:C19H19orf12 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4P1|||http://purl.uniprot.org/uniprot/A0A7N9D9S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the C19orf12 family.|||Mitochondrion membrane http://togogenome.org/gene/9541:COQ7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUY7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:KCNH4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8P0 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/9541:SNAP91 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVQ7|||http://purl.uniprot.org/uniprot/A0A2K5VVV8|||http://purl.uniprot.org/uniprot/A0A2K5VW25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PICALM/SNAP91 family.|||Membrane http://togogenome.org/gene/9541:ITK ^@ http://purl.uniprot.org/uniprot/A0A2K5X9J3|||http://purl.uniprot.org/uniprot/G7P6R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9541:PAPSS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4J6|||http://purl.uniprot.org/uniprot/G7P619 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/9541:TMEM120B ^@ http://purl.uniprot.org/uniprot/A0A2K5WAY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM120 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9541:VDAC1 ^@ http://purl.uniprot.org/uniprot/I7G2H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic mitochondrial porin family.|||Cell membrane|||Membrane|||Membrane raft http://togogenome.org/gene/9541:LOC102125690 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWK1|||http://purl.uniprot.org/uniprot/A0A2K5VWL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCP1 family.|||May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).|||Nucleus|||spindle pole http://togogenome.org/gene/9541:SLCO4C1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102117659 ^@ http://purl.uniprot.org/uniprot/A0A2K5VE10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-defensin family.|||Secreted http://togogenome.org/gene/9541:TRMT13 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y3H0|||http://purl.uniprot.org/uniprot/G7NV26 ^@ Function|||Similarity ^@ Belongs to the methyltransferase TRM13 family.|||tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). http://togogenome.org/gene/9541:CPT1B ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ22|||http://purl.uniprot.org/uniprot/G7PG77|||http://purl.uniprot.org/uniprot/Q4R7P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:WARS1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZ21|||http://purl.uniprot.org/uniprot/G7PBM3 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:KAT2A ^@ http://purl.uniprot.org/uniprot/A0A2K5TNE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. GCN5 subfamily.|||Nucleus|||centrosome http://togogenome.org/gene/9541:PLA2G2C ^@ http://purl.uniprot.org/uniprot/A0A2K5VRP4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9541:PTP4A3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YRA9|||http://purl.uniprot.org/uniprot/G7PD16 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9541:GLA ^@ http://purl.uniprot.org/uniprot/A0A2K5V2Q7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/9541:PPP6R3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7U7|||http://purl.uniprot.org/uniprot/A0A2K5W7W4|||http://purl.uniprot.org/uniprot/A0A2K5W7W6|||http://purl.uniprot.org/uniprot/A0A2K5W865|||http://purl.uniprot.org/uniprot/A0A2K5W872|||http://purl.uniprot.org/uniprot/G7PP54 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/9541:MAGOH ^@ http://purl.uniprot.org/uniprot/A0A8J8XPY4|||http://purl.uniprot.org/uniprot/G7NVQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/9541:WLS ^@ http://purl.uniprot.org/uniprot/A0A2K5UNV2|||http://purl.uniprot.org/uniprot/A0A2K5UNY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the wntless family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:MAP3K9 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0R9 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Homodimer.|||Homodimerization via the leucine zipper domains is required for autophosphorylation. http://togogenome.org/gene/9541:GSG1L ^@ http://purl.uniprot.org/uniprot/A0A2K5WEV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/9541:APEX1 ^@ http://purl.uniprot.org/uniprot/G8F5P8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/9541:KRT4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9Q7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:NOP58 ^@ http://purl.uniprot.org/uniprot/G7PL78|||http://purl.uniprot.org/uniprot/Q4R779 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NOP5/NOP56 family.|||Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins SNU13, NOP56, NOP58 and FBL assemble stepwise onto the snoRNA. Interacts with NOPCHAP1, NUFIP1, RUVBL1 and RUVBL2; NOPCHAP1 bridges the association of NOP58 with RUVBL1:RUVBL2 and NUFIP1. Interacts with PIH1D1.|||Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (By similarity).|||Sumoylation is essential for high-affinity binding to snoRNAs.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9541:LOC102117357 ^@ http://purl.uniprot.org/uniprot/G7Q2J7|||http://purl.uniprot.org/uniprot/Q60HE4 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction (By similarity).|||Homodimer; disulfide-linked. Component of a complex, at least composed of TSPAN12, FZD4, LRP5/6 and norrin (NDP). Binds FZD4 with high affinity. Interacts with LRP6 (via Beta-propellers 1 and 2).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:NKX6-3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X268|||http://purl.uniprot.org/uniprot/G7PD94 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CEP43 ^@ http://purl.uniprot.org/uniprot/A0A2K5X091|||http://purl.uniprot.org/uniprot/A0A2K5X0K7|||http://purl.uniprot.org/uniprot/A0A2K5X0L0|||http://purl.uniprot.org/uniprot/Q4R7V3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CEP43 family.|||Homodimer. Part of a ternary complex that contains CEP350, CEP43 and MAPRE1. Interacts directly with CEP350 and MAPRE1. Interacts with CEP19. Interacts (via N-terminus) with CEP350 (via C-terminus).|||Required for anchoring microtubules to the centrosomes. Required for ciliation.|||centriole|||centrosome|||cilium basal body http://togogenome.org/gene/9541:GSDME ^@ http://purl.uniprot.org/uniprot/A0A2K5VUV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102125111 ^@ http://purl.uniprot.org/uniprot/A0A7N9D5L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9541:SV2B ^@ http://purl.uniprot.org/uniprot/A0A2K5U6B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9541:KRT5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMJ9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:SPICE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMY0 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CEP120.|||centriole|||spindle http://togogenome.org/gene/9541:RTCA ^@ http://purl.uniprot.org/uniprot/Q4R3J0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).|||Monomer.|||nucleoplasm http://togogenome.org/gene/9541:PITRM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W861 ^@ Subunit ^@ Monomer and homodimer; homodimerization is induced by binding of the substrate. http://togogenome.org/gene/9541:ATAD2B ^@ http://purl.uniprot.org/uniprot/A0A2K5WQJ1|||http://purl.uniprot.org/uniprot/G7PLQ5 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9541:CORIN ^@ http://purl.uniprot.org/uniprot/A0A2K5UDA0|||http://purl.uniprot.org/uniprot/A0A2K5UDA2 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ST3GAL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VC45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:PPARA ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0L9|||http://purl.uniprot.org/uniprot/G7PFY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.|||Nucleus http://togogenome.org/gene/9541:CTSA ^@ http://purl.uniprot.org/uniprot/A0A2K5TQF9 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9541:MICAL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mical family.|||Cytoplasm http://togogenome.org/gene/9541:POLR2J ^@ http://purl.uniprot.org/uniprot/A0A2K5X258 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.|||Nucleus http://togogenome.org/gene/9541:DCC ^@ http://purl.uniprot.org/uniprot/A0A2K5V8I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. DCC family.|||Membrane http://togogenome.org/gene/9541:SLC6A6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMS4|||http://purl.uniprot.org/uniprot/A0A2K5WMU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:E2F1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W061 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9541:LOC102124022 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY34|||http://purl.uniprot.org/uniprot/G7PXB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TYROBP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:GTF2H1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5Z2|||http://purl.uniprot.org/uniprot/A0A2K5V602 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/9541:SIRT5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3X0 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sirtuin family. Class III subfamily.|||Binds 1 zinc ion per subunit.|||In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity.|||Mitochondrion|||Monomer. Homodimer. Interacts with CPS1.|||NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox.|||Nucleus|||cytosol http://togogenome.org/gene/9541:FBXO24 ^@ http://purl.uniprot.org/uniprot/Q4R327 ^@ Function|||Subunit ^@ Directly interacts with SKP1 and CUL1.|||Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. http://togogenome.org/gene/9541:XRCC4 ^@ http://purl.uniprot.org/uniprot/Q4R3G3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XRCC4 subfamily.|||Nucleus http://togogenome.org/gene/9541:SLC25A35 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM58|||http://purl.uniprot.org/uniprot/A0A7N9CM21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:NME9 ^@ http://purl.uniprot.org/uniprot/A0A2K5V278|||http://purl.uniprot.org/uniprot/A0A8J8XRC5|||http://purl.uniprot.org/uniprot/G7P034 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9541:ATP6V1G1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSA6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9541:KHDC4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYR8|||http://purl.uniprot.org/uniprot/G7NV70 ^@ Similarity ^@ Belongs to the KHDC4 family. http://togogenome.org/gene/9541:PARP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARTD/PARP family.|||Nucleus http://togogenome.org/gene/9541:DDX59 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4U4|||http://purl.uniprot.org/uniprot/A0A2K5U4W3 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX59 subfamily. http://togogenome.org/gene/9541:PPME1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXG5|||http://purl.uniprot.org/uniprot/I7GKE0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the AB hydrolase superfamily.|||Binds PPP2CA and PPP2CB.|||Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. http://togogenome.org/gene/9541:CDH3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPM3 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:GUK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYD7|||http://purl.uniprot.org/uniprot/A0A2K5WYM4 ^@ Similarity ^@ Belongs to the guanylate kinase family. http://togogenome.org/gene/9541:RPL31 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQZ0|||http://purl.uniprot.org/uniprot/G7NZE1 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9541:PMPCA ^@ http://purl.uniprot.org/uniprot/A0A2K5TWC6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M16 family.|||Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion matrix|||Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. http://togogenome.org/gene/9541:CRLS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1X4|||http://purl.uniprot.org/uniprot/Q4R7S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/9541:FGB ^@ http://purl.uniprot.org/uniprot/A0A8J8XQ55|||http://purl.uniprot.org/uniprot/G7P6F7 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/9541:AFG3L2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEI6 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/9541:CUL4A ^@ http://purl.uniprot.org/uniprot/A0A2K5VIT2|||http://purl.uniprot.org/uniprot/A0A2K5VIU5 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9541:LOC102136134 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:MS4A14 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5E8 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9541:NCR3 ^@ http://purl.uniprot.org/uniprot/G7P4P5|||http://purl.uniprot.org/uniprot/P61483 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the natural cytotoxicity receptor (NCR) family.|||Cell membrane|||Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG that promote DC maturation.|||Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.|||Membrane http://togogenome.org/gene/9541:JPT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:SERPINA5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKL7 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:AP4M1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U641 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.|||Early endosome|||trans-Golgi network membrane http://togogenome.org/gene/9541:NDUFB2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CLV3|||http://purl.uniprot.org/uniprot/I7GKV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:VEGFC ^@ http://purl.uniprot.org/uniprot/A0A2K5WBI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/9541:NELL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1B5|||http://purl.uniprot.org/uniprot/G7PHM9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PDP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YJS8|||http://purl.uniprot.org/uniprot/G7Q1C0 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9541:SPAM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3E3|||http://purl.uniprot.org/uniprot/Q4R6A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 56 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:HSD17B6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZT4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:ITGAM ^@ http://purl.uniprot.org/uniprot/A0A2K5UU26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9541:LOC102142852 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFS0 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9541:GBF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W603|||http://purl.uniprot.org/uniprot/G7PDU4 ^@ Subcellular Location Annotation ^@ Golgi apparatus http://togogenome.org/gene/9541:LCK ^@ http://purl.uniprot.org/uniprot/A0A2K5UWC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9541:ACTG2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XMV4|||http://purl.uniprot.org/uniprot/G7PMI2 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:ACD ^@ http://purl.uniprot.org/uniprot/A0A2K5WKE0 ^@ Subcellular Location Annotation ^@ Nucleus|||telomere http://togogenome.org/gene/9541:MID1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YI77|||http://purl.uniprot.org/uniprot/G7Q274 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.|||Nucleus|||cytoskeleton http://togogenome.org/gene/9541:PWP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PWP2 family.|||nucleolus http://togogenome.org/gene/9541:ADD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJN0 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/9541:LOC102132587 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCI0 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9541:ATP6V1A ^@ http://purl.uniprot.org/uniprot/A0A2K5TMW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||clathrin-coated vesicle membrane|||secretory vesicle http://togogenome.org/gene/9541:C2H3orf70 ^@ http://purl.uniprot.org/uniprot/A0A7N9D6P6 ^@ Similarity ^@ Belongs to the UPF0524 family. http://togogenome.org/gene/9541:ATG4D ^@ http://purl.uniprot.org/uniprot/A0A2K5U2I9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9541:EIF3K ^@ http://purl.uniprot.org/uniprot/A0A2K5X240|||http://purl.uniprot.org/uniprot/G8F5R8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit K family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:LINGO1 ^@ http://purl.uniprot.org/uniprot/Q9N008 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).|||Homotetramer. Forms a ternary complex with RTN4R/NGFR and RTN4R/TNFRSF19 (By similarity). Interacts with NGRF, RTN4R and MYT1L (By similarity).|||N-glycosylated. Contains predominantly high-mannose glycans (By similarity).|||The intracellular domain of LINGO1 interacts with MYT1L. http://togogenome.org/gene/9541:C3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPN1 ^@ Function|||Subcellular Location Annotation ^@ C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.|||Secreted http://togogenome.org/gene/9541:GPR50 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGA7|||http://purl.uniprot.org/uniprot/G7Q1X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102118065 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJS7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9541:ILVBL ^@ http://purl.uniprot.org/uniprot/A0A2K5USE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TPP enzyme family.|||Membrane http://togogenome.org/gene/9541:FGF20 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCR8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:PSMA4 ^@ http://purl.uniprot.org/uniprot/Q4R932 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. http://togogenome.org/gene/9541:ADGRD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UX44|||http://purl.uniprot.org/uniprot/A0A2K5UX70 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:TMED3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9541:AP1S2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTY7|||http://purl.uniprot.org/uniprot/A0A2K5TU05|||http://purl.uniprot.org/uniprot/A0A7N9DB11|||http://purl.uniprot.org/uniprot/A0A8J8XS11|||http://purl.uniprot.org/uniprot/G7Q2A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||clathrin-coated pit http://togogenome.org/gene/9541:ACYP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5USW4 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/9541:GNGT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U966 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9541:ERBIN ^@ http://purl.uniprot.org/uniprot/A0A2K5V407|||http://purl.uniprot.org/uniprot/A0A2K5V423|||http://purl.uniprot.org/uniprot/A0A2K5V490 ^@ Similarity ^@ Belongs to the LAP (LRR and PDZ) protein family. http://togogenome.org/gene/9541:FAR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V668 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acyl-CoA reductase family.|||Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.|||Peroxisome membrane http://togogenome.org/gene/9541:SNTG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||cytoskeleton http://togogenome.org/gene/9541:GFOD1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XSS3|||http://purl.uniprot.org/uniprot/G7P4F9 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/9541:P2RY4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UD43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ATP7A ^@ http://purl.uniprot.org/uniprot/A0A2K5X0T9|||http://purl.uniprot.org/uniprot/A0A2K5X0U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:HRH4 ^@ http://purl.uniprot.org/uniprot/Q3V8G8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:LRRC7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWW0 ^@ Similarity ^@ Belongs to the LAP (LRR and PDZ) protein family. http://togogenome.org/gene/9541:LHFPL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8R0|||http://purl.uniprot.org/uniprot/A0A2K5W8R3|||http://purl.uniprot.org/uniprot/G7Q3H7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:MANEAL ^@ http://purl.uniprot.org/uniprot/A0A2K5W9M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:ENTPD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VC94|||http://purl.uniprot.org/uniprot/A0A2K5VCB1|||http://purl.uniprot.org/uniprot/G7NYI6 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9541:FAIM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9541:HACD3 ^@ http://purl.uniprot.org/uniprot/I7GJV7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:ITGB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Membrane http://togogenome.org/gene/9541:SERPINB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTD0|||http://purl.uniprot.org/uniprot/G7P4B6 ^@ Similarity ^@ Belongs to the serpin family. Ov-serpin subfamily. http://togogenome.org/gene/9541:GPR37 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL99 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:HNRNPU ^@ http://purl.uniprot.org/uniprot/A0A2K5TPK4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102145097 ^@ http://purl.uniprot.org/uniprot/A0A2K5UK91 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ARL1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CXT6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9541:RPLP2 ^@ http://purl.uniprot.org/uniprot/I7GJM4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/9541:SLITRK4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMT4 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9541:HOATZ ^@ http://purl.uniprot.org/uniprot/A0A2K5W2W6 ^@ Similarity ^@ Belongs to the HOATZ family. http://togogenome.org/gene/9541:NXF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUK3|||http://purl.uniprot.org/uniprot/A0A2K5VUT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NXF family.|||Cytoplasm http://togogenome.org/gene/9541:CHRM4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XC81|||http://purl.uniprot.org/uniprot/G7PQB4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. http://togogenome.org/gene/9541:SST ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0N9|||http://purl.uniprot.org/uniprot/G7NYN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/9541:C11H12orf57 ^@ http://purl.uniprot.org/uniprot/A0A7N9IC88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0456 family.|||Cytoplasm http://togogenome.org/gene/9541:IDE ^@ http://purl.uniprot.org/uniprot/A0A2K5TUC3|||http://purl.uniprot.org/uniprot/A0A2K5TUD2 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9541:VAMP3 ^@ http://purl.uniprot.org/uniprot/Q25MJ3|||http://purl.uniprot.org/uniprot/Q4R8T0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synaptobrevin family.|||Early endosome membrane|||Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum (By similarity). Interacts with BAIAP3; this interaction is increased in the presence of calcium (By similarity). Interacts with PICALM (By similarity).|||Membrane|||Recycling endosome membrane|||SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.|||Ubiquitinated by RNF167 at Lys-66, Lys-68 and Lys-77, regulating the recycling endosome pathway.|||synaptosome http://togogenome.org/gene/9541:LOC102134374 ^@ http://purl.uniprot.org/uniprot/G7P6T4|||http://purl.uniprot.org/uniprot/Q4R6P8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Cytoplasm|||Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.|||Membrane http://togogenome.org/gene/9541:LOC102130507 ^@ http://purl.uniprot.org/uniprot/Q4R4F8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMN family.|||Cajal body|||Cytoplasm|||Cytoplasmic granule|||Homooligomer; may form higher order homooligomers in the dimer to octamer range. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Component of an import snRNP complex composed of KPNB1, RNUT1, SMN1 and ZNF259. Interacts with DDX20, FBL, NOLA1, RNUT1, SYNCRIP and with several spliceosomal snRNP core Sm proteins, including SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE and ILF3. Interacts with GEMIN2; the interaction is direct. Interacts with GEMIN3; the interaction is direct. Interacts with GEMIN8; the interaction is direct. Interacts with SNRPB; the interaction is direct. Interacts (via Tudor domain) with SNRPD1 (via C-terminus); the interaction is direct. Interacts with SNRPD2; the interaction is direct. Interacts (via Tudor domain) with SNRPD3 (via C-terminus); the interaction is direct. Interacts with SNRPE; the interaction is direct. Interacts with OSTF1, LSM10, LSM11 and RPP20/POP7. Interacts (via C-terminal region) with ZPR1 (via C-terminal region). Interacts (via Tudor domain) with COIL. Interacts with SETX; recruits SETX to POLR2A. Interacts with POLR2A (via the C-terminal domain (CTD)). Interacts with PRMT5. Interacts with XRN2. Interacts (via C-terminus) with FMR1 (via C-terminus); the interaction is direct and occurs in a RNA-independent manner. Interacts (via Tudor domain) with SF3B2 ('Arg-508'-methylated form). Interacts with WRAP53/TCAB1. Interacts (via Tudor domain) with ELAVL4 in an RNA-independent manner; the interaction is required for localization of ELAVL4 to RNA granules. Interacts with FRG1.|||Perikaryon|||The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).|||The Tudor domain mediates association with dimethylarginines, which are common in snRNP proteins.|||Z line|||axon|||gem|||neuron projection http://togogenome.org/gene/9541:CHST2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN89 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9541:BAIAP2 ^@ http://purl.uniprot.org/uniprot/Q4R507 ^@ Function|||Subcellular Location Annotation ^@ Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.|||Membrane|||cytoskeleton|||filopodium|||ruffle http://togogenome.org/gene/9541:TMOD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSA0|||http://purl.uniprot.org/uniprot/G7PBH3|||http://purl.uniprot.org/uniprot/Q2PFU3 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:PHACTR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXZ5|||http://purl.uniprot.org/uniprot/A0A2K5WYA5|||http://purl.uniprot.org/uniprot/A0A7N9D260 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin.|||Cytoplasm|||Nucleus|||Synapse http://togogenome.org/gene/9541:SH3YL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSM9|||http://purl.uniprot.org/uniprot/A0A2K5TSP2|||http://purl.uniprot.org/uniprot/A0A2K5TSQ3|||http://purl.uniprot.org/uniprot/A0A7N9D3Y5 ^@ Similarity|||Subunit ^@ Belongs to the SH3YL1 family.|||Interacts with SH3D19. http://togogenome.org/gene/9541:ATP6AP2 ^@ http://purl.uniprot.org/uniprot/Q4R500 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Lysosome membrane|||Membrane|||autophagosome membrane|||clathrin-coated vesicle membrane|||dendritic spine membrane|||synaptic vesicle membrane http://togogenome.org/gene/9541:LPAR4 ^@ http://purl.uniprot.org/uniprot/G7Q339 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:CD93 ^@ http://purl.uniprot.org/uniprot/A0A2K5VH53 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ZNF512 ^@ http://purl.uniprot.org/uniprot/Q95JV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:PPP4R3B ^@ http://purl.uniprot.org/uniprot/A0A2K5WJD8|||http://purl.uniprot.org/uniprot/A0A2K5WJE9|||http://purl.uniprot.org/uniprot/A0A2K5WJI2|||http://purl.uniprot.org/uniprot/A0A8J8XJ84|||http://purl.uniprot.org/uniprot/G7PM87 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9541:CLDN10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHD3|||http://purl.uniprot.org/uniprot/A0A2K5UHD7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:CD37 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5D2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:HSD11B1L ^@ http://purl.uniprot.org/uniprot/Q6Q7D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Secreted http://togogenome.org/gene/9541:EVA1C ^@ http://purl.uniprot.org/uniprot/A0A2K5U5X6 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/9541:MGRN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVG8|||http://purl.uniprot.org/uniprot/A0A2K5UVH2|||http://purl.uniprot.org/uniprot/A0A2K5UVI5 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin ligase. http://togogenome.org/gene/9541:LOC102125581 ^@ http://purl.uniprot.org/uniprot/G7P1K7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9541:TBL1X ^@ http://purl.uniprot.org/uniprot/Q4R8H1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat EBI family.|||F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.|||Homotetramer; dimer of dimers. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with GPS2 (when sumoylated); leading to protect GPS2 against degradation by the proteasome. Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X (By similarity). Probably part of other corepressor complexes, that do not contain NCOR1 and NCOR2. Interacts with histones H2B, H3a and H4. Interacts with MECP2; recruits TBL1X to the heterochromatin foci (By similarity).|||Nucleus http://togogenome.org/gene/9541:TRMT2B ^@ http://purl.uniprot.org/uniprot/A0A2K5VUK1|||http://purl.uniprot.org/uniprot/A0A2K5VUK7 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:MED13 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 13 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9541:DDC ^@ http://purl.uniprot.org/uniprot/A0A2K5ULX8|||http://purl.uniprot.org/uniprot/A2V9Y9 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9541:LHX6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM37|||http://purl.uniprot.org/uniprot/A0A2K5VM87|||http://purl.uniprot.org/uniprot/A0A2K5VMB9|||http://purl.uniprot.org/uniprot/A0A2K5VMC6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FANCM ^@ http://purl.uniprot.org/uniprot/A0A2K5X791 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. http://togogenome.org/gene/9541:ELK3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YAT6|||http://purl.uniprot.org/uniprot/G7PJ37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:TUBA1C ^@ http://purl.uniprot.org/uniprot/A0A805QYG0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/9541:C15H9orf64 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUN8 ^@ Function|||Similarity ^@ Belongs to the queuosine salvage protein family.|||Involved in salvaging queuosine. http://togogenome.org/gene/9541:MBTPS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1G2 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9541:LIPN ^@ http://purl.uniprot.org/uniprot/A0A8J8Y3P4|||http://purl.uniprot.org/uniprot/G7PDH4 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9541:GRIN2B ^@ http://purl.uniprot.org/uniprot/A0A8J8YJG1|||http://purl.uniprot.org/uniprot/G7PJX2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9541:SEMA3D ^@ http://purl.uniprot.org/uniprot/A0A2K5VQE5 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:SPRR3 ^@ http://purl.uniprot.org/uniprot/A0A7N9C8C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornifin (SPRR) family.|||Cytoplasm http://togogenome.org/gene/9541:MED18 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHY7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9541:VPS53 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0U7|||http://purl.uniprot.org/uniprot/A0A2K5U0Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS53 family.|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:NME5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL60 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9541:AHCYL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5H4|||http://purl.uniprot.org/uniprot/A0A2K5X5Z0 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/9541:MTO1 ^@ http://purl.uniprot.org/uniprot/Q4R4P6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmG family.|||Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.|||Mitochondrion http://togogenome.org/gene/9541:KCNN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WM04 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:OPN1SW ^@ http://purl.uniprot.org/uniprot/Q9XS34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane|||Photoreceptor inner segment|||photoreceptor outer segment http://togogenome.org/gene/9541:SLC47A1 ^@ http://purl.uniprot.org/uniprot/A0A0R8GG88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/9541:RPS28 ^@ http://purl.uniprot.org/uniprot/A0A2K5W098|||http://purl.uniprot.org/uniprot/G8F4P1 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS28 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9541:SLC16A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TN74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ASB18 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCK7 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:AOX1 ^@ http://purl.uniprot.org/uniprot/Q5FB27 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ AOX genes evolved from a xanthine oxidoreductase ancestral precursor via a series of gene duplication and suppression/deletion events. Different animal species contain a different complement of AOX genes encoding an equivalent number of AOX isoenzymes. In mammals, the two extremes are represented by certain rodents such as mice and rats, which are endowed with 4 AOX genes, and by humans, whose genome is characterized by a single active gene (PubMed:23263164).|||Belongs to the xanthine dehydrogenase family.|||Binds 1 FAD per subunit.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters per subunit.|||Cytoplasm|||Detected at high levels in liver, also detected in lung, kidney, lacrimal gland and olfactory mucosa.|||Homodimer.|||Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis (By similarity). http://togogenome.org/gene/9541:SUGP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUB1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NUP93 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1A6|||http://purl.uniprot.org/uniprot/G7Q166|||http://purl.uniprot.org/uniprot/Q4R8S7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin interacting component (NIC) family.|||Nucleus envelope|||Nucleus membrane|||Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.|||nuclear pore complex http://togogenome.org/gene/9541:KRT72 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5G3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:DOCK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ63 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9541:DNM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRV6|||http://purl.uniprot.org/uniprot/A0A2K5WRZ9|||http://purl.uniprot.org/uniprot/A0A2K5WS10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.|||cytoskeleton http://togogenome.org/gene/9541:LOC102121548 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ29 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the osteocalcin/matrix Gla protein family.|||Binds strongly to apatite and calcium.|||Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.|||Secreted http://togogenome.org/gene/9541:LCAT ^@ http://purl.uniprot.org/uniprot/A0A2K5WDQ7 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9541:ADAMTS5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X879 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:PTGFR ^@ http://purl.uniprot.org/uniprot/A0A7N9D088 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TENT5D ^@ http://purl.uniprot.org/uniprot/A0A7N9DC55|||http://purl.uniprot.org/uniprot/G8F374 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9541:LIN28A ^@ http://purl.uniprot.org/uniprot/A0A7N9IH37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-28 family.|||nucleolus http://togogenome.org/gene/9541:BTD ^@ http://purl.uniprot.org/uniprot/A0A2K5UBN7 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9541:CCL18 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:GJB1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CAQ4|||http://purl.uniprot.org/uniprot/G8F3U7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with CNST.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9541:CDC14A ^@ http://purl.uniprot.org/uniprot/A0A2K5X9F1|||http://purl.uniprot.org/uniprot/A0A2K5X9G4|||http://purl.uniprot.org/uniprot/A0A2K5X9H4|||http://purl.uniprot.org/uniprot/G7NV31|||http://purl.uniprot.org/uniprot/Q4R5R2 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/9541:BRD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQM2|||http://purl.uniprot.org/uniprot/A0A2K5UQN1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102124950 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ARSH ^@ http://purl.uniprot.org/uniprot/A0A8J8XL05|||http://purl.uniprot.org/uniprot/G7Q249 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9541:METAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VW41 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/9541:ARHGAP26 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXJ4|||http://purl.uniprot.org/uniprot/A0A7N9CJZ9|||http://purl.uniprot.org/uniprot/A0A7N9IDB1 ^@ Subcellular Location Annotation ^@ cytoskeleton|||focal adhesion http://togogenome.org/gene/9541:LOC102123927 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAA9 ^@ Similarity ^@ Belongs to the SPAN-X family. http://togogenome.org/gene/9541:INSIG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V608 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/9541:SPINK2 ^@ http://purl.uniprot.org/uniprot/P34953 ^@ Function|||Subcellular Location Annotation|||Tissue Specificity ^@ As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (By similarity). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin (By similarity).|||More abundant in epididymis than in testis.|||Secreted|||Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin (By similarity).|||acrosome http://togogenome.org/gene/9541:LOC102147033 ^@ http://purl.uniprot.org/uniprot/A0A7N9CD12|||http://purl.uniprot.org/uniprot/G7PJL0 ^@ Similarity ^@ Belongs to the GroES chaperonin family.|||Belongs to the MOB1/phocein family. http://togogenome.org/gene/9541:KEG98_p04 ^@ http://purl.uniprot.org/uniprot/C3W4Z4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9541:ERC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8C8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:ANO10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZC1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:RPA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 2 family.|||Nucleus http://togogenome.org/gene/9541:CCDC90B ^@ http://purl.uniprot.org/uniprot/A0A2K5WFP1|||http://purl.uniprot.org/uniprot/A0A2K5WFQ9 ^@ Similarity ^@ Belongs to the CCDC90 family. http://togogenome.org/gene/9541:LDHD ^@ http://purl.uniprot.org/uniprot/A0A2K5UML6 ^@ Similarity ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family. http://togogenome.org/gene/9541:ADAM17 ^@ http://purl.uniprot.org/uniprot/A0A2K5X241 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:CORO2B ^@ http://purl.uniprot.org/uniprot/A0A2K5USB3 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9541:SI ^@ http://purl.uniprot.org/uniprot/A0A2K5U6U6 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 31 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC102134776 ^@ http://purl.uniprot.org/uniprot/A0A2K5UP92 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/9541:NUDT5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKA0|||http://purl.uniprot.org/uniprot/A0A7N9CQS9 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/9541:PHOSPHO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V191 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/9541:RASGRP2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CIC2 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9541:LIPC ^@ http://purl.uniprot.org/uniprot/A0A2K5VV98|||http://purl.uniprot.org/uniprot/A0A2K5VVL1 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:CUL9 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cullin family.|||Cytoplasm http://togogenome.org/gene/9541:ABLIM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTD1|||http://purl.uniprot.org/uniprot/A0A2K5WTM8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:TRPC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8P8|||http://purl.uniprot.org/uniprot/G7P008 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.|||Membrane|||Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. http://togogenome.org/gene/9541:GATA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYX7|||http://purl.uniprot.org/uniprot/G7Q2N4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ABHD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WW48 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/9541:ENKD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVS6 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9541:MAEA ^@ http://purl.uniprot.org/uniprot/A0A2K5U833|||http://purl.uniprot.org/uniprot/A0A2K5U889|||http://purl.uniprot.org/uniprot/A0A2K5U8C1 ^@ Subcellular Location Annotation ^@ Nucleus matrix|||nucleoplasm http://togogenome.org/gene/9541:KPNA7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXA0 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9541:ALOX5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UID9 ^@ Caution|||Similarity ^@ Belongs to the lipoxygenase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:HMGCS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHJ3|||http://purl.uniprot.org/uniprot/G7NX69 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/9541:SCARB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X784|||http://purl.uniprot.org/uniprot/A0A2K5X789 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9541:OPTN ^@ http://purl.uniprot.org/uniprot/A0A2K5VUU9|||http://purl.uniprot.org/uniprot/Q95KA2 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cytoplasmic vesicle|||Endosome|||Golgi apparatus|||May act by regulating membrane trafficking and cellular morphogenesis.|||Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection.|||Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.|||Recycling endosome|||Self-associates (By similarity). Interacts with HD, GTF3A, TRAF3, TBK1 and MYO6. Interacts (via UBAN) with ubiquitinated TFRC. Interacts with active GTP-bound Rab8 (RAB8A and/or RAB8B). Interacts with TBC1D17. Binds to linear ubiquitin chains. Interacts with LC3 family members MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2; OPTN phosphorylation increases the association (at least with MAP1LC3B). Interacts with RAB12; the interaction may be indirect (By similarity). Interacts with palmitoyltransferase ZDHHC17/HIP14; the interaction does not lead to palmitoylation of OPTN (By similarity). Interacts with CYLD (By similarity). Interacts with TOM1; the interaction is indirect and is mediated by MYO6, which acts as a bridge between TOM1 and OPTN (By similarity).|||The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins.|||Ubiquitin-binding motif (UBAN) is essential for its inhibitory function, subcellular localization and interaction with TBK1.|||Vesicle|||autophagosome|||perinuclear region|||trans-Golgi network http://togogenome.org/gene/9541:USP33 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP20/USP33 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||centrosome|||perinuclear region http://togogenome.org/gene/9541:ABHD16A ^@ http://purl.uniprot.org/uniprot/A0A7N9C8M1|||http://purl.uniprot.org/uniprot/A0A7N9D0E7|||http://purl.uniprot.org/uniprot/Q4R8P0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. ABHD16 family.|||Membrane|||Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (By similarity). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (By similarity). http://togogenome.org/gene/9541:KEG98_p06 ^@ http://purl.uniprot.org/uniprot/C3W4Z2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 3 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Mitochondrion membrane http://togogenome.org/gene/9541:AGPAT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YED8|||http://purl.uniprot.org/uniprot/G7P2Q6 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/9541:FOXP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X233 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:JPH3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/9541:PGD ^@ http://purl.uniprot.org/uniprot/A0A2K5WBE9|||http://purl.uniprot.org/uniprot/I7G9P9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Homodimer. http://togogenome.org/gene/9541:TRMT112 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLA0 ^@ Similarity ^@ Belongs to the TRM112 family. http://togogenome.org/gene/9541:CENPQ ^@ http://purl.uniprot.org/uniprot/Q4R7G2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CENP-Q/OKP1 family.|||Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores.|||Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.|||Nucleus|||centromere http://togogenome.org/gene/9541:DPY19L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WU47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/9541:PPP1R10 ^@ http://purl.uniprot.org/uniprot/A0A8J8XGH1|||http://purl.uniprot.org/uniprot/G7P4L7 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers. http://togogenome.org/gene/9541:PGF ^@ http://purl.uniprot.org/uniprot/A0A2K5VMQ8|||http://purl.uniprot.org/uniprot/A0A2K5VMT8 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9541:PIGO ^@ http://purl.uniprot.org/uniprot/A0A2K5W6E8|||http://purl.uniprot.org/uniprot/G7PS15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:FUT10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAV0|||http://purl.uniprot.org/uniprot/A0A2K5UAV7|||http://purl.uniprot.org/uniprot/A0A2K5UAX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane|||Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. http://togogenome.org/gene/9541:ATPSCKMT ^@ http://purl.uniprot.org/uniprot/I7GAZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANT/ATPSC lysine N-methyltransferase family.|||Mitochondrion membrane http://togogenome.org/gene/9541:CPNE3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVS8 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9541:ALDH1A1 ^@ http://purl.uniprot.org/uniprot/Q4R5G3 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9541:PKM ^@ http://purl.uniprot.org/uniprot/A0A2K5VNC3|||http://purl.uniprot.org/uniprot/A0A2K5VNF3|||http://purl.uniprot.org/uniprot/I7GH00 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/9541:ADAMTS15 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEC5 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:CER1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJN9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:ETFRF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1B3 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9541:CPNE7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKL1 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9541:CDC42SE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSF4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.|||Membrane|||Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.|||cytoskeleton http://togogenome.org/gene/9541:LIPT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLX1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LipB family.|||Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.|||Mitochondrion http://togogenome.org/gene/9541:NOX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VF08|||http://purl.uniprot.org/uniprot/A0A8J8XXT4|||http://purl.uniprot.org/uniprot/G7Q381 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CSH4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.|||Secreted http://togogenome.org/gene/9541:CENPN ^@ http://purl.uniprot.org/uniprot/A0A8J8XL27|||http://purl.uniprot.org/uniprot/G7PZT4 ^@ Similarity ^@ Belongs to the CENP-N/CHL4 family. http://togogenome.org/gene/9541:AGBL5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Midbody|||Nucleus|||cytosol|||spindle http://togogenome.org/gene/9541:SPG21 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGW4|||http://purl.uniprot.org/uniprot/G8F5Q6|||http://purl.uniprot.org/uniprot/Q4R5H6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily.|||Cytoplasm|||Interacts with CD4. Interacts with ALDH16A1.|||May play a role as a negative regulatory factor in CD4-dependent T-cell activation. http://togogenome.org/gene/9541:KRT12 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZW2|||http://purl.uniprot.org/uniprot/G7PUQ0 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:SLCO1B3 ^@ http://purl.uniprot.org/uniprot/L7TAY6|||http://purl.uniprot.org/uniprot/Q5S2D3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:LOC101865451 ^@ http://purl.uniprot.org/uniprot/Q4R7F9 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9541:NXT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHH8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/9541:MCTP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4T4|||http://purl.uniprot.org/uniprot/A0A2K5X4Y1|||http://purl.uniprot.org/uniprot/A0A2K5X595 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:MYO9A ^@ http://purl.uniprot.org/uniprot/A0A2K5UK55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||Cytoplasm|||Membrane|||Synapse|||growth cone http://togogenome.org/gene/9541:ZBED1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJD3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CDC42 ^@ http://purl.uniprot.org/uniprot/Q4R4R6 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Cytoplasm|||Interacts with CDC42EP1, CDC42EP2, CDC42EP3, CDC42EP4, CDC42EP5, CDC42SE1, CDC42SE2, PARD6A, PARD6B and PARD6G (in a GTP-dependent manner). Interacts with activated CSPG4 and with BAIAP2. Interacts with DOCK11/Zizimin2; the interaction activates CDC42 by exchanging GDP for GTP. Interacts with DOCK9; the interaction activates CDC42 by exchanging GDP for GTP. Interacts with DOCK8 (via DHR-2 domain); the interaction activates CDC42 by exchanging GDP for GTP. Interacts with IQGAP1. Interacts with NET1 and ARHGAP33/TCGAP. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ. The GTP-bound form interacts with CCPG1. Interacts with USP6. Interacts with NEK6. Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with ITGB1BP1. Interacts with ARHGDIA; this interaction inactivates and stabilizes CDC42. Interacts with ARHGDIB; this maintains CDC42 in the inactive, GDP-bound form. Interacts in (GTP-bound form) with FNBP1L and ABI1, but only in the presence of FNBP1L.|||Midbody|||Phosphorylated by SRC in an EGF-dependent manner, this stimulates the binding of the Rho-GDP dissociation inhibitor RhoGDI.|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (By similarity).|||Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.|||centrosome|||lamellipodium membrane|||spindle http://togogenome.org/gene/9541:RAB3IL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUQ3 ^@ Similarity ^@ Belongs to the SEC2 family. http://togogenome.org/gene/9541:APPL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VI64 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Nucleus|||phagosome|||ruffle http://togogenome.org/gene/9541:ABL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TT41|||http://purl.uniprot.org/uniprot/A0A2K5TT62 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9541:GPRC6A ^@ http://purl.uniprot.org/uniprot/A0A2K5WIY6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:KAT7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSE2|||http://purl.uniprot.org/uniprot/A0A2K5TSF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9541:HNRNPC ^@ http://purl.uniprot.org/uniprot/A0A2K5U148|||http://purl.uniprot.org/uniprot/I7GH07 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/9541:ABCG5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WA04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9541:LOC101866756 ^@ http://purl.uniprot.org/uniprot/A0A2K5VE04|||http://purl.uniprot.org/uniprot/A0A2K5VE26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NASP family.|||Nucleus http://togogenome.org/gene/9541:PDE1B ^@ http://purl.uniprot.org/uniprot/A0A2K5V7J5|||http://purl.uniprot.org/uniprot/G7PHX1|||http://purl.uniprot.org/uniprot/Q9BE16 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:ST3GAL5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGK2|||http://purl.uniprot.org/uniprot/A0A2K5VGK8|||http://purl.uniprot.org/uniprot/A0A2K5VGM4|||http://purl.uniprot.org/uniprot/A0A7N9D559 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:POLE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0N6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase epsilon subunit B family.|||Nucleus|||Participates in DNA repair and in chromosomal DNA replication. http://togogenome.org/gene/9541:LOC102130413 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFX5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9541:STON2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4K2|||http://purl.uniprot.org/uniprot/A0A2K5X546 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.|||Belongs to the Stoned B family.|||Cytoplasm|||synaptosome http://togogenome.org/gene/9541:GRPR ^@ http://purl.uniprot.org/uniprot/A0A2K5U3F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:DMAP1 ^@ http://purl.uniprot.org/uniprot/G7NUY3|||http://purl.uniprot.org/uniprot/Q2PFQ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:UNC13C ^@ http://purl.uniprot.org/uniprot/A0A2K5W7V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-13 family.|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:LOC102138312 ^@ http://purl.uniprot.org/uniprot/A0A8J8XBQ0|||http://purl.uniprot.org/uniprot/G7PRZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/9541:FBLN5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLE1|||http://purl.uniprot.org/uniprot/A0A2K5VLH4 ^@ Caution|||Similarity ^@ Belongs to the fibulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:CREB3L3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:LOC102125550 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEA5 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9541:TMEM33 ^@ http://purl.uniprot.org/uniprot/A0A8J8XUW8|||http://purl.uniprot.org/uniprot/G7P5H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/9541:AGPAT5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:UPF3B ^@ http://purl.uniprot.org/uniprot/A0A2K5VTM2|||http://purl.uniprot.org/uniprot/A0A2K5VTM6 ^@ Similarity ^@ Belongs to the RENT3 family. http://togogenome.org/gene/9541:SUCLG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWV2|||http://purl.uniprot.org/uniprot/A0A2K5WX63 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.|||Binds 1 Mg(2+) ion per subunit.|||GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.|||Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.|||Mitochondrion http://togogenome.org/gene/9541:PIGF ^@ http://purl.uniprot.org/uniprot/A0A2K5VGY5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:DIMT1 ^@ http://purl.uniprot.org/uniprot/Q95KJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9541:OXCT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 3-oxoacid CoA-transferase family.|||Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.|||Mitochondrion http://togogenome.org/gene/9541:FYN ^@ http://purl.uniprot.org/uniprot/A0A2K5TKJ7|||http://purl.uniprot.org/uniprot/A0A2K5TKN9|||http://purl.uniprot.org/uniprot/A0A8J8XEI0|||http://purl.uniprot.org/uniprot/G7P3M8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9541:NUP85 ^@ http://purl.uniprot.org/uniprot/I7GE27 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup85 family.|||Component of the nuclear pore complex (NPC).|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/9541:PFKFB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V950|||http://purl.uniprot.org/uniprot/G7Q2U3 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9541:ORMDL1 ^@ http://purl.uniprot.org/uniprot/G7PL13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Endoplasmic reticulum membrane|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9541:CRABP1 ^@ http://purl.uniprot.org/uniprot/A0A7N9D888 ^@ Function|||Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors. http://togogenome.org/gene/9541:WDR49 ^@ http://purl.uniprot.org/uniprot/A0A2K5V151 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:MPHOSPH10 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3Z0|||http://purl.uniprot.org/uniprot/A0A7N9CX54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPP10 family.|||Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.|||nucleolus http://togogenome.org/gene/9541:NHSL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFT2 ^@ Similarity ^@ Belongs to the NHS family. http://togogenome.org/gene/9541:PHF5A ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2R2|||http://purl.uniprot.org/uniprot/G7PFN3 ^@ Similarity ^@ Belongs to the PHF5 family. http://togogenome.org/gene/9541:RTP1 ^@ http://purl.uniprot.org/uniprot/Q95JK0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TMEM7 family.|||Cell membrane|||Interacts with olfactory receptors.|||Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs. http://togogenome.org/gene/9541:GYS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYV6|||http://purl.uniprot.org/uniprot/A0A2K5TYW9 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/9541:EFTUD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W206|||http://purl.uniprot.org/uniprot/G7PV09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Nucleus http://togogenome.org/gene/9541:CYP4X1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8R7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:GDPD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDT2|||http://purl.uniprot.org/uniprot/A0A8J8YKA5|||http://purl.uniprot.org/uniprot/G7PN97 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9541:RAB5A ^@ http://purl.uniprot.org/uniprot/P61271 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Cytoplasmic vesicle|||Early endosome membrane|||Endosome membrane|||Interacts with GDI1; this promotes dissociation from membranes; phosphorylation at Ser-84 disrupts this interaction (By similarity). Interacts with GDI2; phosphorylation at Ser-84 disrupts the interaction (By similarity). Interacts with SGSM1 and SGSM3 (By similarity). Interacts with PIK3CB. Interacts with EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with RINL. Interacts with ALS2CL, SUN2, ZFYVE20 and RUFY1. Interacts with RABEP1; one RABEP1 homodimer binds two RAB5A chains, but at opposite sides of the dimer. Interacts with OCRL and INPP5F. May be a component of a complex composed of RAB5A, DYN2 and PIK3C3. Does not interact with the BLOC-3 complex (heterodimer of HPS1 and HPS4). Interacts with CLN5. Interacts with APPL2 (By similarity). Interacts with F8A1/F8A2/F8A3 (By similarity). Found in a complex with F8A1/F8A2/F8A3, HTT and RAB5A; mediates the recruitment of HTT by RAB5A onto early endosomes (By similarity).|||Melanosome|||Membrane|||Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including RAB GDP dissociation inhibitors GDI1 and GDI2.|||Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.|||Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension.Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.|||cytosol|||phagosome membrane|||ruffle http://togogenome.org/gene/9541:LOC102146042 ^@ http://purl.uniprot.org/uniprot/A0A023JBX1 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9541:RARS2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQB1|||http://purl.uniprot.org/uniprot/G7P3K3 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:LAMB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8H4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9541:PYGB ^@ http://purl.uniprot.org/uniprot/A0A2K5TPE2 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/9541:UFL1 ^@ http://purl.uniprot.org/uniprot/Q4R367 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UFL1 family.|||Chromosome|||E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. In response to endoplasmic reticulum stress, recruited to the endoplasmic reticulum membrane by DDRGK1, and mediates ufmylation of proteins such as RPN1 and RPL26/uL24, thereby promoting reticulophagy of endoplasmic reticulum sheets. Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) via ERN1/IRE1-alpha. Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response (By similarity). Regulates inflammation in response to endoplasmic reticulum stress by promoting reticulophagy, leading to inhibit the activity of the NF-kappa-B transcription factor (By similarity). Mediates ufmylation of DDRGK1 and CDK5RAP3; the role of these modifications is however unclear: as both DDRGK1 and CDK5RAP3 act as substrate adapters for ufmylation, it is uncertain whether ufmylation of these proteins is a collateral effect or is required for ufmylation (By similarity). Catalyzes ufmylation of various subunits of the ribosomal complex or associated components, such as RPS3/uS3, RPS20/uS10, RPL10/uL16, RPL26/uL24 and EIF6 (By similarity). Anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition. Also involved in the response to DNA damage: recruited to double-strand break sites following DNA damage and mediates monoufmylation of histone H4. Catalyzes ufmylation of TRIP4, thereby playing a role in nuclear receptor-mediated transcription (By similarity). Required for hematopoietic stem cell function and hematopoiesis. Required for cardiac homeostasis (By similarity).|||Endoplasmic reticulum membrane|||Interacts with DDRGK1 (via PCI domain). Interacts with UFC1. Interacts with RELA. Interacts with TRIP4. Interacts with CDK5RAP3; the interaction is direct. Interacts with NBN; promoting recruitment to double-strand breaks following DNA damage.|||Nucleus|||Ubiquitinated, leading to its degradation by the proteasome. Interaction with CDK5RAP3 protects both proteins against ubiquitination and degradation via the proteasome.|||cytosol http://togogenome.org/gene/9541:GABRA5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UB56 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:FCGRT ^@ http://purl.uniprot.org/uniprot/Q8SPV9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the immunoglobulin superfamily.|||Cell membrane|||Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.|||Endosome membrane|||FcRn complex consists of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer (By similarity). Interacts with albumin/ALB; this interaction regulates ALB homeostasis (By similarity). http://togogenome.org/gene/9541:LOC102123539 ^@ http://purl.uniprot.org/uniprot/A0A8J8YJQ8|||http://purl.uniprot.org/uniprot/G7P2D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:STK39 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYV4|||http://purl.uniprot.org/uniprot/A0A7N9DEN5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/9541:PYGM ^@ http://purl.uniprot.org/uniprot/Q8HXW4 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subunit ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Allosterically regulated through the non-covalent binding of metabolites, being activated by AMP and inhibited by ATP, ADP, and glucose-6-phosphate. The activity is also controlled by post-translational modifications including phosphorylation.|||Belongs to the glycogen phosphorylase family.|||Homodimer. Homotetramer; to form the enzymatically active phosphorylase A.|||Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A. http://togogenome.org/gene/9541:MASP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJY0|||http://purl.uniprot.org/uniprot/A0A2K5UK03 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PARP8 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8E2|||http://purl.uniprot.org/uniprot/A0A2K5W8K0 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9541:EXTL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7X5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:ERGIC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJ67|||http://purl.uniprot.org/uniprot/A0A2K5WJ70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/9541:ACTRT1 ^@ http://purl.uniprot.org/uniprot/Q4R821 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||Cytoplasm|||Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression.|||Nucleus|||cytoskeleton http://togogenome.org/gene/9541:KCNH3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRR6 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/9541:LIX1L ^@ http://purl.uniprot.org/uniprot/A0A2K5UXZ2 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/9541:PPDPFL ^@ http://purl.uniprot.org/uniprot/A0A2K5VPQ9 ^@ Similarity ^@ Belongs to the PPDPF family. http://togogenome.org/gene/9541:MRS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKP9|||http://purl.uniprot.org/uniprot/A0A2K5WKR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:CCN6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL19 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:EPS8L2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHT1 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/9541:CDH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V299 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.|||Membrane|||trans-Golgi network http://togogenome.org/gene/9541:ADAMTS14 ^@ http://purl.uniprot.org/uniprot/A0A2K5U008 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:ALKAL1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XRI4|||http://purl.uniprot.org/uniprot/G7PBU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALKAL family.|||Secreted http://togogenome.org/gene/9541:BET1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYH9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:BAMBI ^@ http://purl.uniprot.org/uniprot/A0A2K5TQC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BAMBI family.|||Membrane|||Negatively regulates TGF-beta signaling. http://togogenome.org/gene/9541:AP5M1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKA5|||http://purl.uniprot.org/uniprot/Q4R6Q7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport.|||Belongs to the adaptor complexes medium subunit family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.|||cytosol http://togogenome.org/gene/9541:SUB1 ^@ http://purl.uniprot.org/uniprot/Q25NQ4|||http://purl.uniprot.org/uniprot/Q4R947 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activity is controlled by protein kinases that target the regulatory region. Phosphorylation inactivates both ds DNA-binding and cofactor function, but does not affect binding to ssDNA (By similarity).|||Belongs to the transcriptional coactivator PC4 family.|||General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA) (By similarity).|||General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).|||Homodimer. Interacts with CSTF2 (By similarity).|||Homodimer. Interacts with CSTF2.|||Nucleus http://togogenome.org/gene/9541:CPLX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJI6|||http://purl.uniprot.org/uniprot/I7GKG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9541:GLRA1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YBP3|||http://purl.uniprot.org/uniprot/G7P8R5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/9541:GLRA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXB3|||http://purl.uniprot.org/uniprot/A0A7N9IDE3|||http://purl.uniprot.org/uniprot/A0A8J8YHI7|||http://purl.uniprot.org/uniprot/G7Q291 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9541:LOC102146005 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMQ0|||http://purl.uniprot.org/uniprot/A0A2K5TMR6|||http://purl.uniprot.org/uniprot/I7GL08|||http://purl.uniprot.org/uniprot/Q4R5L7 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with EIF4G1. Associates with ribosomes.|||nucleoplasm http://togogenome.org/gene/9541:TIE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W685|||http://purl.uniprot.org/uniprot/G7NUW7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:LOXL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2R5|||http://purl.uniprot.org/uniprot/A0A2K5X388|||http://purl.uniprot.org/uniprot/G7PMK3 ^@ Caution|||Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Contains 1 lysine tyrosylquinone.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9541:ISX ^@ http://purl.uniprot.org/uniprot/A0A2K5U076 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:HPS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TN29 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.|||Cytoplasm|||Involved in early stages of melanosome biogenesis and maturation. http://togogenome.org/gene/9541:TPX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VME8|||http://purl.uniprot.org/uniprot/G7PGN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TPX2 family.|||Nucleus|||spindle pole http://togogenome.org/gene/9541:LHX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULQ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NARF ^@ http://purl.uniprot.org/uniprot/A0A2K5W8L6|||http://purl.uniprot.org/uniprot/A0A2K5W8M3 ^@ Similarity ^@ Belongs to the NARF family. http://togogenome.org/gene/9541:ADRA1A ^@ http://purl.uniprot.org/uniprot/A0A2K5US01|||http://purl.uniprot.org/uniprot/A0A2K5US15|||http://purl.uniprot.org/uniprot/G7PCY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||Nucleus membrane|||caveola http://togogenome.org/gene/9541:HDGFL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HDGF family.|||Nucleus http://togogenome.org/gene/9541:ELK1 ^@ http://purl.uniprot.org/uniprot/I7G4D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:SEPTIN1 ^@ http://purl.uniprot.org/uniprot/G7Q0X5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9541:PLA2G4E ^@ http://purl.uniprot.org/uniprot/A0A2K5VTR8 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9541:CYSLTR1 ^@ http://purl.uniprot.org/uniprot/A0A7N9C8W6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:FGG ^@ http://purl.uniprot.org/uniprot/A0A2K5TY00|||http://purl.uniprot.org/uniprot/A0A2K5TY07 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/9541:KLC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/9541:CHUK ^@ http://purl.uniprot.org/uniprot/A0A8J8XNK4|||http://purl.uniprot.org/uniprot/G7PDQ9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:TMEM170B ^@ http://purl.uniprot.org/uniprot/A0A2K5TPY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/9541:IGF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5URR6|||http://purl.uniprot.org/uniprot/A0A2K5URS7|||http://purl.uniprot.org/uniprot/A0A2K5URV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9541:UNC93A ^@ http://purl.uniprot.org/uniprot/A0A2K5WLI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/9541:TIPIN ^@ http://purl.uniprot.org/uniprot/A0A2K5UYX1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSM3 family.|||Nucleus|||Plays an important role in the control of DNA replication and the maintenance of replication fork stability. http://togogenome.org/gene/9541:TMED6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XY41|||http://purl.uniprot.org/uniprot/G7Q1I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:CYP1A1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YNV8|||http://purl.uniprot.org/uniprot/G7P943|||http://purl.uniprot.org/uniprot/P33616 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15alpha and C16alpha positions. Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation. Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system. Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer. May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent).|||Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Cytoplasm|||Endoplasmic reticulum membrane|||Interacts with cytosolic chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria. Interacts (via mitochondrial targeting signal) with TOMM40 (via N-terminus); this interaction is required for translocation across the mitochondrial outer membrane.|||Membrane|||Microsome membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:NPC2 ^@ http://purl.uniprot.org/uniprot/P61918 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the NPC2 family.|||Binds cholesterol in a hydrophobic pocket; there are no hydrogen bonds between the sterol and the protein.|||Detected in epididymis.|||Endoplasmic reticulum|||Interacts with NPC1 (via the second lumenal domain) in a cholestrol-dependent manner. Interacts with NUS1/NgBR, the interaction stabilizes NCP2 and regulates cholesterol trafficking. Interacts with DHDDS. Interacts with NEDD4L (via C2 domain). Interacts with NPC1L1.|||Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).|||Lysosome|||Secreted http://togogenome.org/gene/9541:KIF18B ^@ http://purl.uniprot.org/uniprot/A0A2K5W821 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:EEF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TK27 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. http://togogenome.org/gene/9541:TRAF6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family. A subfamily.|||Lipid droplet|||Nucleus|||cell cortex http://togogenome.org/gene/9541:INPP5K ^@ http://purl.uniprot.org/uniprot/A0A2K5UPQ6 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. http://togogenome.org/gene/9541:LAMC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9N8|||http://purl.uniprot.org/uniprot/A0A2K5U9R6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/9541:FOXN3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CQQ7|||http://purl.uniprot.org/uniprot/A0A7N9D9G0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PPP2R5D ^@ http://purl.uniprot.org/uniprot/A0A2K5X0R2 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9541:HSDL1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YE60|||http://purl.uniprot.org/uniprot/G7PZV5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:ATP7B ^@ http://purl.uniprot.org/uniprot/A0A2K5TUF3 ^@ Subcellular Location Annotation ^@ trans-Golgi network membrane http://togogenome.org/gene/9541:GGH ^@ http://purl.uniprot.org/uniprot/A0A2K5UI25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C26 family.|||extracellular space http://togogenome.org/gene/9541:CBLB ^@ http://purl.uniprot.org/uniprot/A0A2K5UTD4|||http://purl.uniprot.org/uniprot/A0A2K5UTD7 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.|||The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. http://togogenome.org/gene/9541:CCL5 ^@ http://purl.uniprot.org/uniprot/G7PU47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:TAFA1 ^@ http://purl.uniprot.org/uniprot/I7GMV7 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9541:SGK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6V5|||http://purl.uniprot.org/uniprot/A0A2K5U6W3 ^@ Similarity ^@ Belongs to the protein kinase superfamily.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9541:SSBP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WW71|||http://purl.uniprot.org/uniprot/A0A2K5WWH4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FGF18 ^@ http://purl.uniprot.org/uniprot/A0A7N9IA32 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:EDEM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U245 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9541:TSPAN6 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y336|||http://purl.uniprot.org/uniprot/G7Q377 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:RBM4 ^@ http://purl.uniprot.org/uniprot/Q4R979 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Cytoplasmic granule|||Interacts with TNPO3; the interaction mediates nuclear import of the protein and is disrupted by nuclear Ran bound to GTP. Interacts with EIF4G1 and WT1. Interacts with EIF4A1; the interaction is modulated under stress-induced conditions. Interacts with AGO1. Interacts with AGO2; the interaction occurs under both cell proliferation and differentiation conditions and in an RNA- and phosphorylation-independent manner. Interacts with DDX5; the interaction occurs in an RNA-independent manner (By similarity).|||Nucleus|||Nucleus speckle|||Phosphorylated. Phosphorylated in vitro on Ser-309 by SRPK1. Phosphorylation on Ser-309 is induced upon cell stress signaling, which alters its subcellular localization and may modulate its activity on IRES-mediated mRNA translation. Phosphorylation on Ser-309 is induced upon cell muscle differentiation (By similarity).|||RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro (By similarity).|||nucleolus http://togogenome.org/gene/9541:FOXH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPR8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TBPL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUP4|||http://purl.uniprot.org/uniprot/G7PAC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/9541:CAPG ^@ http://purl.uniprot.org/uniprot/A0A2K5W9E6|||http://purl.uniprot.org/uniprot/G7PMM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the villin/gelsolin family.|||Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.|||Cytoplasm|||Melanosome|||Nucleus|||lamellipodium|||ruffle http://togogenome.org/gene/9541:MPZ ^@ http://purl.uniprot.org/uniprot/A0A2K5TVH9|||http://purl.uniprot.org/uniprot/G7NXB1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the myelin P0 protein family.|||Cell membrane|||Homodimer and homotetramer.|||Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.|||Membrane http://togogenome.org/gene/9541:LOC102137787 ^@ http://purl.uniprot.org/uniprot/G7NW93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TGFBR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WD61|||http://purl.uniprot.org/uniprot/A0A2K5WD91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Cell membrane|||Membrane|||Membrane raft|||Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. http://togogenome.org/gene/9541:FAM174C ^@ http://purl.uniprot.org/uniprot/A0A2K5VFT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/9541:USH2A ^@ http://purl.uniprot.org/uniprot/A0A2K5VJD4|||http://purl.uniprot.org/uniprot/A0A2K5VJI1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:MRRF ^@ http://purl.uniprot.org/uniprot/A0A2K5VLD5|||http://purl.uniprot.org/uniprot/A0A2K5VLI5 ^@ Function|||Similarity ^@ Belongs to the RRF family.|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/9541:CPOX ^@ http://purl.uniprot.org/uniprot/A0A2K5WTC0 ^@ Similarity|||Subunit ^@ Belongs to the aerobic coproporphyrinogen-III oxidase family.|||Homodimer. http://togogenome.org/gene/9541:SLC37A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U679 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.|||Membrane http://togogenome.org/gene/9541:PGBD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0M4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SAP18 ^@ http://purl.uniprot.org/uniprot/I7G2D2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SAP18 family.|||Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function.|||Cytoplasm|||Nucleus speckle http://togogenome.org/gene/9541:RBM17 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9A1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the spliceosome.|||Nucleus|||Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. http://togogenome.org/gene/9541:CDC26 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAK7|||http://purl.uniprot.org/uniprot/G7PRM8 ^@ Function|||Similarity ^@ Belongs to the CDC26 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. http://togogenome.org/gene/9541:FBXO32 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1L4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ADGRG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYF2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Membrane raft|||Secreted http://togogenome.org/gene/9541:HSD17B3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TM58 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:SLITRK5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPB5 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9541:RBP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W172 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Interacts with TTR.|||Retinol-binding protein that mediates retinol transport in blood plasma.|||Secreted http://togogenome.org/gene/9541:DAPK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULA9|||http://purl.uniprot.org/uniprot/G7P8U1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:EIF4G1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFL9|||http://purl.uniprot.org/uniprot/A0A2K5WFS2|||http://purl.uniprot.org/uniprot/A0A2K5WFX9|||http://purl.uniprot.org/uniprot/G7NYZ8 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4G family. http://togogenome.org/gene/9541:TRMT2A ^@ http://purl.uniprot.org/uniprot/A0A2K5WNL5 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:DIS3L ^@ http://purl.uniprot.org/uniprot/A0A2K5V9M4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNR ribonuclease family.|||Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms.|||Cytoplasm|||Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. http://togogenome.org/gene/9541:RBCK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYQ0|||http://purl.uniprot.org/uniprot/A0A2K5VYQ4 ^@ Similarity ^@ Belongs to the RBR family. http://togogenome.org/gene/9541:RTN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0A3|||http://purl.uniprot.org/uniprot/A0A2K5U0B4 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:SLC35C2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXX1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PITX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9541:MRPL36 ^@ http://purl.uniprot.org/uniprot/G8F2L2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/9541:HSPA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMB6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm|||Interacts with TJP1/ZO-1. http://togogenome.org/gene/9541:LOC102139145 ^@ http://purl.uniprot.org/uniprot/A0A2K5UK15 ^@ Function|||Similarity ^@ Belongs to the SAA family.|||Major acute phase reactant. Apolipoprotein of the HDL complex. http://togogenome.org/gene/9541:TASOR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7Q8 ^@ Similarity ^@ Belongs to the TASOR family. http://togogenome.org/gene/9541:CRYBG3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRQ9 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9541:KDM1A ^@ http://purl.uniprot.org/uniprot/A0A2K5TKW6|||http://purl.uniprot.org/uniprot/A0A2K5TKZ2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the flavin monoamine oxidase family.|||Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.|||Nucleus|||The SWIRM domain may act as an anchor site for a histone tail. http://togogenome.org/gene/9541:GPR137B ^@ http://purl.uniprot.org/uniprot/A0A2K5UBH1 ^@ Subcellular Location Annotation ^@ Lysosome membrane|||Membrane http://togogenome.org/gene/9541:DLX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRP7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:GK5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TT23|||http://purl.uniprot.org/uniprot/A0A7N9IBB2 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/9541:GTF2E2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTQ5|||http://purl.uniprot.org/uniprot/G7PD55 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIE beta subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.|||Tetramer of two alpha and two beta chains. http://togogenome.org/gene/9541:ACAD9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRB8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9541:VENTX ^@ http://purl.uniprot.org/uniprot/A0A2K5UA13 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CXCL1 ^@ http://purl.uniprot.org/uniprot/Q0EAC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9541:SLCO2A1 ^@ http://purl.uniprot.org/uniprot/Q4R830 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:OSBPL5 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8V6 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9541:COG7 ^@ http://purl.uniprot.org/uniprot/A0A8J8XHI7|||http://purl.uniprot.org/uniprot/G7Q0Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG7 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:ALKBH8 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8D0|||http://purl.uniprot.org/uniprot/Q95K79 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alkB family.|||Binds 1 Fe(2+) ion per subunit.|||Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis (By similarity).|||Cytoplasm|||Interacts with TRMT112.|||Nucleus http://togogenome.org/gene/9541:LHFPL4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7P4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ISL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3G6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PDC ^@ http://purl.uniprot.org/uniprot/A0A2K5U750|||http://purl.uniprot.org/uniprot/G7NXE9 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9541:CDH18 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPM6 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:RABEP2 ^@ http://purl.uniprot.org/uniprot/Q4R6D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rabaptin family.|||Early endosome|||Endosome|||centrosome|||cilium basal body http://togogenome.org/gene/9541:PVALB ^@ http://purl.uniprot.org/uniprot/A0A2K5VH89|||http://purl.uniprot.org/uniprot/G7PFB9 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/9541:OXT ^@ http://purl.uniprot.org/uniprot/I7G319 ^@ Similarity ^@ Belongs to the vasopressin/oxytocin family. http://togogenome.org/gene/9541:XPO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNY6|||http://purl.uniprot.org/uniprot/A0A7N9CMG1|||http://purl.uniprot.org/uniprot/G7PMA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm http://togogenome.org/gene/9541:ZC3H12A ^@ http://purl.uniprot.org/uniprot/A0A2K5V3E9 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/9541:TMTC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJL1|||http://purl.uniprot.org/uniprot/A0A2K5VJM6|||http://purl.uniprot.org/uniprot/A0A7N9DB79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9541:ABCG8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTH8|||http://purl.uniprot.org/uniprot/G7PM41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9541:ALX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X833 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ATP8B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U251 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9541:CPPED1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4Y7 ^@ Function|||Similarity ^@ Belongs to the metallophosphoesterase superfamily. CPPED1 family.|||Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes. http://togogenome.org/gene/9541:MIOS ^@ http://purl.uniprot.org/uniprot/A0A2K5WH75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat mio family.|||Lysosome membrane http://togogenome.org/gene/9541:SDHC ^@ http://purl.uniprot.org/uniprot/A0A2K5VYJ1|||http://purl.uniprot.org/uniprot/A0A2K5VYL2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b560 family.|||Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). http://togogenome.org/gene/9541:ANP32A ^@ http://purl.uniprot.org/uniprot/I7GHD6 ^@ Similarity ^@ Belongs to the ANP32 family. http://togogenome.org/gene/9541:RNASEK ^@ http://purl.uniprot.org/uniprot/I7GKE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase K family.|||Membrane http://togogenome.org/gene/9541:ODF2L ^@ http://purl.uniprot.org/uniprot/A0A2K5UGW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||centrosome http://togogenome.org/gene/9541:MRPL14 ^@ http://purl.uniprot.org/uniprot/G7P402 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/9541:CKB ^@ http://purl.uniprot.org/uniprot/A0A2K5WBF5 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9541:BMPR1B ^@ http://purl.uniprot.org/uniprot/A0A2K5W4N9|||http://purl.uniprot.org/uniprot/A0A2K5W4R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9541:LOC102126703 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-defensin family.|||Secreted http://togogenome.org/gene/9541:USP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4E6|||http://purl.uniprot.org/uniprot/A0A8J8XDN1|||http://purl.uniprot.org/uniprot/G7PPB3 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9541:TBL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQ25 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9541:MAPRE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8Q4|||http://purl.uniprot.org/uniprot/A0A2K5X8R3|||http://purl.uniprot.org/uniprot/A0A2K5X8U5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.|||cytoskeleton http://togogenome.org/gene/9541:CCNJL ^@ http://purl.uniprot.org/uniprot/A0A2K5TXX7|||http://purl.uniprot.org/uniprot/A0A2K5TXX8 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9541:LOC102128296 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBG0|||http://purl.uniprot.org/uniprot/A0A2K5UH45 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/9541:PALM2AKAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UC33 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/9541:CD151 ^@ http://purl.uniprot.org/uniprot/A0A2K5WB08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:POLR2M ^@ http://purl.uniprot.org/uniprot/A0A2K5V9H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRINL1 family.|||Nucleus http://togogenome.org/gene/9541:CFL1 ^@ http://purl.uniprot.org/uniprot/Q4R5C0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin-binding proteins ADF family.|||Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (By similarity). Important for normal progress through mitosis and normal cytokinesis (By similarity). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). Required for neural tube morphogenesis and neural crest cell migration (By similarity).|||Can bind G- and F-actin in a 1:1 ratio of cofilin to actin (By similarity). It is a major component of intranuclear and cytoplasmic actin rods (By similarity). Interacts with the subcortical maternal complex (SCMC) via interaction with TLE6 and NLRP5 (By similarity). Interacts with C9orf72 (By similarity).|||Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells (By similarity). Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal (By similarity). Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor ACKR2 (By similarity).|||Nucleus matrix|||axon|||cytoskeleton|||growth cone|||lamellipodium|||lamellipodium membrane|||ruffle membrane http://togogenome.org/gene/9541:LOC102139623 ^@ http://purl.uniprot.org/uniprot/A0A2K5VL90 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9541:ILK ^@ http://purl.uniprot.org/uniprot/A0A2K5WGD3|||http://purl.uniprot.org/uniprot/A0A2K5WGG1|||http://purl.uniprot.org/uniprot/G7PQV1 ^@ Subcellular Location Annotation ^@ focal adhesion|||lamellipodium|||sarcomere http://togogenome.org/gene/9541:PNLDC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVD2 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/9541:COPZ1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V909|||http://purl.uniprot.org/uniprot/A0A7N9CQ73|||http://purl.uniprot.org/uniprot/G8F5B8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes small subunit family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. http://togogenome.org/gene/9541:SCML2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/9541:SNRPB ^@ http://purl.uniprot.org/uniprot/A0A2K5WP22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP SmB/SmN family.|||Nucleus http://togogenome.org/gene/9541:RHCG ^@ http://purl.uniprot.org/uniprot/A0A8J8XKZ0|||http://purl.uniprot.org/uniprot/G7P9E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9541:MRPL40 ^@ http://purl.uniprot.org/uniprot/A0A8J8YSK4|||http://purl.uniprot.org/uniprot/G7PH82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL40 family.|||Mitochondrion http://togogenome.org/gene/9541:TSPAN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ83|||http://purl.uniprot.org/uniprot/A0A2K5UZ94 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:FABP4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YKQ0|||http://purl.uniprot.org/uniprot/G7PC40 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:SSBP1 ^@ http://purl.uniprot.org/uniprot/A0A7N9C9N4|||http://purl.uniprot.org/uniprot/A0A8J8XDD0|||http://purl.uniprot.org/uniprot/G7P1E9 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/9541:TTC39B ^@ http://purl.uniprot.org/uniprot/A0A2K5TYU0|||http://purl.uniprot.org/uniprot/A0A2K5TYV0|||http://purl.uniprot.org/uniprot/Q95LT8 ^@ Function|||Similarity ^@ Belongs to the TTC39 family.|||Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3). http://togogenome.org/gene/9541:PAQR8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UC52|||http://purl.uniprot.org/uniprot/G7P4V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9541:MAP4K2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBY9 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. http://togogenome.org/gene/9541:PLXNA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVJ0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:SPTBN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2X6 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/9541:LOC101925219 ^@ http://purl.uniprot.org/uniprot/A0A2K5VS48|||http://purl.uniprot.org/uniprot/A0A2K5VS77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCAF family.|||Nucleus http://togogenome.org/gene/9541:RPL10 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDM4|||http://purl.uniprot.org/uniprot/G7Q3B3|||http://purl.uniprot.org/uniprot/Q4R7Y2 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Citrullinated by PADI4.|||Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).|||Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.|||Ufmylated by UFL1. http://togogenome.org/gene/9541:FOXI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFG3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CBFA2T2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9Z9 ^@ Similarity ^@ Belongs to the CBFA2T family. http://togogenome.org/gene/9541:HMCES ^@ http://purl.uniprot.org/uniprot/A0A2K5V147 ^@ Function|||Similarity ^@ Belongs to the SOS response-associated peptidase family.|||Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction. http://togogenome.org/gene/9541:ENO3 ^@ http://purl.uniprot.org/uniprot/A0A2K5URN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9541:COQ8A ^@ http://purl.uniprot.org/uniprot/A0A2K5VRC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Membrane|||Mitochondrion http://togogenome.org/gene/9541:ZHX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIR8|||http://purl.uniprot.org/uniprot/G7PCR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/9541:ABITRAM ^@ http://purl.uniprot.org/uniprot/A0A2K5W2H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABITRAM family.|||growth cone|||lamellipodium http://togogenome.org/gene/9541:TTYH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUE6|||http://purl.uniprot.org/uniprot/A0A2K5UUF4|||http://purl.uniprot.org/uniprot/Q9MZZ8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tweety family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Probable chloride channel.|||Probable chloride channel. May be involved in cell adhesion (By similarity). http://togogenome.org/gene/9541:LOC102130495 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAW2|||http://purl.uniprot.org/uniprot/G7P5Z7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:PDSS2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XRJ7|||http://purl.uniprot.org/uniprot/G7P454 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9541:RPL35A ^@ http://purl.uniprot.org/uniprot/G8F3S7|||http://purl.uniprot.org/uniprot/P61272 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL33 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for the proliferation and viability of hematopoietic cells.|||Cytoplasm http://togogenome.org/gene/9541:TATDN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TT38|||http://purl.uniprot.org/uniprot/A0A2K5TT59 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/9541:DDX1 ^@ http://purl.uniprot.org/uniprot/Q4R7L5 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity).|||Belongs to the DEAD box helicase family. DDX1 subfamily.|||Cytoplasm|||Cytoplasmic granule|||Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1; this complex exists in resting cells with or without poly(I:C) RNA ligand stimulation (By similarity). Interacts with DHX36 (By similarity). Interacts (via B30.2/SPRY domain) with DDX21 (via N-terminus); this interaction serves as bridges to TICAM1 (By similarity). Interacts with FAM98A (via N- and C-terminus) (By similarity). Interacts with PHF5A (via C-terminus) (By similarity). Interacts with MBNL1 (By similarity). Interacts with CSTF2 (By similarity). Interacts with HNRNPK (By similarity). Interacts with ATM (By similarity). Interacts with RELA (via C-terminus) (By similarity). Component of the tRNA-splicing ligase complex (By similarity). Interacts with PQBP1 (By similarity). Interacts with ERCC6 (By similarity).|||Mitochondrion|||Nucleus|||Phosphorylated by ATM kinase; phosphorylation is increased in response to ionizing radiation (IR).|||The helicase domain is involved in the stimulation of RELA transcriptional activity.|||cytosol http://togogenome.org/gene/9541:EPHA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU29 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102146205 ^@ http://purl.uniprot.org/uniprot/A0A088G4T6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:ZP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9W9|||http://purl.uniprot.org/uniprot/Q861S0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZP domain family. ZPB subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Zona pellucida http://togogenome.org/gene/9541:SIKE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V835|||http://purl.uniprot.org/uniprot/A0A7N9CJ40 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/9541:CRMP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6Z7|||http://purl.uniprot.org/uniprot/A0A2K5X7G4 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9541:SYNM ^@ http://purl.uniprot.org/uniprot/A0A2K5U4W1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:LOC102140349 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJ62 ^@ Similarity ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. http://togogenome.org/gene/9541:PEX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VU68|||http://purl.uniprot.org/uniprot/A0A2K5VU93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm http://togogenome.org/gene/9541:CFAP43 ^@ http://purl.uniprot.org/uniprot/A0A2K5VH82 ^@ Similarity ^@ Belongs to the CFAP43 family. http://togogenome.org/gene/9541:SEMA3C ^@ http://purl.uniprot.org/uniprot/A0A2K5X715 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:ST8SIA5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBL0|||http://purl.uniprot.org/uniprot/A0A2K5VBP9|||http://purl.uniprot.org/uniprot/A0A2K5VBQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:ETV3L ^@ http://purl.uniprot.org/uniprot/A0A2K5TRN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:SEPTIN12 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ77|||http://purl.uniprot.org/uniprot/A0A8J8YJG8|||http://purl.uniprot.org/uniprot/G7Q0E9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9541:SCG2 ^@ http://purl.uniprot.org/uniprot/Q4R5E9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chromogranin/secretogranin protein family.|||Binds calcium with a low-affinity.|||Interacts with Secretogranin III/SCG3.|||Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.|||Secreted http://togogenome.org/gene/9541:SLC39A14 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9K8|||http://purl.uniprot.org/uniprot/A0A2K5W9L7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PROZ ^@ http://purl.uniprot.org/uniprot/A0A2K5VZQ1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:NSG1 ^@ http://purl.uniprot.org/uniprot/Q4R5Q3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSG family.|||Cytoplasmic vesicle membrane|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Forms a complex with GRIP1, GRIA2 and STX12 through direct interaction with GRIP1; controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. Interacts with STX12 (By similarity). Interacts with APP; could regulate APP processing (By similarity). Interacts with FAM171A1 (By similarity).|||Golgi stack membrane|||Late endosome membrane|||Lysosome lumen|||Membrane|||Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (By similarity).|||Recycling endosome membrane|||dendrite|||multivesicular body membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:NME6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2N1|||http://purl.uniprot.org/uniprot/G8F304|||http://purl.uniprot.org/uniprot/I7GCU7 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9541:ORMDL3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XRK2|||http://purl.uniprot.org/uniprot/G7PUM9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORM family.|||Endoplasmic reticulum membrane|||Interacts with SPTLC1.|||Membrane|||Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling. http://togogenome.org/gene/9541:MYO10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRV0 ^@ Caution|||Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ARL3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CAA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/9541:ESRP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWK5|||http://purl.uniprot.org/uniprot/A0A2K5UWL1|||http://purl.uniprot.org/uniprot/A0A2K5UWQ8|||http://purl.uniprot.org/uniprot/G7PC86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESRP family.|||Nucleus http://togogenome.org/gene/9541:CCN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULD7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:B3GAT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:ADAMTS16 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8E2 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:SYCP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SYCP2 family.|||Nucleus http://togogenome.org/gene/9541:LOC102131151 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAI4 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9541:CYP2B6 ^@ http://purl.uniprot.org/uniprot/B8K1S9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:PPP1R1A ^@ http://purl.uniprot.org/uniprot/I7G6I7 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/9541:CXXC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNU8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:APOBEC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNN4|||http://purl.uniprot.org/uniprot/G7P3F1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:SEC31A ^@ http://purl.uniprot.org/uniprot/A0A2K5TTM3|||http://purl.uniprot.org/uniprot/A0A2K5TTM4|||http://purl.uniprot.org/uniprot/A0A2K5TTM7|||http://purl.uniprot.org/uniprot/A0A2K5TTN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC31 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:LOC102115085 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAP9|||http://purl.uniprot.org/uniprot/G7P1J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:RNF10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNF10 family.|||Cytoplasm http://togogenome.org/gene/9541:DMAC2L ^@ http://purl.uniprot.org/uniprot/A0A2K5VY90|||http://purl.uniprot.org/uniprot/A0A7N9CIX1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATP synthase subunit s family.|||Homotetramer. Associates with ATP synthase.|||Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:AQP8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9541:PHKB ^@ http://purl.uniprot.org/uniprot/A0A2K5VG98|||http://purl.uniprot.org/uniprot/A0A2K5VGD8|||http://purl.uniprot.org/uniprot/G7Q125 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. http://togogenome.org/gene/9541:ADGRG6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7W4|||http://purl.uniprot.org/uniprot/A0A2K5U7W9|||http://purl.uniprot.org/uniprot/A0A2K5U7X0|||http://purl.uniprot.org/uniprot/A0A2K5U820 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:ARAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WW63|||http://purl.uniprot.org/uniprot/A0A2K5WWF2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:LOC102117012 ^@ http://purl.uniprot.org/uniprot/A0A7N9D238 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:CAPN5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDC5 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9541:LOC102116883 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGQ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ACO2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHM1|||http://purl.uniprot.org/uniprot/A0A7N9D0G3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.|||Mitochondrion http://togogenome.org/gene/9541:BRINP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQM2 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9541:PUS10 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8M0 ^@ Similarity ^@ Belongs to the pseudouridine synthase Pus10 family. http://togogenome.org/gene/9541:VIPAS39 ^@ http://purl.uniprot.org/uniprot/G7PB33 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome|||Late endosome|||Vesicle http://togogenome.org/gene/9541:RNF32 ^@ http://purl.uniprot.org/uniprot/Q4R5T4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May play a role in sperm formation. http://togogenome.org/gene/9541:DCAF11 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGV9|||http://purl.uniprot.org/uniprot/A0A2K5UGW1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat LEC14B family.|||Interacts with DDB1 and CUL4A.|||May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. http://togogenome.org/gene/9541:HHATL ^@ http://purl.uniprot.org/uniprot/A0A8J8YIJ7|||http://purl.uniprot.org/uniprot/G7NY66 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CDPF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQT7 ^@ Similarity ^@ Belongs to the CDPF1 family. http://togogenome.org/gene/9541:SERF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR10 ^@ Similarity ^@ Belongs to the SERF family. http://togogenome.org/gene/9541:SPO11 ^@ http://purl.uniprot.org/uniprot/A0A2K5UV77 ^@ Similarity ^@ Belongs to the TOP6A family. http://togogenome.org/gene/9541:SERPINB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAJ6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:TOR1B ^@ http://purl.uniprot.org/uniprot/A0A2K5WSY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9541:MYO1A ^@ http://purl.uniprot.org/uniprot/A0A2K5VMC9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:HIP1R ^@ http://purl.uniprot.org/uniprot/A0A2K5WTP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLA2 family.|||Membrane http://togogenome.org/gene/9541:GTF3C5 ^@ http://purl.uniprot.org/uniprot/Q4R835 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:HMBOX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9Z2|||http://purl.uniprot.org/uniprot/A0A2K5V9Z7|||http://purl.uniprot.org/uniprot/A0A7N9CEA4|||http://purl.uniprot.org/uniprot/A0A7N9D4V8|||http://purl.uniprot.org/uniprot/G7PD48 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SSU72 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3K9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSU72 phosphatase family.|||Nucleus|||Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. http://togogenome.org/gene/9541:SLC39A13 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9X4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PCNX4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2Y0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:MINDY2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6J1 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/9541:WFIKKN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVF3 ^@ Similarity ^@ Belongs to the WFIKKN family. http://togogenome.org/gene/9541:LOC101867156 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0M7|||http://purl.uniprot.org/uniprot/A0A8J8XCF7|||http://purl.uniprot.org/uniprot/G7P9V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:INPP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZL8|||http://purl.uniprot.org/uniprot/G7PL18 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9541:KCND1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZL1|||http://purl.uniprot.org/uniprot/G7Q2P3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||dendrite http://togogenome.org/gene/9541:POGLUT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRS9 ^@ Similarity ^@ Belongs to the KDELC family. http://togogenome.org/gene/9541:DNAH9 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1E2 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/9541:LGALS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U233 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9541:CADM3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJL5 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9541:FSCN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W420 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/9541:IL1A ^@ http://purl.uniprot.org/uniprot/Q4R4F0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||Cytoplasm|||Monomer.|||Nucleus|||Secreted http://togogenome.org/gene/9541:TMEFF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWD7|||http://purl.uniprot.org/uniprot/G7PL27 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC102119473 ^@ http://purl.uniprot.org/uniprot/A0A2K5WI75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane|||synaptic vesicle membrane|||synaptosome http://togogenome.org/gene/9541:ACP2 ^@ http://purl.uniprot.org/uniprot/Q4R5N9 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family.|||Lysosome lumen|||Lysosome membrane|||The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen (By similarity). http://togogenome.org/gene/9541:GALNS ^@ http://purl.uniprot.org/uniprot/A0A2K5VWH7 ^@ PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sulfatase family.|||Homodimer.|||Lysosome|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9541:GART ^@ http://purl.uniprot.org/uniprot/A0A2K5WK72 ^@ Similarity ^@ In the C-terminal section; belongs to the GART family.|||In the N-terminal section; belongs to the GARS family.|||In the central section; belongs to the AIR synthase family. http://togogenome.org/gene/9541:FAM151A ^@ http://purl.uniprot.org/uniprot/A0A2K5TS87 ^@ Similarity ^@ Belongs to the FAM151 family. http://togogenome.org/gene/9541:FERMT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEF8 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/9541:C1GALT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWB6|||http://purl.uniprot.org/uniprot/A0A2K5UWK3|||http://purl.uniprot.org/uniprot/A0A7N9CVW8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.|||Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.|||Membrane http://togogenome.org/gene/9541:TSEN54 ^@ http://purl.uniprot.org/uniprot/A0A2K5X978 ^@ Similarity ^@ Belongs to the SEN54 family. http://togogenome.org/gene/9541:AKR1C1 ^@ http://purl.uniprot.org/uniprot/I7G981 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family.|||Monomer. http://togogenome.org/gene/9541:MRPL10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPN5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/9541:RUNX1T1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2S4|||http://purl.uniprot.org/uniprot/A0A2K5V2T1|||http://purl.uniprot.org/uniprot/G7PC74|||http://purl.uniprot.org/uniprot/Q2PG35 ^@ Similarity ^@ Belongs to the CBFA2T family. http://togogenome.org/gene/9541:MCOLN1 ^@ http://purl.uniprot.org/uniprot/Q60HE8 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN1 sub-subfamily.|||Cell membrane|||Channel activity is controlled by multiple regulatory mechanisms in different subcellular compartments. Channel function is transiently modulated by changes in Ca(2+), and inhibited by a reduction of pH; pH changes modify the aggregation state of unitary channels; a negative cooperativity between extracellular/lumenal Ca(2+) and H(+) is suggested. Regulated by phosphoinositides in a compartment-specific manner: in lysosomes activated by PtdIns(3,5)P2 (Phosphatidylinositol 3,5-bisphosphate) and at the plasma membrane inhibited by PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate).|||Cytoplasmic vesicle membrane|||Homotetramer. Homooligomer. Can heterooligomerize with MCOLN2 or MCOLN3; heteromeric assemblies have different channel properties as compared to the respective homooligomers and may be tissue-specific. Interacts with PDCD6. Interacts with TMEM163. Interacts with LAPTM4B.|||Late endosome membrane|||Lysosome membrane|||May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates the activity of an associated phospholipase.|||Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy. Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion. Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events. By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels. Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy. Functions as a Fe(2+) permeable channel in late endosomes and lysosomes. Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells.|||Palmitoylated; involved in association with membranes.|||Phosphorylation by PKA inhibits channel activity. Dephosphorylation increases activity.|||Proteolytically cleaved probably involving multiple lysosomal proteases including cathepsin B; inhibits lysosomal channel activity.|||The most N-terminal extracellular/lumenal domain (referred to as I-II linker or polycystin-mucolipin domain) contributes to a structure with a four-fold rotational symmetry in a tetrameric assembly; the structure contains a central highly electronegative pore with a 14 A diameter. The pore is critical for Ca(2+) and pH regulation. The protruding structure formed by the I-II linkers may contain all the interaction sites with lipids and proteins in the endolysosomal lumen.|||phagocytic cup|||phagosome membrane http://togogenome.org/gene/9541:CHAC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHG6 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/9541:TIMM17B ^@ http://purl.uniprot.org/uniprot/A0A2K5UAM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:DLX1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YK27|||http://purl.uniprot.org/uniprot/G7PKU0|||http://purl.uniprot.org/uniprot/I7GIQ8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102129793 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0U2|||http://purl.uniprot.org/uniprot/A0A2K5W142|||http://purl.uniprot.org/uniprot/G7P1S4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the zona pellucida-binding protein Sp38 family.|||Secreted http://togogenome.org/gene/9541:EGFLAM ^@ http://purl.uniprot.org/uniprot/A0A2K5TUL9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:MEA1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CLZ5|||http://purl.uniprot.org/uniprot/A0A8J8Y7N4|||http://purl.uniprot.org/uniprot/G7P3Y9|||http://purl.uniprot.org/uniprot/Q4R992 ^@ Caution|||Function ^@ It is uncertain whether Met-1 or Met-11 is the initiator.|||May play an important role in spermatogenesis and/or testis development. http://togogenome.org/gene/9541:LOC101866469 ^@ http://purl.uniprot.org/uniprot/G7P578 ^@ Similarity ^@ Belongs to the MORF4 family-associated protein family. http://togogenome.org/gene/9541:CA14 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRM8 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/9541:CFAP97 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDK2|||http://purl.uniprot.org/uniprot/A0A2K5UDP0 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/9541:WNT2B ^@ http://purl.uniprot.org/uniprot/A0A2K5TYW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:CYP2A13 ^@ http://purl.uniprot.org/uniprot/A0A2K5V274 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:CDC73 ^@ http://purl.uniprot.org/uniprot/A0A8J8YD42|||http://purl.uniprot.org/uniprot/G7NXD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC73 family.|||Nucleus http://togogenome.org/gene/9541:MRGPRD ^@ http://purl.uniprot.org/uniprot/A0A7N9CGP4 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:ZSCAN29 ^@ http://purl.uniprot.org/uniprot/A0A2K5X625 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:AASDH ^@ http://purl.uniprot.org/uniprot/A0A2K5V8Q1|||http://purl.uniprot.org/uniprot/A0A7N9CGA7 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9541:ISCA2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CFA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/9541:RPS6KA6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U185|||http://purl.uniprot.org/uniprot/A0A2K5U1B3|||http://purl.uniprot.org/uniprot/A0A2K5U1F5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9541:PPP2CB ^@ http://purl.uniprot.org/uniprot/A0A2K5X5X2 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/9541:CCKAR ^@ http://purl.uniprot.org/uniprot/A0A2K5WAE8|||http://purl.uniprot.org/uniprot/G7P5D4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9541:PIPOX ^@ http://purl.uniprot.org/uniprot/A0A2K5UKU2|||http://purl.uniprot.org/uniprot/A0A7N9CUM7|||http://purl.uniprot.org/uniprot/G8F5H8 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/9541:LOC102144964 ^@ http://purl.uniprot.org/uniprot/A0A8J8XVN4|||http://purl.uniprot.org/uniprot/G7NTR7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:SMUG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.|||Nucleus http://togogenome.org/gene/9541:SLC28A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/9541:RAB4B ^@ http://purl.uniprot.org/uniprot/A0A2K5V7T2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. http://togogenome.org/gene/9541:GPM6B ^@ http://purl.uniprot.org/uniprot/A0A2K5WHV9|||http://purl.uniprot.org/uniprot/A0A2K5WHX3|||http://purl.uniprot.org/uniprot/G7Q290 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9541:RAP1B ^@ http://purl.uniprot.org/uniprot/Q4R9D4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner.|||Belongs to the small GTPase superfamily. Ras family.|||Cell junction|||Cell membrane|||GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity).|||Heterodimer with RAP1GAP (By similarity). Interacts with EPAC2 (By similarity). Interacts with SGSM1 (By similarity). Interacts with SGSM2 (By similarity). Interacts with SGSM3 (By similarity). Interacts with KRIT1 (By similarity). Interacts with RAP1GDS1 (By similarity).|||cytosol http://togogenome.org/gene/9541:LCE5A ^@ http://purl.uniprot.org/uniprot/A0A2K5UNK6|||http://purl.uniprot.org/uniprot/G8F3E4 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9541:TMEM198 ^@ http://purl.uniprot.org/uniprot/I7GF23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane http://togogenome.org/gene/9541:CNEP1R1 ^@ http://purl.uniprot.org/uniprot/A0A7N9D9L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNEP1R1 family.|||Cytoplasm|||Membrane|||Nucleus membrane http://togogenome.org/gene/9541:GGT7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WT09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyltransferase family.|||Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.|||Membrane http://togogenome.org/gene/9541:SAMHD1 ^@ http://purl.uniprot.org/uniprot/K4JU89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAMHD1 family.|||Chromosome http://togogenome.org/gene/9541:PCYT1B ^@ http://purl.uniprot.org/uniprot/A0A2K5U167 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/9541:TSPYL2 ^@ http://purl.uniprot.org/uniprot/Q9BE64 ^@ Function|||Induction|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the nucleosome assembly protein (NAP) family.|||By TGFB1 and all-trans retinoic acid in lung cells (at protein level).|||Cytoplasm|||Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TBR1 and TSPYL2 (By similarity).|||Nucleus|||Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression (By similarity).|||Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation.|||Subject to X inactivation.|||Synaptic activity down-regulates TSPYL2 protein levels by inducing rapid proteasomal degradation.|||Ubiquitously expressed, with highest levels in testis, adrenal gland, cerebral cortex, ovary, skeletal muscle and spleen. Present in testis, adrenal gland, cerebral cortex and ovary (at protein level). http://togogenome.org/gene/9541:REXO2 ^@ http://purl.uniprot.org/uniprot/G7PP03 ^@ Similarity ^@ Belongs to the oligoribonuclease family. http://togogenome.org/gene/9541:TMEM161B ^@ http://purl.uniprot.org/uniprot/A0A2K5VDR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM161 family.|||Membrane http://togogenome.org/gene/9541:LOC102136480 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTT8|||http://purl.uniprot.org/uniprot/A0A2K5VTY6 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/9541:LOC102122430 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR05 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:SPATA16 ^@ http://purl.uniprot.org/uniprot/Q4R3V2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPATA16 family.|||Essential for spermiogenesis and male fertility (By similarity). Involved in the formation of sperm acrosome during spermatogenesis (By similarity).|||Golgi apparatus|||acrosome http://togogenome.org/gene/9541:SERPINB10 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9V3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:ZCCHC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZCCHC4 family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9541:INSM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEF6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:IHH ^@ http://purl.uniprot.org/uniprot/A0A2K5TS65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XLF subfamily.|||Nucleus http://togogenome.org/gene/9541:LOC101926212 ^@ http://purl.uniprot.org/uniprot/A0A7N9D6B3|||http://purl.uniprot.org/uniprot/Q4R7K2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC101926462 ^@ http://purl.uniprot.org/uniprot/A0A2K5TL41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/9541:ZNF449 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPM8|||http://purl.uniprot.org/uniprot/A0A8J8XYN0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:RAPSN ^@ http://purl.uniprot.org/uniprot/A0A2K5WJX9 ^@ Similarity ^@ Belongs to the RAPsyn family. http://togogenome.org/gene/9541:LOC102137836 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lambda interferon family.|||Secreted http://togogenome.org/gene/9541:CDH13 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8H7|||http://purl.uniprot.org/uniprot/A0A2K5W8I7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.|||Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CSGALNACT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9541:LPIN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VB78|||http://purl.uniprot.org/uniprot/A0A2K5VB83|||http://purl.uniprot.org/uniprot/A0A2K5VBA0|||http://purl.uniprot.org/uniprot/A0A2K5VBB5|||http://purl.uniprot.org/uniprot/A0A7N9D8W5 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/9541:ACTN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVV0|||http://purl.uniprot.org/uniprot/A0A2K5VVZ5 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9541:BTC ^@ http://purl.uniprot.org/uniprot/A0A2K5X5E5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:FOXI3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZU5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ODAM ^@ http://purl.uniprot.org/uniprot/A0A2K5VPB9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ODAM family.|||Cytoplasm|||Interacts (via C-terminus) with ARHGEF5.|||Nucleus|||Secreted|||Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface. http://togogenome.org/gene/9541:VPS36 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ22|||http://purl.uniprot.org/uniprot/A0A2K5VZ38 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS36 family.|||Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II).|||Cytoplasm|||Endosome http://togogenome.org/gene/9541:USP14 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7K2|||http://purl.uniprot.org/uniprot/A0A2K5U7L4|||http://purl.uniprot.org/uniprot/A0A7N9CZD4|||http://purl.uniprot.org/uniprot/I7GI76 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase C19 family.|||Belongs to the peptidase C19 family. USP14/UBP6 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS. http://togogenome.org/gene/9541:ADAMDEC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDE7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:DHCR7 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7E1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/9541:TPI1 ^@ http://purl.uniprot.org/uniprot/Q60HC9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.|||Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. http://togogenome.org/gene/9541:CPE ^@ http://purl.uniprot.org/uniprot/Q4R4M3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M14 family.|||Binds 1 zinc ion per subunit.|||Interacts with secretogranin III/SCG3.|||Secreted|||Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.|||secretory vesicle|||secretory vesicle membrane http://togogenome.org/gene/9541:RBP7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNM0 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:ZSCAN22 ^@ http://purl.uniprot.org/uniprot/A0A2K5WM71 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CHD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAF0|||http://purl.uniprot.org/uniprot/A0A7N9IG37 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102146459 ^@ http://purl.uniprot.org/uniprot/A0A8J8YEU4|||http://purl.uniprot.org/uniprot/G7Q3I7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family.|||Homotrimer.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/9541:ATRN ^@ http://purl.uniprot.org/uniprot/A0A2K5U1W6|||http://purl.uniprot.org/uniprot/A0A2K5U1W7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:CALCA ^@ http://purl.uniprot.org/uniprot/A0A2K5VW68 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/9541:LOC102140170 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3A8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the misato family.|||Mitochondrion outer membrane http://togogenome.org/gene/9541:CMTM8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTJ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102137606 ^@ http://purl.uniprot.org/uniprot/A0A2K5WP89|||http://purl.uniprot.org/uniprot/A0A2K5WPA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9541:MMP12 ^@ http://purl.uniprot.org/uniprot/A0A8J8YBR3|||http://purl.uniprot.org/uniprot/G7PNK7 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9541:PIK3C3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEV7|||http://purl.uniprot.org/uniprot/A0A2K5WF49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.|||Midbody http://togogenome.org/gene/9541:RAB3C ^@ http://purl.uniprot.org/uniprot/A0A7N9CIY2|||http://purl.uniprot.org/uniprot/A0A8J8XFS3|||http://purl.uniprot.org/uniprot/G7P7K2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9541:TRIM23 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6K7|||http://purl.uniprot.org/uniprot/G7P7M3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:GABARAPL2 ^@ http://purl.uniprot.org/uniprot/I7GJ90 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9541:RNF126 ^@ http://purl.uniprot.org/uniprot/A0A2K5U781 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:SIX4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWJ2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TNIP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAV3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:UGT3A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFP5|||http://purl.uniprot.org/uniprot/A0A7G0UDE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9541:PKP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WB38 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9541:FCN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5Q9 ^@ Similarity ^@ Belongs to the ficolin lectin family. http://togogenome.org/gene/9541:EBF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V061 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/9541:CERCAM ^@ http://purl.uniprot.org/uniprot/A0A2K5TVP7 ^@ Similarity ^@ Belongs to the glycosyltransferase 25 family. http://togogenome.org/gene/9541:LOC102133014 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8U4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.|||Belongs to the osteocalcin/matrix Gla protein family.|||Requires vitamin K-dependent gamma-carboxylation for its function.|||Secreted http://togogenome.org/gene/9541:GPX8 ^@ http://purl.uniprot.org/uniprot/A0A7N9CZP0|||http://purl.uniprot.org/uniprot/G7P7I5 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9541:GTPBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMJ7 ^@ Function ^@ Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity. http://togogenome.org/gene/9541:HOXB1 ^@ http://purl.uniprot.org/uniprot/A0A7N9D9U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9541:HINT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TM01 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/9541:G2E3 ^@ http://purl.uniprot.org/uniprot/Q4R9C4 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.|||Ubiquitin ligase activity is mediated by two distinct domains, PHD-type zinc fingers 2 and 3. The use of these distinct domains may allow ubiquitination of different targets by each domain. The HECT domain is catalytically inactive and does not contribute to this activity.|||nucleolus http://togogenome.org/gene/9541:TCAF1 ^@ http://purl.uniprot.org/uniprot/G8F2M5 ^@ Similarity ^@ Belongs to the TCAF family. http://togogenome.org/gene/9541:MUS81 ^@ http://purl.uniprot.org/uniprot/A0A2K5U706 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPF family.|||Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).|||Interacts with EME1.|||Nucleus http://togogenome.org/gene/9541:BCAR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLU8|||http://purl.uniprot.org/uniprot/A0A2K5TLV1|||http://purl.uniprot.org/uniprot/A0A2K5TLV2|||http://purl.uniprot.org/uniprot/A0A2K5TLV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/9541:SLC43A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WV66 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GRIN2C ^@ http://purl.uniprot.org/uniprot/A0A2K5VRU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9541:RNASE6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCI8 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9541:VDR ^@ http://purl.uniprot.org/uniprot/A0A2K5WLL6|||http://purl.uniprot.org/uniprot/G7PHP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:LOC102118453 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIT2 ^@ Similarity ^@ Belongs to the SPT20 family. http://togogenome.org/gene/9541:FOXG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X839 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ANTXR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/9541:TUBG2 ^@ http://purl.uniprot.org/uniprot/I7GKF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.|||centrosome http://togogenome.org/gene/9541:C12H2orf88 ^@ http://purl.uniprot.org/uniprot/A0A7N9CPM8|||http://purl.uniprot.org/uniprot/A0A8J8XQP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small membrane AKAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PANX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VA54 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/9541:CD28 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCD2|||http://purl.uniprot.org/uniprot/Q0PDN3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:XRN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKV6|||http://purl.uniprot.org/uniprot/A0A8J8YIF4 ^@ Function|||Similarity ^@ Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.|||Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. http://togogenome.org/gene/9541:ATP6AP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAU6 ^@ Similarity ^@ Belongs to the vacuolar ATPase subunit S1 family. http://togogenome.org/gene/9541:ATP1B3 ^@ http://purl.uniprot.org/uniprot/I7G806 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9541:HBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPY9 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. http://togogenome.org/gene/9541:PDE8A ^@ http://purl.uniprot.org/uniprot/A0A2K5VH55 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:RNASE1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAJ9|||http://purl.uniprot.org/uniprot/G7P9M4 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9541:LDLRAD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEJ9|||http://purl.uniprot.org/uniprot/A0A7N9C7V6|||http://purl.uniprot.org/uniprot/I7GJY8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:UBE2E3 ^@ http://purl.uniprot.org/uniprot/I7G5F9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:AXIN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYD6|||http://purl.uniprot.org/uniprot/A0A2K5TYE7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||Membrane|||Nucleus http://togogenome.org/gene/9541:AVPR1A ^@ http://purl.uniprot.org/uniprot/E3V2E3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. http://togogenome.org/gene/9541:IQSEC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJG9 ^@ Similarity ^@ Belongs to the BRAG family. http://togogenome.org/gene/9541:ZNF213 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2G0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FAT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXC1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:GNA12 ^@ http://purl.uniprot.org/uniprot/I7GI11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-alpha family. G(12) subfamily.|||Membrane http://togogenome.org/gene/9541:ANKRD13C ^@ http://purl.uniprot.org/uniprot/A0A2K5TT21 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:DOCK11 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7R3|||http://purl.uniprot.org/uniprot/A0A2K5X856 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9541:NIF3L1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CS85|||http://purl.uniprot.org/uniprot/A0A7N9DDN3|||http://purl.uniprot.org/uniprot/A0A8J8XNX5|||http://purl.uniprot.org/uniprot/G7PL60|||http://purl.uniprot.org/uniprot/I7GHS9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family.|||Cytoplasm|||Homodimer. Interacts with COPS2. Interacts with THOC7.|||May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.|||Nucleus http://togogenome.org/gene/9541:LOC102143668 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7C3 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Theta family.|||Homodimer. http://togogenome.org/gene/9541:LOC123566751 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PLAC1 family.|||Secreted http://togogenome.org/gene/9541:NDUFB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U416 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB4 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ALAS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGP3|||http://purl.uniprot.org/uniprot/Q4R6D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:TMEM43 ^@ http://purl.uniprot.org/uniprot/A0A7N9I9H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM43 family.|||Membrane http://togogenome.org/gene/9541:C19H19orf54 ^@ http://purl.uniprot.org/uniprot/A0A2K5W917|||http://purl.uniprot.org/uniprot/A0A7N9CGI7 ^@ Similarity ^@ Belongs to the UPF0692 family. http://togogenome.org/gene/9541:MOB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7E2 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9541:GNAT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8X8|||http://purl.uniprot.org/uniprot/A0A8J8XRP4 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9541:CTPS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3G0|||http://purl.uniprot.org/uniprot/G7NUE2 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/9541:OSBPL9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIC3|||http://purl.uniprot.org/uniprot/A0A2K5VII1|||http://purl.uniprot.org/uniprot/A0A2K5VIN8 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9541:HTR1B ^@ http://purl.uniprot.org/uniprot/G7P3H1 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.|||Homodimer. Heterodimer with HTR1D.|||Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.|||Membrane|||Palmitoylated.|||Phosphorylated. http://togogenome.org/gene/9541:EPHA5 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6J5|||http://purl.uniprot.org/uniprot/A0A2K5W6J6|||http://purl.uniprot.org/uniprot/A0A2K5W6M9|||http://purl.uniprot.org/uniprot/A0A7N9D0P2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TRIM32 ^@ http://purl.uniprot.org/uniprot/A0A8J8YEP3|||http://purl.uniprot.org/uniprot/G7PRK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Nucleus http://togogenome.org/gene/9541:MMP8 ^@ http://purl.uniprot.org/uniprot/A0A2K5V406 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9541:GK2 ^@ http://purl.uniprot.org/uniprot/Q4R4D5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGGY kinase family.|||Cytoplasm|||Interacts with ARMC12 and PLD6.|||Key enzyme in the regulation of glycerol uptake and metabolism. Essential for male fertility and sperm mitochondrial sheath formation (By similarity). Required for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during spermatogenesis (By similarity). Can induce mitochondrial clustering through interactions with PLD6 and up-regulation of phosphatidic acid synthesis in the mitochondria (By similarity).|||Mitochondrion outer membrane http://togogenome.org/gene/9541:DUSP29 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMM7 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9541:TUB ^@ http://purl.uniprot.org/uniprot/A0A2K5UYI9|||http://purl.uniprot.org/uniprot/A0A2K5UYJ4|||http://purl.uniprot.org/uniprot/A0A2K5UYM7|||http://purl.uniprot.org/uniprot/G7PQT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUB family.|||Secreted http://togogenome.org/gene/9541:CSMD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGA3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:SCGN ^@ http://purl.uniprot.org/uniprot/A0A8J8YES1|||http://purl.uniprot.org/uniprot/G7P4K7 ^@ Subcellular Location Annotation ^@ secretory vesicle membrane http://togogenome.org/gene/9541:UBE2D4 ^@ http://purl.uniprot.org/uniprot/A0A7N9CTY0|||http://purl.uniprot.org/uniprot/A0A7N9D203|||http://purl.uniprot.org/uniprot/A0A7N9D2F9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:SERPINF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNU6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:ARFGEF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVR7 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||perinuclear region http://togogenome.org/gene/9541:DNAJA1 ^@ http://purl.uniprot.org/uniprot/Q4R6Z9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:D2HGDH ^@ http://purl.uniprot.org/uniprot/A0A7N9ICP3 ^@ Similarity ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family. http://togogenome.org/gene/9541:CGA ^@ http://purl.uniprot.org/uniprot/G7P3J5|||http://purl.uniprot.org/uniprot/Q9BEH3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.|||Heterodimer. The active hormones thyrotropin, lutropin, follitropin and choriogonadotropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin, FSHB for follitropin and choriogonadotropin subunit beta/CGB for choriogonadotropin.|||Secreted|||Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. http://togogenome.org/gene/9541:TGS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN56 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family. http://togogenome.org/gene/9541:RAB3D ^@ http://purl.uniprot.org/uniprot/A0A2K5TXE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9541:KRTCAP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM54 family.|||Membrane http://togogenome.org/gene/9541:SH3GL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIB0|||http://purl.uniprot.org/uniprot/A0A7N9CLV0|||http://purl.uniprot.org/uniprot/A0A7N9D207 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/9541:SMG9 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1U7 ^@ Similarity ^@ Belongs to the SMG9 family. http://togogenome.org/gene/9541:RAD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UF89|||http://purl.uniprot.org/uniprot/A0A7N9D9C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad1 family.|||Nucleus http://togogenome.org/gene/9541:RALA ^@ http://purl.uniprot.org/uniprot/A0A2K5TV78|||http://purl.uniprot.org/uniprot/G8F2X3 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/9541:TPP1 ^@ http://purl.uniprot.org/uniprot/Q4R4L8 ^@ Cofactor|||Subcellular Location Annotation ^@ Binds 1 Ca(2+) ion per subunit.|||Melanosome http://togogenome.org/gene/9541:LIG3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCB2|||http://purl.uniprot.org/uniprot/A0A2K5VCG8|||http://purl.uniprot.org/uniprot/G7PU29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/9541:DCLRE1A ^@ http://purl.uniprot.org/uniprot/A0A2K5TQZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9541:DEFB114 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4F6|||http://purl.uniprot.org/uniprot/G7P4U4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:ARF1 ^@ http://purl.uniprot.org/uniprot/A0A158SIP9|||http://purl.uniprot.org/uniprot/Q4R5P2 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Alternates between an inactive GDP-bound form and an active GTP-bound form. Intrinsic GTPase activity is almost undetectable in vitro. Activated by guanine nucleotide-exchange factors (GEFs) and inactivated by GTPase-activating proteins (GAPs).|||Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus|||Golgi apparatus membrane|||Interacts with ARHGAP21, ASAP2, GGA1, HERC1, PRKCABP, PIP5K1B, TMED2, PSCD2, TMED10 and GRIA2. Interacts with ARFGAP1, which hydrolyzes GTP and thus, regulates its function. Interacts with PI4KB in the Golgi complex. Interacts with NCS1/FREQ in the Golgi and at the plasma membrane. Interacts with PLEKHA3. Interacts with PLEKHA8; the interaction, together with phosphatidylinositol 4-phosphate binding, is required for FAPP2-mediated glucosylceramide transfer activity. Interacts (activated) with PICK1 (via PDZ domain); the interaction blocks Arp2/3 complex inhibition. Interacts with IQSEC1. Interacts with C9orf72.|||Postsynaptic density|||Small GTPase involved in protein trafficking between different compartments. Modulates vesicle budding and uncoating within the Golgi complex. In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity). The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (By similarity).|||synaptosome http://togogenome.org/gene/9541:ERG ^@ http://purl.uniprot.org/uniprot/A0A2K5UZL3|||http://purl.uniprot.org/uniprot/A0A2K5UZM9|||http://purl.uniprot.org/uniprot/A0A2K5UZT5|||http://purl.uniprot.org/uniprot/A0A2K5UZU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:BCAP31 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||Membrane|||Plays a role in the export of secreted proteins in the ER. http://togogenome.org/gene/9541:C6H5orf24 ^@ http://purl.uniprot.org/uniprot/G7P8B2 ^@ Similarity ^@ Belongs to the UPF0461 family. http://togogenome.org/gene/9541:CSTF2T ^@ http://purl.uniprot.org/uniprot/G8F2J6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ASB7 ^@ http://purl.uniprot.org/uniprot/A0A8J8YNA7|||http://purl.uniprot.org/uniprot/G7P9J5 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:MTMR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WF20|||http://purl.uniprot.org/uniprot/A0A2K5WF31|||http://purl.uniprot.org/uniprot/A0A2K5WF62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:TFCP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXR1|||http://purl.uniprot.org/uniprot/A0A7N9IEW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9541:GTF2H4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIY7|||http://purl.uniprot.org/uniprot/A0A8J8YN01|||http://purl.uniprot.org/uniprot/G7P4M6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.|||Nucleus http://togogenome.org/gene/9541:GCNT2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CM24|||http://purl.uniprot.org/uniprot/A0A8J8Y4A2|||http://purl.uniprot.org/uniprot/G7P4D9 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:PSMA2 ^@ http://purl.uniprot.org/uniprot/Q4R6R9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9541:MPDZ ^@ http://purl.uniprot.org/uniprot/A0A2K5V3R8|||http://purl.uniprot.org/uniprot/A0A2K5V3V7 ^@ Subcellular Location Annotation ^@ tight junction http://togogenome.org/gene/9541:LOC102126768 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSN1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9541:DHX9 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DEAH subfamily.|||Nucleus http://togogenome.org/gene/9541:DAW1 ^@ http://purl.uniprot.org/uniprot/Q4R8E7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR69 family.|||May play a role in axonemal outer row dynein assembly.|||cilium http://togogenome.org/gene/9541:LSM12 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVE5 ^@ Similarity ^@ Belongs to the LSM12 family. http://togogenome.org/gene/9541:EDIL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYU3|||http://purl.uniprot.org/uniprot/A0A2K5WYU7|||http://purl.uniprot.org/uniprot/A0A2K5WYV1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PRPSAP1 ^@ http://purl.uniprot.org/uniprot/A0A7N9DCF7|||http://purl.uniprot.org/uniprot/A0A7N9IDC8|||http://purl.uniprot.org/uniprot/Q4R428 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/9541:SERBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0G7|||http://purl.uniprot.org/uniprot/A0A2K5X0J0|||http://purl.uniprot.org/uniprot/A0A7N9CX01|||http://purl.uniprot.org/uniprot/Q4R9B2 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:ASB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVR7 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:HEXIM2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YBN7|||http://purl.uniprot.org/uniprot/G7PV18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HEXIM family.|||Nucleus http://togogenome.org/gene/9541:EXOC3L2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UL86 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/9541:NOVA1 ^@ http://purl.uniprot.org/uniprot/Q2PFW9 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion or exclusion. It binds specifically to the sequences 5'-YCAY-3' and regulates splicing in only a subset of regulated exons. Binding to an exonic 5'-YCAY-3' cluster changes the protein complexes assembled on pre-mRNA, blocking U1 snRNP binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhances spliceosome assembly and exon inclusion. Binding to 5'-YCAY-3' clusters results in a local and asymmetric action to regulate spliceosome assembly and alternative splicing in neurons. Binding to an exonic 5'-YCAY-3' cluster changed the protein complexes assembled on pre-mRNA, blocking U1 snRNP (small nuclear ribonucleoprotein) binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhanced spliceosome assembly and exon inclusion. With NOVA1, they perform unique biological functions in different brain areas and cell types. Autoregulates its own expression by acting as a splicing repressor. Acts to activate the inclusion of exon E3A in the glycine receptor alpha-2 chain and of exon E9 in gamma-aminobutyric-acid receptor gamma-2 subunit via a distal downstream UCAU-rich intronic splicing enhancer. Acts to regulate a novel glycine receptor alpha-2 chain splice variant (alpha-2N) in developing spinal cord.|||Interacts with PTBP2; the interaction is direct.|||Nucleus|||The KH domain consists of approximately 70 amino acids and includes a conserved hydrophobic core, an invariant Gly-X-X-Gly motif, and an additional variable segment. The third KH domain (KH3) binds a hairpin RNA loop containing the 5'-UCAY-3' motif on targeted molecules. RNA binding by KH3 requires residues C-terminal to the KH domain. http://togogenome.org/gene/9541:TSPAN1 ^@ http://purl.uniprot.org/uniprot/G7NV03|||http://purl.uniprot.org/uniprot/Q4R7W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9541:POLB ^@ http://purl.uniprot.org/uniprot/Q2PFM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Cytoplasm|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus|||Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. http://togogenome.org/gene/9541:SULT2B1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YDJ6|||http://purl.uniprot.org/uniprot/G7PY24 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9541:GNAS ^@ http://purl.uniprot.org/uniprot/Q2PFZ8 ^@ Similarity ^@ Belongs to the G-alpha family. G(s) subfamily. http://togogenome.org/gene/9541:CIAO2B ^@ http://purl.uniprot.org/uniprot/A0A2K5TVX0 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/9541:SLC29A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL78|||http://purl.uniprot.org/uniprot/G7P406 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/9541:LANCL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSB6|||http://purl.uniprot.org/uniprot/A0A7N9D691 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/9541:LOC102140552 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9541:SLC2A5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZD6|||http://purl.uniprot.org/uniprot/A0A7N9IEN2 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane|||sarcolemma http://togogenome.org/gene/9541:LOC102142483 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZR0|||http://purl.uniprot.org/uniprot/A0A7N9I9J5 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9541:PARG ^@ http://purl.uniprot.org/uniprot/A0A2K5VGN9 ^@ Similarity ^@ Belongs to the poly(ADP-ribose) glycohydrolase family. http://togogenome.org/gene/9541:PSME3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WT28|||http://purl.uniprot.org/uniprot/Q4R4V3 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at the major site Lys-195 is important for oligomerization and ability to degrade its target substrates. Deacetylated by SIRT1 (By similarity).|||Belongs to the PA28 family.|||Cytoplasm|||Homoheptamer; the stability of the heptamer is essential for the specific activation of the trypsine-like subunit and inhibition of the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits of the proteasome. Interacts with p53/TP53, MDM2 and MAP3K3. Associates with the proteasome. Interacts with CCAR2. Interacts with PSME3IP1 (via C-terminus); the interaction is direct and promotes the association of PSME3 with the 20S proteasome. Interacts with COIL; the interaction is inhibited by PSME3IP1.|||Nucleus|||Phosphorylated by MAP3K3. Phosphorylation at Ser-247 promotes its association with CCAR2.|||Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (By similarity).|||The C-terminal sequences affect heptamer stability and proteasome affinity. http://togogenome.org/gene/9541:CHD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJJ5|||http://purl.uniprot.org/uniprot/A0A2K5UJP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/9541:SLC7A11 ^@ http://purl.uniprot.org/uniprot/A0A8J8XHH6|||http://purl.uniprot.org/uniprot/G7P6A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Membrane http://togogenome.org/gene/9541:UBE2S ^@ http://purl.uniprot.org/uniprot/A0A2K5U991 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:KEG98_p07 ^@ http://purl.uniprot.org/uniprot/C3W4Z1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane http://togogenome.org/gene/9541:TLR8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9541:ZEB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5URR5|||http://purl.uniprot.org/uniprot/A0A2K5URS4 ^@ Similarity ^@ Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. http://togogenome.org/gene/9541:PPP3CC ^@ http://purl.uniprot.org/uniprot/A0A2K5UDC3 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/9541:PLA2G3 ^@ http://purl.uniprot.org/uniprot/A0A2K5USI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/9541:LOC102123220 ^@ http://purl.uniprot.org/uniprot/Q4R784 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9541:POLR1E ^@ http://purl.uniprot.org/uniprot/A0A2K5VTT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.|||nucleolus http://togogenome.org/gene/9541:DPM3 ^@ http://purl.uniprot.org/uniprot/G7NV63 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM3 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. http://togogenome.org/gene/9541:TFAP2C ^@ http://purl.uniprot.org/uniprot/A0A2K5WDE8|||http://purl.uniprot.org/uniprot/A0A2K5WDG7 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9541:HEBP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YGT6|||http://purl.uniprot.org/uniprot/G7PJW7 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/9541:HMGN4 ^@ http://purl.uniprot.org/uniprot/A0A7N9CUD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9541:CYRIA ^@ http://purl.uniprot.org/uniprot/A0A8J8XXW2|||http://purl.uniprot.org/uniprot/G7PLN0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CYRI family.|||Interacts with RAC1 (GTP-bound form preferentially).|||Membrane http://togogenome.org/gene/9541:DCST1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0Q0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CRYAB ^@ http://purl.uniprot.org/uniprot/G7PNS7|||http://purl.uniprot.org/uniprot/Q60HG8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small heat shock protein (HSP20) family.|||Cytoplasm|||Heteromer composed of three CRYAA and one CRYAB subunits. Aggregates with homologous proteins, including the small heat shock protein HSPB1, to form large heteromeric complexes. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Interacts with HSPBAP1 and TTN/titin. Interacts with TMEM109. Interacts with DES; binds rapidly during early stages of DES filament assembly and a reduced binding seen in the later stages. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Interacts with ATP6V1A and with MTOR, forming a ternary complex (By similarity).|||Lysosome|||May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.|||May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity).|||Nucleus|||Secreted http://togogenome.org/gene/9541:UBA52 ^@ http://purl.uniprot.org/uniprot/P0C273 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs.|||Cytoplasm|||Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.|||Nucleus|||Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy. Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30.|||Ribosomal protein L40 is part of the 60S ribosomal subunit. Interacts with UBQLN1 (via UBA domain).|||Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. http://togogenome.org/gene/9541:CYP4F2 ^@ http://purl.uniprot.org/uniprot/A8CBR4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:LOC102117721 ^@ http://purl.uniprot.org/uniprot/G7P2L6|||http://purl.uniprot.org/uniprot/G7P2M7|||http://purl.uniprot.org/uniprot/G7P2P0 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:SPDEF ^@ http://purl.uniprot.org/uniprot/A0A8J8XPV0|||http://purl.uniprot.org/uniprot/G7P2U3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:CAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:DNASE2B ^@ http://purl.uniprot.org/uniprot/I7GM04 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/9541:HMX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVH9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:RRN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U608 ^@ Similarity ^@ Belongs to the RRN3 family. http://togogenome.org/gene/9541:TSR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U792|||http://purl.uniprot.org/uniprot/A0A7N9CWW3 ^@ Function|||Similarity ^@ Belongs to the TSR2 family.|||May be involved in 20S pre-rRNA processing. http://togogenome.org/gene/9541:RGS8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VA48|||http://purl.uniprot.org/uniprot/A0A2K5VA51 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Nucleus|||Perikaryon|||dendrite http://togogenome.org/gene/9541:IL36A ^@ http://purl.uniprot.org/uniprot/A0A2K5UTG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9541:RNF152 ^@ http://purl.uniprot.org/uniprot/A0A8J8YFA8|||http://purl.uniprot.org/uniprot/G7PWW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNF152 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9541:MAN1B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1J4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9541:CDH19 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEG2 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ATP6V1G3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMY6|||http://purl.uniprot.org/uniprot/G7NWH6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9541:CEP55 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVH8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:TRIM45 ^@ http://purl.uniprot.org/uniprot/A0A2K5X306 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:FNTA ^@ http://purl.uniprot.org/uniprot/A0A2K5V989 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/9541:ATG7 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y178|||http://purl.uniprot.org/uniprot/G7NYH8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG7 family.|||Cytoplasm|||E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.|||Homodimer.|||Preautophagosomal structure http://togogenome.org/gene/9541:C6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3S5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complement C6/C7/C8/C9 family.|||Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.|||Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:MUSK ^@ http://purl.uniprot.org/uniprot/A0A2K5USF6|||http://purl.uniprot.org/uniprot/A0A2K5USG2|||http://purl.uniprot.org/uniprot/A0A2K5USG5 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:ATP5F1A ^@ http://purl.uniprot.org/uniprot/A0A2K5TVD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/9541:ARPIN ^@ http://purl.uniprot.org/uniprot/A0A2K5VUL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Arpin family.|||lamellipodium http://togogenome.org/gene/9541:TRAPPC6A ^@ http://purl.uniprot.org/uniprot/A0A2K5WBX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/9541:C8B ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ42|||http://purl.uniprot.org/uniprot/G8F445 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:SRP19 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPZ6|||http://purl.uniprot.org/uniprot/A0A2K5TPZ7|||http://purl.uniprot.org/uniprot/A0A7N9CAU8|||http://purl.uniprot.org/uniprot/G8F2L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP19 family.|||Cytoplasm http://togogenome.org/gene/9541:HDAC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0C9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/9541:PAM ^@ http://purl.uniprot.org/uniprot/A0A2K5U511|||http://purl.uniprot.org/uniprot/A0A2K5U515|||http://purl.uniprot.org/uniprot/A0A2K5U526 ^@ Similarity|||Subcellular Location Annotation ^@ In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.|||In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.|||Membrane|||secretory vesicle membrane http://togogenome.org/gene/9541:PPP1R35 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP1R35 family.|||centriole http://togogenome.org/gene/9541:CDC25C ^@ http://purl.uniprot.org/uniprot/A0A2K5V9Q2|||http://purl.uniprot.org/uniprot/Q4R6H0 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/9541:KCNMA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSK6|||http://purl.uniprot.org/uniprot/A0A2K5VSL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.|||Membrane http://togogenome.org/gene/9541:TMPO ^@ http://purl.uniprot.org/uniprot/A0A2K5WJG4|||http://purl.uniprot.org/uniprot/A0A2K5WJJ6|||http://purl.uniprot.org/uniprot/A0A2K5WJJ9|||http://purl.uniprot.org/uniprot/A0A7N9DAL4 ^@ Similarity ^@ Belongs to the LEM family. http://togogenome.org/gene/9541:FUT9 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZV7|||http://purl.uniprot.org/uniprot/G7P425 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9541:TBCC ^@ http://purl.uniprot.org/uniprot/A0A2K5W8E9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCC family.|||Cytoplasm|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. http://togogenome.org/gene/9541:LMX1B ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ26 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:S100A8 ^@ http://purl.uniprot.org/uniprot/A0A2K5X560 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9541:RNPS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYG9|||http://purl.uniprot.org/uniprot/G7Q091|||http://purl.uniprot.org/uniprot/Q4R5N1 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the splicing factor SR family.|||Cytoplasm|||Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10 (By similarity).|||Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.|||Nucleus|||Nucleus speckle|||Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions (By similarity).|||Phosphorylated on one or more of the four Ser/Thr residues (Ser-43, Thr-49, Ser-52 or Ser-53). Ser-53 phosphorylation site is important for splicing and translation stimulation activity in vitro (By similarity).|||The RRM domain is required for the formation of the ASAP complex. http://togogenome.org/gene/9541:SNRPD3 ^@ http://purl.uniprot.org/uniprot/A0A7N9I9G4|||http://purl.uniprot.org/uniprot/G7PHE1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays role in pre-mRNA splicing as core component of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.|||cytosol http://togogenome.org/gene/9541:MGAT5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XC29|||http://purl.uniprot.org/uniprot/G7PN39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 18 family.|||Golgi apparatus membrane|||Membrane|||Secreted http://togogenome.org/gene/9541:ARL8A ^@ http://purl.uniprot.org/uniprot/A0A2K5UB31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Synapse|||axon|||spindle http://togogenome.org/gene/9541:LMBRD1 ^@ http://purl.uniprot.org/uniprot/Q4R5E3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LIMR family. LMBRD1 subfamily.|||Cell membrane|||Interacts with ABCD4; this interaction induces the translocation of ABCD4 from the endoplasmic reticulum to the lysosome. Interacts with ABCD4 and MMACHC; this interaction ensures the transport of cobalamin from the lysosome to the cytoplasm (By similarity). Interacts with INSR, adapter protein complex 2 and clathrin heavy chain (By similarity).|||Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosomal membrane. Then forms a complex with lysosomal transporter ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity).|||Lysosome membrane|||N-glycosylated.|||clathrin-coated vesicle http://togogenome.org/gene/9541:ADORA2B ^@ http://purl.uniprot.org/uniprot/A0A2K5UDV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/9541:SLC10A1 ^@ http://purl.uniprot.org/uniprot/A2V9Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9541:LOC102133117 ^@ http://purl.uniprot.org/uniprot/A0A7N9D7R8 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/9541:TMEM178B ^@ http://purl.uniprot.org/uniprot/A0A2K5VJF5 ^@ Similarity ^@ Belongs to the TMEM178 family. http://togogenome.org/gene/9541:ZFP36L1 ^@ http://purl.uniprot.org/uniprot/I7GKC6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/9541:GRK6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTN2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9541:GDPD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUN2 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9541:LOC102119667 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQN8 ^@ Similarity ^@ Belongs to the Schlafen family. Subgroup III subfamily. http://togogenome.org/gene/9541:ATP10A ^@ http://purl.uniprot.org/uniprot/A0A2K5WLS9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TM4SF5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9541:ME3 ^@ http://purl.uniprot.org/uniprot/I7GL37 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/9541:CPT1A ^@ http://purl.uniprot.org/uniprot/A0A2K5UZT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:LOC102120366 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBY3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:FH ^@ http://purl.uniprot.org/uniprot/I7GLU3 ^@ Function|||Similarity ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. http://togogenome.org/gene/9541:CAPZA2 ^@ http://purl.uniprot.org/uniprot/Q4R5G1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).|||Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity). http://togogenome.org/gene/9541:CRISP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4E5 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:VWF ^@ http://purl.uniprot.org/uniprot/A0A2K5X4G5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.|||Multimeric. Interacts with F8.|||Secreted|||extracellular matrix http://togogenome.org/gene/9541:UROD ^@ http://purl.uniprot.org/uniprot/A0A2K5V2R0 ^@ Similarity|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Homodimer. http://togogenome.org/gene/9541:CDC37L1 ^@ http://purl.uniprot.org/uniprot/G7PSF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/9541:FOXJ3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WH51|||http://purl.uniprot.org/uniprot/A0A2K5WHE4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SPIRE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TW43|||http://purl.uniprot.org/uniprot/A0A2K5TW48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spire family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/9541:TSN ^@ http://purl.uniprot.org/uniprot/A0A2K5VL45|||http://purl.uniprot.org/uniprot/A0A2K5VL61 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the translin family.|||DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.|||Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.|||Nucleus|||Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring. http://togogenome.org/gene/9541:FGFR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.|||Cell membrane|||Cytoplasmic vesicle|||Membrane|||Nucleus|||Vesicle|||cytosol http://togogenome.org/gene/9541:PRKACB ^@ http://purl.uniprot.org/uniprot/A0A2K5VK60|||http://purl.uniprot.org/uniprot/A0A2K5VKF1|||http://purl.uniprot.org/uniprot/A0A2K5VKF2|||http://purl.uniprot.org/uniprot/A0A2K5VKH9|||http://purl.uniprot.org/uniprot/A0A2K5VKP3|||http://purl.uniprot.org/uniprot/G7NX32 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/9541:RTCB ^@ http://purl.uniprot.org/uniprot/G7PF98|||http://purl.uniprot.org/uniprot/Q4R6X4 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Catalytic component of the tRNA-splicing ligase complex.|||Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.|||Cytoplasm|||Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.|||Nucleus http://togogenome.org/gene/9541:TRIM46 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMA3|||http://purl.uniprot.org/uniprot/G8F697 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:CCK ^@ http://purl.uniprot.org/uniprot/I7GJF3|||http://purl.uniprot.org/uniprot/P23362 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gastrin/cholecystokinin family.|||Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain.|||Secreted|||The precursor is cleaved by ACE, which removes the Gly-Arg-Arg peptide at the C-terminus, leading to mature hormone.|||The precursor is cleaved by proteases to produce a number of active cholecystokinins.|||This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. http://togogenome.org/gene/9541:GPBP1L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSE3|||http://purl.uniprot.org/uniprot/G8F2B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/9541:BLOC1S2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1Y3|||http://purl.uniprot.org/uniprot/A0A2K5U220|||http://purl.uniprot.org/uniprot/Q4R7C8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BLOC1S2 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May play a role in cell proliferation.|||Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Interacts directly with BLOC1S1, BLOC1S3, BLOC1S4, BLOC1S5 and SNAPIN. The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos. Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. Interacts with gamma-tubulin. Interacts with IFT57.|||Lysosome membrane|||centrosome http://togogenome.org/gene/9541:C18H18orf32 ^@ http://purl.uniprot.org/uniprot/I7G4M0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UPF0729 family.|||Interacts with DERL1 and AMFR.|||May activate the NF-kappa-B signaling pathway. http://togogenome.org/gene/9541:KPNA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WX73 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9541:AK4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMF2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/9541:DYRK1A ^@ http://purl.uniprot.org/uniprot/A0A2K5VA44 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/9541:CNR2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAP5|||http://purl.uniprot.org/uniprot/G7NVV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:P2RX3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XY24|||http://purl.uniprot.org/uniprot/G7PQ42 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9541:GREB1L ^@ http://purl.uniprot.org/uniprot/A0A2K5W577 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GREB1 family.|||Membrane http://togogenome.org/gene/9541:NPPB ^@ http://purl.uniprot.org/uniprot/A0A2K5V0K8|||http://purl.uniprot.org/uniprot/G8F4Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/9541:PHACTR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGF4|||http://purl.uniprot.org/uniprot/A0A2K5UGH5|||http://purl.uniprot.org/uniprot/A0A2K5UGL9|||http://purl.uniprot.org/uniprot/A0A2K5UGM6 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/9541:CRYL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFB8 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/9541:MTFP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YHQ5|||http://purl.uniprot.org/uniprot/G7PF69 ^@ Similarity ^@ Belongs to the MTFP1 family. http://togogenome.org/gene/9541:SPRN ^@ http://purl.uniprot.org/uniprot/A0A2K5UMX7 ^@ Function|||Similarity ^@ Belongs to the SPRN family.|||Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP. http://togogenome.org/gene/9541:NOB1 ^@ http://purl.uniprot.org/uniprot/Q4R537 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NOB1 family.|||May interact with UPF2 (By similarity). Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex) (By similarity).|||May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity).|||Nucleus http://togogenome.org/gene/9541:ACSM1 ^@ http://purl.uniprot.org/uniprot/G7Q0M8 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9541:DGKZ ^@ http://purl.uniprot.org/uniprot/A0A2K5V5H0 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9541:SLC35E1 ^@ http://purl.uniprot.org/uniprot/G7PZQ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CNDP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQW4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9541:PDE4D ^@ http://purl.uniprot.org/uniprot/A0A2K5VWF6|||http://purl.uniprot.org/uniprot/A0A2K5VWG8|||http://purl.uniprot.org/uniprot/A0A2K5VWJ8|||http://purl.uniprot.org/uniprot/A0A2K5VWK7|||http://purl.uniprot.org/uniprot/A0A2K5VWK9|||http://purl.uniprot.org/uniprot/A0A2K5VWL9|||http://purl.uniprot.org/uniprot/A0A2K5VWR4|||http://purl.uniprot.org/uniprot/A0A7N9D392 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:RPS21 ^@ http://purl.uniprot.org/uniprot/A0A2K5U026 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the 40S small ribosomal subunit.|||Endoplasmic reticulum|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/9541:LARS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8T1 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:MEN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2P9|||http://purl.uniprot.org/uniprot/G7PPQ8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:RARS1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XGN1|||http://purl.uniprot.org/uniprot/G7P6U6 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:NDUFAB1 ^@ http://purl.uniprot.org/uniprot/I7GLC6 ^@ Function|||Similarity ^@ Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis. http://togogenome.org/gene/9541:PDGFC ^@ http://purl.uniprot.org/uniprot/A0A2K5V0S6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:ACOT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWS0|||http://purl.uniprot.org/uniprot/I7GIT8|||http://purl.uniprot.org/uniprot/Q4R4J8 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9541:SLC7A8 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9B8|||http://purl.uniprot.org/uniprot/A0A8J8YCV3|||http://purl.uniprot.org/uniprot/G7P9V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Membrane http://togogenome.org/gene/9541:LRRC8A ^@ http://purl.uniprot.org/uniprot/A0A2K5VRD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SLC5A9 ^@ http://purl.uniprot.org/uniprot/A0A2K5WU11|||http://purl.uniprot.org/uniprot/A0A2K5WU21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9541:RRP1B ^@ http://purl.uniprot.org/uniprot/A0A2K5X2F9 ^@ Similarity ^@ Belongs to the RRP1 family. http://togogenome.org/gene/9541:LOC102145420 ^@ http://purl.uniprot.org/uniprot/A0A7N9D6B8|||http://purl.uniprot.org/uniprot/A0A8J8YFM8|||http://purl.uniprot.org/uniprot/G7PLA8 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9541:GIMAP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9G2|||http://purl.uniprot.org/uniprot/I7GJF8 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9541:LOC102144433 ^@ http://purl.uniprot.org/uniprot/A0A2K5TP58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:STARD8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSY2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:LOC102144463 ^@ http://purl.uniprot.org/uniprot/A0A2K5WD85 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9541:ATP5PF ^@ http://purl.uniprot.org/uniprot/Q8SPH6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ATPase subunit F6 family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/9541:GGCX ^@ http://purl.uniprot.org/uniprot/A0A8J8XEH1|||http://purl.uniprot.org/uniprot/G7PMM1 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.|||Membrane http://togogenome.org/gene/9541:CTNNA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W256 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vinculin/alpha-catenin family.|||cytoskeleton http://togogenome.org/gene/9541:KCTD10 ^@ http://purl.uniprot.org/uniprot/A0A2K5U754 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BACURD family.|||Cell membrane http://togogenome.org/gene/9541:NR6A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:RHPN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V419 ^@ Similarity ^@ Belongs to the RHPN family. http://togogenome.org/gene/9541:KPNA6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X9F2 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9541:NDUFA13 ^@ http://purl.uniprot.org/uniprot/Q4R6H1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.|||Belongs to the complex I NDUFA13 subunit family.|||Complex I is composed of 45 different subunits. Interacts with CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with OLFM4.|||Mitochondrion inner membrane|||Nucleus http://togogenome.org/gene/9541:LLPH ^@ http://purl.uniprot.org/uniprot/A0A2K5X0J3 ^@ Similarity ^@ Belongs to the learning-associated protein family. http://togogenome.org/gene/9541:UPP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8D7|||http://purl.uniprot.org/uniprot/A0A8J8XDU8|||http://purl.uniprot.org/uniprot/G7P1S6 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. http://togogenome.org/gene/9541:PDCL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXR2 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9541:ADGRG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTP0|||http://purl.uniprot.org/uniprot/A0A2K5TTP6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ENTR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNU6 ^@ Similarity ^@ Belongs to the ENTR1 family. http://togogenome.org/gene/9541:STARD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UV30 ^@ Function ^@ May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. http://togogenome.org/gene/9541:SPOCK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X517|||http://purl.uniprot.org/uniprot/A0A2K5X528 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PAPOLG ^@ http://purl.uniprot.org/uniprot/A0A2K5W0K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Nucleus http://togogenome.org/gene/9541:VPS35 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXA3|||http://purl.uniprot.org/uniprot/A0A2K5WXX7 ^@ Function|||Similarity ^@ Belongs to the VPS35 family.|||Plays a role in vesicular protein sorting. http://togogenome.org/gene/9541:LNPK ^@ http://purl.uniprot.org/uniprot/A0A2K5TXW3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lunapark family.|||Endoplasmic reticulum membrane|||Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.|||Plays a role in determining ER morphology.|||The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. http://togogenome.org/gene/9541:ZDHHC17 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZT6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:CNNM4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V329 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ACDP family.|||Membrane http://togogenome.org/gene/9541:PAX5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLQ1|||http://purl.uniprot.org/uniprot/A0A2K5VM65|||http://purl.uniprot.org/uniprot/G7PRX3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:NDFIP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAN9 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/9541:SFXN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2P2|||http://purl.uniprot.org/uniprot/A0A8J8XHZ4|||http://purl.uniprot.org/uniprot/G7P6Y2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9541:HEXIM1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQK1|||http://purl.uniprot.org/uniprot/G7PV17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HEXIM family.|||Nucleus http://togogenome.org/gene/9541:MCF2L ^@ http://purl.uniprot.org/uniprot/A0A2K5UTV6|||http://purl.uniprot.org/uniprot/A0A2K5UU46|||http://purl.uniprot.org/uniprot/A0A2K5UU51 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:TEX261 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVP26 family.|||Membrane http://togogenome.org/gene/9541:RPS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6W4 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS5 family.|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. http://togogenome.org/gene/9541:TELO2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W515 ^@ Similarity ^@ Belongs to the TEL2 family. http://togogenome.org/gene/9541:ASZ1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3L9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation. http://togogenome.org/gene/9541:GDF5 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4R5 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9541:EIF3E ^@ http://purl.uniprot.org/uniprot/A0A2K5X1X1|||http://purl.uniprot.org/uniprot/Q4R6G8 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit E family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2 (By similarity). Interacts with IFIT1 and IFIT2 (By similarity). Interacts with BZW2/5MP1 (By similarity).|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||PML body|||Phosphorylated upon DNA damage, probably by ATM or ATR. http://togogenome.org/gene/9541:NFIB ^@ http://purl.uniprot.org/uniprot/A0A2K5W5D7|||http://purl.uniprot.org/uniprot/A0A2K5W5F4|||http://purl.uniprot.org/uniprot/G7PSC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/9541:PTH1R ^@ http://purl.uniprot.org/uniprot/A0A2K5V724 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:BRF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U738|||http://purl.uniprot.org/uniprot/A0A2K5U741 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/9541:AGXT ^@ http://purl.uniprot.org/uniprot/A0A2K5VWZ4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Peroxisome http://togogenome.org/gene/9541:LOC102146578 ^@ http://purl.uniprot.org/uniprot/A0A2K5UX20 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9541:LOC102146577 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJS7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9541:ATP2C1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X252|||http://purl.uniprot.org/uniprot/A0A2K5X263|||http://purl.uniprot.org/uniprot/A0A2K5X271 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Golgi stack membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. Homodimer.|||trans-Golgi network membrane http://togogenome.org/gene/9541:SEPTIN5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKW4|||http://purl.uniprot.org/uniprot/A0A2K5WKW7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments.|||cytoskeleton http://togogenome.org/gene/9541:NEUROD6 ^@ http://purl.uniprot.org/uniprot/G7P0G5|||http://purl.uniprot.org/uniprot/Q4R5G6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene (By similarity).|||Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/9541:ADAM8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VED6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:ATXN2L ^@ http://purl.uniprot.org/uniprot/A0A2K5UTW7 ^@ Similarity ^@ Belongs to the ataxin-2 family. http://togogenome.org/gene/9541:TAF1B ^@ http://purl.uniprot.org/uniprot/Q4R657 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although it shares weak sequence similarity with GTF2B/TFIIB, displays a similar subdomain organization as GTF2B/TFIIB, with a N-terminal zinc finger, a connecting region (composed of B-reader and B-linker regions), followed by 2 cyclin folds. The RRN7-type zinc finger plays an essential postrecruitment role in Pol I transcription at a step preceding synthesis of the first 40 nucleotides (By similarity).|||Belongs to the RRN7/TAF1B family.|||Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3 (By similarity).|||Interacts with FLNA (via N-terminus) (By similarity). Component of the transcription factor SL1/TIF-IB complex, notably composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1C. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with TBP and RRN3 (By similarity).|||nucleolus http://togogenome.org/gene/9541:MATK ^@ http://purl.uniprot.org/uniprot/A0A2K5UQL7|||http://purl.uniprot.org/uniprot/A0A2K5UQS4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9541:LOC102122931 ^@ http://purl.uniprot.org/uniprot/A0A7N9D2E9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ACAA1 ^@ http://purl.uniprot.org/uniprot/Q2PG05 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9541:GAB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAB8 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/9541:SMS ^@ http://purl.uniprot.org/uniprot/A0A2K5U1T0 ^@ Similarity ^@ Belongs to the spermidine/spermine synthase family. http://togogenome.org/gene/9541:SOD2 ^@ http://purl.uniprot.org/uniprot/Q8HXP3 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).|||Belongs to the iron/manganese superoxide dismutase family.|||Binds 1 Mn(2+) ion per subunit.|||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.|||Homotetramer.|||Mitochondrion matrix|||Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.|||Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability. http://togogenome.org/gene/9541:AMOT ^@ http://purl.uniprot.org/uniprot/A0A2K5V135 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/9541:FGF11 ^@ http://purl.uniprot.org/uniprot/A0A2K5W996 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:SLC22A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UY99 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/9541:EMC9 ^@ http://purl.uniprot.org/uniprot/A0A2K5W141 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/9541:KCNH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ71 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TP53INP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V686 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/9541:DLGAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1M8 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9541:CSMD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V697 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:SRMS ^@ http://purl.uniprot.org/uniprot/A0A2K5TQL8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9541:PUS7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSQ6 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/9541:IL18R1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3J9|||http://purl.uniprot.org/uniprot/A0A2K5V3M1 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9541:TMEM38B ^@ http://purl.uniprot.org/uniprot/A0A2K5X7D5|||http://purl.uniprot.org/uniprot/A0A7N9CP35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/9541:CALB1 ^@ http://purl.uniprot.org/uniprot/G7PC68 ^@ Function|||Similarity|||Subunit ^@ Belongs to the calbindin family.|||Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.|||Interacts with RANBP9. http://togogenome.org/gene/9541:PLSCR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0T4 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9541:SCAMP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3C2|||http://purl.uniprot.org/uniprot/A0A2K5V3F8|||http://purl.uniprot.org/uniprot/G8F6B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9541:PAQR6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFH4|||http://purl.uniprot.org/uniprot/A0A2K5VFH9|||http://purl.uniprot.org/uniprot/A0A7N9CSG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9541:YWHAH ^@ http://purl.uniprot.org/uniprot/Q4R5L9 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9541:CAPN2 ^@ http://purl.uniprot.org/uniprot/Q9GLG1 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin.|||Belongs to the peptidase C2 family.|||Binds 7 Ca(2+) ions.|||Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs.|||Cell membrane|||Cytoplasm|||Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Interacts with CPEB3; this leads to cleavage of CPEB3. http://togogenome.org/gene/9541:C7 ^@ http://purl.uniprot.org/uniprot/A0A2K5W920|||http://purl.uniprot.org/uniprot/A0A7N9IA03 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:C15H9orf24 ^@ http://purl.uniprot.org/uniprot/Q95LU0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMRP1 family.|||Cytoplasm|||Interacts with alpha-tubulin.|||May play a role in spermatogenesis. May be involved in differentiation or function of ciliated cells (By similarity).|||Nucleus|||cytoskeleton http://togogenome.org/gene/9541:CEMIP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3E0|||http://purl.uniprot.org/uniprot/A0A2K5W3F2 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/9541:LOC107126403 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOR1AIP family.|||Membrane http://togogenome.org/gene/9541:FAM149B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WD96 ^@ Similarity ^@ Belongs to the FAM149 family. http://togogenome.org/gene/9541:DCPS ^@ http://purl.uniprot.org/uniprot/A0A7N9CFJ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HIT family.|||Cytoplasm|||Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.|||Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.|||Nucleus http://togogenome.org/gene/9541:GALR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9541:B4GAT1 ^@ http://purl.uniprot.org/uniprot/Q4R5D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 49 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:EIF2B4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM05|||http://purl.uniprot.org/uniprot/A0A7N9CP23 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/9541:LOC102123561 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ANK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDJ8|||http://purl.uniprot.org/uniprot/A0A2K5VDM2|||http://purl.uniprot.org/uniprot/A0A2K5VE75 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PPP2R5C ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ21|||http://purl.uniprot.org/uniprot/A0A2K5TZ49|||http://purl.uniprot.org/uniprot/A0A2K5TZ66 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9541:LLGL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTW0 ^@ Similarity ^@ Belongs to the WD repeat L(2)GL family. http://togogenome.org/gene/9541:GRB7 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3C0|||http://purl.uniprot.org/uniprot/A0A2K5U3C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/9541:ZKSCAN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPZ5|||http://purl.uniprot.org/uniprot/G7Q0S1 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:PEX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3L5|||http://purl.uniprot.org/uniprot/A0A7N9D5I7 ^@ Function|||Similarity ^@ Belongs to the pex2/pex10/pex12 family.|||Somewhat implicated in the biogenesis of peroxisomes. http://togogenome.org/gene/9541:SH3GLB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM88|||http://purl.uniprot.org/uniprot/A0A7N9D5S5|||http://purl.uniprot.org/uniprot/A0A7N9DF74|||http://purl.uniprot.org/uniprot/G7NTL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Golgi apparatus membrane|||Membrane|||Midbody|||Mitochondrion outer membrane|||autophagosome membrane http://togogenome.org/gene/9541:LOC102123935 ^@ http://purl.uniprot.org/uniprot/Q9XT55 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the UDP-glycosyltransferase family.|||Contributes to the formation of androgen glucuronide in extrahepatic steroid target tissues such as the prostate.|||Endoplasmic reticulum membrane|||Expressed in liver, ovary, prostate, colon, kidney, pancreas, brain, cerebellum, mammary gland and epididymis. Not expressed in small intestine, spleen, bladder, adrenal gland and testis.|||Microsome membrane|||UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates: eugenol, 4-methyllumbelliferone, p-nitrophenol, 1-naphthol, p,p'-biphenol, naringenin and o,o'-biphenol. Active also on 3a-hydroxy and 17b-hydroxy positions of steroids. http://togogenome.org/gene/9541:ELL ^@ http://purl.uniprot.org/uniprot/A0A2K5VPN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Nucleus http://togogenome.org/gene/9541:MRPS9 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXZ9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/9541:ENTPD8 ^@ http://purl.uniprot.org/uniprot/A0A2K5U016 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9541:GPI ^@ http://purl.uniprot.org/uniprot/A0A2K5W4A2|||http://purl.uniprot.org/uniprot/Q4R591 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPI family.|||Cytoplasm|||Homodimer; in the catalytically active form. Monomer in the secreted form.|||ISGylated.|||In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity).|||Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by a non-classical secretory pathway.|||Secreted http://togogenome.org/gene/9541:CPLX1 ^@ http://purl.uniprot.org/uniprot/Q4R4N1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complexin/synaphin family.|||Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.|||Perikaryon|||Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity).|||Presynapse|||cytosol http://togogenome.org/gene/9541:TSHB ^@ http://purl.uniprot.org/uniprot/A0A2K5X6T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9541:MMP15 ^@ http://purl.uniprot.org/uniprot/A0A2K5U664 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9541:SZRD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUQ7|||http://purl.uniprot.org/uniprot/A0A7N9CZQ5 ^@ Similarity ^@ Belongs to the SZRD1 family. http://togogenome.org/gene/9541:GUCA2A ^@ http://purl.uniprot.org/uniprot/A0A2K5UVW5|||http://purl.uniprot.org/uniprot/G7NUE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/9541:PCMTD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U399 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9541:NEFL ^@ http://purl.uniprot.org/uniprot/A0A2K5UWG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||cytoskeleton http://togogenome.org/gene/9541:TOP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1H4 ^@ Function|||Similarity ^@ Belongs to the type IB topoisomerase family.|||Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/9541:EXO5 ^@ http://purl.uniprot.org/uniprot/A0A8J8YFL1|||http://purl.uniprot.org/uniprot/G7NUD7 ^@ Similarity ^@ Belongs to the EXO5 family. http://togogenome.org/gene/9541:NR2F2 ^@ http://purl.uniprot.org/uniprot/A0A7N9D8M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:SDC2 ^@ http://purl.uniprot.org/uniprot/I7G7X8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9541:ALDH8A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPT0|||http://purl.uniprot.org/uniprot/A0A2K5TPT1|||http://purl.uniprot.org/uniprot/A0A2K5TPV0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9541:TMEM91 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZP0|||http://purl.uniprot.org/uniprot/A0A7N9C7K4 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:PPIP5K2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZZ2|||http://purl.uniprot.org/uniprot/A0A2K5UZZ9|||http://purl.uniprot.org/uniprot/A0A2K5V009|||http://purl.uniprot.org/uniprot/A0A2K5V029|||http://purl.uniprot.org/uniprot/A0A8J8Y795|||http://purl.uniprot.org/uniprot/G7P809 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family. VIP1 subfamily.|||Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).|||cytosol http://togogenome.org/gene/9541:CHST4 ^@ http://purl.uniprot.org/uniprot/A0A7N9CXJ4|||http://purl.uniprot.org/uniprot/Q4R9F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9541:EIF4A2 ^@ http://purl.uniprot.org/uniprot/Q4R4Y9 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).|||Belongs to the DEAD box helicase family. eIF4A subfamily.|||eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIFFG3 (By similarity). Interacts with EIF4E. May interact with NOM1 (By similarity). http://togogenome.org/gene/9541:ECH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDG5|||http://purl.uniprot.org/uniprot/A0A2K5VDI1 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9541:LOC102129383 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNE6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:ADI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U577 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acireductone dioxygenase (ARD) family.|||Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.|||Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14.|||Cell membrane|||Cytoplasm|||Monomer. Interacts with MMP14.|||Nucleus http://togogenome.org/gene/9541:CHRM2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XET9|||http://purl.uniprot.org/uniprot/G7P0W8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. http://togogenome.org/gene/9541:CEBPE ^@ http://purl.uniprot.org/uniprot/A0A7N9D2L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/9541:CDKL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WC50 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:LOC102146894 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMH9 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/9541:SH3BGRL ^@ http://purl.uniprot.org/uniprot/G7Q351|||http://purl.uniprot.org/uniprot/Q4R7R5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs. May function as a ubiquitin ligase-substrate adapter. Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs.|||Belongs to the SH3BGR family.|||Cell membrane|||Monomer. Interacts with PFN1/Profilin-1. Interacts with ERBB2. Interacts with ATG12. Interacts with BECN1. Interacts with translating ribosomes.|||The SH3-binding domain is buried in the tertiary structure, and it therefore unclear whether it directly mediates protein-binding.|||cytosol http://togogenome.org/gene/9541:CLIC2 ^@ http://purl.uniprot.org/uniprot/G7Q239 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9541:EIF4EBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6X5 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/9541:LYPLA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFV7|||http://purl.uniprot.org/uniprot/A0A2K5VG09 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/9541:CSAD ^@ http://purl.uniprot.org/uniprot/A0A2K5UXF0 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/9541:HTR1D ^@ http://purl.uniprot.org/uniprot/A0A2K5UMI0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Homodimer. Heterodimer with HTR1B.|||Membrane http://togogenome.org/gene/9541:ACVR1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XB86|||http://purl.uniprot.org/uniprot/G7PKM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9541:IL15 ^@ http://purl.uniprot.org/uniprot/A0A2K5VG93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/9541:SLC44A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/9541:LOC101926433 ^@ http://purl.uniprot.org/uniprot/A0A2K5U698|||http://purl.uniprot.org/uniprot/A0A2K5U6B3|||http://purl.uniprot.org/uniprot/A0A2K5U6L3|||http://purl.uniprot.org/uniprot/P53601 ^@ Caution|||Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Amyloid-beta peptides are degraded by IDE.|||Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Binds transient metals such as copper, zinc and iron (By similarity).|||Belongs to the APP family.|||Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, MAPK8IP1, SHC1 and NUMB and DAB1 (By similarity). Binding to DAB1 inhibits its serine phosphorylation (By similarity). Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif. Also interacts with GPCR-like protein BPP, APPBP1, IB1, KNS2 (via its TPR domains), APPBP2 (via BaSS) and DDB1. In vitro, it binds MAPT via the MT-binding domains (By similarity). Associates with microtubules in the presence of ATP and in a kinesin-dependent manner (By similarity). Interacts, through a C-terminal domain, with GNAO1. Amyloid-beta protein 42 binds CHRNA7 in hippocampal neurons (By similarity). Amyloid-beta associates with HADH2 (By similarity). Interacts with CPEB1, ANKS1B, TNFRSF21 and AGER (By similarity). Interacts with ITM2B. Interacts with ITM2C. Interacts with IDE. Can form homodimers; dimerization is enhanced in the presence of Cu(2+) ions. Can form homodimers; this is promoted by heparin binding (By similarity). Amyloid-beta protein 40 interacts with S100A9 (By similarity). CTF-alpha product of APP interacts with GSAP (By similarity). Isoform APP695 interacts with SORL1 (via N-terminal ectodomain); this interaction retains APP in the trans-Golgi network and reduces processing into soluble APP-alpha and amyloid-beta peptides (By similarity). Isoform APP770 interacts with SORL1 (By similarity). The C99 fragment also interacts with SORL1 (By similarity). Interacts with PLD3 (By similarity). Interacts with VDAC1 (By similarity). Interacts with NSG1; could regulate APP processing (By similarity). Amyloid-beta protein 42 interacts with FPR2 (By similarity). Interacts (via transmembrane region) with PSEN1; the interaction is direct (By similarity). Interacts with LRRK2 (By similarity). Interacts (via cytoplasmic domain) with KIF5B (By similarity). Interacts (via C-terminus) with APBB2/FE65L1 (via C-terminus) (By similarity). Interacts (via intracellular domain) with APBB3 (By similarity).|||Cell membrane|||Cell surface|||Chelation of metal ions, notably copper, iron and zinc, can induce histidine-bridging between amyloid-beta molecules resulting in amyloid-beta-metal aggregates. Extracellular zinc-binding increases binding of heparin to APP and inhibits collagen-binding.|||Cytoplasm|||Cytoplasmic vesicle|||Early endosome|||Endoplasmic reticulum|||Endosome|||Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.|||Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP (By similarity). Inhibits G(o)-alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapes in axons (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction (By similarity). In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation (By similarity). Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity).|||Golgi apparatus|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N- and O-glycosylated.|||N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).|||Nucleus|||Perikaryon|||Phosphorylation in the C-terminal on tyrosine, threonine and serine residues is neuron-specific. Phosphorylation can affect APP processing, neuronal differentiation and interaction with other proteins. Phosphorylated on Thr-743 in neuronal cells by Cdc5 kinase and Mapk10, in dividing cells by Cdc2 kinase in a cell-cycle dependent manner with maximal levels at the G2/M phase and, in vitro, by GSK-3-beta. The Thr-743 phosphorylated form causes a conformational change which reduces binding of Fe65 family members. In dopaminergic (DA) neurons, phosphorylation on Thr-743 by LRKK2 promotes the production and the nuclear translocation of the APP intracellular domain (AICD) which induces DA neuron apoptosis. Phosphorylation on Tyr-757 is required for SHC binding. Phosphorylated in the extracellular domain by casein kinases on both soluble and membrane-bound APP. This phosphorylation is inhibited by heparin.|||Proteolytically cleaved by caspases during neuronal apoptosis. Cleavage at Asp-739 by either caspase-3, -8 or -9 results in the production of the neurotoxic C31 peptide and the increased production of amyloid-beta peptides.|||Proteolytically processed under normal cellular conditions. Cleavage either by alpha-secretase, beta-secretase or theta-secretase leads to generation and extracellular release of soluble APP peptides, S-APP-alpha and S-APP-beta, and the retention of corresponding membrane-anchored C-terminal fragments, C80, C83 and C99. Subsequent processing of C80 and C83 by gamma-secretase yields P3 peptides. This is the major secretory pathway and is non-amyloidogenic. Alternatively, presenilin/nicastrin-mediated gamma-secretase processing of C99 releases the amyloid-beta proteins, amyloid-beta protein 40 and amyloid-beta protein 42, major components of amyloid plaques, and the cytotoxic C-terminal fragments, gamma-CTF(50), gamma-CTF(57) and gamma-CTF(59). PSEN1 cleavage is more efficient with C83 than with C99 as substrate (in vitro). Amyloid-beta protein 40 and Amyloid-beta protein 42 are cleaved by ACE. Many other minor amyloid-beta peptides, amyloid-beta 1-X peptides, are found in cerebral spinal fluid (CSF) including the amyloid-beta X-15 peptides, produced from the cleavage by alpha-secretase.|||Secreted|||Sulfated on tyrosine residues.|||The C-terminal region can bind zinc ions; this favors dimerization and formation of higher oligomers.|||The GFLD subdomain binds Cu(2+) ions; this promotes homodimerization.|||The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The PID domain-containing proteins which bind APP require the YENPTY motif for full interaction. These interactions are independent of phosphorylation on the terminal tyrosine residue. The YENPXY site is also involved in clathrin-mediated endocytosis.|||The OX-2 motif shows some similarity to a region in the N-terminus of CD200/MOX2.|||The basolateral sorting signal (BaSS) is required for sorting of membrane proteins to the basolateral surface of epithelial cells.|||The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.|||The transmembrane helix undergoes a conformation change and unravels partially when bound to PSEN1, facilitating cleavage by PSEN1.|||Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP).|||Vesicle|||clathrin-coated pit|||growth cone http://togogenome.org/gene/9541:TAMM41 ^@ http://purl.uniprot.org/uniprot/A0A2K5U470|||http://purl.uniprot.org/uniprot/A0A2K5U4B8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAM41 family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:CLDN19 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHK0|||http://purl.uniprot.org/uniprot/A0A7N9C8X1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:IFNK ^@ http://purl.uniprot.org/uniprot/G7PS65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9541:TBX21 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0N8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:ICMT ^@ http://purl.uniprot.org/uniprot/A0A2K5UYR5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.|||Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:DOK6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W216|||http://purl.uniprot.org/uniprot/A0A7N9CHL0 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9541:PRICKLE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1F3|||http://purl.uniprot.org/uniprot/A0A2K5X1N1 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9541:MYBBP1A ^@ http://purl.uniprot.org/uniprot/A0A2K5VX19 ^@ Similarity ^@ Belongs to the MYBBP1A family. http://togogenome.org/gene/9541:LOC102114868 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5C2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:DLG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR33|||http://purl.uniprot.org/uniprot/A0A2K5TR55|||http://purl.uniprot.org/uniprot/A0A2K5TR59|||http://purl.uniprot.org/uniprot/A0A2K5TR64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Membrane http://togogenome.org/gene/9541:SNW1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TM10|||http://purl.uniprot.org/uniprot/A0A2K5TM20 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNW family.|||Identified in the spliceosome C complex.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9541:ACTL8 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4N5|||http://purl.uniprot.org/uniprot/G7NUR7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:HPSE ^@ http://purl.uniprot.org/uniprot/A0A2K5UQU0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/9541:TMEM19 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1C6|||http://purl.uniprot.org/uniprot/G7PI22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/9541:MCM7 ^@ http://purl.uniprot.org/uniprot/Q4R3W8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9541:HOXA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0V9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:HARBI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZV8|||http://purl.uniprot.org/uniprot/G7PQB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HARBI1 family.|||Cytoplasm|||Nucleus|||Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity. http://togogenome.org/gene/9541:CRK ^@ http://purl.uniprot.org/uniprot/A0A2K5X7X9 ^@ Similarity ^@ Belongs to the CRK family. http://togogenome.org/gene/9541:PLPP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WD95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9541:PTTG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the securin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:MAPK6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6X6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9541:DDX43 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDJ5 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9541:CLDN16 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:FAM221B ^@ http://purl.uniprot.org/uniprot/A0A2K5TXZ4|||http://purl.uniprot.org/uniprot/G7PRZ1 ^@ Similarity ^@ Belongs to the FAM221 family. http://togogenome.org/gene/9541:KEG98_p02 ^@ http://purl.uniprot.org/uniprot/C3W4Z6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9541:PHYHIPL ^@ http://purl.uniprot.org/uniprot/A0A2K5WMU6|||http://purl.uniprot.org/uniprot/G7PDF2 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/9541:AQP2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CSL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9541:TLCD3A ^@ http://purl.uniprot.org/uniprot/A0A2K5TJW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PDHA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULH9 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. http://togogenome.org/gene/9541:SPATA24 ^@ http://purl.uniprot.org/uniprot/Q4R7I4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SPATA24 family.|||Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis (By similarity).|||Cytoplasm|||Homodimer. Interacts with CBX3, CBX5, GMNN, GTF2B, TBPL1 and the polycomb proteins PHCF2, RNF2 and SCMH1 but not with CBX1 or PCGF2.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9541:TMEM218 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM218 family.|||May be involved in ciliary biogenesis or function.|||Membrane|||cilium http://togogenome.org/gene/9541:HDAC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/9541:MNAT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UA85|||http://purl.uniprot.org/uniprot/A0A2K5UA91 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with CDK7 and cyclin H.|||Nucleus|||Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. http://togogenome.org/gene/9541:FXN ^@ http://purl.uniprot.org/uniprot/Q8HXX9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the frataxin family.|||Component of the mitochondrial core iron-sulfur cluster (ISC) complex composed of NFS1, LYRM4, NDUFAB1, ISCU, FXN, and FDX2; this complex is an heterohexamer containing two copies of each monomer. Homodimer. Monomer (probable predominant form). Oligomer. Monomers and polymeric aggregates of >1 MDa have been isolated from mitochondria. A small fraction of heterologous overexpressed recombinant frataxin forms high-molecular weight aggregates that incorporate iron. Interacts with LYRM4. Interacts (via ferrous form) with ISCU; the interaction is possible when both are bound to the dimeric form of the cysteine desulfurase complex (NFS1:LYRM4) and the interaction enhances FXN interaction to the dimeric form of the cysteine desulfurase complex (NFS1:LYRM4) (By similarity). Interacts with FECH; one iron-bound FXN monomer seems to interact with a FECH homodimer. Interacts with SDHA and SDHB (By similarity). Interacts with ACO2; the interaction is dependent on citrate (By similarity). Interacts with HSPA9 (By similarity).|||Functions as an activator of persulfide transfer to the scaffoding protein ISCU as component of the core iron-sulfur cluster (ISC) assembly complex and participates to the [2Fe-2S] cluster assembly. Accelerates sulfur transfer from NFS1 persulfide intermediate to ISCU and to small thiols such as L-cysteine and glutathione leading to persulfuration of these thiols and ultimately sulfide release. Binds ferrous ion and is released from FXN upon the addition of both L-cysteine and reduced FDX2 during [2Fe-2S] cluster assembly (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. May function as an iron chaperone protein that protects the aconitase [4Fe-4S]2+ cluster from disassembly and promotes enzyme reactivation. May play a role as a high affinity iron binding partner for FECH that is capable of both delivering iron to ferrochelatase and mediating the terminal step in mitochondrial heme biosynthesis (By similarity).|||Interacts with ACO1. Interacts with ISCU (cytoplasmic form).|||Mitochondrion|||Modulates the RNA-binding activity of ACO1. May be involved in the cytoplasmic iron-sulfur protein biogenesis. May contribute to oxidative stress resistance and overall cell survival.|||Processed in two steps by mitochondrial processing peptidase (MPP). MPP first cleaves the precursor to intermediate form and subsequently converts the intermediate to yield frataxin mature form (frataxin(81-210)) which is the predominant form. The additional forms, frataxin(56-210) and frataxin(78-210), seem to be produced when the normal maturation process is impaired; their physiological relevance is unsure.|||cytosol http://togogenome.org/gene/9541:GDF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0D5 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9541:IL1RL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDB8 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9541:KCNH6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X943|||http://purl.uniprot.org/uniprot/A0A2K5X9I4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:MED19 ^@ http://purl.uniprot.org/uniprot/A0A2K5WF72 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 19 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9541:SEPTIN6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7M6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9541:MAP3K21 ^@ http://purl.uniprot.org/uniprot/A0A2K5UG78 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Homodimer.|||Homodimerization via the leucine zipper domains is required for autophosphorylation. http://togogenome.org/gene/9541:LOC102123903 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ELSPBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBA0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:FAM234B ^@ http://purl.uniprot.org/uniprot/A0A2K5TQD1 ^@ Similarity ^@ Belongs to the FAM234 family. http://togogenome.org/gene/9541:DPEP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YK92|||http://purl.uniprot.org/uniprot/G7PZZ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.|||Cell membrane|||Homodimer; disulfide-linked.|||Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.|||Membrane http://togogenome.org/gene/9541:CDC42EP4 ^@ http://purl.uniprot.org/uniprot/I7GEW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9541:LHCGR ^@ http://purl.uniprot.org/uniprot/A0A2K5V283 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||Membrane|||Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. http://togogenome.org/gene/9541:LOC102144646 ^@ http://purl.uniprot.org/uniprot/A0A8J8XP23|||http://purl.uniprot.org/uniprot/G7PVB2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family. http://togogenome.org/gene/9541:GJD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UF43 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9541:NUCB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKV7|||http://purl.uniprot.org/uniprot/A0A2K5WKW3 ^@ Similarity ^@ Belongs to the nucleobindin family. http://togogenome.org/gene/9541:COQ3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFL2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Mitochondrion inner membrane|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/9541:RICTOR ^@ http://purl.uniprot.org/uniprot/A0A2K5V3Q7|||http://purl.uniprot.org/uniprot/A0A2K5V3T3 ^@ Similarity ^@ Belongs to the RICTOR family. http://togogenome.org/gene/9541:CRYBB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPY4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/9541:UBAC2 ^@ http://purl.uniprot.org/uniprot/Q4R910 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Endoplasmic reticulum membrane|||Interacts with LMBR1L, FAF2, AMFR and VCP (By similarity).|||Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets (By similarity). In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). http://togogenome.org/gene/9541:ANXA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7S4|||http://purl.uniprot.org/uniprot/A0A8J8XSE0|||http://purl.uniprot.org/uniprot/G7P536 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9541:CWF19L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUK7|||http://purl.uniprot.org/uniprot/A0A2K5UUP3 ^@ Similarity ^@ Belongs to the CWF19 family. http://togogenome.org/gene/9541:ABI2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UV69|||http://purl.uniprot.org/uniprot/A0A2K5UV84|||http://purl.uniprot.org/uniprot/A0A2K5UVD3|||http://purl.uniprot.org/uniprot/A0A7N9CIX9|||http://purl.uniprot.org/uniprot/A0A7N9D0E3|||http://purl.uniprot.org/uniprot/A0A7N9DC51|||http://purl.uniprot.org/uniprot/A0A7N9IF93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9541:SUPV3L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family.|||mitochondrion nucleoid http://togogenome.org/gene/9541:LOC101865693 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6Q3|||http://purl.uniprot.org/uniprot/A0A2K5W6R5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/9541:NDRG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3C1|||http://purl.uniprot.org/uniprot/A0A2K5V3C6|||http://purl.uniprot.org/uniprot/Q4R4K0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NDRG family.|||Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity).|||Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.|||Cytoplasm|||Interacts with CTNNB1.|||growth cone|||perinuclear region http://togogenome.org/gene/9541:LOC102116269 ^@ http://purl.uniprot.org/uniprot/A0A8J8YET7|||http://purl.uniprot.org/uniprot/G7PMI1 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/9541:HOXA11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9541:DYRK1B ^@ http://purl.uniprot.org/uniprot/A0A2K5X0W6|||http://purl.uniprot.org/uniprot/A0A2K5X0X0|||http://purl.uniprot.org/uniprot/A0A2K5X145 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/9541:GML ^@ http://purl.uniprot.org/uniprot/A0A2K5TTQ8|||http://purl.uniprot.org/uniprot/G7PD28 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:TMEM126A ^@ http://purl.uniprot.org/uniprot/A0A8J8YQX2|||http://purl.uniprot.org/uniprot/G7PND4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PGS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V667|||http://purl.uniprot.org/uniprot/G7PSX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-II family.|||Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.|||Mitochondrion http://togogenome.org/gene/9541:MME ^@ http://purl.uniprot.org/uniprot/A0A8J8YT08|||http://purl.uniprot.org/uniprot/G7NZK8 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/9541:HOMER3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UW65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/9541:CFAP91 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJB2 ^@ Similarity ^@ Belongs to the CFAP91 family. http://togogenome.org/gene/9541:RPS6KA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VR69|||http://purl.uniprot.org/uniprot/A0A2K5VRG4|||http://purl.uniprot.org/uniprot/A0A7N9CZK0|||http://purl.uniprot.org/uniprot/A0A7N9IFX3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9541:LRRC42 ^@ http://purl.uniprot.org/uniprot/A0A2K5V482|||http://purl.uniprot.org/uniprot/A0A7N9IFT9 ^@ Similarity ^@ Belongs to the LRRC42 family. http://togogenome.org/gene/9541:AMFR ^@ http://purl.uniprot.org/uniprot/A0A2K5VXW5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:KCTD13 ^@ http://purl.uniprot.org/uniprot/A0A2K5WU44 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:CDS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Membrane http://togogenome.org/gene/9541:MYRF ^@ http://purl.uniprot.org/uniprot/A0A2K5X472 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRF family.|||Membrane http://togogenome.org/gene/9541:B4GALT7 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1V7|||http://purl.uniprot.org/uniprot/A0A2K5U1Y7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9541:HM13 ^@ http://purl.uniprot.org/uniprot/A0A2K5WN40|||http://purl.uniprot.org/uniprot/A0A2K5WN78|||http://purl.uniprot.org/uniprot/G7PGP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/9541:ZNF684 ^@ http://purl.uniprot.org/uniprot/Q4R6J4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:SLC35B4 ^@ http://purl.uniprot.org/uniprot/Q95KB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Golgi apparatus membrane|||Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi. http://togogenome.org/gene/9541:LIMS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U284|||http://purl.uniprot.org/uniprot/A0A2K5U288|||http://purl.uniprot.org/uniprot/A0A8J8XB79|||http://purl.uniprot.org/uniprot/G7PMX1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.|||Cell membrane|||Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.|||focal adhesion http://togogenome.org/gene/9541:TEKT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAH2|||http://purl.uniprot.org/uniprot/G7NTH9|||http://purl.uniprot.org/uniprot/Q4R5V1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tektin family.|||May interact with CCDC172.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.|||Tyrosine phosphorylated.|||cilium axoneme|||flagellum|||flagellum axoneme|||microtubule organizing center http://togogenome.org/gene/9541:SCIN ^@ http://purl.uniprot.org/uniprot/A0A2K5ULY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the villin/gelsolin family.|||cytoskeleton|||podosome http://togogenome.org/gene/9541:KIF16B ^@ http://purl.uniprot.org/uniprot/A0A2K5U450|||http://purl.uniprot.org/uniprot/A0A2K5U453|||http://purl.uniprot.org/uniprot/A0A2K5U469 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:SH3BP5L ^@ http://purl.uniprot.org/uniprot/A0A2K5WLD2|||http://purl.uniprot.org/uniprot/G7NVJ9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SH3BP5 family.|||Cytoplasm|||Functions as guanine nucleotide exchange factor (GEF) for RAB11A.|||Interacts with GDP-bound and nucleotide-free forms of RAB11A.|||The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. http://togogenome.org/gene/9541:DBH ^@ http://purl.uniprot.org/uniprot/A0A2K5WW80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the copper type II ascorbate-dependent monooxygenase family.|||Conversion of dopamine to noradrenaline.|||Homotetramer; composed of two disulfide-linked dimers.|||chromaffin granule lumen|||chromaffin granule membrane|||secretory vesicle lumen|||secretory vesicle membrane http://togogenome.org/gene/9541:SKP1 ^@ http://purl.uniprot.org/uniprot/I7G2L1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SKP1 family.|||Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.|||Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.|||The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. http://togogenome.org/gene/9541:JAKMIP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VY94|||http://purl.uniprot.org/uniprot/A0A2K5VYD8 ^@ Similarity ^@ Belongs to the JAKMIP family. http://togogenome.org/gene/9541:UCHL1 ^@ http://purl.uniprot.org/uniprot/I7GJN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C12 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:CRISP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1H1 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:RPAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ95 ^@ Similarity ^@ Belongs to the RPAP1 family. http://togogenome.org/gene/9541:AAR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQQ1|||http://purl.uniprot.org/uniprot/A0A7N9CY04|||http://purl.uniprot.org/uniprot/Q4R7D0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the AAR2 family.|||Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.|||Interacts with PRPF8 (via RNase H homology domain) (By similarity). Component of a U5 snRNP complex that contains PRPF8 (By similarity). http://togogenome.org/gene/9541:AIG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UG94|||http://purl.uniprot.org/uniprot/A0A2K5UGC1|||http://purl.uniprot.org/uniprot/A0A2K5UGF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/9541:CTSB ^@ http://purl.uniprot.org/uniprot/G7PCE3|||http://purl.uniprot.org/uniprot/Q4R5M2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the peptidase C1 family.|||Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Directly interacts with SHKBP1.|||Lysosome|||Melanosome|||Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity).|||extracellular space http://togogenome.org/gene/9541:RPS6 ^@ http://purl.uniprot.org/uniprot/Q4R4K6 ^@ Function|||PTM|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family.|||Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity).|||Mono-ADP-ribosylation at Glu-35 by PARP16 inhibits polysome assembly and mRNA loading, thereby inhibiting protein translation.|||Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the pre-initiation complex.|||Specifically hydroxylated (with R stereochemistry) at C-3 of Arg-137 by KDM8. http://togogenome.org/gene/9541:EMC10 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7T1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC10 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/9541:LOC102147063 ^@ http://purl.uniprot.org/uniprot/A0A2K5U027|||http://purl.uniprot.org/uniprot/A0A2K5U042 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9541:GPR15 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFW2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:TPD52L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0K9|||http://purl.uniprot.org/uniprot/A0A2K5X0T1|||http://purl.uniprot.org/uniprot/A0A2K5X0T6|||http://purl.uniprot.org/uniprot/A0A2K5X0W8|||http://purl.uniprot.org/uniprot/A0A2K5X164|||http://purl.uniprot.org/uniprot/A0A8J8XXK1|||http://purl.uniprot.org/uniprot/G7P385|||http://purl.uniprot.org/uniprot/I7GIB6 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9541:LIG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UH62 ^@ Similarity ^@ Belongs to the ATP-dependent DNA ligase family. http://togogenome.org/gene/9541:STT3A ^@ http://purl.uniprot.org/uniprot/A0A8J8XKB3|||http://purl.uniprot.org/uniprot/G7PPM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/9541:CDC123 ^@ http://purl.uniprot.org/uniprot/G7PED6|||http://purl.uniprot.org/uniprot/Q2PG37 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC123 family.|||Cytoplasm|||Phosphorylated.|||Required for S phase entry of the cell cycle. http://togogenome.org/gene/9541:LOC102131765 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCF2 ^@ Caution|||Similarity ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PDS5B ^@ http://purl.uniprot.org/uniprot/A0A2K5WHF0|||http://purl.uniprot.org/uniprot/A0A2K5WHL7 ^@ Similarity ^@ Belongs to the PDS5 family. http://togogenome.org/gene/9541:CRH ^@ http://purl.uniprot.org/uniprot/I7G9X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/9541:LALBA ^@ http://purl.uniprot.org/uniprot/A0A8J8YQW7|||http://purl.uniprot.org/uniprot/G7PHQ9 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 22 family.|||Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. http://togogenome.org/gene/9541:NT5E ^@ http://purl.uniprot.org/uniprot/A0A2K5V5U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-nucleotidase family.|||Membrane http://togogenome.org/gene/9541:RPL13A ^@ http://purl.uniprot.org/uniprot/I7GKG8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/9541:GPS1 ^@ http://purl.uniprot.org/uniprot/I7GKA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:OXR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8P8|||http://purl.uniprot.org/uniprot/A0A2K5W8Q1|||http://purl.uniprot.org/uniprot/A0A2K5W8X0|||http://purl.uniprot.org/uniprot/A0A2K5W8X3|||http://purl.uniprot.org/uniprot/A0A2K5W908|||http://purl.uniprot.org/uniprot/A0A2K5W933|||http://purl.uniprot.org/uniprot/A0A2K5W961 ^@ Similarity ^@ Belongs to the OXR1 family. http://togogenome.org/gene/9541:LHX4 ^@ http://purl.uniprot.org/uniprot/A0A7N9DCC7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:COPS4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSQ5|||http://purl.uniprot.org/uniprot/G8F410|||http://purl.uniprot.org/uniprot/Q4R5E6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSN4 family.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).|||Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (By similarity). In the complex, it probably interacts directly with COPS1, COPS2, COPS3, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8 (By similarity). Interacts with TOR1A; the interaction is direct and associates TOR1A and SNAPIN with the CSN complex (By similarity). Interacts with STON2; controls STON2 neddylation levels (By similarity). Interacts with ERCC6 (By similarity).|||Cytoplasm|||Nucleus|||Vesicle|||synaptic vesicle http://togogenome.org/gene/9541:LOC102136805 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:ARMCX1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJD7|||http://purl.uniprot.org/uniprot/G7Q398 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eutherian X-chromosome-specific Armcx family.|||Membrane http://togogenome.org/gene/9541:MB21D2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0U2 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9541:KRT37 ^@ http://purl.uniprot.org/uniprot/A0A8J8YGF7|||http://purl.uniprot.org/uniprot/G7PUR8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:IARS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6T8 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:DNAJC18 ^@ http://purl.uniprot.org/uniprot/A0A2K5TS89|||http://purl.uniprot.org/uniprot/G7P8F2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SLC6A20 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUW3|||http://purl.uniprot.org/uniprot/A0A7N9D6L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9541:XCL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine gamma family.|||Secreted http://togogenome.org/gene/9541:LIPM ^@ http://purl.uniprot.org/uniprot/A0A2K5U9C7 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9541:COPG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U893|||http://purl.uniprot.org/uniprot/A0A7N9IBS2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9541:ALOX15B ^@ http://purl.uniprot.org/uniprot/A0A2K5W767 ^@ Caution|||Similarity ^@ Belongs to the lipoxygenase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:VARS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0R4 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:ADAMTS10 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQJ2 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:RBP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0J2|||http://purl.uniprot.org/uniprot/A0A8J8Y0E2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:LYG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUM1|||http://purl.uniprot.org/uniprot/G8F441 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 23 family. http://togogenome.org/gene/9541:UCK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCT6 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/9541:KIF3B ^@ http://purl.uniprot.org/uniprot/A0A2K5X1D4|||http://purl.uniprot.org/uniprot/G7PGM8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:SLC30A5 ^@ http://purl.uniprot.org/uniprot/A0A2K5W488 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Functions as a zinc transporter.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:RING1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0V4 ^@ Function|||Subcellular Location Annotation ^@ Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.|||Nucleus speckle http://togogenome.org/gene/9541:XDH ^@ http://purl.uniprot.org/uniprot/A0A2K5U0R4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Homodimer. Interacts with BTN1A1.|||Peroxisome http://togogenome.org/gene/9541:LRP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WC84 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LDLR family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:RPL10A ^@ http://purl.uniprot.org/uniprot/Q4R5P3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm http://togogenome.org/gene/9541:LARS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNE4 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:XPO7 ^@ http://purl.uniprot.org/uniprot/A0A2K5USA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:KCNJ3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VD51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9541:MINAR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7D1 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/9541:CDC25A ^@ http://purl.uniprot.org/uniprot/A0A2K5VQI3|||http://purl.uniprot.org/uniprot/A0A2K5VQK3 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/9541:CLSTN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNU5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:IFITM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3Q2 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:CLEC12B ^@ http://purl.uniprot.org/uniprot/A0A2K5TTK1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:DDX51 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU65 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9541:LOC102116314 ^@ http://purl.uniprot.org/uniprot/A0A7N9IHR0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:MON1A ^@ http://purl.uniprot.org/uniprot/A0A2K5VF06|||http://purl.uniprot.org/uniprot/Q95KG9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MON1/SAND family.|||Interacts with CCZ1 (By similarity). Found in a complex with RMC1, CCZ1, MON1A and MON1B (By similarity). The MON1A-CCZ1B complex interacts with RIMOC1 (By similarity). The MON1A-CCZ1B complex interacts with RAB7A and this interaction is enhanced in the presence of RIMOC1 (By similarity).|||Plays an important role in membrane trafficking through the secretory apparatus.|||Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. http://togogenome.org/gene/9541:TADA3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XXL9|||http://purl.uniprot.org/uniprot/G7NYU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGG1 family.|||Nucleus http://togogenome.org/gene/9541:DLST ^@ http://purl.uniprot.org/uniprot/A0A2K5UP28|||http://purl.uniprot.org/uniprot/G8F4U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9541:KIF3A ^@ http://purl.uniprot.org/uniprot/Q4R628 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.|||Heterodimer of KIF3A and KIF3B (By similarity). Interacts with PIFO. Interacts with CLN3 (By similarity). Interacts with DCTN1 (By similarity). Interacts with FLCN. Interacts with AP3B1 (By similarity).|||Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.|||centriole|||cilium|||cytoskeleton http://togogenome.org/gene/9541:TAGLN ^@ http://purl.uniprot.org/uniprot/Q2PG59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calponin family.|||Cytoplasm http://togogenome.org/gene/9541:IYD ^@ http://purl.uniprot.org/uniprot/A0A2K5UT53 ^@ Subcellular Location Annotation ^@ Cell membrane|||Cytoplasmic vesicle membrane http://togogenome.org/gene/9541:SULT1C4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X358 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9541:DGKH ^@ http://purl.uniprot.org/uniprot/A0A2K5WKA0|||http://purl.uniprot.org/uniprot/A0A2K5WKA3|||http://purl.uniprot.org/uniprot/A0A2K5WKA5 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9541:SOX30 ^@ http://purl.uniprot.org/uniprot/Q8WNV5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Acts as both a transcriptional activator and repressor (By similarity). Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif (By similarity). Binds to its own promoter and activates its own transcription (By similarity). Required to activate the expression of postmeiotic genes involved in spermiogenesis (By similarity). Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (By similarity). Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (By similarity).|||Cytoplasm|||Interacts with CTNNB1, competitively inhibiting CTNNB1-TCF7L2/TCF4 interaction.|||Nucleus http://togogenome.org/gene/9541:EGR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDD1|||http://purl.uniprot.org/uniprot/G7PDE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9541:ANO3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2S6|||http://purl.uniprot.org/uniprot/A0A2K5V2T9|||http://purl.uniprot.org/uniprot/A0A7N9DAE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102139291 ^@ http://purl.uniprot.org/uniprot/Q28484 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:OTX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TL55|||http://purl.uniprot.org/uniprot/G7PAC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9541:STEEP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XSK9|||http://purl.uniprot.org/uniprot/G7Q3K3 ^@ Similarity ^@ Belongs to the STEEP1 family. http://togogenome.org/gene/9541:SKA3 ^@ http://purl.uniprot.org/uniprot/I7GJA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SKA3 family.|||kinetochore|||spindle http://togogenome.org/gene/9541:ELAVL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBH7 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/9541:TATDN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2M1|||http://purl.uniprot.org/uniprot/A0A2K5W2V9 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/9541:LOC102119711 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSQ4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:ENPP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W708|||http://purl.uniprot.org/uniprot/A0A2K5W719 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||Binds 1 Ca(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||Secreted http://togogenome.org/gene/9541:LOC102124180 ^@ http://purl.uniprot.org/uniprot/A0A8J8YHN0|||http://purl.uniprot.org/uniprot/G7Q335 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:CLCN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WND4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TGFB3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YEN9|||http://purl.uniprot.org/uniprot/G7PB17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.|||extracellular matrix http://togogenome.org/gene/9541:KCNMB4 ^@ http://purl.uniprot.org/uniprot/A0A7N9CUG2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9541:FOXRED1 ^@ http://purl.uniprot.org/uniprot/Q4R510 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with components of the mitochondrial respiratory chain complex I.|||Mitochondrion inner membrane|||Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly. http://togogenome.org/gene/9541:ZMPSTE24 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKS8|||http://purl.uniprot.org/uniprot/G7NUD2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48A family.|||Binds 1 zinc ion per subunit.|||Endoplasmic reticulum membrane|||Proteolytically removes the C-terminal three residues of farnesylated proteins. http://togogenome.org/gene/9541:PPP4C ^@ http://purl.uniprot.org/uniprot/A0A2K5U642|||http://purl.uniprot.org/uniprot/G7Q0W0 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/9541:ATP11A ^@ http://purl.uniprot.org/uniprot/A0A2K5V167|||http://purl.uniprot.org/uniprot/A0A2K5V170|||http://purl.uniprot.org/uniprot/A0A2K5V1B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9541:LGMN ^@ http://purl.uniprot.org/uniprot/A0A2K5VM53|||http://purl.uniprot.org/uniprot/A0A8J8Y362|||http://purl.uniprot.org/uniprot/G7PWT6 ^@ Similarity ^@ Belongs to the peptidase C13 family. http://togogenome.org/gene/9541:INTS13 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the asunder family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:DCTPP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YLF7|||http://purl.uniprot.org/uniprot/G7Q0X6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Homotetramer.|||Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.|||cytosol http://togogenome.org/gene/9541:TYRO3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:VDAC2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CYU8|||http://purl.uniprot.org/uniprot/I7GHF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic mitochondrial porin family.|||Mitochondrion outer membrane http://togogenome.org/gene/9541:BTF3L4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYY3|||http://purl.uniprot.org/uniprot/G7NVN7 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9541:PYCR2 ^@ http://purl.uniprot.org/uniprot/Q4R6W7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Cytoplasm|||Homodecamer; composed of 5 homodimers. Interacts with LTO1.|||Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity).|||Mitochondrion http://togogenome.org/gene/9541:OPALIN ^@ http://purl.uniprot.org/uniprot/A0A2K5VDN3|||http://purl.uniprot.org/uniprot/A0A7N9D3J9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.|||Membrane http://togogenome.org/gene/9541:KDELR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZJ5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:UCHL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0K6|||http://purl.uniprot.org/uniprot/A0A2K5U0L9|||http://purl.uniprot.org/uniprot/A0A7N9CHK8 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/9541:MRPL2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CAW8|||http://purl.uniprot.org/uniprot/A0A8J8XHY5|||http://purl.uniprot.org/uniprot/G7P3Z3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/9541:GRM5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGU6|||http://purl.uniprot.org/uniprot/A0A2K5WGV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SERPINE1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4W5|||http://purl.uniprot.org/uniprot/G7P138 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:INTS8 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 8 family.|||Nucleus http://togogenome.org/gene/9541:RPL6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0H8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/9541:SF3B3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTN4|||http://purl.uniprot.org/uniprot/G7Q1L4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NUDT21 ^@ http://purl.uniprot.org/uniprot/G7Q156 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. CPSF5 subfamily.|||Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.|||Cytoplasm|||Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.|||Nucleus http://togogenome.org/gene/9541:LOC102136267 ^@ http://purl.uniprot.org/uniprot/Q8SPH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRH/QCR6 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity).|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:RHO ^@ http://purl.uniprot.org/uniprot/Q28886 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore. Upon light absorption, the covalently bound 11-cis-retinal is converted to all-trans-retinal. After hydrolysis of the Schiff base and release of the covalently bound all-trans-retinal, active rhodopsin is regenerated by binding of a fresh molecule of 11-cis-retinal.|||Homodimer. May form a complex composed of RHO, GRK1 and RCVRN in a Ca(2+)-dependent manner; RCVRN prevents the interaction between GRK1 and RHO (By similarity). Interacts with GRK1 (By similarity). Interacts (phosphorylated form) with SAG (By similarity). Interacts with GNAT1 (By similarity). Interacts with GNAT3. SAG and G-proteins compete for a common binding site (By similarity). Interacts with PRCD; the interaction promotes PRCD stability (By similarity).|||Membrane|||Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.|||Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity).|||photoreceptor outer segment http://togogenome.org/gene/9541:SORCS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKD6 ^@ Similarity ^@ Belongs to the VPS10-related sortilin family. SORCS subfamily. http://togogenome.org/gene/9541:TMOD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWU7|||http://purl.uniprot.org/uniprot/G7PBH4 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:PTPN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VN47|||http://purl.uniprot.org/uniprot/A0A2K5VNA0 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. http://togogenome.org/gene/9541:H1-5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9541:LOC102114854 ^@ http://purl.uniprot.org/uniprot/A0A2K5UF33 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/9541:ALG11 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP14 family.|||nucleolus http://togogenome.org/gene/9541:CHIT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUR4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. http://togogenome.org/gene/9541:FSTL1 ^@ http://purl.uniprot.org/uniprot/Q9GKY0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Homodimer (By similarity). Interacts with SCN10A (By similarity). Interacts with DIP2A; DIP2A may act as a cell surface receptor for FSTL1. Interacts with BMP4. Interacts with CD14; this interaction promotes TL4-mediated signaling cascade (By similarity).|||Secreted|||Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (By similarity). Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter. Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity). Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (By similarity). http://togogenome.org/gene/9541:OXSM ^@ http://purl.uniprot.org/uniprot/A0A2K5VNY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.|||Mitochondrion http://togogenome.org/gene/9541:SLC12A7 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9541:CNIH4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YII1|||http://purl.uniprot.org/uniprot/G7NTW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9541:MBTD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRB2|||http://purl.uniprot.org/uniprot/A0A2K5TRD0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SNTB2 ^@ http://purl.uniprot.org/uniprot/I7G453 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||Cell junction|||cytoskeleton http://togogenome.org/gene/9541:NDUFAF4 ^@ http://purl.uniprot.org/uniprot/Q4R4V6 ^@ Similarity|||Subunit ^@ Belongs to the NDUFAF4 family.|||Binds calmodulin. Interacts with NDUFAF3. http://togogenome.org/gene/9541:LOC102120302 ^@ http://purl.uniprot.org/uniprot/G7PUQ5|||http://purl.uniprot.org/uniprot/G7PUQ6 ^@ Subunit ^@ Interacts with hair keratins. http://togogenome.org/gene/9541:CDO1 ^@ http://purl.uniprot.org/uniprot/G7P830|||http://purl.uniprot.org/uniprot/I7G9T5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the cysteine dioxygenase family.|||Binds 1 Fe cation per subunit.|||Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen. http://togogenome.org/gene/9541:GAPVD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9W7|||http://purl.uniprot.org/uniprot/A0A2K5W9Y7|||http://purl.uniprot.org/uniprot/A0A2K5WA01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAPVD1 family.|||Membrane http://togogenome.org/gene/9541:SGCE ^@ http://purl.uniprot.org/uniprot/A0A2K5X7N3|||http://purl.uniprot.org/uniprot/A0A2K5X817|||http://purl.uniprot.org/uniprot/I7G8Y1|||http://purl.uniprot.org/uniprot/Q4R5B1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan alpha/epsilon family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.|||Golgi apparatus|||N-glycosylated.|||Ubiquitinated, leading to its degradation by the proteasome.|||cytoskeleton|||dendrite|||sarcolemma http://togogenome.org/gene/9541:TMEM147 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNQ9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:HORMAD1 ^@ http://purl.uniprot.org/uniprot/Q4R8B9 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Interacts with HORMAD2. Interacts with IHO1.|||Nucleus|||Phosphorylated at Ser-377 in a SPO11-dependent manner.|||Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. http://togogenome.org/gene/9541:NEDD9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCY6|||http://purl.uniprot.org/uniprot/A0A2K5VCZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/9541:LOC102145186 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHL4|||http://purl.uniprot.org/uniprot/I7GNP4 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/9541:SNPH ^@ http://purl.uniprot.org/uniprot/A0A2K5V0S5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PPARG ^@ http://purl.uniprot.org/uniprot/A0A2K5WFM9|||http://purl.uniprot.org/uniprot/A0A2K5WFQ0|||http://purl.uniprot.org/uniprot/A0A8J8YEQ3|||http://purl.uniprot.org/uniprot/Q95J17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Cytoplasm|||Heterodimer with other nuclear receptors.|||Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.|||Nucleus http://togogenome.org/gene/9541:TMC6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/9541:NPR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/9541:LOC102137347 ^@ http://purl.uniprot.org/uniprot/L7TEQ7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:GRB2 ^@ http://purl.uniprot.org/uniprot/Q2PG25 ^@ Subcellular Location Annotation ^@ Endosome|||Golgi apparatus|||Nucleus http://togogenome.org/gene/9541:SERPINB13 ^@ http://purl.uniprot.org/uniprot/A0A7N9CAP2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:CNRIP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y8T3|||http://purl.uniprot.org/uniprot/G7PMC6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. http://togogenome.org/gene/9541:SHMT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXW6|||http://purl.uniprot.org/uniprot/A0A2K5TY05|||http://purl.uniprot.org/uniprot/G7PIU7 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/9541:HOMER2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CMA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/9541:FGF21 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYN8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:SULT6B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGR3 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9541:TCTE1 ^@ http://purl.uniprot.org/uniprot/Q4R642 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DRC5 family.|||Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC. May be required for sperm motility.|||Component of the nexin-dynein regulatory complex (N-DRC). Interacts with FBXL13/DRC6, DRC3 and DRC7.|||flagellum|||flagellum axoneme http://togogenome.org/gene/9541:S100A16 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDV7|||http://purl.uniprot.org/uniprot/G7NUG9 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9541:CHRNG ^@ http://purl.uniprot.org/uniprot/A0A2K5TS72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:GATM ^@ http://purl.uniprot.org/uniprot/I7G8Z1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the amidinotransferase family.|||Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine.|||Homodimer.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:HNRNPH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULQ5|||http://purl.uniprot.org/uniprot/A0A2K5ULQ8 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/9541:TOMM20 ^@ http://purl.uniprot.org/uniprot/A0A2K5WA25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom20 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:GCNT3 ^@ http://purl.uniprot.org/uniprot/G7PBK8 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:SMURF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3B1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:HAL ^@ http://purl.uniprot.org/uniprot/A0A2K5TSK1 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/9541:KCTD18 ^@ http://purl.uniprot.org/uniprot/A0A8J8XEL6|||http://purl.uniprot.org/uniprot/G7PL53 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:DUSP26 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVD9|||http://purl.uniprot.org/uniprot/A0A2K5VVF9|||http://purl.uniprot.org/uniprot/I7G3B6 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9541:DMTN ^@ http://purl.uniprot.org/uniprot/A0A2K5W5E3|||http://purl.uniprot.org/uniprot/A0A2K5W5I5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:DLX5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XWF5|||http://purl.uniprot.org/uniprot/G7P1B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/9541:TPRKB ^@ http://purl.uniprot.org/uniprot/A0A2K5VHW0|||http://purl.uniprot.org/uniprot/G7PMH8 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/9541:GALNT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSB5|||http://purl.uniprot.org/uniprot/G7PKQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:USP13 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6N7 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9541:ARRDC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXR4|||http://purl.uniprot.org/uniprot/A0A8J8YAC8 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9541:MRGPRF ^@ http://purl.uniprot.org/uniprot/I7GAT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane http://togogenome.org/gene/9541:KITLG ^@ http://purl.uniprot.org/uniprot/A0A7N9CAX5|||http://purl.uniprot.org/uniprot/A0A7N9DG76 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCF family.|||Cytoplasm|||Homodimer, non-covalently linked.|||Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.|||Secreted|||filopodium|||lamellipodium http://togogenome.org/gene/9541:ZNF330 ^@ http://purl.uniprot.org/uniprot/I7GKW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOA36 family.|||nucleolus http://togogenome.org/gene/9541:TMEM135 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGX0|||http://purl.uniprot.org/uniprot/A0A2K5UGY7|||http://purl.uniprot.org/uniprot/G7PNE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM135 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9541:ACTBL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGI0 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:A2ML1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X131 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9541:KCNC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ90 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:IKBKE ^@ http://purl.uniprot.org/uniprot/A0A2K5W1S9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:GRB14 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/9541:WNT16 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVE2|||http://purl.uniprot.org/uniprot/A0A8J8YBR9|||http://purl.uniprot.org/uniprot/G7P0J0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:ALG14 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG14 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/9541:ADAM19 ^@ http://purl.uniprot.org/uniprot/A0A2K5X099 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:NPM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGS6 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/9541:TNFSF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTN0|||http://purl.uniprot.org/uniprot/A0A7N9CLL2 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9541:SNX33 ^@ http://purl.uniprot.org/uniprot/A0A2K5TY56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/9541:ART1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCR3 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9541:PSMB11 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEJ4|||http://purl.uniprot.org/uniprot/G7P9U8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:TMEM242 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM242 family.|||Membrane http://togogenome.org/gene/9541:PHB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W040 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Cell membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ACO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TV74 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.|||Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).|||cytosol http://togogenome.org/gene/9541:APOD ^@ http://purl.uniprot.org/uniprot/I7GJN5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Homodimer.|||Secreted http://togogenome.org/gene/9541:COL4A6 ^@ http://purl.uniprot.org/uniprot/A0A2K5V578 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9541:TYMS ^@ http://purl.uniprot.org/uniprot/A0A2K5X3I1 ^@ Similarity ^@ Belongs to the thymidylate synthase family. http://togogenome.org/gene/9541:PRKD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5R6|||http://purl.uniprot.org/uniprot/A0A8J8Y978|||http://purl.uniprot.org/uniprot/G7PM15 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by DAG and phorbol esters.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:GNPDA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5J5|||http://purl.uniprot.org/uniprot/A0A2K5V5N2|||http://purl.uniprot.org/uniprot/G7P8I9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/9541:ACOD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFV3 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/9541:EIF4A1 ^@ http://purl.uniprot.org/uniprot/Q4R8K5 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).|||Belongs to the DEAD box helicase family. eIF4A subfamily.|||eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with PAIP1, EIF4E and UPF2. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. May interact with NOM1. Interacts with PDCD4; this interferes with the interaction between EIF4A and EIF4G. Interacts with RBM4 (By similarity). Interacts with DDX3X in an RNA-independent manner (By similarity). http://togogenome.org/gene/9541:ISYNA1 ^@ http://purl.uniprot.org/uniprot/Q4R6E3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the myo-inositol 1-phosphate synthase family.|||Cytoplasm|||Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). http://togogenome.org/gene/9541:NDUFA7 ^@ http://purl.uniprot.org/uniprot/A0A2K5X150|||http://purl.uniprot.org/uniprot/G8F4P2|||http://purl.uniprot.org/uniprot/I7G5Q1 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA7 subunit family.|||Complex I is composed of 45 different subunits. http://togogenome.org/gene/9541:C14H11orf58 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVN6|||http://purl.uniprot.org/uniprot/A0A8J8YED3 ^@ Similarity ^@ Belongs to the SMAP family. http://togogenome.org/gene/9541:ABCC8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBU1 ^@ Subunit ^@ Interacts with KCNJ11. http://togogenome.org/gene/9541:EFNB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNA1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:GNMT ^@ http://purl.uniprot.org/uniprot/A0A2K5VR98 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. http://togogenome.org/gene/9541:BUD13 ^@ http://purl.uniprot.org/uniprot/A0A2K5VC16 ^@ Similarity ^@ Belongs to the CWC26 family. http://togogenome.org/gene/9541:OXTR ^@ http://purl.uniprot.org/uniprot/E3V2E7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9541:CSF1R ^@ http://purl.uniprot.org/uniprot/A0A2K5WG90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SPATA6L ^@ http://purl.uniprot.org/uniprot/A0A2K5V152 ^@ Similarity ^@ Belongs to the SPATA6 family. http://togogenome.org/gene/9541:NAA11 ^@ http://purl.uniprot.org/uniprot/G7P533 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/9541:CHST8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:KCNJ16 ^@ http://purl.uniprot.org/uniprot/A0A7N9DCS8|||http://purl.uniprot.org/uniprot/A0A8J8XNL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9541:VAX1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CJ56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMX homeobox family.|||Nucleus http://togogenome.org/gene/9541:FBXO27 ^@ http://purl.uniprot.org/uniprot/Q9N0C8 ^@ Function|||Subunit ^@ Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1 (By similarity).|||Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind complex-type oligosaccharides. http://togogenome.org/gene/9541:LOC102135532 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL51 ^@ Similarity ^@ Belongs to the TCAF family. http://togogenome.org/gene/9541:POLR3C ^@ http://purl.uniprot.org/uniprot/A0A8J8YM60|||http://purl.uniprot.org/uniprot/G7NX80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9541:THG1L ^@ http://purl.uniprot.org/uniprot/A0A2K5VWY9|||http://purl.uniprot.org/uniprot/A0A8J8XA90 ^@ Cofactor|||Function|||Similarity ^@ Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.|||Belongs to the tRNA(His) guanylyltransferase family.|||Binds 2 magnesium ions per subunit. http://togogenome.org/gene/9541:PDK2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y3L1|||http://purl.uniprot.org/uniprot/Q4R567 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9541:PIP4P2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VN62 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/9541:EDN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2J8|||http://purl.uniprot.org/uniprot/A0A2K5X2K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9541:ADAM5 ^@ http://purl.uniprot.org/uniprot/Q28483 ^@ Caution|||Developmental Stage|||Function|||PTM|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Detected in elongate spermatids, and in caput and cauda epididymal spermatozoa (at protein level).|||Detected in testis (at protein level). Detected in adult and prepubertal testis. Detected at very low levels in heart, kidney, brain, muscle ovary and uterus.|||Interacts with TEX101.|||Membrane|||Not expected to have protease activity.|||Subject to proteolytic processing during epididymal transit of spermatozoa.|||This is a non catalytic metalloprotease-like protein. May play a role in sperm-egg fusion (By similarity). http://togogenome.org/gene/9541:IMMP2L ^@ http://purl.uniprot.org/uniprot/A0A2K5X380 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family. IMP2 subfamily.|||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:CD3G ^@ http://purl.uniprot.org/uniprot/Q95LI7 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ A di-leucine motif and a tyrosine-based motif are individually sufficient to induce both endocytosis and delivery to lysosomes.|||Cell membrane|||Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.|||Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.|||Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8. Phosphorylated also by PKC; leading to the TCR complex down-regulation.|||The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. http://togogenome.org/gene/9541:RNASE13 ^@ http://purl.uniprot.org/uniprot/G7P9N1 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9541:FIGN ^@ http://purl.uniprot.org/uniprot/A0A2K5WYQ8|||http://purl.uniprot.org/uniprot/A0A8J8XP02 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9541:FABP3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTZ6|||http://purl.uniprot.org/uniprot/G7NWW7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:GTF2B ^@ http://purl.uniprot.org/uniprot/A0A805PTU9|||http://purl.uniprot.org/uniprot/Q4R3J5 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Autoacetylated; autoacetylation at Lys-238 stimulates transcription activation.|||Belongs to the TFIIB family.|||Chromosome|||Found in a ternary complex with TATA box-bound TBP. Part of a TFIID-containing RNA polymerase II pre-initiation complex (PIC) that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Associates with TFIID-TFIIA (DA complex) to form TFIID-TFIIA-TFIIB (DAB complex), which is then recognized by RNA polymerase II (Pol II). Found in a RNA polymerase II initiation complex. Interacts (via C-terminus) with TBP; this interaction with TATA box-bound TBP guides Pol II into the PIC. Interacts (via N-terminus) with Pol II. Interacts (via C-terminus) with SSU72; this interaction is inhibited by SYMPK. Interacts with NR2F1; this interaction is direct. Interacts with PGR. Interacts with ESR1. Interacts with GTF2F1 (via C-terminus and preferentially via acetylated form); this interaction prevents binding of GTF2B to GTF2F2. Interacts with GTF2F2 (via N-terminus); this interaction is inhibited in presence of GTF2F1. Interacts with the transcription elongation factor TCEA2. Interacts with HSF1 (via transactivation domain) (By similarity). Interacts with GPBP1 (By similarity).|||General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter-specific regions. Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element. Modulates transcription start site selection. Exhibits also autoacetyltransferase activity that contributes to the activated transcription.|||Nucleus|||The TFIIB-type zinc-binding domain is necessary for the interaction and recruitment of RNA polymerase II to the core promoter, the formation of a fully competent pre-initiation complex (PIC) assembly and basal transcription initiation. The C-terminus is necessary and sufficient for interaction with the TATA box-bound TBP complex and for the formation of PIC. http://togogenome.org/gene/9541:GDF10 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1X1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer.|||Secreted http://togogenome.org/gene/9541:AGPS ^@ http://purl.uniprot.org/uniprot/A0A2K5WE58 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family.|||Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.|||Homodimer.|||Peroxisome http://togogenome.org/gene/9541:TRPT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W375|||http://purl.uniprot.org/uniprot/G8F523 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate. http://togogenome.org/gene/9541:TEKT5 ^@ http://purl.uniprot.org/uniprot/Q4R353 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||May be a structural component of the sperm flagellum.|||flagellum http://togogenome.org/gene/9541:SLITRK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TP92|||http://purl.uniprot.org/uniprot/G7PVK2 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9541:SCGB1A1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YH17|||http://purl.uniprot.org/uniprot/G7PPU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the secretoglobin family.|||Secreted http://togogenome.org/gene/9541:RBM8A ^@ http://purl.uniprot.org/uniprot/A0A2K5VTA5|||http://purl.uniprot.org/uniprot/A0A8J8YI94|||http://purl.uniprot.org/uniprot/G7NTP9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBM8A family.|||Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.|||Cytoplasm|||Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.|||Nucleus|||Nucleus speckle http://togogenome.org/gene/9541:ZFPM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLG1|||http://purl.uniprot.org/uniprot/A0A2K5TLG8|||http://purl.uniprot.org/uniprot/A0A2K5TLH7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ERAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFR5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9541:STIM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1T5|||http://purl.uniprot.org/uniprot/A0A2K5X1T8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:MFSD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0Q1|||http://purl.uniprot.org/uniprot/G7PHU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Cell membrane|||Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.|||Membrane http://togogenome.org/gene/9541:PCSK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5J1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.|||Vesicle|||secretory vesicle http://togogenome.org/gene/9541:COL4A5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWY1|||http://purl.uniprot.org/uniprot/A0A2K5UWZ5|||http://purl.uniprot.org/uniprot/A0A7N9D7T3 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9541:RNPC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX42 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.|||Nucleus|||Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA. http://togogenome.org/gene/9541:LETM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LETM1 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:LOC102126012 ^@ http://purl.uniprot.org/uniprot/A0A2K5U824 ^@ Function|||Similarity ^@ Belongs to the MS4A family.|||May be involved in signal transduction as a component of a multimeric receptor complex. http://togogenome.org/gene/9541:ERBB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9541:EOGT ^@ http://purl.uniprot.org/uniprot/A0A2K5VXE4 ^@ Similarity ^@ Belongs to the glycosyltransferase 61 family. http://togogenome.org/gene/9541:KIF5B ^@ http://purl.uniprot.org/uniprot/A0A8J8XFK3|||http://purl.uniprot.org/uniprot/G7PEP7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:STOM ^@ http://purl.uniprot.org/uniprot/A0A2K5WET9 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9541:POLR3B ^@ http://purl.uniprot.org/uniprot/A0A2K5WM51|||http://purl.uniprot.org/uniprot/A0A8J8YGM6|||http://purl.uniprot.org/uniprot/G7PI40 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/9541:LOC102136392 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHY6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/9541:NUP58 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1M4|||http://purl.uniprot.org/uniprot/A0A2K5W1V1|||http://purl.uniprot.org/uniprot/Q4R7P1 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/9541:USP34 ^@ http://purl.uniprot.org/uniprot/A0A2K5VI37 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9541:MUC13 ^@ http://purl.uniprot.org/uniprot/A0A2K5WP68 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC102145356 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVA1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TBX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5E7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:NR5A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VL66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/9541:RNASE4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIU0|||http://purl.uniprot.org/uniprot/G7P9M0 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9541:SRP68 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP68 family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9541:LOC102121891 ^@ http://purl.uniprot.org/uniprot/A0A7N9DDS6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:TET3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VF07|||http://purl.uniprot.org/uniprot/A0A2K5VF81 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Chromosome|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/9541:CA5A ^@ http://purl.uniprot.org/uniprot/A0A7N9CDB0 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9541:SLC17A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U213|||http://purl.uniprot.org/uniprot/G7P2K5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NFX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WP81|||http://purl.uniprot.org/uniprot/A0A2K5WPJ0|||http://purl.uniprot.org/uniprot/A0A7N9CVF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NFX1 family.|||Nucleus http://togogenome.org/gene/9541:IFT22 ^@ http://purl.uniprot.org/uniprot/Q4R4K5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small GTPase superfamily. Rab family.|||Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88 (By similarity).|||Small GTPase-like component of the intraflagellar transport (IFT) complex B.|||cilium http://togogenome.org/gene/9541:MED13L ^@ http://purl.uniprot.org/uniprot/A0A2K5U2P3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 13 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9541:FLOT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXI3|||http://purl.uniprot.org/uniprot/A0A2K5WXI8|||http://purl.uniprot.org/uniprot/G8F5D3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Cell membrane|||Endosome|||Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.|||Heterooligomeric complex.|||May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.|||Membrane|||Membrane raft|||caveola http://togogenome.org/gene/9541:BRIX1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XBZ9|||http://purl.uniprot.org/uniprot/G7P7C2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BRX1 family.|||Required for biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/9541:POLR1A ^@ http://purl.uniprot.org/uniprot/A0A2K5WRU9|||http://purl.uniprot.org/uniprot/G8F3R2 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/9541:RFC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the activator 1 large subunit family.|||Nucleus http://togogenome.org/gene/9541:TIMM44 ^@ http://purl.uniprot.org/uniprot/I7GKB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tim44 family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:RDH5 ^@ http://purl.uniprot.org/uniprot/A0A8J8YRR1|||http://purl.uniprot.org/uniprot/G7PIF1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:UBE2N ^@ http://purl.uniprot.org/uniprot/Q4R4I1 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subunit ^@ Activity is inhibited by binding to OTUB1, which prevents 'Lys-63'-linked polyubiquitination.|||Belongs to the ubiquitin-conjugating enzyme family.|||Conjugation to ISG15 impairs formation of the thioester bond with ubiquitin but not interaction with UBE2V2.|||Heterodimer with UBE2V2. Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain); the complex has a specific 'Lys-63'-linked polyubiquitination activity. Interacts with RNF8 and RNF168. Interacts with RNF11. Interacts with the E3 ligases, HLTF and SHPRH; the interactions promote the 'Lys-63'-linked polyubiquitination of PCNA upon genotoxic stress and lead to DNA repair. Interacts with ARIH2 (via RING-type 2). Interacts with OTUB1; leading to inhibit E2-conjugating activity. Interacts with RIGI and RNF135; involved in RIGI ubiquitination and activation (By similarity).|||The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (By similarity). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. http://togogenome.org/gene/9541:SLC17A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5L8|||http://purl.uniprot.org/uniprot/A0A8J8YQC8|||http://purl.uniprot.org/uniprot/G7P2K8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CCR6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY45 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:CD164 ^@ http://purl.uniprot.org/uniprot/A0A2K5U491|||http://purl.uniprot.org/uniprot/A0A2K5U496|||http://purl.uniprot.org/uniprot/A0A7N9C9R9|||http://purl.uniprot.org/uniprot/A0A7N9ID13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane http://togogenome.org/gene/9541:TUBA4A ^@ http://purl.uniprot.org/uniprot/A0A2K5UF40|||http://purl.uniprot.org/uniprot/P68367 ^@ Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.|||Although this tubulin does not encode a C-terminal tyrosine, a C-terminal tyrosine can be added post-translationally by the tubulin tyrosine ligase (TTL). It can then undergo a detyrosination cycle by the tubulin tyrosine carboxypeptidase (KIAA0895L/MATCAP).|||Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with CFAP157 (By similarity).|||Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.|||Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (By similarity).|||Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility.|||The MREC motif may be critical for tubulin autoregulation.|||This tubulin does not have a C-terminal tyrosine.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9541:COQ9 ^@ http://purl.uniprot.org/uniprot/A0A7N9D679|||http://purl.uniprot.org/uniprot/I7G9A1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COQ9 family.|||Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.|||Mitochondrion http://togogenome.org/gene/9541:GRIA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWT7|||http://purl.uniprot.org/uniprot/A0A2K5TWV8|||http://purl.uniprot.org/uniprot/A0A2K5TWX3|||http://purl.uniprot.org/uniprot/G7PNL9|||http://purl.uniprot.org/uniprot/Q38PU5 ^@ Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily.|||Cell membrane|||Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with EPB41L1 via its C-terminus (By similarity). Found in a complex with GRIA1, GRIA2, GRIA3, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5 and PRKCG (By similarity).|||Membrane|||Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).|||Phosphorylated at Ser-862 by PRKCG; phosphorylation increases plasma membrane-associated GRI4 expression.|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).|||Synaptic cell membrane|||The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.|||The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.|||dendrite http://togogenome.org/gene/9541:TP53I11 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJK9|||http://purl.uniprot.org/uniprot/A0A7N9CI61 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GPT ^@ http://purl.uniprot.org/uniprot/A0A2K5VX98 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/9541:SLC1A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9541:FLVCR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X507|||http://purl.uniprot.org/uniprot/A0A7N9CV21|||http://purl.uniprot.org/uniprot/A0A7N9IDF1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:HPSE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W315 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/9541:NDRG1 ^@ http://purl.uniprot.org/uniprot/A0A805QPH7|||http://purl.uniprot.org/uniprot/Q4R4Q3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NDRG family.|||Cell membrane|||Interacts with RAB4A (membrane-bound form); the interaction involves NDRG1 in vesicular recycling ofCDH1. Interacts with APOA1, APOA2, PRA1 and RTN1 (By similarity).|||Nucleus|||Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking notably of the Schwann cell and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy (By similarity).|||Under stress conditions, phosphorylated in the C-terminal on many serine and threonine residues. Phosphorylated in vitro by PKA. Phosphorylation enhanced by increased intracellular cAMP levels. Homocysteine induces dephosphorylation. Phosphorylation by SGK1 is cell cycle dependent (By similarity).|||centrosome|||cytosol http://togogenome.org/gene/9541:HJV ^@ http://purl.uniprot.org/uniprot/A0A2K5TJX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:AOX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHA8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9541:SQSTM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5G6 ^@ Subcellular Location Annotation ^@ Lysosome|||autophagosome http://togogenome.org/gene/9541:UBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1K2|||http://purl.uniprot.org/uniprot/A0A2K5U1L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9541:LOC102139204 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4R6|||http://purl.uniprot.org/uniprot/G8F302 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Binds to bacterial lipopolysaccharides (LPS) and has antibacterial activity. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2.|||Secreted http://togogenome.org/gene/9541:RBBP8 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0D4|||http://purl.uniprot.org/uniprot/E5FGF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COM1/SAE2/CtIP family.|||Nucleus http://togogenome.org/gene/9541:LOC102142266 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGR2 ^@ Similarity ^@ Belongs to the FAM154 family. http://togogenome.org/gene/9541:MS4A4A ^@ http://purl.uniprot.org/uniprot/A0A2K5V5Y7 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9541:MRPL46 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL46 family.|||Mitochondrion http://togogenome.org/gene/9541:CYP27B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTY3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:GBA ^@ http://purl.uniprot.org/uniprot/A0A2K5UHW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 30 family.|||Lysosome membrane http://togogenome.org/gene/9541:TMEM131L ^@ http://purl.uniprot.org/uniprot/A0A2K5TXF2|||http://purl.uniprot.org/uniprot/A0A2K5TXH4 ^@ Similarity ^@ Belongs to the TMEM131 family. http://togogenome.org/gene/9541:NGLY1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSM0|||http://purl.uniprot.org/uniprot/A0A2K5WSR3|||http://purl.uniprot.org/uniprot/Q4R6F3 ^@ Activity Regulation|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transglutaminase-like superfamily. PNGase family.|||Binds 1 zinc ion per subunit.|||Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Interacts with the proteasome components RAD23B and PSMC1. Interacts with directly with VCP. Interacts with DERL1, bringing it close to the endoplasmic reticulum membrane. Interacts with SAKS1 (By similarity).|||Cytoplasm|||Inhibited by Z-VAD-fmk, a well-known caspase inhibitor, which inhibits enzyme activity through covalent binding of the carbohydrate to the single Cys-306 residue.|||Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity).|||Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.|||The PUB domain mediates the interaction with VCP. http://togogenome.org/gene/9541:NME7 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5S7|||http://purl.uniprot.org/uniprot/A0A7N9CSI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||cilium axoneme http://togogenome.org/gene/9541:LAP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7V5 ^@ Similarity|||Subunit ^@ Belongs to the peptidase M17 family.|||Homohexamer. http://togogenome.org/gene/9541:CACNB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||Cytoplasm http://togogenome.org/gene/9541:ACSS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1S4 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9541:VMA21 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYJ1|||http://purl.uniprot.org/uniprot/G7Q1X2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the V0 complex of the vacuolar ATPase (V-ATPase).|||Belongs to the VMA21 family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. http://togogenome.org/gene/9541:GTF2F1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9J0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF alpha subunit family.|||Nucleus|||TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. http://togogenome.org/gene/9541:GABPA ^@ http://purl.uniprot.org/uniprot/A0A8J8XLW7|||http://purl.uniprot.org/uniprot/G7P1M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:LOC102140054 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWI6 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/9541:GSTT2B ^@ http://purl.uniprot.org/uniprot/A0A023JCN4 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Theta family.|||Homodimer. http://togogenome.org/gene/9541:DUSP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2K0 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9541:NFIC ^@ http://purl.uniprot.org/uniprot/I7GL42 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/9541:KRT73 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQJ6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:AMPD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKN4 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Homotetramer. http://togogenome.org/gene/9541:MMP13 ^@ http://purl.uniprot.org/uniprot/A0A2K5U988 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.|||Secreted http://togogenome.org/gene/9541:SUPT16H ^@ http://purl.uniprot.org/uniprot/A0A2K5VAC8|||http://purl.uniprot.org/uniprot/G7P9N9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24 family. SPT16 subfamily.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Component of the FACT complex.|||Nucleus http://togogenome.org/gene/9541:GDPD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3D2|||http://purl.uniprot.org/uniprot/G7PUH0 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9541:AVL9 ^@ http://purl.uniprot.org/uniprot/A0A2K5USR4 ^@ Subcellular Location Annotation ^@ Endosome|||Recycling endosome http://togogenome.org/gene/9541:BABAM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYA8|||http://purl.uniprot.org/uniprot/A0A2K5VYD2|||http://purl.uniprot.org/uniprot/A0A7N9CLQ8|||http://purl.uniprot.org/uniprot/G7PLX8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BABAM2 family.|||Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.|||Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.|||Cytoplasm|||May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.|||Nucleus http://togogenome.org/gene/9541:GMPR ^@ http://purl.uniprot.org/uniprot/A0A2K5W3H2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/9541:CSTF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIM7|||http://purl.uniprot.org/uniprot/A0A2K5VIP5|||http://purl.uniprot.org/uniprot/G7Q380 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:S100A5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRQ8 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9541:NELFE ^@ http://purl.uniprot.org/uniprot/A0A2K5TSU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM NELF-E family.|||Chromosome|||Nucleus http://togogenome.org/gene/9541:YPEL1 ^@ http://purl.uniprot.org/uniprot/G7PHB3 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9541:LOC102118347 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKC3 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/9541:CDIPT ^@ http://purl.uniprot.org/uniprot/A0A2K5WDN2|||http://purl.uniprot.org/uniprot/G7Q0V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/9541:ADGRB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5USV2|||http://purl.uniprot.org/uniprot/A0A2K5USV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PPP4R2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ74|||http://purl.uniprot.org/uniprot/A0A2K5VZ88 ^@ Similarity ^@ Belongs to the PPP4R2 family. http://togogenome.org/gene/9541:POLR3H ^@ http://purl.uniprot.org/uniprot/A0A8J8YFK6|||http://purl.uniprot.org/uniprot/G7PFN5|||http://purl.uniprot.org/uniprot/I7GKA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9541:CCL28 ^@ http://purl.uniprot.org/uniprot/A0A8J8XBT9|||http://purl.uniprot.org/uniprot/G7P7G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:LOC102133222 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5C1|||http://purl.uniprot.org/uniprot/A0A2K5X5I7|||http://purl.uniprot.org/uniprot/A0A2K5X5J5|||http://purl.uniprot.org/uniprot/G7NYP7 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9541:FAM76B ^@ http://purl.uniprot.org/uniprot/A0A2K5VCW7 ^@ Similarity ^@ Belongs to the FAM76 family. http://togogenome.org/gene/9541:SET ^@ http://purl.uniprot.org/uniprot/A0A2K5U0J2|||http://purl.uniprot.org/uniprot/A0A2K5U0M4 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9541:OGN ^@ http://purl.uniprot.org/uniprot/A0A8J8XM09|||http://purl.uniprot.org/uniprot/G7PSP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.|||Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.|||extracellular matrix http://togogenome.org/gene/9541:PYY ^@ http://purl.uniprot.org/uniprot/A0A2K5TNU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/9541:EVL ^@ http://purl.uniprot.org/uniprot/A0A2K5U7D7|||http://purl.uniprot.org/uniprot/A0A2K5U7G2|||http://purl.uniprot.org/uniprot/A0A2K5U7I7|||http://purl.uniprot.org/uniprot/I7GNE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Ena/VASP family.|||Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.|||lamellipodium|||stress fiber http://togogenome.org/gene/9541:TWSG1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YIC6|||http://purl.uniprot.org/uniprot/G7PWD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the twisted gastrulation protein family.|||Secreted http://togogenome.org/gene/9541:SBDS ^@ http://purl.uniprot.org/uniprot/A0A2K5V3B1|||http://purl.uniprot.org/uniprot/G7P1P9 ^@ Function|||Similarity ^@ Belongs to the SDO1/SBDS family.|||Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. http://togogenome.org/gene/9541:PPIB ^@ http://purl.uniprot.org/uniprot/A0A2K5UAH0 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9541:TMPRSS11A ^@ http://purl.uniprot.org/uniprot/A0A2K5X3S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9541:FAM3B ^@ http://purl.uniprot.org/uniprot/A0A2K5X116 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9541:AHSA1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YKD1|||http://purl.uniprot.org/uniprot/G7PB34 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/9541:GLRB ^@ http://purl.uniprot.org/uniprot/A0A7N9CK22|||http://purl.uniprot.org/uniprot/A0A8J8XHE4|||http://purl.uniprot.org/uniprot/G7P6H0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:LOC102118714 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIT1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9541:AK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQR9|||http://purl.uniprot.org/uniprot/A0A2K5WR22|||http://purl.uniprot.org/uniprot/A0A7N9CVL8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK2 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Mitochondrion intermembrane space|||Monomer. http://togogenome.org/gene/9541:AHCY ^@ http://purl.uniprot.org/uniprot/Q4R596 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (By similarity). Binds copper ions (By similarity).|||Cytoplasm|||Homotetramer.|||Melanosome http://togogenome.org/gene/9541:AFAP1L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2P4|||http://purl.uniprot.org/uniprot/A0A2K5U2Q3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in podosome and invadosome formation.|||invadopodium|||podosome http://togogenome.org/gene/9541:CCNA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIK0|||http://purl.uniprot.org/uniprot/G7P675 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily. http://togogenome.org/gene/9541:DYNLRB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UM23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.|||cytoskeleton http://togogenome.org/gene/9541:NCDN ^@ http://purl.uniprot.org/uniprot/A0A2K5WEC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the neurochondrin family.|||Postsynapse http://togogenome.org/gene/9541:TREX1 ^@ http://purl.uniprot.org/uniprot/A0A7N9D4U6 ^@ Similarity ^@ Belongs to the exonuclease superfamily. TREX family. http://togogenome.org/gene/9541:MGAT4C ^@ http://purl.uniprot.org/uniprot/Q4R4A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 54 family.|||Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity) (By similarity).|||Golgi apparatus membrane http://togogenome.org/gene/9541:CDIP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9541:UPF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ20 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:ACYP2 ^@ http://purl.uniprot.org/uniprot/I7GL48 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/9541:PDE8B ^@ http://purl.uniprot.org/uniprot/A0A2K5VYA0 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:SHCBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEF9 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/9541:PLPPR4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VS40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9541:SLC26A6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WID5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:MRPS16 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZW1|||http://purl.uniprot.org/uniprot/G7PF15 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/9541:CLPS ^@ http://purl.uniprot.org/uniprot/G7P3A9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.|||Enterostatin has a biological activity as a satiety signal.|||Forms a 1:1 stoichiometric complex with pancreatic lipase.|||Secreted http://togogenome.org/gene/9541:MAPK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXF6 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.|||caveola http://togogenome.org/gene/9541:SYNE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNS7 ^@ Similarity ^@ Belongs to the nesprin family. http://togogenome.org/gene/9541:GET1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WT71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WRB/GET1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:FOLH1B ^@ http://purl.uniprot.org/uniprot/A0A2K5VNZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LAMA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDM9 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/9541:ITPRIPL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Membrane http://togogenome.org/gene/9541:PICK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCA7|||http://purl.uniprot.org/uniprot/G7PFE8 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.|||cytoskeleton|||perinuclear region|||synaptosome http://togogenome.org/gene/9541:INTS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIL5 ^@ Similarity ^@ Belongs to the Integrator subunit 3 family. http://togogenome.org/gene/9541:RIN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W717|||http://purl.uniprot.org/uniprot/A0A2K5W721|||http://purl.uniprot.org/uniprot/A0A2K5W777 ^@ Similarity ^@ Belongs to the RIN (Ras interaction/interference) family. http://togogenome.org/gene/9541:HBEGF ^@ http://purl.uniprot.org/uniprot/A0A2K5VHS5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:CXCL12 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9541:ATPAF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP12 family.|||Mitochondrion http://togogenome.org/gene/9541:RSBN1L ^@ http://purl.uniprot.org/uniprot/A0A2K5WLD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the round spermatid basic protein 1 family.|||Nucleus http://togogenome.org/gene/9541:OSBP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNB1 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9541:FRG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRG1 family.|||Cajal body|||nucleolus http://togogenome.org/gene/9541:FAM131C ^@ http://purl.uniprot.org/uniprot/A0A2K5W7W2 ^@ Similarity ^@ Belongs to the FAM131 family. http://togogenome.org/gene/9541:SLC24A5 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5C6|||http://purl.uniprot.org/uniprot/G7PV94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9541:SULT1E1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSM8|||http://purl.uniprot.org/uniprot/Q2XV97 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9541:CREB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X539|||http://purl.uniprot.org/uniprot/A0A7N9D5Y5|||http://purl.uniprot.org/uniprot/A0A8J8XE04|||http://purl.uniprot.org/uniprot/G7PLA3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TCEANC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2H7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SLC27A6 ^@ http://purl.uniprot.org/uniprot/A0A7N9CF54 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9541:PRKRIP1 ^@ http://purl.uniprot.org/uniprot/I7GKW9 ^@ Similarity ^@ Belongs to the PRKRIP1 family. http://togogenome.org/gene/9541:MMP24 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJD5 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9541:BOLA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTT7|||http://purl.uniprot.org/uniprot/A0A7N9CWH0 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/9541:RANBP17 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:ATP13A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7Z4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Membrane http://togogenome.org/gene/9541:GDAP1L1 ^@ http://purl.uniprot.org/uniprot/Q4R514 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/9541:NDE1 ^@ http://purl.uniprot.org/uniprot/I7GC55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||kinetochore|||spindle http://togogenome.org/gene/9541:ZMYM5 ^@ http://purl.uniprot.org/uniprot/Q4R3D6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Functions as a transcriptional regulator.|||Interacts (via N-terminal 120 amino acid region) with ETV5 (via C-terminal).|||Nucleus http://togogenome.org/gene/9541:ITGAV ^@ http://purl.uniprot.org/uniprot/A0A2K5WC83|||http://purl.uniprot.org/uniprot/A0A2K5WCD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9541:LIPE ^@ http://purl.uniprot.org/uniprot/B0I549 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 'GDXG' lipolytic enzyme family.|||Cell membrane|||Lipid droplet|||caveola|||cytosol http://togogenome.org/gene/9541:PGAP3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CNG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP3 family.|||Golgi apparatus membrane|||Involved in the lipid remodeling steps of GPI-anchor maturation.|||Membrane http://togogenome.org/gene/9541:NOL10 ^@ http://purl.uniprot.org/uniprot/A0A8J8YFH0|||http://purl.uniprot.org/uniprot/G7PLL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat NOL10/ENP2 family.|||nucleolus http://togogenome.org/gene/9541:CRTC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WS70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TORC family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:POLR2E ^@ http://purl.uniprot.org/uniprot/A0A8J8Y181|||http://purl.uniprot.org/uniprot/G7PYA0|||http://purl.uniprot.org/uniprot/I7GDN8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.|||Nucleus http://togogenome.org/gene/9541:PORCN ^@ http://purl.uniprot.org/uniprot/A0A2K5VCC3|||http://purl.uniprot.org/uniprot/A0A2K5VCF0|||http://purl.uniprot.org/uniprot/A0A2K5VCF9|||http://purl.uniprot.org/uniprot/G7Q2M6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:UVSSA ^@ http://purl.uniprot.org/uniprot/A0A2K5VRL8 ^@ Similarity ^@ Belongs to the UVSSA family. http://togogenome.org/gene/9541:RXRG ^@ http://purl.uniprot.org/uniprot/A0A8J8XR23|||http://purl.uniprot.org/uniprot/G7NU27 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Homodimer. Heterodimer; with a rar molecule.|||Nucleus|||Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. http://togogenome.org/gene/9541:EXTL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWW7|||http://purl.uniprot.org/uniprot/A0A2K5UX31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:SCNN1B ^@ http://purl.uniprot.org/uniprot/A0A2K5TNB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/9541:CEP19 ^@ http://purl.uniprot.org/uniprot/A0A7N9IDV7|||http://purl.uniprot.org/uniprot/A0A8J8XSK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP19 family.|||centriole|||cilium basal body|||spindle pole http://togogenome.org/gene/9541:TAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5P0 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. http://togogenome.org/gene/9541:FAM162A ^@ http://purl.uniprot.org/uniprot/A0A2K5UWZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0389 family.|||Membrane http://togogenome.org/gene/9541:TAAR2 ^@ http://purl.uniprot.org/uniprot/G7P352 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:MBOAT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0Q0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:B3GALNT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U945 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:LOC102121603 ^@ http://purl.uniprot.org/uniprot/A0A2K5TM51 ^@ Similarity ^@ Belongs to the vasopressin/oxytocin family. http://togogenome.org/gene/9541:SLC24A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UX63|||http://purl.uniprot.org/uniprot/A0A2K5UX84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9541:FAM13B ^@ http://purl.uniprot.org/uniprot/A0A2K5X716|||http://purl.uniprot.org/uniprot/A0A2K5X739|||http://purl.uniprot.org/uniprot/A0A2K5X7D0|||http://purl.uniprot.org/uniprot/G7P8D3 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9541:SNRNP27 ^@ http://purl.uniprot.org/uniprot/A0A7N9DFU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNUT3 family.|||May play a role in mRNA splicing.|||Nucleus|||Part of a tri-snRNP complex. http://togogenome.org/gene/9541:LOC102146329 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8J1 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:RPL22 ^@ http://purl.uniprot.org/uniprot/I7GHE4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/9541:CFAP97D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8Q6 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/9541:TMTC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKT3|||http://purl.uniprot.org/uniprot/A0A8J8XP16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9541:RSL24D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1F9|||http://purl.uniprot.org/uniprot/G7PBI5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/9541:AKAP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEG8 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/9541:PIGS ^@ http://purl.uniprot.org/uniprot/A0A8J8YJ93|||http://purl.uniprot.org/uniprot/G7PTX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGS family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:FMO3 ^@ http://purl.uniprot.org/uniprot/A0A023JCA1|||http://purl.uniprot.org/uniprot/A0A2K5X3X3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.|||Microsome membrane http://togogenome.org/gene/9541:ICAM3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/9541:FAM124A ^@ http://purl.uniprot.org/uniprot/A0A2K5UNR3 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/9541:NDUFS3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XXC2|||http://purl.uniprot.org/uniprot/G7PQ90 ^@ Similarity ^@ Belongs to the complex I 30 kDa subunit family. http://togogenome.org/gene/9541:DPH5 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5Q4|||http://purl.uniprot.org/uniprot/G7NV35 ^@ Function|||Similarity ^@ Belongs to the diphthine synthase family.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/9541:TUBA1A ^@ http://purl.uniprot.org/uniprot/I7G2D1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/9541:PIK3CA ^@ http://purl.uniprot.org/uniprot/A0A8J8XAB5|||http://purl.uniprot.org/uniprot/G7NZ32 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9541:CYP4F3 ^@ http://purl.uniprot.org/uniprot/A8CBR6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:SLC5A7 ^@ http://purl.uniprot.org/uniprot/A0A8J8YA03|||http://purl.uniprot.org/uniprot/G7PMW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9541:TXNRD2 ^@ http://purl.uniprot.org/uniprot/Q2PFY4 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/9541:SGMS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9541:LBX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFD2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NKAIN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHB5|||http://purl.uniprot.org/uniprot/G7P387 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LMOD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVK9 ^@ Subcellular Location Annotation ^@ cytoskeleton|||sarcomere http://togogenome.org/gene/9541:HSPA14 ^@ http://purl.uniprot.org/uniprot/G7PEF0|||http://purl.uniprot.org/uniprot/Q4R6J2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.|||Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (By similarity).|||Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.|||cytosol http://togogenome.org/gene/9541:ARSG ^@ http://purl.uniprot.org/uniprot/A0A2K5UHF4 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9541:LOC102120132 ^@ http://purl.uniprot.org/uniprot/Q4W7C7 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9541:RPL27A ^@ http://purl.uniprot.org/uniprot/I7G9Y0|||http://purl.uniprot.org/uniprot/Q4R723 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm|||Hydroxylated on His-39 by MINA. http://togogenome.org/gene/9541:ZFYVE9 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0B7|||http://purl.uniprot.org/uniprot/A0A2K5X0C8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Early endosome membrane http://togogenome.org/gene/9541:TMA16 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3M7|||http://purl.uniprot.org/uniprot/A0A7N9CQM1 ^@ Function|||Similarity|||Subunit ^@ Associates with pre-60S ribosomal particles.|||Belongs to the TMA16 family.|||Involved in the biogenesis of the 60S ribosomal subunit in the nucleus. http://togogenome.org/gene/9541:PEX10 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJN1|||http://purl.uniprot.org/uniprot/Q8HXW8 ^@ Activity Regulation|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pex2/pex10/pex12 family.|||Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12. Interacts with PEX19.|||E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (By similarity). When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity).|||Peroxisome membrane|||Somewhat implicated in the biogenesis of peroxisomes.|||The E3 ubiquitin-protein ligase activity is stimulated by PEX12.|||The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore. The RING-type zinc-fingers that catalyze PEX5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex. http://togogenome.org/gene/9541:SPDYE4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMF6 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/9541:DNAH7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJ98 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/9541:SLC26A7 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/9541:FGF6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9Z0 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:PLXNA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5J3|||http://purl.uniprot.org/uniprot/A0A2K5X619 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:ITM2B ^@ http://purl.uniprot.org/uniprot/Q60HC1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ITM2 family.|||Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.|||Cell membrane|||Endosome membrane|||Glycosylation at Asn-170 is important for cell surface localization, but doesn't affect furin- and ADAM10-induced proteolytic processing.|||Golgi apparatus membrane|||Homodimer; disulfide-linked. Interacts with SPPL2A and SPPL2B. Interacts with APP. Mature BRI2 (mBRI2) interacts with the APP amyloid-beta A4 protein; the interaction occurs at the cell surface and in the endocytic compartments and enable alpha- and beta-secretase-induced APP cleavage inhibition. Mature BRI2 (mBRI2) interacts with the APP C99; the interaction occurs in the endocytic compartments and enable gamma-secretase-induced C99 cleavage inhibition. May form heterodimers with Bri23 peptide and APP amyloid-beta protein 40 (By similarity).|||Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42.|||Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity).|||Secreted|||The ectodomain C-terminal part of the imBRI2 is processed by furin producing a secreted Bri23 peptide and a mature BRI2, membrane form (mBRI2). The remaining part of the ectodomain of mBRI2 containing the BRICHOS domain is cleaved by ADAM10 and is secreted (BRI2C, soluble form). The membrane-bound N-terminal fragment (BRI2C, membrane form) is further proteolytically processed by SPPL2A and SPPL2B through regulated intramembrane proteolysis producing a secreted C-peptide and a BRI2 intracellular domain (BRI2 ICD) released in the cytosol. Shedding by ADAM10 facilitates intramembrane cleavage but is not absolutely required for BRI2 ICD generation (By similarity). http://togogenome.org/gene/9541:FAM32A ^@ http://purl.uniprot.org/uniprot/A0A8J8XI49|||http://purl.uniprot.org/uniprot/G7PZQ2 ^@ Similarity ^@ Belongs to the FAM32 family. http://togogenome.org/gene/9541:GMPPA ^@ http://purl.uniprot.org/uniprot/A0A2K5VWY8|||http://purl.uniprot.org/uniprot/G7PK50|||http://purl.uniprot.org/uniprot/I7GH22 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/9541:TMEM184B ^@ http://purl.uniprot.org/uniprot/A0A7N9D347|||http://purl.uniprot.org/uniprot/A0A8J8YHY8|||http://purl.uniprot.org/uniprot/G7PFF1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:BNIP3L ^@ http://purl.uniprot.org/uniprot/A0A7N9CUL1|||http://purl.uniprot.org/uniprot/I7G855 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIP3 family.|||Membrane http://togogenome.org/gene/9541:LOC102139603 ^@ http://purl.uniprot.org/uniprot/A0A2K5X026 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lambda interferon family.|||Secreted http://togogenome.org/gene/9541:SLC16A13 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEG7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:APEX2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0B6|||http://purl.uniprot.org/uniprot/G7Q2U4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/9541:EVC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIS7 ^@ Subcellular Location Annotation ^@ Membrane|||cilium basal body|||cilium membrane http://togogenome.org/gene/9541:SLC5A6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9541:UTRN ^@ http://purl.uniprot.org/uniprot/A0A2K5U6J0 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:LGALSL ^@ http://purl.uniprot.org/uniprot/A0A2K5UYR9 ^@ Function ^@ Does not bind lactose, and may not bind carbohydrates. http://togogenome.org/gene/9541:LOC102138871 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJS7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9541:LOC102130747 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYD0|||http://purl.uniprot.org/uniprot/G7Q275|||http://purl.uniprot.org/uniprot/I7GNR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:MTIF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQM6|||http://purl.uniprot.org/uniprot/A0A7N9CHK0 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/9541:CD74 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6J1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ATP5MF ^@ http://purl.uniprot.org/uniprot/Q2PFS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase F chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:DHRS9 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPG0|||http://purl.uniprot.org/uniprot/G7PKR5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:RPGRIP1L ^@ http://purl.uniprot.org/uniprot/A0A2K5VF28 ^@ Similarity ^@ Belongs to the RPGRIP1 family. http://togogenome.org/gene/9541:CSRNP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL50|||http://purl.uniprot.org/uniprot/A0A2K5WL57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/9541:ELP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VE95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP1/IKA1 family.|||Cytoplasm http://togogenome.org/gene/9541:SLC4A8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDS8|||http://purl.uniprot.org/uniprot/A0A2K5VDT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Membrane http://togogenome.org/gene/9541:LAMA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VU44 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ATG9A ^@ http://purl.uniprot.org/uniprot/A0A8J8YEM8|||http://purl.uniprot.org/uniprot/G7PK41 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/9541:DARS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEA8|||http://purl.uniprot.org/uniprot/G7PN28 ^@ Function|||Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. http://togogenome.org/gene/9541:TFDP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9541:APOE ^@ http://purl.uniprot.org/uniprot/A2V9Z3 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9541:TBCA ^@ http://purl.uniprot.org/uniprot/Q4R3H4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCA family.|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.|||Tubulin-folding protein; involved in the early step of the tubulin folding pathway.|||cytoskeleton http://togogenome.org/gene/9541:SLC66A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFU5|||http://purl.uniprot.org/uniprot/A0A2K5UFU7|||http://purl.uniprot.org/uniprot/A0A2K5UFX7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NDUFS7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 20 kDa subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:TBC1D24 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWN6|||http://purl.uniprot.org/uniprot/A0A2K5VWS7 ^@ Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Cytoplasmic vesicle membrane|||Interacts with ARF6.|||Membrane|||Presynapse|||Synapse http://togogenome.org/gene/9541:LRP8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU88|||http://purl.uniprot.org/uniprot/A0A2K5UU97|||http://purl.uniprot.org/uniprot/A0A2K5UUH0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PRIMPOL ^@ http://purl.uniprot.org/uniprot/A0A2K5X7L5|||http://purl.uniprot.org/uniprot/G7P6M9 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/9541:SGSH ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ56 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9541:PAX8 ^@ http://purl.uniprot.org/uniprot/A0A2K5X834 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NELFCD ^@ http://purl.uniprot.org/uniprot/Q4R7U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NELF-D family.|||Nucleus http://togogenome.org/gene/9541:NSUN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPT4 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9541:RPL17 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPE4|||http://purl.uniprot.org/uniprot/I7GNZ8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9541:MTFR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1R7|||http://purl.uniprot.org/uniprot/G7PBX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/9541:LETMD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAU8|||http://purl.uniprot.org/uniprot/A0A2K5VAY4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CD47 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4H8|||http://purl.uniprot.org/uniprot/A0A2K5X4I2|||http://purl.uniprot.org/uniprot/A0A2K5X523 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:CALHM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6X0|||http://purl.uniprot.org/uniprot/G7PDW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9541:NCAPD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W497 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CND1 (condensin subunit 1) family.|||Chromosome|||Nucleus|||Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. http://togogenome.org/gene/9541:RPIA ^@ http://purl.uniprot.org/uniprot/A0A2K5USK7 ^@ Similarity ^@ Belongs to the ribose 5-phosphate isomerase family. http://togogenome.org/gene/9541:LAMP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKF4|||http://purl.uniprot.org/uniprot/A0A8J8YC93|||http://purl.uniprot.org/uniprot/G7Q3L7|||http://purl.uniprot.org/uniprot/Q4R5B5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lysosome membrane http://togogenome.org/gene/9541:PLXNA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8T0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PRR5L ^@ http://purl.uniprot.org/uniprot/A0A7N9CVR5|||http://purl.uniprot.org/uniprot/A0A7N9DDG5 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/9541:CDC42SE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W700 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.|||Membrane|||Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.|||cytoskeleton http://togogenome.org/gene/9541:PRDM16 ^@ http://purl.uniprot.org/uniprot/A0A2K5TM59 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NXT2 ^@ http://purl.uniprot.org/uniprot/G7Q3G2|||http://purl.uniprot.org/uniprot/I7GLF0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/9541:WAS ^@ http://purl.uniprot.org/uniprot/A0A2K5U1L0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SMARCAD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1P6|||http://purl.uniprot.org/uniprot/A0A2K5W1R0 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9541:SLC10A7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCL6|||http://purl.uniprot.org/uniprot/A0A2K5UCM4|||http://purl.uniprot.org/uniprot/A0A2K5UCN6|||http://purl.uniprot.org/uniprot/A0A2K5UCN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Cell membrane|||Does not show transport activity towards bile acids or steroid sulfates.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/9541:FAM168A ^@ http://purl.uniprot.org/uniprot/A0A2K5U445|||http://purl.uniprot.org/uniprot/A0A8J8XHB5|||http://purl.uniprot.org/uniprot/G7PN71 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/9541:ESR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2L5|||http://purl.uniprot.org/uniprot/A0A8J8Y5F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9541:ST7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UL64|||http://purl.uniprot.org/uniprot/A0A2K5UL81|||http://purl.uniprot.org/uniprot/A0A2K5UL95|||http://purl.uniprot.org/uniprot/A0A2K5ULV5|||http://purl.uniprot.org/uniprot/Q2PG42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/9541:HAPLN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMZ9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:IRF6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5G7|||http://purl.uniprot.org/uniprot/A0A8J8XYR9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:LOC102144280 ^@ http://purl.uniprot.org/uniprot/Q25QC0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:TMCC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNR5|||http://purl.uniprot.org/uniprot/A0A2K5WNR7 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9541:HK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9C8 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9541:COPS3 ^@ http://purl.uniprot.org/uniprot/G7PTS0|||http://purl.uniprot.org/uniprot/Q4R898 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSN3 family.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo (By similarity).|||Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (By similarity). In the complex, it probably interacts directly with COPS1, COPS4, COPS8 and COPS9 (By similarity). Interacts with CK2 and PKD (By similarity). Interacts with the translation initiation factor EIF3S6 and IKBKG (By similarity). Interacts with ERCC6 (By similarity).|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:DTWD2 ^@ http://purl.uniprot.org/uniprot/Q4R7M4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TDD superfamily. DTWD2 family.|||Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)). Also has a weak activity to form acp3U at position 20 in the D-loop of tRNAs (acp3U(20)).|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:NDUFC2 ^@ http://purl.uniprot.org/uniprot/G7PNB6|||http://purl.uniprot.org/uniprot/Q8SPI4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis but required for the complex assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFC2 subunit family.|||Complex I is composed of 45 different subunits. Interacts with TMEM242 (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ATP5MC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VR53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9541:NOP16 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP16 family.|||nucleolus http://togogenome.org/gene/9541:DAB1 ^@ http://purl.uniprot.org/uniprot/Q9BGX5 ^@ Domain|||Function|||PTM|||Subunit ^@ Adapter molecule functioning in neural development. May regulate SIAH1 activity.|||Associates with the SH2 domains of SRC, FYN and ABL. Interacts (phosphorylated on tyrosine residues) with CRK and CRKL (via respective SH2 domain). Interacts with DAB2IP, SIAH1, LRP8 and VLDLR. Interacts with LRP1. Interacts with APLP1 (via NPXY motif). Interacts with DAB2IP (By similarity).|||Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also phosphorylated on Ser-491 independently of reelin signaling.|||The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins. http://togogenome.org/gene/9541:LOC101864872 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNF2 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9541:ELF3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YH53|||http://purl.uniprot.org/uniprot/G7NWE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:ELF5 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0W6|||http://purl.uniprot.org/uniprot/G7PQE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:B3GALT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y920|||http://purl.uniprot.org/uniprot/G7PKQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:LOC102136362 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4L0 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/9541:SLC9A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJH0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.|||Membrane http://togogenome.org/gene/9541:GABRA3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YAB1|||http://purl.uniprot.org/uniprot/G7Q1Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:DDX47 ^@ http://purl.uniprot.org/uniprot/A0A2K5W149|||http://purl.uniprot.org/uniprot/G7PJW4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily. http://togogenome.org/gene/9541:RUNX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXE3 ^@ Function|||Subcellular Location Annotation ^@ Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.|||Nucleus http://togogenome.org/gene/9541:SUMO2 ^@ http://purl.uniprot.org/uniprot/Q2PFW2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Cleavage of precursor form by SENP1 or SENP2 is necessary for function.|||Interacts with SAE2 and UBE2I. Interacts with ZNF451. Identified in a complex with ZNF451 and UBE2I/UBC9, where one ZNF451 interacts with one UBE2I/UBC9 and two SUMO2 chains, one bound to the UBE2I/UBC9 active site and the other to another region of the same UBE2I/UBC9 molecule. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 and SOBP (via SIM domains). Interacts with MTA1 (By similarity). Interacts with HINT1 (By similarity). Interacts with GCNA (via SIM domains); this interaction allows the GCNA recruitment to DPCs sites (By similarity).|||Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitination by the UBE2V1-UBE2N heterodimer.|||Nucleus|||PML body|||Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4 (By similarity).|||Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity). http://togogenome.org/gene/9541:DNAJB12 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFF1|||http://purl.uniprot.org/uniprot/G7PF24 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:MED10 ^@ http://purl.uniprot.org/uniprot/Q4R6W4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 10 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).|||Nucleus http://togogenome.org/gene/9541:LOC102146098 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHV9 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9541:BUD31 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTI5|||http://purl.uniprot.org/uniprot/G7P0A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/9541:FAM53C ^@ http://purl.uniprot.org/uniprot/A0A8J8XQE5|||http://purl.uniprot.org/uniprot/G7P8E1 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/9541:CAPN13 ^@ http://purl.uniprot.org/uniprot/A0A2K5UC73 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9541:ALDH18A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7W0|||http://purl.uniprot.org/uniprot/G7PDM0 ^@ Similarity ^@ In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.|||In the N-terminal section; belongs to the glutamate 5-kinase family. http://togogenome.org/gene/9541:GPRC5D ^@ http://purl.uniprot.org/uniprot/A0A2K5W6I7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:PTPRU ^@ http://purl.uniprot.org/uniprot/A0A2K5TWR7|||http://purl.uniprot.org/uniprot/A0A2K5TWT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.|||Membrane http://togogenome.org/gene/9541:TRIM5 ^@ http://purl.uniprot.org/uniprot/B1Q3L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Nucleus http://togogenome.org/gene/9541:ADAMTS9 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5E0|||http://purl.uniprot.org/uniprot/A0A2K5U5H5 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:WWOX ^@ http://purl.uniprot.org/uniprot/A0A2K5W5D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm http://togogenome.org/gene/9541:SNCB ^@ http://purl.uniprot.org/uniprot/A0A2K5TQK0 ^@ Similarity ^@ Belongs to the synuclein family. http://togogenome.org/gene/9541:GRIK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2V7|||http://purl.uniprot.org/uniprot/A0A2K5X344|||http://purl.uniprot.org/uniprot/A0A2K5X351|||http://purl.uniprot.org/uniprot/Q38PU4 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily.|||Cell membrane|||Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers (Probable). The unedited version (Q) assembles into a functional kainate-gated homomeric channel, whereas the edited version (R) is unable to produce channel activity when expressed alone. Both edited and unedited versions can form functional channels with GRIK4 and GRIK5. Interacts with KLHL17 (By similarity).|||Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus (By similarity).|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane|||The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate > L-glutamate = quisqualate > CNQX = DNQX > AMPA > dihydrokainate > NMDA (By similarity). http://togogenome.org/gene/9541:RBFOX3 ^@ http://purl.uniprot.org/uniprot/I7GM52 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||RNA-binding protein that regulates alternative splicing events. http://togogenome.org/gene/9541:SVOPL ^@ http://purl.uniprot.org/uniprot/A0A2K5TNH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9541:LOC102143165 ^@ http://purl.uniprot.org/uniprot/A0A8J8YAT7|||http://purl.uniprot.org/uniprot/G7PQY2 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9541:TRAF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W360 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9541:LOC102138598 ^@ http://purl.uniprot.org/uniprot/Q9BEH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9541:CCL1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y905|||http://purl.uniprot.org/uniprot/G7PU26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:CLASP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLASP family.|||centrosome|||kinetochore|||trans-Golgi network http://togogenome.org/gene/9541:LSM4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU92 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/9541:SEC61G ^@ http://purl.uniprot.org/uniprot/A0A2K5X404|||http://purl.uniprot.org/uniprot/G7P1R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:SLC16A10 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ50 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:MICOS10 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ97 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic10 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ASIC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/9541:AQP6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W965 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9541:A4GNT ^@ http://purl.uniprot.org/uniprot/A0A2K5VVL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 32 family.|||Golgi apparatus membrane http://togogenome.org/gene/9541:ZC3H12B ^@ http://purl.uniprot.org/uniprot/A0A2K5VYZ7 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/9541:ICAM5 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/9541:CLDN9 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCC0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:SAA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VN00 ^@ Function|||Similarity ^@ Belongs to the SAA family.|||Major acute phase reactant. Apolipoprotein of the HDL complex. http://togogenome.org/gene/9541:DIPK1A ^@ http://purl.uniprot.org/uniprot/A0A2K5X6R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:BRINP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNH3|||http://purl.uniprot.org/uniprot/G7NXE7 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9541:ARHGEF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNA5|||http://purl.uniprot.org/uniprot/Q9N0A8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.|||Cytoplasm|||Interacts with RHOA and RHOB. http://togogenome.org/gene/9541:UNC5B ^@ http://purl.uniprot.org/uniprot/A0A2K5VIP2|||http://purl.uniprot.org/uniprot/A0A2K5VIX7|||http://purl.uniprot.org/uniprot/A0A2K5VJ03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9541:DLX3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YFU8|||http://purl.uniprot.org/uniprot/G7PU96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/9541:LOC102122876 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJ68 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CASK ^@ http://purl.uniprot.org/uniprot/A0A2K5VCX7 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9541:HTRA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9C7 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/9541:DDX3X ^@ http://purl.uniprot.org/uniprot/A0A2K5UCB3|||http://purl.uniprot.org/uniprot/G7Q2J2 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9541:COCH ^@ http://purl.uniprot.org/uniprot/A0A2K5VH24 ^@ Function ^@ Plays a role in the control of cell shape and motility in the trabecular meshwork. http://togogenome.org/gene/9541:TMEM208 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1G1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.|||Membrane http://togogenome.org/gene/9541:TTC21A ^@ http://purl.uniprot.org/uniprot/A0A2K5WR01 ^@ Similarity ^@ Belongs to the TTC21 family. http://togogenome.org/gene/9541:CNOT11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT11 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:NEU2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKC0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/9541:SLC25A20 ^@ http://purl.uniprot.org/uniprot/Q8HXY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Mediates the electroneutral exchange of acylcarnitines (O-acyl-(R)-carnitine or L-acylcarnitine) of different acyl chain lengths (ranging from O-acetyl-(R)-carnitine to long-chain O-acyl-(R)-carnitines) with free carnitine ((R)-carnitine or L-carnitine) across the mitochondrial inner membrane, via a ping-pong mechanism. Key player in the mitochondrial oxidation pathway, it translocates the fatty acids in the form of acylcarnitines into the mitochondrial matrix, where the carnitine palmitoyltransferase 2 (CPT-2) activates them to undergo fatty acid beta-oxidation. Catalyzes the unidirectional transport (uniport) of carnitine at lower rates than the antiport (exchange).|||Mitochondrion inner membrane http://togogenome.org/gene/9541:RMI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFH3|||http://purl.uniprot.org/uniprot/G7PSL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RMI1 family.|||Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.|||Nucleus http://togogenome.org/gene/9541:CACNA1D ^@ http://purl.uniprot.org/uniprot/A0A2K5X3X8|||http://purl.uniprot.org/uniprot/A0A2K5X401|||http://purl.uniprot.org/uniprot/A0A2K5X464|||http://purl.uniprot.org/uniprot/G7NZU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.|||Membrane|||Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. http://togogenome.org/gene/9541:SRSF2 ^@ http://purl.uniprot.org/uniprot/Q4R7A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the splicing factor SR family.|||Nucleus http://togogenome.org/gene/9541:YKT6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBR5|||http://purl.uniprot.org/uniprot/A0A2K5VBW3|||http://purl.uniprot.org/uniprot/A0A7N9IDJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. http://togogenome.org/gene/9541:LOC102115229 ^@ http://purl.uniprot.org/uniprot/C0SJM3 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9541:ELOVL4 ^@ http://purl.uniprot.org/uniprot/Q95K73 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the ELO family. ELOVL4 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.|||Endoplasmic reticulum membrane|||Expressed mainly in retina. Also expressed in skin and thymus.|||N-glycosylated.|||Oligomer.|||The C-terminal di-lysine motif confers endoplasmic reticulum localization. http://togogenome.org/gene/9541:PTMA ^@ http://purl.uniprot.org/uniprot/A0A2K5UTL9|||http://purl.uniprot.org/uniprot/Q9BE93 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9541:CENPJ ^@ http://purl.uniprot.org/uniprot/A0A2K5X6K0 ^@ Similarity ^@ Belongs to the TCP10 family. http://togogenome.org/gene/9541:PSKH1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YA10|||http://purl.uniprot.org/uniprot/G7Q1F3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:RNF121 ^@ http://purl.uniprot.org/uniprot/I7GI74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TSC22D3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6V2|||http://purl.uniprot.org/uniprot/A0A8J8Y7S0|||http://purl.uniprot.org/uniprot/G7Q3E9 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9541:XIRP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9T7|||http://purl.uniprot.org/uniprot/A0A2K5U9V2 ^@ Domain|||Function|||Similarity ^@ Belongs to the Xin family.|||Protects actin filaments from depolymerization.|||Xin repeats bind F-actin. http://togogenome.org/gene/9541:SLC7A9 ^@ http://purl.uniprot.org/uniprot/A0A8J8YMC4|||http://purl.uniprot.org/uniprot/G7PX58 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LVRN ^@ http://purl.uniprot.org/uniprot/A0A2K5VM02 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9541:FAM3A ^@ http://purl.uniprot.org/uniprot/A0A2K5VW74|||http://purl.uniprot.org/uniprot/A0A2K5VWI0|||http://purl.uniprot.org/uniprot/A0A2K5VWK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9541:TNFRSF1A ^@ http://purl.uniprot.org/uniprot/Q2PFV5 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:KCNE3 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULE3|||http://purl.uniprot.org/uniprot/G7PN85 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9541:AP2M1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJU4|||http://purl.uniprot.org/uniprot/A0A7N9CQ19|||http://purl.uniprot.org/uniprot/Q4R706 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). Interacts with ATP6V1H and MEGF10. Interacts with EGFR. Interacts with F2R. Interacts with PIP5K1C; tyrosine phosphorylation of PIP5K1C weakens the interaction. Interacts with KIAA0319; required for clathrin-mediated endocytosis of KIAA0319 (By similarity). Interacts with DVL2 (via DEP domain) (By similarity). Interacts with KCNQ1; mediates estrogen-induced internalization via clathrin-coated vesicles (By similarity). Together with AP2A1 or AP2A2 and AP2B1, it interacts with ADAM10; this interaction facilitates ADAM10 endocytosis from the plasma membrane during long-term potentiation in hippocampal neurons (By similarity). Interacts with RALBP1; the interaction is direct (By similarity). Interacts with TMEM106B (via N-terminus) (By similarity).|||Belongs to the adaptor complexes medium subunit family.|||Cell membrane|||Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface (By similarity). AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules (By similarity). AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (By similarity). The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs (By similarity). The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at Thr-156 in membrane-associated AP-2. The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (By similarity). Plays a role in endocytosis of frizzled family members upon Wnt signaling (By similarity).|||Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.|||Phosphorylation at Thr-156 increases the affinity of the AP-2 complex for cargo membrane proteins during the initial stages of endocytosis.|||coated pit http://togogenome.org/gene/9541:INTS10 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2N7|||http://purl.uniprot.org/uniprot/A0A2K5X2N9|||http://purl.uniprot.org/uniprot/A0A2K5X373 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 10 family.|||Nucleus http://togogenome.org/gene/9541:SERPINE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHR4|||http://purl.uniprot.org/uniprot/G7PK70 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:HMBS ^@ http://purl.uniprot.org/uniprot/G7PP48 ^@ Similarity ^@ Belongs to the HMBS family. http://togogenome.org/gene/9541:SPARCL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UV59 ^@ Similarity ^@ Belongs to the SPARC family. http://togogenome.org/gene/9541:KRT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U960 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:SMIM22 ^@ http://purl.uniprot.org/uniprot/A0A8J8YC88|||http://purl.uniprot.org/uniprot/G7Q0F0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NETO2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8V7|||http://purl.uniprot.org/uniprot/A0A2K5X9A8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ARID5B ^@ http://purl.uniprot.org/uniprot/A0A2K5W2A4 ^@ Similarity ^@ Belongs to the ARID5B family. http://togogenome.org/gene/9541:CLVS1 ^@ http://purl.uniprot.org/uniprot/I7G4C9 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Vesicle|||clathrin-coated vesicle|||trans-Golgi network membrane http://togogenome.org/gene/9541:PTP4A1 ^@ http://purl.uniprot.org/uniprot/Q9TSM6 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the protein-tyrosine phosphatase family.|||Cell membrane|||Cytoplasm|||Early endosome|||Endoplasmic reticulum|||Farnesylated. Farnesylation is required for membrane targeting (By similarity).|||Homotrimer. Interacts with ATF5 and tubulin (By similarity).|||In the retina, expressed by red/green- but not blue-sensitive cone photoreceptor cells, and by rod bipolar cells (at protein level).|||Inhibited by sodium orthovanadate and pentamidine.|||Nucleus|||Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity).|||spindle http://togogenome.org/gene/9541:BST1 ^@ http://purl.uniprot.org/uniprot/E5G6H5|||http://purl.uniprot.org/uniprot/I7GP78 ^@ Similarity ^@ Belongs to the ADP-ribosyl cyclase family. http://togogenome.org/gene/9541:GPSM2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYJ0|||http://purl.uniprot.org/uniprot/G7NV46|||http://purl.uniprot.org/uniprot/I7GBU4 ^@ Similarity ^@ Belongs to the GPSM family. http://togogenome.org/gene/9541:P2RX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTF7|||http://purl.uniprot.org/uniprot/A0A2K5UTI0|||http://purl.uniprot.org/uniprot/A0A2K5UTI8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9541:MTMR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9541:RPRM ^@ http://purl.uniprot.org/uniprot/A0A2K5UIX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the reprimo family.|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:ST14 ^@ http://purl.uniprot.org/uniprot/A0A2K5V642 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S1 family.|||Degrades extracellular matrix.|||Interacts with CDCP1. May interact with TMEFF1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PPP3CA ^@ http://purl.uniprot.org/uniprot/A0A2K5WC95 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/9541:MED1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WR27 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 1 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9541:FIBIN ^@ http://purl.uniprot.org/uniprot/A0A7N9CYV4|||http://purl.uniprot.org/uniprot/G8F334 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FIBIN family.|||Endoplasmic reticulum|||Golgi apparatus|||Homodimer; disulfide-linked. Seems to also exist as monomers.|||Secreted http://togogenome.org/gene/9541:TMEM35A ^@ http://purl.uniprot.org/uniprot/G7Q386|||http://purl.uniprot.org/uniprot/Q4R5F4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DoxX family.|||Cytoplasmic vesicle|||Endoplasmic reticulum membrane|||May interact with NGFR (By similarity). Interacts with RPN1, RPN2 and CANX (By similarity).|||Membrane|||Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain (By similarity). Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors (By similarity). Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (By similarity). Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly (By similarity). Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form (By similarity).|||Peroxisome membrane|||Vesicle http://togogenome.org/gene/9541:TM9SF1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJG6|||http://purl.uniprot.org/uniprot/G7P9Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9541:PKNOX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSL6|||http://purl.uniprot.org/uniprot/A0A8J8XRF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9541:SLC22A12 ^@ http://purl.uniprot.org/uniprot/I7GVA8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SLC25A26 ^@ http://purl.uniprot.org/uniprot/A0A2K5X9J2|||http://purl.uniprot.org/uniprot/I7GN77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:CTSZ ^@ http://purl.uniprot.org/uniprot/A0A2K5U716 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9541:MED15 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNG5|||http://purl.uniprot.org/uniprot/A0A2K5TNH4|||http://purl.uniprot.org/uniprot/A0A2K5TNI9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 15 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9541:DMC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VU11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. DMC1 subfamily.|||May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.|||Nucleus http://togogenome.org/gene/9541:NXPH4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W074 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||Secreted http://togogenome.org/gene/9541:LOC102128774 ^@ http://purl.uniprot.org/uniprot/G7P6U9|||http://purl.uniprot.org/uniprot/Q76KA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL32 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm http://togogenome.org/gene/9541:NAPSA ^@ http://purl.uniprot.org/uniprot/A0A2K5U456 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Secreted http://togogenome.org/gene/9541:THEMIS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5URH2|||http://purl.uniprot.org/uniprot/A0A2K5URI2 ^@ Similarity ^@ Belongs to the themis family. http://togogenome.org/gene/9541:ASB12 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y3T4|||http://purl.uniprot.org/uniprot/G7Q2W5 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:IP6K3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQF7 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9541:SLC66A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPR6|||http://purl.uniprot.org/uniprot/A0A2K5WPV1|||http://purl.uniprot.org/uniprot/A0A2K5WQ60 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GSTM3 ^@ http://purl.uniprot.org/uniprot/G8F3A6|||http://purl.uniprot.org/uniprot/Q2PFL7 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Mu family.|||Homodimer. http://togogenome.org/gene/9541:ALDH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ28 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9541:EFHB ^@ http://purl.uniprot.org/uniprot/A0A2K5UL59 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9541:NES ^@ http://purl.uniprot.org/uniprot/A0A2K5UJT4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:RNH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAH7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.|||Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. http://togogenome.org/gene/9541:MAPRE3 ^@ http://purl.uniprot.org/uniprot/I7GK68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/9541:PSIP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YF26|||http://purl.uniprot.org/uniprot/G7PSB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HDGF family.|||Nucleus http://togogenome.org/gene/9541:MAPK8IP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKM3|||http://purl.uniprot.org/uniprot/A0A2K5TKP3 ^@ Similarity ^@ Belongs to the JIP scaffold family. http://togogenome.org/gene/9541:CDH9 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8N6|||http://purl.uniprot.org/uniprot/G7P7A8 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CCND2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YNL4|||http://purl.uniprot.org/uniprot/G7PJL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin D subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:TNFRSF14 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0Q5|||http://purl.uniprot.org/uniprot/A0A2K5W0R1|||http://purl.uniprot.org/uniprot/A0A7N9CGR4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:SGIP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VU08|||http://purl.uniprot.org/uniprot/A0A2K5VU63 ^@ Function|||Subcellular Location Annotation ^@ May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.|||clathrin-coated pit http://togogenome.org/gene/9541:ADORA2A ^@ http://purl.uniprot.org/uniprot/G7PHD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/9541:PEX13 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-13 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9541:SLC25A30 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAN4|||http://purl.uniprot.org/uniprot/A0A2K5VAR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:FKBP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7V4 ^@ Subcellular Location Annotation ^@ Mitochondrion|||Nucleus|||cytoskeleton|||cytosol http://togogenome.org/gene/9541:FAR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1G0|||http://purl.uniprot.org/uniprot/A0A7N9I9D4|||http://purl.uniprot.org/uniprot/I7GNX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acyl-CoA reductase family.|||Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.|||Peroxisome membrane http://togogenome.org/gene/9541:SLC46A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4B4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CCL17 ^@ http://purl.uniprot.org/uniprot/A0A2K5UW77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:HSD17B2 ^@ http://purl.uniprot.org/uniprot/Q4JK76 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:ETV4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W104|||http://purl.uniprot.org/uniprot/A0A2K5W122 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:ME1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WN61 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/9541:LAPTM4A ^@ http://purl.uniprot.org/uniprot/G7PLP2|||http://purl.uniprot.org/uniprot/Q4R4I5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAPTM4/LAPTM5 transporter family.|||Endomembrane system|||May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.|||The C-terminal domain is necessary for retention within intracellular membranes. http://togogenome.org/gene/9541:MMP16 ^@ http://purl.uniprot.org/uniprot/A0A8J8YC73|||http://purl.uniprot.org/uniprot/G7PC63 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9541:GMNN ^@ http://purl.uniprot.org/uniprot/A0A2K5UXU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/9541:MZF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNA6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NAP1L2 ^@ http://purl.uniprot.org/uniprot/G8F2R5 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9541:LOC102115611 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5H2 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/9541:GALNT10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:ERLIN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5URK3|||http://purl.uniprot.org/uniprot/A0A7N9CRK4|||http://purl.uniprot.org/uniprot/A0A8J8YHC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the band 7/mec-2 family.|||Endoplasmic reticulum membrane|||Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.|||Membrane http://togogenome.org/gene/9541:ACTR5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family. ARP5 subfamily.|||Nucleus http://togogenome.org/gene/9541:CCNE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJW9 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin E subfamily. http://togogenome.org/gene/9541:TPM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXJ1|||http://purl.uniprot.org/uniprot/A0A2K5TXJ6|||http://purl.uniprot.org/uniprot/A0A2K5TXK7|||http://purl.uniprot.org/uniprot/G7PS00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9541:BTAF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VR83|||http://purl.uniprot.org/uniprot/A0A2K5VRB0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:EXOSC9 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR67 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:SGO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||centromere http://togogenome.org/gene/9541:BIRC7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VS62 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/9541:TRPV2 ^@ http://purl.uniprot.org/uniprot/A0A2K5USU2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TMEM165 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GDT1 family.|||Membrane http://togogenome.org/gene/9541:LOC101865393 ^@ http://purl.uniprot.org/uniprot/A0A8J8YNH3|||http://purl.uniprot.org/uniprot/G7PU91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tdpoz family.|||Nucleus speckle http://togogenome.org/gene/9541:NECAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U244|||http://purl.uniprot.org/uniprot/A0A2K5U268|||http://purl.uniprot.org/uniprot/A0A2K5U270|||http://purl.uniprot.org/uniprot/G8F5M0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9541:TASOR ^@ http://purl.uniprot.org/uniprot/A0A2K5TY11 ^@ Similarity ^@ Belongs to the TASOR family. http://togogenome.org/gene/9541:FAM83F ^@ http://purl.uniprot.org/uniprot/A0A2K5TX34 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9541:STEAP4 ^@ http://purl.uniprot.org/uniprot/G7P1V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9541:OCEL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VL12 ^@ Similarity ^@ Belongs to the ELL/occludin family. http://togogenome.org/gene/9541:MAX ^@ http://purl.uniprot.org/uniprot/Q4R7R4 ^@ Similarity ^@ Belongs to the MAX family. http://togogenome.org/gene/9541:CHGB ^@ http://purl.uniprot.org/uniprot/A0A2K5TKE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/9541:IDO2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WW66 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/9541:LOC102117823 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQM8|||http://purl.uniprot.org/uniprot/A0A2K5TQR4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:VGLL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8U7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs.|||Nucleus http://togogenome.org/gene/9541:CRIPT ^@ http://purl.uniprot.org/uniprot/A0A2K5U226|||http://purl.uniprot.org/uniprot/G7PM54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRIPT family.|||Cytoplasm http://togogenome.org/gene/9541:SLC7A6OS ^@ http://purl.uniprot.org/uniprot/A0A2K5WV80 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IWR1/SLC7A6OS family.|||Cytoplasm|||Directs RNA polymerase II nuclear import.|||Nucleus http://togogenome.org/gene/9541:LOC102124401 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIW7 ^@ Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 22 family.|||Monomer. http://togogenome.org/gene/9541:PTK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUX1 ^@ Subcellular Location Annotation ^@ Cell membrane|||cell cortex|||focal adhesion http://togogenome.org/gene/9541:SUV39H1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYD7|||http://purl.uniprot.org/uniprot/A0A2K5VYE5|||http://purl.uniprot.org/uniprot/A0A7N9CQR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Nucleus|||centromere http://togogenome.org/gene/9541:EIF5A ^@ http://purl.uniprot.org/uniprot/A0A2K5WME8|||http://purl.uniprot.org/uniprot/A0A2K5WMF8|||http://purl.uniprot.org/uniprot/G8F5Y2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Membrane|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.|||mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. http://togogenome.org/gene/9541:KPNA2 ^@ http://purl.uniprot.org/uniprot/Q4R6K6 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9541:CPLX4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X485 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9541:SIAH3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZY6|||http://purl.uniprot.org/uniprot/G7PW59 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9541:DEFB116 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:SCAMP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9541:SMCO2 ^@ http://purl.uniprot.org/uniprot/Q95JR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:BCHE ^@ http://purl.uniprot.org/uniprot/D4P3V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Secreted http://togogenome.org/gene/9541:CHL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5H2|||http://purl.uniprot.org/uniprot/A0A2K5U5I6|||http://purl.uniprot.org/uniprot/A0A2K5U5L5|||http://purl.uniprot.org/uniprot/A0A2K5U5M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.|||Membrane http://togogenome.org/gene/9541:ING2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4J7|||http://purl.uniprot.org/uniprot/A0A7N9CZX0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9541:LOC102135041 ^@ http://purl.uniprot.org/uniprot/Q4R4W6 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9541:F13B ^@ http://purl.uniprot.org/uniprot/A0A2K5TS80 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:CACNG7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAN9|||http://purl.uniprot.org/uniprot/G7PYR3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. http://togogenome.org/gene/9541:GSTP1 ^@ http://purl.uniprot.org/uniprot/A0A023JCR5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GST superfamily. Pi family.|||Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.|||Cytoplasm|||Homodimer.|||Mitochondrion|||Nucleus http://togogenome.org/gene/9541:PROX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ70|||http://purl.uniprot.org/uniprot/A0A7N9C9H6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:C4H6orf58 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LEG1 family.|||Secreted http://togogenome.org/gene/9541:CFLAR ^@ http://purl.uniprot.org/uniprot/A0A2K5W001|||http://purl.uniprot.org/uniprot/A0A2K5W047 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9541:TSPAN10 ^@ http://purl.uniprot.org/uniprot/A0A2K5US98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:CNPY2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDB9 ^@ Similarity ^@ Belongs to the canopy family. http://togogenome.org/gene/9541:SORBS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCB8|||http://purl.uniprot.org/uniprot/A0A2K5WCG3|||http://purl.uniprot.org/uniprot/A0A2K5WCG7 ^@ Subcellular Location Annotation ^@ focal adhesion http://togogenome.org/gene/9541:CENPC ^@ http://purl.uniprot.org/uniprot/A0A2K5UH11 ^@ Similarity ^@ Belongs to the CENP-C/MIF2 family. http://togogenome.org/gene/9541:ARF3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CGG1|||http://purl.uniprot.org/uniprot/G8F594|||http://purl.uniprot.org/uniprot/Q2PG54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9541:PABIR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TY75|||http://purl.uniprot.org/uniprot/A0A2K5TY82|||http://purl.uniprot.org/uniprot/A0A7N9CUL9|||http://purl.uniprot.org/uniprot/A0A7N9D5Q1|||http://purl.uniprot.org/uniprot/G7Q1R0|||http://purl.uniprot.org/uniprot/I7G675 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/9541:LYG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZA1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 23 family. http://togogenome.org/gene/9541:GRIK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6H7|||http://purl.uniprot.org/uniprot/A0A2K5X6J9|||http://purl.uniprot.org/uniprot/A0A2K5X6L2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9541:MRPL33 ^@ http://purl.uniprot.org/uniprot/A0A2K5W679 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/9541:MED4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2M7|||http://purl.uniprot.org/uniprot/I7G8W5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 4 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9541:SLC2A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKN2|||http://purl.uniprot.org/uniprot/A0A7N9CLG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:MAN2A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9X7|||http://purl.uniprot.org/uniprot/A0A2K5V9Y2 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9541:PDLIM3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1J5|||http://purl.uniprot.org/uniprot/A0A2K5U1K1 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/9541:LOC102143686 ^@ http://purl.uniprot.org/uniprot/A0A7N9CJD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane http://togogenome.org/gene/9541:SMARCB1 ^@ http://purl.uniprot.org/uniprot/I7GMY5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNF5 family.|||Component of the multiprotein chromatin-remodeling complexes SWI/SNF.|||Nucleus http://togogenome.org/gene/9541:ACADL ^@ http://purl.uniprot.org/uniprot/A0A7N9D315|||http://purl.uniprot.org/uniprot/G7PLB9|||http://purl.uniprot.org/uniprot/Q60HI0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-318 and Lys-322 in proximity of the cofactor-binding sites strongly reduces catalytic activity. These sites are deacetylated by SIRT3.|||Belongs to the acyl-CoA dehydrogenase family.|||Homotetramer.|||Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains (By similarity).|||Mitochondrion matrix http://togogenome.org/gene/9541:PLAC8 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7H6 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9541:NAPRT ^@ http://purl.uniprot.org/uniprot/A0A2K5X066 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/9541:PPA2 ^@ http://purl.uniprot.org/uniprot/Q4R5Y3 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/9541:LOC102123375 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUC1|||http://purl.uniprot.org/uniprot/A0A2K5WUC7|||http://purl.uniprot.org/uniprot/A0A2K5WUK0 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9541:BAIAP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX11 ^@ Similarity ^@ Belongs to the unc-13 family. http://togogenome.org/gene/9541:CAD ^@ http://purl.uniprot.org/uniprot/A0A2K5TQU2 ^@ Similarity ^@ In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. http://togogenome.org/gene/9541:CD180 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMK8|||http://purl.uniprot.org/uniprot/A0A2K5VMS6 ^@ Similarity ^@ Belongs to the Toll-like receptor family. http://togogenome.org/gene/9541:GPBAR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC2 family.|||Cell projection|||Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton|||synaptosome http://togogenome.org/gene/9541:USP10 ^@ http://purl.uniprot.org/uniprot/A0A2K5W874 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP10 subfamily.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus http://togogenome.org/gene/9541:ADAM10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCL9|||http://purl.uniprot.org/uniprot/A0A2K5WCT6 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||adherens junction http://togogenome.org/gene/9541:SGTA ^@ http://purl.uniprot.org/uniprot/A0A2K5WG51 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/9541:TULP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZZ0|||http://purl.uniprot.org/uniprot/A0A2K5U007|||http://purl.uniprot.org/uniprot/A0A2K5U043 ^@ Similarity ^@ Belongs to the TUB family. http://togogenome.org/gene/9541:ASAH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEH4|||http://purl.uniprot.org/uniprot/G7PDG4 ^@ Similarity ^@ Belongs to the neutral ceramidase family. http://togogenome.org/gene/9541:GBX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2H8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PIH1D2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFW9 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9541:CD82 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAB1|||http://purl.uniprot.org/uniprot/G7PQC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:ITGB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Membrane http://togogenome.org/gene/9541:LOC102142787 ^@ http://purl.uniprot.org/uniprot/Q2PFP9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.|||Belongs to the 7B2 family.|||Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.|||Secreted http://togogenome.org/gene/9541:GAD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VV10 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9541:LOC102123270 ^@ http://purl.uniprot.org/uniprot/G7P5I5|||http://purl.uniprot.org/uniprot/Q4R648 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIb family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:HNRNPK ^@ http://purl.uniprot.org/uniprot/A0A2K5TNW0|||http://purl.uniprot.org/uniprot/A0A2K5TNX2|||http://purl.uniprot.org/uniprot/Q4R4M6 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Identified in the spliceosome C complex. Interacts with ANKRD28, RBM42 and ZIK1. Interacts with DDX1. Interacts with MDM2; this interaction leads to ubiquitination and proteasomal degradation. Interacts with p53/TP53. Interacts with BRDT (By similarity). Interacts with IVNS1ABP (By similarity). Interacts with PPIA/CYPA (By similarity). Part of a transcription inhibitory ribonucleoprotein complex composed at least of the circular RNA circZNF827, ZNF827 and HNRNPL (By similarity).|||O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.|||One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest (By similarity). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity).|||Sumoylated by CBX4. Sumoylation is increased upon DNA damage, such as that produced by doxorubicin, etoposide, UV light and camptothecin, due to enhanced CBX4 phosphorylation by HIPK2 under these conditions (By similarity).|||Ubiquitinated by MDM2. Doxorubicin treatment does not affect monoubiquitination, but slightly decreases HNRNPK poly-ubiquitination (By similarity).|||nucleoplasm|||podosome http://togogenome.org/gene/9541:DUOXA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V323 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DUOXA family.|||Membrane http://togogenome.org/gene/9541:MAT2B ^@ http://purl.uniprot.org/uniprot/A0A2K5VAN0|||http://purl.uniprot.org/uniprot/A0A2K5VAR3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.|||Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.|||Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. http://togogenome.org/gene/9541:MS4A7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ04 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9541:RPS18 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0I8 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. http://togogenome.org/gene/9541:NR2C2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSH1|||http://purl.uniprot.org/uniprot/A0A7N9DFG1|||http://purl.uniprot.org/uniprot/A0A7N9ICD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:F5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJA4 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9541:PPOX ^@ http://purl.uniprot.org/uniprot/A0A8J8XJT1|||http://purl.uniprot.org/uniprot/G7NXA3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.|||Binds 1 FAD per subunit.|||Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:LOC101925094 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZL4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members.|||Nucleus|||Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation. In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes. Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation. In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening. http://togogenome.org/gene/9541:CAND1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y752|||http://purl.uniprot.org/uniprot/G7PHZ3 ^@ Similarity ^@ Belongs to the CAND family. http://togogenome.org/gene/9541:IRF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3M1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:PRLR ^@ http://purl.uniprot.org/uniprot/A0A2K5WXK1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.|||Membrane|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation.|||This is a receptor for the anterior pituitary hormone prolactin. http://togogenome.org/gene/9541:ETV2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:FXYD4 ^@ http://purl.uniprot.org/uniprot/A0A7N9DEE3|||http://purl.uniprot.org/uniprot/A0A8J8YJX1|||http://purl.uniprot.org/uniprot/G7PER3 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/9541:XYLT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFW7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 14 family. XylT subfamily.|||Golgi apparatus membrane|||Membrane|||Monomer. http://togogenome.org/gene/9541:ADAT1 ^@ http://purl.uniprot.org/uniprot/Q4R7N3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ADAT1 family.|||Binds 1 myo-inositol hexakisphosphate (IP6) per subunit.|||Specifically deaminates adenosine-37 to inosine in tRNA-Ala. http://togogenome.org/gene/9541:GNPNAT1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CA22 ^@ Similarity|||Subunit ^@ Belongs to the acetyltransferase family. GNA1 subfamily.|||Homodimer. http://togogenome.org/gene/9541:IL33 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3I1|||http://purl.uniprot.org/uniprot/A0A2K5W3N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family. Highly divergent.|||Chromosome|||Nucleus|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/9541:RPS15 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXU9|||http://purl.uniprot.org/uniprot/A0A7N9ICI6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS19 family. http://togogenome.org/gene/9541:AWAT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTH0|||http://purl.uniprot.org/uniprot/G7Q2Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:PIM2 ^@ http://purl.uniprot.org/uniprot/I7GP26 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.|||Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. http://togogenome.org/gene/9541:ZFHX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WF45 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CKAP2L ^@ http://purl.uniprot.org/uniprot/A0A2K5ULJ7 ^@ Similarity ^@ Belongs to the CKAP2 family. http://togogenome.org/gene/9541:HAPLN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFA9|||http://purl.uniprot.org/uniprot/I7G8A1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:NMNAT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUX4 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9541:SUPT20H ^@ http://purl.uniprot.org/uniprot/A0A2K5UYR2|||http://purl.uniprot.org/uniprot/A0A2K5UYT4|||http://purl.uniprot.org/uniprot/A0A2K5UYW4 ^@ Similarity ^@ Belongs to the SPT20 family. http://togogenome.org/gene/9541:SMC5 ^@ http://purl.uniprot.org/uniprot/G7PSI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC5 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9541:MYC ^@ http://purl.uniprot.org/uniprot/G7PCT8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9541:NOP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||nucleolus http://togogenome.org/gene/9541:BBS5 ^@ http://purl.uniprot.org/uniprot/G7PKR7|||http://purl.uniprot.org/uniprot/Q4R649 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BBS5 family.|||Cytoplasm|||Membrane|||Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10 (By similarity). Binds to phosphoinositides (By similarity). Interacts with CCDC28B. Interacts with SMO; the interaction is indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO (By similarity). Interacts with PKD1 (By similarity). Interacts with DLEC1 (By similarity).|||Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly (By similarity).|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.|||centriolar satellite|||cilium basal body|||cilium membrane http://togogenome.org/gene/9541:HNRNPH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0Q6 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/9541:SLC9B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1Y1|||http://purl.uniprot.org/uniprot/G8F3G6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LCA5L ^@ http://purl.uniprot.org/uniprot/A0A8J8YMB0|||http://purl.uniprot.org/uniprot/G7P0Z6 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/9541:ATP6V1G2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V321|||http://purl.uniprot.org/uniprot/G7P4N9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9541:CAMK2B ^@ http://purl.uniprot.org/uniprot/Q4R5P8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9541:MLH3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIA1|||http://purl.uniprot.org/uniprot/A0A2K5VIE7|||http://purl.uniprot.org/uniprot/A0A2K5VIG7 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/9541:GTF2F2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF beta subunit family.|||Nucleus|||TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. http://togogenome.org/gene/9541:NSMCE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVU3|||http://purl.uniprot.org/uniprot/A0A2K5VW03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE1 family.|||Component of the Smc5-Smc6 complex.|||Nucleus|||RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.|||telomere http://togogenome.org/gene/9541:RAE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VF96|||http://purl.uniprot.org/uniprot/G7PFT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat rae1 family.|||spindle pole http://togogenome.org/gene/9541:IPO4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAA3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:TUBAL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W052 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/9541:ALDH5A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VL23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).|||Homotetramer.|||Mitochondrion http://togogenome.org/gene/9541:SLC7A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TND9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:RPL28 ^@ http://purl.uniprot.org/uniprot/I7GMU4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL28 family. http://togogenome.org/gene/9541:GNAZ ^@ http://purl.uniprot.org/uniprot/A0A2K5WQN4 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9541:PPM1K ^@ http://purl.uniprot.org/uniprot/A0A8J8YE78|||http://purl.uniprot.org/uniprot/G7P5W4 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9541:PFDN4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPQ5|||http://purl.uniprot.org/uniprot/G7PFU5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/9541:SARS1 ^@ http://purl.uniprot.org/uniprot/Q4R4U9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule may bind across the dimer. Interacts with SIRT2. Interacts with METTL6; interaction is required for the tRNA N(3)-methylcytidine methyltransferase activity of METTL6.|||Nucleus http://togogenome.org/gene/9541:FITM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMP8|||http://purl.uniprot.org/uniprot/G7PGB9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:PDE3B ^@ http://purl.uniprot.org/uniprot/A0A2K5VHT9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:LPCAT4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1Q3 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9541:KDELR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKI0|||http://purl.uniprot.org/uniprot/I7GLV4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:NINJ2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDG0|||http://purl.uniprot.org/uniprot/A0A2K5UDG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ninjurin family.|||Membrane http://togogenome.org/gene/9541:SLC31A2 ^@ http://purl.uniprot.org/uniprot/A0A7N9DHW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Membrane http://togogenome.org/gene/9541:ZDHHC22 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXY5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:GJA5 ^@ http://purl.uniprot.org/uniprot/A0A8J8YEV8|||http://purl.uniprot.org/uniprot/G7NTQ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9541:TATDN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VL58 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/9541:DUT ^@ http://purl.uniprot.org/uniprot/A0A2K5U4P0|||http://purl.uniprot.org/uniprot/A0A2K5U4P8|||http://purl.uniprot.org/uniprot/I7GP54 ^@ Function|||Similarity ^@ Belongs to the dUTPase family.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/9541:SH3GL1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CJM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Early endosome membrane|||Endosome membrane|||Implicated in endocytosis. May recruit other proteins to membranes with high curvature.|||Membrane http://togogenome.org/gene/9541:ST6GAL1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CJR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:CLPX ^@ http://purl.uniprot.org/uniprot/A0A2K5V0Y7|||http://purl.uniprot.org/uniprot/A0A2K5V120|||http://purl.uniprot.org/uniprot/A0A2K5V141 ^@ Similarity ^@ Belongs to the ClpX chaperone family. http://togogenome.org/gene/9541:NTMT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ61 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/9541:SDHAF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLA7|||http://purl.uniprot.org/uniprot/Q9GMX8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SDHAF2 family.|||Interacts with SDHA within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. http://togogenome.org/gene/9541:LMF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lipase maturation factor family.|||Endoplasmic reticulum membrane|||Involved in the maturation of specific proteins in the endoplasmic reticulum.|||Membrane http://togogenome.org/gene/9541:STARD6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WR44 ^@ Function ^@ May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. http://togogenome.org/gene/9541:SYCP3 ^@ http://purl.uniprot.org/uniprot/Q4R764 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XLR/SYCP3 family.|||Chromosome|||Component of the lateral elements of synaptonemal complexes (By similarity). Homotetramer; the tetrameric helix bundles assemble end to end into long homopolimeric fibers that exhibit a transversal striation with a periodicity of about 20 nm (in vitro) (By similarity). Interacts with SYCP2 (By similarity). Forms a complex with EWSR1, PRDM9, REC8 and SYCP1; complex formation is dependent of phosphorylated form of REC8 and requires PRDM9 bound to hotspot DNA; EWSR1 joins PRDM9 with the chromosomal axis through REC8 (By similarity).|||Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2.|||Composed of a long central coiled coil domain. The N-terminal and C-terminal regions interact with DNA.|||Nucleus|||Phosphorylated.|||centromere http://togogenome.org/gene/9541:CCDC65 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8W7 ^@ Subcellular Location Annotation|||Subunit ^@ Component of the nexin-dynein regulatory complex (N-DRC).|||flagellum axoneme http://togogenome.org/gene/9541:PARP11 ^@ http://purl.uniprot.org/uniprot/A0A2K5U101|||http://purl.uniprot.org/uniprot/A0A2K5U114|||http://purl.uniprot.org/uniprot/A0A2K5U124 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9541:MRPL15 ^@ http://purl.uniprot.org/uniprot/A0A8J8XH12|||http://purl.uniprot.org/uniprot/G7PBU7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/9541:C5H4orf47 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0602 family.|||centrosome http://togogenome.org/gene/9541:P2RX4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUE4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9541:RAB38 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQF5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9541:FOXO4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YHY7|||http://purl.uniprot.org/uniprot/G7Q2Z4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:THUMPD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQ92 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9541:SUCLG1 ^@ http://purl.uniprot.org/uniprot/I7GHF0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. http://togogenome.org/gene/9541:HMOX2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YHX2|||http://purl.uniprot.org/uniprot/G7Q0E3|||http://purl.uniprot.org/uniprot/Q2PG53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme oxygenase family.|||Endoplasmic reticulum|||Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.|||Microsome http://togogenome.org/gene/9541:DCAF10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VV60|||http://purl.uniprot.org/uniprot/A0A2K5VV63 ^@ Function|||Similarity ^@ Belongs to the WD repeat DCAF10 family.|||May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. http://togogenome.org/gene/9541:CNKSR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TS39 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/9541:RGN ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0M3|||http://purl.uniprot.org/uniprot/G7Q2K7|||http://purl.uniprot.org/uniprot/Q2PFX5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMP-30/CGR1 family.|||Binds 1 divalent metal cation per subunit. Most active with Zn(2+) and Mn(2+) ions. The physiological cofactor is most likely Ca(2+) or Mg(2+).|||Cytoplasm|||Gluconolactonase catalyzes a key step in ascorbic acid (vitamin C) biosynthesis, but primates lack the last enzyme in the pathway and are unable to synthesize vitamin C.|||Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).|||Monomer. http://togogenome.org/gene/9541:F2RL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQC9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:HOXB6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9541:UHRF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJF1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:BICD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJZ5|||http://purl.uniprot.org/uniprot/A0A2K5TK20|||http://purl.uniprot.org/uniprot/A0A7N9CYZ3 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/9541:DDX6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0J2 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9541:METTL4 ^@ http://purl.uniprot.org/uniprot/G7PWG2 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/9541:ELOVL6 ^@ http://purl.uniprot.org/uniprot/A0A7N9D0S2 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL6 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-Glycosylated. http://togogenome.org/gene/9541:FAM47A ^@ http://purl.uniprot.org/uniprot/A0A7N9CS05 ^@ Similarity ^@ Belongs to the FAM47 family. http://togogenome.org/gene/9541:SLC1A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9541:SLC41A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAN1|||http://purl.uniprot.org/uniprot/A0A2K5WAS0|||http://purl.uniprot.org/uniprot/A0A8J8XXE9|||http://purl.uniprot.org/uniprot/G7NYE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9541:NCK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQ82 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/9541:MVK ^@ http://purl.uniprot.org/uniprot/A0A2K5W7N6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.|||Cytoplasm http://togogenome.org/gene/9541:LOC102132314 ^@ http://purl.uniprot.org/uniprot/A0A2K5UE86 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:CCNB2 ^@ http://purl.uniprot.org/uniprot/Q4R7A8 ^@ Developmental Stage|||Function|||Similarity|||Subunit ^@ Accumulates steadily during G2 and is abruptly destroyed at mitosis.|||Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex (By similarity). http://togogenome.org/gene/9541:WNT8A ^@ http://purl.uniprot.org/uniprot/A0A2K5VSI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:SLC26A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCG1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Cell membrane|||Membrane|||Sulfate transporter. May play a role in endochondral bone formation. http://togogenome.org/gene/9541:TCN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9541:PCBD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U618 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/9541:GRIN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5USM9|||http://purl.uniprot.org/uniprot/A0A2K5USV1|||http://purl.uniprot.org/uniprot/A0A2K5UT02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:NHS ^@ http://purl.uniprot.org/uniprot/A0A2K5TNF8 ^@ Similarity ^@ Belongs to the NHS family. http://togogenome.org/gene/9541:DTX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TM11|||http://purl.uniprot.org/uniprot/A0A2K5TM17|||http://purl.uniprot.org/uniprot/A0A7N9DG46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/9541:IL6 ^@ http://purl.uniprot.org/uniprot/G7P0R5|||http://purl.uniprot.org/uniprot/P79341 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability. Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF. Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (By similarity). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis. Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (By similarity). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).|||Belongs to the IL-6 superfamily.|||Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST. Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling. Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation. May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling.|||Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.|||IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (By similarity). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity).|||Secreted http://togogenome.org/gene/9541:FGF17 ^@ http://purl.uniprot.org/uniprot/A0A2K5V360 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:FAM120C ^@ http://purl.uniprot.org/uniprot/A0A2K5W2T6 ^@ Similarity ^@ Belongs to the constitutive coactivator of PPAR-gamma family. http://togogenome.org/gene/9541:KIF4A ^@ http://purl.uniprot.org/uniprot/A0A2K5W5D4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:LOC101865419 ^@ http://purl.uniprot.org/uniprot/I7G804 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/9541:SIAH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXA6 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9541:RPL27 ^@ http://purl.uniprot.org/uniprot/Q4R8Z4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL27 family.|||Component of the large ribosomal subunit (By similarity). Interacts with RRP1B (By similarity). Component of the large ribosomal subunit. Interacts with RRP1B. Interacts with DHX33 (By similarity).|||Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity).|||Cytoplasm|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/9541:LOC102145248 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5X5 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/9541:CUL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VN06|||http://purl.uniprot.org/uniprot/G7PEQ4 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9541:RPL4 ^@ http://purl.uniprot.org/uniprot/Q4R5P9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Citrullinated by PADI4.|||Component of the large ribosomal subunit. May bind IPO9 with low affinity (By similarity). Interacts with RBM3 (By similarity).|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm http://togogenome.org/gene/9541:MMD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9541:NUDT7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UA83 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. PCD1 subfamily. http://togogenome.org/gene/9541:RXFP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAT2 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:SPSB1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y8G1|||http://purl.uniprot.org/uniprot/G7NTE0 ^@ Similarity ^@ Belongs to the SPSB family. http://togogenome.org/gene/9541:PIR ^@ http://purl.uniprot.org/uniprot/A0A2K5V2H4|||http://purl.uniprot.org/uniprot/G7Q298 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/9541:DCN ^@ http://purl.uniprot.org/uniprot/A0A8J8Y354|||http://purl.uniprot.org/uniprot/Q4R5D2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT.|||May affect the rate of fibrils formation.|||extracellular matrix http://togogenome.org/gene/9541:FUT8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 23 family.|||Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9541:HTR1E ^@ http://purl.uniprot.org/uniprot/A0A8J8YCP3|||http://purl.uniprot.org/uniprot/G7P3J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CNIH3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9541:RSPO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIC7 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9541:KCTD4 ^@ http://purl.uniprot.org/uniprot/I7GMV3 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:NUDT6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family.|||Cytoplasm|||May contribute to the regulation of cell proliferation.|||Mitochondrion|||Monomer and homodimer.|||Nucleus http://togogenome.org/gene/9541:GABRR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:ANAPC13 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQ33|||http://purl.uniprot.org/uniprot/G7NXY2 ^@ Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. http://togogenome.org/gene/9541:LOC102132001 ^@ http://purl.uniprot.org/uniprot/G7P2L9|||http://purl.uniprot.org/uniprot/G7P2N0|||http://purl.uniprot.org/uniprot/Q4R362 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.|||Belongs to the histone H4 family.|||Butyrylation of histones marks active promoters and competes with histone acetylation.|||Chromosome|||Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).|||Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.|||Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.|||Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.|||Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).|||Nucleus|||Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).|||Sumoylated, which is associated with transcriptional repression.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).|||Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. http://togogenome.org/gene/9541:COPS7B ^@ http://purl.uniprot.org/uniprot/A0A2K5WYD3|||http://purl.uniprot.org/uniprot/A0A2K5WYS7|||http://purl.uniprot.org/uniprot/A0A7N9CBY3|||http://purl.uniprot.org/uniprot/A0A7N9D9U6|||http://purl.uniprot.org/uniprot/A0A8J8XMR1|||http://purl.uniprot.org/uniprot/Q9BE14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:QPCT ^@ http://purl.uniprot.org/uniprot/A0A2K5WKT2 ^@ Similarity ^@ Belongs to the glutaminyl-peptide cyclotransferase family. http://togogenome.org/gene/9541:GSTO1 ^@ http://purl.uniprot.org/uniprot/C0SJM5 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/9541:LOC107129555 ^@ http://purl.uniprot.org/uniprot/A0A2K5UG77|||http://purl.uniprot.org/uniprot/G7PVW5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9541:TACC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWY8|||http://purl.uniprot.org/uniprot/A0A2K5UX50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||centrosome http://togogenome.org/gene/9541:TTR ^@ http://purl.uniprot.org/uniprot/G7PWK8|||http://purl.uniprot.org/uniprot/Q8HXW1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transthyretin family.|||Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4 (By similarity).|||Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.|||Secreted|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity).|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. http://togogenome.org/gene/9541:CSN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2A3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the kappa-casein family.|||Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.|||Secreted http://togogenome.org/gene/9541:SLC14A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urea transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102138227 ^@ http://purl.uniprot.org/uniprot/M9ZR32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lambda interferon family.|||Secreted http://togogenome.org/gene/9541:CELF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6I9|||http://purl.uniprot.org/uniprot/A0A2K5V782 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:TAF13 ^@ http://purl.uniprot.org/uniprot/I7G8Y8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ST6GALNAC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TS30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:ERC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDY2|||http://purl.uniprot.org/uniprot/A0A7N9D4D1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:SORCS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2U1 ^@ Similarity ^@ Belongs to the VPS10-related sortilin family. SORCS subfamily. http://togogenome.org/gene/9541:FAM210A ^@ http://purl.uniprot.org/uniprot/A0A7N9CLE0 ^@ Similarity ^@ Belongs to the FAM210 family. http://togogenome.org/gene/9541:ARCN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMK9|||http://purl.uniprot.org/uniprot/A0A2K5UMN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9541:CXCR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UV19 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Homomer. Forms heteromers with ACKR4.|||Membrane http://togogenome.org/gene/9541:NOL11 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNW6 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9541:RAB39A ^@ http://purl.uniprot.org/uniprot/A0A2K5VG96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:MED8 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:ZDHHC16 ^@ http://purl.uniprot.org/uniprot/G7PDP2|||http://purl.uniprot.org/uniprot/Q4R7E2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DHHC palmitoyltransferase family.|||Endoplasmic reticulum membrane|||Interacts with ABL1 (By similarity). Interacts with COPS5/JAB1 (By similarity).|||Membrane|||Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (By similarity). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (By similarity). May play a role in DNA damage response (By similarity). May be involved in apoptosis regulation (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity).|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:TEX28 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4U0 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9541:ACTN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIN2 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9541:DCP1B ^@ http://purl.uniprot.org/uniprot/A0A2K5ULS8 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/9541:TRMT1L ^@ http://purl.uniprot.org/uniprot/A0A2K5U3G4|||http://purl.uniprot.org/uniprot/Q4R6C7 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||May play a role in motor coordination and exploratory behavior. http://togogenome.org/gene/9541:SAMD8 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9541:SRRT ^@ http://purl.uniprot.org/uniprot/A0A2K5VDU6|||http://purl.uniprot.org/uniprot/G8F583 ^@ Similarity ^@ Belongs to the ARS2 family. http://togogenome.org/gene/9541:LOC102121157 ^@ http://purl.uniprot.org/uniprot/G7PQ24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TIMM17A ^@ http://purl.uniprot.org/uniprot/A0A8J8XC83|||http://purl.uniprot.org/uniprot/G7NWE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:EIF3H ^@ http://purl.uniprot.org/uniprot/A0A2K5UCA2|||http://purl.uniprot.org/uniprot/A0A8J8Y043 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit H family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9541:CORO1B ^@ http://purl.uniprot.org/uniprot/A0A2K5WK68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat coronin family.|||Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction.|||stress fiber http://togogenome.org/gene/9541:ENTPD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VH27 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9541:CD79B ^@ http://purl.uniprot.org/uniprot/A0A2K5WTG9|||http://purl.uniprot.org/uniprot/G8F5R6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:ETV5 ^@ http://purl.uniprot.org/uniprot/Q4R6H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:CNGA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8F1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TNP1 ^@ http://purl.uniprot.org/uniprot/G7PLE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear transition protein 1 family.|||Nucleus http://togogenome.org/gene/9541:LOC101867398 ^@ http://purl.uniprot.org/uniprot/A0A2K5W649|||http://purl.uniprot.org/uniprot/A0A7N9CGS2 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/9541:DMTF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWT6|||http://purl.uniprot.org/uniprot/A0A8J8YSC6|||http://purl.uniprot.org/uniprot/G7P1W2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CKAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2T3 ^@ Similarity ^@ Belongs to the CKAP2 family. http://togogenome.org/gene/9541:DNTT ^@ http://purl.uniprot.org/uniprot/A0A2K5WHH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Nucleus|||Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. http://togogenome.org/gene/9541:GNAT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XU61|||http://purl.uniprot.org/uniprot/G7NXT3 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9541:PEBP1 ^@ http://purl.uniprot.org/uniprot/P48737 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylethanolamine-binding protein family.|||Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity).|||Cytoplasm|||HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).|||Has a tendency to form dimers by disulfide cross-linking. Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade (By similarity). http://togogenome.org/gene/9541:ATP2B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VV70|||http://purl.uniprot.org/uniprot/A0A2K5VVJ3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||Membrane|||Presynaptic cell membrane|||Synaptic cell membrane|||synaptic vesicle membrane http://togogenome.org/gene/9541:PFDN6 ^@ http://purl.uniprot.org/uniprot/A0A8J8YMI4|||http://purl.uniprot.org/uniprot/G7P2S7 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/9541:DRD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4P9|||http://purl.uniprot.org/uniprot/G7NXM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.|||Membrane http://togogenome.org/gene/9541:B3GLCT ^@ http://purl.uniprot.org/uniprot/A0A2K5VWE5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GSDMC ^@ http://purl.uniprot.org/uniprot/A0A2K5TV39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:NTRK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VL93|||http://purl.uniprot.org/uniprot/A0A2K5VLB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/9541:LOC102144128 ^@ http://purl.uniprot.org/uniprot/A0A2K5URU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||cytoskeleton http://togogenome.org/gene/9541:CDH8 ^@ http://purl.uniprot.org/uniprot/G7Q1A7 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PEX5L ^@ http://purl.uniprot.org/uniprot/A0A2K5W6Y9|||http://purl.uniprot.org/uniprot/A0A2K5W703|||http://purl.uniprot.org/uniprot/A0A2K5W705|||http://purl.uniprot.org/uniprot/A0A2K5W720|||http://purl.uniprot.org/uniprot/A0A2K5W740|||http://purl.uniprot.org/uniprot/A0A8J8YAI2|||http://purl.uniprot.org/uniprot/G7NZ25|||http://purl.uniprot.org/uniprot/Q4R3L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal targeting signal receptor family.|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:THAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UT07|||http://purl.uniprot.org/uniprot/Q4R3Q6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THAP1 family.|||DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity).|||DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.|||Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter (By similarity).|||Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.|||PML body|||nucleoplasm http://togogenome.org/gene/9541:ITGA6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLQ4|||http://purl.uniprot.org/uniprot/A0A2K5WLW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9541:NUDT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4Q4|||http://purl.uniprot.org/uniprot/A0A2K5X4R4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family.|||Monomer.|||Nucleus http://togogenome.org/gene/9541:FGD6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL46|||http://purl.uniprot.org/uniprot/A0A2K5WL79 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:VAMP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9541:NTRK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UR97|||http://purl.uniprot.org/uniprot/A0A2K5URD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/9541:SLC31A1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZ70|||http://purl.uniprot.org/uniprot/G7PRM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Membrane http://togogenome.org/gene/9541:MSH4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WP15 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutS family. http://togogenome.org/gene/9541:MFAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WR60 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:SMPX ^@ http://purl.uniprot.org/uniprot/A0A8J8YPK5|||http://purl.uniprot.org/uniprot/G7Q2C8 ^@ Function|||Similarity ^@ Belongs to the SMPX family.|||Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. http://togogenome.org/gene/9541:LOC102123623 ^@ http://purl.uniprot.org/uniprot/A0A2K5URR0|||http://purl.uniprot.org/uniprot/A0A7N9CR01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat HIR1 family.|||Nucleus|||Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle. http://togogenome.org/gene/9541:RPL12 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBV0|||http://purl.uniprot.org/uniprot/G8F4M8 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL11 family.|||Binds directly to 26S ribosomal RNA. http://togogenome.org/gene/9541:GNG12 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9541:STRN ^@ http://purl.uniprot.org/uniprot/A0A2K5TXU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat striatin family.|||Membrane http://togogenome.org/gene/9541:SLC17A6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WED2|||http://purl.uniprot.org/uniprot/G8F4T4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PTGS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTA5 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the prostaglandin G/H synthase family.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LPAR1 ^@ http://purl.uniprot.org/uniprot/I7GN66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cell surface|||Endosome|||Membrane http://togogenome.org/gene/9541:SLC18A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Vesicular transporter family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9541:LOC102130423 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDR5|||http://purl.uniprot.org/uniprot/G8F456 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9541:ANXA6 ^@ http://purl.uniprot.org/uniprot/I7G3I4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.|||Melanosome http://togogenome.org/gene/9541:SH3RF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZW3|||http://purl.uniprot.org/uniprot/G7P8K4 ^@ Similarity ^@ Belongs to the SH3RF family. http://togogenome.org/gene/9541:DNAH11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VN65 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/9541:LOC102121958 ^@ http://purl.uniprot.org/uniprot/A0A7N9CAV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:YES1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8K8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9541:POLR3G ^@ http://purl.uniprot.org/uniprot/A0A7N9DIF0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9541:THPO ^@ http://purl.uniprot.org/uniprot/A0A2K5VLZ6|||http://purl.uniprot.org/uniprot/A0A2K5VM44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EPO/TPO family.|||Secreted http://togogenome.org/gene/9541:OTX1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YA87|||http://purl.uniprot.org/uniprot/G7PMB0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FCF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP23/FCF1 family. FCF1 subfamily.|||nucleolus http://togogenome.org/gene/9541:ASIC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDU9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CRELD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9I2 ^@ Caution|||Similarity ^@ Belongs to the CRELD family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:FEV ^@ http://purl.uniprot.org/uniprot/A0A2K5X8V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:LOC102140278 ^@ http://purl.uniprot.org/uniprot/A0A2K5UB81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SLC25A38 ^@ http://purl.uniprot.org/uniprot/A0A7N9DAR2|||http://purl.uniprot.org/uniprot/A0A7N9IC41|||http://purl.uniprot.org/uniprot/A0A8J8YS09|||http://purl.uniprot.org/uniprot/G7NYJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.|||Membrane|||Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.|||Mitochondrion inner membrane|||Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis. http://togogenome.org/gene/9541:LOC101867164 ^@ http://purl.uniprot.org/uniprot/G7Q174|||http://purl.uniprot.org/uniprot/Q4R930 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARL2BP family.|||Cytoplasm|||Interacts with GTP bound ARL2 and ARL3; the complex ARL2-ARL2BP as well as ARL2BP alone, binds to SLC25A4/ANT1. Interaction with ARL2 may be required for cilia basal body localization (By similarity). Interacts with STAT3; interaction is enhanced with ARL2. Found in a complex with ARL2BP, ARL2 and SLC25A6. Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with STAT2, STAT3 and STAT4.|||Mitochondrion intermembrane space|||Nucleus|||Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity).|||Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.|||centrosome|||cilium basal body|||spindle http://togogenome.org/gene/9541:PRDM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPR0|||http://purl.uniprot.org/uniprot/A0A2K5WPR3|||http://purl.uniprot.org/uniprot/A0A2K5WQ77 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.|||Nucleus|||Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. http://togogenome.org/gene/9541:PLCB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VG05|||http://purl.uniprot.org/uniprot/A0A2K5VG07 ^@ Function ^@ The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/9541:TSR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UI80 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9541:BCAT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCW8|||http://purl.uniprot.org/uniprot/A0A2K5WCY5|||http://purl.uniprot.org/uniprot/A0A2K5WD24 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9541:ORMDL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9541:LOC102136183 ^@ http://purl.uniprot.org/uniprot/A0A2K5URF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNF-like-inhibitor family.|||Secreted http://togogenome.org/gene/9541:CENPL ^@ http://purl.uniprot.org/uniprot/A0A2K5VU71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-L/IML3 family.|||Nucleus http://togogenome.org/gene/9541:GPATCH11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEM5 ^@ Similarity ^@ Belongs to the GPATCH11 family. http://togogenome.org/gene/9541:TRIM9 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3S7|||http://purl.uniprot.org/uniprot/A0A2K5V3V0|||http://purl.uniprot.org/uniprot/A0A7N9IEF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Nucleus|||cytoskeleton http://togogenome.org/gene/9541:SPCS2 ^@ http://purl.uniprot.org/uniprot/Q4R512 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SPCS2 family.|||Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).|||Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3. Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3. Within the complex, interacts with SEC11A or SEC11C and SPCS1. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:SLC39A8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYV6|||http://purl.uniprot.org/uniprot/A0A7N9IBY7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:MAP3K12 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIX3|||http://purl.uniprot.org/uniprot/A0A2K5VJ06 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||May be an activator of the JNK/SAPK pathway. http://togogenome.org/gene/9541:FABP7 ^@ http://purl.uniprot.org/uniprot/G7P392 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:ATP2A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5URR3|||http://purl.uniprot.org/uniprot/A0A2K5URW4|||http://purl.uniprot.org/uniprot/A0A7N9D608 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9541:C8A ^@ http://purl.uniprot.org/uniprot/A0A2K5U3L8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/9541:LOC102143756 ^@ http://purl.uniprot.org/uniprot/Q4R374 ^@ Function|||Subcellular Location Annotation ^@ Connects the two COX monomers into the physiological dimeric form.|||Mitochondrion intermembrane space http://togogenome.org/gene/9541:GPD1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YJY8|||http://purl.uniprot.org/uniprot/G7PIA0|||http://purl.uniprot.org/uniprot/I7GP10 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/9541:EPHA4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAZ2|||http://purl.uniprot.org/uniprot/G7PK59 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9541:EIF4H ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ19|||http://purl.uniprot.org/uniprot/I7GB85 ^@ Function|||Subcellular Location Annotation ^@ Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.|||perinuclear region http://togogenome.org/gene/9541:SCN7A ^@ http://purl.uniprot.org/uniprot/A0A2K5UFF4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9541:FARS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VG36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Mitochondrion matrix http://togogenome.org/gene/9541:NCF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U677 ^@ Similarity ^@ Belongs to the NCF2/NOXA1 family. http://togogenome.org/gene/9541:ZC3H14 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2F3|||http://purl.uniprot.org/uniprot/A0A2K5V2J6|||http://purl.uniprot.org/uniprot/Q4R6F6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZC3H14 family.|||Interacts with HOOK2. Interacts with ZFC3H1 in a RNase-sensitive manner.|||Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.|||Nucleus speckle http://togogenome.org/gene/9541:ESS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W123 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESS2 family.|||Nucleus http://togogenome.org/gene/9541:SMARCD3 ^@ http://purl.uniprot.org/uniprot/I7G324 ^@ Similarity ^@ Belongs to the SMARCD family. http://togogenome.org/gene/9541:RPA1 ^@ http://purl.uniprot.org/uniprot/Q4R388 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.|||Belongs to the replication factor A protein 1 family.|||Component of the heterotrimeric canonical replication protein A complex (RPA).|||Nucleus http://togogenome.org/gene/9541:RBM22 ^@ http://purl.uniprot.org/uniprot/Q4R4J1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLT11 family.|||Component of the pre-catalytic and catalytic spliceosome complexes. Component of the postcatalytic spliceosome P complex. Interacts with PDCD6; the interaction induces translocation of PDCD6 in the cytoplasm. Interacts with PPIL1 (By similarity).|||Cytoplasm|||Nucleus|||Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.|||The C-terminal RRM domain and the zinc finger motif are necessary for RNA-binding. http://togogenome.org/gene/9541:FIBCD1 ^@ http://purl.uniprot.org/uniprot/Q95LU3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components (By similarity).|||Homotetramer; disulfide-linked.|||Membrane http://togogenome.org/gene/9541:CNOT8 ^@ http://purl.uniprot.org/uniprot/A0A2K5W640|||http://purl.uniprot.org/uniprot/A0A8J8YH65|||http://purl.uniprot.org/uniprot/G7P6Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/9541:KCNH7 ^@ http://purl.uniprot.org/uniprot/A0A2K5URQ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GCDH ^@ http://purl.uniprot.org/uniprot/Q8HXX8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acyl-CoA dehydrogenase family.|||Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor (By similarity).|||Homotetramer.|||Mitochondrion matrix http://togogenome.org/gene/9541:MYOZ1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTD3 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9541:LOC102136791 ^@ http://purl.uniprot.org/uniprot/A0A2K5V173|||http://purl.uniprot.org/uniprot/A0A2K5V183|||http://purl.uniprot.org/uniprot/A0A2K5V186 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/9541:CSNK1G1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZG2|||http://purl.uniprot.org/uniprot/A0A2K5TZH0|||http://purl.uniprot.org/uniprot/A0A2K5TZI2|||http://purl.uniprot.org/uniprot/A0A2K5TZL5|||http://purl.uniprot.org/uniprot/A0A2K5TZN3|||http://purl.uniprot.org/uniprot/A0A7N9IBX7|||http://purl.uniprot.org/uniprot/A0A7N9IEM6|||http://purl.uniprot.org/uniprot/G8F3J7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/9541:MARVELD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9541:PRKD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZN0 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by DAG and phorbol esters.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:VPS13C ^@ http://purl.uniprot.org/uniprot/A0A2K5U9G5|||http://purl.uniprot.org/uniprot/A0A2K5U9J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS13 family.|||Lipid droplet http://togogenome.org/gene/9541:C14H11orf87 ^@ http://purl.uniprot.org/uniprot/Q9BGX9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NEXMIF ^@ http://purl.uniprot.org/uniprot/A0A2K5TUA9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CUTA ^@ http://purl.uniprot.org/uniprot/A0A2K5VJX9 ^@ Similarity|||Subunit ^@ Belongs to the CutA family.|||Homotrimer. http://togogenome.org/gene/9541:PAPOLB ^@ http://purl.uniprot.org/uniprot/Q4R386 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Binds 2 magnesium ions. Also active with manganese.|||Nucleus|||Polymerase that creates the 3'-poly(A) tail of mRNA's. http://togogenome.org/gene/9541:GPR171 ^@ http://purl.uniprot.org/uniprot/A0A2K5US76 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:CCNY ^@ http://purl.uniprot.org/uniprot/A0A2K5TS85|||http://purl.uniprot.org/uniprot/A0A7N9CXY4|||http://purl.uniprot.org/uniprot/Q95LK3 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/9541:CLTRN ^@ http://purl.uniprot.org/uniprot/A0A2K5WQK7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:UTP25 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP25 family.|||nucleolus http://togogenome.org/gene/9541:NOC2L ^@ http://purl.uniprot.org/uniprot/A0A2K5V4X6 ^@ Similarity ^@ Belongs to the NOC2 family. http://togogenome.org/gene/9541:CASP7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRR7 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9541:INTU ^@ http://purl.uniprot.org/uniprot/A0A2K5X7Z7|||http://purl.uniprot.org/uniprot/A0A2K5X815 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inturned family.|||Cell surface|||cilium basal body http://togogenome.org/gene/9541:SYNPR ^@ http://purl.uniprot.org/uniprot/A0A2K5X4L0|||http://purl.uniprot.org/uniprot/A0A2K5X4L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/9541:CAPN12 ^@ http://purl.uniprot.org/uniprot/Q4R721 ^@ Caution|||Similarity ^@ Belongs to the peptidase C2 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:RPL15 ^@ http://purl.uniprot.org/uniprot/Q4R5B2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL15 family.|||Component of the large ribosomal subunit. Interacts with IFIT1 (via TPR repeats 1-4).|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm http://togogenome.org/gene/9541:LDAF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTW3|||http://purl.uniprot.org/uniprot/G7Q0N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LDAF1 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Membrane http://togogenome.org/gene/9541:SLITRK2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YCU9|||http://purl.uniprot.org/uniprot/G7Q1V4 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9541:TRUB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAI1 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/9541:CAV3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ78|||http://purl.uniprot.org/uniprot/G7NYV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola|||sarcolemma http://togogenome.org/gene/9541:ARMC8 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3B8|||http://purl.uniprot.org/uniprot/A0A2K5W3E8|||http://purl.uniprot.org/uniprot/A0A2K5W3L1|||http://purl.uniprot.org/uniprot/Q4R4K9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:RTRAF ^@ http://purl.uniprot.org/uniprot/A0A8J8XBC5|||http://purl.uniprot.org/uniprot/G7PA92 ^@ Similarity ^@ Belongs to the RTRAF family. http://togogenome.org/gene/9541:MMP11 ^@ http://purl.uniprot.org/uniprot/A0A2K5U682 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9541:SSRP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XSE2|||http://purl.uniprot.org/uniprot/G7PQ43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSRP1 family.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Nucleus http://togogenome.org/gene/9541:YIPF4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XRH1|||http://purl.uniprot.org/uniprot/G7PLZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/9541:LOC102143204 ^@ http://purl.uniprot.org/uniprot/A0A8J8YHA3|||http://purl.uniprot.org/uniprot/G7PET2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ITGB5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Membrane http://togogenome.org/gene/9541:MAB21L3 ^@ http://purl.uniprot.org/uniprot/G7NX46 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9541:CDC42EP3 ^@ http://purl.uniprot.org/uniprot/I7GEW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9541:ABCC2 ^@ http://purl.uniprot.org/uniprot/A5GZW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:NRG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYN7|||http://purl.uniprot.org/uniprot/A0A2K5TYQ0|||http://purl.uniprot.org/uniprot/A0A2K5TYQ1|||http://purl.uniprot.org/uniprot/A0A2K5TYQ7|||http://purl.uniprot.org/uniprot/A0A2K5TYT4|||http://purl.uniprot.org/uniprot/A0A7N9CGF1|||http://purl.uniprot.org/uniprot/A0A7N9CJ89|||http://purl.uniprot.org/uniprot/A0A7N9DEP1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neuregulin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/9541:PKIG ^@ http://purl.uniprot.org/uniprot/A0A8J8XTY9|||http://purl.uniprot.org/uniprot/G7PGB4 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9541:NRXN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNE0|||http://purl.uniprot.org/uniprot/A0A2K5WNE8|||http://purl.uniprot.org/uniprot/A0A2K5WNF7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:APOBEC3A ^@ http://purl.uniprot.org/uniprot/A0A0K0MJ52 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:LOC102122713 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJX2|||http://purl.uniprot.org/uniprot/G7PUV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HOP2 family.|||Nucleus http://togogenome.org/gene/9541:DOCK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQR8 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9541:TIMM10 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0Z3 ^@ Function ^@ Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. http://togogenome.org/gene/9541:SCARB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X348|||http://purl.uniprot.org/uniprot/G7P552 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9541:KPNA5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMW1|||http://purl.uniprot.org/uniprot/A0A2K5TMX7|||http://purl.uniprot.org/uniprot/A0A7N9CCA9 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9541:LOC102134263 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDT1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL28 family. http://togogenome.org/gene/9541:SLC9B2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTG6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:FAM214B ^@ http://purl.uniprot.org/uniprot/A0A2K5VGE7|||http://purl.uniprot.org/uniprot/Q4R676 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATOS family.|||Belongs to the FAM214 family.|||Nucleus|||The protein contains a transactivation domain (TAD) which may be required for transcriptional activation of a subset of target genes.|||Transcription regulator that may syncronize transcriptional and translational programs. http://togogenome.org/gene/9541:TRAM1L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMW3|||http://purl.uniprot.org/uniprot/G7P657 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/9541:XKR8 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9541:PDIA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKB0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen|||Part of a large chaperone multiprotein complex. http://togogenome.org/gene/9541:USP44 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ16 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9541:FIP1L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1Z4|||http://purl.uniprot.org/uniprot/A0A2K5W200|||http://purl.uniprot.org/uniprot/A0A2K5W202|||http://purl.uniprot.org/uniprot/A0A2K5W211|||http://purl.uniprot.org/uniprot/A0A2K5W248 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus http://togogenome.org/gene/9541:SEC23A ^@ http://purl.uniprot.org/uniprot/A0A2K5UC61|||http://purl.uniprot.org/uniprot/A0A8J8Y3C6|||http://purl.uniprot.org/uniprot/G7PA49 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9541:VSX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIW0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:KCTD17 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7C5|||http://purl.uniprot.org/uniprot/A0A2K5W7E2|||http://purl.uniprot.org/uniprot/A0A2K5W7I0 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:SLC35E2B ^@ http://purl.uniprot.org/uniprot/A0A2K5TL70|||http://purl.uniprot.org/uniprot/G8F5J0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TAGLN3 ^@ http://purl.uniprot.org/uniprot/G8F2A6|||http://purl.uniprot.org/uniprot/Q4R5J4 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9541:LOC102117077 ^@ http://purl.uniprot.org/uniprot/Q8MHW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uricase family.|||Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.|||Peroxisome http://togogenome.org/gene/9541:TCF7L2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VE57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/9541:AURKA ^@ http://purl.uniprot.org/uniprot/A0A2K5TW98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||centrosome http://togogenome.org/gene/9541:LAMB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQY0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9541:GPM6A ^@ http://purl.uniprot.org/uniprot/A0A2K5UT87|||http://purl.uniprot.org/uniprot/A0A2K5UTC4|||http://purl.uniprot.org/uniprot/A0A8J8XLU9|||http://purl.uniprot.org/uniprot/I7GLI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9541:CCNL2 ^@ http://purl.uniprot.org/uniprot/I7GHV1 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9541:CCN5 ^@ http://purl.uniprot.org/uniprot/A0A2K5W299 ^@ Similarity ^@ Belongs to the CCN family. http://togogenome.org/gene/9541:CCDC188 ^@ http://purl.uniprot.org/uniprot/A0A2K5X355|||http://purl.uniprot.org/uniprot/A0A7N9CRF3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:MAPK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXY8 ^@ Subcellular Location Annotation ^@ caveola http://togogenome.org/gene/9541:LRRC14 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAS4|||http://purl.uniprot.org/uniprot/I7GI07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRAME family. LRRC14 subfamily.|||Cytoplasm http://togogenome.org/gene/9541:PBX4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/9541:CCR3 ^@ http://purl.uniprot.org/uniprot/Q8WMR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TGM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXI8 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9541:PICALM ^@ http://purl.uniprot.org/uniprot/A0A2K5WE69|||http://purl.uniprot.org/uniprot/A0A2K5WEB3|||http://purl.uniprot.org/uniprot/A0A2K5WEK1|||http://purl.uniprot.org/uniprot/A0A2K5WES9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PICALM/SNAP91 family.|||Membrane http://togogenome.org/gene/9541:LOC102122063 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7S4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIII family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:RPF1 ^@ http://purl.uniprot.org/uniprot/I7G9K8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9541:TRIAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDY0 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/9541:TRIM59 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQE4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TAX1BP3 ^@ http://purl.uniprot.org/uniprot/I7GLD5 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.|||Nucleus http://togogenome.org/gene/9541:RAB29 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXI9|||http://purl.uniprot.org/uniprot/G7NVC5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9541:RFTN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGS9|||http://purl.uniprot.org/uniprot/G7NY19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102144671 ^@ http://purl.uniprot.org/uniprot/G7PKU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS2 family.|||Cytoplasm http://togogenome.org/gene/9541:GPRIN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBE2 ^@ Function ^@ May be involved in neurite outgrowth. http://togogenome.org/gene/9541:CD3E ^@ http://purl.uniprot.org/uniprot/A0A2K5TR65|||http://purl.uniprot.org/uniprot/A0A2K5TR92|||http://purl.uniprot.org/uniprot/Q95LI5 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Membrane|||Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.|||Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.|||The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. Interacts with CD6. Interacts with NCK1. Interacts with NUMB; this interaction is important for TCR-CD3 internalization and subsequent degradation. http://togogenome.org/gene/9541:RNF170 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWH0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:RAB3A ^@ http://purl.uniprot.org/uniprot/G8F4H9|||http://purl.uniprot.org/uniprot/Q4R4R9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Interacts with RIMS1 and RIMS2 (By similarity). Interacts with Rabphilin-3A/RPH3A and Rab effector Noc2/RPH3AL (By similarity). Interacts with SYTL4 (By similarity). Interacts with RAB3IP (By similarity). Interacts with SGSM1 and SGSM3 (By similarity). Interacts with SYT1 (By similarity). Interacts with MYH9; this interaction is essential for lysosome exocytosis and plasma membrane repair (By similarity). Interacts with STXBP1; this interaction promotes RAB3A dissociation from the vesicle membrane (By similarity). Interacts with GDI1, GDI2, CHM and CHML; phosphorylation at Thr-86 disrupts these interactions (By similarity). Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction (By similarity).|||Lysosome|||Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.|||Postsynapse|||Presynapse|||Protein transport. Probably involved in vesicular traffic.|||Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (By similarity). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (By similarity). Also plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity).|||axon|||cytosol|||secretory vesicle http://togogenome.org/gene/9541:ATIC ^@ http://purl.uniprot.org/uniprot/A0A2K5VNR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PurH family.|||Cytoplasm http://togogenome.org/gene/9541:CTNNA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WE01|||http://purl.uniprot.org/uniprot/A0A8J8XE84|||http://purl.uniprot.org/uniprot/G7PML1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||Nucleus|||adherens junction|||axon|||cytoskeleton http://togogenome.org/gene/9541:ZNF706 ^@ http://purl.uniprot.org/uniprot/A0A2K5VS81 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:THRB ^@ http://purl.uniprot.org/uniprot/A0A2K5UEL1|||http://purl.uniprot.org/uniprot/A0A2K5V0F5|||http://purl.uniprot.org/uniprot/A0A8J8XIM7|||http://purl.uniprot.org/uniprot/I7GID1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9541:NKAIN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:HNRNPF ^@ http://purl.uniprot.org/uniprot/A0A8J8YQZ5|||http://purl.uniprot.org/uniprot/G7PER4|||http://purl.uniprot.org/uniprot/Q60HC3 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity).|||Identified in the spliceosome C complex. Interacts with AGO1, AGO2, TBP and TXNL4/DIM1 (By similarity).|||Sumoylated.|||The N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA.|||nucleoplasm http://togogenome.org/gene/9541:CMTM6 ^@ http://purl.uniprot.org/uniprot/Q4R3R0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:EHD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6F2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane|||Recycling endosome membrane|||cilium membrane http://togogenome.org/gene/9541:LOC102135021 ^@ http://purl.uniprot.org/uniprot/A0A2K5VN21 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:PKLR ^@ http://purl.uniprot.org/uniprot/A0A2K5WL75 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/9541:ARSL ^@ http://purl.uniprot.org/uniprot/A0A2K5WPD0|||http://purl.uniprot.org/uniprot/A0A2K5WPF2|||http://purl.uniprot.org/uniprot/Q60HH5 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Exhibits arylsulfatase activity towards the artificial substrate 4-methylumbelliferyl sulfate (By similarity). May be essential for the correct composition of cartilage and bone matrix during development (By similarity). Has no activity toward steroid sulfates (By similarity).|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9541:REXO4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0G0 ^@ Similarity ^@ Belongs to the REXO4 family. http://togogenome.org/gene/9541:CCNA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBK9|||http://purl.uniprot.org/uniprot/Q4R337 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily. http://togogenome.org/gene/9541:TRIM22 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Nucleus http://togogenome.org/gene/9541:YOD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQS7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin. http://togogenome.org/gene/9541:HTR3A ^@ http://purl.uniprot.org/uniprot/A0A2K5VME5|||http://purl.uniprot.org/uniprot/A0A2K5VML6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/9541:ACSS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7L5|||http://purl.uniprot.org/uniprot/A0A2K5W7S0 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9541:BEST3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDZ3|||http://purl.uniprot.org/uniprot/A0A2K5WE00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bestrophin family.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9541:ZUP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8Z7|||http://purl.uniprot.org/uniprot/Q4R4A2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C78 family. ZUFSP subfamily.|||C2H2-type zinc finger 4 is a ubiquitin-binding zinc finger (UBZ) and required for polyubiquitin binding, possibly binding the proximal ubiqutin, and for catalytic activity. C2H2-type zinc fingers 1-3 are required for localization to sites of DNA damage.|||Cytoplasm|||Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress.|||Interacts with RPA1 and RPA2.|||Nucleus|||The motif interacting with ubiquitin (MIU) and ZUFSP ubiquitin-binding domain (zUBD, also called ZUFSP helical arm ZHA) are responsible for binding the distal (outgoing) ubiquitin units S1 and S2 respectively. http://togogenome.org/gene/9541:PRPF38A ^@ http://purl.uniprot.org/uniprot/Q8HXH6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRP38 family.|||Component of the spliceosome B complex. Interacts (via N-terminal interaction domain) with ZMAT2 and MFAP1.|||Involved in pre-mRNA splicing as a component of the spliceosome.|||Nucleus http://togogenome.org/gene/9541:GNA11 ^@ http://purl.uniprot.org/uniprot/A0A2K5WV53 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/9541:ALG3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.|||Belongs to the glycosyltransferase 58 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:PAPOLA ^@ http://purl.uniprot.org/uniprot/A0A2K5TXF8|||http://purl.uniprot.org/uniprot/A0A2K5TXG9|||http://purl.uniprot.org/uniprot/A0A2K5TXH2|||http://purl.uniprot.org/uniprot/A0A2K5TXL7|||http://purl.uniprot.org/uniprot/A0A2K5TXP6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Binds 2 magnesium ions. Also active with manganese.|||Nucleus|||Polymerase that creates the 3'-poly(A) tail of mRNA's. http://togogenome.org/gene/9541:NXPH3 ^@ http://purl.uniprot.org/uniprot/G7PU90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9541:GLP2R ^@ http://purl.uniprot.org/uniprot/A0A2K5WMI4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PTK6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCJ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9541:ZACN ^@ http://purl.uniprot.org/uniprot/A0A2K5TZW0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:EXOSC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5R2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:TAGLN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZ75 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9541:HOXC5 ^@ http://purl.uniprot.org/uniprot/A0A7N9CSP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9541:PTER ^@ http://purl.uniprot.org/uniprot/A0A2K5WQE1 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.|||Binds 2 divalent metal cations per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:DPH3 ^@ http://purl.uniprot.org/uniprot/G7NY17|||http://purl.uniprot.org/uniprot/Q4R312 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPH3 family.|||Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase (By similarity). Interacts with SERGEF (By similarity).|||Cytoplasm|||Nucleus|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).|||The DPH-type metal-binding (MB) domain can also bind zinc. However, iron is the physiological binding partner as zinc binding impairs the protein electron donor function. http://togogenome.org/gene/9541:DPH6 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4G7|||http://purl.uniprot.org/uniprot/G7PAQ2 ^@ Function|||Similarity ^@ Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.|||Belongs to the Diphthine--ammonia ligase family. http://togogenome.org/gene/9541:LOC102127563 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN61 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TTC30A ^@ http://purl.uniprot.org/uniprot/A0A2K5UG69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TTC30/dfy-1/fleer family.|||Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.|||cilium http://togogenome.org/gene/9541:SMC1A ^@ http://purl.uniprot.org/uniprot/A0A8J8XR42|||http://purl.uniprot.org/uniprot/G7Q2S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9541:PCYT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X869 ^@ Similarity ^@ Belongs to the cytidylyltransferase family. http://togogenome.org/gene/9541:CAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2A6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CAP family.|||Cell membrane|||Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.|||Homodimer. Binds actin monomers.|||Membrane http://togogenome.org/gene/9541:LOC102123177 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3J4|||http://purl.uniprot.org/uniprot/A0A2K5V3K6 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/9541:CR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5URA2|||http://purl.uniprot.org/uniprot/A0A2K5URG6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:P3H2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPJ7 ^@ Similarity ^@ Belongs to the leprecan family. http://togogenome.org/gene/9541:OS9 ^@ http://purl.uniprot.org/uniprot/A0A2K5TS93 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum lumen http://togogenome.org/gene/9541:PSMD13 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1C5|||http://purl.uniprot.org/uniprot/I7GJN4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S11 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9541:GRK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZT8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9541:KCNA2 ^@ http://purl.uniprot.org/uniprot/G7NW44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.|||Cell membrane|||Membrane|||Presynaptic cell membrane|||Synaptic cell membrane|||lamellipodium membrane|||paranodal septate junction|||synaptosome http://togogenome.org/gene/9541:LOC102138546 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQA3|||http://purl.uniprot.org/uniprot/G7NTQ1 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9541:ROGDI ^@ http://purl.uniprot.org/uniprot/A0A2K5WBA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rogdi family.|||Perikaryon|||Presynapse|||synaptic vesicle http://togogenome.org/gene/9541:TRIT1 ^@ http://purl.uniprot.org/uniprot/I7G8M2 ^@ Function|||Similarity ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37. http://togogenome.org/gene/9541:RHBDL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5G2|||http://purl.uniprot.org/uniprot/A0A2K5U5J8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.|||Membrane http://togogenome.org/gene/9541:GLE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4I3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GLE1 family.|||Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9541:CD200 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQR9|||http://purl.uniprot.org/uniprot/A0A7N9CJ77 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:SEMA3G ^@ http://purl.uniprot.org/uniprot/A0A2K5UWL2 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:BLM ^@ http://purl.uniprot.org/uniprot/A0A2K5VCZ7 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/9541:IDI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKE6 ^@ Function|||Similarity ^@ Belongs to the IPP isomerase type 1 family.|||Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/9541:HSF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4N2|||http://purl.uniprot.org/uniprot/A0A2K5V4N8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9541:NOL12 ^@ http://purl.uniprot.org/uniprot/A0A2K5UD50 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP17 family.|||Interacts with KIAA1191.|||nucleolus http://togogenome.org/gene/9541:SIDT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6U2|||http://purl.uniprot.org/uniprot/G7PP16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SID1 family.|||Membrane http://togogenome.org/gene/9541:PGM5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRN8 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9541:HSD17B1 ^@ http://purl.uniprot.org/uniprot/Q4JK77 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:LOC102146235 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the argonaute family.|||P-body http://togogenome.org/gene/9541:ABLIM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V972 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:TPM3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHD1|||http://purl.uniprot.org/uniprot/A0A2K5WHI5|||http://purl.uniprot.org/uniprot/A0A2K5WHI9|||http://purl.uniprot.org/uniprot/A0A2K5WHL3|||http://purl.uniprot.org/uniprot/A0A2K5WHN5|||http://purl.uniprot.org/uniprot/I7GED0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9541:MYH15 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4H2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:CDK9 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDZ1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:PTPRK ^@ http://purl.uniprot.org/uniprot/A0A2K5WV32|||http://purl.uniprot.org/uniprot/A0A2K5WVQ2|||http://purl.uniprot.org/uniprot/A0A7N9CLR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.|||Membrane http://togogenome.org/gene/9541:CORO2A ^@ http://purl.uniprot.org/uniprot/A0A2K5UKF1 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9541:GSR ^@ http://purl.uniprot.org/uniprot/A0A2K5W9Z6 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/9541:LOC102131283 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTG9 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/9541:LOC102127148 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBW1 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9541:CHST11 ^@ http://purl.uniprot.org/uniprot/A0A8J8YIA6|||http://purl.uniprot.org/uniprot/G7PJD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:SEPTIN10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSH9|||http://purl.uniprot.org/uniprot/A0A2K5VSK9|||http://purl.uniprot.org/uniprot/A0A2K5VSL0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9541:LOC102124217 ^@ http://purl.uniprot.org/uniprot/A0A7N9DA66 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102129705 ^@ http://purl.uniprot.org/uniprot/A0A2K5WM70 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/9541:CD163 ^@ http://purl.uniprot.org/uniprot/A0A2K5US09 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:RAB27A ^@ http://purl.uniprot.org/uniprot/A0A8J8XYX3|||http://purl.uniprot.org/uniprot/G7PBI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9541:HCFC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKP6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MDGA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYH6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102124448 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWB2|||http://purl.uniprot.org/uniprot/A0A2K5W923 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9541:APPL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAG7|||http://purl.uniprot.org/uniprot/A0A2K5UAJ3 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Nucleus|||phagosome|||ruffle http://togogenome.org/gene/9541:PCID2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WE74 ^@ Similarity ^@ Belongs to the CSN12 family. http://togogenome.org/gene/9541:SLC9A3R1 ^@ http://purl.uniprot.org/uniprot/Q4R6G4 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Cytoplasm|||Endomembrane system|||Homodimer, and heterodimer with SLC9A3R2. Binds the N-termini of EZR, RDX and MSN. Binds the C-termini of PDGFRA, PDGFRB, ADRB2, NOS2 and CFTR. Binds ARHGAP17, EPI64, RACK1, OPRK1, GNAQ, CTNNB1 and PLCB3. Binds PDZK1 (By similarity). Interacts with CLCN3. Binds the C-terminus of PAG1. In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation. Forms a complex with CFTR and SLC4A7. Forms a complex with SLC4A7 and ATP6V1B1. Interacts with TRPC4 (via the PDZ-binding domain). Directly interacts with HTR4 (By similarity). Interacts (via the PDZ 1 domain) with PODXL (via the C-terminal PDZ-binding motif DTHL); interaction is not detected in glomerular epithelium cells. Interacts (via the PDZ 1 domain) with PODXL (via the C-terminal PDZ-binding motif DTHL); the interaction take place early in the secretory pathway and is necessary for its apical membrane sorting (By similarity). Interacts with SLC26A3 (By similarity). Interacts with MCC. Interacts with SLC34A1. Interacts (via the PDZ domains) with SLC26A6 isoform 4 and isoform 5 (By similarity). Interacts (via PDZ domains) with ACE2 (via PDZ-binding motif); the interaction may enhance ACE2 membrane residence (By similarity).|||Phosphorylated on serine residues.|||Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules (By similarity).|||filopodium|||microvillus|||ruffle http://togogenome.org/gene/9541:FAM131B ^@ http://purl.uniprot.org/uniprot/G7P1I0 ^@ Similarity ^@ Belongs to the FAM131 family. http://togogenome.org/gene/9541:PDE9A ^@ http://purl.uniprot.org/uniprot/A0A2K5W5U9|||http://purl.uniprot.org/uniprot/A0A2K5W5Y4 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:P4HA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5USE8|||http://purl.uniprot.org/uniprot/A0A2K5USF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9541:RASGRP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VT05 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9541:FUZ ^@ http://purl.uniprot.org/uniprot/A0A2K5W9A6|||http://purl.uniprot.org/uniprot/G7PY82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fuzzy family.|||cytoskeleton http://togogenome.org/gene/9541:LOC102127185 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYJ1|||http://purl.uniprot.org/uniprot/A0A2K5VYL2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b560 family.|||Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). http://togogenome.org/gene/9541:KIF2C ^@ http://purl.uniprot.org/uniprot/A0A2K5VIH2|||http://purl.uniprot.org/uniprot/Q95LP1 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.|||In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment.|||Interacts with CENPH. Interacts with MTUS2/TIP150; the interaction is direct. Interacts with MAPRE1; the interaction is direct, regulated by phosphorylation and is probably required for targeting to growing microtubule plus ends. Interacts with KIF18B at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. Phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.|||Nucleus|||Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity.|||The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.|||Ubiquitinated.|||centromere|||cytoskeleton|||kinetochore http://togogenome.org/gene/9541:DNAI7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZR8|||http://purl.uniprot.org/uniprot/A0A2K5UZS8|||http://purl.uniprot.org/uniprot/A0A2K5UZV7|||http://purl.uniprot.org/uniprot/A0A7N9CMR9 ^@ Similarity ^@ Belongs to the DNAI7 family. http://togogenome.org/gene/9541:LOC102137182 ^@ http://purl.uniprot.org/uniprot/I7GEP1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.|||Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. http://togogenome.org/gene/9541:PLAU ^@ http://purl.uniprot.org/uniprot/A0A2K5WND1 ^@ Caution|||Function ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. http://togogenome.org/gene/9541:IKBKB ^@ http://purl.uniprot.org/uniprot/A0A2K5WXY7|||http://purl.uniprot.org/uniprot/A0A2K5WXZ0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:ZBED9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VS64 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:B3GALNT1 ^@ http://purl.uniprot.org/uniprot/A0A7N9ICJ4|||http://purl.uniprot.org/uniprot/A0A8J8XWK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:CBLIF ^@ http://purl.uniprot.org/uniprot/A0A2K5WX57|||http://purl.uniprot.org/uniprot/G7PQ13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9541:KYAT3 ^@ http://purl.uniprot.org/uniprot/I7G3V9 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/9541:LOC102124073 ^@ http://purl.uniprot.org/uniprot/A0A2K5X506 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9541:AIDA ^@ http://purl.uniprot.org/uniprot/A0A2K5TYC5|||http://purl.uniprot.org/uniprot/A0A7N9CRW4 ^@ Similarity ^@ Belongs to the AIDA family. http://togogenome.org/gene/9541:KCNK17 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9541:VRK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBQ9|||http://purl.uniprot.org/uniprot/G7PBF9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:MYADM ^@ http://purl.uniprot.org/uniprot/A0A2K5UNG8|||http://purl.uniprot.org/uniprot/G7PYR1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ETFA ^@ http://purl.uniprot.org/uniprot/A0A2K5UHW7|||http://purl.uniprot.org/uniprot/Q8HXY0 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer.|||Domain I shares an identical polypeptide fold with the beta subunit ETFB though there is no sequence similarity.|||Heterodimer composed of ETFA and ETFB. Identified in a complex that contains ETFA, ETFB and ETFRF1. Interaction with ETFRF1 promotes dissociation of the bound FAD and loss of electron transfer activity (By similarity). Interacts with TASOR (By similarity).|||Heterodimer of an alpha and a beta subunit.|||Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/9541:ARMC9 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4C7|||http://purl.uniprot.org/uniprot/A0A2K5W4F0|||http://purl.uniprot.org/uniprot/A0A2K5W4F5 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with TOGARAM1, CCDC66, CEP104, CSPP1 and CEP290.|||centriole|||cilium|||cilium basal body http://togogenome.org/gene/9541:LHX9 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRT2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102121747 ^@ http://purl.uniprot.org/uniprot/G7PHX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ELF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1K0|||http://purl.uniprot.org/uniprot/A0A2K5W1K2|||http://purl.uniprot.org/uniprot/A0A2K5W1M3|||http://purl.uniprot.org/uniprot/A0A7N9IDC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:PPP1R1B ^@ http://purl.uniprot.org/uniprot/A0A2K5VVV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein phosphatase inhibitor 1 family.|||Cytoplasm|||Inhibitor of protein-phosphatase 1. http://togogenome.org/gene/9541:PNO1 ^@ http://purl.uniprot.org/uniprot/I7GPI7 ^@ Similarity ^@ Belongs to the PNO1 family. http://togogenome.org/gene/9541:DNAH6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WM92 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/9541:GALK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7J7|||http://purl.uniprot.org/uniprot/A0A2K5X7L4|||http://purl.uniprot.org/uniprot/A0A2K5X7N2|||http://purl.uniprot.org/uniprot/A0A2K5X803|||http://purl.uniprot.org/uniprot/A0A7N9CR67|||http://purl.uniprot.org/uniprot/G7PBA6 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/9541:B4GALNT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WET1|||http://purl.uniprot.org/uniprot/G7PIW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:TERF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKE1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.|||Homodimer.|||Nucleus|||telomere http://togogenome.org/gene/9541:SLC8A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1P5|||http://purl.uniprot.org/uniprot/A0A2K5U1S3|||http://purl.uniprot.org/uniprot/A0A2K5U1T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:GPR108 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNF3|||http://purl.uniprot.org/uniprot/A0A2K5WNL4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SYNGR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/9541:STEAP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W645 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9541:CKAP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOG/XMAP215 family.|||kinetochore http://togogenome.org/gene/9541:CDKN1C ^@ http://purl.uniprot.org/uniprot/A0A0D5XPB6|||http://purl.uniprot.org/uniprot/A0A2K5TS78 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/9541:EDEM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEL9|||http://purl.uniprot.org/uniprot/I7GDC0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9541:FGF9 ^@ http://purl.uniprot.org/uniprot/A0A8J8XCT6|||http://purl.uniprot.org/uniprot/G7PVU6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heparin-binding growth factors family.|||Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.|||Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.|||Secreted http://togogenome.org/gene/9541:IRAK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX67 ^@ Function|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.|||Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. http://togogenome.org/gene/9541:ARHGEF28 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKY4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:PMM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXA7|||http://purl.uniprot.org/uniprot/A0A7N9D5M6|||http://purl.uniprot.org/uniprot/G7Q0G7|||http://purl.uniprot.org/uniprot/Q60HD6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9541:GSTM5 ^@ http://purl.uniprot.org/uniprot/Q4R5L3 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Mu family.|||Homodimer. http://togogenome.org/gene/9541:PRKAG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZ55|||http://purl.uniprot.org/uniprot/I7GNX4|||http://purl.uniprot.org/uniprot/Q4R5P4 ^@ Similarity|||Subunit ^@ AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.|||Belongs to the 5'-AMP-activated protein kinase gamma subunit family. http://togogenome.org/gene/9541:PRTFDC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY00|||http://purl.uniprot.org/uniprot/A0A2K5WYI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/9541:SAG ^@ http://purl.uniprot.org/uniprot/A0A2K5VU20 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9541:IQUB ^@ http://purl.uniprot.org/uniprot/Q4R6T7 ^@ Function|||Subunit ^@ Interacts with ZMYND10.|||May play roles in cilia formation and/or maintenance. http://togogenome.org/gene/9541:RPS20 ^@ http://purl.uniprot.org/uniprot/G7Q2E4|||http://purl.uniprot.org/uniprot/Q4R5D0 ^@ PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Component of the 40S small ribosomal subunit.|||Cytoplasm|||Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide.|||Ufmylated by UFL1. http://togogenome.org/gene/9541:OTC ^@ http://purl.uniprot.org/uniprot/A0A2K5U1P3 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily.|||Homotrimer. http://togogenome.org/gene/9541:CREBL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WER1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Nucleus http://togogenome.org/gene/9541:ATCAY ^@ http://purl.uniprot.org/uniprot/Q9GKT0 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cleaved by CASP3 and CASP7. The potential C-terminal product released by CASP3 cleavage may inhibit the ERK signaling pathway through MAP2K2 (By similarity).|||Cytoplasm|||Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites (By similarity).|||Interacts with KLC1; may link mitochondria to KLC1 and regulate mitochondria localization into neuron projections. Interacts with GLS; the interaction is direct and may control GLS localization, negatively regulating its activity. Interacts with PIN1 (via WW domain); upon NGF stimulation. The interaction with PIN1 and GLS is competitive.|||May be ubiquitinated by STUB1.|||Mitochondrion|||Presynapse|||The CRAL-TRIO domain is known to bind small hydrophobic molecules.|||axon|||dendrite|||growth cone http://togogenome.org/gene/9541:CPSF3 ^@ http://purl.uniprot.org/uniprot/Q4R7A0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TMEM161A ^@ http://purl.uniprot.org/uniprot/A0A2K5VGM3|||http://purl.uniprot.org/uniprot/A0A2K5VGN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM161 family.|||Membrane http://togogenome.org/gene/9541:RAG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMJ1|||http://purl.uniprot.org/uniprot/G7PQD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAG2 family.|||Nucleus http://togogenome.org/gene/9541:OASL ^@ http://purl.uniprot.org/uniprot/A0A2K5VET5 ^@ Similarity ^@ Belongs to the 2-5A synthase family. http://togogenome.org/gene/9541:ITPR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W261|||http://purl.uniprot.org/uniprot/A0A2K5W2H1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the InsP3 receptor family.|||Endoplasmic reticulum membrane|||Homotetramer.|||Membrane|||Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.|||The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. http://togogenome.org/gene/9541:CD244 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3W5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102128952 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9541:AGTR2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XX36|||http://purl.uniprot.org/uniprot/G7Q3I3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MTUS1.|||Membrane http://togogenome.org/gene/9541:APTX ^@ http://purl.uniprot.org/uniprot/Q9BGQ0 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity).|||Interacts with single-strand break repair proteins XRCC1, XRCC4, ADPRT/PARP1 and p53/TP53. Interacts with NCL. Interacts (via FHA-like domain) with MDC1 (phosphorylated).|||The C2H2-type zinc finger mediates DNA-binding.|||The FHA-like domain mediates interaction with NCL; XRCC1 and XRCC4.|||The HIT domain is required for enzymatic activity.|||The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9541:PKIB ^@ http://purl.uniprot.org/uniprot/I7GE53 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9541:SOX6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKQ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NPC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/9541:DRC3 ^@ http://purl.uniprot.org/uniprot/Q4R6X9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DRC3 family.|||Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.|||Component of the nexin-dynein regulatory complex (N-DRC). Interacts with TCTE1/DRC5 (By similarity). Interacts with DRC7 (By similarity).|||cilium|||cilium axoneme|||flagellum|||flagellum axoneme http://togogenome.org/gene/9541:ADGRE5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8T8|||http://purl.uniprot.org/uniprot/A0A2K5X8U9|||http://purl.uniprot.org/uniprot/A0A2K5X987 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:RELN ^@ http://purl.uniprot.org/uniprot/A0A2K5U2N7|||http://purl.uniprot.org/uniprot/A0A2K5U2R6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the reelin family.|||Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Oligomer of disulfide-linked homodimers. Binds to the ectodomains of VLDLR and LRP8/APOER2.|||extracellular matrix http://togogenome.org/gene/9541:SLC9A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPS4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Interacts with CHP1 and CHP2.|||Membrane http://togogenome.org/gene/9541:HSPB6 ^@ http://purl.uniprot.org/uniprot/G7PXA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/9541:LOC102132338 ^@ http://purl.uniprot.org/uniprot/A0A2K5W038 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiA prenyltransferase family.|||Converts protoheme IX and farnesyl diphosphate to heme O.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9541:STK38L ^@ http://purl.uniprot.org/uniprot/A0A2K5USX8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:FUNDC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGS0|||http://purl.uniprot.org/uniprot/G8F3H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9541:RPL3 ^@ http://purl.uniprot.org/uniprot/Q25ND3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/9541:HGD ^@ http://purl.uniprot.org/uniprot/A0A2K5VXD4 ^@ Similarity ^@ Belongs to the homogentisate dioxygenase family. http://togogenome.org/gene/9541:CPA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCY7 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9541:ALKBH3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVC8 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9541:CTSO ^@ http://purl.uniprot.org/uniprot/A0A2K5U4I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9541:RRM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSY5 ^@ Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family. http://togogenome.org/gene/9541:MRPS26 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS26 family.|||Mitochondrion http://togogenome.org/gene/9541:HFE ^@ http://purl.uniprot.org/uniprot/A0A2K5UB06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MHC class I family.|||Binds TFR through the extracellular domain in a pH-dependent manner.|||Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.|||Cell membrane http://togogenome.org/gene/9541:TMEM54 ^@ http://purl.uniprot.org/uniprot/A0A2K5U810 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM54 family.|||Membrane http://togogenome.org/gene/9541:SLC2A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5URC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Endomembrane system|||Membrane|||perinuclear region http://togogenome.org/gene/9541:SLC35A5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Membrane http://togogenome.org/gene/9541:ATG2A ^@ http://purl.uniprot.org/uniprot/A0A2K5WDU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG2 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Preautophagosomal structure membrane http://togogenome.org/gene/9541:GNG2 ^@ http://purl.uniprot.org/uniprot/G7PA91 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9541:SLC66A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRX4|||http://purl.uniprot.org/uniprot/A0A2K5TRY9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:AK8 ^@ http://purl.uniprot.org/uniprot/Q4R3W4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Interacts with CFAP45 and CFAP52; CFAP45 and AK8 dimerization may create a cavity at the interface of the dimer that can accommodate AMP.|||Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.|||cilium axoneme|||cytosol http://togogenome.org/gene/9541:MFSD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V572 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:A4GALT ^@ http://purl.uniprot.org/uniprot/A0A2K5UQ83|||http://purl.uniprot.org/uniprot/A0A7N9CGC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 32 family.|||Golgi apparatus membrane http://togogenome.org/gene/9541:NUP50 ^@ http://purl.uniprot.org/uniprot/A0A8J8YJC8|||http://purl.uniprot.org/uniprot/Q4R414 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/9541:AKAP8L ^@ http://purl.uniprot.org/uniprot/A0A2K5VSJ8 ^@ Similarity ^@ Belongs to the AKAP95 family. http://togogenome.org/gene/9541:HGFAC ^@ http://purl.uniprot.org/uniprot/A0A2K5TZH3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ZFYVE16 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2G3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Early endosome membrane http://togogenome.org/gene/9541:ZNF397 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPL1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:COG3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V650 ^@ Function|||Similarity ^@ Belongs to the COG3 family.|||Involved in ER-Golgi transport. http://togogenome.org/gene/9541:RNF146 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVL0|||http://purl.uniprot.org/uniprot/A0A8J8YER2|||http://purl.uniprot.org/uniprot/Q2PFU6 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation (By similarity).|||Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.|||E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein (By similarity). Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos (By similarity). Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner (By similarity). Does not affect PARP1 activation. Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest (By similarity). Promotes cell survival after gamma-irradiation. Facilitates DNA repair (By similarity).|||E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.|||Nucleus|||The WWE domain mediates non-covalent poly(ADP-ribose)-binding.|||Ubiquitinated; autoubiquitinated.|||Ubiquitinated; autoubiquitinated. Autoubiquitination is enhanced upon poly(ADP-ribose)-binding (By similarity).|||cytosol http://togogenome.org/gene/9541:LOC102129634 ^@ http://purl.uniprot.org/uniprot/Q28477 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:RIPOR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2C1|||http://purl.uniprot.org/uniprot/A0A2K5U2K9 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the RIPOR family.|||Cell membrane|||Membrane|||cytoskeleton|||filopodium|||stereocilium membrane http://togogenome.org/gene/9541:RPL7A ^@ http://purl.uniprot.org/uniprot/G7NY07|||http://purl.uniprot.org/uniprot/Q4R5C2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Component of the large ribosomal subunit (By similarity). Interacts with CRY1 (By similarity). Interacts with DICER1, AGO2, TARBP2, MOV10 and EIF6; they form a large RNA-induced silencing complex (RISC) (By similarity).|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Component of the ribosome.|||Cytoplasm http://togogenome.org/gene/9541:ADGRF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIJ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SCNN1G ^@ http://purl.uniprot.org/uniprot/A0A2K5TNB0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102123651 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRE9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:SHROOM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/9541:PEX3 ^@ http://purl.uniprot.org/uniprot/G7P307|||http://purl.uniprot.org/uniprot/Q60HE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxin-3 family.|||Interacts with PEX19.|||Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes (By similarity).|||Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.|||Peroxisome membrane http://togogenome.org/gene/9541:KAT5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8L4|||http://purl.uniprot.org/uniprot/A0A2K5U8M2|||http://purl.uniprot.org/uniprot/A0A2K5U8P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9541:UCK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3M5 ^@ Similarity|||Subunit ^@ Belongs to the uridine kinase family.|||Homotetramer. http://togogenome.org/gene/9541:SHTN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W164|||http://purl.uniprot.org/uniprot/A0A2K5W1E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shootin family.|||axon|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9541:RBM5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWT9|||http://purl.uniprot.org/uniprot/A0A7N9CXB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBM5/RBM10 family.|||Nucleus http://togogenome.org/gene/9541:YAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4U1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP300 family.|||Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.|||Cytoplasm http://togogenome.org/gene/9541:GPR65 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMR2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:CDR2L ^@ http://purl.uniprot.org/uniprot/A0A2K5WUR8 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/9541:RRH ^@ http://purl.uniprot.org/uniprot/A0A8J8XE25|||http://purl.uniprot.org/uniprot/G7P633 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9541:TLCD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUC6|||http://purl.uniprot.org/uniprot/A0A7N9IBL8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TOE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZM3 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/9541:TNNT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPF7|||http://purl.uniprot.org/uniprot/A0A2K5WPG3|||http://purl.uniprot.org/uniprot/A0A2K5WPH1|||http://purl.uniprot.org/uniprot/A0A2K5WPK1|||http://purl.uniprot.org/uniprot/A0A2K5WPQ7|||http://purl.uniprot.org/uniprot/A0A2K5WPQ9|||http://purl.uniprot.org/uniprot/A0A2K5WPT0 ^@ Function|||Similarity ^@ Belongs to the troponin T family.|||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/9541:TNFRSF10D ^@ http://purl.uniprot.org/uniprot/A0A2K5UMS0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:BYSL ^@ http://purl.uniprot.org/uniprot/A0A2K5V744 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/9541:LOC102133545 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:NTNG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR42|||http://purl.uniprot.org/uniprot/A0A2K5TR45 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:CENPK ^@ http://purl.uniprot.org/uniprot/A0A8J8Y6U8|||http://purl.uniprot.org/uniprot/G7P7M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-K/MCM22 family.|||Nucleus|||centromere http://togogenome.org/gene/9541:COPS8 ^@ http://purl.uniprot.org/uniprot/A0A8J8XCZ2|||http://purl.uniprot.org/uniprot/G7PKD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN8 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:MSH6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6G0 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR). http://togogenome.org/gene/9541:GIMD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UD94 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9541:SIRT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVV3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the sirtuin family. Class I subfamily.|||Binds 1 zinc ion per subunit.|||NAD-dependent protein deacetylase. http://togogenome.org/gene/9541:RPE ^@ http://purl.uniprot.org/uniprot/A0A2K5TU71|||http://purl.uniprot.org/uniprot/A0A7N9CE89 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/9541:KCTD21 ^@ http://purl.uniprot.org/uniprot/A0A7N9CEL6|||http://purl.uniprot.org/uniprot/A0A8J8XEA7 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:FBXO15 ^@ http://purl.uniprot.org/uniprot/Q9GKV7 ^@ Function|||Subunit ^@ Directly interacts with SKP1 and CUL1.|||Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. http://togogenome.org/gene/9541:RFTN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7N3|||http://purl.uniprot.org/uniprot/G7PL43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102141626 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIP2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:CENPH ^@ http://purl.uniprot.org/uniprot/A0A2K5W8L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-H/MCM16 family.|||Nucleus|||kinetochore http://togogenome.org/gene/9541:LOC102128376 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWQ5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M2 family.|||Binds 2 Zn(2+) ions per subunit. http://togogenome.org/gene/9541:NKX2-2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFK2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:VANGL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ83|||http://purl.uniprot.org/uniprot/A0A8J8YP28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ISOC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIT7 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/9541:SMAD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VW79|||http://purl.uniprot.org/uniprot/G7PWR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:FAM135A ^@ http://purl.uniprot.org/uniprot/A0A2K5TX22|||http://purl.uniprot.org/uniprot/A0A2K5TX25|||http://purl.uniprot.org/uniprot/A0A2K5TX30|||http://purl.uniprot.org/uniprot/A0A7N9DGC9 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/9541:LOC102123571 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBY7 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9541:LOC102120633 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1S5|||http://purl.uniprot.org/uniprot/A0A2K5X1W3|||http://purl.uniprot.org/uniprot/A0A2K5X1W8|||http://purl.uniprot.org/uniprot/A0A2K5X2E4|||http://purl.uniprot.org/uniprot/A0A7N9CB00 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/9541:INPP4A ^@ http://purl.uniprot.org/uniprot/A0A2K5V828|||http://purl.uniprot.org/uniprot/A0A2K5V832|||http://purl.uniprot.org/uniprot/A0A2K5V842|||http://purl.uniprot.org/uniprot/A0A2K5V8G5 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/9541:CACNA2D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRT5|||http://purl.uniprot.org/uniprot/A0A2K5VRW1|||http://purl.uniprot.org/uniprot/A0A7N9ICS8 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/9541:SLC7A10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVA6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GBP6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WE26 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9541:ASB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPA1 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:CETN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDL5 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/9541:HEATR5B ^@ http://purl.uniprot.org/uniprot/A0A2K5V267|||http://purl.uniprot.org/uniprot/A0A8J8XGY1|||http://purl.uniprot.org/uniprot/G7PM09 ^@ Similarity ^@ Belongs to the HEATR5 family. http://togogenome.org/gene/9541:RRP36 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAK0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with 90S and pre-40S pre-ribosomal particles.|||Belongs to the RRP36 family.|||Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.|||nucleolus http://togogenome.org/gene/9541:TDRD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUI0|||http://purl.uniprot.org/uniprot/A0A2K5VUJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TDRD5 family.|||Cytoplasm|||Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly. http://togogenome.org/gene/9541:LOC102125991 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNV7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:CAB39 ^@ http://purl.uniprot.org/uniprot/A0A8J8XGX5|||http://purl.uniprot.org/uniprot/G7PK94 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/9541:PFDN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMI8|||http://purl.uniprot.org/uniprot/A0A7N9CDD8|||http://purl.uniprot.org/uniprot/G7P8G2 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/9541:KCNC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZS0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:YIF1A ^@ http://purl.uniprot.org/uniprot/A0A2K5V2P5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:GSPT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIW9 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. http://togogenome.org/gene/9541:PPEF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRM0 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/9541:PRKCD ^@ http://purl.uniprot.org/uniprot/G7NZU6 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.|||Cytoplasm|||Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.|||Nucleus|||perinuclear region http://togogenome.org/gene/9541:MCEE ^@ http://purl.uniprot.org/uniprot/A0A2K5WLL5 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/9541:ADCY8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TT43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9541:SLC52A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSG3|||http://purl.uniprot.org/uniprot/G8F5V8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/9541:LMNB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VC86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||Nucleus lamina http://togogenome.org/gene/9541:DOCK9 ^@ http://purl.uniprot.org/uniprot/A0A2K5WA66 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9541:LOC102120351 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5F7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9541:CNN1 ^@ http://purl.uniprot.org/uniprot/G7PZF6 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/9541:SF3B4 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0H7|||http://purl.uniprot.org/uniprot/G7NTS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B4 family.|||Nucleus http://togogenome.org/gene/9541:KEG98_p11 ^@ http://purl.uniprot.org/uniprot/C3W4Y7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:MYD88 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVT5|||http://purl.uniprot.org/uniprot/I7GLV7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.|||Cytoplasm|||Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. http://togogenome.org/gene/9541:ESF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W390 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF1 family.|||nucleolus http://togogenome.org/gene/9541:CLIC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WP59 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cell membrane|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9541:FABP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YM21|||http://purl.uniprot.org/uniprot/G7P666 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm|||FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. http://togogenome.org/gene/9541:APOB ^@ http://purl.uniprot.org/uniprot/A0A2K5TN82 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:GOSR1 ^@ http://purl.uniprot.org/uniprot/A0A7N9DD30 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GOSR1 family.|||Component of several multiprotein Golgi SNARE complexes.|||Golgi apparatus membrane|||Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.|||Membrane http://togogenome.org/gene/9541:PLEKHJ1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHF9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sesquipedalian family.|||Early endosome|||Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.|||Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.|||Recycling endosome|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/9541:GRIK4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1S8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9541:SPATA6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5E4 ^@ Similarity ^@ Belongs to the SPATA6 family. http://togogenome.org/gene/9541:TMEM47 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/9541:DMPK ^@ http://purl.uniprot.org/uniprot/A0A2K5WJU6|||http://purl.uniprot.org/uniprot/A0A2K5WK21 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. http://togogenome.org/gene/9541:GALNTL6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:PLD3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQT5|||http://purl.uniprot.org/uniprot/G7PXL5 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9541:NAIF1 ^@ http://purl.uniprot.org/uniprot/G8F552|||http://purl.uniprot.org/uniprot/Q9BE21 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAIF1 family.|||Induces apoptosis.|||Interacts with HARBI1.|||Nucleus http://togogenome.org/gene/9541:NMT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4N9|||http://purl.uniprot.org/uniprot/A0A2K5X4P4 ^@ Function|||Similarity ^@ Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.|||Belongs to the NMT family. http://togogenome.org/gene/9541:NDUFS6 ^@ http://purl.uniprot.org/uniprot/Q4R5X8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS6 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ERN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0L5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:KCNK10 ^@ http://purl.uniprot.org/uniprot/A0A2K5W234|||http://purl.uniprot.org/uniprot/A0A8J8YKE1|||http://purl.uniprot.org/uniprot/G7PB47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9541:WDR12 ^@ http://purl.uniprot.org/uniprot/I7GK27 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat WDR12/YTM1 family.|||Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.|||Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9541:CDC25B ^@ http://purl.uniprot.org/uniprot/A0A2K5TVD5|||http://purl.uniprot.org/uniprot/A0A2K5TVE0 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/9541:GABRB1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YGX5|||http://purl.uniprot.org/uniprot/G7P5I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:ITIH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WR32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9541:ATL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X807|||http://purl.uniprot.org/uniprot/Q60HD2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.|||Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.|||Endoplasmic reticulum membrane|||GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development.|||Golgi apparatus membrane|||Monomer as apoprotein and in the GDP-bound form. Homodimer in the GTP-bound form. Interacts (via N-terminal region) with MAP4K4 (via CNH regulatory domain). Interacts with REEP5, RTN3 and RTN4 (via the transmembrane region). Interacts with SPAST; interaction is direct. Interacts with REEP1. Interacts with CPT1C. Interacts with ARL6IP1. Interacts with ZFYVE27.|||axon http://togogenome.org/gene/9541:BABAM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPL4|||http://purl.uniprot.org/uniprot/I7G8X0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BABAM1 family.|||Nucleus http://togogenome.org/gene/9541:DHDDS ^@ http://purl.uniprot.org/uniprot/A0A2K5TPV3|||http://purl.uniprot.org/uniprot/A0A2K5TPX8|||http://purl.uniprot.org/uniprot/G7NWT5 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/9541:AQP11 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|||Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.|||Membrane http://togogenome.org/gene/9541:TLR7 ^@ http://purl.uniprot.org/uniprot/B3Y652|||http://purl.uniprot.org/uniprot/G7Q281 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9541:STAT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5E9|||http://purl.uniprot.org/uniprot/A0A2K5W5J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:PCYOX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQJ3 ^@ Similarity ^@ Belongs to the prenylcysteine oxidase family. http://togogenome.org/gene/9541:GJB6 ^@ http://purl.uniprot.org/uniprot/G7PVT9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9541:PRL ^@ http://purl.uniprot.org/uniprot/A0A2K5X975|||http://purl.uniprot.org/uniprot/G7P4J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/9541:SETD7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TY36|||http://purl.uniprot.org/uniprot/A0A2K5TYA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.|||Chromosome|||Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.|||Nucleus http://togogenome.org/gene/9541:TRIP10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNBP1 family.|||Cell membrane|||Lysosome|||Membrane|||cell cortex http://togogenome.org/gene/9541:CLN8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFP0|||http://purl.uniprot.org/uniprot/G7PCB7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SGMS2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YSC0|||http://purl.uniprot.org/uniprot/G7P620|||http://purl.uniprot.org/uniprot/Q4R763 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Cell membrane|||Golgi apparatus membrane|||Membrane|||Palmitoylated on Cys-331, Cys-332, Cys-343 and Cys-348; which plays an important role in plasma membrane localization.|||Sphingomyelin synthase that primarily contributes to sphingomyelin synthesis and homeostasis at the plasma membrane. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction appears to depend on the levels of CER and DAG in the plasma membrane. Does not use free phosphorylcholine or CDP-choline as donors. Can also transfer phosphoethanolamine head group of phosphatidylethanolamine (PE) on to ceramide (CER) to form ceramide phosphoethanolamine (CPE). Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting. To a lesser extent, plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1. Required for normal bone matrix mineralization. http://togogenome.org/gene/9541:TRIM54 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLK1 ^@ Function|||Subcellular Location Annotation ^@ May bind and stabilize microtubules during myotubes formation.|||Nucleus|||Z line http://togogenome.org/gene/9541:MGAT4A ^@ http://purl.uniprot.org/uniprot/G7PMT1|||http://purl.uniprot.org/uniprot/Q4R854 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 54 family.|||Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (By similarity).|||Golgi apparatus membrane|||Inhibited by UDP.|||Membrane|||N-glycosylated.|||Secreted http://togogenome.org/gene/9541:APOL2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CF82|||http://purl.uniprot.org/uniprot/Q2PFL3 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9541:CSRNP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPS8|||http://purl.uniprot.org/uniprot/G7PIB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/9541:MMAA ^@ http://purl.uniprot.org/uniprot/A0A2K5V0N3 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/9541:MTFR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNN6|||http://purl.uniprot.org/uniprot/G7P334 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/9541:VEGFD ^@ http://purl.uniprot.org/uniprot/A0A8J8Y018|||http://purl.uniprot.org/uniprot/G7Q297 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/9541:ACSM3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN34 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9541:CD44 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIV5|||http://purl.uniprot.org/uniprot/A0A2K5VJ36|||http://purl.uniprot.org/uniprot/A0A2K5VJ78 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||microvillus http://togogenome.org/gene/9541:TMEM167A ^@ http://purl.uniprot.org/uniprot/A0A7N9DD82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Membrane http://togogenome.org/gene/9541:LOC102131829 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/9541:ACTR6 ^@ http://purl.uniprot.org/uniprot/G7PJA1 ^@ Similarity ^@ Belongs to the actin family. ARP6 subfamily. http://togogenome.org/gene/9541:SFRP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4U9 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:KIF20A ^@ http://purl.uniprot.org/uniprot/A0A2K5WY13 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:ABHD8 ^@ http://purl.uniprot.org/uniprot/Q4R584 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. http://togogenome.org/gene/9541:TNPO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WC55|||http://purl.uniprot.org/uniprot/A0A2K5WCI7|||http://purl.uniprot.org/uniprot/A0A2K5WCL6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:NOX4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX81|||http://purl.uniprot.org/uniprot/A0A2K5TX86|||http://purl.uniprot.org/uniprot/A0A2K5TX98 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CTSV ^@ http://purl.uniprot.org/uniprot/A0A7N9CX13|||http://purl.uniprot.org/uniprot/G7PSS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9541:SH3BGRL2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CI10 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/9541:ACSS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WID2|||http://purl.uniprot.org/uniprot/A0A2K5WID8|||http://purl.uniprot.org/uniprot/A0A2K5WIE2|||http://purl.uniprot.org/uniprot/A0A7N9CN34 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9541:NUMBL ^@ http://purl.uniprot.org/uniprot/A0A2K5UJC2 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Plays a role in the process of neurogenesis. http://togogenome.org/gene/9541:MMACHC ^@ http://purl.uniprot.org/uniprot/A0A2K5U3Q3|||http://purl.uniprot.org/uniprot/G7NV00 ^@ Similarity ^@ Belongs to the MMACHC family. http://togogenome.org/gene/9541:RNF20 ^@ http://purl.uniprot.org/uniprot/A0A2K5WX05 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.|||Nucleus http://togogenome.org/gene/9541:OSBPL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UP32|||http://purl.uniprot.org/uniprot/G7PFQ2 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9541:TADA2A ^@ http://purl.uniprot.org/uniprot/A0A2K5WT76|||http://purl.uniprot.org/uniprot/G7PUJ2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:RIDA ^@ http://purl.uniprot.org/uniprot/A0A8J8YT39|||http://purl.uniprot.org/uniprot/G7PCA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RutC family.|||Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.|||Peroxisome http://togogenome.org/gene/9541:SEC61B ^@ http://purl.uniprot.org/uniprot/A0A2K5TY58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/9541:PNKD ^@ http://purl.uniprot.org/uniprot/A0A2K5TS50|||http://purl.uniprot.org/uniprot/I7G6D8 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/9541:MIS12 ^@ http://purl.uniprot.org/uniprot/I7GDZ8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mis12 family.|||Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.|||kinetochore http://togogenome.org/gene/9541:PIGH ^@ http://purl.uniprot.org/uniprot/A0A2K5TS98|||http://purl.uniprot.org/uniprot/G8F4W5 ^@ Similarity ^@ Belongs to the PIGH family. http://togogenome.org/gene/9541:LOC102123072 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJS7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9541:ARFGEF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5URX1 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||perinuclear region http://togogenome.org/gene/9541:MRPS7 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y331|||http://purl.uniprot.org/uniprot/G7PVD9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/9541:ABCD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9541:MS4A13 ^@ http://purl.uniprot.org/uniprot/G7PPZ9 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9541:ANAPC10 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8L7|||http://purl.uniprot.org/uniprot/A0A7N9IH85|||http://purl.uniprot.org/uniprot/I7GEV9 ^@ Function|||Similarity ^@ Belongs to the APC10 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/9541:NUDT19 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0G6 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/9541:RAMP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VU67|||http://purl.uniprot.org/uniprot/I7G3H4 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/9541:CA5B ^@ http://purl.uniprot.org/uniprot/A0A2K5WNP4 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9541:TXLNG ^@ http://purl.uniprot.org/uniprot/G7Q2B0 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9541:STAG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5USA8|||http://purl.uniprot.org/uniprot/A0A2K5USH6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/9541:MIXL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKV7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PTH2R ^@ http://purl.uniprot.org/uniprot/A0A2K5X9H0|||http://purl.uniprot.org/uniprot/G7PLB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GBX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYD4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SLC10A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBR1|||http://purl.uniprot.org/uniprot/A0A2K5VBV0|||http://purl.uniprot.org/uniprot/A0A8J8XN72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9541:UBR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY27 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/9541:PAGE4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3Q9 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9541:E2F6 ^@ http://purl.uniprot.org/uniprot/Q95KG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9541:TRMO ^@ http://purl.uniprot.org/uniprot/A0A2K5VSX4 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/9541:LOC101926003 ^@ http://purl.uniprot.org/uniprot/A0A7N9D8L8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with UHRF2/NIRF.|||May be involved in cell cycle regulation.|||Nucleus http://togogenome.org/gene/9541:TFAP2D ^@ http://purl.uniprot.org/uniprot/A0A8J8YE07|||http://purl.uniprot.org/uniprot/G7P4U7 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9541:BCL2L13 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXQ7|||http://purl.uniprot.org/uniprot/A0A2K5VXX2 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9541:GTF2A1L ^@ http://purl.uniprot.org/uniprot/Q4R6W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus http://togogenome.org/gene/9541:HOXC10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9541:GBP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WE89 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9541:ADGRG7 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8Z4|||http://purl.uniprot.org/uniprot/A0A2K5X9E2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NBR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U721 ^@ Subcellular Location Annotation ^@ autophagosome http://togogenome.org/gene/9541:STX17 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDT2|||http://purl.uniprot.org/uniprot/G7PRU5|||http://purl.uniprot.org/uniprot/I7GBM2 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9541:TMPRSS11D ^@ http://purl.uniprot.org/uniprot/A0A2K5VAF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9541:BORCS5 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6D4|||http://purl.uniprot.org/uniprot/I7GLI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS5 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9541:BBOF1 ^@ http://purl.uniprot.org/uniprot/Q4R7Y8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues (By similarity).|||Belongs to the BBOF1 family.|||cilium basal body http://togogenome.org/gene/9541:BATF ^@ http://purl.uniprot.org/uniprot/A0A8J8XHF4|||http://purl.uniprot.org/uniprot/G7PB13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family.|||Cytoplasm http://togogenome.org/gene/9541:MT2A ^@ http://purl.uniprot.org/uniprot/G7Q161|||http://purl.uniprot.org/uniprot/P68303 ^@ Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.|||This metallothionein binds zinc. http://togogenome.org/gene/9541:CRABP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJ89|||http://purl.uniprot.org/uniprot/G7NV96 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:EPOR ^@ http://purl.uniprot.org/uniprot/A0A2K5WKK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Forms homodimers on EPO stimulation.|||Membrane|||Receptor for erythropoietin. http://togogenome.org/gene/9541:TAF9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VD20|||http://purl.uniprot.org/uniprot/A0A8J8Y5T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/9541:LOC102130453 ^@ http://purl.uniprot.org/uniprot/Q4R7H4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NOSIP family.|||Cytoplasm|||E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (By similarity).|||Interacts with NOS1 and NOS3 (By similarity). Interacts with PP2A holoenzyme, containing PPP2CA, PPP2CB, PPP2R1A and PPP2R2A subunits (By similarity).|||Nucleus|||The U-box-like region is a truncated U-box domain. It is unknown whether it is functional or not. http://togogenome.org/gene/9541:PCSK2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YR00|||http://purl.uniprot.org/uniprot/G7PH08 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9541:USP45 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNX1 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9541:CYRIB ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ03|||http://purl.uniprot.org/uniprot/A0A2K5VZ07|||http://purl.uniprot.org/uniprot/G7PCU4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CYRI family.|||Interacts with RAC1 (GTP-bound form preferentially).|||Membrane http://togogenome.org/gene/9541:SUZ12 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZR7|||http://purl.uniprot.org/uniprot/A0A2K5X054 ^@ Similarity ^@ Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family. http://togogenome.org/gene/9541:ZSCAN20 ^@ http://purl.uniprot.org/uniprot/A0A2K5TS95|||http://purl.uniprot.org/uniprot/A0A2K5TSB1 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:CD99 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8L6|||http://purl.uniprot.org/uniprot/I7GEX8 ^@ Similarity ^@ Belongs to the CD99 family. http://togogenome.org/gene/9541:RCL1 ^@ http://purl.uniprot.org/uniprot/A0A7N9D8I9|||http://purl.uniprot.org/uniprot/A0A8J8Y2J1|||http://purl.uniprot.org/uniprot/G7PSF4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.|||Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.|||nucleolus http://togogenome.org/gene/9541:DENND11 ^@ http://purl.uniprot.org/uniprot/I7GMF7 ^@ Similarity ^@ Belongs to the DENND11 family. http://togogenome.org/gene/9541:SLC12A6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGK5|||http://purl.uniprot.org/uniprot/A0A2K5UGN1|||http://purl.uniprot.org/uniprot/A0A2K5UGS1|||http://purl.uniprot.org/uniprot/A0A2K5UGV2|||http://purl.uniprot.org/uniprot/A0A2K5UH02|||http://purl.uniprot.org/uniprot/A0A8J8Y5I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9541:PLPP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9541:C9H10orf90 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWH8 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/9541:CALU ^@ http://purl.uniprot.org/uniprot/A0A8J8YKQ2|||http://purl.uniprot.org/uniprot/G7P0M0|||http://purl.uniprot.org/uniprot/I7G7Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CREC family.|||Endoplasmic reticulum membrane|||Golgi apparatus|||Melanosome|||Membrane|||Sarcoplasmic reticulum lumen|||Secreted http://togogenome.org/gene/9541:PSMC3 ^@ http://purl.uniprot.org/uniprot/I7GLY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:IPO13 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y1H8|||http://purl.uniprot.org/uniprot/G7NUX7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the importin beta family.|||Cytoplasm|||Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.|||Nucleus http://togogenome.org/gene/9541:ELK4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQ43|||http://purl.uniprot.org/uniprot/G7NVC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:LOC101864785 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULD9 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9541:ZPLD1 ^@ http://purl.uniprot.org/uniprot/Q95JJ6 ^@ Function|||PTM|||Subcellular Location Annotation ^@ Cytoplasmic vesicle membrane|||Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ.|||Proteolytically cleaved before the transmembrane segment to yield the secreted form found in the extracellular matrix of the cupula.|||extracellular matrix http://togogenome.org/gene/9541:KDM3B ^@ http://purl.uniprot.org/uniprot/A0A2K5WEG0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MED14 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAQ7|||http://purl.uniprot.org/uniprot/A0A7N9CK46 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 14 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9541:STAR ^@ http://purl.uniprot.org/uniprot/A0A2K5UU11 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ May interact with TSPO.|||Mitochondrion|||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. http://togogenome.org/gene/9541:SLC37A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNT9|||http://purl.uniprot.org/uniprot/A0A2K5WNY8|||http://purl.uniprot.org/uniprot/G7P0Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/9541:SLC10A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TN65 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane|||Monomer and homodimer. http://togogenome.org/gene/9541:LDLRAD4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UA62|||http://purl.uniprot.org/uniprot/A0A8J8YC76|||http://purl.uniprot.org/uniprot/G7PWB5|||http://purl.uniprot.org/uniprot/I7G4V1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMEPA1 family.|||Early endosome membrane|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:FAM13C ^@ http://purl.uniprot.org/uniprot/A0A2K5VNU4 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9541:CCDC172 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC172 family.|||Cytoplasm http://togogenome.org/gene/9541:TUBA8 ^@ http://purl.uniprot.org/uniprot/I7GJE7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/9541:PIGU ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGU family.|||Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:GDF6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X608 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9541:TRAF5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZV0|||http://purl.uniprot.org/uniprot/A0A2K5X0F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9541:JMY ^@ http://purl.uniprot.org/uniprot/A0A2K5VQ04 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CCNO ^@ http://purl.uniprot.org/uniprot/A0A2K5UVB7 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9541:NOP53 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP53 family.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9541:FARSA ^@ http://purl.uniprot.org/uniprot/A0A2K5UR88 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. http://togogenome.org/gene/9541:INSL4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ81 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:NFS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRT2 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/9541:SLC41A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWR7|||http://purl.uniprot.org/uniprot/G7NVC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9541:DUSP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCI6 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9541:ETFB ^@ http://purl.uniprot.org/uniprot/A0A2K5U9R3|||http://purl.uniprot.org/uniprot/I7GJM6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF beta-subunit/FixA family.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/9541:EIF4ENIF1 ^@ http://purl.uniprot.org/uniprot/G7PF88 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:RPL37A ^@ http://purl.uniprot.org/uniprot/A0A2K5UQV8|||http://purl.uniprot.org/uniprot/A0A7N9D9L4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/9541:ELOC ^@ http://purl.uniprot.org/uniprot/A0A2K5WLS2|||http://purl.uniprot.org/uniprot/A0A2K5WM01 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/9541:PHAF1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YPC1|||http://purl.uniprot.org/uniprot/G7Q1C4 ^@ Similarity ^@ Belongs to the PHAF1 family. http://togogenome.org/gene/9541:GNPDA2 ^@ http://purl.uniprot.org/uniprot/A0A7N9D3Q0|||http://purl.uniprot.org/uniprot/A0A8J8YT43|||http://purl.uniprot.org/uniprot/G7P5I3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/9541:CDC42EP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9541:DGKB ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ25|||http://purl.uniprot.org/uniprot/A0A2K5VZ56 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9541:KCNK5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9541:PDE7B ^@ http://purl.uniprot.org/uniprot/A0A2K5V537|||http://purl.uniprot.org/uniprot/A0A2K5V567 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:EXOC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMF7 ^@ Function|||Similarity ^@ Belongs to the SEC10 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9541:LOC102134759 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2I4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:SRSF5 ^@ http://purl.uniprot.org/uniprot/A0A8J8YSA4|||http://purl.uniprot.org/uniprot/G7PAR3 ^@ Similarity ^@ Belongs to the splicing factor SR family. http://togogenome.org/gene/9541:TBX6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U947 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:KCNJ14 ^@ http://purl.uniprot.org/uniprot/A0A2K5VU53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9541:CADM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0W6|||http://purl.uniprot.org/uniprot/A0A2K5U0X1 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9541:SLC4A7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UB14|||http://purl.uniprot.org/uniprot/A0A2K5UB60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Membrane http://togogenome.org/gene/9541:LOC107126432 ^@ http://purl.uniprot.org/uniprot/A0A2K5USP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PET117 family.|||Mitochondrion http://togogenome.org/gene/9541:CEPT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VL08|||http://purl.uniprot.org/uniprot/A0A2K5VL10|||http://purl.uniprot.org/uniprot/A0A8J8YNT5|||http://purl.uniprot.org/uniprot/G7NW49 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/9541:SDR9C7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WES2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:MTNR1B ^@ http://purl.uniprot.org/uniprot/C9WT50|||http://purl.uniprot.org/uniprot/G7PNG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ATP6V1E2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFX9 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/9541:RARB ^@ http://purl.uniprot.org/uniprot/A0A2K5WS97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:LOC102122033 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9H0|||http://purl.uniprot.org/uniprot/A0A2K5W9I7|||http://purl.uniprot.org/uniprot/G7P5C2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/9541:AP1M1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Golgi apparatus|||Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9541:OSBPL11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPP6|||http://purl.uniprot.org/uniprot/G7NVZ4 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9541:ATP5F1C ^@ http://purl.uniprot.org/uniprot/A0A2K5UQ24|||http://purl.uniprot.org/uniprot/A0A8J8YNN1|||http://purl.uniprot.org/uniprot/G7PE66|||http://purl.uniprot.org/uniprot/Q4R5B0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ZNF165 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSG8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MAGT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:TLR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WT39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9541:ZFHX4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBJ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:HACD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TS12 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:MB ^@ http://purl.uniprot.org/uniprot/G7PFA9|||http://purl.uniprot.org/uniprot/P02150 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/9541:STARD9 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLW8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:PEX16 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-16 family.|||Peroxisome membrane http://togogenome.org/gene/9541:COG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U426|||http://purl.uniprot.org/uniprot/A0A7N9CLA2|||http://purl.uniprot.org/uniprot/G8F2E0 ^@ Similarity ^@ Belongs to the COG2 family. http://togogenome.org/gene/9541:MAP3K5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLI0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/9541:KCNJ8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WG71|||http://purl.uniprot.org/uniprot/G8F4D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9541:KLC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WV81|||http://purl.uniprot.org/uniprot/G7PXW7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/9541:PARP12 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHU5 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9541:FGF12 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKY5|||http://purl.uniprot.org/uniprot/A0A2K5TKY9|||http://purl.uniprot.org/uniprot/A0A8J8XQD2|||http://purl.uniprot.org/uniprot/G7NYQ4 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:DUSP16 ^@ http://purl.uniprot.org/uniprot/A0A2K5U262 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9541:SPOCK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WM35 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:GABRE ^@ http://purl.uniprot.org/uniprot/A0A2K5WCD4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:TMEM88 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4M8|||http://purl.uniprot.org/uniprot/G7PTJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM88 family.|||Membrane http://togogenome.org/gene/9541:ASB14 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3I0 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:MCM8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VML5|||http://purl.uniprot.org/uniprot/A0A2K5VMP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9541:ERLIN1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YBL7|||http://purl.uniprot.org/uniprot/G7PDQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the band 7/mec-2 family.|||Endoplasmic reticulum membrane|||Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.|||Membrane http://togogenome.org/gene/9541:C20H16orf87 ^@ http://purl.uniprot.org/uniprot/A0A7N9CKG3 ^@ Similarity ^@ Belongs to the UPF0547 family. http://togogenome.org/gene/9541:IL17RB ^@ http://purl.uniprot.org/uniprot/A0A2K5TUM4|||http://purl.uniprot.org/uniprot/G7NZU1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:NXPH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3I2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9541:SAE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRX3|||http://purl.uniprot.org/uniprot/I7GJM9 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9541:ATP4B ^@ http://purl.uniprot.org/uniprot/A0A8J8XPL0|||http://purl.uniprot.org/uniprot/G7PVS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9541:NETO1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XHI9|||http://purl.uniprot.org/uniprot/Q2PFY8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:STX10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Golgi apparatus membrane http://togogenome.org/gene/9541:TMEM150A ^@ http://purl.uniprot.org/uniprot/A0A2K5WBZ6|||http://purl.uniprot.org/uniprot/A0A8J8YQX1|||http://purl.uniprot.org/uniprot/G7PMM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRAM/TMEM150 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:NKAPL ^@ http://purl.uniprot.org/uniprot/A0A7N9CJD0 ^@ Similarity ^@ Belongs to the NKAP family. http://togogenome.org/gene/9541:CDH4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYM4 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SLC45A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQN9|||http://purl.uniprot.org/uniprot/Q95KI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.|||Membrane|||Proton-associated sucrose transporter. May be able to transport also glucose and fructose. http://togogenome.org/gene/9541:ARMCX3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CXV7|||http://purl.uniprot.org/uniprot/A0A8J8XM55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eutherian X-chromosome-specific Armcx family.|||Membrane http://togogenome.org/gene/9541:GJB3 ^@ http://purl.uniprot.org/uniprot/G7NTG3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9541:PDCL ^@ http://purl.uniprot.org/uniprot/A0A2K5W0N3 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9541:ACOX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/9541:EYA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X553 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9541:PA2G4 ^@ http://purl.uniprot.org/uniprot/I7GJ62 ^@ Similarity ^@ Belongs to the peptidase M24 family. http://togogenome.org/gene/9541:MAST4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X668 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9541:ALDOB ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5A0|||http://purl.uniprot.org/uniprot/G7PRT5 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9541:LOC102146966 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJM6|||http://purl.uniprot.org/uniprot/A0A7N9CDA4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102138163 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKE2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CLPTM1L ^@ http://purl.uniprot.org/uniprot/A0A2K5WYJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLPTM1 family.|||Membrane http://togogenome.org/gene/9541:KCNA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDR0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:TLR6 ^@ http://purl.uniprot.org/uniprot/B3Y645 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:CD8B ^@ http://purl.uniprot.org/uniprot/A0A2K5X6I2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:HSPA2 ^@ http://purl.uniprot.org/uniprot/G7PAI9 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9541:SLC30A1 ^@ http://purl.uniprot.org/uniprot/Q4R6K2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Basolateral cell membrane|||Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Homodimer.|||Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (By similarity). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (By similarity). http://togogenome.org/gene/9541:FAM20A ^@ http://purl.uniprot.org/uniprot/A0A2K5V7D2 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/9541:SCAMP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9541:RNF13 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102137053 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUC3|||http://purl.uniprot.org/uniprot/Q4R2X7 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9541:HYAL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X9F6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9541:C5AR1 ^@ http://purl.uniprot.org/uniprot/A0A7N9IEK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane http://togogenome.org/gene/9541:CDK2AP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6H8|||http://purl.uniprot.org/uniprot/A0A7N9CEQ4|||http://purl.uniprot.org/uniprot/G8F6F5 ^@ Similarity ^@ Belongs to the CDK2AP family. http://togogenome.org/gene/9541:APOOL ^@ http://purl.uniprot.org/uniprot/A0A2K5W1P9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:GALNT17 ^@ http://purl.uniprot.org/uniprot/A0A2K5VN50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:ANKH ^@ http://purl.uniprot.org/uniprot/A0A2K5WPU8|||http://purl.uniprot.org/uniprot/A0A7N9CB57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANKH family.|||Membrane|||Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter. http://togogenome.org/gene/9541:SLC5A12 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4K9|||http://purl.uniprot.org/uniprot/G7PQI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9541:CHMP1A ^@ http://purl.uniprot.org/uniprot/A0A2K5WKS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF7 family.|||Cytoplasm|||Endosome membrane|||Membrane http://togogenome.org/gene/9541:PRKAR2B ^@ http://purl.uniprot.org/uniprot/A0A2K5WX89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:STAB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGV1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PPM1D ^@ http://purl.uniprot.org/uniprot/Q4R8H7 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9541:SLC35A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U963 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Membrane http://togogenome.org/gene/9541:TXLNB ^@ http://purl.uniprot.org/uniprot/A0A2K5TMT4 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9541:LOC102126841 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SCAP family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/9541:ESCO2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNS5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:HAPLN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WER6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:RELT ^@ http://purl.uniprot.org/uniprot/A0A2K5V4T4|||http://purl.uniprot.org/uniprot/Q9N092 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RELT family.|||Cell membrane|||Cytoplasm|||Interacts with RELL1, RELL2, OXSR1, PLSCR1 and STK39.|||May play a role in apoptosis. Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed. Involved in dental enamel formation.|||Phosphorylated in vitro by OXSR1. Phosphorylated by STK39.|||perinuclear region http://togogenome.org/gene/9541:CTNND2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VL88 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9541:RHBDD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7I5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102117755 ^@ http://purl.uniprot.org/uniprot/A0A7N9CEQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:KIF3C ^@ http://purl.uniprot.org/uniprot/A0A8J8XNX6|||http://purl.uniprot.org/uniprot/G7PLS9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:ESCO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W278|||http://purl.uniprot.org/uniprot/A0A7N9CRD6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FGF4 ^@ http://purl.uniprot.org/uniprot/A0A7N9D0H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Secreted http://togogenome.org/gene/9541:CLNS1A ^@ http://purl.uniprot.org/uniprot/A0A2K5VE65|||http://purl.uniprot.org/uniprot/G8F520 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pICln (TC 1.A.47) family.|||Nucleus http://togogenome.org/gene/9541:WDFY1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRH3 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9541:ACSL6 ^@ http://purl.uniprot.org/uniprot/Q4R450 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:CLDN7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WU76 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:PHTF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V766|||http://purl.uniprot.org/uniprot/A0A2K5V778 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NOTUM ^@ http://purl.uniprot.org/uniprot/A0A2K5TM66 ^@ Similarity ^@ Belongs to the pectinacetylesterase family. Notum subfamily. http://togogenome.org/gene/9541:SMDT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XLW1|||http://purl.uniprot.org/uniprot/G7PFP7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMDT1/EMRE family.|||Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.|||Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:EML4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VE68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat EMAP family.|||cytoskeleton http://togogenome.org/gene/9541:SHMT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHN6 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/9541:TMEM150B ^@ http://purl.uniprot.org/uniprot/A0A8J8XUG3|||http://purl.uniprot.org/uniprot/G7PYY7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:DRD1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XEQ4|||http://purl.uniprot.org/uniprot/G7P6Y1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.|||Membrane|||dendritic spine http://togogenome.org/gene/9541:CTSK ^@ http://purl.uniprot.org/uniprot/A0A805RTL9|||http://purl.uniprot.org/uniprot/G8F4A4|||http://purl.uniprot.org/uniprot/P61276 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the peptidase C1 family.|||Cell membrane|||Lysosome|||Secreted|||Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. http://togogenome.org/gene/9541:ACAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X438|||http://purl.uniprot.org/uniprot/A0A2K5X445|||http://purl.uniprot.org/uniprot/A0A2K5X448|||http://purl.uniprot.org/uniprot/A0A7N9IDL1 ^@ Activity Regulation|||Domain|||Function|||Subcellular Location Annotation ^@ Endosome membrane|||GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.|||GTPase-activating protein for the ADP ribosylation factor family.|||PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.|||The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions. http://togogenome.org/gene/9541:TBC1D22B ^@ http://purl.uniprot.org/uniprot/Q95LL3 ^@ Function|||Subunit ^@ Interacts with ACBD3 and ARFGEF1. Interacts with YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ.|||May act as a GTPase-activating protein for Rab family protein(s). http://togogenome.org/gene/9541:SLITRK3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAS2|||http://purl.uniprot.org/uniprot/G7NZH4 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9541:TFRC ^@ http://purl.uniprot.org/uniprot/A0A2K5X958 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.|||Homodimer; disulfide-linked.|||Melanosome|||Membrane|||Stearoylated. http://togogenome.org/gene/9541:ATP6V0A2 ^@ http://purl.uniprot.org/uniprot/Q4R459 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/9541:SLC25A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3Q3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9541:MSL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ18 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:GET3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPH1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.|||Belongs to the arsA ATPase family.|||Cytoplasm|||Endoplasmic reticulum|||Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.|||nucleolus http://togogenome.org/gene/9541:LGI4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W117 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:CCT7 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2V4|||http://purl.uniprot.org/uniprot/A0A2K5X3D4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.|||Cytoplasm|||Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. http://togogenome.org/gene/9541:LOC102142214 ^@ http://purl.uniprot.org/uniprot/I7GHY2 ^@ Function|||Similarity ^@ Belongs to the CMP-Neu5Ac hydroxylase family.|||Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells. http://togogenome.org/gene/9541:ZNF24 ^@ http://purl.uniprot.org/uniprot/A0A2K5URW2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:F11R ^@ http://purl.uniprot.org/uniprot/I7GN79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9541:TES ^@ http://purl.uniprot.org/uniprot/A0A2K5UCY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prickle / espinas / testin family.|||Cytoplasm|||focal adhesion http://togogenome.org/gene/9541:SUSD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7L9|||http://purl.uniprot.org/uniprot/G7NYC0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:MTX2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y183|||http://purl.uniprot.org/uniprot/G7PKW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:SCN8A ^@ http://purl.uniprot.org/uniprot/A0A2K5UI43|||http://purl.uniprot.org/uniprot/A0A2K5UI98|||http://purl.uniprot.org/uniprot/A0A2K5UIB4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9541:RECQL ^@ http://purl.uniprot.org/uniprot/A0A2K5UWF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus http://togogenome.org/gene/9541:LOC102116116 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAP8|||http://purl.uniprot.org/uniprot/A0A2K5WBQ3|||http://purl.uniprot.org/uniprot/Q4R774 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.|||Endoplasmic reticulum membrane|||Membrane|||Plays a role in the export of secreted proteins in the ER. http://togogenome.org/gene/9541:DPYSL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Cytoplasm|||Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.|||growth cone http://togogenome.org/gene/9541:SERPINA7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSY1 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:MFSD11 ^@ http://purl.uniprot.org/uniprot/G7PSW8|||http://purl.uniprot.org/uniprot/Q4R495 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Despite its name it is related to the unc-93 family and not to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9541:PPA1 ^@ http://purl.uniprot.org/uniprot/A0A158SIP7|||http://purl.uniprot.org/uniprot/Q4R543 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9541:IL12A ^@ http://purl.uniprot.org/uniprot/A0A2K5V4L8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-6 superfamily.|||Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.|||Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites.|||Secreted http://togogenome.org/gene/9541:SUMO3 ^@ http://purl.uniprot.org/uniprot/I7G7D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/9541:LIN54 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTF2|||http://purl.uniprot.org/uniprot/A0A2K5UTG1|||http://purl.uniprot.org/uniprot/G8F411 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-54 family.|||Nucleus http://togogenome.org/gene/9541:CDK20 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFY2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:ASPA ^@ http://purl.uniprot.org/uniprot/A0A158SIQ9|||http://purl.uniprot.org/uniprot/A0A2K5X750|||http://purl.uniprot.org/uniprot/Q60HH2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it acts as a scavenger of NAA from body fluids (By similarity).|||Cytoplasm|||Homodimer.|||Nucleus http://togogenome.org/gene/9541:GSTZ1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ65|||http://purl.uniprot.org/uniprot/C0SJM6 ^@ Similarity ^@ Belongs to the GST superfamily. Zeta family. http://togogenome.org/gene/9541:GINS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLH6|||http://purl.uniprot.org/uniprot/G7PH61 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS1/PSF1 family.|||Chromosome|||Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.|||Nucleus|||Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/9541:MUSTN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKZ7|||http://purl.uniprot.org/uniprot/A0A2K5WL93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MUSTANG family.|||Nucleus http://togogenome.org/gene/9541:GRIN3A ^@ http://purl.uniprot.org/uniprot/A0A2K5VQ27|||http://purl.uniprot.org/uniprot/G7PRT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9541:CNIH1 ^@ http://purl.uniprot.org/uniprot/G7PAA6|||http://purl.uniprot.org/uniprot/I7GI01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9541:ICAM4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9H6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/9541:NR0B2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1Q8|||http://purl.uniprot.org/uniprot/G8F2G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:CMTM3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5K3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:WNT10A ^@ http://purl.uniprot.org/uniprot/A0A2K5WE28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:FAM13A ^@ http://purl.uniprot.org/uniprot/A0A2K5V740|||http://purl.uniprot.org/uniprot/A0A2K5V751|||http://purl.uniprot.org/uniprot/A0A2K5V765|||http://purl.uniprot.org/uniprot/A0A2K5V770|||http://purl.uniprot.org/uniprot/A0A2K5V776|||http://purl.uniprot.org/uniprot/G7P5W9 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9541:GNB3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XKZ3|||http://purl.uniprot.org/uniprot/G7PJN5 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9541:PPARGC1B ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ76|||http://purl.uniprot.org/uniprot/A0A2K5VZ80 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PTPRZ1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3R7|||http://purl.uniprot.org/uniprot/A0A2K5V3S3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.|||Membrane http://togogenome.org/gene/9541:UNK ^@ http://purl.uniprot.org/uniprot/A0A2K5W5M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unkempt family.|||Cytoplasm http://togogenome.org/gene/9541:GALM ^@ http://purl.uniprot.org/uniprot/A0A2K5WVT6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the aldose epimerase family.|||Monomer.|||Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. http://togogenome.org/gene/9541:STC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR46 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9541:SLC9C1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5T5|||http://purl.uniprot.org/uniprot/A0A2K5U5T9|||http://purl.uniprot.org/uniprot/A0A7N9DBQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Membrane http://togogenome.org/gene/9541:CPA6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY88 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9541:LONP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNC7|||http://purl.uniprot.org/uniprot/A0A2K5UNG2|||http://purl.uniprot.org/uniprot/A0A2K5UNH6|||http://purl.uniprot.org/uniprot/G7Q128 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.|||Belongs to the peptidase S16 family.|||Interacts with PEX5. Interacts with TYSND1.|||Peroxisome matrix http://togogenome.org/gene/9541:SH3PXD2A ^@ http://purl.uniprot.org/uniprot/A0A2K5VQU9|||http://purl.uniprot.org/uniprot/A0A2K5VQV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3PXD2 family.|||Cytoplasm|||podosome http://togogenome.org/gene/9541:VAMP1 ^@ http://purl.uniprot.org/uniprot/A0A7N9IGI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9541:CCL27 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9R6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:PPAT ^@ http://purl.uniprot.org/uniprot/A0A8J8YHF4|||http://purl.uniprot.org/uniprot/G7P5S2 ^@ Cofactor|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/9541:ELAVL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY08|||http://purl.uniprot.org/uniprot/A0A2K5WY40|||http://purl.uniprot.org/uniprot/A0A2K5WY84 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/9541:TMEM59L ^@ http://purl.uniprot.org/uniprot/A0A2K5VU26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM59 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:JAK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAH4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. http://togogenome.org/gene/9541:TGM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQU1 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9541:EPC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEL3|||http://purl.uniprot.org/uniprot/A0A2K5WEN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/9541:TPMT ^@ http://purl.uniprot.org/uniprot/A0A2K5V568|||http://purl.uniprot.org/uniprot/G7P4I0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9541:OLFM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0W7|||http://purl.uniprot.org/uniprot/A0A2K5U0Y2 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9541:PARP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XL21|||http://purl.uniprot.org/uniprot/G7NTV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARTD/PARP family.|||Chromosome|||Interacts (when auto-poly-ADP-ribosylated) with AIFM1.|||Nucleus|||Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.|||This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. http://togogenome.org/gene/9541:CLDN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKU0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the claudin family.|||Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:TSPOAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V087 ^@ Similarity ^@ Belongs to the RIMBP family. http://togogenome.org/gene/9541:KCTD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KCTD3 family.|||Cell membrane http://togogenome.org/gene/9541:LOC102144954 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/9541:TCEA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VW82|||http://purl.uniprot.org/uniprot/A0A2K5VWA2|||http://purl.uniprot.org/uniprot/A0A2K5VWD3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/9541:TMEM244 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJK9|||http://purl.uniprot.org/uniprot/G7P367 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LHFPL5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCS1|||http://purl.uniprot.org/uniprot/A0A7N9CIQ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PPM1G ^@ http://purl.uniprot.org/uniprot/Q4R4V2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PP2C family.|||Binds 2 magnesium or manganese ions per subunit.|||Cytoplasm|||Interacts with NOL3; may dephosphorylate NOL3.|||Membrane http://togogenome.org/gene/9541:DGCR6L ^@ http://purl.uniprot.org/uniprot/A0A2K5W0W4 ^@ Similarity ^@ Belongs to the gonadal family. http://togogenome.org/gene/9541:FDFT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8Z1|||http://purl.uniprot.org/uniprot/A0A2K5W905|||http://purl.uniprot.org/uniprot/A0A2K5W942|||http://purl.uniprot.org/uniprot/G7PCE4 ^@ Function|||Similarity ^@ Belongs to the phytoene/squalene synthase family.|||Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. http://togogenome.org/gene/9541:RPS6KB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGI0|||http://purl.uniprot.org/uniprot/I7GK15 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9541:ITM2A ^@ http://purl.uniprot.org/uniprot/A0A2K5WKG4|||http://purl.uniprot.org/uniprot/G8F3B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/9541:ATG101 ^@ http://purl.uniprot.org/uniprot/A0A8J8YC85|||http://purl.uniprot.org/uniprot/G7PIC2 ^@ Similarity ^@ Belongs to the ATG101 family. http://togogenome.org/gene/9541:LTBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLJ0|||http://purl.uniprot.org/uniprot/A0A2K5VLJ3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:TMPRSS15 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPZ5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DMBT1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:NQO2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBK1 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/9541:ARID1A ^@ http://purl.uniprot.org/uniprot/A0A2K5V2Y4|||http://purl.uniprot.org/uniprot/A0A2K5V336 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102131904 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8D2|||http://purl.uniprot.org/uniprot/A0A2K5V8D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat fritz family.|||Cell membrane|||Membrane|||cilium axoneme http://togogenome.org/gene/9541:USP39 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUF9|||http://purl.uniprot.org/uniprot/A0A2K5WUR3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NDST2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9541:TMEM214 ^@ http://purl.uniprot.org/uniprot/A0A2K5WR99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TMEM214 family.|||Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.|||Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:RPS4X ^@ http://purl.uniprot.org/uniprot/I7GKK0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/9541:LOC102120517 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQV8|||http://purl.uniprot.org/uniprot/A0A7N9D9L4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/9541:INHBA ^@ http://purl.uniprot.org/uniprot/A0A2K5WK99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9541:MCM4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V919 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9541:SNX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNF5|||http://purl.uniprot.org/uniprot/P0C220 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (By similarity).|||Membrane|||Predominantly forms heterodimers with BAR domain-containing sorting nexins SNX5, SNX6 and SNX32; can self-associate to form homodimers. The heterodimers are proposed to self-assemble into helical arrays on the membrane to stabilize and expand local membrane curvature underlying endosomal tubule formation. Thought to be a component of the originally described retromer complex (also called SNX-BAR retromer) which is a pentamer containing the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS), and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. Interacts with SNX5, SNX6, SNX32, VPS26A, VPS29, VPS35, FNBP1, KALRN, RHOG (GDP-bound form) (By similarity).|||The BAR domain is able to sense membrane curvature upon dimerization. Membrane remodeling seems to implicate insertion of a N-terminal amphipathic helix (AH) in the membrane (By similarity).|||lamellipodium http://togogenome.org/gene/9541:HPX ^@ http://purl.uniprot.org/uniprot/A0A2K5WVL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hemopexin family.|||Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.|||Secreted http://togogenome.org/gene/9541:PRKACG ^@ http://purl.uniprot.org/uniprot/A0A2K5UPW7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/9541:SLC41A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TL38|||http://purl.uniprot.org/uniprot/G7PJD8|||http://purl.uniprot.org/uniprot/Q4R335 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Acts as a plasma-membrane magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9541:RNF175 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7H7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ESRRG ^@ http://purl.uniprot.org/uniprot/A0A2K5UC82|||http://purl.uniprot.org/uniprot/A0A2K5UC83|||http://purl.uniprot.org/uniprot/A0A2K5UCA4|||http://purl.uniprot.org/uniprot/A0A7N9D2N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9541:NCAPG ^@ http://purl.uniprot.org/uniprot/A0A2K5UAT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND3 (condensin subunit 3) family.|||Chromosome http://togogenome.org/gene/9541:MAFA-F ^@ http://purl.uniprot.org/uniprot/A0A2K5TNK5 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9541:GHRHR ^@ http://purl.uniprot.org/uniprot/A0A2K5UWA2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PSMD12 ^@ http://purl.uniprot.org/uniprot/I7GK10 ^@ Similarity ^@ Belongs to the proteasome subunit p55 family. http://togogenome.org/gene/9541:CLK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3C0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:MTOR ^@ http://purl.uniprot.org/uniprot/A0A2K5WYX7 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. http://togogenome.org/gene/9541:BAZ1A ^@ http://purl.uniprot.org/uniprot/A0A2K5VE56|||http://purl.uniprot.org/uniprot/A0A2K5VE62 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NAA60 ^@ http://purl.uniprot.org/uniprot/I7GHY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA60 subfamily.|||Golgi apparatus membrane http://togogenome.org/gene/9541:MAP2K6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZY2|||http://purl.uniprot.org/uniprot/A0A2K5X028|||http://purl.uniprot.org/uniprot/I7GLF8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:LYRM7 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8X1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.|||Belongs to the complex I LYR family.|||Interacts with UQCRFS1.|||Mitochondrion matrix http://togogenome.org/gene/9541:LOC102118834 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||Endoplasmic reticulum http://togogenome.org/gene/9541:NDFIP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3P9 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/9541:MYH10 ^@ http://purl.uniprot.org/uniprot/A0A2K5X383|||http://purl.uniprot.org/uniprot/A0A2K5X3A8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:IRF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXP3|||http://purl.uniprot.org/uniprot/A0A2K5WXX2|||http://purl.uniprot.org/uniprot/G7P6M7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:PTPRB ^@ http://purl.uniprot.org/uniprot/A0A2K5U774|||http://purl.uniprot.org/uniprot/A0A2K5U787|||http://purl.uniprot.org/uniprot/A0A2K5U796 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. http://togogenome.org/gene/9541:NAGLU ^@ http://purl.uniprot.org/uniprot/A0A2K5X2U2 ^@ Subcellular Location Annotation ^@ Lysosome http://togogenome.org/gene/9541:LOC102133200 ^@ http://purl.uniprot.org/uniprot/A0A7N9CF85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:DEGS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:CNTN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCR7|||http://purl.uniprot.org/uniprot/A0A2K5VCW8 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. Contactin family. http://togogenome.org/gene/9541:TCP11L2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXV9 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9541:RFC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPQ0 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/9541:RRAGB ^@ http://purl.uniprot.org/uniprot/A0A2K5VWB6|||http://purl.uniprot.org/uniprot/A0A8J8Y3S3|||http://purl.uniprot.org/uniprot/G7Q2V5|||http://purl.uniprot.org/uniprot/Q4R344 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9541:FUS ^@ http://purl.uniprot.org/uniprot/I7GH09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/9541:LCLAT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W176 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:CELF1 ^@ http://purl.uniprot.org/uniprot/G7PQ93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:SERINC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9541:CNOT9 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLK1|||http://purl.uniprot.org/uniprot/G7PLF9|||http://purl.uniprot.org/uniprot/Q4R347 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CNOT9 family.|||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors. May play a role in cell differentiation.|||Homodimer. Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. Interacts with MYB, ATF2, RARA, RARB, RARG, RXRA, RXRB and RXRG. Identified in a complex with ATF2 bound to target DNA. Interacts with NANOS2. Directly interacts with ZNF335 (By similarity).|||Nucleus|||P-body http://togogenome.org/gene/9541:CDA ^@ http://purl.uniprot.org/uniprot/A0A2K5TSB3|||http://purl.uniprot.org/uniprot/G7NUU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Cytoplasm|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/9541:FAM228A ^@ http://purl.uniprot.org/uniprot/A0A2K5U892 ^@ Similarity ^@ Belongs to the FAM228 family. http://togogenome.org/gene/9541:MTIF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VR16|||http://purl.uniprot.org/uniprot/A0A2K5VRA5 ^@ Similarity ^@ Belongs to the IF-3 family. http://togogenome.org/gene/9541:LOC102137625 ^@ http://purl.uniprot.org/uniprot/G7P2L6|||http://purl.uniprot.org/uniprot/G7P2M7|||http://purl.uniprot.org/uniprot/G7P2P0 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:NPTX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4R8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ZNF496 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2R3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NCK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8W2|||http://purl.uniprot.org/uniprot/A0A8J8YD01|||http://purl.uniprot.org/uniprot/G7PMW0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/9541:SLC25A13 ^@ http://purl.uniprot.org/uniprot/A0A2K5WK98|||http://purl.uniprot.org/uniprot/Q8HXW2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Homodimer (via N-terminus).|||Membrane|||Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (By similarity). Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (By similarity).|||Mitochondrion inner membrane|||The EF-hand 2 domain within the regulatory N-terminal domain binds one calcium in the mitochondrial intermembrane space. Calcium triggers the binding of the regulatory N-terminal domain to the C-terminal domain, opening a vestibule which allows the substrates to be translocated through the carrier domain (By similarity). In the absence of calcium, the linker loop domain may close the vestibule and prevent substrates from entering the carrier domain (By similarity). http://togogenome.org/gene/9541:KCNJ2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEJ8|||http://purl.uniprot.org/uniprot/G7PVA0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.|||Homomultimeric and heteromultimeric association with KCNJ4/Kir2.3. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking.|||Membrane http://togogenome.org/gene/9541:FMNL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U913 ^@ Similarity ^@ Belongs to the formin homology family. http://togogenome.org/gene/9541:LOC102124284 ^@ http://purl.uniprot.org/uniprot/A0A2K5UF72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9541:PFKFB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWX8|||http://purl.uniprot.org/uniprot/A0A2K5VX43|||http://purl.uniprot.org/uniprot/G7NUP7|||http://purl.uniprot.org/uniprot/Q4R3C6 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9541:POMT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/9541:LOC102122868 ^@ http://purl.uniprot.org/uniprot/A0A7N9IBE1 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/9541:FMR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U918|||http://purl.uniprot.org/uniprot/A0A2K5U925|||http://purl.uniprot.org/uniprot/A0A2K5U936 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMR1 family.|||Cell membrane|||Cytoplasmic ribonucleoprotein granule|||Membrane|||Perikaryon|||Presynaptic cell membrane|||Synaptic cell membrane|||axon|||centromere|||dendrite|||dendritic spine|||filopodium tip|||growth cone|||neuron projection|||nucleolus|||perinuclear region|||synaptosome http://togogenome.org/gene/9541:VPS37A ^@ http://purl.uniprot.org/uniprot/A0A2K5W985 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9541:TPM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5USQ3|||http://purl.uniprot.org/uniprot/A0A2K5USX5|||http://purl.uniprot.org/uniprot/A0A2K5UT05|||http://purl.uniprot.org/uniprot/A0A2K5UT06|||http://purl.uniprot.org/uniprot/A0A2K5UT20|||http://purl.uniprot.org/uniprot/A0A2K5UT88|||http://purl.uniprot.org/uniprot/I7GK41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9541:FLI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0V3|||http://purl.uniprot.org/uniprot/A0A2K5X1A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:SCPEP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR63|||http://purl.uniprot.org/uniprot/A0A8J8XDD6|||http://purl.uniprot.org/uniprot/G7PUE0 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9541:PKNOX1 ^@ http://purl.uniprot.org/uniprot/I7GNE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9541:PDE6C ^@ http://purl.uniprot.org/uniprot/A0A2K5TRP4|||http://purl.uniprot.org/uniprot/A0A8J8XK22 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:ARAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5B2|||http://purl.uniprot.org/uniprot/A0A2K5X5U0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:PRRT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4S2|||http://purl.uniprot.org/uniprot/A0A7N9DDH4 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:TAF1D ^@ http://purl.uniprot.org/uniprot/A0A2K5X2F2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.|||Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.|||Nucleus http://togogenome.org/gene/9541:TRPC6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYN3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NDRG4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQV9|||http://purl.uniprot.org/uniprot/A0A2K5VQZ6|||http://purl.uniprot.org/uniprot/A0A2K5VR39|||http://purl.uniprot.org/uniprot/A0A2K5VR54|||http://purl.uniprot.org/uniprot/A0A2K5VR80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NDRG family.|||cytosol http://togogenome.org/gene/9541:TNNT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5R7|||http://purl.uniprot.org/uniprot/A0A2K5U5U3 ^@ Function|||Similarity ^@ Belongs to the troponin T family.|||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/9541:NR4A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:KCNU1 ^@ http://purl.uniprot.org/uniprot/A5LFX5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa5.1/KCNU1 sub-subfamily.|||Cell membrane|||Homotetramer; which constitutes the calcium-activated potassium channel. May interact with LRRC52; this interaction may change some channel gating properties, such as shifting gating to more negative potentials at a given pH.|||Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina (By similarity).|||Testis-specific.|||The C-terminal cytosolic region confers the pH-dependence.|||The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel.|||The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.|||The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium (By similarity). http://togogenome.org/gene/9541:RPS14 ^@ http://purl.uniprot.org/uniprot/A0A2K5X500 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/9541:KCNN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNQ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GTPBP4 ^@ http://purl.uniprot.org/uniprot/Q4R5E5|||http://purl.uniprot.org/uniprot/Q4R901 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/9541:PABPC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQD4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/9541:GNL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TS48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.|||GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.|||nucleolus http://togogenome.org/gene/9541:TRIM55 ^@ http://purl.uniprot.org/uniprot/A0A2K5VC83 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ACTR1A ^@ http://purl.uniprot.org/uniprot/Q4R6J9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin family. ARP1 subfamily.|||Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity).|||Interacts with BCCIP.|||cell cortex|||centrosome|||cytoskeleton http://togogenome.org/gene/9541:EMC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7F9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC1 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:LACC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V206 ^@ Similarity ^@ Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. http://togogenome.org/gene/9541:B4GALT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8H0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9541:DPT ^@ http://purl.uniprot.org/uniprot/A0A2K5VRK7 ^@ Similarity ^@ Belongs to the dermatopontin family. http://togogenome.org/gene/9541:LOC102121356 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5P9 ^@ Function|||Similarity ^@ Belongs to the SSX family.|||Could act as a modulator of transcription. http://togogenome.org/gene/9541:ITGB8 ^@ http://purl.uniprot.org/uniprot/A0A8J8YB37|||http://purl.uniprot.org/uniprot/G7P0S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Membrane http://togogenome.org/gene/9541:FLOT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XNG8|||http://purl.uniprot.org/uniprot/G7P4M4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Cell membrane|||Endosome|||Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.|||May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.|||Membrane|||Membrane raft|||caveola http://togogenome.org/gene/9541:TICAM1 ^@ http://purl.uniprot.org/uniprot/B3Y696 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Homodimer. Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1.|||Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.|||Mitochondrion|||The N-terminal region is essential for activation of the IFNB promoter activity.|||autophagosome|||cytosol http://togogenome.org/gene/9541:MYH13 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUV8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:FGD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTM0 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:L3HYPDH ^@ http://purl.uniprot.org/uniprot/A0A7N9CWN8|||http://purl.uniprot.org/uniprot/A0A8J8XFF6|||http://purl.uniprot.org/uniprot/G7PAE6 ^@ Similarity ^@ Belongs to the proline racemase family. http://togogenome.org/gene/9541:LOC102124877 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYA7|||http://purl.uniprot.org/uniprot/G7P9K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:MFSD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WW70|||http://purl.uniprot.org/uniprot/A0A2K5WWE7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SLC30A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9541:PLG ^@ http://purl.uniprot.org/uniprot/A0A2K5TJJ6 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.|||Secreted http://togogenome.org/gene/9541:FHIP2A ^@ http://purl.uniprot.org/uniprot/A0A2K5TMG4 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/9541:ANKRD13A ^@ http://purl.uniprot.org/uniprot/A0A2K5W2T4 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/9541:UNC119B ^@ http://purl.uniprot.org/uniprot/A0A2K5X4B7 ^@ Similarity ^@ Belongs to the PDE6D/unc-119 family. http://togogenome.org/gene/9541:PARP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARTD/PARP family.|||Nucleus http://togogenome.org/gene/9541:PAQR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X979|||http://purl.uniprot.org/uniprot/A0A2K5X986|||http://purl.uniprot.org/uniprot/Q4R6X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9541:GK ^@ http://purl.uniprot.org/uniprot/A0A2K5TMQ3|||http://purl.uniprot.org/uniprot/A0A2K5TMQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FGGY kinase family.|||Cytoplasm http://togogenome.org/gene/9541:CPB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X065 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9541:SYT17 ^@ http://purl.uniprot.org/uniprot/A0A2K5UV53|||http://purl.uniprot.org/uniprot/G7Q0L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Membrane http://togogenome.org/gene/9541:POU1F1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-1 subfamily.|||Nucleus http://togogenome.org/gene/9541:SLC35F1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VES8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/9541:CCNB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9G9 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9541:ZRANB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTJ9 ^@ Similarity ^@ Belongs to the peptidase C64 family. http://togogenome.org/gene/9541:SNX21 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9541:MPG ^@ http://purl.uniprot.org/uniprot/A0A2K5VR93|||http://purl.uniprot.org/uniprot/Q4R6B1 ^@ Function|||Similarity ^@ Belongs to the DNA glycosylase MPG family.|||Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. http://togogenome.org/gene/9541:NDUFB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5USP8|||http://purl.uniprot.org/uniprot/G7PMD1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB3 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:MDK ^@ http://purl.uniprot.org/uniprot/A0A2K5UAU4 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/9541:SRM ^@ http://purl.uniprot.org/uniprot/A0A2K5WDB1 ^@ Similarity ^@ Belongs to the spermidine/spermine synthase family. http://togogenome.org/gene/9541:ETF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYH8|||http://purl.uniprot.org/uniprot/A0A2K5WYZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm http://togogenome.org/gene/9541:RPS19BP1 ^@ http://purl.uniprot.org/uniprot/G7PFL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AROS family.|||nucleolus http://togogenome.org/gene/9541:PCNX1 ^@ http://purl.uniprot.org/uniprot/A0A7N9IBD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/9541:GKAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYU9|||http://purl.uniprot.org/uniprot/A0A2K5TYX9 ^@ Similarity ^@ Belongs to the GKAP1 family. http://togogenome.org/gene/9541:MGAT2 ^@ http://purl.uniprot.org/uniprot/Q4R3T7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 16 (GT16) protein family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:PRPF18 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8J0|||http://purl.uniprot.org/uniprot/A0A8J8XTV6|||http://purl.uniprot.org/uniprot/G7PEE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/9541:PPP2CA ^@ http://purl.uniprot.org/uniprot/Q4R5N5 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/9541:XPOT ^@ http://purl.uniprot.org/uniprot/A0A2K5V425|||http://purl.uniprot.org/uniprot/A0A2K5V442 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus|||tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. http://togogenome.org/gene/9541:CXCR4 ^@ http://purl.uniprot.org/uniprot/Q28474 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell junction|||Cell membrane|||Early endosome|||Late endosome|||Lysosome|||Monomer. Can form homodimers. Interacts with CD164. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARR3; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts with RNF113A; the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and subsequent degradation. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with DBN1; this interaction is enhanced by antigenic stimulation. Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8.|||O- and N-glycosylated. N-glycosylation can mask coreceptor function. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity.|||Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-324 and Ser-325 leads to recruitment of ITCH, ubiquitination and protein degradation.|||Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity).|||Sulfation is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization.|||Ubiquitinated after ligand binding, leading to its degradation. Ubiquitinated by ITCH at the cell membrane on agonist stimulation. The ubiquitin-dependent mechanism, endosomal sorting complex required for transport (ESCRT), then targets CXCR4 for lysosomal degradation. This process is dependent also on prior Ser-/Thr-phosphorylation in the C-terminal of CXCR4. Also binding of ARRB1 to STAM negatively regulates CXCR4 sorting to lysosomes though modulating ubiquitination of SFR5S. http://togogenome.org/gene/9541:THBS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WN13|||http://purl.uniprot.org/uniprot/A0A2K5WN65|||http://purl.uniprot.org/uniprot/A0A2K5WN70 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:TRIM17 ^@ http://purl.uniprot.org/uniprot/A0A2K5TV96|||http://purl.uniprot.org/uniprot/A0A7N9D4A6|||http://purl.uniprot.org/uniprot/G8F2Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Nucleus http://togogenome.org/gene/9541:NT5DC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKB7 ^@ Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family. http://togogenome.org/gene/9541:PDE6H ^@ http://purl.uniprot.org/uniprot/A0A8J8YH66|||http://purl.uniprot.org/uniprot/G7PJY4 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/9541:EIF5 ^@ http://purl.uniprot.org/uniprot/A0A2K5V638|||http://purl.uniprot.org/uniprot/G7PBP4 ^@ Function|||Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). http://togogenome.org/gene/9541:TDRD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UE00|||http://purl.uniprot.org/uniprot/G8F2W0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SMN family.|||Cajal body|||Cytoplasm|||Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. http://togogenome.org/gene/9541:TAAR5 ^@ http://purl.uniprot.org/uniprot/A0A2K5URA9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:INSL6 ^@ http://purl.uniprot.org/uniprot/A0A8J8YHS2|||http://purl.uniprot.org/uniprot/G7PSF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9541:MMS19 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MET18/MMS19 family.|||Component of the CIA complex.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.|||Nucleus|||spindle http://togogenome.org/gene/9541:DERL2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XH18|||http://purl.uniprot.org/uniprot/G7PTB3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:THNSL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFB8 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/9541:HADHA ^@ http://purl.uniprot.org/uniprot/A0A2K5WXU8 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9541:NLN ^@ http://purl.uniprot.org/uniprot/A0A2K5UX94|||http://purl.uniprot.org/uniprot/A0A2K5UXD0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/9541:HCRTR1 ^@ http://purl.uniprot.org/uniprot/G7NWX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:MST1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCZ4|||http://purl.uniprot.org/uniprot/A2V9Z1 ^@ Caution|||Similarity ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:IL12RB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9541:FUCA1 ^@ http://purl.uniprot.org/uniprot/I7GKJ7 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/9541:MS4A15 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMT7 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9541:CSNK1A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU67|||http://purl.uniprot.org/uniprot/A0A7N9CID8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:DAG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM36 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.|||Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.|||cytoskeleton|||extracellular space|||nucleoplasm|||sarcolemma http://togogenome.org/gene/9541:MLLT11 ^@ http://purl.uniprot.org/uniprot/Q4R5A9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC101866572 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUS6|||http://purl.uniprot.org/uniprot/G8F5P9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.|||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:DAD1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJ59|||http://purl.uniprot.org/uniprot/G7P9T9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9541:EEF1G ^@ http://purl.uniprot.org/uniprot/Q4R7H5 ^@ Function|||Subunit ^@ EF-1 is composed of four subunits: alpha, beta, delta, and gamma.|||Probably plays a role in anchoring the complex to other cellular components. http://togogenome.org/gene/9541:DTYMK ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ98 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/9541:TECRL ^@ http://purl.uniprot.org/uniprot/A0A2K5WN19|||http://purl.uniprot.org/uniprot/A0A2K5WN39|||http://purl.uniprot.org/uniprot/A0A8J8Y262|||http://purl.uniprot.org/uniprot/G7P5R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane http://togogenome.org/gene/9541:TSPAN5 ^@ http://purl.uniprot.org/uniprot/A0A7N9DCS4|||http://purl.uniprot.org/uniprot/A0A8J8Y6H9|||http://purl.uniprot.org/uniprot/G7P5Y5|||http://purl.uniprot.org/uniprot/I7GE81 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PCNX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WH32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/9541:TAF9B ^@ http://purl.uniprot.org/uniprot/I7GJX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/9541:PLRG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWH6 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/9541:ATP5PO ^@ http://purl.uniprot.org/uniprot/A0A2K5TRX2|||http://purl.uniprot.org/uniprot/A0A7N9IET0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:TLR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFD8|||http://purl.uniprot.org/uniprot/Q95M53 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Toll-like receptor family.|||Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).|||Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.|||Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.|||Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.|||In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.|||Interacts with LY96, TLR1 and TLR6 (via extracellular domain). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36. Binds MYD88 (via TIR domain). Interacts with TICAM1. Interacts with CNPY3. Interacts with ATG16L1. Interacts with PPP1R11. Interacts with TICAM2. Interacts with TIRAP (By similarity).|||Membrane|||Membrane raft|||The ATG16L1-binding motif mediates interaction with ATG16L1.|||Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2.|||phagosome membrane http://togogenome.org/gene/9541:NIPSNAP3B ^@ http://purl.uniprot.org/uniprot/A0A2K5V6K5 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/9541:MFGE8 ^@ http://purl.uniprot.org/uniprot/A0A7N9CEV6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PISD ^@ http://purl.uniprot.org/uniprot/A0A2K5U7R0|||http://purl.uniprot.org/uniprot/A0A2K5U7S4|||http://purl.uniprot.org/uniprot/A0A2K5U7S5|||http://purl.uniprot.org/uniprot/A0A7N9CLL7 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:BCAS2 ^@ http://purl.uniprot.org/uniprot/I7GHG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPF27 family.|||Nucleus http://togogenome.org/gene/9541:CPLX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9541:GABRG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQ17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:GCLM ^@ http://purl.uniprot.org/uniprot/G7NTP5 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.|||Heterodimer of a catalytic heavy chain and a regulatory light chain. http://togogenome.org/gene/9541:CCR5 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5W1 ^@ Similarity|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with GRK2. Interacts with ARRB1 and ARRB2. Interacts with CNIH4. Interacts with S100A4; this interaction stimulates T-lymphocyte chemotaxis. http://togogenome.org/gene/9541:ELMO2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCF6|||http://purl.uniprot.org/uniprot/A0A8J8Y2M8|||http://purl.uniprot.org/uniprot/G7PG35 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/9541:DMRTC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUF2|||http://purl.uniprot.org/uniprot/A0A2K5VUM8|||http://purl.uniprot.org/uniprot/G7PXP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/9541:MOB3A ^@ http://purl.uniprot.org/uniprot/A0A2K5W9A1|||http://purl.uniprot.org/uniprot/G7PYC3 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9541:HOXA7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UC88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9541:TGFB1I1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWY0|||http://purl.uniprot.org/uniprot/A0A2K5WX04 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paxillin family.|||Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways.|||Nucleus matrix|||The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.|||cytoskeleton|||focal adhesion http://togogenome.org/gene/9541:FMO1 ^@ http://purl.uniprot.org/uniprot/A0A023JCL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9541:YIPF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMJ1|||http://purl.uniprot.org/uniprot/A0A8J8YRQ4|||http://purl.uniprot.org/uniprot/G7NVQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Late endosome membrane|||Membrane|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:FAM98C ^@ http://purl.uniprot.org/uniprot/A0A2K5UY19 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/9541:ZNF283 ^@ http://purl.uniprot.org/uniprot/Q95K52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:TPRA1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XCA6|||http://purl.uniprot.org/uniprot/G7PJ00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0359 family.|||Membrane http://togogenome.org/gene/9541:RHOT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGS5|||http://purl.uniprot.org/uniprot/A0A2K5WGS8|||http://purl.uniprot.org/uniprot/A0A2K5WGT8|||http://purl.uniprot.org/uniprot/A0A2K5WGU1|||http://purl.uniprot.org/uniprot/A0A7N9CW05|||http://purl.uniprot.org/uniprot/A0A8J8Y5N8|||http://purl.uniprot.org/uniprot/G7PU10 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial Rho GTPase family.|||Membrane|||Mitochondrial GTPase involved in mitochondrial trafficking.|||Mitochondrion outer membrane http://togogenome.org/gene/9541:STIM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2B5|||http://purl.uniprot.org/uniprot/A0A2K5X2B6|||http://purl.uniprot.org/uniprot/A0A8J8Y995|||http://purl.uniprot.org/uniprot/G7PQZ7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:LOC102119082 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted|||VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. http://togogenome.org/gene/9541:E2F2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9541:SLC45A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TL58 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:BMP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YC70|||http://purl.uniprot.org/uniprot/G7PGY1 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9541:LOC102130270 ^@ http://purl.uniprot.org/uniprot/A0A2K5U723 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neugrin family.|||Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.|||Mitochondrion membrane|||Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system. http://togogenome.org/gene/9541:MED29 ^@ http://purl.uniprot.org/uniprot/A0A2K5VL72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 29 family.|||Nucleus http://togogenome.org/gene/9541:SRSF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWC7|||http://purl.uniprot.org/uniprot/A0A8J8Y0L8|||http://purl.uniprot.org/uniprot/G7NWV7 ^@ Similarity ^@ Belongs to the splicing factor SR family. http://togogenome.org/gene/9541:SCG5 ^@ http://purl.uniprot.org/uniprot/Q2PFP9|||http://purl.uniprot.org/uniprot/Q4R570 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.|||Belongs to the 7B2 family.|||Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.|||Secreted http://togogenome.org/gene/9541:MYB ^@ http://purl.uniprot.org/uniprot/A0A2K5TSE4|||http://purl.uniprot.org/uniprot/A0A2K5TSE8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:QRFPR ^@ http://purl.uniprot.org/uniprot/A0A2K5X3X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9541:CNR1 ^@ http://purl.uniprot.org/uniprot/G7P3K6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Signaling typically involves reduction in cyclic AMP.|||Interacts (via C-terminus) with CNRIP1.|||Membrane|||Mitochondrion outer membrane|||Presynapse|||Synapse|||axon http://togogenome.org/gene/9541:CDKN1A ^@ http://purl.uniprot.org/uniprot/A0A8J8XAP2|||http://purl.uniprot.org/uniprot/G7P3C1 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/9541:ADCK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDQ8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/9541:ZNF174 ^@ http://purl.uniprot.org/uniprot/A0A2K5UK08|||http://purl.uniprot.org/uniprot/A0A2K5UK10|||http://purl.uniprot.org/uniprot/G7Q0C6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:KRT23 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMA8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:NEUROD1 ^@ http://purl.uniprot.org/uniprot/G7PKY7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:AGA ^@ http://purl.uniprot.org/uniprot/Q4R6C4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Ntn-hydrolase family.|||Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity.|||Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.|||Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.|||Lysosome|||N-glycosylated. http://togogenome.org/gene/9541:RPE65 ^@ http://purl.uniprot.org/uniprot/G7NWZ1 ^@ Similarity ^@ Belongs to the carotenoid oxygenase family. http://togogenome.org/gene/9541:PLA2G5 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7P1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9541:PAMR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4L4|||http://purl.uniprot.org/uniprot/A0A2K5U4P7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:NIBAN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCH1 ^@ Similarity ^@ Belongs to the Niban family. http://togogenome.org/gene/9541:EGFR ^@ http://purl.uniprot.org/uniprot/A0A2K5WK39|||http://purl.uniprot.org/uniprot/A0A2K5WKC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9541:DPF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZJ8 ^@ Similarity ^@ Belongs to the requiem/DPF family. http://togogenome.org/gene/9541:MT1E ^@ http://purl.uniprot.org/uniprot/G7Q165 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9541:CNOT6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XS73|||http://purl.uniprot.org/uniprot/G7P737 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCR4/nocturin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:DMRT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/9541:NRP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5B8|||http://purl.uniprot.org/uniprot/A0A2K5V5E7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:SLC25A28 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:GCAT ^@ http://purl.uniprot.org/uniprot/I7GL53 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9541:C13H2orf49 ^@ http://purl.uniprot.org/uniprot/A0A2K5W831 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ashwin family.|||Nucleus http://togogenome.org/gene/9541:KAT8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQ49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9541:PSMC1 ^@ http://purl.uniprot.org/uniprot/Q4R5I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:EIF2D ^@ http://purl.uniprot.org/uniprot/A0A2K5U4Z6|||http://purl.uniprot.org/uniprot/A0A7N9CWY5|||http://purl.uniprot.org/uniprot/G7NVB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF2D family.|||Cytoplasm|||Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. http://togogenome.org/gene/9541:PFKL ^@ http://purl.uniprot.org/uniprot/A0A2K5W4P0 ^@ Similarity ^@ Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily. http://togogenome.org/gene/9541:ZNF614 ^@ http://purl.uniprot.org/uniprot/Q95K49 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:SLC2A8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSR9 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9541:UBE4B ^@ http://purl.uniprot.org/uniprot/A0A2K5W1A0|||http://purl.uniprot.org/uniprot/A0A2K5W1H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm http://togogenome.org/gene/9541:STAC ^@ http://purl.uniprot.org/uniprot/A0A7N9CCB6 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9541:MTX1 ^@ http://purl.uniprot.org/uniprot/Q4R3I0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metaxin family.|||Interacts with MTX2/metaxin-2 (By similarity). Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13 (By similarity). This complex was also known under the names MINOS or MitOS complex (By similarity). The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (By similarity). The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex (By similarity). Interacts with ARMC1 (By similarity).|||Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity).|||Mitochondrion outer membrane|||Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. http://togogenome.org/gene/9541:ENTPD7 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1J8 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9541:ZDHHC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZX1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:LOC102121015 ^@ http://purl.uniprot.org/uniprot/A0A7N9CR08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:MARS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UET5|||http://purl.uniprot.org/uniprot/A0A2K5UET9 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:TIMELESS ^@ http://purl.uniprot.org/uniprot/A0A2K5UPM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the timeless family.|||Nucleus http://togogenome.org/gene/9541:CASP8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHA1|||http://purl.uniprot.org/uniprot/A0A2K5WHB0|||http://purl.uniprot.org/uniprot/I7GIH6 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9541:PFKM ^@ http://purl.uniprot.org/uniprot/A0A2K5WK70|||http://purl.uniprot.org/uniprot/A0A7N9CDZ6|||http://purl.uniprot.org/uniprot/G7PHQ1 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homo- and heterotetramers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:TSPAN14 ^@ http://purl.uniprot.org/uniprot/A0A2K5X647|||http://purl.uniprot.org/uniprot/G7PEX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:MTFMT ^@ http://purl.uniprot.org/uniprot/A0A2K5X8R2 ^@ Similarity ^@ Belongs to the Fmt family. http://togogenome.org/gene/9541:PTHLH ^@ http://purl.uniprot.org/uniprot/A0A2K5W832 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the parathyroid hormone family.|||Cytoplasm|||Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.|||Nucleus|||Osteostatin is a potent inhibitor of osteoclastic bone resorption.|||PTHrP interacts with PTH1R (via N-terminal extracellular domain).|||Secreted|||There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions. http://togogenome.org/gene/9541:CDKL3 ^@ http://purl.uniprot.org/uniprot/Q4R8T9 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||Cytoplasm|||The [NKR]KIAxRE motif seems to be a cyclin-binding region. http://togogenome.org/gene/9541:BPNT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WD40|||http://purl.uniprot.org/uniprot/A0A2K5WD73 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9541:PLPPR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TN07|||http://purl.uniprot.org/uniprot/I7G910 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Cell membrane|||May play a role in neurite outgrowth and neurogenesis.|||Membrane|||neuron projection http://togogenome.org/gene/9541:TDGF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U096 ^@ Caution|||Similarity ^@ Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:REEP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0Z8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PTBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5V2|||http://purl.uniprot.org/uniprot/A0A2K5U5X7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PRKACA ^@ http://purl.uniprot.org/uniprot/A0A2K5UC31 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/9541:ADAD2 ^@ http://purl.uniprot.org/uniprot/Q95JV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ADAD family.|||Cytoplasm|||Nucleus|||Required for male fertility and normal male germ cell differentiation. http://togogenome.org/gene/9541:TOMM22 ^@ http://purl.uniprot.org/uniprot/Q4R3C7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tom22 family.|||Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity).|||Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with PPP2R2B and TOMM40 (By similarity).|||Mitochondrion outer membrane|||The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins. Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex (By similarity). http://togogenome.org/gene/9541:COG4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3G2|||http://purl.uniprot.org/uniprot/G7Q1L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG4 family.|||Golgi apparatus membrane http://togogenome.org/gene/9541:UBL3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZA0|||http://purl.uniprot.org/uniprot/G7PVY1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:TMEM35B ^@ http://purl.uniprot.org/uniprot/A0A2K5WKY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/9541:ESRRB ^@ http://purl.uniprot.org/uniprot/A0A2K5UA66|||http://purl.uniprot.org/uniprot/A0A7N9IF67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9541:CANT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTK9|||http://purl.uniprot.org/uniprot/G7PT20 ^@ Similarity ^@ Belongs to the apyrase family. http://togogenome.org/gene/9541:MAPT ^@ http://purl.uniprot.org/uniprot/A0A2K5WB83|||http://purl.uniprot.org/uniprot/A0A2K5WB98|||http://purl.uniprot.org/uniprot/A0A2K5WBC5|||http://purl.uniprot.org/uniprot/A0A2K5WBE1|||http://purl.uniprot.org/uniprot/A0A2K5WBE7|||http://purl.uniprot.org/uniprot/A0A2K5WBI2 ^@ Subcellular Location Annotation ^@ Membrane|||axon|||cytoskeleton|||cytosol http://togogenome.org/gene/9541:ATAD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U312|||http://purl.uniprot.org/uniprot/A0A8J8XCG1 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9541:CNOT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X010 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT2/3/5 family.|||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.|||Nucleus|||P-body http://togogenome.org/gene/9541:CBX5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBV7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SCG3 ^@ http://purl.uniprot.org/uniprot/G7PBH1|||http://purl.uniprot.org/uniprot/I7G9U8 ^@ Subcellular Location Annotation ^@ Membrane|||Secreted|||secretory vesicle membrane http://togogenome.org/gene/9541:GLS ^@ http://purl.uniprot.org/uniprot/A0A2K5VL44|||http://purl.uniprot.org/uniprot/A0A2K5VL60 ^@ Similarity ^@ Belongs to the glutaminase family. http://togogenome.org/gene/9541:LOC102134747 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQW0 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9541:SRD5A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDR0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).|||Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. http://togogenome.org/gene/9541:CASQ2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0H8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/9541:EML3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1R1 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:CHRNB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:CPD ^@ http://purl.uniprot.org/uniprot/A0A2K5VXK0 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9541:OTUD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3G4 ^@ Similarity ^@ Belongs to the peptidase C85 family. http://togogenome.org/gene/9541:RPF2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CQC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/9541:SLC45A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:C4H6orf89 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCP8|||http://purl.uniprot.org/uniprot/A0A7N9CFN8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:SLC6A16 ^@ http://purl.uniprot.org/uniprot/G7PY67 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102128529 ^@ http://purl.uniprot.org/uniprot/A0A8J8YPI1|||http://purl.uniprot.org/uniprot/G7P1L2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9541:GSK3A ^@ http://purl.uniprot.org/uniprot/A0A2K5WS68 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/9541:RAP1GDS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQI0|||http://purl.uniprot.org/uniprot/A0A2K5TQJ3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Mitochondrion|||cytosol http://togogenome.org/gene/9541:MRPL37 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSP6 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9541:LOC102133455 ^@ http://purl.uniprot.org/uniprot/A0A7N9CRV9 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9541:TMEM9B ^@ http://purl.uniprot.org/uniprot/A0A2K5VQ21|||http://purl.uniprot.org/uniprot/A0A7N9CG06|||http://purl.uniprot.org/uniprot/A0A7N9D7R0 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/9541:LOC102131860 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:FGF5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WF43|||http://purl.uniprot.org/uniprot/A0A8J8Y8K5|||http://purl.uniprot.org/uniprot/G7P530 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heparin-binding growth factors family.|||Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.|||Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.|||Secreted http://togogenome.org/gene/9541:TNFSF8 ^@ http://purl.uniprot.org/uniprot/A0A7N9CVX7 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9541:SLC25A21 ^@ http://purl.uniprot.org/uniprot/A0A8J8YS57|||http://purl.uniprot.org/uniprot/G7PA42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:GALT ^@ http://purl.uniprot.org/uniprot/A0A8J8Y7V6|||http://purl.uniprot.org/uniprot/G7PS28 ^@ Cofactor|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/9541:MYMK ^@ http://purl.uniprot.org/uniprot/A0A2K5TN97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PHKG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDF4|||http://purl.uniprot.org/uniprot/A0A7N9CTB8 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/9541:CAMK2A ^@ http://purl.uniprot.org/uniprot/A0A2K5VDI3|||http://purl.uniprot.org/uniprot/A0A2K5VDJ3 ^@ PTM|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.|||Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9541:CRX ^@ http://purl.uniprot.org/uniprot/A0A2K5X2T7|||http://purl.uniprot.org/uniprot/G7PY08 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LYN ^@ http://purl.uniprot.org/uniprot/A0A2K5VF55|||http://purl.uniprot.org/uniprot/G7PBV3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9541:SEC13 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5M8|||http://purl.uniprot.org/uniprot/A0A8J8XDY5|||http://purl.uniprot.org/uniprot/G7NYT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Lysosome membrane|||nuclear pore complex http://togogenome.org/gene/9541:LOC101866788 ^@ http://purl.uniprot.org/uniprot/I7G3L0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRF-binding protein family.|||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|||Secreted http://togogenome.org/gene/9541:PRDX5 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6Z8|||http://purl.uniprot.org/uniprot/I7GHU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxiredoxin family. Prx5 subfamily.|||Peroxisome matrix|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. http://togogenome.org/gene/9541:CSNK2A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TL09 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:MOGAT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6Y1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:STAC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQY8 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9541:LOC102131808 ^@ http://purl.uniprot.org/uniprot/A0A2K5UK22|||http://purl.uniprot.org/uniprot/A0A2K5UK35|||http://purl.uniprot.org/uniprot/A0A8J8YQ24|||http://purl.uniprot.org/uniprot/G7PP05 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/9541:LOC107126435 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y118|||http://purl.uniprot.org/uniprot/G7Q164 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9541:PIN1 ^@ http://purl.uniprot.org/uniprot/Q4R383 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with STIL (By similarity). Interacts with KIF20B. Interacts with NEK6. Interacts (via WW domain) with PRKX. Interacts with BTK. Interacts (via PpiC domain) with DAPK1. Interacts with the phosphorylated form of RAF1. Interacts (via WW domain) with ATCAY; upon NGF stimulation. Interacts with PML (isoform PML-4). Interacts with BCL6. Interacts with FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation. Directly interacts with RBBP8/CtIP; this interaction depends upon RBBP8 phosphorylation. Interacts (via WW domain) with IRAK3/IRAK-M (when phosphorylated at 'Ser-110') in response to IL33-mediated (but not TLR4 ligand LPS) dendritic cell stimulation (By similarity).|||Nucleus|||Nucleus speckle|||Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes. Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner. Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN. May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells.|||Phosphorylation at Ser-71 by DAPK1 results in inhibition of its catalytic activity, nuclear localization, and its ability to induce centrosome amplification, chromosome instability and cell transformation (By similarity). Ser-71 is dephosphorylated upon IL33-stimulation of dendritic cells (By similarity).|||The WW domain is required for the interaction with STIL and KIF20B. http://togogenome.org/gene/9541:USP30 ^@ http://purl.uniprot.org/uniprot/A0A8J8XM81|||http://purl.uniprot.org/uniprot/G7PI60 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9541:TMEM14C ^@ http://purl.uniprot.org/uniprot/A0A2K5VEW3 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9541:ANP32B ^@ http://purl.uniprot.org/uniprot/A0A2K5V4N6 ^@ Similarity ^@ Belongs to the ANP32 family. http://togogenome.org/gene/9541:PTPRT ^@ http://purl.uniprot.org/uniprot/A0A2K5U0K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.|||Membrane http://togogenome.org/gene/9541:DOLK ^@ http://purl.uniprot.org/uniprot/I7GJA0 ^@ Similarity ^@ Belongs to the polyprenol kinase family. http://togogenome.org/gene/9541:LOC102122019 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTD8 ^@ Function|||Similarity ^@ Belongs to the SSX family.|||Could act as a modulator of transcription. http://togogenome.org/gene/9541:HCN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UY80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel HCN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TK2 ^@ http://purl.uniprot.org/uniprot/Q9N0C5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DCK/DGK family.|||Homodimer.|||Mitochondrion|||Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix (By similarity). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK (By similarity). http://togogenome.org/gene/9541:LOC102127157 ^@ http://purl.uniprot.org/uniprot/G8F5F7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SMAD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:MCCC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7P9 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/9541:ARHGDIG ^@ http://purl.uniprot.org/uniprot/A0A2K5WMG2 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/9541:IZUMO4 ^@ http://purl.uniprot.org/uniprot/Q4R6V5 ^@ Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Izumo family.|||Izumo is the name of a Japanese shrine to marriage.|||Secreted http://togogenome.org/gene/9541:SLC39A11 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU21 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TAS2R10 ^@ http://purl.uniprot.org/uniprot/A0A7N9CV58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9541:SERP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VW72 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAMP4 family.|||Endoplasmic reticulum membrane|||May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.|||Membrane http://togogenome.org/gene/9541:AGL ^@ http://purl.uniprot.org/uniprot/A0A2K5VHN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycogen debranching enzyme family.|||Cytoplasm|||Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. http://togogenome.org/gene/9541:KCND2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.|||Cell junction|||Cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite|||dendritic spine http://togogenome.org/gene/9541:EFNB3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CSQ9 ^@ Caution|||Similarity ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:FBXO25 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTQ8|||http://purl.uniprot.org/uniprot/A0A8J8Y0Q7|||http://purl.uniprot.org/uniprot/G7PCB4|||http://purl.uniprot.org/uniprot/Q4R372 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Nucleus|||Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO25, SKP1, CUL1 and RBX1. Interacts directly with SKP1 and CUL1. Interacts (via C-terminus) with beta-actin (via N-terminus).|||Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).|||The F-box is necessary for the interaction with SKP1. http://togogenome.org/gene/9541:TRIM67 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAT7 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:ELOVL5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLG5|||http://purl.uniprot.org/uniprot/Q4R516 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Belongs to the ELO family. ELOVL5 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity). In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid (By similarity).|||Endoplasmic reticulum membrane|||Membrane|||dendrite http://togogenome.org/gene/9541:PKN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WD50 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. http://togogenome.org/gene/9541:NOP10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UB95 ^@ Similarity ^@ Belongs to the NOP10 family. http://togogenome.org/gene/9541:DENND6A ^@ http://purl.uniprot.org/uniprot/A0A2K5VAS5|||http://purl.uniprot.org/uniprot/A0A7N9CTT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND6 family.|||Endosome|||Recycling endosome http://togogenome.org/gene/9541:SOD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHX3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/9541:PNN ^@ http://purl.uniprot.org/uniprot/A0A2K5WBP0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pinin family.|||Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.|||Nucleus speckle|||desmosome http://togogenome.org/gene/9541:MRPL49 ^@ http://purl.uniprot.org/uniprot/A0A158SIR6|||http://purl.uniprot.org/uniprot/Q4R5K7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrion-specific ribosomal protein mL49 family.|||Interacts with OXA1L.|||Mitochondrion http://togogenome.org/gene/9541:DOLPP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ40|||http://purl.uniprot.org/uniprot/G7PRE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dolichyldiphosphatase family.|||Endoplasmic reticulum membrane|||Membrane|||Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. http://togogenome.org/gene/9541:ACAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYS8 ^@ Activity Regulation|||Domain|||Function|||Subcellular Location Annotation ^@ Endosome membrane|||GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.|||GTPase-activating protein for the ADP ribosylation factor family.|||PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.|||The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions. http://togogenome.org/gene/9541:FAM53B ^@ http://purl.uniprot.org/uniprot/A0A2K5UNE9|||http://purl.uniprot.org/uniprot/G7PEB2 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/9541:CA8 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8M9|||http://purl.uniprot.org/uniprot/G7PBW7 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/9541:CARMIL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNM1|||http://purl.uniprot.org/uniprot/G7P4K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CARMIL family.|||Cytoplasm http://togogenome.org/gene/9541:LRP12 ^@ http://purl.uniprot.org/uniprot/A0A2K5UC79|||http://purl.uniprot.org/uniprot/A0A2K5UC80 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:HSF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5URJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9541:DARS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7F9 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. http://togogenome.org/gene/9541:KLC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQ22 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/9541:HYLS1 ^@ http://purl.uniprot.org/uniprot/G7PPM8|||http://purl.uniprot.org/uniprot/Q4R2Y2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HYLS1 family.|||Cytoplasm|||Plays a role in ciliogenesis.|||centriole|||cilium http://togogenome.org/gene/9541:KCTD11 ^@ http://purl.uniprot.org/uniprot/A0A2K5UD36 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:CYP27A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPY6|||http://purl.uniprot.org/uniprot/B8K1T2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:MYH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VV03 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:TBPL1 ^@ http://purl.uniprot.org/uniprot/Q4R848 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBP family.|||Binds TFIIA and TFIIB.|||Cytoplasm|||Nucleus|||Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box (By similarity). http://togogenome.org/gene/9541:LOC102145217 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9B8 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9541:REEP5 ^@ http://purl.uniprot.org/uniprot/I7GJW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/9541:FERMT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WND2|||http://purl.uniprot.org/uniprot/A0A2K5WNF5|||http://purl.uniprot.org/uniprot/A0A2K5WNM0|||http://purl.uniprot.org/uniprot/A0A7N9CWN5|||http://purl.uniprot.org/uniprot/G7PAA0 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/9541:HINT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRF4 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/9541:CD5L ^@ http://purl.uniprot.org/uniprot/A0A2K5W535 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:OAS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UA31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-5A synthase family.|||Cytoplasm http://togogenome.org/gene/9541:CPT1C ^@ http://purl.uniprot.org/uniprot/A0A2K5X2P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:TMEM106B ^@ http://purl.uniprot.org/uniprot/A0A2K5W4F7|||http://purl.uniprot.org/uniprot/G7P199|||http://purl.uniprot.org/uniprot/I7GBY0 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9541:SLC37A4 ^@ http://purl.uniprot.org/uniprot/I7G4C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/9541:ABCC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:DIAPH3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4R2 ^@ Similarity ^@ Belongs to the formin homology family. Diaphanous subfamily. http://togogenome.org/gene/9541:RND3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQU8|||http://purl.uniprot.org/uniprot/G7PKK2 ^@ Function ^@ Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. http://togogenome.org/gene/9541:PPM1B ^@ http://purl.uniprot.org/uniprot/A0A2K5X995|||http://purl.uniprot.org/uniprot/G7PM43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/9541:BZW1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UI69|||http://purl.uniprot.org/uniprot/A0A2K5UI79 ^@ Similarity ^@ Belongs to the BZW family. http://togogenome.org/gene/9541:RPL19 ^@ http://purl.uniprot.org/uniprot/G7NZM6|||http://purl.uniprot.org/uniprot/I7GIH9|||http://purl.uniprot.org/uniprot/Q8HXN9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Citrullinated by PADI4.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm http://togogenome.org/gene/9541:HOXB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9541:LPAR3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YRY6|||http://purl.uniprot.org/uniprot/G7NTK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:HNRNPA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAW3|||http://purl.uniprot.org/uniprot/A0A7N9CZ09 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:RPL3L ^@ http://purl.uniprot.org/uniprot/A0A2K5WXI5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/9541:RBM15 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN70 ^@ Similarity ^@ Belongs to the RRM Spen family. http://togogenome.org/gene/9541:UBE2L3 ^@ http://purl.uniprot.org/uniprot/I7GH11 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:ARL6IP5 ^@ http://purl.uniprot.org/uniprot/Q4R4R4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRA1 family.|||Cell membrane|||Cytoplasm|||Endoplasmic reticulum membrane|||Homodimer. Heterodimer with ARL6IP1. Forms multimers. Interacts with ARL6. Interacts with prenylated RAB1A and RAB3A. Interacts with SLC1A1/EAAC1. Interacts with RTN2 (via first transmembrane domain). Does not interact with VAMP1, VAMP2 or VAMP3.|||Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum.|||cytoskeleton http://togogenome.org/gene/9541:TNF ^@ http://purl.uniprot.org/uniprot/P79337 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity).|||Homotrimer. Interacts with SPPL2B (By similarity).|||Membrane|||O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.|||Secreted|||The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.|||The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).|||The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity).|||The soluble form is demyristoylated by SIRT6, promoting its secretion. http://togogenome.org/gene/9541:LOC102128765 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDW5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:PTCD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS39 family.|||Mitochondrion http://togogenome.org/gene/9541:FUT11 ^@ http://purl.uniprot.org/uniprot/A0A2K5WG99|||http://purl.uniprot.org/uniprot/A0A2K5WGG2|||http://purl.uniprot.org/uniprot/I7G3R0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. http://togogenome.org/gene/9541:NPTX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKM1|||http://purl.uniprot.org/uniprot/A0A7N9ICP5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:FOXP3 ^@ http://purl.uniprot.org/uniprot/Q6U8D7 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Acetylation on lysine residues stabilizes FOXP3 and promotes differentiation of T-cells into induced regulatory T-cells (iTregs) associated with suppressive functions. Acetylation is mediated by a coordinated action of KAT5 and EP300/p300 acetyltransferases: EP300/p300 is required to enhance KAT5 autoacetylation, promoting acetylation of FOXP3 by KAT5. Deacetylated by SIRT1.|||Cytoplasm|||Homodimer. Dimerization is essential for its transcriptional regulator activity. Interacts with IKZF3. Interacts (via LXXLL motif) with RORA (via AF-2 motif). Interacts with HDAC9 in the absence of T-cell stimulation. Interacts with PPP1CA, PPP1CB, PPP1CG, KAT5, HDAC7, HSPA8, USP7, STUB1, HSPA1A/B, RUNX1, RUNX2, RUNX3, RELA, NFATC2, IKFZ4 and RORC.|||Nucleus|||Phosphorylation at Ser-418 regulates its transcriptional repressor activity and consequently, regulatory T-cells (Treg) suppressive function. Phosphorylation by CDK2 negatively regulates its transcriptional activity and protein stability.|||Polyubiquitinated, leading to its proteasomal degradation in regulatory T-cells (Treg) which is mediated by STUB1 in a HSPA1A/B-dependent manner. Deubiquitinated by USP7 leading to increase in protein stability.|||The fork-head DNA-binding domain is essential for its dimerization and interaction with NFATC2.|||Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2. Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7. Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1. Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development. Inhibits the transcriptional activator activity of RORA (By similarity). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity).|||Undergoes proteolytic cleavage in activated regulatory T-cells (Treg), and can be cleaved at either the N- or C-terminal site, or at both sites. http://togogenome.org/gene/9541:GSTO2 ^@ http://purl.uniprot.org/uniprot/A0A023JBX8|||http://purl.uniprot.org/uniprot/A0A2K5TM32|||http://purl.uniprot.org/uniprot/A0A8J8Y1F3|||http://purl.uniprot.org/uniprot/G7PDX3 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/9541:TMEM200A ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2X5|||http://purl.uniprot.org/uniprot/G7P364 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/9541:LOC102136892 ^@ http://purl.uniprot.org/uniprot/A0A8J8YF44|||http://purl.uniprot.org/uniprot/G7P6V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:NRDC ^@ http://purl.uniprot.org/uniprot/A0A2K5U2Z7|||http://purl.uniprot.org/uniprot/A0A7N9DC69|||http://purl.uniprot.org/uniprot/G8F3N6 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9541:TUBD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTU1|||http://purl.uniprot.org/uniprot/Q4R7T7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a positive regulator of hedgehog signaling and regulates ciliary function.|||Belongs to the tubulin family.|||Cytoplasm|||Found in a complex with TEDC1, TEDC2, TUBE1 and TUBD1.|||Nucleus|||centriole|||cilium http://togogenome.org/gene/9541:CMTM2 ^@ http://purl.uniprot.org/uniprot/Q4R7K4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NR1I3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPJ4|||http://purl.uniprot.org/uniprot/A0A2K5VPJ6|||http://purl.uniprot.org/uniprot/B6E442 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:CAPZA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBE7|||http://purl.uniprot.org/uniprot/A0A7N9CHX3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/9541:IL17F ^@ http://purl.uniprot.org/uniprot/A0A8J8XMV3|||http://purl.uniprot.org/uniprot/G7P4V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9541:LPGAT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:MRPS17 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMY2|||http://purl.uniprot.org/uniprot/A0A7N9CHQ5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/9541:PDGFRB ^@ http://purl.uniprot.org/uniprot/A0A2K5TUS0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Cytoplasmic vesicle|||Interacts with homodimeric PDGFB and PDGFD, and with heterodimers formed by PDGFA and PDGFB.|||Lysosome lumen|||Membrane|||Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.|||Vesicle http://togogenome.org/gene/9541:LOC102136403 ^@ http://purl.uniprot.org/uniprot/A0A2K5VU94 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COA3 family.|||Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.|||Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.|||Membrane|||Required for assembly of cytochrome c oxidase (complex IV). http://togogenome.org/gene/9541:LMX1A ^@ http://purl.uniprot.org/uniprot/A0A8J8YD50|||http://purl.uniprot.org/uniprot/G7NU26 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102131547 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIB8|||http://purl.uniprot.org/uniprot/G7NVK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:DAO ^@ http://purl.uniprot.org/uniprot/A0A2K5UAL0|||http://purl.uniprot.org/uniprot/A0A7N9I9P5|||http://purl.uniprot.org/uniprot/A2V9Y8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAMOX/DASOX family.|||Homodimer.|||Peroxisome|||Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids (By similarity). http://togogenome.org/gene/9541:MAPK10 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUM6|||http://purl.uniprot.org/uniprot/A0A2K5TUX5|||http://purl.uniprot.org/uniprot/A0A2K5TVI5|||http://purl.uniprot.org/uniprot/A0A2K5TVL4|||http://purl.uniprot.org/uniprot/G7P5U7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/9541:WNT9A ^@ http://purl.uniprot.org/uniprot/I7G6H3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:CCDC86 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2W7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:WDR83OS ^@ http://purl.uniprot.org/uniprot/A0A2K5X8Q3 ^@ Similarity ^@ Belongs to the Asterix family. http://togogenome.org/gene/9541:MIX23 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULX4|||http://purl.uniprot.org/uniprot/A0A2K5ULX6 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/9541:CDH26 ^@ http://purl.uniprot.org/uniprot/A0A2K5WI33 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:GALNT11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:RASSF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3H2 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:OIP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWZ8 ^@ Function|||Subcellular Location Annotation ^@ Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.|||centromere http://togogenome.org/gene/9541:SCGB1D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZJ9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:MYO1B ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ33|||http://purl.uniprot.org/uniprot/A0A2K5VJ37|||http://purl.uniprot.org/uniprot/A0A8J8XWY6|||http://purl.uniprot.org/uniprot/G7PL24 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:ARHGDIA ^@ http://purl.uniprot.org/uniprot/G7PT55|||http://purl.uniprot.org/uniprot/Q4R4J0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Rho GDI family.|||Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.|||Cytoplasm|||Monomer (By similarity). Interacts with FER (By similarity). Interacts with PLXNB3 (By similarity). Forms a heterodimer with RAC1. Interacts with RHOA, the affinity is increased by three orders of magnitude when RHOA is prenylated. Interacts with PSMD10; the interaction increases ARHGDIA association with RHOA, leading to ARHGDIA-mediated inactivation of RHOA and ROCK and prolonged AKT activation. Interacts with KANK2; the interaction is direct and may regulate the interaction of ARHGDIA with RHOA, RAC1 and CDC42. Interacts with RHOC. Interacts with CDC42 (By similarity). Interacts with NGFR (via death domain); NGFR binding decreases the affinity for RHOA (By similarity). http://togogenome.org/gene/9541:HMGN5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9541:FCER1G ^@ http://purl.uniprot.org/uniprot/Q8SPW1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation.|||Belongs to the CD3Z/FCER1G family.|||Cell membrane|||IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Associates with FCGR1A; forms a functional signaling complex (By similarity). The signaling subunit of immunoglobulin gamma (IgG) Fc receptor complex. As a homodimer or a heterodimer of CD247 and FCER1G, associates with the ligand binding subunit FCGR3A to form a functional receptor complex (By similarity). Associates with CLEC6A. Interacts with CLEC4E. Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with CSF2RB and recruits SYK in response to IL3 stimulation; this interaction is direct (By similarity). Interacts with CD300LH; the interaction may be indirect. Interacts with CD300LD (By similarity). Interacts with TARM1 (By similarity). http://togogenome.org/gene/9541:PRKAR1A ^@ http://purl.uniprot.org/uniprot/A0A2K5UUV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LRRTM3 ^@ http://purl.uniprot.org/uniprot/Q9BGP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRTM family.|||Cell membrane|||May play a role in the development and maintenance of the vertebrate nervous system. Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity).|||Postsynaptic cell membrane http://togogenome.org/gene/9541:MX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLE8|||http://purl.uniprot.org/uniprot/K4JB78 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9541:ADCY4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5W7|||http://purl.uniprot.org/uniprot/G7P9Z3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9541:SSTR4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:WEE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPE1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.|||Binds 2 magnesium ions per subunit.|||Nucleus http://togogenome.org/gene/9541:ZNF574 ^@ http://purl.uniprot.org/uniprot/Q4R8S8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:SLC23A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEK7|||http://purl.uniprot.org/uniprot/A0A2K5VEL0|||http://purl.uniprot.org/uniprot/G7PK36 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:KPNA3 ^@ http://purl.uniprot.org/uniprot/I7GIR2 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9541:CPEB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W828|||http://purl.uniprot.org/uniprot/A0A2K5W834|||http://purl.uniprot.org/uniprot/A0A8J8XCI2|||http://purl.uniprot.org/uniprot/G7P6X8 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9541:PGK2 ^@ http://purl.uniprot.org/uniprot/Q4R3K4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Essential for sperm motility and male fertility but is not required for the completion of spermatogenesis.|||Monomer. http://togogenome.org/gene/9541:CYP11B2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPL9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:DLC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXN9|||http://purl.uniprot.org/uniprot/A0A2K5VXP6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.|||Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration.|||Membrane|||focal adhesion http://togogenome.org/gene/9541:CXCR6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6U6|||http://purl.uniprot.org/uniprot/A0A7N9DCG8|||http://purl.uniprot.org/uniprot/Q9BDS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1. http://togogenome.org/gene/9541:ROCK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cell membrane|||Membrane|||centrosome http://togogenome.org/gene/9541:DIPK1B ^@ http://purl.uniprot.org/uniprot/A0A2K5U3Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:PLA2G4A ^@ http://purl.uniprot.org/uniprot/A0A2K5VI33 ^@ Domain ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding. http://togogenome.org/gene/9541:GPCPD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5R1|||http://purl.uniprot.org/uniprot/G7PGX3 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9541:CYP3A4 ^@ http://purl.uniprot.org/uniprot/P33268 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||By polychlorinated biphenyl (PCB).|||Catalyzes nifedipine and nilvadipine oxidations.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:CAMK2N1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAMK2N family.|||Synapse http://togogenome.org/gene/9541:SLC27A5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UM39 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9541:TMEM199 ^@ http://purl.uniprot.org/uniprot/I7GNH2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:LOC101865522 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZZ1|||http://purl.uniprot.org/uniprot/G7Q0V3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. http://togogenome.org/gene/9541:PPP1R2C ^@ http://purl.uniprot.org/uniprot/Q4R615 ^@ Function|||Similarity ^@ Belongs to the protein phosphatase inhibitor 2 family.|||Functions as a protein phosphatase inhibitor. It inhibits activity of the catalytic subunit of PP1 and weakly inhibits the activity of myosin-associated phosphates (By similarity). http://togogenome.org/gene/9541:TMEM106A ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ61|||http://purl.uniprot.org/uniprot/A0A8J8Y5F0|||http://purl.uniprot.org/uniprot/G7PUX6 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9541:NTS ^@ http://purl.uniprot.org/uniprot/A0A8J8XFV0|||http://purl.uniprot.org/uniprot/G7PIL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurotensin family.|||Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/9541:KCNK16 ^@ http://purl.uniprot.org/uniprot/A0A2K5W673|||http://purl.uniprot.org/uniprot/A0A2K5W678 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9541:NCSTN ^@ http://purl.uniprot.org/uniprot/Q4R7R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nicastrin family.|||Membrane http://togogenome.org/gene/9541:UHRF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7E0|||http://purl.uniprot.org/uniprot/A0A7N9DBW3|||http://purl.uniprot.org/uniprot/A0A7N9IGB3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:KCNT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5USG8|||http://purl.uniprot.org/uniprot/A0A2K5USL3|||http://purl.uniprot.org/uniprot/A0A2K5USM4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:HSPB7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UE10|||http://purl.uniprot.org/uniprot/A0A7N9IBP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/9541:LRFN2 ^@ http://purl.uniprot.org/uniprot/Q9BE71 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LRFN family.|||Forms heteromeric complexes with LRFN1, LRFN3, LRFN4 and LRFN5. Can form homomeric complexes, but not across cell junctions. Interacts with 2 NMDA receptor subunits GRIN1 and GRIN2A. Interacts with DLG1, DLG2, DLG3 and DLG4 (By similarity).|||Glycosylated.|||Membrane|||Postsynaptic cell membrane|||Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery (By similarity).|||Synapse|||The PDZ-binding motif is required for cell surface expression, neurite outgrowth promotion and interaction with DLG1, DLG3 and DLG4. http://togogenome.org/gene/9541:TSPAN31 ^@ http://purl.uniprot.org/uniprot/A0A2K5UP83|||http://purl.uniprot.org/uniprot/A0A8J8Y0F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:TMBIM6 ^@ http://purl.uniprot.org/uniprot/I7GKH2|||http://purl.uniprot.org/uniprot/Q4R5G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9541:CASP3 ^@ http://purl.uniprot.org/uniprot/Q2PFV2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C14A family.|||Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.|||Cytoplasm|||Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce.|||Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes (By similarity). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction. Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (By similarity). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (By similarity).|||S-nitrosylated on its catalytic site cysteine in unstimulated cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol. http://togogenome.org/gene/9541:LOC102122677 ^@ http://purl.uniprot.org/uniprot/A0A7N9D9Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:EFNA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZR7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PPIC ^@ http://purl.uniprot.org/uniprot/A0A2K5V6K3 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9541:WNT5A ^@ http://purl.uniprot.org/uniprot/A0A2K5WEH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:PGM2L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UV16|||http://purl.uniprot.org/uniprot/A0A7N9CAA4 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9541:GAST ^@ http://purl.uniprot.org/uniprot/A0A2K5V138 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.|||Secreted http://togogenome.org/gene/9541:SEPHS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWZ1 ^@ Function ^@ Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/9541:LIN9 ^@ http://purl.uniprot.org/uniprot/Q4R8N2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition (By similarity).|||Belongs to the lin-9 family.|||Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RB1 (By similarity).|||nucleoplasm http://togogenome.org/gene/9541:CLDN2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YF99|||http://purl.uniprot.org/uniprot/G7Q3E1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:MSN ^@ http://purl.uniprot.org/uniprot/A0A2K5WCE4 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9541:CRYGB ^@ http://purl.uniprot.org/uniprot/A0A2K5VQC7 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9541:LOC102139144 ^@ http://purl.uniprot.org/uniprot/G7P2Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:EXOC7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAR9|||http://purl.uniprot.org/uniprot/A0A2K5UAV8|||http://purl.uniprot.org/uniprot/A0A2K5UB16|||http://purl.uniprot.org/uniprot/A0A2K5UB38 ^@ Function|||Similarity ^@ Belongs to the EXO70 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9541:ADSS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5A6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. http://togogenome.org/gene/9541:LOC102116561 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZP4|||http://purl.uniprot.org/uniprot/A0A7N9IEQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVBP family.|||Secreted|||cytoskeleton http://togogenome.org/gene/9541:TUBB3 ^@ http://purl.uniprot.org/uniprot/Q60HC2 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with UNC5C (via cytoplasmic domain); this interaction is decreased by NTN1/Netrin-1 (By similarity). Interacts with NLRP5/MATER at cytoskeleton microtubules (By similarity). Interacts with DPYSL5 (By similarity).|||Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.|||Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (By similarity).|||Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility.|||The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation.|||The highly acidic C-terminal region may bind cations such as calcium.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB3 plays a critical role in proper axon guidance and maintenance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord.|||cytoskeleton|||filopodium|||growth cone|||lamellipodium http://togogenome.org/gene/9541:CACNB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNZ2|||http://purl.uniprot.org/uniprot/A0A2K5VP04|||http://purl.uniprot.org/uniprot/A0A2K5VP40|||http://purl.uniprot.org/uniprot/A0A2K5VP41|||http://purl.uniprot.org/uniprot/A0A2K5VP77 ^@ Similarity ^@ Belongs to the calcium channel beta subunit family. http://togogenome.org/gene/9541:WSCD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJL6 ^@ Similarity ^@ Belongs to the WSCD family. http://togogenome.org/gene/9541:SIVA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBT5 ^@ Function|||PTM|||Subcellular Location Annotation ^@ Cytoplasm|||Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.|||Nucleus|||Phosphorylated by ABL2/ARG in response to oxidative stress. http://togogenome.org/gene/9541:FXYD6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U219|||http://purl.uniprot.org/uniprot/G7PP24 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/9541:LOC102141063 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Secreted|||Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. http://togogenome.org/gene/9541:CKMT2 ^@ http://purl.uniprot.org/uniprot/G7P7V7 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9541:KDELR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAM1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PENK ^@ http://purl.uniprot.org/uniprot/A0A2K5UXG1|||http://purl.uniprot.org/uniprot/G7PBW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Increases glutamate release in the striatum and decreases GABA concentration in the striatum.|||Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Secreted|||chromaffin granule lumen http://togogenome.org/gene/9541:HDAC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8T1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.|||Nucleus http://togogenome.org/gene/9541:CAPN1 ^@ http://purl.uniprot.org/uniprot/Q9GLG2 ^@ Activity Regulation|||Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Activated by micromolar concentrations of calcium and inhibited by calpastatin.|||Belongs to the peptidase C2 family.|||Binds 4 Ca(2+) ions.|||Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1. Cleaves and activates caspase-7 (CASP7).|||Cell membrane|||Cytoplasm|||Forms a heterodimer with a small (regulatory) subunit (CAPNS1).|||Ubiquitous.|||Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms (By similarity). http://togogenome.org/gene/9541:MPDU1 ^@ http://purl.uniprot.org/uniprot/G7PTI3|||http://purl.uniprot.org/uniprot/I7GJN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPDU1 (TC 2.A.43.3) family.|||Membrane|||Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors. http://togogenome.org/gene/9541:TPPP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5USV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TPPP family.|||cytoskeleton http://togogenome.org/gene/9541:RIPK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.|||Cytoplasm|||Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.|||Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. http://togogenome.org/gene/9541:LOC102127751 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYJ1|||http://purl.uniprot.org/uniprot/A0A2K5VYL2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b560 family.|||Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). http://togogenome.org/gene/9541:AMPD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSN3|||http://purl.uniprot.org/uniprot/A0A2K5TSN5|||http://purl.uniprot.org/uniprot/A0A2K5TSQ8 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Homotetramer. http://togogenome.org/gene/9541:RNF111 ^@ http://purl.uniprot.org/uniprot/A0A8J8XF14|||http://purl.uniprot.org/uniprot/G7PBK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Arkadia family.|||PML body http://togogenome.org/gene/9541:TEKT3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YPQ6|||http://purl.uniprot.org/uniprot/G7PTQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9541:LOC102124095 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQY2|||http://purl.uniprot.org/uniprot/A0A2K5WKG3 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:RNMT ^@ http://purl.uniprot.org/uniprot/Q4R7K1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.|||Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.|||Interacts with importin alpha, leading to stimulate both RNA-binding and methyltransferase activity. Interaction with importin alpha and beta is required for its nuclear localization, importin beta dissociating in response to RanGTP, allowing RNMT-importin alpha to bind RNA substrates. Interacts with elongating form of polymerase II and RNGTT. Interacts with RAMAC, this interaction significantly enhances RNA-binding and cap methyltransferase activity.|||Methyltransferase activity is activated by RAMAC.|||Nucleus http://togogenome.org/gene/9541:NOXA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5URL5 ^@ Similarity ^@ Belongs to the NCF2/NOXA1 family. http://togogenome.org/gene/9541:NONO ^@ http://purl.uniprot.org/uniprot/A0A2K5WWT3|||http://purl.uniprot.org/uniprot/G7Q300 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9541:CCL26 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWH1|||http://purl.uniprot.org/uniprot/G8F636 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:SYT14 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3B7|||http://purl.uniprot.org/uniprot/A0A2K5W3C8|||http://purl.uniprot.org/uniprot/A0A2K5W3H5 ^@ Similarity ^@ Belongs to the synaptotagmin family. http://togogenome.org/gene/9541:GRK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYY3|||http://purl.uniprot.org/uniprot/G7PVS6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9541:MRM2 ^@ http://purl.uniprot.org/uniprot/I7GEP9 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. http://togogenome.org/gene/9541:RAB4A ^@ http://purl.uniprot.org/uniprot/A0A2K5WPN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. http://togogenome.org/gene/9541:FAM151B ^@ http://purl.uniprot.org/uniprot/A0A2K5W0F3 ^@ Similarity ^@ Belongs to the FAM151 family. http://togogenome.org/gene/9541:LOC101866861 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TRSPAP family.|||Cytoplasm|||Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.|||Nucleus http://togogenome.org/gene/9541:CEP20 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8V3|||http://purl.uniprot.org/uniprot/A0A2K5X8V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP43 family.|||centriole|||cilium basal body http://togogenome.org/gene/9541:PI4K2A ^@ http://purl.uniprot.org/uniprot/A0A2K5W8J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.|||Membrane http://togogenome.org/gene/9541:LOC102114898 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102124195 ^@ http://purl.uniprot.org/uniprot/A0A2K5X511 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9541:EFNA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTZ0|||http://purl.uniprot.org/uniprot/G7NV61 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:SFTPC ^@ http://purl.uniprot.org/uniprot/A0A2K5W7G9 ^@ Function|||Subcellular Location Annotation ^@ Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.|||surface film http://togogenome.org/gene/9541:TUBB2A ^@ http://purl.uniprot.org/uniprot/I7GJK7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9541:TFIP11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFC3|||http://purl.uniprot.org/uniprot/G7PHF9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFP11/STIP family.|||Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.|||Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.|||Nucleus http://togogenome.org/gene/9541:SLC25A39 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKD4|||http://purl.uniprot.org/uniprot/A0A2K5TKF9|||http://purl.uniprot.org/uniprot/A0A2K5TKG3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:PNPLA6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTH0 ^@ Similarity ^@ Belongs to the NTE family. http://togogenome.org/gene/9541:SGCZ ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9541:ADGRA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V551 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PRKAB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0G4 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/9541:ZSCAN9 ^@ http://purl.uniprot.org/uniprot/A0A2K5W564|||http://purl.uniprot.org/uniprot/A0A2K5W588 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TTC27 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYH1 ^@ Similarity ^@ Belongs to the TTC27 family. http://togogenome.org/gene/9541:B3GNT5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UET4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:LOC101867366 ^@ http://purl.uniprot.org/uniprot/Q4R7F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCHP family.|||cytoskeleton http://togogenome.org/gene/9541:EDARADD ^@ http://purl.uniprot.org/uniprot/Q95LN5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B (By similarity).|||Cytoplasm|||Self-associates and binds to EDAR, TRAF1, TRAF2 and TRAF3. http://togogenome.org/gene/9541:METTL2A ^@ http://purl.uniprot.org/uniprot/I7GA20 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9541:TRIM13 ^@ http://purl.uniprot.org/uniprot/I7GIW4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102121909 ^@ http://purl.uniprot.org/uniprot/A0A2K5TP27 ^@ Subunit ^@ Interacts with hair keratins. http://togogenome.org/gene/9541:HMGN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4W9|||http://purl.uniprot.org/uniprot/A0A2K5V4Y1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function.|||Nucleus http://togogenome.org/gene/9541:EIF1B ^@ http://purl.uniprot.org/uniprot/G7NYI7|||http://purl.uniprot.org/uniprot/Q4R4X9 ^@ Function|||Similarity ^@ Belongs to the SUI1 family.|||Probably involved in translation. http://togogenome.org/gene/9541:E2F7 ^@ http://purl.uniprot.org/uniprot/A0A2K5X799 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9541:BBOX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJL2|||http://purl.uniprot.org/uniprot/I7GLK1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-BBH/TMLD family.|||Catalyzes the formation of L-carnitine from gamma-butyrobetaine.|||Cytoplasm http://togogenome.org/gene/9541:UBA7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEG2 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9541:PIP4P1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2D5|||http://purl.uniprot.org/uniprot/Q4R6W2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (By similarity). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (By similarity). May play a role in the regulation of cellular cholesterol metabolism (By similarity).|||Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).|||Cell membrane|||Endosome membrane|||Interacts (via transmembrane domain) with ATP6V0D1 (By similarity). Interacts with LAMTOR1, RRAGA and RRAGC (By similarity).|||Late endosome membrane|||Lysosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/9541:SYNE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUY3|||http://purl.uniprot.org/uniprot/A0A2K5WV05 ^@ Similarity ^@ Belongs to the nesprin family. http://togogenome.org/gene/9541:ATRNL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WB84 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LDHA ^@ http://purl.uniprot.org/uniprot/Q4R7X1 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9541:ZNF14 ^@ http://purl.uniprot.org/uniprot/Q4R4C7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:ECSIT ^@ http://purl.uniprot.org/uniprot/Q4R5Q4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity).|||As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the ECSIT family.|||Cytoplasm|||Interacts with MAP3K1, SMAD4 and TRAF6. Interacts with SMAD1 only after BMP4-treatment (By similarity). Part of the mitochondrial complex I assembly/MCIA complex that comprises at least the core subunits TMEM126B, NDUFAF1, ECSIT and ACAD9 and complement subunits such as COA1 and TMEM186. Interacts with NDUFAF1. Interacts with ACAD9 (By similarity). Interacts with TRIM59 (By similarity). Interacts with TMEM70 and TMEM242 (By similarity).|||Mitochondrion|||Nucleus http://togogenome.org/gene/9541:PSEN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR49 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||The PAL motif is required for normal active site conformation. http://togogenome.org/gene/9541:FGF19 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDB5 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:GLYAT ^@ http://purl.uniprot.org/uniprot/A0A2K5UI23|||http://purl.uniprot.org/uniprot/G7PS78 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/9541:PSMG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PSMG1 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.|||Cytoplasm|||Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.|||Forms a heterodimer with psmg2. http://togogenome.org/gene/9541:TAF12 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVK9|||http://purl.uniprot.org/uniprot/A0A7N9DG10|||http://purl.uniprot.org/uniprot/G8F4R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF12 family.|||Nucleus http://togogenome.org/gene/9541:PSMB10 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2Y2|||http://purl.uniprot.org/uniprot/A0A7N9CQ77 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:YPEL5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XEH2|||http://purl.uniprot.org/uniprot/G7PLY8|||http://purl.uniprot.org/uniprot/I7G2D8 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9541:MRPS24 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Mitochondrion http://togogenome.org/gene/9541:FOLR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U044 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9541:LIMK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W114|||http://purl.uniprot.org/uniprot/A0A2K5W121 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/9541:MPV17L2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/9541:RHBDF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Endoplasmic reticulum membrane|||Membrane|||Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. http://togogenome.org/gene/9541:NECAP1 ^@ http://purl.uniprot.org/uniprot/I7G7L4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9541:IFNB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9541:RNF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4W8 ^@ Subcellular Location Annotation ^@ Chromosome|||Cytoplasm http://togogenome.org/gene/9541:NEIL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0A2 ^@ Similarity ^@ Belongs to the FPG family. http://togogenome.org/gene/9541:ELP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7E7|||http://purl.uniprot.org/uniprot/A0A2K5U7H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:CORT ^@ http://purl.uniprot.org/uniprot/A0A2K5V9I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/9541:DHRS7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUY5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:SLC35B3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9541:SLC7A13 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLP0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:WNT9B ^@ http://purl.uniprot.org/uniprot/A0A7N9DG84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:PMP22 ^@ http://purl.uniprot.org/uniprot/A0A2K5VV49 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Might be involved in growth regulation, and in myelinization in the peripheral nervous system. http://togogenome.org/gene/9541:UGT8 ^@ http://purl.uniprot.org/uniprot/A0A8J8XN91|||http://purl.uniprot.org/uniprot/G7P652 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9541:APOBEC4 ^@ http://purl.uniprot.org/uniprot/Q8WP22 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Putative C to U editing enzyme whose physiological substrate is not yet known. http://togogenome.org/gene/9541:SPC24 ^@ http://purl.uniprot.org/uniprot/A0A2K5URI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPC24 family.|||Nucleus|||kinetochore http://togogenome.org/gene/9541:C19H19orf71 ^@ http://purl.uniprot.org/uniprot/A5LFW8 ^@ Function|||Subcellular Location Annotation ^@ Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Located at the center of the tektin bundle where may function to recruit tektins or stabilize the bundle.|||cilium axoneme http://togogenome.org/gene/9541:TEKT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9541:MAPK9 ^@ http://purl.uniprot.org/uniprot/A0A2K5W148|||http://purl.uniprot.org/uniprot/A0A2K5W155|||http://purl.uniprot.org/uniprot/A0A2K5W1A8|||http://purl.uniprot.org/uniprot/A0A2K5W1C8|||http://purl.uniprot.org/uniprot/A0A2K5W1I5|||http://purl.uniprot.org/uniprot/G7P735 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/9541:STX3 ^@ http://purl.uniprot.org/uniprot/A0A7N9C6S4|||http://purl.uniprot.org/uniprot/A0A7N9C9E6 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9541:YPEL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W800|||http://purl.uniprot.org/uniprot/G7Q0W2 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9541:LOC102132235 ^@ http://purl.uniprot.org/uniprot/G7PVY6|||http://purl.uniprot.org/uniprot/Q2PG08 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MAPEG family.|||Endoplasmic reticulum membrane|||Homotrimer. Interacts with LTC4S and ALOX5 (By similarity).|||Membrane|||Nucleus membrane|||Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity).|||The C-terminal part after residue 140 is mostly disordered. http://togogenome.org/gene/9541:TMEM230 ^@ http://purl.uniprot.org/uniprot/A0A7N9D152|||http://purl.uniprot.org/uniprot/I7GDG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Early endosome|||Endosome|||Involved in trafficking and recycling of synaptic vesicles.|||Late endosome|||Membrane|||Recycling endosome|||Vesicle|||autophagosome|||synaptic vesicle|||trans-Golgi network http://togogenome.org/gene/9541:HOXC12 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYK9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ANKRD13B ^@ http://purl.uniprot.org/uniprot/A0A2K5TXT8 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/9541:OLFM3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XLY7|||http://purl.uniprot.org/uniprot/G7NV38|||http://purl.uniprot.org/uniprot/I7GIX6 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9541:LOC101867505 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3W6|||http://purl.uniprot.org/uniprot/I7G6V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Cytoplasm http://togogenome.org/gene/9541:DCBLD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUZ0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:CCR1 ^@ http://purl.uniprot.org/uniprot/G7NY36|||http://purl.uniprot.org/uniprot/Q2Y2P0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with CREB3.|||Membrane|||Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation (By similarity). http://togogenome.org/gene/9541:ADRM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADRM1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:CTNNB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5B7|||http://purl.uniprot.org/uniprot/A0A2K5U5C8|||http://purl.uniprot.org/uniprot/Q4R3D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||adherens junction http://togogenome.org/gene/9541:CHN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZQ2 ^@ Function ^@ GTPase-activating protein for p21-rac. http://togogenome.org/gene/9541:MFAP5 ^@ http://purl.uniprot.org/uniprot/A0A7N9ICY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||extracellular matrix http://togogenome.org/gene/9541:PPP5C ^@ http://purl.uniprot.org/uniprot/I7GMI2 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. http://togogenome.org/gene/9541:LOC102138308 ^@ http://purl.uniprot.org/uniprot/A0A2K5UID5|||http://purl.uniprot.org/uniprot/G8F2Y9 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:SEC22C ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5P5|||http://purl.uniprot.org/uniprot/G7NY71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/9541:LOC101865946 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXI2 ^@ Subcellular Location Annotation ^@ Cell junction|||Golgi stack|||Synapse|||cytoskeleton http://togogenome.org/gene/9541:IPO11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VA86|||http://purl.uniprot.org/uniprot/A0A2K5VA88 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:LOC102121016 ^@ http://purl.uniprot.org/uniprot/A0A2K5VE07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:DUSP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9541:MYO5C ^@ http://purl.uniprot.org/uniprot/A0A2K5U327|||http://purl.uniprot.org/uniprot/A0A2K5U346 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:SLX9 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1A3|||http://purl.uniprot.org/uniprot/Q4R7C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLX9 family.|||nucleolus http://togogenome.org/gene/9541:KHDRBS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U823|||http://purl.uniprot.org/uniprot/Q4R3J1 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/9541:RB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UC26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the retinoblastoma protein (RB) family.|||Nucleus http://togogenome.org/gene/9541:ITPR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAE8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the InsP3 receptor family.|||Endoplasmic reticulum membrane|||Homotetramer.|||Membrane|||Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.|||The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. http://togogenome.org/gene/9541:PLP1 ^@ http://purl.uniprot.org/uniprot/I7G2D4|||http://purl.uniprot.org/uniprot/Q4R4L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9541:ADRA2B ^@ http://purl.uniprot.org/uniprot/A0A2K5TP48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.|||Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:MED31 ^@ http://purl.uniprot.org/uniprot/A0A8J8YGZ2|||http://purl.uniprot.org/uniprot/G7PTE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 31 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9541:HS3ST5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VC73 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9541:NSUN6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUN4 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9541:CPNE9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBD9|||http://purl.uniprot.org/uniprot/A0A2K5VBE5 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9541:ROM1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y7A2|||http://purl.uniprot.org/uniprot/G7PPU1 ^@ Similarity ^@ Belongs to the PRPH2/ROM1 family. http://togogenome.org/gene/9541:ARHGEF9 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8X3|||http://purl.uniprot.org/uniprot/A0A2K5U923 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.|||Cytoplasm|||Interacts with GPHN.|||Postsynaptic density http://togogenome.org/gene/9541:KIF21A ^@ http://purl.uniprot.org/uniprot/A0A2K5UIJ7|||http://purl.uniprot.org/uniprot/A0A2K5UIY9|||http://purl.uniprot.org/uniprot/A0A2K5UJ12 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||cytoskeleton http://togogenome.org/gene/9541:GAB1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XW79|||http://purl.uniprot.org/uniprot/G7P6C4 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/9541:RAB18 ^@ http://purl.uniprot.org/uniprot/A0A2K5UD45|||http://purl.uniprot.org/uniprot/I7GNY8 ^@ Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Lipid droplet http://togogenome.org/gene/9541:FOXJ2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAZ9|||http://purl.uniprot.org/uniprot/A0A2K5VB14 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:EPS8L3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUW4 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/9541:DCBLD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V661 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:OPA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJA2|||http://purl.uniprot.org/uniprot/A0A2K5TJA3|||http://purl.uniprot.org/uniprot/A0A2K5TJB5 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9541:RRP7A ^@ http://purl.uniprot.org/uniprot/Q4R3Q9 ^@ Similarity ^@ Belongs to the RRP7 family. http://togogenome.org/gene/9541:LOC102144707 ^@ http://purl.uniprot.org/uniprot/A0A2K5VS08|||http://purl.uniprot.org/uniprot/A0A2K5VS16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:TAS1R1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSK3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:THOC7 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3K4|||http://purl.uniprot.org/uniprot/A0A2K5V3K9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC7 family.|||Nucleus|||Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. http://togogenome.org/gene/9541:BMP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V439 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer.|||Secreted http://togogenome.org/gene/9541:CYP4F22 ^@ http://purl.uniprot.org/uniprot/A0A2K5VE55 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:TSSC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X637|||http://purl.uniprot.org/uniprot/A0A7N9ICA6 ^@ Similarity ^@ Belongs to the TSSC4 family. http://togogenome.org/gene/9541:VPS33B ^@ http://purl.uniprot.org/uniprot/A0A2K5V6T3|||http://purl.uniprot.org/uniprot/A0A2K5V6X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||clathrin-coated vesicle http://togogenome.org/gene/9541:NDUFS1 ^@ http://purl.uniprot.org/uniprot/Q4R6K9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 75 kDa subunit family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Binds 2 [4Fe-4S] clusters per subunit.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity). Complex I associates with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (By similarity). Interacts with MDM2 and AKAP1 (By similarity).|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for catalysing the entry and efficient transfer of electrons within complex I (By similarity). Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ADAMTS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXG9 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:PLD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7U5|||http://purl.uniprot.org/uniprot/A0A2K5W7Y5|||http://purl.uniprot.org/uniprot/G7NZE7 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9541:DKK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1Y8 ^@ Similarity ^@ Belongs to the dickkopf family. http://togogenome.org/gene/9541:RPL10L ^@ http://purl.uniprot.org/uniprot/G7PA66|||http://purl.uniprot.org/uniprot/Q4R4D3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Component of the 60S large ribosomal subunit (LSU).|||Cytoplasm|||Testis-specific component of the ribosome, which is required for the transition from prophase to metaphase in male meiosis I (By similarity). Compensates for the inactivated X-linked RPL10 paralog during spermatogenesis. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (By similarity). http://togogenome.org/gene/9541:ADPRS ^@ http://purl.uniprot.org/uniprot/A0A2K5WFG0|||http://purl.uniprot.org/uniprot/G7NTI0 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/9541:TMED10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:LOC102134338 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CHMP4C ^@ http://purl.uniprot.org/uniprot/A0A2K5UK16|||http://purl.uniprot.org/uniprot/G7PC44 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9541:TUT7 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9I5|||http://purl.uniprot.org/uniprot/A0A2K5U9I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B-like family.|||Cytoplasm http://togogenome.org/gene/9541:FHL5 ^@ http://purl.uniprot.org/uniprot/A0A8J8YGZ4|||http://purl.uniprot.org/uniprot/G7P427|||http://purl.uniprot.org/uniprot/Q4R7A4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with CREM (via the third LIM domain). Interacts (via second LIM domain) with SPAG8.|||May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner (By similarity).|||May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.|||Nucleus http://togogenome.org/gene/9541:C2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0I4|||http://purl.uniprot.org/uniprot/G8F3W0 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:UGT3A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9541:SSBP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLN8|||http://purl.uniprot.org/uniprot/A0A2K5VLT6|||http://purl.uniprot.org/uniprot/A0A2K5VLU6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PROKR1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YIK3|||http://purl.uniprot.org/uniprot/G7PMD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9541:MRPL17 ^@ http://purl.uniprot.org/uniprot/A0A7N9CCT5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL17 family. http://togogenome.org/gene/9541:SMU1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W168|||http://purl.uniprot.org/uniprot/G7PS54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SMU1 family.|||Nucleus speckle http://togogenome.org/gene/9541:PARP9 ^@ http://purl.uniprot.org/uniprot/A0A2K5US48 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9541:CACNG5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXN9 ^@ Similarity ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. http://togogenome.org/gene/9541:SLC6A4 ^@ http://purl.uniprot.org/uniprot/A7KAX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.|||Cell membrane|||Endomembrane system|||Endosome membrane|||Membrane|||Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.|||Synapse|||focal adhesion http://togogenome.org/gene/9541:IMPDH2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y817|||http://purl.uniprot.org/uniprot/G7NXU9 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.|||Nucleus http://togogenome.org/gene/9541:CAT ^@ http://purl.uniprot.org/uniprot/A0A2K5X7W4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the catalase family.|||Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.|||Peroxisome http://togogenome.org/gene/9541:FPR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5URD3|||http://purl.uniprot.org/uniprot/A7ISL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:NAPEPLD ^@ http://purl.uniprot.org/uniprot/A0A2K5VL02 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAPE-PLD family.|||Binds 2 zinc divalent cations per subunit.|||Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.|||Nucleus envelope http://togogenome.org/gene/9541:TMEM8B ^@ http://purl.uniprot.org/uniprot/A0A2K5TXX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PDCD10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRK1|||http://purl.uniprot.org/uniprot/G7NZH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDCD10 family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:NDUFV1 ^@ http://purl.uniprot.org/uniprot/A8R0S3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 51 kDa subunit family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:TSPAN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:ACTB ^@ http://purl.uniprot.org/uniprot/Q25PW9|||http://purl.uniprot.org/uniprot/Q4R561 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.|||Belongs to the actin family.|||ISGylated.|||In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.|||Methylated at His-73 by SETD3 (By similarity). Methylation at His-73 is required for smooth muscle contraction of the laboring uterus during delivery (By similarity).|||Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.|||N-terminal acetylation by NAA80 affects actin filament depolymerization and elongation, including elongation driven by formins. In contrast, filament nucleation by the Arp2/3 complex is not affected.|||Nucleus|||Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization.|||Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with XPO6 and EMD. Interacts with ERBB2. Interacts with GCSAM (By similarity). Interacts with TBC1D21. Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (By similarity). Interacts with DHX9 (via C-terminus); this interaction is direct and mediates the attachment to nuclear ribonucleoprotein complexes. Interacts with FAM107A (By similarity).|||cytoskeleton http://togogenome.org/gene/9541:SEC62 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y6F9|||http://purl.uniprot.org/uniprot/G7NZF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC62 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:CNKSR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKH2|||http://purl.uniprot.org/uniprot/A0A2K5WKI3|||http://purl.uniprot.org/uniprot/A0A2K5WKN7|||http://purl.uniprot.org/uniprot/A0A2K5WKU7 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/9541:ZIC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLI C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9541:GLT6D1 ^@ http://purl.uniprot.org/uniprot/Q4R5T7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 6 family.|||Binds 1 Mn(2+) ion per subunit.|||Membrane http://togogenome.org/gene/9541:UCP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:LOC102123413 ^@ http://purl.uniprot.org/uniprot/A2V9Z5 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9541:TRMU ^@ http://purl.uniprot.org/uniprot/A0A2K5WXG0|||http://purl.uniprot.org/uniprot/A0A2K5WXH2 ^@ Function|||Similarity ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. http://togogenome.org/gene/9541:TAAR6 ^@ http://purl.uniprot.org/uniprot/A0A2K5URA5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:SPCS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:LOC101864869 ^@ http://purl.uniprot.org/uniprot/Q4R580 ^@ Function|||Similarity|||Subunit ^@ Component of the 40S subunit of the ribosome.|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Ribosomal protein S27a is part of the 40S ribosomal subunit. http://togogenome.org/gene/9541:MMP10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UY24|||http://purl.uniprot.org/uniprot/G7PNK4 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9541:NDUFC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCF8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFC1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ARRB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2Q9|||http://purl.uniprot.org/uniprot/A0A2K5W2V3|||http://purl.uniprot.org/uniprot/I7G9Z1 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9541:TSPAN17 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:GALC ^@ http://purl.uniprot.org/uniprot/A0A2K5U1A4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 59 family. http://togogenome.org/gene/9541:SLC35B2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WK53|||http://purl.uniprot.org/uniprot/A0A2K5WK56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9541:GSKIP ^@ http://purl.uniprot.org/uniprot/A0A2K5X3U9|||http://purl.uniprot.org/uniprot/G7PBF6|||http://purl.uniprot.org/uniprot/Q4R812 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (By similarity). May play a role in cleft palate formation and is required for postnatal life through modulation of the activity of GSK3B during development (By similarity).|||Belongs to the GSKIP family.|||Cytoplasm|||Forms a complex composed of PRKAR2A or PRKAR2B, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation of GSK3B leading to GSK3B inactivation; recruits DNM1L through GSK3B for PKA-mediated phosphorylation of DNM1L; promotes beta-catenin degradation through GSK3B-induced phosphorylation of beta-catenin; stabilizes beta-catenin and enhances Wnt-induced signaling through PKA-induced phosphorylation of beta-catenin. Interacts with GSK3B; induces GSK3B-mediated phosphorylation of GSKIP and inhibits GSK3B kinase activity.|||Nucleus|||Phosphorylated by GSK3B. http://togogenome.org/gene/9541:LYZL6 ^@ http://purl.uniprot.org/uniprot/Q4R8K7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9541:NOTCH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7N0|||http://purl.uniprot.org/uniprot/A0A2K5U7P6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOTCH family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Nucleus http://togogenome.org/gene/9541:CLDN8 ^@ http://purl.uniprot.org/uniprot/G7P1L5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:SLC39A2 ^@ http://purl.uniprot.org/uniprot/Q4R9D0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102126952 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:KRT18 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDB4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:ACTL6B ^@ http://purl.uniprot.org/uniprot/A0A2K5WNS5 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:ATP13A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VC67|||http://purl.uniprot.org/uniprot/A0A2K5VC90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Membrane http://togogenome.org/gene/9541:ITIH6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9541:NCR1 ^@ http://purl.uniprot.org/uniprot/Q95JB9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the natural cytotoxicity receptor (NCR) family.|||Cell membrane|||Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.|||Expressed in NK cells.|||Interacts with CD3Z and FCER1G. http://togogenome.org/gene/9541:CCL21 ^@ http://purl.uniprot.org/uniprot/C0ISS2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:INO80C ^@ http://purl.uniprot.org/uniprot/A0A2K5UGL3|||http://purl.uniprot.org/uniprot/A0A2K5UGV4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ATP2C2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WW06 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PPP2R2D ^@ http://purl.uniprot.org/uniprot/A0A2K5U729|||http://purl.uniprot.org/uniprot/A0A2K5U760 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9541:DUOXA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V772 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DUOXA family.|||Membrane http://togogenome.org/gene/9541:LEF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6A5|||http://purl.uniprot.org/uniprot/A0A2K5W6D6|||http://purl.uniprot.org/uniprot/A0A2K5W6D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/9541:GDI2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTB9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/9541:ACAD11 ^@ http://purl.uniprot.org/uniprot/A0A2K5WES4 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9541:UBE2D2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBG0|||http://purl.uniprot.org/uniprot/A0A2K5WBH8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:RHBDD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5USF3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:MLF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V446|||http://purl.uniprot.org/uniprot/Q4R7H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLF family.|||Cytoplasm http://togogenome.org/gene/9541:CCNDBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU69|||http://purl.uniprot.org/uniprot/A0A7N9DA24|||http://purl.uniprot.org/uniprot/Q4R809 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCNDBP1 family.|||Cytoplasm|||Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.|||May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription (By similarity).|||Nucleus|||Phosphorylated. http://togogenome.org/gene/9541:FBXO34 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEC7|||http://purl.uniprot.org/uniprot/G7PAC1 ^@ Function ^@ Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. http://togogenome.org/gene/9541:RETREG3 ^@ http://purl.uniprot.org/uniprot/I7G7Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Membrane http://togogenome.org/gene/9541:TCP11 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCV7|||http://purl.uniprot.org/uniprot/G7P2U7 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9541:USP11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJA3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:LOC102120479 ^@ http://purl.uniprot.org/uniprot/P61252 ^@ Function|||Miscellaneous|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Cell membrane|||Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins (By similarity).|||Homodimer; disulfide-linked. Heterohexamer composed of two subunits of KLRK1 and four subunits of HCST/DAP10. Interacts (via transmembrane domain) with HCST/DAP10 (via transmembrane domain); the interaction is required for KLRK1 NK cell surface and induces NK cell-mediated cytotoxicity. Can form disulfide-bonded heterodimer with CD94 (By similarity). Interacts with CEACAM1; recruits PTPN6 that dephosphorylates VAV1 (By similarity).|||Is not capable of signal transduction by itself, but operates through the adapter protein HCST.|||Natural killer cells. http://togogenome.org/gene/9541:PLEKHO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHI3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:MRPS5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VG54 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/9541:TAFA2 ^@ http://purl.uniprot.org/uniprot/I7GEP2 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9541:SPOPL ^@ http://purl.uniprot.org/uniprot/A0A2K5TT09|||http://purl.uniprot.org/uniprot/A0A8J8YI43 ^@ Similarity ^@ Belongs to the Tdpoz family. http://togogenome.org/gene/9541:LOC102119730 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQP4|||http://purl.uniprot.org/uniprot/G7P2L5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:CDK8 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7E0|||http://purl.uniprot.org/uniprot/G7PVW1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:GOLPH3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VT22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:S1PR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQL6|||http://purl.uniprot.org/uniprot/G7PZ68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9541:SH3KBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6X5|||http://purl.uniprot.org/uniprot/A0A2K5W718|||http://purl.uniprot.org/uniprot/A0A2K5W723 ^@ Subcellular Location Annotation ^@ focal adhesion http://togogenome.org/gene/9541:GDAP2 ^@ http://purl.uniprot.org/uniprot/Q4R678 ^@ Similarity ^@ Belongs to the GDAP2 family. http://togogenome.org/gene/9541:UCN2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CN39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Binds with high affinity to CRF receptors 2-alpha and 2-beta.|||Secreted|||Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. http://togogenome.org/gene/9541:ABHD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRR1|||http://purl.uniprot.org/uniprot/A0A7N9IG01 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/9541:AMZ2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WP99 ^@ Function|||Similarity ^@ Belongs to the peptidase M54 family.|||Probable zinc metalloprotease. http://togogenome.org/gene/9541:MED22 ^@ http://purl.uniprot.org/uniprot/A0A8J8YI95|||http://purl.uniprot.org/uniprot/G7PR93 ^@ Function|||Subcellular Location Annotation ^@ Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9541:NCBP1 ^@ http://purl.uniprot.org/uniprot/Q4R440 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NCBP1 family.|||Nucleus http://togogenome.org/gene/9541:CDC5L ^@ http://purl.uniprot.org/uniprot/A0A8J8YB92|||http://purl.uniprot.org/uniprot/G7P4R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEF1 family.|||Nucleus http://togogenome.org/gene/9541:NRN1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CHF2|||http://purl.uniprot.org/uniprot/A0A7N9CNJ8|||http://purl.uniprot.org/uniprot/G7P4C7 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/9541:PRKG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ44|||http://purl.uniprot.org/uniprot/A0A2K5VZ60 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. http://togogenome.org/gene/9541:ANXA10 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6U0 ^@ Similarity ^@ Belongs to the annexin family. http://togogenome.org/gene/9541:CDK2AP1 ^@ http://purl.uniprot.org/uniprot/A0A7N9DAR0|||http://purl.uniprot.org/uniprot/I7G9W9 ^@ Similarity ^@ Belongs to the CDK2AP family. http://togogenome.org/gene/9541:GADD45B ^@ http://purl.uniprot.org/uniprot/A0A8J8Y6A9|||http://purl.uniprot.org/uniprot/G7PYD1 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9541:RAB33B ^@ http://purl.uniprot.org/uniprot/A0A2K5W928 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/9541:PI4KB ^@ http://purl.uniprot.org/uniprot/A0A2K5UC81|||http://purl.uniprot.org/uniprot/A0A2K5UC84 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9541:NMD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMF5|||http://purl.uniprot.org/uniprot/A0A7N9DFA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.|||Belongs to the NMD3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:NAA30 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKM4 ^@ Similarity ^@ Belongs to the acetyltransferase family. MAK3 subfamily. http://togogenome.org/gene/9541:ZSCAN12 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRS2|||http://purl.uniprot.org/uniprot/A0A2K5WRY4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PDGFRA ^@ http://purl.uniprot.org/uniprot/A0A2K5WS53|||http://purl.uniprot.org/uniprot/Q0PW86 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.|||Membrane|||Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.|||Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. http://togogenome.org/gene/9541:PEX19 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWH5|||http://purl.uniprot.org/uniprot/G7NWC9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxin-19 family.|||Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.|||Membrane|||Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.|||Peroxisome membrane http://togogenome.org/gene/9541:SNAPC3 ^@ http://purl.uniprot.org/uniprot/Q4R6Y6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAPC3/SRD2 family.|||Nucleus|||Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1 (By similarity).|||Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity). http://togogenome.org/gene/9541:FAM163B ^@ http://purl.uniprot.org/uniprot/A0A2K5W0L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/9541:DNASE1L1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YRE0|||http://purl.uniprot.org/uniprot/G7Q218 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9541:SEC61A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:FES ^@ http://purl.uniprot.org/uniprot/A0A2K5VV58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.|||Cell membrane|||cytoskeleton http://togogenome.org/gene/9541:RABEP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rabaptin family.|||Cytoplasm|||Early endosome|||Endosome http://togogenome.org/gene/9541:SLC2A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane|||Photoreceptor inner segment http://togogenome.org/gene/9541:KIF20B ^@ http://purl.uniprot.org/uniprot/A0A2K5X3T5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:CDK10 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3L2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:LOC102126139 ^@ http://purl.uniprot.org/uniprot/A9CTP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9541:TPPP2 ^@ http://purl.uniprot.org/uniprot/G7P9N0|||http://purl.uniprot.org/uniprot/Q4R3A0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TPPP family.|||Probable regulator of microtubule dynamics required for sperm motility (By similarity). In contrast to other members of the family, has no microtubule bundling activity (By similarity).|||cytosol|||flagellum http://togogenome.org/gene/9541:OPN5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9541:MYH4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHF1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:PPFIA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U522 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/9541:CDADC1 ^@ http://purl.uniprot.org/uniprot/G7PVE6|||http://purl.uniprot.org/uniprot/Q4R683 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Catalyzes the deamination of cytidine and deoxycytidine into uridine and deoxyuridine, respectively. May play an important role in testicular development and spermatogenesis.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:PSENEN ^@ http://purl.uniprot.org/uniprot/A0A2K5U3R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PEN-2 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9541:SIRT4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X688 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.|||Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.|||Belongs to the sirtuin family. Class II subfamily.|||Binds 1 zinc ion per subunit.|||Interacts with GLUD1, IDE and SLC25A5. Interacts with DLAT and PDHX.|||Mitochondrion matrix http://togogenome.org/gene/9541:MAST2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V460 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9541:PHACTR4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZL8|||http://purl.uniprot.org/uniprot/A0A2K5WZS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin.|||Cytoplasm|||Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.|||lamellipodium http://togogenome.org/gene/9541:AP2S1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJQ9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).|||Belongs to the adaptor complexes small subunit family.|||Cell membrane|||coated pit http://togogenome.org/gene/9541:ERG28 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8J6|||http://purl.uniprot.org/uniprot/G7PB14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG28 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:TLR10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMV0|||http://purl.uniprot.org/uniprot/B3Y673 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9541:RPL7 ^@ http://purl.uniprot.org/uniprot/Q4R506 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Component of the large ribosomal subunit. Homodimer. Interacts with DHX33.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.|||Cytoplasm http://togogenome.org/gene/9541:SPATA20 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMU9|||http://purl.uniprot.org/uniprot/A0A2K5VMY6 ^@ Function|||Subcellular Location Annotation ^@ May play a role in fertility regulation.|||Secreted http://togogenome.org/gene/9541:MGST1 ^@ http://purl.uniprot.org/uniprot/C0SJM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/9541:GNPTAB ^@ http://purl.uniprot.org/uniprot/A0A2K5WMN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the stealth family.|||Membrane http://togogenome.org/gene/9541:TNFAIP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7A9|||http://purl.uniprot.org/uniprot/G7P325|||http://purl.uniprot.org/uniprot/Q4R8W3 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C64 family.|||Cytoplasm|||Homodimer. Interacts with TNIP1, TAX1BP1 and TRAF2. Interacts with RNF11, ITCH and TAX1BP1 only after TNF stimulation; these interaction are transient and they are lost after 1 hour of stimulation with TNF (By similarity). Interacts with YWHAZ and YWHAH. Interacts with IKBKG; the interaction is induced by TNF stimulation and by polyubiquitin. Interacts with RIPK1. Interacts with UBE2N; the interaction requires TAX1BP1. Interacts with TRAF6 (By similarity).|||Lysosome|||Nucleus|||Proteolytically cleaved by MALT1 upon TCR stimulation; disrupts NF-kappa-B inhibitory function and results in increased IL-2 production. It is proposed that only a fraction of TNFAIP3 colocalized with TCR and CBM complex is cleaved, leaving the main TNFAIP3 pool intact (By similarity).|||The A20-type zinc fingers mediate the ubiquitin ligase activity. The A20-type zinc finger 4 selectively recognizes 'Lys-63'-linked polyubiquitin. The A20-type zinc finger 4-7 are sufficient to bind polyubiquitin (By similarity).|||The OTU domain mediates the deubiquitinase activity.|||Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of pro-inflammatory cytokines and IFN beta in LPS-tolerized macrophages (By similarity). http://togogenome.org/gene/9541:MTCH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXV5|||http://purl.uniprot.org/uniprot/I7GNT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:TRPM8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VG97 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CACFD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNB4|||http://purl.uniprot.org/uniprot/A0A2K5TNB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel flower family.|||Membrane http://togogenome.org/gene/9541:LOC102123260 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJX0 ^@ Function|||Similarity ^@ Belongs to the SSX family.|||Could act as a modulator of transcription. http://togogenome.org/gene/9541:DPYSL5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN44 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9541:CRYBA2 ^@ http://purl.uniprot.org/uniprot/G7PK32 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9541:APOC3 ^@ http://purl.uniprot.org/uniprot/P18659 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C3 family.|||Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.|||Secreted|||The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan. http://togogenome.org/gene/9541:AKR1E2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V123|||http://purl.uniprot.org/uniprot/Q4R802 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aldo/keto reductase family.|||Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol.|||Cytoplasm|||Inhibited by p-chloromercuribenzoic acid and alkyliodines.|||Monomer. http://togogenome.org/gene/9541:SLC22A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6I5 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/9541:PRRX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1E8|||http://purl.uniprot.org/uniprot/A0A2K5V1G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9541:SLC46A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNL8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TRIM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5P8|||http://purl.uniprot.org/uniprot/A0A2K5V5W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:FOXN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWB7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PPIH ^@ http://purl.uniprot.org/uniprot/A0A2K5WFR7|||http://purl.uniprot.org/uniprot/A0A2K5WFS1 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9541:SEPTIN8 ^@ http://purl.uniprot.org/uniprot/I7GH31 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Presynapse|||Septins polymerize into heterooligomeric protein complexes that form filaments.|||synaptic vesicle membrane http://togogenome.org/gene/9541:PTPN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UB84|||http://purl.uniprot.org/uniprot/A0A2K5UBB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||May act at junctions between the membrane and the cytoskeleton.|||cytoskeleton http://togogenome.org/gene/9541:ING3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMH5|||http://purl.uniprot.org/uniprot/G7P0I8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9541:SERPINB11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VF95|||http://purl.uniprot.org/uniprot/A0A8J8Y381|||http://purl.uniprot.org/uniprot/G7PWX7 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:STMN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V041|||http://purl.uniprot.org/uniprot/A0A2K5V083|||http://purl.uniprot.org/uniprot/A0A7N9CHI2 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9541:CENPM ^@ http://purl.uniprot.org/uniprot/A0A2K5W0B1|||http://purl.uniprot.org/uniprot/A0A8J8XLD2|||http://purl.uniprot.org/uniprot/G7PFP3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:RELL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7N0|||http://purl.uniprot.org/uniprot/A0A2K5V7N4|||http://purl.uniprot.org/uniprot/G8F4X4 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9541:DNAJC27 ^@ http://purl.uniprot.org/uniprot/A0A7N9IHN1 ^@ Function|||Subunit ^@ GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.|||Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms). http://togogenome.org/gene/9541:GPC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSH0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan that bears heparan sulfate. http://togogenome.org/gene/9541:BEX3 ^@ http://purl.uniprot.org/uniprot/G7Q3C3 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9541:INS ^@ http://purl.uniprot.org/uniprot/P30406 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.|||Secreted http://togogenome.org/gene/9541:DAP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU77|||http://purl.uniprot.org/uniprot/A0A2K5UUC4|||http://purl.uniprot.org/uniprot/A0A2K5UUE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS29 family.|||Mitochondrion http://togogenome.org/gene/9541:CACNG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSB7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.|||Membrane|||Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.|||sarcolemma http://togogenome.org/gene/9541:CHST10 ^@ http://purl.uniprot.org/uniprot/A0A8J8XHX9|||http://purl.uniprot.org/uniprot/G7PMT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:SLC25A53 ^@ http://purl.uniprot.org/uniprot/A0A7N9CVE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:NPAS4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YIW1|||http://purl.uniprot.org/uniprot/G7PP95 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:GNG10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9541:GLI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V430 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLI C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9541:LOC102124556 ^@ http://purl.uniprot.org/uniprot/G7P1K9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9541:AQP10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9541:IRX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/9541:CCNL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPJ8|||http://purl.uniprot.org/uniprot/G7NZJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin L subfamily.|||Nucleus speckle|||nucleoplasm http://togogenome.org/gene/9541:OAS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-5A synthase family.|||Cytoplasm http://togogenome.org/gene/9541:KRT10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPI4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:LOC102120481 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9N2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PIP family.|||Monomer. Interacts with AZGP1.|||Secreted http://togogenome.org/gene/9541:RAD23B ^@ http://purl.uniprot.org/uniprot/I7GMN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/9541:LOC102131557 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWH0 ^@ Similarity ^@ Belongs to the ficolin lectin family. http://togogenome.org/gene/9541:NME1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDV1 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9541:VARS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U944 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:MNS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MNS1 family.|||Nucleus|||cilium axoneme|||flagellum axoneme http://togogenome.org/gene/9541:LOC102131576 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST5 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9541:NFIX ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ42|||http://purl.uniprot.org/uniprot/I7GMK9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/9541:EXOSC8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UL24 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:ANKRD34B ^@ http://purl.uniprot.org/uniprot/A0A8J8XFW9|||http://purl.uniprot.org/uniprot/G7P7V3 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/9541:GNAL ^@ http://purl.uniprot.org/uniprot/A0A2K5VL29 ^@ Similarity ^@ Belongs to the G-alpha family. G(s) subfamily. http://togogenome.org/gene/9541:RNF167 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4U4|||http://purl.uniprot.org/uniprot/G7PT98 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PPP6R2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6N3 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/9541:GLB1L3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UB00 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/9541:SFTPD ^@ http://purl.uniprot.org/uniprot/A0A2K5VUW3 ^@ Similarity|||Subunit ^@ Belongs to the SFTPD family.|||Oligomeric complex of 4 set of homotrimers. http://togogenome.org/gene/9541:SCFD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ06 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9541:SLC10A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9541:ST13 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0P1 ^@ Similarity ^@ Belongs to the FAM10 family. http://togogenome.org/gene/9541:GFM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WX80 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.|||Mitochondrion http://togogenome.org/gene/9541:ERBB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0D3|||http://purl.uniprot.org/uniprot/A0A2K5W0D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9541:CBLL1 ^@ http://purl.uniprot.org/uniprot/Q4R7I8 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Hakai family.|||Cytoplasm|||E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown.|||Homodimer. Interacts with tyrosine-phosphorylated SRC substrates. Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM. The MAC subcomplex is composed of METTL3 and METTL14. The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (By similarity). Also a component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, VIRMA, RBM15, BCLAF1 and THRAP3 (By similarity).|||Nucleus speckle|||Phosphorylated on tyrosine residues.|||The HYB domain forms a phosphotyrosine-binding pocket upon dimerization, and mediates as well the recognition of its flanking acidic amino acids.|||nucleoplasm http://togogenome.org/gene/9541:PCNA ^@ http://purl.uniprot.org/uniprot/P61258 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated by CREBBP and p300/EP300; preferentially acetylated by CREBBP on Lys-80, Lys-13 and Lys-14 and on Lys-77 by p300/EP300 upon loading on chromatin in response to UV irradiation. Lysine acetylation disrupts association with chromatin, hence promoting PCNA ubiquitination and proteasomal degradation in response to UV damage in a CREBBP- and EP300-dependent manner. Acetylation disrupts interaction with NUDT15 and promotes degradation (By similarity).|||Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (By similarity).|||Belongs to the PCNA family.|||Homotrimer. Interacts with p300/EP300; the interaction occurs on chromatin in UV-irradiated damaged cells. Interacts with CREBBP (via transactivation domain and C-terminus); the interaction occurs on chromatin in UV-irradiated damaged cells. Directly interacts with POLD1, POLD3 and POLD4 subunits of the DNA polymerase delta complex, POLD3 being the major interacting partner; the interaction with POLD3 is inhibited by CDKN1A/p21(CIP1). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with EXO1, POLH, POLK, DNMT1, ERCC5, FEN1, CDC6 and POLDIP2. Interacts with APEX2; this interaction is triggered by reactive oxygen species and increased by misincorporation of uracil in nuclear DNA. Forms a ternary complex with DNTTIP2 and core histone (By similarity). Interacts with KCTD10 and PPP1R15A (By similarity). Interacts with SMARCA5/SNF2H (By similarity). Interacts with BAZ1B/WSTF; the interaction is direct and is required for BAZ1B/WSTF binding to replication foci during S phase (By similarity). Interacts with HLTF and SHPRH. Interacts with NUDT15; this interaction is disrupted in response to UV irradiation and acetylation. Interacts with CDKN1A/p21(CIP1) and CDT1; interacts via their PIP-box which also recruits the DCX(DTL) complex. The interaction with CDKN1A inhibits POLD3 binding. Interacts with DDX11. Interacts with EGFR; positively regulates PCNA. Interacts with PARPBP. Interacts (when ubiquitinated) with SPRTN; leading to enhance RAD18-mediated PCNA ubiquitination. Interacts (when polyubiquitinated) with ZRANB3. Interacts with SMARCAD1. Interacts with CDKN1C. Interacts with PCLAF (via PIP-box). Interacts with RTEL1 (via PIP-box); the interaction is direct and essential for the suppression of telomere fragility. Interacts with FAM111A (via PIP-box); the interaction is direct and required for PCNA loading on chromatin binding. Interacts with LIG1. Interacts with SETMAR. Interacts with ANKRD17. Interacts with FBXO18/FBH1 (via PIP-box); the interaction recruits the DCX(DTL) complex and promotes ubiquitination and degradation of FBXO18/FBH1. Interacts with POLN (By similarity). Interacts with SDE2 (via PIP-box); the interaction is direct and prevents ultraviolet light induced monoubiquitination (By similarity). Component of the replisome complex composed of at least DONSON, MCM2, MCM7, PCNA and TICRR; interaction at least with PCNA occurs during DNA replication (By similarity). Interacts with MAPK15; the interaction is chromatin binding dependent and prevents MDM2-mediated PCNA destruction by inhibiting the association of PCNA with MDM2. Interacts with PARP10 (via PIP-box) (By similarity). Interacts with DDI2 (By similarity). Interacts with HMCES (via PIP-box) (By similarity). Interacts with TRAIP (via PIP-box) (By similarity). Interacts with UHRF2 (By similarity). Interacts with ALKBH2; this interaction is enhanced during the S-phase of the cell cycle. Interacts with ATAD5; the interaction promotes USP1-mediated PCNA deubiquitination (By similarity).|||Methylated on glutamate residues by ARMT1.|||Nucleus|||Phosphorylated. Phosphorylation at Tyr-211 by EGFR stabilizes chromatin-associated PCNA (By similarity).|||Ubiquitinated. Following DNA damage, can be either monoubiquitinated to stimulate direct bypass of DNA lesions by specialized DNA polymerases or polyubiquitinated to promote recombination-dependent DNA synthesis across DNA lesions by template switching mechanisms. Following induction of replication stress, monoubiquitinated by the UBE2B-RAD18 complex on Lys-164, leading to recruit translesion (TLS) polymerases, which are able to synthesize across DNA lesions in a potentially error-prone manner. An error-free pathway also exists and requires non-canonical polyubiquitination on Lys-164 through 'Lys-63' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligases, HLTF, RNF8 and SHPRH. This error-free pathway, also known as template switching, employs recombination mechanisms to synthesize across the lesion, using as a template the undamaged, newly synthesized strand of the sister chromatid. Monoubiquitination at Lys-164 also takes place in undamaged proliferating cells, and is mediated by the DCX(DTL) complex, leading to enhance PCNA-dependent translesion DNA synthesis. Sumoylated during S phase (By similarity). http://togogenome.org/gene/9541:DNTTIP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJF3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PHTF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPZ5|||http://purl.uniprot.org/uniprot/G7NW72 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CCNC ^@ http://purl.uniprot.org/uniprot/A0A2K5USI3|||http://purl.uniprot.org/uniprot/A0A2K5USJ7|||http://purl.uniprot.org/uniprot/G7P437 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin C subfamily.|||Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.|||Nucleus http://togogenome.org/gene/9541:GEM ^@ http://purl.uniprot.org/uniprot/A0A8J8YSC9|||http://purl.uniprot.org/uniprot/G7PC82 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9541:KLHL22 ^@ http://purl.uniprot.org/uniprot/G7PH96 ^@ Subcellular Location Annotation ^@ Lysosome|||Nucleus|||centrosome|||cytosol|||spindle http://togogenome.org/gene/9541:FAT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VB26|||http://purl.uniprot.org/uniprot/A0A2K5VB61 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:HMGCL ^@ http://purl.uniprot.org/uniprot/Q8HXZ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HMG-CoA lyase family.|||Homodimer; disulfide-linked. Can also form homotetramers.|||Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.|||Mitochondrion matrix|||Peroxisome http://togogenome.org/gene/9541:LOC102126170 ^@ http://purl.uniprot.org/uniprot/E7EDU3 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:CIBAR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3N7|||http://purl.uniprot.org/uniprot/A0A2K5V3T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CIBAR family.|||centriole|||cilium basal body http://togogenome.org/gene/9541:AP3M2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUX3|||http://purl.uniprot.org/uniprot/A0A7N9DGA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus http://togogenome.org/gene/9541:MYH11 ^@ http://purl.uniprot.org/uniprot/A0A2K5W527|||http://purl.uniprot.org/uniprot/A0A2K5W551|||http://purl.uniprot.org/uniprot/A0A2K5W599 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:LOC102131517 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9541:CPXM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Secreted http://togogenome.org/gene/9541:MDM4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TL15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.|||Nucleus http://togogenome.org/gene/9541:HBM ^@ http://purl.uniprot.org/uniprot/A0A2K5W0M5 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9541:LOC102128179 ^@ http://purl.uniprot.org/uniprot/A0A8J8XL53|||http://purl.uniprot.org/uniprot/G7P5Z2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:SATB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VY58|||http://purl.uniprot.org/uniprot/A0A7N9CMF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/9541:NR3C1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPH3|||http://purl.uniprot.org/uniprot/G7P8J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Mitochondrion|||Nucleus|||centrosome|||spindle http://togogenome.org/gene/9541:HS2ST1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVH9|||http://purl.uniprot.org/uniprot/G7NTM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Membrane http://togogenome.org/gene/9541:MEMO1 ^@ http://purl.uniprot.org/uniprot/Q4R6D9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MEMO1 family.|||Interacts with ERBB2.|||May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). http://togogenome.org/gene/9541:RAB3GAP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y6F7|||http://purl.uniprot.org/uniprot/G7NTY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab3-GAP regulatory subunit family.|||Cytoplasm http://togogenome.org/gene/9541:UBE2K ^@ http://purl.uniprot.org/uniprot/I7GKU5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:BTG1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CIC1 ^@ Function|||Similarity ^@ Anti-proliferative protein.|||Belongs to the BTG family. http://togogenome.org/gene/9541:DEDD ^@ http://purl.uniprot.org/uniprot/A0A8J8XXP3|||http://purl.uniprot.org/uniprot/G7NXA0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9541:LIPI ^@ http://purl.uniprot.org/uniprot/A0A2K5TZA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9541:C1H1orf74 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNI5 ^@ Similarity ^@ Belongs to the UPF0739 family. http://togogenome.org/gene/9541:HYAL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGW3|||http://purl.uniprot.org/uniprot/A0A2K5VH22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 56 family.|||Cell membrane|||Early endosome|||Endoplasmic reticulum|||Endosome|||Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage.|||Membrane|||acrosome http://togogenome.org/gene/9541:RPL26 ^@ http://purl.uniprot.org/uniprot/G7P624|||http://purl.uniprot.org/uniprot/P61256 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Component of the large ribosomal subunit. Interacts with DHX33.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm|||Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets. http://togogenome.org/gene/9541:CALHM3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEF3|||http://purl.uniprot.org/uniprot/G7PDW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9541:LOC102120861 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUI2|||http://purl.uniprot.org/uniprot/G7PXX3 ^@ Function|||Similarity ^@ Belongs to the OPA3 family.|||May play some role in mitochondrial processes. http://togogenome.org/gene/9541:LSM14B ^@ http://purl.uniprot.org/uniprot/A0A2K5WW67|||http://purl.uniprot.org/uniprot/A0A2K5WWR6 ^@ Similarity ^@ Belongs to the LSM14 family. http://togogenome.org/gene/9541:GADD45A ^@ http://purl.uniprot.org/uniprot/A0A2K5VD54 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9541:UBE3A ^@ http://purl.uniprot.org/uniprot/A0A2K5TLG4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.|||Nucleus http://togogenome.org/gene/9541:SLITRK6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPB1|||http://purl.uniprot.org/uniprot/G7PVK4 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9541:ASB5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X880|||http://purl.uniprot.org/uniprot/A0A2K5X881 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:CHD9 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVV9 ^@ Similarity ^@ Belongs to the SNF2/RAD54 helicase family. http://togogenome.org/gene/9541:MPC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WT03|||http://purl.uniprot.org/uniprot/G8F4T1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:USP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UA78|||http://purl.uniprot.org/uniprot/G7PJN7 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9541:PIERCE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCQ0|||http://purl.uniprot.org/uniprot/G8F5E5 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.|||cilium axoneme http://togogenome.org/gene/9541:EXOC6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9K0|||http://purl.uniprot.org/uniprot/A0A2K5U9N7|||http://purl.uniprot.org/uniprot/A0A7N9CLZ1 ^@ Function|||Similarity ^@ Belongs to the SEC15 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9541:ADAM11 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9H2|||http://purl.uniprot.org/uniprot/A0A2K5V9H4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:FZR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WA62 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/9541:SLC25A42 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:VAMP8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9541:TRPM3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZB2|||http://purl.uniprot.org/uniprot/A0A2K5X003|||http://purl.uniprot.org/uniprot/A0A2K5X085 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102131764 ^@ http://purl.uniprot.org/uniprot/I7GE34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9541:CBS ^@ http://purl.uniprot.org/uniprot/Q58H57 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by S-adenosyl-methionine/AdoMet. Activated by S-adenosylhomocysteine/AdoHcy. Binds non-covalently to a heme group that may control the redox sensitivity of the enzyme.|||Belongs to the cysteine synthase/cystathionine beta-synthase family.|||Cytoplasm|||Homotetramer.|||Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).|||Nucleus http://togogenome.org/gene/9541:ATP5MC1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y9Z4|||http://purl.uniprot.org/uniprot/G7P524 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9541:LEPROTL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/9541:LOC102124658 ^@ http://purl.uniprot.org/uniprot/I7GPH0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/9541:FDPS ^@ http://purl.uniprot.org/uniprot/A0A2K5W8T2|||http://purl.uniprot.org/uniprot/I7GHV0 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9541:TAS2R3 ^@ http://purl.uniprot.org/uniprot/A0A7N9DBR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9541:MTCH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3W3|||http://purl.uniprot.org/uniprot/G7PQ88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:SEC22A ^@ http://purl.uniprot.org/uniprot/G7NYD2|||http://purl.uniprot.org/uniprot/Q4R866 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/9541:MANBAL ^@ http://purl.uniprot.org/uniprot/A0A8J8XIZ4|||http://purl.uniprot.org/uniprot/G7PGF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0239 family.|||Membrane http://togogenome.org/gene/9541:PRKG2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQ94|||http://purl.uniprot.org/uniprot/G7P527 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. http://togogenome.org/gene/9541:ZSCAN25 ^@ http://purl.uniprot.org/uniprot/A0A7N9IAK5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:AGPAT4 ^@ http://purl.uniprot.org/uniprot/G7P480|||http://purl.uniprot.org/uniprot/Q4R581 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (By similarity).|||Endoplasmic reticulum membrane|||Membrane|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/9541:SLC6A9 ^@ http://purl.uniprot.org/uniprot/A0A2K5X926|||http://purl.uniprot.org/uniprot/A0A2K5X967|||http://purl.uniprot.org/uniprot/A0A2K5X9I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:DGAT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCG5|||http://purl.uniprot.org/uniprot/G7PNA0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ZKSCAN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VV45 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SH3BP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WM65 ^@ Subcellular Location Annotation ^@ Nucleus|||Vesicle|||clathrin-coated pit|||clathrin-coated vesicle http://togogenome.org/gene/9541:KEG98_p01 ^@ http://purl.uniprot.org/uniprot/C3W4Z7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Membrane|||Mitochondrion inner membrane|||The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer. http://togogenome.org/gene/9541:ANGPTL4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAE0 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:RFC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WN91 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/9541:HMGCS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMZ2|||http://purl.uniprot.org/uniprot/G7P7G3|||http://purl.uniprot.org/uniprot/I7GL51 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/9541:SEMA6D ^@ http://purl.uniprot.org/uniprot/A0A2K5WSJ5|||http://purl.uniprot.org/uniprot/A0A2K5WSQ4|||http://purl.uniprot.org/uniprot/A0A2K5WSS0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:TM2D2 ^@ http://purl.uniprot.org/uniprot/G7PD79 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:KRT38 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNE6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:SPTBN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAC7|||http://purl.uniprot.org/uniprot/A0A2K5WAK6 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/9541:ALOX15 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRD0 ^@ Caution|||Similarity ^@ Belongs to the lipoxygenase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:CCNI ^@ http://purl.uniprot.org/uniprot/A0A2K5U1L4|||http://purl.uniprot.org/uniprot/A0A7N9CZQ9 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9541:GPR61 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCD3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:QPCTL ^@ http://purl.uniprot.org/uniprot/G8F4B6|||http://purl.uniprot.org/uniprot/Q4R942 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutaminyl-peptide cyclotransferase family.|||Golgi apparatus membrane|||It is unclear whether this protein requires a metal cofactor for catalysis. It was originally proposed to be a Zn(2+)-dependent metalloenzyme based on structural similarities to bacterial aminopeptidases and the observation that it can bind Zn(2+) ions, typically in a 1:1 stoichiometry (By similarity). However, a recent study suggests a Zn(2+)-independent catalytic mechanism (By similarity).|||Responsible for the biosynthesis of pyroglutamyl peptides. http://togogenome.org/gene/9541:LOC102132200 ^@ http://purl.uniprot.org/uniprot/Q9BE00 ^@ Similarity ^@ Belongs to the ficolin lectin family. http://togogenome.org/gene/9541:LOC102133861 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102119981 ^@ http://purl.uniprot.org/uniprot/G8F3V0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:ITPKB ^@ http://purl.uniprot.org/uniprot/A0A2K5VB40 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9541:GATA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WN29 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CRPPA ^@ http://purl.uniprot.org/uniprot/A0A2K5WUW5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Homodimer.|||cytosol http://togogenome.org/gene/9541:ADAMTS4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X742 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:ADPRM ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5L1|||http://purl.uniprot.org/uniprot/G7PTN6 ^@ Similarity|||Subunit ^@ Belongs to the ADPRibase-Mn family.|||Monomer. http://togogenome.org/gene/9541:ASPN ^@ http://purl.uniprot.org/uniprot/I7GCG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||extracellular matrix http://togogenome.org/gene/9541:LOC102145245 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ93|||http://purl.uniprot.org/uniprot/G7PE14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9541:MAB21L2 ^@ http://purl.uniprot.org/uniprot/I7G842 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mab-21 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:TSPAN12 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYI1|||http://purl.uniprot.org/uniprot/G7P0I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:MRPL11 ^@ http://purl.uniprot.org/uniprot/A0A8J8XSM2|||http://purl.uniprot.org/uniprot/G7PP94 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/9541:RARRES2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFF6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:ECRG4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2S1 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the augurin family.|||Cytoplasm|||Membrane|||Secreted http://togogenome.org/gene/9541:VOPP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VOPP1/ECOP family.|||Cytoplasmic vesicle membrane|||Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.|||Membrane http://togogenome.org/gene/9541:KCNE2 ^@ http://purl.uniprot.org/uniprot/G7P124 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9541:RO60 ^@ http://purl.uniprot.org/uniprot/A0A8J8YFB4|||http://purl.uniprot.org/uniprot/G7NXD9|||http://purl.uniprot.org/uniprot/I7GPE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ro 60 kDa family.|||Cytoplasm http://togogenome.org/gene/9541:NSMCE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NSE2 family.|||Nucleus http://togogenome.org/gene/9541:GUCA2B ^@ http://purl.uniprot.org/uniprot/A0A8J8YK19|||http://purl.uniprot.org/uniprot/G7NUE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/9541:RORC ^@ http://purl.uniprot.org/uniprot/A0A2K5UAQ9|||http://purl.uniprot.org/uniprot/A0A2K5UAT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9541:ST8SIA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:AZIN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2C9 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9541:CMC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQX3 ^@ Similarity ^@ Belongs to the CMC4 family. http://togogenome.org/gene/9541:UBE2L6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYS3|||http://purl.uniprot.org/uniprot/A0A2K5TYU5|||http://purl.uniprot.org/uniprot/A0A7N9DDL7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:LRWD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRWD1 family.|||centrosome|||kinetochore|||telomere http://togogenome.org/gene/9541:RAB9A ^@ http://purl.uniprot.org/uniprot/A0A8J8Y101|||http://purl.uniprot.org/uniprot/G7Q287 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/9541:DR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2D5 ^@ Similarity ^@ Belongs to the NC2 beta/DR1 family. http://togogenome.org/gene/9541:CBWD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPJ7|||http://purl.uniprot.org/uniprot/A0A2K5VPK4|||http://purl.uniprot.org/uniprot/A0A7N9CTQ2 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily. http://togogenome.org/gene/9541:PTK7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNI5|||http://purl.uniprot.org/uniprot/A0A2K5VNQ5|||http://purl.uniprot.org/uniprot/A0A2K5VNQ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CENPS ^@ http://purl.uniprot.org/uniprot/A0A7N9D2J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family. CENP-S/MHF1 subfamily.|||Nucleus|||kinetochore http://togogenome.org/gene/9541:PIGG ^@ http://purl.uniprot.org/uniprot/A0A2K5V853 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:MDM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2P1|||http://purl.uniprot.org/uniprot/G7PI02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Cytoplasm|||nucleolus|||nucleoplasm http://togogenome.org/gene/9541:SLC6A18 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9541:OSTN ^@ http://purl.uniprot.org/uniprot/G7NYP9 ^@ Caution|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Osteocrin family.|||Expression is induced by neuronal activity in the developing cerebral cortex: expression is driven by the presence of a enhancer sequence only present in primates that binds the MEF2 transcription factors (PubMed:27830782).|||Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience. Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (By similarity). Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity).|||Interacts with NPR3.|||Secreted|||This protein-coding gene has been repurposed in primates, with the presence of a new enhancer sequence that drives expression in brain in response to sensory experience, leading to restrict dendritic growth in the developing cortex (PubMed:27830782). http://togogenome.org/gene/9541:CDK14 ^@ http://purl.uniprot.org/uniprot/A0A2K5VR79|||http://purl.uniprot.org/uniprot/A0A2K5VRA3|||http://purl.uniprot.org/uniprot/A0A7N9DC80|||http://purl.uniprot.org/uniprot/I7GGZ8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:ATP2A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U839 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9541:ADGB ^@ http://purl.uniprot.org/uniprot/A0A2K5V9S6 ^@ Caution|||Similarity ^@ Belongs to the peptidase C2 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:UCMA ^@ http://purl.uniprot.org/uniprot/A0A2K5VEZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UCMA family.|||May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.|||extracellular matrix http://togogenome.org/gene/9541:RCE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase U48 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:LOC102137365 ^@ http://purl.uniprot.org/uniprot/A0A2K5UF51 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:DNAJC24 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDF8 ^@ Similarity ^@ Belongs to the DPH4 family. http://togogenome.org/gene/9541:FLNB ^@ http://purl.uniprot.org/uniprot/A0A2K5WH26|||http://purl.uniprot.org/uniprot/A0A2K5WHB3|||http://purl.uniprot.org/uniprot/A0A2K5WHC8 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/9541:DCLK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UP37|||http://purl.uniprot.org/uniprot/A0A2K5UP49|||http://purl.uniprot.org/uniprot/A0A2K5UP70|||http://purl.uniprot.org/uniprot/A0A8J8XX00|||http://purl.uniprot.org/uniprot/G7PW04 ^@ Similarity ^@ Belongs to the protein kinase superfamily.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9541:VPS35L ^@ http://purl.uniprot.org/uniprot/A0A2K5W7T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS35L family.|||Endosome http://togogenome.org/gene/9541:CNGA1 ^@ http://purl.uniprot.org/uniprot/A0A7N9IH56 ^@ Function|||Similarity ^@ Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily.|||Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential. http://togogenome.org/gene/9541:PPP2R5A ^@ http://purl.uniprot.org/uniprot/A0A2K5WHQ3|||http://purl.uniprot.org/uniprot/G7NUM0 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9541:SMARCA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ87|||http://purl.uniprot.org/uniprot/A0A2K5TZG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.|||Nucleus http://togogenome.org/gene/9541:LOC102121277 ^@ http://purl.uniprot.org/uniprot/A0A2K5UG77|||http://purl.uniprot.org/uniprot/G7PVW5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9541:MEOX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMY3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NIPSNAP3A ^@ http://purl.uniprot.org/uniprot/A0A8J8Y936|||http://purl.uniprot.org/uniprot/G7PRS1 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/9541:SNRPN ^@ http://purl.uniprot.org/uniprot/Q25QJ5|||http://purl.uniprot.org/uniprot/Q60HD3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP SmB/SmN family.|||Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.|||Interacts with TDRD3.|||May be involved in tissue-specific alternative RNA processing events.|||Nucleus http://togogenome.org/gene/9541:ATP6V1D ^@ http://purl.uniprot.org/uniprot/Q4R702 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase D subunit family.|||cilium|||clathrin-coated vesicle membrane http://togogenome.org/gene/9541:ATXN10 ^@ http://purl.uniprot.org/uniprot/Q25LJ1|||http://purl.uniprot.org/uniprot/Q4R4Y2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ataxin-10 family.|||Homooligomer. Interacts with OGT. Interacts with GNB2. Interacts with IQCB1.|||Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.|||perinuclear region http://togogenome.org/gene/9541:IMMP1L ^@ http://purl.uniprot.org/uniprot/A0A2K5UQ55 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family.|||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:PRDM5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1G2|||http://purl.uniprot.org/uniprot/A0A2K5U1H8|||http://purl.uniprot.org/uniprot/A0A2K5U1I4|||http://purl.uniprot.org/uniprot/A0A2K5U1K9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MRPL44 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.|||Mitochondrion http://togogenome.org/gene/9541:B3GALT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:SULF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBL4|||http://purl.uniprot.org/uniprot/A0A2K5VBR2 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Endoplasmic reticulum|||Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9541:ACAN ^@ http://purl.uniprot.org/uniprot/A0A2K5UIA3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aggrecan/versican proteoglycan family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:LMBR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UY93|||http://purl.uniprot.org/uniprot/A0A2K5UYG8 ^@ Similarity ^@ Belongs to the LIMR family. http://togogenome.org/gene/9541:LAMC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W249 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/9541:CHI3L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAY0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 18 family.|||Cytoplasm|||Endoplasmic reticulum|||Monomer.|||extracellular space http://togogenome.org/gene/9541:LOC101865064 ^@ http://purl.uniprot.org/uniprot/G7Q3C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family. TFA subfamily.|||Nucleus http://togogenome.org/gene/9541:CHMP2B ^@ http://purl.uniprot.org/uniprot/A0A8J8XYL2|||http://purl.uniprot.org/uniprot/G7NZ52 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9541:LOC102116067 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZT1 ^@ Similarity ^@ Belongs to the SCO1/2 family. http://togogenome.org/gene/9541:HNF1B ^@ http://purl.uniprot.org/uniprot/A0A2K5URN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HNF1 homeobox family.|||Nucleus http://togogenome.org/gene/9541:UBE2R2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V571 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:INO80D ^@ http://purl.uniprot.org/uniprot/A0A2K5TUN5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:GM2A ^@ http://purl.uniprot.org/uniprot/Q8HXX6 ^@ Function|||Subcellular Location Annotation ^@ Lysosome|||The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 (By similarity). Has cholesterol transfer activity (By similarity). http://togogenome.org/gene/9541:SAP30 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJY1 ^@ Similarity ^@ Belongs to the SAP30 family. http://togogenome.org/gene/9541:LOC101866265 ^@ http://purl.uniprot.org/uniprot/A0A2K5UB93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/9541:ARFGAP3 ^@ http://purl.uniprot.org/uniprot/Q4R4C9 ^@ Activity Regulation|||Function|||Subcellular Location Annotation ^@ Cytoplasm|||GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2).|||GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity).|||Golgi apparatus membrane http://togogenome.org/gene/9541:PNPLA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WF70|||http://purl.uniprot.org/uniprot/A0A7N9CTG8|||http://purl.uniprot.org/uniprot/A0A7N9D1X4|||http://purl.uniprot.org/uniprot/A0A8J8XB00|||http://purl.uniprot.org/uniprot/G7Q263 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:KRT81 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWC1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:IGFBP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VE67 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC102124317 ^@ http://purl.uniprot.org/uniprot/A0A8J8XNH7|||http://purl.uniprot.org/uniprot/G7P2M2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:OVOL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIA9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MEF2C ^@ http://purl.uniprot.org/uniprot/A0A2K5VQ99|||http://purl.uniprot.org/uniprot/A0A2K5VQA6|||http://purl.uniprot.org/uniprot/A0A2K5VQF2|||http://purl.uniprot.org/uniprot/A0A7N9IBE8|||http://purl.uniprot.org/uniprot/G7P7X2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TFCP2L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9541:KPNA1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYJ5|||http://purl.uniprot.org/uniprot/G7NXS0 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9541:GPR137 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVD9|||http://purl.uniprot.org/uniprot/A0A7N9CBZ7 ^@ Subcellular Location Annotation ^@ Lysosome membrane|||Membrane http://togogenome.org/gene/9541:ST8SIA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6P7|||http://purl.uniprot.org/uniprot/G7P804 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:ZDHHC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWE7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:EBF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WH55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/9541:PDGFB ^@ http://purl.uniprot.org/uniprot/A0A2K5UX81 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9541:GSTA4 ^@ http://purl.uniprot.org/uniprot/G7P4V9 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9541:PFN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGF2 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/9541:IL17A ^@ http://purl.uniprot.org/uniprot/A0A2K5TTB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9541:LCTL ^@ http://purl.uniprot.org/uniprot/A0A2K5X7J3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/9541:TUBB ^@ http://purl.uniprot.org/uniprot/A0A2K5WBU4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9541:VIRMA ^@ http://purl.uniprot.org/uniprot/A0A2K5VWG2 ^@ Similarity ^@ Belongs to the vir family. http://togogenome.org/gene/9541:ASL ^@ http://purl.uniprot.org/uniprot/A0A7N9DER3 ^@ Similarity ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. http://togogenome.org/gene/9541:SLC26A11 ^@ http://purl.uniprot.org/uniprot/A0A2K5V245 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CENPE ^@ http://purl.uniprot.org/uniprot/A0A2K5X589|||http://purl.uniprot.org/uniprot/A0A2K5X594 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:CSGALNACT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHT9|||http://purl.uniprot.org/uniprot/A0A2K5UHW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9541:AGAP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WI02 ^@ Similarity ^@ Belongs to the centaurin gamma-like family. http://togogenome.org/gene/9541:RPS17 ^@ http://purl.uniprot.org/uniprot/I7GPH0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/9541:PRDM10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UT66|||http://purl.uniprot.org/uniprot/A0A2K5UT67|||http://purl.uniprot.org/uniprot/A0A2K5UT82 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:HSPA13 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTB4|||http://purl.uniprot.org/uniprot/G7P242 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Binds UBQLN2.|||Endoplasmic reticulum|||Has peptide-independent ATPase activity.|||Microsome http://togogenome.org/gene/9541:CD247 ^@ http://purl.uniprot.org/uniprot/Q09TJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD3Z/FCER1G family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:GABRB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8N5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:GABRG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLM2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:MFNG ^@ http://purl.uniprot.org/uniprot/A0A2K5U657|||http://purl.uniprot.org/uniprot/A0A7N9I9E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:PDGFD ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ43 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the PDGF/VEGF growth factor family.|||Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:SELENOS ^@ http://purl.uniprot.org/uniprot/A0A2K5U765|||http://purl.uniprot.org/uniprot/A0A2K5U789 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selenoprotein S family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.|||Membrane http://togogenome.org/gene/9541:TMBIM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9541:KCNB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.|||Cell membrane|||Lateral cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synaptic cell membrane|||axon|||sarcolemma|||synaptosome http://togogenome.org/gene/9541:CNDP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2T5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9541:HIGD1B ^@ http://purl.uniprot.org/uniprot/A0A7N9DBW9 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9541:CS ^@ http://purl.uniprot.org/uniprot/A0A2K5TY26|||http://purl.uniprot.org/uniprot/G7PIH5|||http://purl.uniprot.org/uniprot/P0C1Z2 ^@ Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the citrate synthase family.|||Citrate synthase is found in nearly all cells capable of oxidative metabolism.|||Homodimer.|||Methylated. Trimethylation at Lys-395 by CSKMT decreases citrate synthase activity.|||Mitochondrion matrix http://togogenome.org/gene/9541:MEAF6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRM5|||http://purl.uniprot.org/uniprot/A0A2K5TRN7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EAF6 family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.|||Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.|||kinetochore|||nucleolus http://togogenome.org/gene/9541:LOC101866793 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8L4|||http://purl.uniprot.org/uniprot/A0A2K5X8P9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 2H phosphoesterase superfamily. CNPase family.|||Exists as monomers and homodimers.|||May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.|||Melanosome|||Membrane http://togogenome.org/gene/9541:PHYKPL ^@ http://purl.uniprot.org/uniprot/A0A2K5WDC0 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9541:ARL9 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4B6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9541:ZKSCAN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UP95 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102133566 ^@ http://purl.uniprot.org/uniprot/A0A2K5WS22 ^@ Similarity ^@ Belongs to the CARF family. http://togogenome.org/gene/9541:MAP3K7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPW4|||http://purl.uniprot.org/uniprot/A0A2K5WQB4 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.|||Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Cytoplasm http://togogenome.org/gene/9541:CYP4F12 ^@ http://purl.uniprot.org/uniprot/A0A2K5UX09|||http://purl.uniprot.org/uniprot/A8CBS0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:STAC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2G2 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9541:HSD3B7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGL1 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9541:IGF2BP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||Nucleus|||P-body|||Stress granule|||filopodium|||growth cone|||lamellipodium|||perinuclear region http://togogenome.org/gene/9541:SS18L2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL77 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/9541:KEG98_p13 ^@ http://purl.uniprot.org/uniprot/C3W4Y5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 1 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ELOVL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXJ8|||http://purl.uniprot.org/uniprot/G7NUX0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family.|||Belongs to the ELO family. ELOVL1 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.|||Endoplasmic reticulum membrane|||Interacts with LASS2, TECR and HSD17B12.|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9541:GAS8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMY5|||http://purl.uniprot.org/uniprot/A0A2K5UN12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC4 family.|||flagellum axoneme http://togogenome.org/gene/9541:GALNT5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6X2|||http://purl.uniprot.org/uniprot/G7PKL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:PRPF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYM8 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). http://togogenome.org/gene/9541:ZDHHC21 ^@ http://purl.uniprot.org/uniprot/A0A8J8YKM8|||http://purl.uniprot.org/uniprot/G7PSC3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:TOP1MT ^@ http://purl.uniprot.org/uniprot/A0A2K5V966 ^@ Function|||Similarity ^@ Belongs to the type IB topoisomerase family.|||Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/9541:YIPF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0J8|||http://purl.uniprot.org/uniprot/G8F4F5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Cell membrane|||Cytoplasm|||Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9541:SFRP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXT6|||http://purl.uniprot.org/uniprot/A0A8J8YNF6 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:DRAM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMD4|||http://purl.uniprot.org/uniprot/G7NW48 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PRUNE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0F8 ^@ Similarity ^@ Belongs to the PPase class C family. Prune subfamily. http://togogenome.org/gene/9541:GTF2I ^@ http://purl.uniprot.org/uniprot/A0A2K5UWI4|||http://purl.uniprot.org/uniprot/A0A2K5UWJ7|||http://purl.uniprot.org/uniprot/A0A2K5UWK0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SLC6A17 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9541:WASHC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU23 ^@ Similarity ^@ Belongs to the strumpellin family. http://togogenome.org/gene/9541:HSBP1L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVT8 ^@ Similarity ^@ Belongs to the HSBP1 family. http://togogenome.org/gene/9541:TPD52 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVZ2|||http://purl.uniprot.org/uniprot/A0A2K5UVZ7|||http://purl.uniprot.org/uniprot/A0A2K5UWA3|||http://purl.uniprot.org/uniprot/G7PC33 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9541:LOC102126999 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIC9 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9541:RBBP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2T5|||http://purl.uniprot.org/uniprot/A0A7N9D3U8|||http://purl.uniprot.org/uniprot/Q4R6M6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:WSCD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9H8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WSCD family.|||Membrane http://togogenome.org/gene/9541:B4GALT3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XVR9|||http://purl.uniprot.org/uniprot/G7NXA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9541:MPC1 ^@ http://purl.uniprot.org/uniprot/I7GCA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:GORAB ^@ http://purl.uniprot.org/uniprot/I7GIY1 ^@ Similarity ^@ Belongs to the GORAB family. http://togogenome.org/gene/9541:CMAS ^@ http://purl.uniprot.org/uniprot/A0A2K5V476 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CMP-NeuNAc synthase family.|||Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).|||Homotetramer; the active enzyme is formed by a dimer of dimers. http://togogenome.org/gene/9541:TMEM86A ^@ http://purl.uniprot.org/uniprot/A0A7N9CDZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/9541:MRPS18B ^@ http://purl.uniprot.org/uniprot/A0A7N9CYI5|||http://purl.uniprot.org/uniprot/I7G7B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.|||Mitochondrion http://togogenome.org/gene/9541:PTEN ^@ http://purl.uniprot.org/uniprot/A0A2K5WAG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4.|||Belongs to the PTEN phosphatase protein family.|||Cytoplasm|||Nucleus|||PML body|||Postsynaptic density|||dendritic spine http://togogenome.org/gene/9541:RXFP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSE7|||http://purl.uniprot.org/uniprot/A0A2K5VSF6|||http://purl.uniprot.org/uniprot/A0A8J8XFC7 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PTPRA ^@ http://purl.uniprot.org/uniprot/A0A2K5VF85|||http://purl.uniprot.org/uniprot/A0A2K5VF90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TMEM80 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSY1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:MED9 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYT5|||http://purl.uniprot.org/uniprot/G7PTS2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 9 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9541:FMO4 ^@ http://purl.uniprot.org/uniprot/A0A023JCM0|||http://purl.uniprot.org/uniprot/A0A2K5V4S5|||http://purl.uniprot.org/uniprot/G8F2N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:TBP ^@ http://purl.uniprot.org/uniprot/G7P4B0|||http://purl.uniprot.org/uniprot/Q4R4F5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBP family.|||Binds DNA as monomer. Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Association of TBP to form either TFIID or SL1/TIF-IB appears to be mutually exclusive. Interacts with TAF1A, TAF1B and TAF1C. Interacts with TFIIB, NCOA6, DRAP1, DR1 and ELF3. Interacts with SPIB, SNAPC1, SNAPC2 and SNAPC4. Interacts with UTF1. Interacts with BRF2; this interaction promotes recruitment of BRF2 to TATA box-containing promoters. Interacts with UBTF. Interacts with GPBP1. Interacts with CITED2. Interacts with ATF7IP. Interacts with LLPH. Interacts with HSF1 (via transactivation domain). Interacts with GTF2B (via C-terminus); this interaction with promoter-bound TBP guides RNA polymerase II into the pre-initiation complex (PIC). Interacts with PAX5 (By similarity).|||General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.|||Nucleus http://togogenome.org/gene/9541:ATXN1L ^@ http://purl.uniprot.org/uniprot/A0A2K5UMV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATXN1 family.|||Nucleus http://togogenome.org/gene/9541:H1-6 ^@ http://purl.uniprot.org/uniprot/G7P2M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9541:RTN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UV72|||http://purl.uniprot.org/uniprot/A0A2K5UVG7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:SERPINB6 ^@ http://purl.uniprot.org/uniprot/Q4R3G2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the serpin family. Ov-serpin subfamily.|||Cytoplasm|||Forms a complex with the monomeric form of beta-tryptase.|||Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress. May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). http://togogenome.org/gene/9541:POU5F1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UC29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-5 subfamily.|||Nucleus http://togogenome.org/gene/9541:ARAF ^@ http://purl.uniprot.org/uniprot/A0A2K5UUE0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/9541:TERT ^@ http://purl.uniprot.org/uniprot/A0A2K5V6I8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reverse transcriptase family. Telomerase subfamily.|||Cytoplasm|||Nucleus|||PML body|||Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.|||The RNA-interacting domain 1 (RD1)/N-terminal extension (NTE) is required for interaction with the pseudoknot-template domain of each of TERC dimers. It contains anchor sites that bind primer nucleotides upstream of the RNA-DNA hybrid and is thus an essential determinant of repeat addition processivity.|||The RNA-interacting domain 2 (RD2) is essential for both interaction with the CR4-CR5 domain of TERC and for DNA synthesis.|||The primer grip sequence in the RT domain is required for telomerase activity and for stable association with short telomeric primers.|||nucleolus|||nucleoplasm|||telomere http://togogenome.org/gene/9541:ISY1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CWY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ISY1 family.|||Nucleus http://togogenome.org/gene/9541:TNPO2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSA9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:TMEM205 ^@ http://purl.uniprot.org/uniprot/A0A8J8XMN7|||http://purl.uniprot.org/uniprot/G7PZE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM205 family.|||Membrane http://togogenome.org/gene/9541:ABHD12 ^@ http://purl.uniprot.org/uniprot/A0A2K5U189|||http://purl.uniprot.org/uniprot/Q4R766 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the serine esterase family.|||Endoplasmic reticulum membrane|||Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (By similarity).|||Membrane http://togogenome.org/gene/9541:NUP62CL ^@ http://purl.uniprot.org/uniprot/Q4R4F7 ^@ Similarity ^@ Belongs to the nucleoporin NSP1/NUP62 family. http://togogenome.org/gene/9541:MCUB ^@ http://purl.uniprot.org/uniprot/I7G6N4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCU (TC 1.A.77) family.|||Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).|||Membrane|||Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:KCNH8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBB6|||http://purl.uniprot.org/uniprot/G7NY23 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/9541:DCP1A ^@ http://purl.uniprot.org/uniprot/A0A2K5WI42|||http://purl.uniprot.org/uniprot/G7NZU4 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/9541:IL7 ^@ http://purl.uniprot.org/uniprot/A0A2K5W745 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-7/IL-9 family.|||Secreted http://togogenome.org/gene/9541:MKS1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y989|||http://purl.uniprot.org/uniprot/G7PUF5 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9541:LOC102121218 ^@ http://purl.uniprot.org/uniprot/A0A2K5U687 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/9541:CDH12 ^@ http://purl.uniprot.org/uniprot/A0A8J8YBU9|||http://purl.uniprot.org/uniprot/G7P7A5 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:VAMP7 ^@ http://purl.uniprot.org/uniprot/A0A7N9D129 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9541:LOC102145737 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:LOC102123677 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7N1|||http://purl.uniprot.org/uniprot/A0A2K5W7P1|||http://purl.uniprot.org/uniprot/A0A7N9DHH8|||http://purl.uniprot.org/uniprot/G7P8B7|||http://purl.uniprot.org/uniprot/I7GK05 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.|||Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. http://togogenome.org/gene/9541:ACKR1 ^@ http://purl.uniprot.org/uniprot/A0A097ZN24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.|||Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.|||Early endosome|||Membrane|||Recycling endosome http://togogenome.org/gene/9541:GNB2 ^@ http://purl.uniprot.org/uniprot/I7G5A5 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9541:MMP23B ^@ http://purl.uniprot.org/uniprot/A0A2K5X3N8 ^@ Caution|||Similarity ^@ Belongs to the peptidase M10A family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PPP1R12A ^@ http://purl.uniprot.org/uniprot/A0A2K5WH74|||http://purl.uniprot.org/uniprot/A0A2K5WH88|||http://purl.uniprot.org/uniprot/A0A2K5WH94|||http://purl.uniprot.org/uniprot/A0A2K5WHB9 ^@ Subcellular Location Annotation|||Subunit ^@ PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.|||stress fiber http://togogenome.org/gene/9541:AKR1C4 ^@ http://purl.uniprot.org/uniprot/Q95JH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aldo/keto reductase family.|||Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Liver specific enzyme that acts as NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain. Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH. Acts preferentially as a 3-alpha-hydroxysteroid dehydrogenase (HSD) with a subsidiary 3-beta-HSD activity. Catalyzes efficiently the transformation of the potent androgen 5-alpha-dihydrotestosterone (5alpha-DHT or 17beta-hydroxy-5alpha-androstan-3-one) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Catalyzes the reduction of estrone into 17beta-estradiol but with low efficiency. Metabolizes a broad spectrum of natural and synthetic therapeutic steroid and plays an important role in metabolism of androgens, estrogens, progestereone and conjugated steroids. Catalyzes the biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leading to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.|||Monomer.|||cytosol http://togogenome.org/gene/9541:MBOAT7 ^@ http://purl.uniprot.org/uniprot/I7GLL9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:FBN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWX7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fibrillin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:MYF5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XGL2|||http://purl.uniprot.org/uniprot/G7PIK2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/9541:LOC102123198 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBT4|||http://purl.uniprot.org/uniprot/Q28482 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:KIN ^@ http://purl.uniprot.org/uniprot/A0A2K5U197|||http://purl.uniprot.org/uniprot/G7PE65 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/9541:MORF4L2 ^@ http://purl.uniprot.org/uniprot/Q4R578 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the MSIN3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with MRFAP1 and RB1. May also interact with one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors (By similarity).|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones (By similarity).|||Nucleus http://togogenome.org/gene/9541:REM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W106|||http://purl.uniprot.org/uniprot/G7PGP2 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9541:LOC102137984 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHP3 ^@ Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family. http://togogenome.org/gene/9541:LOC102125224 ^@ http://purl.uniprot.org/uniprot/G7Q2M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:TMEM59 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6F6|||http://purl.uniprot.org/uniprot/Q4R8C8 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.|||Belongs to the TMEM59 family.|||Cell membrane|||Golgi apparatus membrane|||Interacts with ATG16L1 (via WD repeats).|||Late endosome membrane|||Lysosome membrane|||Membrane|||N-glycosylated.|||The ATG16L1-binding motif mediates interaction with ATG16L1 and promotes autophagy. http://togogenome.org/gene/9541:FBLN7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGC9|||http://purl.uniprot.org/uniprot/I7GLN4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:GMFB ^@ http://purl.uniprot.org/uniprot/A0A2K5W225 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/9541:MTHFS ^@ http://purl.uniprot.org/uniprot/A0A2K5V823 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/9541:CRISP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4D9|||http://purl.uniprot.org/uniprot/Q4R6A0 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:DXO ^@ http://purl.uniprot.org/uniprot/A0A2K5VYM7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DXO/Dom3Z family.|||Binds 2 magnesium ions.|||Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.|||Nucleus http://togogenome.org/gene/9541:DPYSL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCM5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1.|||Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. http://togogenome.org/gene/9541:CFAP52 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4I6|||http://purl.uniprot.org/uniprot/Q95JL5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CFAP52 family.|||Cytoplasm|||Interacts with BRCA2 (By similarity). Interacts with the CCT chaperonin complex (By similarity). Interacts with HSP70 (By similarity). Interacts with AK8 (By similarity). Interacts with CFAP45 (By similarity). Interacts with DNAI1 (By similarity). Interacts with IQDC (By similarity).|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). Important for proper ciliary and flagellar beating. May act in cooperation with CFAP45 and axonemal dynein subunit DNAH11. May play a role in cell growth and/or survival (By similarity).|||cilium axoneme|||flagellum http://togogenome.org/gene/9541:KRT36 ^@ http://purl.uniprot.org/uniprot/A0A2K5WK83|||http://purl.uniprot.org/uniprot/G7PUS2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:PAX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMA3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:BAAT ^@ http://purl.uniprot.org/uniprot/A0A2K5U9Z4 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9541:LOC102134224 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CFI ^@ http://purl.uniprot.org/uniprot/Q4R955 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:DAXX ^@ http://purl.uniprot.org/uniprot/A0A2K5WNJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAXX family.|||Cytoplasm|||PML body|||centromere|||nucleolus|||nucleoplasm http://togogenome.org/gene/9541:LIN28B ^@ http://purl.uniprot.org/uniprot/A0A7N9D0G7|||http://purl.uniprot.org/uniprot/A0A7N9ICH2|||http://purl.uniprot.org/uniprot/A0A7N9ICV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-28 family.|||nucleolus http://togogenome.org/gene/9541:IL2RB ^@ http://purl.uniprot.org/uniprot/Q38J85 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Cell membrane|||Cell surface|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation (By similarity).|||Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity).|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation. http://togogenome.org/gene/9541:FPR1 ^@ http://purl.uniprot.org/uniprot/G7PYI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:RNF182 ^@ http://purl.uniprot.org/uniprot/A0A8J8YJU3|||http://purl.uniprot.org/uniprot/G7P4G4 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with ATP6V0C.|||Membrane http://togogenome.org/gene/9541:CCNH ^@ http://purl.uniprot.org/uniprot/A0A2K5UEC9|||http://purl.uniprot.org/uniprot/G7P7X0|||http://purl.uniprot.org/uniprot/Q4R7U4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor (By similarity).|||Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.|||Belongs to the cyclin family.|||Belongs to the cyclin family. Cyclin C subfamily.|||Nucleus|||Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle (By similarity).|||Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. http://togogenome.org/gene/9541:SMG8 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4H0|||http://purl.uniprot.org/uniprot/G7PUG9 ^@ Function|||Similarity ^@ Belongs to the SMG8 family.|||Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. http://togogenome.org/gene/9541:METTL3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XLF4|||http://purl.uniprot.org/uniprot/G7P9P3 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/9541:PGR ^@ http://purl.uniprot.org/uniprot/G0ZT45 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Cytoplasm|||Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and represses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2-MAPK. Interacts with PRMT2. Interacts with NCOA2 and NCOA1. Interacts with KLF9. Interacts with GTF2B.|||Nucleus|||Steroid hormone receptor involved in the regulation of eukaryotic gene expression which affects cellular proliferation and differentiation in target tissues.|||The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. http://togogenome.org/gene/9541:HKDC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMC0 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9541:BLOC1S6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4D3 ^@ Function|||Similarity ^@ Belongs to the BLOC1S6 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. http://togogenome.org/gene/9541:CACHD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIQ0 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/9541:LOC102144311 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYQ8 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/9541:FTSJ1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WA84|||http://purl.uniprot.org/uniprot/I7GH29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.|||Cytoplasm|||Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. http://togogenome.org/gene/9541:THEMIS ^@ http://purl.uniprot.org/uniprot/A0A2K5VDF6 ^@ Similarity ^@ Belongs to the themis family. http://togogenome.org/gene/9541:SLAIN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6E7|||http://purl.uniprot.org/uniprot/A0A2K5W6F3|||http://purl.uniprot.org/uniprot/A0A2K5W6G8|||http://purl.uniprot.org/uniprot/G7PVJ6 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/9541:MARK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVC1|||http://purl.uniprot.org/uniprot/A0A2K5TVG8|||http://purl.uniprot.org/uniprot/A0A2K5TVI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9541:NUBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7I4|||http://purl.uniprot.org/uniprot/A0A2K5X7Y1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Cell projection|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. http://togogenome.org/gene/9541:CDK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3E5|||http://purl.uniprot.org/uniprot/Q4R6Z7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:TOB1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTF8|||http://purl.uniprot.org/uniprot/G7PUB7 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9541:NAF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAF1 family.|||Nucleus http://togogenome.org/gene/9541:LOC101866649 ^@ http://purl.uniprot.org/uniprot/A0A2K5VA12 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:HSD17B11 ^@ http://purl.uniprot.org/uniprot/Q4JK73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.|||Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione (By similarity).|||Endoplasmic reticulum|||Lipid droplet http://togogenome.org/gene/9541:SCNM1 ^@ http://purl.uniprot.org/uniprot/G8F2C2|||http://purl.uniprot.org/uniprot/I7G9L4 ^@ Function|||Subcellular Location Annotation ^@ Nucleus speckle|||Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.|||nucleoplasm http://togogenome.org/gene/9541:COQ6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UbiH/COQ6 family.|||Cell projection|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.|||FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.|||Golgi apparatus|||Mitochondrion inner membrane http://togogenome.org/gene/9541:LOC102117123 ^@ http://purl.uniprot.org/uniprot/A0A2K5WK11 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/9541:CUEDC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUEDC2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:NREP ^@ http://purl.uniprot.org/uniprot/Q4R541 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with the latency-associated peptides (LAP) of TGFB1 and TGFB2; the interaction results in a decrease in TGFB autoinduction. Interacts with FLNA.|||May have roles in neural function and cellular differentiation. Ectopic expression promotes axonal regeneration, induces differentiation of fibroblast into myofibroblast, induces myofibroblast ameboid migration, augments motility of gliomas, and increases retinoic-acid regulation of lipid-droplet biogenesis. Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3. May play a role in the regulation of alveolar generation.|||Phosphorylated on Ser-59. Phosphorylation decreases stability and activity. http://togogenome.org/gene/9541:CLRN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9541:NEMF ^@ http://purl.uniprot.org/uniprot/A0A2K5UCQ5|||http://purl.uniprot.org/uniprot/G7PA77 ^@ Similarity ^@ Belongs to the NEMF family. http://togogenome.org/gene/9541:GNAO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3X8|||http://purl.uniprot.org/uniprot/A0A2K5V415 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9541:CYP3A5 ^@ http://purl.uniprot.org/uniprot/A8CBR0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:SLC25A27 ^@ http://purl.uniprot.org/uniprot/A0A7N9D3Z0|||http://purl.uniprot.org/uniprot/A0A8J8YFY2|||http://purl.uniprot.org/uniprot/G7P4S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:CDH10 ^@ http://purl.uniprot.org/uniprot/A0A8J8XCU9|||http://purl.uniprot.org/uniprot/G7P7A7 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:WNK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTA2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/9541:CENPX ^@ http://purl.uniprot.org/uniprot/A0A2K5W525 ^@ Similarity ^@ Belongs to the CENP-X/MHF2 family. http://togogenome.org/gene/9541:HTR3B ^@ http://purl.uniprot.org/uniprot/A0A2K5TX32 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SLC39A6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WH46 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ACTA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYP0 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:SETD6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8Q3|||http://purl.uniprot.org/uniprot/A0A7N9D0A5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.|||Nucleus|||Protein-lysine N-methyltransferase. http://togogenome.org/gene/9541:GLCE ^@ http://purl.uniprot.org/uniprot/A0A8J8Y221|||http://purl.uniprot.org/uniprot/G7P900 ^@ Similarity ^@ Belongs to the D-glucuronyl C5-epimerase family. http://togogenome.org/gene/9541:LOC102122546 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRN2|||http://purl.uniprot.org/uniprot/G7P7L6 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/9541:NR2E3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBL6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102138325 ^@ http://purl.uniprot.org/uniprot/A0A0R8GGL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/9541:SV2C ^@ http://purl.uniprot.org/uniprot/A0A2K5U5S4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9541:STARD13 ^@ http://purl.uniprot.org/uniprot/A0A2K5VN99|||http://purl.uniprot.org/uniprot/A0A2K5VNE6|||http://purl.uniprot.org/uniprot/A0A7N9ID98 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:MMAB ^@ http://purl.uniprot.org/uniprot/A0A2K5U5Z3 ^@ Similarity ^@ Belongs to the Cob(I)alamin adenosyltransferase family. http://togogenome.org/gene/9541:CYP2R1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ19|||http://purl.uniprot.org/uniprot/G7PQN4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:CDR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHW2 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/9541:SHKBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KCTD3 family.|||Cell membrane http://togogenome.org/gene/9541:AKR1B1 ^@ http://purl.uniprot.org/uniprot/I7G297 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family.|||Monomer. http://togogenome.org/gene/9541:TOMM7 ^@ http://purl.uniprot.org/uniprot/A0A7N9D4I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom7 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:MAP3K14 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Cytoplasm|||Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. http://togogenome.org/gene/9541:UBA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3U5 ^@ Subcellular Location Annotation|||Subunit ^@ Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.|||Nucleus http://togogenome.org/gene/9541:PGAP6 ^@ http://purl.uniprot.org/uniprot/G7Q025 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:GRM8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOXL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWM8|||http://purl.uniprot.org/uniprot/G7PCW1 ^@ Caution|||Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Contains 1 lysine tyrosylquinone.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9541:ANKS1B ^@ http://purl.uniprot.org/uniprot/A0A2K5V4T2|||http://purl.uniprot.org/uniprot/I7G3R7|||http://purl.uniprot.org/uniprot/Q4R4X1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:FUCA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNV8|||http://purl.uniprot.org/uniprot/A0A7N9CHN9 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/9541:MAT1A ^@ http://purl.uniprot.org/uniprot/A0A2K5WMF0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/9541:UBA6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U757 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9541:COPS2 ^@ http://purl.uniprot.org/uniprot/Q4R5D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:TNFRSF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJH8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:GSDMD ^@ http://purl.uniprot.org/uniprot/A0A2K5TZY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:RBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXD8 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:SLC25A22 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:BPGM ^@ http://purl.uniprot.org/uniprot/Q4R6L7 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ At alkaline pH BPGM favors the synthase reaction; however, at lower pH the phosphatase reaction is dominant. Inhibited by citrate.|||Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.|||Homodimer.|||Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. http://togogenome.org/gene/9541:POU2F1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6C1|||http://purl.uniprot.org/uniprot/A0A2K5W6C9|||http://purl.uniprot.org/uniprot/A0A8J8XNY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-2 subfamily.|||Nucleus|||Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. http://togogenome.org/gene/9541:GNA13 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVH0|||http://purl.uniprot.org/uniprot/A0A7N9CMF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-alpha family. G(12) subfamily.|||Membrane http://togogenome.org/gene/9541:TOM1L1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YAH0|||http://purl.uniprot.org/uniprot/G7PUC6 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9541:LOC102130617 ^@ http://purl.uniprot.org/uniprot/A0A2K5WX78|||http://purl.uniprot.org/uniprot/A0A8J8XVQ5 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||Component of the 40S ribosomal subunit. http://togogenome.org/gene/9541:AARS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1E1 ^@ Caution|||Cofactor|||Domain|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||ISGylated.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/9541:MAN2B2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGT1 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9541:ZNRF4 ^@ http://purl.uniprot.org/uniprot/Q4R6Y5 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ E3 ubiquitin-protein ligase that acts as a negative regulator of NOD2 signaling by mediating ubiquitination and degradation of RIPK2. Also catalyzes ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (By similarity). Could have a role in spermatogenesis (By similarity).|||Endoplasmic reticulum membrane|||Interacts with CANX.|||The RING-type zinc finger is involved in CANX ubiquitination and degradation, but is not required for interaction with CANX. http://togogenome.org/gene/9541:RIPOR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WG45 ^@ Similarity ^@ Belongs to the RIPOR family. http://togogenome.org/gene/9541:VNN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGG4 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9541:ASPM ^@ http://purl.uniprot.org/uniprot/A0A2K5VND1|||http://purl.uniprot.org/uniprot/P62291 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).|||spindle http://togogenome.org/gene/9541:CCDC22 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAF8 ^@ Similarity ^@ Belongs to the CCDC22 family. http://togogenome.org/gene/9541:PACSIN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PACSIN family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||cytosol|||ruffle membrane|||synaptosome http://togogenome.org/gene/9541:CIAO3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WU13 ^@ Similarity ^@ Belongs to the NARF family. http://togogenome.org/gene/9541:F10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHK1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:NFKBIZ ^@ http://purl.uniprot.org/uniprot/A0A2K5W2N8 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/9541:NEK6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIU2|||http://purl.uniprot.org/uniprot/A0A2K5VIW9|||http://purl.uniprot.org/uniprot/A0A2K5VJ10 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:ALDH1B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHE5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9541:SCGB2A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYL7 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:RPL35 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJW4|||http://purl.uniprot.org/uniprot/G7PRG4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/9541:QSOX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZ16 ^@ Function|||Similarity ^@ Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.|||Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. http://togogenome.org/gene/9541:EZR ^@ http://purl.uniprot.org/uniprot/A0A2K5W6F0 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9541:LOC102123765 ^@ http://purl.uniprot.org/uniprot/A0A8J8XHR3|||http://purl.uniprot.org/uniprot/G7PWP2 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9541:SFT2D2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W553 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/9541:PPP1R15B ^@ http://purl.uniprot.org/uniprot/A0A8J8XZ24|||http://purl.uniprot.org/uniprot/G7NVE1 ^@ Similarity ^@ Belongs to the PPP1R15 family. http://togogenome.org/gene/9541:CEP76 ^@ http://purl.uniprot.org/uniprot/A0A2K5VU77|||http://purl.uniprot.org/uniprot/Q4R7Z8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP76 family.|||Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.|||centriole http://togogenome.org/gene/9541:LOC102131329 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5Z9|||http://purl.uniprot.org/uniprot/G7PV45 ^@ Similarity ^@ Belongs to the TACO1 family. http://togogenome.org/gene/9541:NEURL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5N2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:CRBN ^@ http://purl.uniprot.org/uniprot/A0A8J8XQ62|||http://purl.uniprot.org/uniprot/G7NYW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRBN family.|||Nucleus http://togogenome.org/gene/9541:ALB ^@ http://purl.uniprot.org/uniprot/A2V9Z4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the ALB/AFP/VDB family.|||Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).|||Interacts with FCGRT; this interaction regulates ALB homeostasis (By similarity). Interacts with TASOR (By similarity). In plasma, occurs in a covalently-linked complex with chromophore-bound alpha-1-microglobulin; this interaction does not prevent fatty acid binding to ALB.|||Phosphorylated by FAM20C in the extracellular medium.|||Plasma.|||Secreted http://togogenome.org/gene/9541:XKR6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9541:WDR48 ^@ http://purl.uniprot.org/uniprot/A0A2K5VW67|||http://purl.uniprot.org/uniprot/A0A2K5VWB3|||http://purl.uniprot.org/uniprot/G7NYJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR48 family.|||Endosome|||Late endosome http://togogenome.org/gene/9541:MGA ^@ http://purl.uniprot.org/uniprot/A0A2K5WI01|||http://purl.uniprot.org/uniprot/A0A2K5WIA4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:PAGE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVI5 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9541:RAB9B ^@ http://purl.uniprot.org/uniprot/A0A8J8YIR9|||http://purl.uniprot.org/uniprot/G7Q3C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/9541:SLC6A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDQ3|||http://purl.uniprot.org/uniprot/G7NYT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9541:BEST4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bestrophin family.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9541:DEFB126 ^@ http://purl.uniprot.org/uniprot/Q9BEE3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the beta-defensin family.|||High-level and epididymis-specific expression. Detected in epithelial cells lining the efferent ductules, initial segment, and cauda regions of the epididymis, but not on spermatozoa.|||Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx (PubMed:16079310, PubMed:18658160). Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte (PubMed:15349845, PubMed:18003946). In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation (By similarity).|||Homodimer or homooligomer; disulfide-linked.|||O-glycosylated; glycans contain sialic acids alpha(2,3)-linked to galactose and N-acetylgalactosamine. The C-terminal O-glycosylation contributes substantially to the sperm glyocalyx.|||Secreted http://togogenome.org/gene/9541:LOC102134935 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGF4|||http://purl.uniprot.org/uniprot/A0A2K5VGH4 ^@ Subcellular Location Annotation ^@ Cell membrane|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/9541:MFAP3L ^@ http://purl.uniprot.org/uniprot/A0A2K5WZI0|||http://purl.uniprot.org/uniprot/Q4R469 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:CMBL ^@ http://purl.uniprot.org/uniprot/A0A8J8YI23|||http://purl.uniprot.org/uniprot/G7P784 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/9541:TMC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VV08|||http://purl.uniprot.org/uniprot/A0A2K5VV82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/9541:LOC102132156 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAC5 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse|||axon|||dendrite http://togogenome.org/gene/9541:KIAA1191 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4M7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P33MONOX family.|||Cytoplasm|||Interacts with NELFB, NOL12 and PRNP.|||Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth. http://togogenome.org/gene/9541:MINPP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3B4 ^@ Similarity ^@ Belongs to the histidine acid phosphatase family. MINPP1 subfamily. http://togogenome.org/gene/9541:PSMA6 ^@ http://purl.uniprot.org/uniprot/Q4R6D8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9541:POLA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.|||Belongs to the DNA polymerase alpha subunit B family.|||Nucleus http://togogenome.org/gene/9541:NPAS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UH98 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CCSER2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYN7|||http://purl.uniprot.org/uniprot/A0A2K5VYP3|||http://purl.uniprot.org/uniprot/A0A2K5VYQ5|||http://purl.uniprot.org/uniprot/A0A8J8XAJ5|||http://purl.uniprot.org/uniprot/G7PEW3 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/9541:DIABLO ^@ http://purl.uniprot.org/uniprot/A0A2K5W6X4|||http://purl.uniprot.org/uniprot/I7GJM7 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9541:VLDLR ^@ http://purl.uniprot.org/uniprot/A0A2K5V335|||http://purl.uniprot.org/uniprot/A0A2K5V352 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LDLR family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||clathrin-coated pit http://togogenome.org/gene/9541:FXR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TM77|||http://purl.uniprot.org/uniprot/A0A2K5TM85 ^@ Similarity ^@ Belongs to the FMR1 family. http://togogenome.org/gene/9541:BTG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJW1 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9541:DAZAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9I9|||http://purl.uniprot.org/uniprot/Q25QS5|||http://purl.uniprot.org/uniprot/Q4R5H7 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Following DNA damage, phosphorylated by HIPK2 which promotes DAZAP2 localization to the nucleus, reduces interaction of DAZAP2 with HIPK2 and SIAH1, and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent HIPK2 proteasomal degradation.|||In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1 (By similarity). In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters (By similarity). This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death (By similarity). Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes (By similarity). Plays a role in stress granule formation (By similarity).|||Interacts with SOX6. Interacts with DAZ1 and DAZL. Interacts with IL17RB. May interact with FAM168B. Interacts with INCA1. Interacts with EIF4G1 and EIF4G2 (By similarity). Interacts (via PPAY motif) with NEDD4 (via WW domains) (By similarity). Interacts with transcription factor TCF4; the interaction results in localization of DAZAP2 to the nucleus (By similarity). Interacts with transcription factors TCF7 and TCF7L1 (By similarity). Interacts with transcription factor LEF1 (By similarity). Interacts with serine/threonine-protein kinase HIPK2; the interaction results in phosphorylation of DAZAP2 which causes localization of DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent degradation of HIPK2 (By similarity). Interacts with ubiquitin ligase SIAH1; the interaction is decreased following phosphorylation of DAZAP2 by HIPK2 (By similarity). Interacts with TP53; the interaction is triggered by DNA damage (By similarity).|||Nucleus|||Nucleus speckle|||Stress granule|||Ubiquitinated by SMURF2, leading to proteasomal degradation. Ubiquitinated by NEDD4, leading to proteasomal degradation.|||nuclear body http://togogenome.org/gene/9541:HAUS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS1 family.|||spindle http://togogenome.org/gene/9541:DYNLT3 ^@ http://purl.uniprot.org/uniprot/I7GH95 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9541:CCNG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7D5|||http://purl.uniprot.org/uniprot/G7P542 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9541:SENP7 ^@ http://purl.uniprot.org/uniprot/A0A7N9CBT5|||http://purl.uniprot.org/uniprot/A0A7N9CR70|||http://purl.uniprot.org/uniprot/A0A7N9CWC6|||http://purl.uniprot.org/uniprot/A0A7N9D5A5|||http://purl.uniprot.org/uniprot/A0A7N9IGX0 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9541:SLC1A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULK0|||http://purl.uniprot.org/uniprot/A0A8J8Y7D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9541:HSD17B10 ^@ http://purl.uniprot.org/uniprot/Q4JK74 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:PSME3IP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7Z1|||http://purl.uniprot.org/uniprot/A0A7N9CIP2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SLC25A36 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:PER3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WH17 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:CARMIL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TK38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CARMIL family.|||Cytoplasm http://togogenome.org/gene/9541:HDAC7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VL53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. http://togogenome.org/gene/9541:F8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZ93 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9541:FZD3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XUY6|||http://purl.uniprot.org/uniprot/G7PCZ7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:LECT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3L4 ^@ Similarity ^@ Belongs to the LECT2/MIM-1 family. http://togogenome.org/gene/9541:RPS9 ^@ http://purl.uniprot.org/uniprot/A0A8J8YSV3|||http://purl.uniprot.org/uniprot/G7PYS4 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. http://togogenome.org/gene/9541:ANXA13 ^@ http://purl.uniprot.org/uniprot/A0A2K5UE09|||http://purl.uniprot.org/uniprot/A0A2K5UE25 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9541:SHFL ^@ http://purl.uniprot.org/uniprot/A0A2K5WVI3|||http://purl.uniprot.org/uniprot/I7GLZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SHFL family.|||Nucleus|||P-body http://togogenome.org/gene/9541:RPL38 ^@ http://purl.uniprot.org/uniprot/A0A8J8XP23|||http://purl.uniprot.org/uniprot/G7PVB2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family. http://togogenome.org/gene/9541:CLK1 ^@ http://purl.uniprot.org/uniprot/Q4R4X7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:DLK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSZ3|||http://purl.uniprot.org/uniprot/G8F4F1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:FLNA ^@ http://purl.uniprot.org/uniprot/A0A2K5VB11|||http://purl.uniprot.org/uniprot/A0A2K5VB19 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/9541:TP53 ^@ http://purl.uniprot.org/uniprot/G7PTI9|||http://purl.uniprot.org/uniprot/P56423 ^@ Cofactor|||Disease Annotation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation of Lys-382 by CREBBP enhances transcriptional activity. Acetylation of Lys-382 by EP300. Deacetylation of Lys-382 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylation by SIRT2 impairs its ability to induce transcription activation in a AKT-dependent manner. Acetylation at Lys-381 increases stability. Deacetylation at Lys-381 by SIRT6 decreases its stability, thereby regulating cell senescence.|||Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.|||Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer.|||Cytoplasm|||Endoplasmic reticulum|||Forms homodimers and homotetramers (By similarity). Binds DNA as a homotetramer. Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1. Interacts with WWOX. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity. Interacts with ARMC10, BANP, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation. Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-382) with L3MBTL1. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with AURKB, SETD2, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2. Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by cyclosporin A (CsA). Interacts with SNAI1; the interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion. Interacts with KAT6A. Interacts with UBC9. Interacts with ZNF385B; the interaction is direct. Interacts (via DNA-binding domain) with ZNF385A; the interaction is direct and enhances p53/TP53 transactivation functions on cell-cycle arrest target genes, resulting in growth arrest (By similarity). Interacts with ANKRD2. Interacts with RFFL and RNF34; involved in p53/TP53 ubiquitination. Interacts with MTA1 and COP1. Interacts with CCAR2 (via N-terminus). Interacts with MORC3. Interacts (via C-terminus) with POU4F2 (via C-terminus). Interacts (via oligomerization region) with NOP53; the interaction is direct and may prevent the MDM2-mediated proteasomal degradation of TP53. Interacts with AFG1L; mediates mitochondrial translocation of TP53. Interacts with UBD (By similarity). Interacts with TAF6 (By similarity). Interacts with C10orf90/FATS; the interaction inhibits binding of TP53 and MDM2 (By similarity). Interacts with NUPR1; interaction is stress-dependent. Forms a complex with EP300 and NUPR1; this complex binds CDKN1A promoter leading to transcriptional induction of CDKN1A (By similarity). Interacts with PRMT5 in response to DNA damage; the interaction is TTC5/STRAP dependent (By similarity). Interacts with PPP1R13L (via SH3 domain and ANK repeats); the interaction inhibits pro-apoptotic activity of p53/TP53 (By similarity). Interacts with PPP1R13B/ASPP1 and TP53BP2/ASPP2; the interactions promotes pro-apoptotic activity (By similarity). When phosphorylated at Ser-15, interacts with DDX3X and gamma-tubulin (By similarity). Interacts with KAT7/HBO1; leading to inhibit histone acetyltransferase activity of KAT7/HBO1 (By similarity). Interacts (via N-terminus) with E3 ubiquitin-protein ligase MUL1; the interaction results in ubiquitination of cytoplasmic TP53 at Lys-24 and subsequent proteasomal degradation (By similarity). Interacts with S100A4; this interaction promotes TP53 degradation (By similarity). Interacts with TTC5/STRAP; the interaction may result in increased mitochondrial-dependent apoptosis (By similarity). Interacts with NQO1; this interaction is NADH-dependent, stabilizes TP53 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome (By similarity). Interacts with DAZAP2 at TP53 target gene promoters; the interaction is triggered by DNA damage and leads to modulation of the expression of a subset of TP53 target genes, reducing DNA damage-induced cell death by limiting the expression of cell death-mediating TP53 target genes (By similarity). Interacts (via N-terminus) with ZNF768 (via zinc-finger domains); interaction might be facilitated by TP53 oligomerization state (By similarity).|||Mitochondrion matrix|||Monomethylated at Lys-372 by SETD7, leading to stabilization and increased transcriptional activation. Monomethylated at Lys-370 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity. Lys-372 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-370. Dimethylated at Lys-373 by EHMT1 and EHMT2. Monomethylated at Lys-382 by KMT5A, promoting interaction with L3MBTL1 and leading to repress transcriptional activity. Demethylation of dimethylated Lys-370 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation (By similarity). Monomethylated at Arg-333 and dimethylated at Arg-335 and Arg-337 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity (By similarity).|||Nucleus|||PML body|||Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter (By similarity). Phosphorylated on Thr-18 by VRK1, which may prevent the interaction with MDM2. Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2. Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis. Phosphorylated on Thr-55 by TAF1 which promotes MDM2-mediated TP53 degradation. Phosphorylated on Ser-33 by CDK7 in a CAK complex in response to DNA damage. Phosphorylated by HIPK1. Phosphorylated on Ser-46 by HIPK2 upon UV irradiation. Phosphorylation on Ser-46 is required for acetylation by CREBBP. Phosphorylated on Ser-392 following UV but not gamma irradiation. Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated by DYRK2 at Ser-46 in response to genotoxic stress. Phosphorylated at Ser-315 and Ser-392 by CDK2 in response to DNA-damage (By similarity). Phosphorylation at Ser-15 is required for interaction with DDX3X and gamma-tubulin (By similarity).|||Sumoylated with SUMO1. Sumoylated at Lys-386 by UBC9 (By similarity).|||Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. Ubiquitinated by MKRN1 at Lys-291 and Lys-292, which leads to proteasomal degradation. Deubiquitinated by USP10, leading to stabilize it. Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation. Ubiquitination by TOPORS induces degradation. Deubiquitination by USP7, leading to stabilize it. Ubiquitinated by COP1, which leads to proteasomal degradation. Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 (By similarity).|||Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. Ubiquitinated by MKRN1, which leads to proteasomal degradation. Deubiquitinated by USP10, leading to stabilize it. Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation. Ubiquitination by TOPORS induces degradation. Deubiquitination by USP7, leading to stabilize it. Ubiquitinated by COP1, which leads to proteasomal degradation (By similarity). Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 (By similarity). Polyubiquitinated by C10orf90/FATS, polyubiquitination is 'Lys-48'-linkage independent and non-proteolytic, leading to TP53 stabilization (By similarity). Polyubiquitinated by MUL1 at Lys-24 which leads to proteasomal degradation (By similarity).|||centrosome|||p53 is found in increased amounts in a wide variety of transformed cells. p53 is frequently mutated or inactivated in many types of cancer. http://togogenome.org/gene/9541:TACR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:YARS2 ^@ http://purl.uniprot.org/uniprot/G7PHL0 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:GPHN ^@ http://purl.uniprot.org/uniprot/A0A2K5TLW1|||http://purl.uniprot.org/uniprot/A0A2K5TLW2|||http://purl.uniprot.org/uniprot/A0A2K5TLW8|||http://purl.uniprot.org/uniprot/A0A2K5TLX8|||http://purl.uniprot.org/uniprot/A0A2K5TLY1 ^@ Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.|||In the C-terminal section; belongs to the MoeA family.|||In the N-terminal section; belongs to the MoaB/Mog family. http://togogenome.org/gene/9541:RBBP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ72 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TRAPPC6B ^@ http://purl.uniprot.org/uniprot/A0A2K5TTI8|||http://purl.uniprot.org/uniprot/G7PA50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/9541:CCNQ ^@ http://purl.uniprot.org/uniprot/A0A2K5VLU1 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin-like FAM58 subfamily. http://togogenome.org/gene/9541:POLR1F ^@ http://purl.uniprot.org/uniprot/A0A2K5VT47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA43 RNA polymerase subunit family.|||nucleolus http://togogenome.org/gene/9541:ACBD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5W041 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.|||Belongs to the ATG37 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9541:MECOM ^@ http://purl.uniprot.org/uniprot/A0A2K5V7A8|||http://purl.uniprot.org/uniprot/A0A2K5V7G1|||http://purl.uniprot.org/uniprot/A0A7N9DAM4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TSPAN15 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGL3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:FZD6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U727|||http://purl.uniprot.org/uniprot/A0A8J8YDW8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Cell surface|||Cytoplasmic vesicle membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:SLC30A7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGN7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Functions as a zinc transporter.|||Homooligomer.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:CCDC85A ^@ http://purl.uniprot.org/uniprot/A0A2K5VM01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC85 family.|||adherens junction http://togogenome.org/gene/9541:EIF4EBP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6N1 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/9541:PIK3CG ^@ http://purl.uniprot.org/uniprot/A0A2K5V7M8 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9541:PSME4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WB62|||http://purl.uniprot.org/uniprot/A0A2K5WBG2|||http://purl.uniprot.org/uniprot/A0A7N9CAX7 ^@ Similarity ^@ Belongs to the BLM10 family. http://togogenome.org/gene/9541:SLC12A9 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PDLIM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPI7 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/9541:NADSYN1 ^@ http://purl.uniprot.org/uniprot/Q4R5Y2 ^@ Function|||Similarity|||Subunit ^@ Catalyzes the final step of the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway, the ATP-dependent amidation of deamido-NAD using L-glutamine as a nitrogen source.|||Homohexamer.|||In the C-terminal section; belongs to the NAD synthetase family. http://togogenome.org/gene/9541:POC5 ^@ http://purl.uniprot.org/uniprot/Q4R8G4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the POC5 family.|||Essential for the assembly of the distal half of centrioles, required for centriole elongation.|||Hyperphosphorylated during recruitment to procentrioles in G2/M phase.|||Interacts with CETN2 and CETN3.|||centriole http://togogenome.org/gene/9541:AARS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYY1|||http://purl.uniprot.org/uniprot/A0A7N9CCE8 ^@ Cofactor|||Domain|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||ISGylated.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/9541:HTR4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEA8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:EXOG ^@ http://purl.uniprot.org/uniprot/A0A2K5U5P2|||http://purl.uniprot.org/uniprot/G7NYK1 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/9541:XKR5 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9541:LIPT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDZ3 ^@ Similarity ^@ Belongs to the LplA family. http://togogenome.org/gene/9541:LOC102145605 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9541:OSTC ^@ http://purl.uniprot.org/uniprot/A0A2K5WH47|||http://purl.uniprot.org/uniprot/A0A2K5WHC3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OSTC family.|||Component of the oligosaccharyltransferase (OST) complex.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. http://togogenome.org/gene/9541:RPS25 ^@ http://purl.uniprot.org/uniprot/I7GMF4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/9541:ING5 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8Z5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9541:U2AF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0Z7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the splicing factor SR family.|||Necessary for the splicing of pre-mRNA.|||Nucleus http://togogenome.org/gene/9541:ARPC5L ^@ http://purl.uniprot.org/uniprot/A0A2K5V8A3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.|||May be a component of the Arp2/3 complex in which it may replace ARPC5.|||May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/9541:TFB2M ^@ http://purl.uniprot.org/uniprot/I7GEV2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion http://togogenome.org/gene/9541:CLIP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIR8|||http://purl.uniprot.org/uniprot/A0A2K5VIS5|||http://purl.uniprot.org/uniprot/G7PJ82 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:LOC102137969 ^@ http://purl.uniprot.org/uniprot/Q9BEH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9541:GALNT15 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR88|||http://purl.uniprot.org/uniprot/A0A2K5TRB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:SULT2A1 ^@ http://purl.uniprot.org/uniprot/P52842 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the sulfotransferase 1 family.|||Homodimer.|||Predominanly expressed in liver. Detected also in adrenal gland and in jejunum.|||Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (PubMed:31100221). Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism (By similarity). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity).|||cytosol http://togogenome.org/gene/9541:LOC107126386 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDM1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:DZIP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WT92 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:SYPL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VY61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/9541:HOXA10 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9541:CYP2A23 ^@ http://purl.uniprot.org/uniprot/A8CBQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:PADI6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPE7|||http://purl.uniprot.org/uniprot/G7NUR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9541:KIF14 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUT5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:LOC102117828 ^@ http://purl.uniprot.org/uniprot/G7PCH4|||http://purl.uniprot.org/uniprot/Q4R5B6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDH/MDH superfamily. LDH family.|||Cytoplasm|||Homotetramer. Interacts with PTEN upstream reading frame protein MP31; the interaction leads to inhibition of mitochondrial lactate dehydrogenase activity, preventing conversion of lactate to pyruvate in mitochondria.|||Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).|||Mitochondrion inner membrane http://togogenome.org/gene/9541:SLC44A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WU73|||http://purl.uniprot.org/uniprot/G8F3W2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/9541:GRINA ^@ http://purl.uniprot.org/uniprot/A0A2K5V0H6|||http://purl.uniprot.org/uniprot/A0A7N9CYH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9541:DNAH8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR03 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/9541:ZZZ3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFG3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MTMR6 ^@ http://purl.uniprot.org/uniprot/A0A2K5V469|||http://purl.uniprot.org/uniprot/G7PVV7 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9541:CCT5 ^@ http://purl.uniprot.org/uniprot/Q4R6V2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG (By similarity). Interacts with DNAAF4 (By similarity). Interacts with DLEC1 (By similarity).|||Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.|||Cytoplasm|||Ubiquitinated by the DCX(DCAF12) complex specifically recognizes the diglutamate (Glu-Glu) at the C-terminus, leading to its degradation.|||centrosome http://togogenome.org/gene/9541:TAFA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UW67 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9541:SUMF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase-modifying factor family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9541:LSR ^@ http://purl.uniprot.org/uniprot/A0A2K5WNB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. LISCH7 family.|||Membrane|||tight junction http://togogenome.org/gene/9541:BCLAF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXE7|||http://purl.uniprot.org/uniprot/A0A2K5WXP0|||http://purl.uniprot.org/uniprot/A0A2K5WXT8|||http://purl.uniprot.org/uniprot/A0A2K5WY15|||http://purl.uniprot.org/uniprot/A0A7N9IGT3 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/9541:SLC25A34 ^@ http://purl.uniprot.org/uniprot/A0A7N9D5N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:MED6 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4D7|||http://purl.uniprot.org/uniprot/A0A7N9CST5|||http://purl.uniprot.org/uniprot/Q9GKV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 6 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9541:DYNC1LI2 ^@ http://purl.uniprot.org/uniprot/Q4R5P6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes (By similarity).|||Belongs to the dynein light intermediate chain family.|||Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1 (By similarity).|||cytoskeleton http://togogenome.org/gene/9541:ZNF408 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5N0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:STAG3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TS71 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/9541:SYNGR4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFX6|||http://purl.uniprot.org/uniprot/A0A2K5WG58|||http://purl.uniprot.org/uniprot/G8F5G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/9541:LOC102124067 ^@ http://purl.uniprot.org/uniprot/A0A8J8XNC4|||http://purl.uniprot.org/uniprot/G7PQY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ESD ^@ http://purl.uniprot.org/uniprot/A0A2K5V990 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the esterase D family.|||Cytoplasmic vesicle|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/9541:GJC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPV9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||gap junction http://togogenome.org/gene/9541:ENPP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMY4|||http://purl.uniprot.org/uniprot/G7P4R7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||Cell membrane|||Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.|||Membrane http://togogenome.org/gene/9541:OLAH ^@ http://purl.uniprot.org/uniprot/A0A2K5UY40 ^@ Similarity ^@ Belongs to the thioesterase family. http://togogenome.org/gene/9541:RPS11 ^@ http://purl.uniprot.org/uniprot/A0A158SIR2|||http://purl.uniprot.org/uniprot/P61270 ^@ PTM|||Similarity ^@ Belongs to the universal ribosomal protein uS17 family.|||Citrullinated by PADI4. http://togogenome.org/gene/9541:VTI1A ^@ http://purl.uniprot.org/uniprot/A0A2K5V402 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/9541:LOC102133357 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIW7 ^@ Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 22 family.|||Monomer. http://togogenome.org/gene/9541:SERP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VW09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAMP4 family.|||Endoplasmic reticulum membrane|||May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.|||Membrane http://togogenome.org/gene/9541:DUSP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9541:LOC102146949 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWX6 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9541:NDUFA2 ^@ http://purl.uniprot.org/uniprot/G7P1Q5|||http://purl.uniprot.org/uniprot/G7P8H1|||http://purl.uniprot.org/uniprot/Q4R5E2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:CKM ^@ http://purl.uniprot.org/uniprot/A0A2K5WCT8|||http://purl.uniprot.org/uniprot/G7PXW6 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9541:LOC102121212 ^@ http://purl.uniprot.org/uniprot/A0A2K5TL96 ^@ Similarity|||Subunit ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.|||Homodimer. http://togogenome.org/gene/9541:WASL ^@ http://purl.uniprot.org/uniprot/A0A2K5VG25 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC107130570 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQY2|||http://purl.uniprot.org/uniprot/A0A7N9D7A9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:DNAJA2 ^@ http://purl.uniprot.org/uniprot/I7GPI6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ITGA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXK0|||http://purl.uniprot.org/uniprot/G8F2Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9541:DYNLL1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y705|||http://purl.uniprot.org/uniprot/G7PJ46|||http://purl.uniprot.org/uniprot/P61273 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).|||Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.|||Belongs to the dynein light chain family.|||Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.|||Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with TXNDC17. Interacts with WWC1 and ESR1. The interaction with WWC1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2L11 isoform 1 and isoform 2. Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1. Interacts with MYZAP. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2. Interacts with ATMIN; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN. Interacts with NEK9 (not phosphorylated at 'Ser-944'). Interacts with BICD2. Interacts with BCAS1. Interacts with Bassoon/BSN (By similarity). Interacts with HDAC6 (By similarity). Interacts with TPPP (By similarity). Interacts with AMBRA1 (via TQT motifs); tethering AMBRA1 to the cytoskeleton (By similarity). Interacts with FAM83D/CHICA (via C-terminus) (By similarity). Interacts with HMMR, SPAG5/Astrin and KNSTRN/Kinastrin (By similarity). Interacts with TLK2 (By similarity).|||Mitochondrion|||Nucleus|||Phosphorylation at Ser-88 appears to control the dimer-monomer transition.|||Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.|||Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity (By similarity).|||centrosome|||cytoskeleton http://togogenome.org/gene/9541:ST7L ^@ http://purl.uniprot.org/uniprot/A0A2K5U4M1|||http://purl.uniprot.org/uniprot/A0A7N9IG89|||http://purl.uniprot.org/uniprot/G7NW64|||http://purl.uniprot.org/uniprot/Q4R346 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/9541:LOC102143010 ^@ http://purl.uniprot.org/uniprot/Q95KD6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PDE10A ^@ http://purl.uniprot.org/uniprot/A0A2K5WS86|||http://purl.uniprot.org/uniprot/A0A2K5WSA0|||http://purl.uniprot.org/uniprot/A0A2K5WSA7|||http://purl.uniprot.org/uniprot/A0A2K5WSJ7|||http://purl.uniprot.org/uniprot/A0A2K5WSM7 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:EIF3B ^@ http://purl.uniprot.org/uniprot/A0A2K5WRJ1 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit B family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2. Interacts with METTL3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.|||Cytoplasm|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation.|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||The RRM domain mediates interaction with EIF3J. http://togogenome.org/gene/9541:ALDH1A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4V1 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9541:PNOC ^@ http://purl.uniprot.org/uniprot/A0A2K5VPQ6|||http://purl.uniprot.org/uniprot/G7PCZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Secreted http://togogenome.org/gene/9541:TMOD4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WG56 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:LOC102136070 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQR4|||http://purl.uniprot.org/uniprot/Q9BE11 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPRASP family.|||Cytoplasm|||Despite its name, no basic helix-loop-helix (bHLH) domain is detected by any prediction tool.|||Homodimer.|||Nucleus|||Survival and differentiation promoting protein that plays a role in the regulation of neurosynaptogenesis. Induces phosphatase PP2A activity which results in APP dephosphorylation and inhibits BACE1-mediated processing of APP. http://togogenome.org/gene/9541:PAF1 ^@ http://purl.uniprot.org/uniprot/I7GE97 ^@ Similarity ^@ Belongs to the PAF1 family. http://togogenome.org/gene/9541:STOML1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUA5|||http://purl.uniprot.org/uniprot/G7P931 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9541:DEFB119 ^@ http://purl.uniprot.org/uniprot/A0A2K5VG20|||http://purl.uniprot.org/uniprot/A0A2K5VG64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:SRRD ^@ http://purl.uniprot.org/uniprot/A0A2K5V8Y7 ^@ Similarity ^@ Belongs to the SRR1 family. http://togogenome.org/gene/9541:LOC102141409 ^@ http://purl.uniprot.org/uniprot/A0A2K5WG65|||http://purl.uniprot.org/uniprot/A0A2K5WUP0|||http://purl.uniprot.org/uniprot/A0A2K5WV15|||http://purl.uniprot.org/uniprot/A0A7N9CCJ9 ^@ Similarity ^@ Belongs to the peptidase M17 family.|||Belongs to the syntaxin family. http://togogenome.org/gene/9541:MOGS ^@ http://purl.uniprot.org/uniprot/A0A2K5VZI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 63 family.|||Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:TYK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPR0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. http://togogenome.org/gene/9541:LOC102125774 ^@ http://purl.uniprot.org/uniprot/G7NUF9 ^@ Similarity ^@ Belongs to the cornifin (SPRR) family. http://togogenome.org/gene/9541:KMO ^@ http://purl.uniprot.org/uniprot/G7NWM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aromatic-ring hydroxylase family. KMO subfamily.|||Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.|||Mitochondrion outer membrane http://togogenome.org/gene/9541:GABRA1 ^@ http://purl.uniprot.org/uniprot/G7P6T7|||http://purl.uniprot.org/uniprot/Q4R534 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by benzodiazepines, the neuroanesthetic alphaxalone and pentobarbital (By similarity). Inhibited by the antagonist bicuculline (By similarity).|||Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Glycosylated.|||Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (By similarity). Interacts with UBQLN1 (By similarity). Interacts with TRAK1 (By similarity). Interacts with KIF21B (By similarity). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (By similarity). Interacts with LHFPL4 (By similarity). Interacts with NLGN2 (By similarity). Interacts with SHISA7; interaction leads to the regulation of GABA(A) receptor trafficking, channel deactivation kinetics and pharmacology (By similarity).|||Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (By similarity). GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The extracellular domain contributes to synaptic contact formation. http://togogenome.org/gene/9541:FABP12 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQW7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:LOC102120673 ^@ http://purl.uniprot.org/uniprot/G7PUQ5|||http://purl.uniprot.org/uniprot/G7PUQ6 ^@ Subunit ^@ Interacts with hair keratins. http://togogenome.org/gene/9541:RNFT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VR77 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PYGL ^@ http://purl.uniprot.org/uniprot/A0A2K5UD22 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/9541:CRAT ^@ http://purl.uniprot.org/uniprot/A0A2K5TZN7 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9541:GOLT1A ^@ http://purl.uniprot.org/uniprot/A0A2K5V0D0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/9541:H1-2 ^@ http://purl.uniprot.org/uniprot/G7P2L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9541:GATB ^@ http://purl.uniprot.org/uniprot/I7G9S3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9541:EXOC8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EXO84 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||growth cone|||perinuclear region http://togogenome.org/gene/9541:PRKCA ^@ http://purl.uniprot.org/uniprot/A0A2K5UKX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cell membrane|||Cytoplasm|||Membrane|||Mitochondrion membrane|||Nucleus http://togogenome.org/gene/9541:BLVRA ^@ http://purl.uniprot.org/uniprot/A0A2K5X5P8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.|||Monomer.|||Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.|||cytosol http://togogenome.org/gene/9541:GLIS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5USC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLI C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9541:LOC102136686 ^@ http://purl.uniprot.org/uniprot/E1B2U4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.|||Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.|||Microsome membrane|||Mitochondrion inner membrane|||The omega-1 hydroxylase activity is stimulated by cytochrome b5. http://togogenome.org/gene/9541:TSACC ^@ http://purl.uniprot.org/uniprot/Q4R7E8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TSACC family.|||Co-chaperone that facilitates HSP-mediated activation of TSSK6.|||Interacts with HSP70. Associates with HSP90. Interacts with TSSK6; this interaction is direct and recruits TSACC to HSP90 (By similarity). http://togogenome.org/gene/9541:LOC102146102 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6S8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:STK38 ^@ http://purl.uniprot.org/uniprot/A0A8J8YLB9|||http://purl.uniprot.org/uniprot/G7P3B9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:PRORP ^@ http://purl.uniprot.org/uniprot/A0A2K5TTJ5|||http://purl.uniprot.org/uniprot/Q4R366 ^@ Cofactor|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPR family. P subfamily.|||Binds 2 Mg(2+) or Mg(2+) ions per subunit.|||Catalytic component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3.|||Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends.|||Degraded by LONP1 following mitochondrial unfolded protein response, probably leading to inhibit translation in mitochondrion.|||Displays a distorted and non-productive active site that probably switches to a fully productive state only upon association with TRMT10C/MRPP1, HSD17B10/MRPP2 and pre-tRNA substrate.|||Mitochondrion http://togogenome.org/gene/9541:DHDH ^@ http://purl.uniprot.org/uniprot/Q9TQS6 ^@ Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the Gfo/Idh/MocA family.|||Homodimer.|||Kidney. http://togogenome.org/gene/9541:LOC102127846 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMG1 ^@ Similarity ^@ Belongs to the gamma-glutamyltransferase family. http://togogenome.org/gene/9541:LOC102138899 ^@ http://purl.uniprot.org/uniprot/G7NWJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:FAXC ^@ http://purl.uniprot.org/uniprot/A0A2K5WWM2 ^@ Similarity ^@ Belongs to the FAX family. http://togogenome.org/gene/9541:HNF4G ^@ http://purl.uniprot.org/uniprot/A0A2K5V5T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:GCNT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIT0 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:ATF2 ^@ http://purl.uniprot.org/uniprot/Q4R5T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family.|||Nucleus http://togogenome.org/gene/9541:CCT2 ^@ http://purl.uniprot.org/uniprot/Q4R6F8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Interacts with FLCN (By similarity). Interacts with DLEC1 (By similarity).|||Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.|||Cytoplasm http://togogenome.org/gene/9541:KRT82 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5C3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:EIF2B1 ^@ http://purl.uniprot.org/uniprot/Q4R4V8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2B alpha/beta/delta subunits family.|||Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.|||Complex of five different subunits; alpha, beta, gamma, delta and epsilon. http://togogenome.org/gene/9541:SLC5A11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9541:DNPH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKE3|||http://purl.uniprot.org/uniprot/G8F4E6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.|||Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.|||Cytoplasm|||Monomer and homodimer.|||Nucleus http://togogenome.org/gene/9541:MMP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJN1 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9541:PRXL2A ^@ http://purl.uniprot.org/uniprot/I7G9X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.|||Cytoplasm http://togogenome.org/gene/9541:ASIC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TW12 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GATA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1K4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TMEM184A ^@ http://purl.uniprot.org/uniprot/A0A2K5X2S5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CUZD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5M7|||http://purl.uniprot.org/uniprot/G7PE97 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:SCUBE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UK84 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:GAD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1T4|||http://purl.uniprot.org/uniprot/Q2PFM7 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9541:BVES ^@ http://purl.uniprot.org/uniprot/A0A8J8Y1C4|||http://purl.uniprot.org/uniprot/G7P446 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9541:CTNND1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZL9|||http://purl.uniprot.org/uniprot/A0A2K5UZM3|||http://purl.uniprot.org/uniprot/A0A2K5UZP1|||http://purl.uniprot.org/uniprot/A0A7N9DD23|||http://purl.uniprot.org/uniprot/G7PQ26 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9541:FAM189A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4N3 ^@ Similarity ^@ Belongs to the ENTREP family. http://togogenome.org/gene/9541:UTP23 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9E8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9541:CNTNAP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX33 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:RIOK3 ^@ http://purl.uniprot.org/uniprot/Q4R6R5 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.|||Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. http://togogenome.org/gene/9541:ECHS1 ^@ http://purl.uniprot.org/uniprot/I7GL04 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9541:LYRM2 ^@ http://purl.uniprot.org/uniprot/A0A7N9IHI7 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9541:ABT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF2/ABP1 family.|||nucleolus http://togogenome.org/gene/9541:NOC3L ^@ http://purl.uniprot.org/uniprot/A0A2K5V215 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF/MAK21 family.|||nucleolus http://togogenome.org/gene/9541:KDM4C ^@ http://purl.uniprot.org/uniprot/A0A2K5WC46 ^@ Similarity ^@ Belongs to the JHDM3 histone demethylase family. http://togogenome.org/gene/9541:MICAL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDK9|||http://purl.uniprot.org/uniprot/A0A2K5WDQ5|||http://purl.uniprot.org/uniprot/A0A2K5WE02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mical family.|||Cytoplasm http://togogenome.org/gene/9541:SUMO1 ^@ http://purl.uniprot.org/uniprot/I7G9I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/9541:HSA3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZM3|||http://purl.uniprot.org/uniprot/G7PIE1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ARPC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPR8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARPC4 family.|||Cell projection|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.|||cytoskeleton http://togogenome.org/gene/9541:LOC102116103 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4B5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/9541:MKRN2 ^@ http://purl.uniprot.org/uniprot/A0A7N9DCV0|||http://purl.uniprot.org/uniprot/G7NYH0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:BBS4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYW4|||http://purl.uniprot.org/uniprot/A0A7N9D7I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BBS4 family.|||Membrane|||centrosome|||cilium membrane http://togogenome.org/gene/9541:SLC16A7 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0D2|||http://purl.uniprot.org/uniprot/G7PIX6 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:NDUFA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WX98 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:PRDX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UML5|||http://purl.uniprot.org/uniprot/I7GKK4 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9541:CFAP299 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKM9 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in spermatogenesis.|||Nucleus http://togogenome.org/gene/9541:LOC102132993 ^@ http://purl.uniprot.org/uniprot/A0A2K5V982 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:FNTB ^@ http://purl.uniprot.org/uniprot/A0A2K5WSQ5|||http://purl.uniprot.org/uniprot/A0A2K5WSS2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.|||Heterodimer of FNTA and FNTB. http://togogenome.org/gene/9541:CSF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMC4 ^@ Function|||Subunit ^@ Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.|||Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R. http://togogenome.org/gene/9541:MCM9 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9541:STK17A ^@ http://purl.uniprot.org/uniprot/A0A7N9CRA5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:MMP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5A4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M10A family.|||Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B.|||extracellular matrix http://togogenome.org/gene/9541:MTMR4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:OGFRL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UV11 ^@ Similarity ^@ Belongs to the opioid growth factor receptor family. http://togogenome.org/gene/9541:LOC102132250 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJZ0 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9541:IRF8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWD2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:LOC102140409 ^@ http://purl.uniprot.org/uniprot/A0A7N9D912 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:DTNBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W159|||http://purl.uniprot.org/uniprot/A0A2K5W171 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/9541:GABRQ ^@ http://purl.uniprot.org/uniprot/A0A2K5WU49|||http://purl.uniprot.org/uniprot/G7Q1Y1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:APOA1 ^@ http://purl.uniprot.org/uniprot/G7PP13|||http://purl.uniprot.org/uniprot/P68292 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the apolipoprotein A1/A4/E family.|||Glycosylated.|||Homodimer (By similarity). Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Interacts with SCGB3A2 (By similarity). Interacts with NAXE and YJEFN3 (By similarity).|||Major protein of plasma HDL, also found in chylomicrons.|||Palmitoylated.|||Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.|||Phosphorylation sites are present in the extracellular medium.|||Secreted http://togogenome.org/gene/9541:CTBP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/9541:LOC102144275 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3M4|||http://purl.uniprot.org/uniprot/A0A2K5V3P5|||http://purl.uniprot.org/uniprot/A0A2K5V3Q0 ^@ Similarity ^@ Belongs to the SEC2 family. http://togogenome.org/gene/9541:ONECUT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/9541:RETNLB ^@ http://purl.uniprot.org/uniprot/A0A7N9CMW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistin/FIZZ family.|||Secreted http://togogenome.org/gene/9541:TRPV4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V003 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:XK ^@ http://purl.uniprot.org/uniprot/A0A7N9CIT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9541:SMAD9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VR18|||http://purl.uniprot.org/uniprot/A0A7N9CQK0|||http://purl.uniprot.org/uniprot/A0A7N9IAG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:C14H11orf54 ^@ http://purl.uniprot.org/uniprot/A0A2K5X568|||http://purl.uniprot.org/uniprot/G7PNG8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.|||Monomer.|||Nucleus http://togogenome.org/gene/9541:CSTA ^@ http://purl.uniprot.org/uniprot/A0A8J8Y6Z8|||http://purl.uniprot.org/uniprot/G7NXR6 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/9541:ENKUR ^@ http://purl.uniprot.org/uniprot/Q4R9A6 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9541:CCR9 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVN4|||http://purl.uniprot.org/uniprot/Q0H741 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:TMEM186 ^@ http://purl.uniprot.org/uniprot/A0A2K5UP18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM186 family.|||Membrane http://togogenome.org/gene/9541:UBN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDQ1|||http://purl.uniprot.org/uniprot/A0A2K5WDY7 ^@ Similarity ^@ Belongs to the ubinuclein family. http://togogenome.org/gene/9541:SH2D1A ^@ http://purl.uniprot.org/uniprot/A0A2K5U0G4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. http://togogenome.org/gene/9541:TRABD2A ^@ http://purl.uniprot.org/uniprot/A0A2K5W0W0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TIKI family.|||Cell membrane|||Divalent metal cations. Mn(2+) or Co(2+).|||Membrane|||Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. http://togogenome.org/gene/9541:MAN2B1 ^@ http://purl.uniprot.org/uniprot/Q60HE9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit.|||Lysosome|||Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. http://togogenome.org/gene/9541:PCYT1A ^@ http://purl.uniprot.org/uniprot/A0A7N9CXD5 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/9541:STX19 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDG1 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9541:SMG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VED2 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. http://togogenome.org/gene/9541:FADS2 ^@ http://purl.uniprot.org/uniprot/G7PPX1|||http://purl.uniprot.org/uniprot/Q4R749 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Endoplasmic reticulum membrane|||Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (By similarity). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). It can also desaturate (11E)-octadecenoate (trans-vaccenoate) at carbon 6 generating (6Z,11E)-octadecadienoate (By similarity). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity).|||The protein sequence includes a number of characteristic features of microsomal fatty acid desaturases including the three histidine boxes HXXXH, HXXHH, and QXXHH (these domains may contain the active site and/or be involved in metal ion binding), and the N-terminal cytochrome b5 domain containing the heme-binding motif, HPGG, similar to that of other fatty acid desaturases. http://togogenome.org/gene/9541:TMEM98 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y645|||http://purl.uniprot.org/uniprot/G7PU17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM98 family.|||Endoplasmic reticulum membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/9541:EEF1AKMT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXZ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.|||Cytoplasm|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.|||Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure. http://togogenome.org/gene/9541:SLC1A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEU4|||http://purl.uniprot.org/uniprot/A0A2K5VEW0|||http://purl.uniprot.org/uniprot/A0A2K5VEY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9541:FAM131A ^@ http://purl.uniprot.org/uniprot/A0A2K5UM40|||http://purl.uniprot.org/uniprot/A0A7N9CK10|||http://purl.uniprot.org/uniprot/G7NYZ7 ^@ Similarity ^@ Belongs to the FAM131 family. http://togogenome.org/gene/9541:B4GALNT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WB01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family.|||Membrane http://togogenome.org/gene/9541:TIMM21 ^@ http://purl.uniprot.org/uniprot/A0A2K5UW47 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM21 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane|||Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. http://togogenome.org/gene/9541:LOC102146036 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0H2 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9541:BDKRB1 ^@ http://purl.uniprot.org/uniprot/Q3BCU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.|||Cell membrane|||This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. http://togogenome.org/gene/9541:STRIP1 ^@ http://purl.uniprot.org/uniprot/G8F3B0|||http://purl.uniprot.org/uniprot/Q9GLZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the STRIP family.|||Component of striatin-interacting phosphatase and kinase (STRIPAK) complex. Interacts with CDC42BPB. Interacts with CTTNBP2NL.|||Cytoplasm|||Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape (By similarity). http://togogenome.org/gene/9541:LOC102144820 ^@ http://purl.uniprot.org/uniprot/A0A2K5US39 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/9541:KDM3A ^@ http://purl.uniprot.org/uniprot/A0A2K5WSI1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC107127349 ^@ http://purl.uniprot.org/uniprot/A0A7N9D771 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9541:CHRNB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VK87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:MYH9 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBX7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:RNASET2 ^@ http://purl.uniprot.org/uniprot/I7GM88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase T2 family.|||Lysosome lumen http://togogenome.org/gene/9541:SLC34A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TS25 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:NAV3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM19 ^@ Similarity ^@ Belongs to the Nav/unc-53 family. http://togogenome.org/gene/9541:IGF2BP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X518 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||P-body|||Stress granule http://togogenome.org/gene/9541:RGS12 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3W4|||http://purl.uniprot.org/uniprot/A0A2K5X4E7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||dendrite http://togogenome.org/gene/9541:YBEY ^@ http://purl.uniprot.org/uniprot/A0A2K5UG22 ^@ Similarity ^@ Belongs to the endoribonuclease YbeY family. http://togogenome.org/gene/9541:ARL11 ^@ http://purl.uniprot.org/uniprot/G7PVF1 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9541:SOAT1 ^@ http://purl.uniprot.org/uniprot/Q4R775 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:LOC102131262 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:KEG98_p09 ^@ http://purl.uniprot.org/uniprot/C3W4Y9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase protein 8 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion membrane http://togogenome.org/gene/9541:DDAH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9Q6 ^@ Function|||Similarity ^@ Belongs to the DDAH family.|||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. http://togogenome.org/gene/9541:TMEM126B ^@ http://purl.uniprot.org/uniprot/A0A2K5W554|||http://purl.uniprot.org/uniprot/A0A2K5W5A8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CHD4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WA38|||http://purl.uniprot.org/uniprot/A0A2K5WAA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/9541:F9 ^@ http://purl.uniprot.org/uniprot/A0A8J8XCV8|||http://purl.uniprot.org/uniprot/G7Q1U2 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:IRF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRP3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:TNFRSF6B ^@ http://purl.uniprot.org/uniprot/A0A2K5WFD2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC102118955 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVQ6|||http://purl.uniprot.org/uniprot/A0A2K5WVV2|||http://purl.uniprot.org/uniprot/A0A2K5WVY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM231 family.|||Membrane|||Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.|||cilium membrane http://togogenome.org/gene/9541:SYPL2 ^@ http://purl.uniprot.org/uniprot/A0A7N9IEZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/9541:SERPINB7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBF3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:DNMT3A ^@ http://purl.uniprot.org/uniprot/A0A2K5UUG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.|||Nucleus http://togogenome.org/gene/9541:PON3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNZ3|||http://purl.uniprot.org/uniprot/G7P1C3 ^@ Cofactor|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit. http://togogenome.org/gene/9541:VBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZS6|||http://purl.uniprot.org/uniprot/A0A8J8XUR2|||http://purl.uniprot.org/uniprot/G7Q237 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/9541:PHF1 ^@ http://purl.uniprot.org/uniprot/G7P2T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/9541:TVP23A ^@ http://purl.uniprot.org/uniprot/A0A2K5TST6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/9541:RNGTT ^@ http://purl.uniprot.org/uniprot/A0A2K5USY0|||http://purl.uniprot.org/uniprot/A0A2K5USY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.|||In the C-terminal section; belongs to the eukaryotic GTase family.|||In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.|||Nucleus http://togogenome.org/gene/9541:RBM10 ^@ http://purl.uniprot.org/uniprot/A0A2K5V313|||http://purl.uniprot.org/uniprot/A0A2K5V322|||http://purl.uniprot.org/uniprot/G7Q2K9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ATP10B ^@ http://purl.uniprot.org/uniprot/A0A2K5VTA8|||http://purl.uniprot.org/uniprot/A0A2K5VTC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9541:SLC13A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5G4|||http://purl.uniprot.org/uniprot/G7PG32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9541:PARD6B ^@ http://purl.uniprot.org/uniprot/A0A2K5UDD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cell membrane|||Cytoplasm|||tight junction http://togogenome.org/gene/9541:SRPRB ^@ http://purl.uniprot.org/uniprot/I7GK96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP receptor beta subunit family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:ACP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSQ4 ^@ Cofactor ^@ Binds 2 iron ions per subunit. http://togogenome.org/gene/9541:VPS54 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0T5|||http://purl.uniprot.org/uniprot/A0A2K5W119|||http://purl.uniprot.org/uniprot/A0A8J8Y6W9|||http://purl.uniprot.org/uniprot/G7PMB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS54 family.|||trans-Golgi network http://togogenome.org/gene/9541:PTCH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V028 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/9541:ACTN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAL8|||http://purl.uniprot.org/uniprot/Q2PFV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alpha-actinin family.|||Cell junction|||Cell membrane|||F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).|||Homodimer; antiparallel. Interacts with MYOZ2, TTID and LPP. Interacts with DDN (By similarity). Interacts with PSD. Interacts with MICALL2 (By similarity). Interacts with DNM2 and CTTN. Interacts with PDLIM1. Interacts with PDLIM2. Interacts with PDLIM4 (via PDZ domain) (By similarity).|||Z line|||cytoskeleton|||ruffle http://togogenome.org/gene/9541:SNAPC1 ^@ http://purl.uniprot.org/uniprot/Q4R6W9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Nucleus|||Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC1 interacts with SNAPC3, SNAPC4 and TBP (By similarity).|||Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity). http://togogenome.org/gene/9541:PPTC7 ^@ http://purl.uniprot.org/uniprot/A0A7N9D6U1 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9541:SAMD4B ^@ http://purl.uniprot.org/uniprot/A0A8J8YSU4|||http://purl.uniprot.org/uniprot/G7PXJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMAUG family.|||Cytoplasm http://togogenome.org/gene/9541:EIF2A ^@ http://purl.uniprot.org/uniprot/A0A8J8Y686|||http://purl.uniprot.org/uniprot/G7NZM4 ^@ Function|||Similarity ^@ Belongs to the WD repeat EIF2A family.|||Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. http://togogenome.org/gene/9541:LOC102130734 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9541:SNX13 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2F3 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9541:RHBDL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V670 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.|||Membrane http://togogenome.org/gene/9541:ARL4D ^@ http://purl.uniprot.org/uniprot/A0A2K5UN88 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9541:NRCAM ^@ http://purl.uniprot.org/uniprot/A0A2K5VLU8|||http://purl.uniprot.org/uniprot/A0A2K5VLY7|||http://purl.uniprot.org/uniprot/A0A2K5VLZ3|||http://purl.uniprot.org/uniprot/A0A2K5VM38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.|||Membrane http://togogenome.org/gene/9541:PCLAF ^@ http://purl.uniprot.org/uniprot/A0A2K5X752|||http://purl.uniprot.org/uniprot/A0A2K5X765 ^@ Subcellular Location Annotation ^@ Nucleus|||perinuclear region http://togogenome.org/gene/9541:NMI ^@ http://purl.uniprot.org/uniprot/A0A2K5VU13|||http://purl.uniprot.org/uniprot/G7PKK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NMI family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9541:LOC102118330 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQP4|||http://purl.uniprot.org/uniprot/G7P2L5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:SEC11A ^@ http://purl.uniprot.org/uniprot/A0A2K5TS20|||http://purl.uniprot.org/uniprot/A0A2K5TS29|||http://purl.uniprot.org/uniprot/A0A2K5TS41 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:CAPN11 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3S1 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9541:SOD1 ^@ http://purl.uniprot.org/uniprot/Q8HXQ1 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems.|||Homodimer.|||Nucleus|||Palmitoylation helps nuclear targeting and decreases catalytic activity.|||Succinylation, adjacent to copper catalytic site, probably inhibits activity. Desuccinylation by SIRT5 enhances activity. http://togogenome.org/gene/9541:TMEM115 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPV1|||http://purl.uniprot.org/uniprot/G7NZZ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ALDH1L1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YFN1|||http://purl.uniprot.org/uniprot/G7NYF0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.|||In the N-terminal section; belongs to the GART family. http://togogenome.org/gene/9541:EZH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1N6|||http://purl.uniprot.org/uniprot/A0A2K5X1R4|||http://purl.uniprot.org/uniprot/Q4R381 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.|||Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2 (By similarity). The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12 (By similarity). The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit (By similarity). Interacts with HDAC1 and HDAC2 (By similarity). Binds ATRX via the SET domain (Probable). Interacts with PRAME (By similarity). Interacts with CDYL. Interacts with BMAL1, CLOCK and CRY1 (By similarity). Interacts with DNMT3L; the interaction is direct (By similarity). Interacts with EZHIP; the interaction blocks EZH2 methyltransferase activity (By similarity). Interacts with ZNF263; recruited to the SIX3 promoter along with other proteins involved in chromatin modification and transcriptional corepression where it contributes to transcriptional repression (By similarity). Interacts with ARMC12 (By similarity).|||Glycosylated: O-GlcNAcylation at Ser-75 by OGT increases stability of EZH2 and facilitates the formation of H3K27me3 by the PRC2/EED-EZH2 complex.|||Nucleus|||Phosphorylated by AKT1. Phosphorylation by AKT1 reduces methyltransferase activity. Phosphorylation at Thr-345 by CDK1 and CDK2 promotes maintenance of H3K27me3 levels at EZH2-target loci, thus leading to epigenetic gene silencing.|||Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the CLOCK-BMAL1 transcriptional activation of PER1/2. Involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription.|||Sumoylated. http://togogenome.org/gene/9541:TLR5 ^@ http://purl.uniprot.org/uniprot/B3Y638 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9541:MYSM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U142 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. MYSM1 subfamily.|||Nucleus http://togogenome.org/gene/9541:RMND1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WH78 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/9541:HIBADH ^@ http://purl.uniprot.org/uniprot/I7GH01 ^@ Similarity ^@ Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily. http://togogenome.org/gene/9541:REEP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/9541:PSMB6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQT6|||http://purl.uniprot.org/uniprot/I7G9P5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:CSNK1G3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYA5|||http://purl.uniprot.org/uniprot/A0A2K5UYF3|||http://purl.uniprot.org/uniprot/A0A2K5UYF8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/9541:NR3C2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U374 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MOGAT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLH9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:GLB1L ^@ http://purl.uniprot.org/uniprot/G7PK43|||http://purl.uniprot.org/uniprot/Q95LV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 35 family.|||Probable glycosyl hydrolase.|||Secreted http://togogenome.org/gene/9541:EMP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5C5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Probably involved in cell proliferation and cell-cell interactions. http://togogenome.org/gene/9541:MOGAT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V109|||http://purl.uniprot.org/uniprot/G7PN99 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC102133588 ^@ http://purl.uniprot.org/uniprot/A0A7N9D0H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PPT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UI31|||http://purl.uniprot.org/uniprot/A0A2K5UI60|||http://purl.uniprot.org/uniprot/A0A2K5UI68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the palmitoyl-protein thioesterase family.|||Lysosome http://togogenome.org/gene/9541:DDX4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0H6|||http://purl.uniprot.org/uniprot/A0A2K5X0I2|||http://purl.uniprot.org/uniprot/Q4R5S7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle. Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs.|||Belongs to the DEAD box helicase family.|||Belongs to the DEAD box helicase family. DDX4/VASA subfamily.|||Cytoplasm|||Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Interacts with RANBP9. Interacts with RANBP10. Interacts with PIWIL2 and MAEL. Interacts with BMAL1 and CLOCK. Interacts with Tex19.1 and, probably, Tex19.2.|||perinuclear region http://togogenome.org/gene/9541:AP4B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UI36|||http://purl.uniprot.org/uniprot/A0A7N9DG61 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9541:MIER3 ^@ http://purl.uniprot.org/uniprot/Q4R3R9 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcriptional repressor. http://togogenome.org/gene/9541:PATZ1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ16|||http://purl.uniprot.org/uniprot/A0A2K5TJ21|||http://purl.uniprot.org/uniprot/A0A2K5TJ22 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SLC30A8 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Cell membrane|||Membrane|||secretory vesicle membrane http://togogenome.org/gene/9541:DCLK3 ^@ http://purl.uniprot.org/uniprot/G7NYL8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9541:CHPF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQU6|||http://purl.uniprot.org/uniprot/A0A2K5WQY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9541:EED ^@ http://purl.uniprot.org/uniprot/A0A2K5VTW4|||http://purl.uniprot.org/uniprot/A0A8J8YAI1|||http://purl.uniprot.org/uniprot/G7PND9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ESC family.|||Nucleus http://togogenome.org/gene/9541:ERLEC1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CHS5|||http://purl.uniprot.org/uniprot/A0A8J8YBT2|||http://purl.uniprot.org/uniprot/G7PM73 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum lumen http://togogenome.org/gene/9541:MTMR9 ^@ http://purl.uniprot.org/uniprot/Q4R738 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9541:HYAL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W786|||http://purl.uniprot.org/uniprot/G7NXS8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9541:PANK4 ^@ http://purl.uniprot.org/uniprot/Q4R4U1 ^@ Activity Regulation|||Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activity is strongly promoted by Co(2+), Ni(2+), Mg(2+) and Mn(2+). Activity is inhibited by EDTA.|||Cytoplasm|||Despite belonging to the type II pantothenate kinase family, the pantothenate kinase domain contains a Val residue at position 147 and a Trp residue at position 211 instead of the two conserved active site residues, Glu and Arg. Lacks pantothenate kinase activity.|||Homodimer. Interacts with PKM.|||In the C-terminal section; belongs to the damage-control phosphatase family. Phosphopantetheine phosphatase II subfamily.|||In the N-terminal section; belongs to the type II pantothenate kinase family.|||Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels.|||Subfamily II proteins have an EGMGR motif about 50 residues from the C-terminus (By similarity). This motif lies near the metal-binding residues in the putative substrate-binding cleft 2 (By similarity). Subfamily II proteins occur only in eukaryotes, in two forms: as a stand-alone unit in plants, and as a C-terminal domain of pantothenate kinases in plants, animals, and chytrid fungi (By similarity). http://togogenome.org/gene/9541:TMEM41A ^@ http://purl.uniprot.org/uniprot/A0A2K5WJR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/9541:UFM1 ^@ http://purl.uniprot.org/uniprot/Q4R4I2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UFM1 family.|||Cytoplasm|||Interacts with UBA5. Interacts with UFC1.|||Nucleus|||Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. Ufmylation of TRIP4 regulates nuclear receptors-mediated transcription. http://togogenome.org/gene/9541:RPL13 ^@ http://purl.uniprot.org/uniprot/A0A2K5UL98 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/9541:SRP72 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP72 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).|||Cytoplasm http://togogenome.org/gene/9541:ARPP19 ^@ http://purl.uniprot.org/uniprot/G7PBI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/9541:SENP8 ^@ http://purl.uniprot.org/uniprot/A0A8J8YN89|||http://purl.uniprot.org/uniprot/G7P914 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9541:TIGD4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YH83|||http://purl.uniprot.org/uniprot/G7P6F2|||http://purl.uniprot.org/uniprot/Q4R3E3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:DDX55 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLJ2 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9541:MTR ^@ http://purl.uniprot.org/uniprot/A0A2K5V0K1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin-B12 dependent methionine synthase family.|||Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.|||Cytoplasm|||Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin. http://togogenome.org/gene/9541:FAT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHC7|||http://purl.uniprot.org/uniprot/A0A2K5WHG2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:VGLL4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEN7|||http://purl.uniprot.org/uniprot/A0A2K5UEQ6 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/9541:SYF2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YSR6|||http://purl.uniprot.org/uniprot/G7NVW6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYF2 family.|||Involved in pre-mRNA splicing.|||May be part of a spliceosome complex.|||Nucleus http://togogenome.org/gene/9541:IRGC ^@ http://purl.uniprot.org/uniprot/A0A2K5UIU3 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. http://togogenome.org/gene/9541:KIF2A ^@ http://purl.uniprot.org/uniprot/A0A2K5U740|||http://purl.uniprot.org/uniprot/A0A2K5U755|||http://purl.uniprot.org/uniprot/A0A2K5U772 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:CYP1D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMH7|||http://purl.uniprot.org/uniprot/G4V3Q8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9541:CCDC47 ^@ http://purl.uniprot.org/uniprot/A0A2K5WED9|||http://purl.uniprot.org/uniprot/G7PV49 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/9541:ITGB6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ36|||http://purl.uniprot.org/uniprot/A0A2K5TZ40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Membrane http://togogenome.org/gene/9541:FGD4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZI2|||http://purl.uniprot.org/uniprot/A0A2K5UZR6|||http://purl.uniprot.org/uniprot/A0A8J8XZT4|||http://purl.uniprot.org/uniprot/G7PHK8 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:LOC101865434 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen|||Melanosome http://togogenome.org/gene/9541:EML1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFB8|||http://purl.uniprot.org/uniprot/A0A2K5VFF5|||http://purl.uniprot.org/uniprot/A0A2K5VFJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat EMAP family.|||cytoskeleton http://togogenome.org/gene/9541:TNFRSF9 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDS9|||http://purl.uniprot.org/uniprot/A9YYE7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:FURIN ^@ http://purl.uniprot.org/uniprot/A0A2K5U5X5|||http://purl.uniprot.org/uniprot/G7P9G7 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9541:SESN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDA2|||http://purl.uniprot.org/uniprot/A0A7N9D8A9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9541:DBX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3H5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SCTR ^@ http://purl.uniprot.org/uniprot/A0A2K5W7H9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TMEM50B ^@ http://purl.uniprot.org/uniprot/G8F4V1|||http://purl.uniprot.org/uniprot/Q4R670 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/9541:MX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSV3|||http://purl.uniprot.org/uniprot/A0A8J8XMP4|||http://purl.uniprot.org/uniprot/G7P083 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9541:SEMA5B ^@ http://purl.uniprot.org/uniprot/A0A2K5TZQ5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:DTD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DTD family.|||Cytoplasm http://togogenome.org/gene/9541:HNRNPA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWM9|||http://purl.uniprot.org/uniprot/I7GJM1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:NADK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXG6|||http://purl.uniprot.org/uniprot/A0A2K5WXJ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAD kinase family.|||Homodimer.|||Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.|||Mitochondrion http://togogenome.org/gene/9541:MMRN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWD9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ORC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0V5|||http://purl.uniprot.org/uniprot/G7P2E2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102136053 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3Y6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NMNAT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKW6 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9541:OTOP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PPP1R21 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0S7|||http://purl.uniprot.org/uniprot/A0A2K5V0U6 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9541:AQP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9541:LOC102130791 ^@ http://purl.uniprot.org/uniprot/A0A2K5UP75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102117736 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMG5|||http://purl.uniprot.org/uniprot/A0A2K5VMK7|||http://purl.uniprot.org/uniprot/A0A2K5VMX8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:LOC102124147 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCV1|||http://purl.uniprot.org/uniprot/A0A7N9DFH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:ADAM28 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1P7|||http://purl.uniprot.org/uniprot/A0A2K5X1W2|||http://purl.uniprot.org/uniprot/Q9XSL6 ^@ Caution|||Cofactor|||Domain|||Function|||PTM|||Subcellular Location Annotation|||Tissue Specificity ^@ Binds 1 zinc ion per subunit.|||Expressed at high levels in epididymis and at lower levels in lung.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.|||Membrane|||Pro-domain removal and maturation may be, at least in part, autocatalytic.|||The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. http://togogenome.org/gene/9541:ETNPPL ^@ http://purl.uniprot.org/uniprot/A0A2K5UWR7|||http://purl.uniprot.org/uniprot/G7P625 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9541:LGI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5R5|||http://purl.uniprot.org/uniprot/A0A2K5W5V0|||http://purl.uniprot.org/uniprot/A0A8J8YCL6|||http://purl.uniprot.org/uniprot/G7PDL1 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:AMACR ^@ http://purl.uniprot.org/uniprot/A0A2K5V1A6 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/9541:ZFP36 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAB4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/9541:TFR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UB49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:HMGCR ^@ http://purl.uniprot.org/uniprot/A0A2K5U685|||http://purl.uniprot.org/uniprot/A0A2K5U695|||http://purl.uniprot.org/uniprot/A0A7N9CZC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMG-CoA reductase family.|||Endoplasmic reticulum membrane|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9541:LOC102122186 ^@ http://purl.uniprot.org/uniprot/G7P0E5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102145938 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4K0|||http://purl.uniprot.org/uniprot/A0A2K5WHJ6 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:TOMM40L ^@ http://purl.uniprot.org/uniprot/A0A8J8XG92|||http://purl.uniprot.org/uniprot/G7NXA9|||http://purl.uniprot.org/uniprot/I7GJP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:NTMT2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5J0|||http://purl.uniprot.org/uniprot/G7P656 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/9541:GC ^@ http://purl.uniprot.org/uniprot/A0A2K5V1W9|||http://purl.uniprot.org/uniprot/G7P5M3 ^@ Function|||Subcellular Location Annotation ^@ Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.|||Secreted http://togogenome.org/gene/9541:LOC102120590 ^@ http://purl.uniprot.org/uniprot/A0A2K5VX05|||http://purl.uniprot.org/uniprot/G7Q0U3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit C family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation. http://togogenome.org/gene/9541:CD52 ^@ http://purl.uniprot.org/uniprot/P32763 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||May play a role in carrying and orienting carbohydrate, as well as having a more specific role. http://togogenome.org/gene/9541:PACC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W157|||http://purl.uniprot.org/uniprot/A0A8J8Y0N5|||http://purl.uniprot.org/uniprot/G7NUL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the proton-activated chloride channel family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CDK5RAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKY2 ^@ Similarity ^@ Belongs to the methylthiotransferase family. MiaB subfamily. http://togogenome.org/gene/9541:TPT1 ^@ http://purl.uniprot.org/uniprot/I7G286 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/9541:HSPA1L ^@ http://purl.uniprot.org/uniprot/Q4R888 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Interacts with PRKN.|||Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Positive regulator of PRKN translocation to damaged mitochondria.|||The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins. http://togogenome.org/gene/9541:LYPD6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6Y2|||http://purl.uniprot.org/uniprot/G7PKK1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:CCNE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WV62|||http://purl.uniprot.org/uniprot/A0A2K5WVM3 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin E subfamily. http://togogenome.org/gene/9541:CHRDL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1H9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:CCT4 ^@ http://purl.uniprot.org/uniprot/Q4R8J4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.|||Cytoplasm http://togogenome.org/gene/9541:PSMB1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XGD3|||http://purl.uniprot.org/uniprot/G7P4A9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:SOGA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGI9 ^@ Similarity ^@ Belongs to the SOGA family. http://togogenome.org/gene/9541:LOC102117210 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3K9|||http://purl.uniprot.org/uniprot/A0A2K5U3L6|||http://purl.uniprot.org/uniprot/A0A2K5U3S4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102134362 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAN8 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/9541:EBF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/9541:DBT ^@ http://purl.uniprot.org/uniprot/A0A2K5VT48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9541:RCAN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDR7|||http://purl.uniprot.org/uniprot/A0A2K5WDW4 ^@ Function|||Similarity ^@ Belongs to the RCAN family.|||Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. http://togogenome.org/gene/9541:LOC102130191 ^@ http://purl.uniprot.org/uniprot/A0A2K5W618 ^@ Function|||Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. http://togogenome.org/gene/9541:WEE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGS2|||http://purl.uniprot.org/uniprot/Q95JK5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.|||Binds 2 magnesium ions per subunit.|||Nucleus http://togogenome.org/gene/9541:CPNE5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2P1|||http://purl.uniprot.org/uniprot/A0A2K5X2P2|||http://purl.uniprot.org/uniprot/A0A2K5X386 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9541:PAX6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UK60|||http://purl.uniprot.org/uniprot/A0A2K5UK65|||http://purl.uniprot.org/uniprot/I7G9J6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:DAZL ^@ http://purl.uniprot.org/uniprot/Q95192 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the RRM DAZ family.|||Cytoplasm|||Homodimer and heterodimer. Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2 Multiple DAZL RRMs can bind to a single RNA containing multiple GUU triplets (By similarity).|||Nucleus|||RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity).|||Testis specific.|||The DAZ domain mediates the interaction with DAZAP1 and DAZAP2. http://togogenome.org/gene/9541:RBMXL2 ^@ http://purl.uniprot.org/uniprot/Q4R813 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:GPR37L1 ^@ http://purl.uniprot.org/uniprot/Q4R4U4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:RXFP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN45 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:INSIG1 ^@ http://purl.uniprot.org/uniprot/I7GKV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/9541:UTS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urotensin-2 family.|||Secreted http://togogenome.org/gene/9541:DMRT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKG6 ^@ Similarity ^@ Belongs to the DMRT family. http://togogenome.org/gene/9541:CTSS ^@ http://purl.uniprot.org/uniprot/A0A2K5WQL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9541:SCN4A ^@ http://purl.uniprot.org/uniprot/A0A2K5U516 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9541:ARHGEF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCY5 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Golgi apparatus|||Vesicle|||spindle|||tight junction http://togogenome.org/gene/9541:ATF7IP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYZ5|||http://purl.uniprot.org/uniprot/A0A2K5UZ39|||http://purl.uniprot.org/uniprot/A0A2K5UZ50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCAF family.|||Nucleus http://togogenome.org/gene/9541:MGAT4B ^@ http://purl.uniprot.org/uniprot/A0A2K5UN51|||http://purl.uniprot.org/uniprot/A0A2K5UN73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 54 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:TCEA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X301 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/9541:CADM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0R3|||http://purl.uniprot.org/uniprot/A0A2K5X0R4|||http://purl.uniprot.org/uniprot/A0A2K5X0R9|||http://purl.uniprot.org/uniprot/A0A2K5X176|||http://purl.uniprot.org/uniprot/A0A2K5X1D0 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9541:GIMAP7 ^@ http://purl.uniprot.org/uniprot/G7P202 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9541:EMC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WM19|||http://purl.uniprot.org/uniprot/A0A2K5WM52|||http://purl.uniprot.org/uniprot/A0A8J8YRR3|||http://purl.uniprot.org/uniprot/G7PAP1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC4 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:CLCN4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YMS8|||http://purl.uniprot.org/uniprot/G7Q273 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/9541:WNT10B ^@ http://purl.uniprot.org/uniprot/A0A2K5VIT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:STK3 ^@ http://purl.uniprot.org/uniprot/Q4R8A9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:RRP8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRH8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. RRP8 family.|||Component of the eNoSC complex.|||Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.|||nucleolus http://togogenome.org/gene/9541:NQO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZM3 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/9541:EIF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRG3|||http://purl.uniprot.org/uniprot/A0A8J8XC80|||http://purl.uniprot.org/uniprot/G7PUS6 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/9541:HIKESHI ^@ http://purl.uniprot.org/uniprot/A0A2K5V9R3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.|||Belongs to the OPI10 family.|||Cytoplasm|||Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.|||Nucleus|||cytosol http://togogenome.org/gene/9541:PDRG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWM9|||http://purl.uniprot.org/uniprot/G7PGN4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.|||Cytoplasm|||May play a role in chaperone-mediated protein folding. http://togogenome.org/gene/9541:NLRP8 ^@ http://purl.uniprot.org/uniprot/A0A2K5U636 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/9541:MED21 ^@ http://purl.uniprot.org/uniprot/G7NWG9|||http://purl.uniprot.org/uniprot/Q4R6N3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 21 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with PPARG. Interacts with THRA in a ligand-dependent fashion (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9541:PRRC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRRC1 family.|||Golgi apparatus http://togogenome.org/gene/9541:GTSF1 ^@ http://purl.uniprot.org/uniprot/Q4R8M9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0224 (FAM112) family.|||Cytoplasm|||Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells. http://togogenome.org/gene/9541:PPIA ^@ http://purl.uniprot.org/uniprot/G7PR21|||http://purl.uniprot.org/uniprot/G7PWP2 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9541:ALKBH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAK3|||http://purl.uniprot.org/uniprot/G7PI61 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9541:P4HA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9541:TGM4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2A3 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9541:BBS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5J4 ^@ Subcellular Location Annotation ^@ centriolar satellite|||cilium membrane http://togogenome.org/gene/9541:CDC14B ^@ http://purl.uniprot.org/uniprot/A0A2K5WTS3|||http://purl.uniprot.org/uniprot/A0A2K5WU03 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/9541:ACY3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WT98 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9541:CLCN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZ25|||http://purl.uniprot.org/uniprot/A0A2K5WZE6|||http://purl.uniprot.org/uniprot/A0A2K5WZE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.|||Cell membrane|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9541:SPCS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS3 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:LOC102131960 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1Z8|||http://purl.uniprot.org/uniprot/G7PUS3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:ZSCAN31 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTD8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:AK6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WX79 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.|||Cajal body|||Monomer and homodimer. Interacts with COIL (via C-terminus).|||nucleoplasm http://togogenome.org/gene/9541:NFU1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7D5 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/9541:ATL2 ^@ http://purl.uniprot.org/uniprot/Q95LN3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.|||Endoplasmic reticulum membrane|||GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis.|||Interacts with REEP5 and RTN3. Interacts with ZFYVE27. http://togogenome.org/gene/9541:ST6GALNAC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:SOSTDC1 ^@ http://purl.uniprot.org/uniprot/G7P190 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:CXCR5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WP76|||http://purl.uniprot.org/uniprot/G8F5K4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:TACR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VH04 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane http://togogenome.org/gene/9541:GALE ^@ http://purl.uniprot.org/uniprot/A0A2K5TWK3|||http://purl.uniprot.org/uniprot/A0A8J8XC21|||http://purl.uniprot.org/uniprot/Q4R651 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.|||Homodimer. http://togogenome.org/gene/9541:LOC107129595 ^@ http://purl.uniprot.org/uniprot/G7P2L9|||http://purl.uniprot.org/uniprot/G7P2N0|||http://purl.uniprot.org/uniprot/Q4R362 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.|||Belongs to the histone H4 family.|||Butyrylation of histones marks active promoters and competes with histone acetylation.|||Chromosome|||Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).|||Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.|||Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.|||Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.|||Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).|||Nucleus|||Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).|||Sumoylated, which is associated with transcriptional repression.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).|||Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. http://togogenome.org/gene/9541:ESRRA ^@ http://purl.uniprot.org/uniprot/A0A2K5VB75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9541:PROM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VE89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/9541:NAT1 ^@ http://purl.uniprot.org/uniprot/A0A4Y1K7V2 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/9541:LOC101867510 ^@ http://purl.uniprot.org/uniprot/A0A2K5V443 ^@ Similarity ^@ Belongs to the TCP10 family. http://togogenome.org/gene/9541:PNRC2 ^@ http://purl.uniprot.org/uniprot/G7NVV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PNRC family. PNRC2 subfamily.|||Nucleus|||P-body http://togogenome.org/gene/9541:NAPG ^@ http://purl.uniprot.org/uniprot/A0A2K5WRM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9541:COPA ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ52|||http://purl.uniprot.org/uniprot/G7NWD0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. http://togogenome.org/gene/9541:MAP3K11 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7B1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/9541:B3GNT4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V219 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:GTF2H3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKY2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB4 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.|||Nucleus|||Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7. http://togogenome.org/gene/9541:CARNMT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFG1 ^@ Similarity ^@ Belongs to the carnosine N-methyltransferase family. http://togogenome.org/gene/9541:DDR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V739|||http://purl.uniprot.org/uniprot/A0A2K5V742 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBX3|||http://purl.uniprot.org/uniprot/A0A2K5WC34|||http://purl.uniprot.org/uniprot/A0A2K5WC39|||http://purl.uniprot.org/uniprot/A0A2K5WC53 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9541:MED11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQT5|||http://purl.uniprot.org/uniprot/G7PT87 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 11 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9541:DUXA ^@ http://purl.uniprot.org/uniprot/A0A2K5VE58 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:HACD4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8W6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:EREG ^@ http://purl.uniprot.org/uniprot/A0A2K5UAU1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:RWDD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFK9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:LOC102118590 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/9541:PAPPA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6K1 ^@ Caution|||Similarity ^@ Belongs to the peptidase M43B family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PLIN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFJ0 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9541:SPATA21 ^@ http://purl.uniprot.org/uniprot/Q4R736 ^@ Function ^@ Involved in the differentiation of haploid spermatids. http://togogenome.org/gene/9541:LOC102145066 ^@ http://purl.uniprot.org/uniprot/G7PWP2 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9541:FABP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1P3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.|||Cytoplasm|||Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. http://togogenome.org/gene/9541:PARP6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7C7|||http://purl.uniprot.org/uniprot/A0A2K5X7T5 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9541:DDR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSW1|||http://purl.uniprot.org/uniprot/A0A2K5TSY1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:HCN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U448 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel HCN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:NR4A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEP2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family.|||Cytoplasm|||Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.|||Nucleus http://togogenome.org/gene/9541:CNTNAP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXG0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.|||Membrane http://togogenome.org/gene/9541:ATM ^@ http://purl.uniprot.org/uniprot/A0A2K5VCC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. ATM subfamily.|||Cytoplasmic vesicle|||Nucleus|||Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9, UBQLN4 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks. http://togogenome.org/gene/9541:HACL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFK0|||http://purl.uniprot.org/uniprot/G7NY13 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/9541:LOC102137297 ^@ http://purl.uniprot.org/uniprot/A0A2K5VW75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 6c family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:SCRN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U580|||http://purl.uniprot.org/uniprot/G7PU63 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/9541:NIPBL ^@ http://purl.uniprot.org/uniprot/A0A2K5VYP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCC2/Nipped-B family.|||Nucleus http://togogenome.org/gene/9541:MRPL13 ^@ http://purl.uniprot.org/uniprot/I7GIH0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/9541:KALRN ^@ http://purl.uniprot.org/uniprot/A0A2K5VIL2|||http://purl.uniprot.org/uniprot/A0A2K5VJB6|||http://purl.uniprot.org/uniprot/A0A2K5VJC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9541:S100B ^@ http://purl.uniprot.org/uniprot/A0A8J8YNZ8|||http://purl.uniprot.org/uniprot/G7PWM2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Nucleus|||Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. http://togogenome.org/gene/9541:BDNF ^@ http://purl.uniprot.org/uniprot/A0A2K5WBZ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NGF-beta family.|||During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.|||Monomers and homodimers. Binds to NTRK2/TRKB.|||Secreted http://togogenome.org/gene/9541:TMEM144 ^@ http://purl.uniprot.org/uniprot/A0A8J8XHB4|||http://purl.uniprot.org/uniprot/G7P6H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM144 family.|||Membrane http://togogenome.org/gene/9541:DNAJB14 ^@ http://purl.uniprot.org/uniprot/I7GN03 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ARRB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7G7|||http://purl.uniprot.org/uniprot/A0A2K5U7G8 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9541:ATP1A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Membrane http://togogenome.org/gene/9541:TOM1L2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1G7|||http://purl.uniprot.org/uniprot/A0A2K5U1I9 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9541:LITAF ^@ http://purl.uniprot.org/uniprot/A0A7N9IFP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9541:NGFR ^@ http://purl.uniprot.org/uniprot/A0A2K5VJS0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:CCSER1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V547|||http://purl.uniprot.org/uniprot/A0A2K5V554 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/9541:MCHR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X035|||http://purl.uniprot.org/uniprot/G7P439|||http://purl.uniprot.org/uniprot/Q8SQ54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis. http://togogenome.org/gene/9541:PGAM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V242 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9541:PHLDA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ96 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:TP63 ^@ http://purl.uniprot.org/uniprot/A0A2K5VC97|||http://purl.uniprot.org/uniprot/A0A2K5VCF3|||http://purl.uniprot.org/uniprot/A0A8J8YGJ4|||http://purl.uniprot.org/uniprot/G7NYP4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.|||Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer.|||Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:CARTPT ^@ http://purl.uniprot.org/uniprot/A0A8J8YQB8|||http://purl.uniprot.org/uniprot/G7P7P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CART family.|||Secreted http://togogenome.org/gene/9541:ZNF280C ^@ http://purl.uniprot.org/uniprot/A0A2K5VYK8 ^@ Function|||Subcellular Location Annotation ^@ May function as a transcription factor.|||Nucleus http://togogenome.org/gene/9541:CYLD ^@ http://purl.uniprot.org/uniprot/A0A2K5VGU4|||http://purl.uniprot.org/uniprot/A0A2K5VGV6|||http://purl.uniprot.org/uniprot/A0A2K5VGW8|||http://purl.uniprot.org/uniprot/A0A7N9CUC3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||centrosome|||cilium basal body|||perinuclear region|||spindle http://togogenome.org/gene/9541:CHPF ^@ http://purl.uniprot.org/uniprot/A0A2K5WWF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9541:PTGES2 ^@ http://purl.uniprot.org/uniprot/I7GJK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GST superfamily.|||Membrane http://togogenome.org/gene/9541:PLAA ^@ http://purl.uniprot.org/uniprot/I7GHC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PLAP family.|||Cytoplasm http://togogenome.org/gene/9541:CEP57L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UC13 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/9541:ADAM15 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKC2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PODXL ^@ http://purl.uniprot.org/uniprot/A0A2K5UB78|||http://purl.uniprot.org/uniprot/A0A2K5UB82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the podocalyxin family.|||Cell membrane|||Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.|||Membrane|||Membrane raft|||filopodium|||lamellipodium|||microvillus|||ruffle http://togogenome.org/gene/9541:BRAF ^@ http://purl.uniprot.org/uniprot/A0A2K5U8K6|||http://purl.uniprot.org/uniprot/A0A2K5U8L0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/9541:MRPS30 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4T2 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9541:SRSF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZ58 ^@ Similarity ^@ Belongs to the splicing factor SR family. http://togogenome.org/gene/9541:JRK ^@ http://purl.uniprot.org/uniprot/A0A2K5UBX9|||http://purl.uniprot.org/uniprot/G7PD20 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NAPB ^@ http://purl.uniprot.org/uniprot/A0A2K5UFJ6|||http://purl.uniprot.org/uniprot/I7GPF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9541:SLC1A5 ^@ http://purl.uniprot.org/uniprot/G7PXZ3|||http://purl.uniprot.org/uniprot/Q4R8W8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A5 subfamily.|||Cell membrane|||Homotrimer.|||Melanosome|||Membrane|||Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. http://togogenome.org/gene/9541:LOC102120841 ^@ http://purl.uniprot.org/uniprot/A0A2K5UK74 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/9541:WAPL ^@ http://purl.uniprot.org/uniprot/A0A2K5W3M5 ^@ Similarity ^@ Belongs to the WAPL family. http://togogenome.org/gene/9541:PTGDR ^@ http://purl.uniprot.org/uniprot/A0A8J8Y1H0|||http://purl.uniprot.org/uniprot/G7PA94 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:COPG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9541:LOC102144405 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8Y3|||http://purl.uniprot.org/uniprot/G7Q165 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9541:MMS22L ^@ http://purl.uniprot.org/uniprot/A0A2K5WBI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MMS22 family. MMS22L subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9541:FAM126B ^@ http://purl.uniprot.org/uniprot/A0A2K5V065|||http://purl.uniprot.org/uniprot/G7PL62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM126 family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9541:NHEJ1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TL24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XLF subfamily.|||Nucleus http://togogenome.org/gene/9541:AIFM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6Q3|||http://purl.uniprot.org/uniprot/A0A7N9CDH0|||http://purl.uniprot.org/uniprot/A0A8J8YM33|||http://purl.uniprot.org/uniprot/G7Q3N8 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase family. http://togogenome.org/gene/9541:ADRA1B ^@ http://purl.uniprot.org/uniprot/A0A2K5VRK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||Nucleus membrane|||This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.|||caveola http://togogenome.org/gene/9541:POLR2D ^@ http://purl.uniprot.org/uniprot/A0A2K5UYV2|||http://purl.uniprot.org/uniprot/G7PLH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9541:MTHFR ^@ http://purl.uniprot.org/uniprot/A0A158SIR4|||http://purl.uniprot.org/uniprot/A0A2K5VEN8|||http://purl.uniprot.org/uniprot/A0A2K5VER6|||http://purl.uniprot.org/uniprot/A0A7N9CEX6|||http://purl.uniprot.org/uniprot/G8F4Z9|||http://purl.uniprot.org/uniprot/Q60HE5 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subunit ^@ Allosterically regulated by S-adenosylmethionine (SAM).|||Belongs to the methylenetetrahydrofolate reductase family.|||Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Represents a key regulatory connection between the folate and methionine cycles.|||Contains a serine-rich phosphorylation region at the N-terminal and an eukaryote-only S-adenosylmethionine (SAM)-binding domain at the C-terminal. Through asymmetric homodimerization, the two regions are positioned next to each other and N-terminal phosphorylation increases sensitivity to SAM binding and inhibition.|||Homodimer.|||Phosphorylation of an N-terminal serine-rich phosphorylation region increases sensitivity to S-adenosylmethionine and inhibition. http://togogenome.org/gene/9541:PTPN6 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7T8|||http://purl.uniprot.org/uniprot/A0A2K5V7X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.|||Cytoplasm http://togogenome.org/gene/9541:SF3B6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W230 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CHD8 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6J3|||http://purl.uniprot.org/uniprot/A0A2K5U6M5|||http://purl.uniprot.org/uniprot/A0A2K5U6M9 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNF2/RAD54 helicase family.|||Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.|||DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.|||Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Sumoylated. http://togogenome.org/gene/9541:SLC7A7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRH5|||http://purl.uniprot.org/uniprot/A0A7N9CP17 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:UNG ^@ http://purl.uniprot.org/uniprot/A0A2K5X4Z5|||http://purl.uniprot.org/uniprot/Q4R4X0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.|||Mitochondrion|||Monomer. Interacts with FAM72A.|||Nucleus http://togogenome.org/gene/9541:C11H12orf43 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUSTOS family.|||Nucleus envelope http://togogenome.org/gene/9541:DUSP6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMF4 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9541:PRF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Secreted http://togogenome.org/gene/9541:CSF3R ^@ http://purl.uniprot.org/uniprot/A0A2K5V2W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9541:DNMT3B ^@ http://purl.uniprot.org/uniprot/A0A2K5X650|||http://purl.uniprot.org/uniprot/A0A2K5X689|||http://purl.uniprot.org/uniprot/A0A2K5X6A2|||http://purl.uniprot.org/uniprot/A0A2K5X6M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.|||Nucleus http://togogenome.org/gene/9541:ANO6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W607|||http://purl.uniprot.org/uniprot/A0A2K5W624|||http://purl.uniprot.org/uniprot/G7PHN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:XKRX ^@ http://purl.uniprot.org/uniprot/G7Q383 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9541:AWAT2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDP5|||http://purl.uniprot.org/uniprot/G7Q2Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:EAF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WT64 ^@ Similarity ^@ Belongs to the EAF family. http://togogenome.org/gene/9541:FADS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:ACOX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/9541:STMN2 ^@ http://purl.uniprot.org/uniprot/Q4R4Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the stathmin family.|||Cytoplasm|||Membrane|||lamellipodium http://togogenome.org/gene/9541:STC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7H0 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9541:SAMM50 ^@ http://purl.uniprot.org/uniprot/I7GH23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAM50/omp85 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9541:KIT ^@ http://purl.uniprot.org/uniprot/A0A2K5U4C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102138501 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQA7 ^@ Similarity ^@ Belongs to the GPRASP family. http://togogenome.org/gene/9541:PSMB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8G9|||http://purl.uniprot.org/uniprot/G8F2D0|||http://purl.uniprot.org/uniprot/I7G3E3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/9541:DHRS4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9M1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:TLR4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1N2|||http://purl.uniprot.org/uniprot/B3Y631 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9541:BANF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U180 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TUBE1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2S7|||http://purl.uniprot.org/uniprot/G7P3M6 ^@ Similarity ^@ Belongs to the tubulin family. http://togogenome.org/gene/9541:NDUFAF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBD3 ^@ Similarity ^@ Belongs to the complex I NDUFA12 subunit family. http://togogenome.org/gene/9541:B4GALT4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCS8|||http://purl.uniprot.org/uniprot/G7NXN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9541:NELL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAV9|||http://purl.uniprot.org/uniprot/A0A2K5VAZ1|||http://purl.uniprot.org/uniprot/A0A2K5VB01 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:GPD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UX43|||http://purl.uniprot.org/uniprot/Q4R755 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.|||Calcium-binding enhance the activity of the enzyme.|||Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.|||Mitochondrion http://togogenome.org/gene/9541:GPC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan that bears heparan sulfate.|||extracellular space http://togogenome.org/gene/9541:DNAAF8 ^@ http://purl.uniprot.org/uniprot/Q95JW1 ^@ Function|||Subcellular Location Annotation ^@ Dynein axonemal particle|||In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits. http://togogenome.org/gene/9541:TRDMT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W043 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/9541:NIPAL3 ^@ http://purl.uniprot.org/uniprot/I7GH41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9541:BEX1 ^@ http://purl.uniprot.org/uniprot/Q2PG52 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BEX family.|||Cytoplasm|||Interacts with neurotrophin receptor p75NTR/NGFR. Interacts with OMP (By similarity).|||Nucleus|||Phosphorylated. Phosphorylation of Ser-105 protects it from the proteasome (By similarity).|||Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity).|||Ubiquitinated. Degraded by the proteasome (By similarity). http://togogenome.org/gene/9541:CLEC16A ^@ http://purl.uniprot.org/uniprot/A0A2K5TX46|||http://purl.uniprot.org/uniprot/A0A2K5TX56 ^@ Similarity ^@ Belongs to the CLEC16A/gop-1 family. http://togogenome.org/gene/9541:CD6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1K4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:POU4F2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9541:TMPRSS5 ^@ http://purl.uniprot.org/uniprot/I7GML1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:IL13RA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4S7|||http://purl.uniprot.org/uniprot/A0A7N9D0M5 ^@ Similarity ^@ Belongs to the type I cytokine receptor family. Type 5 subfamily. http://togogenome.org/gene/9541:TMCO1 ^@ http://purl.uniprot.org/uniprot/G7NU31 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TMCO1 family.|||Calcium-selective channel required to prevent calcium stores from overfilling.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homodimer and homotetramer. Homodimer under resting conditions; forms homotetramers following and ER calcium overload.|||Membrane http://togogenome.org/gene/9541:MDM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLG7|||http://purl.uniprot.org/uniprot/A0A2K5VLI4|||http://purl.uniprot.org/uniprot/A0A2K5VLK3|||http://purl.uniprot.org/uniprot/A0A2K5VLM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM1 family.|||Nucleus|||centriole http://togogenome.org/gene/9541:SLC12A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U743 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9541:RNASEH2B ^@ http://purl.uniprot.org/uniprot/A0A2K5WM39 ^@ Similarity|||Subunit ^@ Belongs to the RNase H2 subunit B family.|||The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C. http://togogenome.org/gene/9541:THYN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X461 ^@ Function ^@ Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. http://togogenome.org/gene/9541:SEC24D ^@ http://purl.uniprot.org/uniprot/A0A2K5WPA4|||http://purl.uniprot.org/uniprot/A0A2K5WPA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9541:DOK4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQP8|||http://purl.uniprot.org/uniprot/G7Q182 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9541:AP2B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V576|||http://purl.uniprot.org/uniprot/A0A2K5V588 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9541:EDNRA ^@ http://purl.uniprot.org/uniprot/A0A2K5TPJ0|||http://purl.uniprot.org/uniprot/A0A8J8YQK9|||http://purl.uniprot.org/uniprot/G7P6D6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/9541:NKIRAS1 ^@ http://purl.uniprot.org/uniprot/G7NY88|||http://purl.uniprot.org/uniprot/Q9BH04 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).|||Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.|||Cytoplasm|||In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.|||Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only interacts with NFKBIB in vivo. Forms a complex with NFKBIB and NF-kappa-B heterodimer (p50/NFKB1 and p65/RELA). Also interacts with c-Rel (REL) (By similarity). http://togogenome.org/gene/9541:ATP6V1C2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V584|||http://purl.uniprot.org/uniprot/A0A2K5V5C1|||http://purl.uniprot.org/uniprot/A0A7N9CER9|||http://purl.uniprot.org/uniprot/A0A8J8XE37|||http://purl.uniprot.org/uniprot/G7PLL5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/9541:FAM124B ^@ http://purl.uniprot.org/uniprot/A0A2K5UWB2|||http://purl.uniprot.org/uniprot/G7PK71 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/9541:GRPEL1 ^@ http://purl.uniprot.org/uniprot/G7P574 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/9541:PPIL4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V405 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9541:PGAM1 ^@ http://purl.uniprot.org/uniprot/Q4R5G4 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9541:ENO2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDC7|||http://purl.uniprot.org/uniprot/A0A2K5WDD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9541:ADSS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4G6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.|||Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. http://togogenome.org/gene/9541:NCOA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUA2|||http://purl.uniprot.org/uniprot/A0A2K5WUB9|||http://purl.uniprot.org/uniprot/A0A7N9IFH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/9541:KEG98_p10 ^@ http://purl.uniprot.org/uniprot/C3W4Y8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:POLR3GL ^@ http://purl.uniprot.org/uniprot/A0A8J8YID9|||http://purl.uniprot.org/uniprot/G7NTQ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9541:HSPA4L ^@ http://purl.uniprot.org/uniprot/A0A2K5W8C5 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9541:CASTOR2 ^@ http://purl.uniprot.org/uniprot/A0A7N9IC38 ^@ Similarity ^@ Belongs to the GATS family. http://togogenome.org/gene/9541:SF3A3 ^@ http://purl.uniprot.org/uniprot/Q4R762 ^@ Similarity ^@ Belongs to the SF3A3 family. http://togogenome.org/gene/9541:CBFB ^@ http://purl.uniprot.org/uniprot/A0A2K5U834 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF-beta family.|||Nucleus http://togogenome.org/gene/9541:CYP2G2 ^@ http://purl.uniprot.org/uniprot/F2VJZ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:FOXO3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJR2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SEMA4F ^@ http://purl.uniprot.org/uniprot/A0A2K5UKU7|||http://purl.uniprot.org/uniprot/A0A2K5UKV2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:CMTR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZK3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with POLR2A (via C-terminus).|||Nucleus|||S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).|||S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. http://togogenome.org/gene/9541:CLCN2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAS7|||http://purl.uniprot.org/uniprot/G7NYZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CRB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TN44|||http://purl.uniprot.org/uniprot/A0A8J8Y5Q7|||http://purl.uniprot.org/uniprot/G7NWI2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:HSF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1B4|||http://purl.uniprot.org/uniprot/A0A2K5V1D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9541:TRAPPC1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YRK2|||http://purl.uniprot.org/uniprot/G7PTJ7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/9541:LOC102118180 ^@ http://purl.uniprot.org/uniprot/A0A7N9CWV2 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9541:AIF1L ^@ http://purl.uniprot.org/uniprot/A0A2K5X8V1 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/9541:MSRB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWU1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/9541:ELF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:CCR10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAP1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:MEGF8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIH1|||http://purl.uniprot.org/uniprot/A0A2K5VIM4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PTDSS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphatidyl serine synthase family.|||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:ATP6V1E1 ^@ http://purl.uniprot.org/uniprot/Q4R761 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the V-ATPase E subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity). Interacts with ALDOC (By similarity). Interacts with RAB11B (By similarity).|||clathrin-coated vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/9541:NRBP1 ^@ http://purl.uniprot.org/uniprot/Q4R8X0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.|||Endomembrane system|||Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm (By similarity).|||May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases.|||The protein kinase domain is predicted to be catalytically inactive.|||cell cortex|||lamellipodium http://togogenome.org/gene/9541:CANX ^@ http://purl.uniprot.org/uniprot/A0A2K5UYZ9|||http://purl.uniprot.org/uniprot/G7P728 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/9541:OVOL1 ^@ http://purl.uniprot.org/uniprot/A0A7N9IB29 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SMYD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIX8 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.|||cytosol http://togogenome.org/gene/9541:ADAM9 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4X8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:ADRB3 ^@ http://purl.uniprot.org/uniprot/U6BY27 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.|||Cell membrane|||Interacts with ARRDC3.|||Membrane http://togogenome.org/gene/9541:SHOC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRD9 ^@ Function|||Similarity ^@ Belongs to the SHOC2 family.|||Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. http://togogenome.org/gene/9541:LOC102118097 ^@ http://purl.uniprot.org/uniprot/A0A8U0WQ25|||http://purl.uniprot.org/uniprot/G8F3V0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:HIGD2A ^@ http://purl.uniprot.org/uniprot/A0A8J8Y250|||http://purl.uniprot.org/uniprot/G7P6Y9 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9541:ARF6 ^@ http://purl.uniprot.org/uniprot/G7PA78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Cell membrane|||Cleavage furrow|||Endosome membrane|||Midbody ring|||Recycling endosome membrane|||filopodium membrane|||ruffle http://togogenome.org/gene/9541:LOC102146935 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4K0|||http://purl.uniprot.org/uniprot/A0A2K5WHJ6 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:MAGOHB ^@ http://purl.uniprot.org/uniprot/A0A2K5V0C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/9541:ACOT13 ^@ http://purl.uniprot.org/uniprot/A0A2K5VB63|||http://purl.uniprot.org/uniprot/G7P4J8 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/9541:GORASP2 ^@ http://purl.uniprot.org/uniprot/G7PKT3|||http://purl.uniprot.org/uniprot/I7GH15 ^@ Similarity ^@ Belongs to the GORASP family. http://togogenome.org/gene/9541:NCAPD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYG6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the condensin-2 complex.|||Nucleus|||Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. http://togogenome.org/gene/9541:LOC101926166 ^@ http://purl.uniprot.org/uniprot/A0A2K5VI44 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/9541:GUCY2D ^@ http://purl.uniprot.org/uniprot/A0A2K5UYR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane|||Photoreceptor outer segment membrane http://togogenome.org/gene/9541:TRIM63 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYQ8|||http://purl.uniprot.org/uniprot/G8F380 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:B9D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKM2 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9541:TAF6 ^@ http://purl.uniprot.org/uniprot/A0A8J8YMH2|||http://purl.uniprot.org/uniprot/G7P0C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF6 family.|||Nucleus http://togogenome.org/gene/9541:PAGE2B ^@ http://purl.uniprot.org/uniprot/A0A2K5W4M5 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9541:RAB1B ^@ http://purl.uniprot.org/uniprot/Q4R8X3 ^@ Activity Regulation|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small GTPase superfamily. Rab family.|||Cytoplasm|||Interacts with MICAL1 and MICAL2. Interacts (in GTP-bound form) with MICALCL, MICAL1 and MILCAL3. Interacts with GDI1; the interaction requires the GDP-bound state. Interacts with CHM/REP1; the interaction requires the GDP-bound form and is necessary for prenylation by GGTase II. Interacts with RabGAP TBC1D20. Interacts (in GDP-bound form) with lipid phosphatase MTMR6 (via GRAM domain); the interaction regulates MTMR6 recruitment to the endoplasmic reticulum-Golgi intermediate compartment (By similarity). Interacts (in GDP-bound form) with lipid phosphatase MTMR7 (By similarity).|||Membrane|||Preautophagosomal structure membrane|||Prenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1).|||Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP).|||Rab-1B binds GTP and GDP and possesses intrinsic GTPase activity.|||The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Required to modulate the compacted morphology of the Golgi. Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity).|||perinuclear region http://togogenome.org/gene/9541:RAB14 ^@ http://purl.uniprot.org/uniprot/A0A2K5WS33|||http://purl.uniprot.org/uniprot/A0A8J8XWB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Recycling endosome|||phagosome|||trans-Golgi network membrane http://togogenome.org/gene/9541:HTR1A ^@ http://purl.uniprot.org/uniprot/X2C6R0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.|||Membrane|||dendrite http://togogenome.org/gene/9541:MYBL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2A1|||http://purl.uniprot.org/uniprot/A0A2K5V2D1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PRKCE ^@ http://purl.uniprot.org/uniprot/A0A2K5W8T8|||http://purl.uniprot.org/uniprot/G7PM48 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.|||Cell membrane|||Cytoplasm|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.|||Nucleus|||cytoskeleton|||perinuclear region http://togogenome.org/gene/9541:CA10 ^@ http://purl.uniprot.org/uniprot/Q9N085 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Does not have a catalytic activity. http://togogenome.org/gene/9541:ATP13A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Membrane http://togogenome.org/gene/9541:CACNB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYN9|||http://purl.uniprot.org/uniprot/A0A2K5UYR3|||http://purl.uniprot.org/uniprot/A0A2K5UYS6|||http://purl.uniprot.org/uniprot/A0A2K5UYT7|||http://purl.uniprot.org/uniprot/A0A2K5UYV0|||http://purl.uniprot.org/uniprot/A0A2K5UYX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.|||sarcolemma http://togogenome.org/gene/9541:APH1A ^@ http://purl.uniprot.org/uniprot/A0A2K5U529|||http://purl.uniprot.org/uniprot/G7NTS6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/9541:NLK ^@ http://purl.uniprot.org/uniprot/A0A7N9IE49|||http://purl.uniprot.org/uniprot/A0A8J8Y4V7|||http://purl.uniprot.org/uniprot/G7PTW3 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9541:CDKL2 ^@ http://purl.uniprot.org/uniprot/Q4R7T5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||Cytoplasm|||Nucleus|||The [NKR]KIAxRE motif seems to be a cyclin-binding region. http://togogenome.org/gene/9541:PPP1CC ^@ http://purl.uniprot.org/uniprot/A0A2K5WK94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||Cleavage furrow|||Midbody|||microtubule organizing center|||nucleolus|||nucleoplasm http://togogenome.org/gene/9541:GCK ^@ http://purl.uniprot.org/uniprot/A0A2K5VIQ1 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9541:CHD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UW80|||http://purl.uniprot.org/uniprot/A0A8J8XLE1|||http://purl.uniprot.org/uniprot/G7P802 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ST18 ^@ http://purl.uniprot.org/uniprot/A0A2K5X706 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYT1 family.|||Nucleus http://togogenome.org/gene/9541:SERPINH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VI97|||http://purl.uniprot.org/uniprot/A0A7N9CCH8 ^@ Function|||Similarity ^@ Belongs to the serpin family.|||Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. http://togogenome.org/gene/9541:GPR87 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBA8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:LOC102134311 ^@ http://purl.uniprot.org/uniprot/A0A8J8XRW3|||http://purl.uniprot.org/uniprot/G7PG07 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SUSD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGV3|||http://purl.uniprot.org/uniprot/A0A2K5VGW4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:RECQL5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VN90|||http://purl.uniprot.org/uniprot/A0A2K5VNC5 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/9541:CAMK2D ^@ http://purl.uniprot.org/uniprot/A0A2K5U5R5|||http://purl.uniprot.org/uniprot/A0A2K5U5S0|||http://purl.uniprot.org/uniprot/A0A2K5U5S1|||http://purl.uniprot.org/uniprot/A0A2K5U5S7|||http://purl.uniprot.org/uniprot/A0A2K5U5T6|||http://purl.uniprot.org/uniprot/G7P650|||http://purl.uniprot.org/uniprot/I7GBV4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9541:PLPBP ^@ http://purl.uniprot.org/uniprot/G7PD65 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. http://togogenome.org/gene/9541:FAM168B ^@ http://purl.uniprot.org/uniprot/A0A2K5WWF8|||http://purl.uniprot.org/uniprot/A0A7N9CS80 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/9541:CIBAR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CIBAR family.|||centriole|||cilium basal body http://togogenome.org/gene/9541:FAM133A ^@ http://purl.uniprot.org/uniprot/A0A2K5UK81 ^@ Similarity ^@ Belongs to the FAM133 family. http://togogenome.org/gene/9541:CA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCS1|||http://purl.uniprot.org/uniprot/A0A2K5UCT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-carbonic anhydrase family.|||Cytoplasm|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9541:WNT11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEE2|||http://purl.uniprot.org/uniprot/G7PNA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:PLK4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.|||Cleavage furrow|||centriole http://togogenome.org/gene/9541:OCIAD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ22|||http://purl.uniprot.org/uniprot/A0A2K5VJ58|||http://purl.uniprot.org/uniprot/G7P516 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OCIAD1 family.|||Endosome|||Interacts with STAT3.|||Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.|||The OCIA domain is necessary and sufficient for endosomal localization. http://togogenome.org/gene/9541:CFTR ^@ http://purl.uniprot.org/uniprot/A0A2K5U4F4|||http://purl.uniprot.org/uniprot/A0A2K5U4G6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.|||Cell membrane|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.|||Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.|||Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and SLC9A3R1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through SLC9A3R1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.|||Recycling endosome membrane http://togogenome.org/gene/9541:EPC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPI8|||http://purl.uniprot.org/uniprot/A0A2K5TPK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/9541:ADH4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCM9 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily. http://togogenome.org/gene/9541:COQ5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL38 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).|||Mitochondrion inner membrane http://togogenome.org/gene/9541:LOC102136648 ^@ http://purl.uniprot.org/uniprot/A0A2K5UB41 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:GPR34 ^@ http://purl.uniprot.org/uniprot/Q2ACI0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:TMEM254 ^@ http://purl.uniprot.org/uniprot/A0A2K5V827 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GAPDHS ^@ http://purl.uniprot.org/uniprot/G7PX96|||http://purl.uniprot.org/uniprot/Q4R3T1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer.|||May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity).|||The testis-specific N-terminal extension mediates tight association with the cytoskeletal fibrous sheath of the spermatozoa flagellum, possibly via interchain disulfide-bonding of Cys-21 with sheath components. http://togogenome.org/gene/9541:ZWILCH ^@ http://purl.uniprot.org/uniprot/A0A2K5TJD5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZWILCH family.|||Component of the RZZ complex.|||Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.|||kinetochore http://togogenome.org/gene/9541:MMD ^@ http://purl.uniprot.org/uniprot/A0A8J8XAH4|||http://purl.uniprot.org/uniprot/G7PUD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9541:HOXC9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ58|||http://purl.uniprot.org/uniprot/G7PHW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9541:CERS4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM35 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9541:IL4R ^@ http://purl.uniprot.org/uniprot/A0A2K5V580 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Membrane|||Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. http://togogenome.org/gene/9541:SLC4A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.|||Membrane http://togogenome.org/gene/9541:APOO ^@ http://purl.uniprot.org/uniprot/A0A2K5X7S8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:MRPS14 ^@ http://purl.uniprot.org/uniprot/A0A2K5VK63 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/9541:RBMX ^@ http://purl.uniprot.org/uniprot/Q4R7F0 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Arg-185 is dimethylated, probably to asymmetric dimethylarginine.|||Homomultimer. Found in the supraspliceosome complex. Identified in the spliceosome C complex. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, NCOA5 and PPP1CA. Interacts with CLK2, KHDRBS2, KHDRBS3, SAFB/SAFB1, TRA2B and YTHDC1. Interacts with ERAP1; the interaction is RNA-independent (By similarity). Interacts with PPIA/CYPA (By similarity).|||Nucleus|||O-glycosylated.|||RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment (By similarity).|||The RRM domain is necessary for RNA-binding, but not for splice site selection, indicating that its splicing activity does not require direct binding to RNA. http://togogenome.org/gene/9541:P4HA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9541:HDX ^@ http://purl.uniprot.org/uniprot/A0A2K5W8X6|||http://purl.uniprot.org/uniprot/A0A2K5W8Y0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LTK ^@ http://purl.uniprot.org/uniprot/A0A2K5VEJ1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. http://togogenome.org/gene/9541:LOC101866007 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDA9 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/9541:TAF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVS7|||http://purl.uniprot.org/uniprot/A0A2K5TVS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF1 family.|||Nucleus http://togogenome.org/gene/9541:INTS12 ^@ http://purl.uniprot.org/uniprot/G7P614|||http://purl.uniprot.org/uniprot/Q8WNV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Integrator subunit 12 family.|||Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.|||Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.|||Nucleus http://togogenome.org/gene/9541:MTX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAE1|||http://purl.uniprot.org/uniprot/A0A8J8Y6Z0|||http://purl.uniprot.org/uniprot/G7P7U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:LOC102123081 ^@ http://purl.uniprot.org/uniprot/Q4R3H4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCA family.|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.|||Tubulin-folding protein; involved in the early step of the tubulin folding pathway.|||cytoskeleton http://togogenome.org/gene/9541:NTNG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0R8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ZDHHC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6M7|||http://purl.uniprot.org/uniprot/A0A2K5U6N5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:FUT7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9541:SERPINA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSD9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:SLC35F6 ^@ http://purl.uniprot.org/uniprot/A0A7N9DCH9|||http://purl.uniprot.org/uniprot/A0A8J8Y2N0|||http://purl.uniprot.org/uniprot/G7PLU1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLC35F solute transporter family.|||Interacts with SLC25A5.|||May play a role as a nucleotide-sugar transporter.|||Membrane|||Mitochondrion http://togogenome.org/gene/9541:HDAC9 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. http://togogenome.org/gene/9541:MAPKAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3K2|||http://purl.uniprot.org/uniprot/A0A2K5V3L0|||http://purl.uniprot.org/uniprot/A0A2K5V3Q6|||http://purl.uniprot.org/uniprot/G8F3Q9 ^@ Similarity ^@ Belongs to the SIN1 family. http://togogenome.org/gene/9541:LHX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVG1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:HMCN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLR4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LCE3A ^@ http://purl.uniprot.org/uniprot/G8F3F0 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9541:LOC102145051 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYW3 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:ASPDH ^@ http://purl.uniprot.org/uniprot/A0A2K5WZM4|||http://purl.uniprot.org/uniprot/A0A7N9C8S5 ^@ Similarity ^@ Belongs to the L-aspartate dehydrogenase family. http://togogenome.org/gene/9541:HMOX1 ^@ http://purl.uniprot.org/uniprot/I7GJG7 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/9541:ERCC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVW5|||http://purl.uniprot.org/uniprot/A0A2K5TVW7|||http://purl.uniprot.org/uniprot/A0A7N9IFE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERCC1/RAD10/SWI10 family.|||Nucleus http://togogenome.org/gene/9541:BANF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPY1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NSF ^@ http://purl.uniprot.org/uniprot/A0A2K5V7I5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. http://togogenome.org/gene/9541:LAMTOR5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR5 family.|||Lysosome http://togogenome.org/gene/9541:MADD ^@ http://purl.uniprot.org/uniprot/A0A2K5UAJ4|||http://purl.uniprot.org/uniprot/A0A2K5UB21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MADD family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:MOV10 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYR1|||http://purl.uniprot.org/uniprot/A0A2K5TYR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.|||P-body http://togogenome.org/gene/9541:AMPD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9H5|||http://purl.uniprot.org/uniprot/A0A2K5W9K5 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Homotetramer. http://togogenome.org/gene/9541:RXRA ^@ http://purl.uniprot.org/uniprot/Q2PFT8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Homodimer. Heterodimer; with a rar molecule.|||Nucleus|||Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. http://togogenome.org/gene/9541:SLC28A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/9541:CDH6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TW62 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:NFE2L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9I0|||http://purl.uniprot.org/uniprot/A0A2K5V9I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. CNC subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9541:PIAS4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WS64 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/9541:IL1RN ^@ http://purl.uniprot.org/uniprot/A0A7N9DF26|||http://purl.uniprot.org/uniprot/Q866R8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.|||Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9541:TAF5L ^@ http://purl.uniprot.org/uniprot/A0A2K5U671 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/9541:TEC ^@ http://purl.uniprot.org/uniprot/A0A2K5TW50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9541:CAV1 ^@ http://purl.uniprot.org/uniprot/I7GJT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||Membrane raft|||caveola http://togogenome.org/gene/9541:NXPE3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZK5|||http://purl.uniprot.org/uniprot/G7NZQ2 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/9541:TJP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTJ4|||http://purl.uniprot.org/uniprot/A0A2K5TTL3|||http://purl.uniprot.org/uniprot/A0A2K5TTQ6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9541:RUNDC3B ^@ http://purl.uniprot.org/uniprot/Q4R7B9 ^@ Similarity|||Subunit ^@ Belongs to the RUNDC3 family.|||Interacts with RAP2A. http://togogenome.org/gene/9541:MED30 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZT7|||http://purl.uniprot.org/uniprot/G7PCQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9541:ARPC3 ^@ http://purl.uniprot.org/uniprot/I7GIB8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC3 family.|||Component of the Arp2/3 complex.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/9541:LOC102117030 ^@ http://purl.uniprot.org/uniprot/A0A8J8YEL1|||http://purl.uniprot.org/uniprot/G7PQW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:FGD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VV41 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:EPS8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTB7 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/9541:IL36B ^@ http://purl.uniprot.org/uniprot/A0A2K5UUV5|||http://purl.uniprot.org/uniprot/A0A2K5UV63|||http://purl.uniprot.org/uniprot/Q4R3X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9541:FAM118B ^@ http://purl.uniprot.org/uniprot/A0A2K5W7F6|||http://purl.uniprot.org/uniprot/A0A7N9CHQ2|||http://purl.uniprot.org/uniprot/A0A805R453|||http://purl.uniprot.org/uniprot/Q4R836 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM118 family.|||Cajal body|||May play a role in Cajal bodies formation. http://togogenome.org/gene/9541:PSMB9 ^@ http://purl.uniprot.org/uniprot/A5HLX2|||http://purl.uniprot.org/uniprot/G8F5I6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:PPP1R1C ^@ http://purl.uniprot.org/uniprot/A0A2K5WIU3 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/9541:PON2 ^@ http://purl.uniprot.org/uniprot/I7GH36 ^@ Cofactor|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit. http://togogenome.org/gene/9541:EMC8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFV4|||http://purl.uniprot.org/uniprot/A0A8J8YKW4|||http://purl.uniprot.org/uniprot/G7PZW7 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/9541:STXBP5L ^@ http://purl.uniprot.org/uniprot/A0A2K5U0F5|||http://purl.uniprot.org/uniprot/A0A2K5U0G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:TCP11L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WU60|||http://purl.uniprot.org/uniprot/G7PQG3|||http://purl.uniprot.org/uniprot/I7GM92 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9541:GSTK1 ^@ http://purl.uniprot.org/uniprot/A0A023JCQ9 ^@ Similarity ^@ Belongs to the GST superfamily. Kappa family. http://togogenome.org/gene/9541:CHRNA6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:MOCOS ^@ http://purl.uniprot.org/uniprot/A0A2K5UYE8 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.|||Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. http://togogenome.org/gene/9541:INKA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR15|||http://purl.uniprot.org/uniprot/A0A7N9D0M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INKA family.|||Nucleus http://togogenome.org/gene/9541:LOC102124421 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7N0|||http://purl.uniprot.org/uniprot/A0A2K5X7N6 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. TRA1 subfamily. http://togogenome.org/gene/9541:BRCC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU36 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M67A family. BRCC36 subfamily.|||Binds 1 zinc ion per subunit.|||Component of the BRCA1-A complex. Component of the BRISC complex. Both the BRCA1-A complex and the BRISC complex bind polyubiquitin.|||Cytoplasm|||Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.|||Nucleus|||spindle pole http://togogenome.org/gene/9541:ARHGEF6 ^@ http://purl.uniprot.org/uniprot/A0A7N9D7C5|||http://purl.uniprot.org/uniprot/A0A8J8XE62|||http://purl.uniprot.org/uniprot/G7Q1T5 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/9541:FAM136A ^@ http://purl.uniprot.org/uniprot/I7G9C4 ^@ Similarity ^@ Belongs to the FAM136 family. http://togogenome.org/gene/9541:SERPING1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSV9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:POT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TT99|||http://purl.uniprot.org/uniprot/A0A2K5TTA6|||http://purl.uniprot.org/uniprot/Q95K48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the telombin family.|||Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity (By similarity).|||Homodimer or homooligomer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP, ACD and POT1. Binds single-stranded telomeric DNA as a monomer. Associated component of the telomerase holoenzyme complex. Found in a complex with TERF1, TINF2 and TNKS1. Interacts with TNKS1. Forms heterodimers with ACD. Identified in a complex with ACD and single-stranded telomeric DNA.|||Nucleus|||telomere http://togogenome.org/gene/9541:KIF24 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWK2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:LOC102143175 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/9541:CALR ^@ http://purl.uniprot.org/uniprot/Q4R6K8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with PDIA3 through the tip of the extended arm formed by the P-domain.|||Belongs to the calreticulin family.|||Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity).|||Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity (By similarity).|||Cell surface|||Cortical granule|||Cytolytic granule|||Endoplasmic reticulum lumen|||Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57 and SPACA9 (By similarity). Interacts with TRIM21. Interacts with NR3C1. Interacts with PPIB. Interacts (via P-domain) with PDIA5. Interacts with CLCC1 (By similarity).|||Sarcoplasmic reticulum lumen|||The interaction with glycans occurs through a binding site in the globular lectin domain.|||The zinc binding sites are localized to the N-domain.|||cytosol|||extracellular matrix http://togogenome.org/gene/9541:PTPN11 ^@ http://purl.uniprot.org/uniprot/A0A2K5WT01 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. http://togogenome.org/gene/9541:PREB ^@ http://purl.uniprot.org/uniprot/A0A2K5X0C4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat SEC12 family.|||Endoplasmic reticulum membrane|||Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.|||Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. http://togogenome.org/gene/9541:CACYBP ^@ http://purl.uniprot.org/uniprot/Q4R4P3 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1 (By similarity). Interacts with protein of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner (By similarity).|||Cytoplasm|||May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity).|||Nucleus|||Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations (By similarity). http://togogenome.org/gene/9541:NPY5R ^@ http://purl.uniprot.org/uniprot/G8F2E3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane|||Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. http://togogenome.org/gene/9541:TOR3A ^@ http://purl.uniprot.org/uniprot/A0A2K5WW44|||http://purl.uniprot.org/uniprot/A0A7N9D9M0 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. Torsin subfamily. http://togogenome.org/gene/9541:GIMAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VW30 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9541:MTERF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYN0 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9541:ST3GAL2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZS4|||http://purl.uniprot.org/uniprot/G7Q1L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:CBX7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WF83 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TRAF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRW6|||http://purl.uniprot.org/uniprot/A0A2K5VRZ9|||http://purl.uniprot.org/uniprot/A0A7N9C7B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9541:SARM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UA73 ^@ Similarity ^@ Belongs to the SARM1 family. http://togogenome.org/gene/9541:SH3RF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3RF family.|||lamellipodium|||perinuclear region|||trans-Golgi network http://togogenome.org/gene/9541:DLX4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFH5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NGF ^@ http://purl.uniprot.org/uniprot/G7NX40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted http://togogenome.org/gene/9541:KXD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQP7|||http://purl.uniprot.org/uniprot/G7PWZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KXD1 family.|||Lysosome membrane http://togogenome.org/gene/9541:ACKR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMM7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:SLC4A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8G8|||http://purl.uniprot.org/uniprot/A0A2K5U8K0|||http://purl.uniprot.org/uniprot/A0A2K5U8K4|||http://purl.uniprot.org/uniprot/A0A2K5U8L5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PIWIL4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1P0 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/9541:LSM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3J7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Cytoplasm|||Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.|||P-body|||Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. http://togogenome.org/gene/9541:PEMT ^@ http://purl.uniprot.org/uniprot/A0A2K5WQG5|||http://purl.uniprot.org/uniprot/G7PTS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.|||Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9541:PLA2G15 ^@ http://purl.uniprot.org/uniprot/A0A2K5X057 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9541:SLC32A1 ^@ http://purl.uniprot.org/uniprot/Q95KE2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient (By similarity). May also transport beta-alanine (By similarity). Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake (By similarity).|||Belongs to the amino acid/polyamine transporter 2 family.|||Cytoplasmic vesicle membrane|||Juge et al. shows that SLC32A1 is a symporter of both 4-aminobutanoate or glycine or beta-alanine with Cl(-) that operates according an electrical gradient without the need for a chemical gradient (By similarity). However Farsi et al. and Egashira et al. confirm that SLC32A1 is an antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or glycine and exclude any coupling with chloride (By similarity).|||Presynapse http://togogenome.org/gene/9541:RPL36 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFN5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/9541:ANAPC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X245 ^@ Similarity ^@ Belongs to the APC1 family. http://togogenome.org/gene/9541:RFNG ^@ http://purl.uniprot.org/uniprot/A0A2K5WMJ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:INA ^@ http://purl.uniprot.org/uniprot/A0A2K5TNS1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:NDUFS4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XSU5|||http://purl.uniprot.org/uniprot/G7P7H7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS4 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ASPHD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFE4 ^@ Similarity ^@ Belongs to the aspartyl/asparaginyl beta-hydroxylase family. http://togogenome.org/gene/9541:C18H18orf21 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZR5|||http://purl.uniprot.org/uniprot/A0A2K5X0B3 ^@ Similarity ^@ Belongs to the UPF0711 family. http://togogenome.org/gene/9541:ADAM2 ^@ http://purl.uniprot.org/uniprot/Q28478 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ A tripeptide motif (FDE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.|||Expressed specifically in testis.|||Heterodimer with ADAM1/fertilin subunit alpha.|||Membrane|||Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity).|||The signal and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa. http://togogenome.org/gene/9541:MAP2K1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TK68 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:SMNDC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMN family.|||Cajal body http://togogenome.org/gene/9541:RPL18A ^@ http://purl.uniprot.org/uniprot/A0A2K5VJD7|||http://purl.uniprot.org/uniprot/I7GNJ4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL20 family. http://togogenome.org/gene/9541:NDUFS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSC1|||http://purl.uniprot.org/uniprot/A0A7N9CR31 ^@ Similarity ^@ Belongs to the complex I 49 kDa subunit family. http://togogenome.org/gene/9541:VAT1 ^@ http://purl.uniprot.org/uniprot/I7GJY5 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9541:TKTL1 ^@ http://purl.uniprot.org/uniprot/Q4R6M8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transketolase family.|||Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.|||Cytoplasm|||Homodimer.|||Nucleus http://togogenome.org/gene/9541:VEPH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFK4 ^@ Similarity ^@ Belongs to the MELT/VEPH family. http://togogenome.org/gene/9541:TRAPPC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEM8|||http://purl.uniprot.org/uniprot/G7NTI2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/9541:ENSA ^@ http://purl.uniprot.org/uniprot/A0A2K5TU80 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/9541:IPO9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBP1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:SMC3 ^@ http://purl.uniprot.org/uniprot/G7PDY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC3 subfamily.|||Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.|||Nucleus|||centromere http://togogenome.org/gene/9541:GBA2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAR2|||http://purl.uniprot.org/uniprot/G7PRZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the non-lysosomal glucosylceramidase family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. http://togogenome.org/gene/9541:BGN ^@ http://purl.uniprot.org/uniprot/A0A8J8YQ10|||http://purl.uniprot.org/uniprot/G7Q1Z4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||May be involved in collagen fiber assembly.|||extracellular matrix http://togogenome.org/gene/9541:NAA35 ^@ http://purl.uniprot.org/uniprot/G7PSM3|||http://purl.uniprot.org/uniprot/Q4R708 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.|||Belongs to the MAK10 family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.|||Cytoplasm http://togogenome.org/gene/9541:TRMT5 ^@ http://purl.uniprot.org/uniprot/Q95KJ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.|||Mitochondrion matrix|||Monomer.|||Nucleus http://togogenome.org/gene/9541:CXCL9 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYG4|||http://purl.uniprot.org/uniprot/G7P558 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9541:EML5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCJ7|||http://purl.uniprot.org/uniprot/A0A2K5UCJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat EMAP family.|||May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.|||cytoskeleton http://togogenome.org/gene/9541:ARHGEF11 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL91|||http://purl.uniprot.org/uniprot/A0A2K5WLE1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Membrane http://togogenome.org/gene/9541:RAN ^@ http://purl.uniprot.org/uniprot/Q4R4M9 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation by KAT5 at Lys-134 is increased during mitosis, impairs RANGRF binding and enhances RCC1 binding. Acetylation at Lys-37 enhances the association with nuclear export components. Deacetylation of Lys-37 by SIRT7 regulates the nuclear export of NF-kappa-B subunit RELA/p65.|||Belongs to the small GTPase superfamily. Ran family.|||Cytoplasm|||GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation.|||Melanosome|||Mg(2+) interacts primarily with the phosphate groups of the bound guanine nucleotide.|||Monomer. Interacts with RANGAP1, which promotes RAN-mediated GTP hydrolysis. Interacts with KPNB1. Interaction with KPNB1 inhibits RANGAP1-mediated stimulation of GTPase activity. Interacts with RCC1 which promotes the exchange of RAN-bound GDP by GTP. Interaction with KPNB1 inhibits RCC1-mediated exchange of RAN-bound GDP by GTP. Interacts (GTP-bound form) with TNPO1; the interaction is direct. Interacts (GTP-bound form) with TNPO3; the interaction is direct. Interacts with KPNB1 and with TNPO1; both inhibit RAN GTPase activity. Interacts (via C-terminus) with RANBP1, which alleviates the inhibition of RAN GTPase activity. Interacts with RANGRF, which promotes the release of bound guanine nucleotide. RANGRF and RCC1 compete for an overlapping binding site on RAN. Identified in a complex with KPNA2 and CSE1L; interaction with RANBP1 mediates dissociation of RAN from this complex. Interaction with both RANBP1 and KPNA2 promotes dissociation of the complex between RAN and KPNB1. Identified in a complex composed of RAN, RANGAP1 and RANBP1. Identified in a complex that contains TNPO1, RAN and RANBP1. Identified in a nuclear export complex with XPO1. Found in a nuclear export complex with RANBP3 and XPO1. Interacts with RANBP2/NUP358. Interaction with RANBP1 or RANBP2 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1 (By similarity). Found in a nuclear export complex with RAN, XPO5 and pre-miRNA (By similarity). Interacts (GTP-bound form) with XPO5 (By similarity). Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Interacts with RANBP9 and RANBP10. Interacts in its GTP-bound form with BIRC5/survivin at S and M phases of the cell cycle. Interacts with TERT; the interaction requires hydrogen peroxide-mediated phosphorylation of TERT and transports TERT to the nucleus. Interacts with MAD2L2. Interacts with VRK1 and VRK3. Interacts with VRK2 (By similarity). Interacts with NEMP1 and KPNB1 (By similarity). Interacts (GDP-bound form) with NUTF2; regulates RAN nuclear import. Interacts with CAPG; mediates CAPG nuclear import. Interacts with NUP153. Interacts with the AR N-terminal poly-Gln region; the interaction with AR is inversely correlated with the poly-Gln length (By similarity). Interacts with MYCBP2, which promotes RAN-mediated GTP hydrolysis (By similarity). Interacts with EPG5 (By similarity).|||Nucleus|||Nucleus envelope|||cytosol http://togogenome.org/gene/9541:BCAT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVV1 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9541:LOC101866651 ^@ http://purl.uniprot.org/uniprot/A0A2K5WI17|||http://purl.uniprot.org/uniprot/A0A2K5WI46 ^@ Similarity ^@ Belongs to the CBP3 family. http://togogenome.org/gene/9541:NOXRED1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRK6 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/9541:EXOC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMY4 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/9541:VSIG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULF2|||http://purl.uniprot.org/uniprot/A0A8J8YS04|||http://purl.uniprot.org/uniprot/G7Q3F3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CCN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3T5|||http://purl.uniprot.org/uniprot/G7NTL1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:OAZ1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UD54|||http://purl.uniprot.org/uniprot/A0A7N9CEE9|||http://purl.uniprot.org/uniprot/Q25Q15 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/9541:USP48 ^@ http://purl.uniprot.org/uniprot/A0A2K5X372|||http://purl.uniprot.org/uniprot/A0A2K5X3E9|||http://purl.uniprot.org/uniprot/A0A2K5X3Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Nucleus http://togogenome.org/gene/9541:TMEM184C ^@ http://purl.uniprot.org/uniprot/A0A2K5U2Y7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NDUFB8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TS24 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB8 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:CHAF1A ^@ http://purl.uniprot.org/uniprot/A0A2K5VAM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CHAF1A family.|||Nucleus http://togogenome.org/gene/9541:PAQR7 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y7E0|||http://purl.uniprot.org/uniprot/G7NVX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9541:SPAG9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDN6|||http://purl.uniprot.org/uniprot/A0A2K5VDR6 ^@ Similarity ^@ Belongs to the JIP scaffold family. http://togogenome.org/gene/9541:GNAI3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIQ6|||http://purl.uniprot.org/uniprot/G7NW34 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9541:LOC102124750 ^@ http://purl.uniprot.org/uniprot/A0A2K5UH57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102138187 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQN6|||http://purl.uniprot.org/uniprot/A0A2K5TQP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/9541:TMEM258 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST5 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9541:LAMTOR2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YRM5|||http://purl.uniprot.org/uniprot/G7NV75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAMAD family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9541:LOC102133005 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1Z1 ^@ Function|||Similarity ^@ Belongs to the TYW1 family.|||Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis. http://togogenome.org/gene/9541:EBF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U465|||http://purl.uniprot.org/uniprot/A0A2K5U4D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/9541:ZHX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WN38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/9541:TMEM50A ^@ http://purl.uniprot.org/uniprot/A0A2K5TLA9|||http://purl.uniprot.org/uniprot/G7NVW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/9541:TRPM6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTN9|||http://purl.uniprot.org/uniprot/A0A2K5WU55 ^@ Similarity|||Subcellular Location Annotation ^@ In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.|||Membrane http://togogenome.org/gene/9541:FGF7 ^@ http://purl.uniprot.org/uniprot/A0A7N9CQ66 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:DCP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXJ7|||http://purl.uniprot.org/uniprot/A0A2K5WXS4 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DCP2 subfamily. http://togogenome.org/gene/9541:TRIQK ^@ http://purl.uniprot.org/uniprot/A0A2K5UNC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIQK family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:SLC12A3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XK92|||http://purl.uniprot.org/uniprot/G7Q167 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9541:SFR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7T0|||http://purl.uniprot.org/uniprot/A0A2K5V7U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SFR1/MEI5 family.|||Nucleus http://togogenome.org/gene/9541:PGAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI inositol-deacylase family.|||Endoplasmic reticulum membrane|||Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.|||Membrane http://togogenome.org/gene/9541:PMP2 ^@ http://purl.uniprot.org/uniprot/A0A7N9IHI1|||http://purl.uniprot.org/uniprot/G7PC38 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm|||May play a role in lipid transport protein in Schwann cells. May bind cholesterol.|||Monomer. http://togogenome.org/gene/9541:CDH20 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFT1|||http://purl.uniprot.org/uniprot/A0A7N9IGY0|||http://purl.uniprot.org/uniprot/G7PWW3 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:NFIA ^@ http://purl.uniprot.org/uniprot/A0A2K5U2W6|||http://purl.uniprot.org/uniprot/A0A2K5U2Y1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/9541:RPAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UY91|||http://purl.uniprot.org/uniprot/A0A7N9CNX1|||http://purl.uniprot.org/uniprot/G8F395 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.|||Belongs to the RPAP2 family.|||Nucleus|||Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. http://togogenome.org/gene/9541:DLGAP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBW4|||http://purl.uniprot.org/uniprot/A0A2K5VC01 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9541:CPB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX20 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9541:JAG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V753|||http://purl.uniprot.org/uniprot/A0A2K5V7A4 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/9541:FGF13 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQV6|||http://purl.uniprot.org/uniprot/A0A2K5UQV7|||http://purl.uniprot.org/uniprot/I7GLK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Cytoplasm|||dendrite|||filopodium|||growth cone|||sarcolemma http://togogenome.org/gene/9541:PIK3R3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJZ8|||http://purl.uniprot.org/uniprot/A0A7N9DEU9 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/9541:BARX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJU7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:DBR1 ^@ http://purl.uniprot.org/uniprot/I7GEG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lariat debranching enzyme family.|||Nucleus http://togogenome.org/gene/9541:CLIC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1A1|||http://purl.uniprot.org/uniprot/A0A7N9CK20 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cell membrane|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane|||Nucleus membrane http://togogenome.org/gene/9541:LETM2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XD20|||http://purl.uniprot.org/uniprot/G7PD74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TXLNA ^@ http://purl.uniprot.org/uniprot/A0A2K5U644|||http://purl.uniprot.org/uniprot/G8F3T7 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9541:KIF5A ^@ http://purl.uniprot.org/uniprot/A0A2K5WRA2|||http://purl.uniprot.org/uniprot/A0A8J8YRW8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:GCH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6Y7 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I family. http://togogenome.org/gene/9541:MT3 ^@ http://purl.uniprot.org/uniprot/G7Q160|||http://purl.uniprot.org/uniprot/Q2PFZ0 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium (By similarity).|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9541:UCP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VI31 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||May undergo ubiquitin-mediated proteasomal degradation.|||Membrane|||Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:TPM4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0H0|||http://purl.uniprot.org/uniprot/A0A2K5W0K9|||http://purl.uniprot.org/uniprot/G7PZP8|||http://purl.uniprot.org/uniprot/I7G4Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9541:LOC102132836 ^@ http://purl.uniprot.org/uniprot/A0A7N9CSE3 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9541:NXPH1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XG87|||http://purl.uniprot.org/uniprot/G7P1A3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9541:GPATCH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WG60 ^@ Similarity ^@ Belongs to the GPATCH1 family. http://togogenome.org/gene/9541:GATC ^@ http://purl.uniprot.org/uniprot/A0A8J8XNI1|||http://purl.uniprot.org/uniprot/G7PJ44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9541:F2R ^@ http://purl.uniprot.org/uniprot/A0A2K5VPA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102128333 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBN8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:DLK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMQ6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:CPA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDK4 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9541:TXNL4A ^@ http://purl.uniprot.org/uniprot/A0A2K5U5Y9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/9541:CDK18 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7A1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:VCAN ^@ http://purl.uniprot.org/uniprot/A0A2K5V3Q2|||http://purl.uniprot.org/uniprot/A0A2K5V3R5|||http://purl.uniprot.org/uniprot/A0A2K5V3U3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aggrecan/versican proteoglycan family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:TRAM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0Z4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/9541:CDK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPV1|||http://purl.uniprot.org/uniprot/A0A2K5VPW1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:ARMT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VA55 ^@ Domain|||Function|||Similarity ^@ Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.|||Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.|||Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine. http://togogenome.org/gene/9541:ITGA8 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9541:TERF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X903|||http://purl.uniprot.org/uniprot/A0A2K5X908|||http://purl.uniprot.org/uniprot/G7PC12 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.|||Homodimer.|||Nucleus|||telomere http://togogenome.org/gene/9541:LOC102125892 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1X0 ^@ Similarity ^@ Belongs to the COX20 family. http://togogenome.org/gene/9541:PMS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W455|||http://purl.uniprot.org/uniprot/A0A2K5W467 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/9541:BCL2L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPG2|||http://purl.uniprot.org/uniprot/A0A7N9D351 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane|||Mitochondrion matrix|||Nucleus membrane|||centrosome|||cytosol|||synaptic vesicle membrane http://togogenome.org/gene/9541:TTLL9 ^@ http://purl.uniprot.org/uniprot/A0A7N9C9K3 ^@ Similarity ^@ Belongs to the tubulin--tyrosine ligase family. http://togogenome.org/gene/9541:SUPT5H ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT5 family.|||Nucleus http://togogenome.org/gene/9541:KARS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZ51|||http://purl.uniprot.org/uniprot/A0A2K5WZR2 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:LSM3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W897 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/9541:NUP155 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the non-repetitive/WGA-negative nucleoporin family.|||nuclear pore complex http://togogenome.org/gene/9541:PCCA ^@ http://purl.uniprot.org/uniprot/A0A2K5UJN7 ^@ Subcellular Location Annotation ^@ Mitochondrion matrix http://togogenome.org/gene/9541:DPP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXJ1 ^@ Subcellular Location Annotation ^@ Cell membrane|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/9541:BRF2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y646|||http://purl.uniprot.org/uniprot/G7PD66|||http://purl.uniprot.org/uniprot/Q4R318 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIB family.|||Component of TFIIIB complexes. The TFIIIB complex has two activities, alpha and beta. The TFIIIB-alpha activity complex is composed of TBP, BDP1, and a complex containing both BRF2 and at least four stably associated proteins; this complex inhibits the transcription by pol III via its phosphorylation by CK2; YY1 facilitates the TFIIIB-alpha complex formation. Interacts with TBP; this interaction promotes recruitment of BRF2 to TATA box-containing promoters. Interacts with TBP and the BURE sequence (GC-rich sequence downstream from the TATA box) to form a strong ternary complex which is joined by BDP1; this ternary complex stimulates pol III transcription. Forms a trimeric complex composed of TBP, BRF2 and mini-SNAPc complex (SNAP43, SNAP50, and the N-terminal third of SNAP190) on the promoter. Assembly of the TBP-BRF2 complex is stimulated by SNAP190. Interacts with MAF1 and SNAPC4.|||General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress.|||In response to oxidative stress, a Cys-residue is reversibly oxidized to cysteine sulfenic acid. This impairs formation of a ternary complex with TBP and DNA and down-regulates expression of target genes in response to oxidative stress.|||Nucleus http://togogenome.org/gene/9541:LOC102119787 ^@ http://purl.uniprot.org/uniprot/G7PCH4|||http://purl.uniprot.org/uniprot/Q4R5B6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDH/MDH superfamily. LDH family.|||Cytoplasm|||Homotetramer. Interacts with PTEN upstream reading frame protein MP31; the interaction leads to inhibition of mitochondrial lactate dehydrogenase activity, preventing conversion of lactate to pyruvate in mitochondria.|||Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).|||Mitochondrion inner membrane http://togogenome.org/gene/9541:OTULIN ^@ http://purl.uniprot.org/uniprot/A0A2K5WJB8|||http://purl.uniprot.org/uniprot/G7P791 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/9541:HSP90AA1 ^@ http://purl.uniprot.org/uniprot/Q4R4P1 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 90 family.|||Cell membrane|||Cytoplasm|||Homodimer. Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1, HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C or STIP1. Forms a complex containing HSP90AA1, TSC1 and TSC2; TSC1 is required to recruit TCS2 to the complex. The closed form interacts (via the middle domain and TPR repeat-binding motif) with co-chaperone TSC1 (via C-terminus). Interacts with TOM34. Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex. Interacts with CHORDC1 and DNAJC7. Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems. Interacts (via TPR repeat-binding motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity. Following LPS binding, may form a complex with CXCR4, GDF5 and HSPA8. Interacts with KSR1. Interacts with co-chaperone CDC37 (via C-terminus); the interaction inhibits HSP90AA1 ATPase activity. May interact with NWD1. Interacts with FNIP1 and FNIP2; the interaction inhibits HSP90AA1 ATPase activity. Interacts with co-chaperone AHSA1 (phosphorylated on 'Tyr-223'); the interaction activates HSP90AA1 ATPase activity and results in the dissociation of TSC1 from HSP90AA1. Interacts with FLCN in the presence of FNIP1. Interacts with HSP70, STIP1 and PTGES3. Interacts with SMYD3; this interaction enhances SMYD3 histone-lysine N-methyltransferase. Interacts with SGTA (via TPR repeats). Interacts with TTC1 (via TPR repeats). Interacts with HSF1 in an ATP-dependent manner. Interacts with MET; the interaction suppresses MET kinase activity. Interacts with ERBB2 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity. Interacts with HIF1A, KEAP1 and RHOBTB2. Interacts with HSF1; this interaction is decreased in a IER5-dependent manner, promoting HSF1 accumulation in the nucleus, homotrimerization and DNA-binding activities. Interacts with STUB1 and SMAD3. Interacts with HSP90AB1; interaction is constitutive (By similarity). Interacts with HECTD1 (via N-terminus) (By similarity). Interacts with NR3C1 (via domain NR LBD) and NR1D1 (via domain NR LBD) (By similarity). Interacts with NLPR12 (By similarity). Interacts with PDCL3 (By similarity). Interacts with TOMM70; the interaction is required for preprotein mitochondrial import. Interacts with TOMM70, IRF3 and TBK1; the interactions are direct and mediate the association of TOMM70 with IRF3 and TBK1 (By similarity). Forms a complex with ASL, ASS1 and NOS2; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway.|||ISGylated.|||In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state. Co-chaperone TSC1 promotes ATP binding and inhibits HSP90AA1 ATPase activity. Binding to phosphorylated AHSA1 promotes HSP90AA1 ATPase activity. Inhibited by geldanamycin, Ganetespib (STA-9090) and SNX-2112.|||Melanosome|||Mitochondrion|||Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response.|||Nucleus|||S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1.|||The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1.|||Ubiquitinated via 'Lys-63'-linked polyubiquitination by HECTD1. Ubiquitination promotes translocation into the cytoplasm away from the membrane and secretory pathways. http://togogenome.org/gene/9541:POGLUT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVB9 ^@ Similarity ^@ Belongs to the KDELC family. http://togogenome.org/gene/9541:CBX1 ^@ http://purl.uniprot.org/uniprot/I7GH62 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SNX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKG2|||http://purl.uniprot.org/uniprot/A0A7N9IGR1|||http://purl.uniprot.org/uniprot/Q4R503 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sorting nexin family.|||Binds phosphatidylinositol 3-phosphate (PtdIns-(3)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2) in liposome-based assays. Can bind PtdIns(3,4,5)P3 in protein:lipid overlay assays, but not in liposome-based assays (By similarity).|||Early endosome membrane|||Endosome membrane|||Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1). Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN. Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (By similarity).|||Membrane|||Predominantly forms heterodimers with BAR domain-containing sorting nexins SNX5, SNX6 and SNX32; can self-associate to form homodimers. The heterodimers are proposed to self-assemble into helical arrays on the membrane to stabilize and expand local membrane curvature underlying endosomal tubule formation. Thought to be a component of the originally described retromer complex (also called SNX-BAR retromer) which is a pentamer containing the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS) and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. Interacts with SNX5, SNX6, SNX32, VPS26A, VPS29, VPS35, DRD5, DENND5A, KALRN, RHOG (GDP-bound form). The interaction with SNX2 is reported controversially. Interacts with DNAJC13; prevented by presence of HGS. Interacts with HGS (By similarity).|||The BAR domain is able to sense membrane curvature upon dimerization. Membrane remodeling seems to implicate insertion of a N-terminal amphipathic helix (AH) in the membrane (By similarity).|||lamellipodium|||trans-Golgi network membrane http://togogenome.org/gene/9541:LOC102118592 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWH6 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/9541:TGM6 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULL3|||http://purl.uniprot.org/uniprot/A0A2K5ULL7 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9541:TMEM150C ^@ http://purl.uniprot.org/uniprot/A0A2K5ULK2|||http://purl.uniprot.org/uniprot/A0A2K5ULQ0|||http://purl.uniprot.org/uniprot/A0A7N9CHJ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102116497 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXJ3 ^@ Similarity ^@ Belongs to the cytochrome c oxidase subunit 6A family. http://togogenome.org/gene/9541:GNPAT ^@ http://purl.uniprot.org/uniprot/A0A2K5V912 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Peroxisome membrane http://togogenome.org/gene/9541:LOC102122620 ^@ http://purl.uniprot.org/uniprot/G8F5H6 ^@ Function|||Subunit ^@ In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9541:STK17B ^@ http://purl.uniprot.org/uniprot/A0A2K5UTS2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:FBLN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WC87|||http://purl.uniprot.org/uniprot/A0A2K5WCE9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fibulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:AKR1D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VT14|||http://purl.uniprot.org/uniprot/G8F421 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family.|||Monomer. http://togogenome.org/gene/9541:IFITM5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMX3 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:ACSL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WU34|||http://purl.uniprot.org/uniprot/A0A2K5WU45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:EDN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9541:MTARC2 ^@ http://purl.uniprot.org/uniprot/Q9GKW0 ^@ Cofactor|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction.|||Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MTARC2.|||Mitochondrion outer membrane|||Peroxisome|||Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. http://togogenome.org/gene/9541:HMGA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEY0|||http://purl.uniprot.org/uniprot/A0A2K5VF57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGA family.|||Nucleus http://togogenome.org/gene/9541:MOB1B ^@ http://purl.uniprot.org/uniprot/A0A2K5WX83|||http://purl.uniprot.org/uniprot/A0A2K5WXH6|||http://purl.uniprot.org/uniprot/G7P5M6 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9541:RAB39B ^@ http://purl.uniprot.org/uniprot/A0A8J8XD78|||http://purl.uniprot.org/uniprot/G7Q238 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PDHA1 ^@ http://purl.uniprot.org/uniprot/Q8HXW9 ^@ Activity Regulation|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Acetylation alters the phosphorylation pattern. Deacetylated by SIRT3 (By similarity).|||Heterotetramer of two PDHA1 and two PDHB subunits. The heterotetramer interacts with DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules (By similarity).|||Mitochondrion matrix|||Phosphorylation at Ser-232, Ser-293 and Ser-300 by PDK family kinases inactivates the enzyme; for this phosphorylation at a single site is sufficient. Phosphorylation at Ser-293 interferes with access to active site, and thereby inactivates the enzyme. Dephosphorylation at all three sites, i.e. at Ser-232, Ser-293 and Ser-300, is required for reactivation (By similarity).|||Pyruvate dehydrogenase activity is inhibited by phosphorylation of PDHA1; it is reactivated by dephosphorylation.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. http://togogenome.org/gene/9541:NCAM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSA3|||http://purl.uniprot.org/uniprot/A0A2K5VT36 ^@ Function ^@ This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. http://togogenome.org/gene/9541:FBL ^@ http://purl.uniprot.org/uniprot/I7GIX2 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Fibrillarin family. http://togogenome.org/gene/9541:SLC22A7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPK7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:RPS5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WE29|||http://purl.uniprot.org/uniprot/A0A8J8XCP0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/9541:GTF2H5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJD9|||http://purl.uniprot.org/uniprot/G7P4W3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/9541:LOC102118042 ^@ http://purl.uniprot.org/uniprot/A0A8J8YC99|||http://purl.uniprot.org/uniprot/G7NZQ6 ^@ Similarity ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. http://togogenome.org/gene/9541:VPS26C ^@ http://purl.uniprot.org/uniprot/A0A2K5VWC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS26 family.|||Endosome http://togogenome.org/gene/9541:RPS27 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4U7 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9541:PDE6D ^@ http://purl.uniprot.org/uniprot/A0A2K5W427|||http://purl.uniprot.org/uniprot/G7PKA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PDE6D/unc-119 family.|||Cytoplasmic vesicle membrane|||Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.|||Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.|||cilium basal body|||cytosol http://togogenome.org/gene/9541:GPLD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPLD1 family.|||Secreted http://togogenome.org/gene/9541:GALNT18 ^@ http://purl.uniprot.org/uniprot/A0A2K5WV86|||http://purl.uniprot.org/uniprot/G7PQQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:SDE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUP7|||http://purl.uniprot.org/uniprot/G7NTV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SDE2 family.|||Nucleus http://togogenome.org/gene/9541:RAB27B ^@ http://purl.uniprot.org/uniprot/A0A8J8YNG2|||http://purl.uniprot.org/uniprot/G7PWU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9541:IFIT1 ^@ http://purl.uniprot.org/uniprot/Q4R5F5 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IFIT family.|||Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts with IFIT2 and IFIT3 (By similarity). Interacts (via TPR repeats 4-7) with EEF1A1 (By similarity). Interacts (via TPR repeats 1-4) with RPL15 (By similarity). Interacts with STING1/MITA and disrupts its interaction with MAVS or TBK1 (By similarity). Interacts with EIF3C and EIF3E (By similarity).|||Cytoplasm|||ISGylated.|||Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism) (By similarity).|||Phosphorylated.|||RNA recognition is mediated by a convoluted intramolecular fold of the TPR repeats (TPR eddy), which scaffolds unique additional helices that form an RNA binding cleft. http://togogenome.org/gene/9541:PPIL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSL3 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9541:PELO ^@ http://purl.uniprot.org/uniprot/A0A2K5X8U8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||Interacts with PINK1, ABCE1 and CNOT4.|||May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs.|||Nucleus http://togogenome.org/gene/9541:ADA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3X6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.|||Secreted http://togogenome.org/gene/9541:PIM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2N0 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.|||Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. http://togogenome.org/gene/9541:LOC102119743 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:PCLO ^@ http://purl.uniprot.org/uniprot/A0A2K5TT71|||http://purl.uniprot.org/uniprot/A0A2K5U6Z3 ^@ Subcellular Location Annotation ^@ Presynaptic active zone http://togogenome.org/gene/9541:PPM1A ^@ http://purl.uniprot.org/uniprot/A0A2K5TTV9|||http://purl.uniprot.org/uniprot/A0A2K5TTX0|||http://purl.uniprot.org/uniprot/A0A7N9IDH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/9541:NSA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.|||nucleolus http://togogenome.org/gene/9541:DNAJC16 ^@ http://purl.uniprot.org/uniprot/A0A2K5X618|||http://purl.uniprot.org/uniprot/G7NU84 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:MALRD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUF6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:UBE2U ^@ http://purl.uniprot.org/uniprot/Q95LM1 ^@ Function|||PTM|||Similarity ^@ Autoubiquitinated in vitro in the presence of UBR5.|||Belongs to the ubiquitin-conjugating enzyme family.|||Catalyzes the covalent attachment of ubiquitin to other proteins. http://togogenome.org/gene/9541:F12 ^@ http://purl.uniprot.org/uniprot/A0A2K5V365 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:RPS6KA2 ^@ http://purl.uniprot.org/uniprot/Q9BE29 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9541:PPP2R5B ^@ http://purl.uniprot.org/uniprot/A0A2K5VWY4 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9541:DRD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:POLR3F ^@ http://purl.uniprot.org/uniprot/A0A2K5TYI7|||http://purl.uniprot.org/uniprot/G7PH18 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9541:NAT9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM11 ^@ Similarity ^@ Belongs to the acetyltransferase family. GNAT subfamily. http://togogenome.org/gene/9541:SNRPG ^@ http://purl.uniprot.org/uniprot/A0A2K5WTS0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/9541:TSR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU05 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.|||Belongs to the TDD superfamily. TSR3 family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:TOB2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZH4|||http://purl.uniprot.org/uniprot/G7PFN2 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9541:INPP5D ^@ http://purl.uniprot.org/uniprot/A0A2K5V4X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.|||Membrane http://togogenome.org/gene/9541:CYP7A1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XBY6|||http://purl.uniprot.org/uniprot/G7PBW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:CLDN20 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJE1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:ALDH1L2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJG4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.|||In the N-terminal section; belongs to the GART family. http://togogenome.org/gene/9541:LOC102124577 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SGSM3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2K8|||http://purl.uniprot.org/uniprot/A0A2K5V2L3 ^@ Similarity ^@ Belongs to the small G protein signaling modulator family. http://togogenome.org/gene/9541:CCR4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XLQ0|||http://purl.uniprot.org/uniprot/G7NYB7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:MST1R ^@ http://purl.uniprot.org/uniprot/A0A2K5VT07 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:SPDL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKG7|||http://purl.uniprot.org/uniprot/Q4R7H3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Spindly family.|||Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.|||Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect. Interacts with dynein intermediate chain and dynactin (DCTN1) (By similarity). Interacts with the catalytically active form of USP45 (By similarity).|||Monoubiquitinated with'Lys-48' linkage (By similarity). Deubiquitinated by USP45 (By similarity).|||Nucleus|||Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.|||Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Plays a role in cell migration (By similarity).|||centrosome|||kinetochore|||spindle pole http://togogenome.org/gene/9541:ATP5PD ^@ http://purl.uniprot.org/uniprot/A0A2K5U1U7|||http://purl.uniprot.org/uniprot/A0A2K5U1V5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase d subunit family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:PARVG ^@ http://purl.uniprot.org/uniprot/A0A2K5UUQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parvin family.|||Cell membrane|||cytoskeleton http://togogenome.org/gene/9541:RPL11 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHI1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL5 family. http://togogenome.org/gene/9541:EPHB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V953 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SMC2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XL17|||http://purl.uniprot.org/uniprot/G7PRT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC2 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9541:GUCY1A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZU5|||http://purl.uniprot.org/uniprot/G7P6G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/9541:UMPS ^@ http://purl.uniprot.org/uniprot/A0A2K5TYP5 ^@ Similarity ^@ In the C-terminal section; belongs to the OMP decarboxylase family.|||In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/9541:KCNJ10 ^@ http://purl.uniprot.org/uniprot/G7NWC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9541:RPP30 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTP1|||http://purl.uniprot.org/uniprot/G7PDJ0 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family. http://togogenome.org/gene/9541:SEC16B ^@ http://purl.uniprot.org/uniprot/A0A2K5TJL5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC16 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.|||SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. http://togogenome.org/gene/9541:ARGLU1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y9C1|||http://purl.uniprot.org/uniprot/G7PVP8 ^@ Similarity ^@ Belongs to the UPF0430 family. http://togogenome.org/gene/9541:ERAL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7T7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Membrane|||Mitochondrion inner membrane|||Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly. http://togogenome.org/gene/9541:JAKMIP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V362 ^@ Similarity ^@ Belongs to the JAKMIP family. http://togogenome.org/gene/9541:PDK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9541:DLL4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2Z5 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/9541:LOC102118953 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFS6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:PADI3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0T3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9541:LYZL4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZG4|||http://purl.uniprot.org/uniprot/G7NY74 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9541:LHX5 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2A3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PPIL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNT8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9541:LOC102123393 ^@ http://purl.uniprot.org/uniprot/Q25MM9|||http://purl.uniprot.org/uniprot/Q4R4I0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.|||Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes (By similarity).|||Associates with the I-kappa-B-kinase (IKK) core complex, composed of CHUK, IKBKB and IKBKG (By similarity). Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with TERF2 (but not TERF1) with its C-terminus. Interacts with SLX4/BTBD12. Interacts with TERF2; the interaction is direct (By similarity).|||Belongs to the RAP1 family.|||Chromosome|||Cytoplasm|||Homodimer.|||Nucleus|||telomere http://togogenome.org/gene/9541:MTERF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKI2 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9541:PANX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZS3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||S-nitrosylation inhibits channel currents and ATP release.|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/9541:LOC102122852 ^@ http://purl.uniprot.org/uniprot/A0A8J8YAJ5|||http://purl.uniprot.org/uniprot/G7NXM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9541:DCTN2 ^@ http://purl.uniprot.org/uniprot/I7GF37|||http://purl.uniprot.org/uniprot/I7GHC5 ^@ Function|||Similarity ^@ Belongs to the dynactin subunit 2 family.|||Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. http://togogenome.org/gene/9541:TCTA ^@ http://purl.uniprot.org/uniprot/A0A2K5W833|||http://purl.uniprot.org/uniprot/G8F3M0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCTA family.|||May be required for cellular fusion during osteoclastogenesis.|||Membrane http://togogenome.org/gene/9541:PSMG2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y8Q2|||http://purl.uniprot.org/uniprot/G7PWB8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PSMG2 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.|||Forms a heterodimer with PSMG1. http://togogenome.org/gene/9541:LOC102119524 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJT2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:HDC ^@ http://purl.uniprot.org/uniprot/A0A2K5UB23 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9541:PSMA5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XD69|||http://purl.uniprot.org/uniprot/G7NV55 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9541:GRN ^@ http://purl.uniprot.org/uniprot/A0A2K5TL59|||http://purl.uniprot.org/uniprot/A0A2K5TL62|||http://purl.uniprot.org/uniprot/Q4R529 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the granulin family.|||Secreted http://togogenome.org/gene/9541:HOXC6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XH79|||http://purl.uniprot.org/uniprot/G7PHW2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:IZUMO2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDM8 ^@ Similarity ^@ Belongs to the Izumo family. http://togogenome.org/gene/9541:DZIP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UR24|||http://purl.uniprot.org/uniprot/A0A2K5UR64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DZIP C2H2-type zinc-finger protein family.|||centriole|||cilium basal body http://togogenome.org/gene/9541:TNRC6B ^@ http://purl.uniprot.org/uniprot/A0A2K5WDJ8|||http://purl.uniprot.org/uniprot/G7PFL5 ^@ Similarity ^@ Belongs to the GW182 family. http://togogenome.org/gene/9541:BMT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYL0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the BMT2 family.|||Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.|||S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9541:B3GAT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5D6|||http://purl.uniprot.org/uniprot/A0A2K5U5G8|||http://purl.uniprot.org/uniprot/I7GHH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:CYP2S1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:UBA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLF3|||http://purl.uniprot.org/uniprot/A0A2K5WLL1|||http://purl.uniprot.org/uniprot/I7GJ84 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.|||Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. http://togogenome.org/gene/9541:BMP15 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8I1 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9541:LOC102132535 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/9541:THOC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0N2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THOC2 family.|||Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.|||Nucleus http://togogenome.org/gene/9541:FER ^@ http://purl.uniprot.org/uniprot/A0A2K5W0H6|||http://purl.uniprot.org/uniprot/A0A2K5W0I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.|||Cell membrane|||cytoskeleton http://togogenome.org/gene/9541:CFAP206 ^@ http://purl.uniprot.org/uniprot/G7P3K1|||http://purl.uniprot.org/uniprot/Q95JU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP206 family.|||Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (By similarity). Required for the establishment of radial spokes in sperm flagella (By similarity).|||cilium axoneme|||cilium basal body http://togogenome.org/gene/9541:ITGB7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VN98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Membrane http://togogenome.org/gene/9541:MPPED2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YKL0|||http://purl.uniprot.org/uniprot/G7PQH5 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/9541:TRPV6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXF2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:RPL23A ^@ http://purl.uniprot.org/uniprot/A0A2K5UIT1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9541:MYOC ^@ http://purl.uniprot.org/uniprot/A0A2K5VVC3 ^@ Caution|||Subcellular Location Annotation ^@ Endoplasmic reticulum|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion intermembrane space|||Mitochondrion outer membrane|||Rough endoplasmic reticulum|||cilium|||extracellular exosome|||extracellular matrix http://togogenome.org/gene/9541:PDCD11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJZ8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9541:TDO2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YL40|||http://purl.uniprot.org/uniprot/G7P6G7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer. Dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:RBM42 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEJ6|||http://purl.uniprot.org/uniprot/A0A2K5WEL2 ^@ Similarity ^@ Belongs to the RRM RBM42 family. http://togogenome.org/gene/9541:DNASE2 ^@ http://purl.uniprot.org/uniprot/I7GHD7 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/9541:PCYOX1L ^@ http://purl.uniprot.org/uniprot/A0A2K5WXH5 ^@ Similarity ^@ Belongs to the prenylcysteine oxidase family. http://togogenome.org/gene/9541:BTG3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX14 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9541:ACADS ^@ http://purl.uniprot.org/uniprot/A0A2K5U8F4|||http://purl.uniprot.org/uniprot/A0A2K5U8K3|||http://purl.uniprot.org/uniprot/A0A7N9DAV7 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9541:MED16 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ46 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 16 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9541:CDH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCE0 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Cell surface|||Membrane|||sarcolemma http://togogenome.org/gene/9541:C1H1orf43 ^@ http://purl.uniprot.org/uniprot/A0A2K5U459|||http://purl.uniprot.org/uniprot/A0A2K5U472|||http://purl.uniprot.org/uniprot/G8F6G6 ^@ Function|||Subcellular Location Annotation ^@ General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.|||Golgi apparatus|||Membrane|||Mitochondrion http://togogenome.org/gene/9541:CORO1A ^@ http://purl.uniprot.org/uniprot/A0A2K5URY2|||http://purl.uniprot.org/uniprot/G7Q0W5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat coronin family.|||Binds actin.|||Membrane|||cell cortex|||cytoskeleton|||phagosome membrane http://togogenome.org/gene/9541:PIGC ^@ http://purl.uniprot.org/uniprot/A0A2K5UID7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGC family.|||Membrane http://togogenome.org/gene/9541:STAT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:RIBC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U152|||http://purl.uniprot.org/uniprot/A0A8J8YKB8|||http://purl.uniprot.org/uniprot/G7Q2T0|||http://purl.uniprot.org/uniprot/Q4R698 ^@ Similarity ^@ Belongs to the RIB43A family. http://togogenome.org/gene/9541:ACOT8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UY94|||http://purl.uniprot.org/uniprot/A0A2K5UYC4 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9541:ASB10 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULT4|||http://purl.uniprot.org/uniprot/A0A2K5ULT9|||http://purl.uniprot.org/uniprot/G7P221 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:HOXB7 ^@ http://purl.uniprot.org/uniprot/A0A8J8XEE4|||http://purl.uniprot.org/uniprot/G7PU75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9541:FASLG ^@ http://purl.uniprot.org/uniprot/P63308 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis.|||Cytoplasmic form induces gene transcription inhibition.|||Cytoplasmic vesicle lumen|||Homotrimer. Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB1, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1.|||Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process.|||Lysosome lumen|||Monoubiquitinated.|||N-glycosylated. Glycosylation enhances apoptotic activity.|||Nucleus|||Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization.|||Secreted|||The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells. http://togogenome.org/gene/9541:CCL2 ^@ http://purl.uniprot.org/uniprot/G7PU21|||http://purl.uniprot.org/uniprot/P61274 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity).|||Belongs to the intercrine beta (chemokine CC) family.|||Monomer or homodimer; in equilibrium. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Interacts with TNFAIP6 (via Link domain).|||N-Glycosylated.|||Processing at the N-terminus can regulate receptor and target cell selectivity (By similarity). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (By similarity).|||Secreted http://togogenome.org/gene/9541:NOX5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X9B5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:MCL1 ^@ http://purl.uniprot.org/uniprot/I7G687 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Cytoplasm|||Membrane|||nucleoplasm http://togogenome.org/gene/9541:FOXR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WV77 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CCL24 ^@ http://purl.uniprot.org/uniprot/A0A7N9CBC6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:SLC25A11 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNM7|||http://purl.uniprot.org/uniprot/A0A8J8YAW0|||http://purl.uniprot.org/uniprot/G7PT97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:BOLA2B ^@ http://purl.uniprot.org/uniprot/A0A2K5WT49 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/9541:MCU ^@ http://purl.uniprot.org/uniprot/A0A2K5V9L4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCU (TC 1.A.77) family.|||Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).|||Membrane|||Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ZNF532 ^@ http://purl.uniprot.org/uniprot/A0A2K5UK98 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:BROX ^@ http://purl.uniprot.org/uniprot/A0A2K5X7F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BROX family.|||Membrane http://togogenome.org/gene/9541:FARSB ^@ http://purl.uniprot.org/uniprot/A0A2K5WM12|||http://purl.uniprot.org/uniprot/Q4R569 ^@ Similarity ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. http://togogenome.org/gene/9541:ADD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2Z1|||http://purl.uniprot.org/uniprot/A0A2K5U318|||http://purl.uniprot.org/uniprot/A0A2K5U319|||http://purl.uniprot.org/uniprot/A0A2K5U342|||http://purl.uniprot.org/uniprot/A0A7N9CQE1 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/9541:CPXM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Secreted http://togogenome.org/gene/9541:KHDC3L ^@ http://purl.uniprot.org/uniprot/A0A2K5WDT5 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9541:FLCN ^@ http://purl.uniprot.org/uniprot/A0A2K5WI89|||http://purl.uniprot.org/uniprot/A0A7N9DCK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the folliculin family.|||Lysosome membrane|||Membrane|||Nucleus|||centrosome|||cilium|||cytosol|||spindle http://togogenome.org/gene/9541:SLC6A7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9541:KDM4B ^@ http://purl.uniprot.org/uniprot/A0A2K5W6U8|||http://purl.uniprot.org/uniprot/A0A2K5W6X9 ^@ Similarity ^@ Belongs to the JHDM3 histone demethylase family. http://togogenome.org/gene/9541:PDXK ^@ http://purl.uniprot.org/uniprot/A0A2K5W0T2 ^@ Similarity ^@ Belongs to the pyridoxine kinase family. http://togogenome.org/gene/9541:SEZ6L2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJC1|||http://purl.uniprot.org/uniprot/A0A2K5VJI5|||http://purl.uniprot.org/uniprot/A0A2K5VJM4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:GRWD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQN8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:COG8 ^@ http://purl.uniprot.org/uniprot/A0A2K5U545 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG8 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:GANAB ^@ http://purl.uniprot.org/uniprot/A0A2K5VUH9|||http://purl.uniprot.org/uniprot/Q4R4N7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 31 family.|||Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia.|||Contains sialylated polysaccharide chains.|||Endoplasmic reticulum|||Golgi apparatus|||Heterodimer of a catalytic alpha subunit (GANAB) and a beta subunit (PRKCSH). Binds glycosylated PTPRC.|||Melanosome http://togogenome.org/gene/9541:MZT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQF6|||http://purl.uniprot.org/uniprot/G7PVI0 ^@ Function|||Similarity ^@ Belongs to the MOZART1 family.|||Required for gamma-tubulin complex recruitment to the centrosome. http://togogenome.org/gene/9541:RCCD1 ^@ http://purl.uniprot.org/uniprot/Q4R828 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Found in a complex with KDM8. Interacts (via N-terminus) with KDM8 (via N-terminus).|||Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8.|||Specifically hydroxylated (with R stereochemistry) at C-3 of ARG-141 by KDM8. http://togogenome.org/gene/9541:UBE2G2 ^@ http://purl.uniprot.org/uniprot/A0A7N9DD68 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:MAL ^@ http://purl.uniprot.org/uniprot/G7PMP6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TTC21B ^@ http://purl.uniprot.org/uniprot/A0A2K5VQM5 ^@ Similarity ^@ Belongs to the TTC21 family. http://togogenome.org/gene/9541:ARVCF ^@ http://purl.uniprot.org/uniprot/A0A2K5WL65|||http://purl.uniprot.org/uniprot/A0A2K5WL72 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.|||Cell membrane http://togogenome.org/gene/9541:CD40 ^@ http://purl.uniprot.org/uniprot/A0A2K5V581|||http://purl.uniprot.org/uniprot/A0A2K5V585|||http://purl.uniprot.org/uniprot/G7PG38 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:TIMM8B ^@ http://purl.uniprot.org/uniprot/G7PNT5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9541:VIPR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VP27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:MRPL27 ^@ http://purl.uniprot.org/uniprot/A0A7N9CWB8|||http://purl.uniprot.org/uniprot/I7GP21 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/9541:BHMT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQU0 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 zinc ion per subunit.|||Homotetramer.|||Involved in the regulation of homocysteine metabolism. http://togogenome.org/gene/9541:TMEM138 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQ93|||http://purl.uniprot.org/uniprot/G7PPY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM138 family.|||Membrane|||Required for ciliogenesis.|||Vacuole membrane|||cilium http://togogenome.org/gene/9541:ALDH3A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDK6|||http://purl.uniprot.org/uniprot/A0A2K5VDL2 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9541:KCTD19 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHQ7 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:PDHX ^@ http://purl.uniprot.org/uniprot/I7GJV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9541:VSNL1 ^@ http://purl.uniprot.org/uniprot/G7PLN2|||http://purl.uniprot.org/uniprot/Q4R5F7 ^@ Function|||Miscellaneous|||Similarity ^@ Belongs to the recoverin family.|||Probably binds three calcium ions.|||Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner. http://togogenome.org/gene/9541:CSF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ69 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GM-CSF family.|||Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.|||Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.|||Secreted http://togogenome.org/gene/9541:GAL ^@ http://purl.uniprot.org/uniprot/A0A2K5TWJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the galanin family.|||Secreted http://togogenome.org/gene/9541:EPHB1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XCA7|||http://purl.uniprot.org/uniprot/G7NXX9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||dendrite http://togogenome.org/gene/9541:FLAD1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYE5|||http://purl.uniprot.org/uniprot/G7NUJ8 ^@ Function|||Similarity ^@ Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.|||In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.|||In the N-terminal section; belongs to the MoaB/Mog family. http://togogenome.org/gene/9541:BIRC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:RGS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2L1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9541:HEXB ^@ http://purl.uniprot.org/uniprot/Q4R3S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 20 family.|||Lysosome http://togogenome.org/gene/9541:KCNS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDN3|||http://purl.uniprot.org/uniprot/G8F573 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:CASTOR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GATS family.|||cytosol http://togogenome.org/gene/9541:CLDN14 ^@ http://purl.uniprot.org/uniprot/A0A8J8XGB7|||http://purl.uniprot.org/uniprot/G7P110 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:IL18 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ84|||http://purl.uniprot.org/uniprot/A0A2K5TJ87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Cytoplasm|||Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted http://togogenome.org/gene/9541:SLC25A40 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGN4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:CMKLR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFJ8|||http://purl.uniprot.org/uniprot/Q95LH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane|||Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (By similarity). Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too. Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). http://togogenome.org/gene/9541:PC ^@ http://purl.uniprot.org/uniprot/A0A2K5VMP7 ^@ Function ^@ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. http://togogenome.org/gene/9541:SNX4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U538|||http://purl.uniprot.org/uniprot/A0A2K5U550 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9541:STAT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W636|||http://purl.uniprot.org/uniprot/A0A7N9CJU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:NPM3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAZ9|||http://purl.uniprot.org/uniprot/G7PDT5 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/9541:CFH ^@ http://purl.uniprot.org/uniprot/A0A2K5WYX9|||http://purl.uniprot.org/uniprot/A0A2K5WZ05 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:KCNJ1 ^@ http://purl.uniprot.org/uniprot/I7G6H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9541:ASB17 ^@ http://purl.uniprot.org/uniprot/Q95LR4 ^@ Domain|||Function|||Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family.|||May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.|||The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. http://togogenome.org/gene/9541:UBE2C ^@ http://purl.uniprot.org/uniprot/Q4R9D1 ^@ Function|||PTM|||Similarity|||Subunit ^@ Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.|||Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Its degradation plays a central role in APC/C regulation, allowing cyclin-A accumulation before S phase entry. APC/C substrates inhibit the autoubiquitination of UBE2C/UBCH10 but not its E2 function, hence APC/C remaining active until its substrates have been destroyed.|||Belongs to the ubiquitin-conjugating enzyme family.|||Component of the APC/C complex, composed of at least 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Within this complex, directly interacts with ANAPC2. http://togogenome.org/gene/9541:CYSTM1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CIF1|||http://purl.uniprot.org/uniprot/A0A8J8XDV0|||http://purl.uniprot.org/uniprot/G7P8G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYSTM1 family.|||Membrane http://togogenome.org/gene/9541:PTPN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6V0|||http://purl.uniprot.org/uniprot/A0A7N9I9Q8 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. http://togogenome.org/gene/9541:MSTN ^@ http://purl.uniprot.org/uniprot/G7PL15|||http://purl.uniprot.org/uniprot/Q95J86 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.|||Secreted|||Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase. http://togogenome.org/gene/9541:SLC39A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0P7|||http://purl.uniprot.org/uniprot/A0A7N9CFY9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102137006 ^@ http://purl.uniprot.org/uniprot/G8F3D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:HSBP1 ^@ http://purl.uniprot.org/uniprot/Q4R7N4 ^@ Similarity ^@ Belongs to the HSBP1 family. http://togogenome.org/gene/9541:LRP10 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6W2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PJVK ^@ http://purl.uniprot.org/uniprot/A0A8J8YQB6|||http://purl.uniprot.org/uniprot/G7PKX8 ^@ Similarity ^@ Belongs to the gasdermin family. http://togogenome.org/gene/9541:RNASE10 ^@ http://purl.uniprot.org/uniprot/A0A7N9CQW9 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9541:PSMD11 ^@ http://purl.uniprot.org/uniprot/Q4R330 ^@ Similarity ^@ Belongs to the proteasome subunit S9 family. http://togogenome.org/gene/9541:IFRD1 ^@ http://purl.uniprot.org/uniprot/Q4R6C6 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/9541:DEFB118 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:FABP9 ^@ http://purl.uniprot.org/uniprot/A0A7N9CGN7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:PTP4A2 ^@ http://purl.uniprot.org/uniprot/I7GK40 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9541:SRD5A1 ^@ http://purl.uniprot.org/uniprot/Q28891 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:PPP2R2C ^@ http://purl.uniprot.org/uniprot/A0A2K5U982|||http://purl.uniprot.org/uniprot/A0A2K5U9A3|||http://purl.uniprot.org/uniprot/A0A2K5U9C5 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9541:BRCA1 ^@ http://purl.uniprot.org/uniprot/A0A075VSV1|||http://purl.uniprot.org/uniprot/A0A2K5VLC7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Cytoplasm|||E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.|||Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1. Interacts with EXD2. Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme.|||Nucleus http://togogenome.org/gene/9541:ERGIC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJC9|||http://purl.uniprot.org/uniprot/A0A2K5WJF6|||http://purl.uniprot.org/uniprot/Q4R8X1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Forms homodimers (By similarity). May form a heteromeric complex composed of ERGIC1, ERGIC2 and ERGIC3 (By similarity). Within the complex, the interaction with ERGIC1 is direct (By similarity). Interacts with ERGIC1/ERGIC32 (By similarity). Interacts with ERGIC2, the interaction is required for the stable expression of both proteins (By similarity). Interacts with MARCHF2 (By similarity). Interacts with SERPINA1/alpha1-antitrypsin and HP/haptoglobin (By similarity).|||Golgi apparatus membrane|||Membrane|||Plays a role in transport between endoplasmic reticulum and Golgi.|||Possible role in transport between endoplasmic reticulum and Golgi. Positively regulates trafficking of the secretory proteins alpha1-antitrypsin/SERPINA1 and HP/haptoglobin (By similarity).|||cis-Golgi network membrane http://togogenome.org/gene/9541:DDB2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDL2|||http://purl.uniprot.org/uniprot/G7PQA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DDB2/WDR76 family.|||Nucleus http://togogenome.org/gene/9541:EML6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat EMAP family.|||May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.|||cytoskeleton http://togogenome.org/gene/9541:TMLHE ^@ http://purl.uniprot.org/uniprot/A0A2K5TW47 ^@ Similarity ^@ Belongs to the gamma-BBH/TMLD family. http://togogenome.org/gene/9541:APOL4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ14 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9541:NOS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UA21|||http://purl.uniprot.org/uniprot/A0A2K5UA38 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOS family.|||Binds 1 FAD.|||Binds 1 FMN.|||Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.|||dendritic spine|||sarcolemma http://togogenome.org/gene/9541:APOH ^@ http://purl.uniprot.org/uniprot/A0A2K5V4B0 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:ZDHHC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3H3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:GPHA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDU0 ^@ Caution|||Similarity ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:NEK9 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5Y8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. http://togogenome.org/gene/9541:LOC102124735 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVV0|||http://purl.uniprot.org/uniprot/G7P5K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9541:PHF10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VP05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAYP family.|||Nucleus http://togogenome.org/gene/9541:PRKRA ^@ http://purl.uniprot.org/uniprot/A0A2K5WED7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRKRA family.|||perinuclear region http://togogenome.org/gene/9541:TMEM14A ^@ http://purl.uniprot.org/uniprot/A0A2K5UQD5 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9541:APH1B ^@ http://purl.uniprot.org/uniprot/Q4R5U7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/9541:LOC102115663 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVR9 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/9541:OXA1L ^@ http://purl.uniprot.org/uniprot/A0A2K5UG80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/9541:PPP2R5E ^@ http://purl.uniprot.org/uniprot/A0A2K5TKQ9 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9541:OGFOD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFP1 ^@ Similarity ^@ Belongs to the TPA1 family. http://togogenome.org/gene/9541:DERL1 ^@ http://purl.uniprot.org/uniprot/I7GMH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/9541:TRAPPC2 ^@ http://purl.uniprot.org/uniprot/I7G790 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/9541:GPR158 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PHKG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSB4|||http://purl.uniprot.org/uniprot/A0A2K5VSE0 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/9541:EME2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UK36 ^@ Similarity ^@ Belongs to the EME1/MMS4 family. http://togogenome.org/gene/9541:CASQ1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/9541:TRHR ^@ http://purl.uniprot.org/uniprot/A0A2K5UTF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/9541:GRK3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CLH8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9541:CTBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/9541:POLG ^@ http://purl.uniprot.org/uniprot/A0A2K5W0R5 ^@ Function|||Subcellular Location Annotation ^@ Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.|||mitochondrion nucleoid http://togogenome.org/gene/9541:ZC3HAV1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTS9 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9541:HBS1L ^@ http://purl.uniprot.org/uniprot/A0A2K5WCH4|||http://purl.uniprot.org/uniprot/A0A2K5WCN9 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. http://togogenome.org/gene/9541:UXT ^@ http://purl.uniprot.org/uniprot/A0A2K5TZQ7|||http://purl.uniprot.org/uniprot/G7Q2L7 ^@ Similarity ^@ Belongs to the UXT family. http://togogenome.org/gene/9541:TET1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM86 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Chromosome|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/9541:TMSB15A ^@ http://purl.uniprot.org/uniprot/A0A8J8XD17|||http://purl.uniprot.org/uniprot/G7Q3A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9541:LOC102121924 ^@ http://purl.uniprot.org/uniprot/G7PQ25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:MRPL16 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZC6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/9541:ARSK ^@ http://purl.uniprot.org/uniprot/A0A2K5V9L1 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9541:CDS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X708 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Membrane http://togogenome.org/gene/9541:STMN1 ^@ http://purl.uniprot.org/uniprot/A0A805RLD7|||http://purl.uniprot.org/uniprot/Q25QD1|||http://purl.uniprot.org/uniprot/Q4R712 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the stathmin family.|||Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST (By similarity).|||Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).|||Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization. Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity (By similarity).|||cytoskeleton http://togogenome.org/gene/9541:PIERCE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEM4|||http://purl.uniprot.org/uniprot/G7PBI9 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.|||cilium axoneme http://togogenome.org/gene/9541:STX18 ^@ http://purl.uniprot.org/uniprot/A0A2K5VG85|||http://purl.uniprot.org/uniprot/A0A2K5VGH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Endoplasmic reticulum membrane|||Membrane|||Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. http://togogenome.org/gene/9541:CCS ^@ http://purl.uniprot.org/uniprot/A0A2K5X1C8 ^@ Similarity ^@ In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family. http://togogenome.org/gene/9541:LOC102136846 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIF5 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9541:ANAPC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKI1 ^@ Function|||Similarity ^@ Belongs to the APC4 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/9541:LOC102115347 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRZ2 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9541:LOC102125256 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6X8 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9541:SEC23B ^@ http://purl.uniprot.org/uniprot/A0A8J8XJI6|||http://purl.uniprot.org/uniprot/Q9BE95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9541:MAFB ^@ http://purl.uniprot.org/uniprot/Q2PFS4 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context (By similarity). Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity).|||Belongs to the bZIP family. Maf subfamily.|||Homodimer or heterodimer with other bHLH-Zip transcription factors. Binds DNA as a homodimer or a heterodimer. Forms homodimers and heterodimers with FOS, FOSB and FOSL2, but not with JUN proteins (JUN, JUNB and JUND). Interacts with PAX6; the interaction is direct. Interacts with ETS1 and LRP1. Interacts with the intracellular cytoplasmic domain of LRP1 (LRPICD); the interaction results in a moderate reduction of MAFB transcriptional potential (By similarity).|||Nucleus|||Sumoylated. Sumoylation on Lys-32 and Lys-297 stimulates its transcriptional repression activity and promotes macrophage differentiation from myeloid progenitors (By similarity).|||The leucine-zipper domain is involved in the interaction with LRPICD. http://togogenome.org/gene/9541:TCEA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/9541:MMGT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4Z9|||http://purl.uniprot.org/uniprot/G7Q1S3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane magnesium transporter (TC 1.A.67) family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport. http://togogenome.org/gene/9541:MED27 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9H7|||http://purl.uniprot.org/uniprot/A0A8J8YJW3|||http://purl.uniprot.org/uniprot/G7PRA7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 27 family.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9541:ASB11 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1E1|||http://purl.uniprot.org/uniprot/A0A2K5W1E6 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:PLAG1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XP54|||http://purl.uniprot.org/uniprot/G7PBV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9541:SLC25A45 ^@ http://purl.uniprot.org/uniprot/A0A2K5VU79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:NUP133 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin Nup133 family.|||nuclear pore complex http://togogenome.org/gene/9541:PRPF38B ^@ http://purl.uniprot.org/uniprot/A0A2K5UDD8|||http://purl.uniprot.org/uniprot/G8F4J3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||May be required for pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9541:FAM110A ^@ http://purl.uniprot.org/uniprot/A0A2K5UP52 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9541:GAP43 ^@ http://purl.uniprot.org/uniprot/Q25G41|||http://purl.uniprot.org/uniprot/Q95K78 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neuromodulin family.|||Cell membrane|||Cytoplasm|||Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (By similarity). Interacts (via IQ domain) with calmodulin (By similarity). Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence (By similarity).|||Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.|||Membrane|||Palmitoylated by ZDHHC3 (By similarity). Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2 (By similarity).|||Palmitoylated. Palmitoylation is essential for plasma membrane association.|||Perikaryon|||Phosphorylated (By similarity). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity).|||Synapse|||This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity).|||This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.|||axon|||dendrite|||filopodium membrane|||growth cone membrane http://togogenome.org/gene/9541:LOC102141871 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102135781 ^@ http://purl.uniprot.org/uniprot/Q07276 ^@ Function|||Similarity ^@ Belongs to the peptidase S1 family. Kallikrein subfamily.|||Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. http://togogenome.org/gene/9541:MSR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWE2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ADAMTS6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPD3 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:DSE ^@ http://purl.uniprot.org/uniprot/A0A2K5V7G5 ^@ Similarity ^@ Belongs to the dermatan-sulfate isomerase family. http://togogenome.org/gene/9541:SPIN3 ^@ http://purl.uniprot.org/uniprot/G8F4G1 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/9541:TM7SF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVI7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TEF ^@ http://purl.uniprot.org/uniprot/A0A2K5V8M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9541:LOC102115644 ^@ http://purl.uniprot.org/uniprot/A0A2K5WP84 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/9541:OLFML3 ^@ http://purl.uniprot.org/uniprot/I7GHM4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OLFML3 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:TSG101 ^@ http://purl.uniprot.org/uniprot/A0A8J8YL06|||http://purl.uniprot.org/uniprot/G7PQL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.|||Endosome membrane|||Membrane http://togogenome.org/gene/9541:EXT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VG65|||http://purl.uniprot.org/uniprot/A0A2K5VGE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:CLSTN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1F9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:TMPRSS6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAP0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:ARHGEF7 ^@ http://purl.uniprot.org/uniprot/A0A2K5W795|||http://purl.uniprot.org/uniprot/A0A2K5W7F8|||http://purl.uniprot.org/uniprot/A0A2K5W7G6|||http://purl.uniprot.org/uniprot/A0A2K5W7L1 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/9541:LOC102133777 ^@ http://purl.uniprot.org/uniprot/A0A8J8XNB8|||http://purl.uniprot.org/uniprot/G7PII2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9541:KCNAB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8Y2|||http://purl.uniprot.org/uniprot/A0A2K5V8Z8|||http://purl.uniprot.org/uniprot/A0A2K5V907|||http://purl.uniprot.org/uniprot/A0A7N9DCB8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Cytoplasm|||Membrane|||Monomer.|||axon|||cytoskeleton|||synaptosome http://togogenome.org/gene/9541:ALCAM ^@ http://purl.uniprot.org/uniprot/Q4R603 ^@ Subcellular Location Annotation ^@ Cell membrane|||axon|||dendrite http://togogenome.org/gene/9541:ANXA5 ^@ http://purl.uniprot.org/uniprot/Q4R4H7 ^@ Domain|||Function|||PTM|||Similarity|||Subunit ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Monomer. Binds ATRX and EIF5B (By similarity).|||S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.|||The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.|||This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. http://togogenome.org/gene/9541:AFG1L ^@ http://purl.uniprot.org/uniprot/A0A2K5WWA7|||http://purl.uniprot.org/uniprot/A0A7N9CWL8|||http://purl.uniprot.org/uniprot/A0A7N9DCI3|||http://purl.uniprot.org/uniprot/G7P3Q5 ^@ Similarity ^@ Belongs to the AFG1 ATPase family. http://togogenome.org/gene/9541:MFSD14A ^@ http://purl.uniprot.org/uniprot/A0A2K5WYA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9541:LOC101925870 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5W4|||http://purl.uniprot.org/uniprot/A0A8J8YP37|||http://purl.uniprot.org/uniprot/G7PBY9|||http://purl.uniprot.org/uniprot/I7GDF2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9541:UNC13D ^@ http://purl.uniprot.org/uniprot/A0A2K5UK80 ^@ Similarity ^@ Belongs to the unc-13 family. http://togogenome.org/gene/9541:KCNJ5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.|||Membrane http://togogenome.org/gene/9541:LRRC51 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTJ8|||http://purl.uniprot.org/uniprot/A0A8J8XIN6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:EPHA2 ^@ http://purl.uniprot.org/uniprot/Q1KL86 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autophosphorylates. Phosphorylated on tyrosine upon binding and activation by EFNA1. Phosphorylated residues Tyr-588 and Tyr-594 are required for binding VAV2 and VAV3 while phosphorylated residues Tyr-735 and Tyr-930 are required for binding PI3-kinase p85 subunit (PIK3R1, PIK3R2 or PIK3R3). These phosphorylated residues are critical for recruitment of VAV2 and VAV3 and PI3-kinase p85 subunit which transduce downstream signaling to activate RAC1 GTPase and cell migration. Dephosphorylation of Tyr-930 by PTPRF prevents the interaction of EPHA2 with NCK1. Phosphorylated at Ser-897 by PKB; serum-induced phosphorylation which targets EPHA2 to the cell leading edge and stimulates cell migration. Phosphorylation by PKB is inhibited by EFNA1-activated EPHA2 which regulates PKB activity via a reciprocal regulatory loop. Phosphorylated at Ser-897 in response to TNF by RPS6KA1 and RPS6KA3; RPS6KA-EPHA2 signaling pathway controls cell migration. Phosphorylated at Ser-897 by PKA; blocks cell retraction induced by EPHA2 kinase activity. Dephosphorylated by ACP1.|||Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.|||Cell membrane|||Homodimer. Interacts with SLA. Interacts (phosphorylated form) with VAV2, VAV3 and PI3-kinase p85 subunit (PIK3R1, PIK3R2 or PIK3R3); critical for the EFNA1-induced activation of RAC1 which stimulates cell migration. Interacts with INPPL1; regulates activated EPHA2 endocytosis and degradation. Interacts (inactivated form) with PTK2/FAK1 and interacts (EFNA1 ligand-activated form) with PTPN11; regulates integrin-mediated adhesion. Interacts with ARHGEF16, DOCK4 and ELMO2; mediates ligand-independent activation of RAC1 which stimulates cell migration. Interacts with CLDN4; phosphorylates CLDN4 and may regulate tight junctions. Interacts with ACP1. Interacts with ANKS1A. Interacts with CEMIP. Interacts with NCK1; may regulate EPHA2 activity in cell migration and adhesion.Interacts with TIMD4 (By similarity).|||Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity).|||Ubiquitinated by CHIP/STUB1. Ubiquitination is regulated by the HSP90 chaperone and regulates the receptor stability and activity through proteasomal degradation. ANKS1A prevents ubiquitination and degradation (By similarity).|||focal adhesion|||lamellipodium membrane|||ruffle membrane http://togogenome.org/gene/9541:EP300 ^@ http://purl.uniprot.org/uniprot/A0A8J8XI68|||http://purl.uniprot.org/uniprot/G7PFM4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:IQCD ^@ http://purl.uniprot.org/uniprot/A0A2K5TTU4|||http://purl.uniprot.org/uniprot/G7PIR0|||http://purl.uniprot.org/uniprot/Q4R8Y5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DRC10 family.|||Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.|||Component of the nexin-dynein regulatory complex (N-DRC). Interacts with CFAP52 (By similarity).|||flagellum axoneme http://togogenome.org/gene/9541:COQ10A ^@ http://purl.uniprot.org/uniprot/A0A2K5UKY6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/9541:PDCD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM63 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/9541:ENTPD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8Y7 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9541:PPP1R9B ^@ http://purl.uniprot.org/uniprot/A0A2K5WX32 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:MRPL23 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGW3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9541:NTAQ1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRW2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NTAQ1 family.|||Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.|||Monomer. http://togogenome.org/gene/9541:CD109 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNN1 ^@ Similarity ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. http://togogenome.org/gene/9541:TAS2R4 ^@ http://purl.uniprot.org/uniprot/A0A7N9IHD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane|||cilium membrane http://togogenome.org/gene/9541:FGFR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1U0|||http://purl.uniprot.org/uniprot/A0A2K5V1U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:EID2B ^@ http://purl.uniprot.org/uniprot/G7PXK1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CAMK1G ^@ http://purl.uniprot.org/uniprot/A0A2K5U137|||http://purl.uniprot.org/uniprot/G7NUP1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:HR ^@ http://purl.uniprot.org/uniprot/A0A2K5U4Q6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:RPLP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6Z8 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/9541:SERPINI1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5L9|||http://purl.uniprot.org/uniprot/G7NZG9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:NSFL1C ^@ http://purl.uniprot.org/uniprot/A0A2K5VJE4|||http://purl.uniprot.org/uniprot/A0A2K5VJS2 ^@ Subcellular Location Annotation|||Subunit ^@ Golgi stack|||Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP. http://togogenome.org/gene/9541:PFAS ^@ http://purl.uniprot.org/uniprot/A0A2K5U000 ^@ Similarity ^@ In the N-terminal section; belongs to the FGAMS family. http://togogenome.org/gene/9541:MAOB ^@ http://purl.uniprot.org/uniprot/A0A2K5TQG7|||http://purl.uniprot.org/uniprot/A0A2K5TQH2 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9541:ENTPD4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJS7 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9541:VTA1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YMP1|||http://purl.uniprot.org/uniprot/G7P314 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTA1 family.|||Cytoplasm|||Endosome membrane|||Membrane