http://togogenome.org/gene/985053:VMUT_RS06095 ^@ http://purl.uniprot.org/uniprot/F0QYE8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS08655 ^@ http://purl.uniprot.org/uniprot/F0QUG7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.|||Belongs to the Holliday junction resolvase Hjc family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer. http://togogenome.org/gene/985053:VMUT_RS01410 ^@ http://purl.uniprot.org/uniprot/F0QTD8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/985053:VMUT_RS02355 ^@ http://purl.uniprot.org/uniprot/F0QUC1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/985053:VMUT_RS10040 ^@ http://purl.uniprot.org/uniprot/F0QVW9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/985053:VMUT_RS07215 ^@ http://purl.uniprot.org/uniprot/F0QT15 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/985053:VMUT_RS09370 ^@ http://purl.uniprot.org/uniprot/F0QVB6 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/985053:VMUT_RS03945 ^@ http://purl.uniprot.org/uniprot/F0QW50 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/985053:VMUT_RS01500 ^@ http://purl.uniprot.org/uniprot/F0QTF4 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/985053:VMUT_RS02315 ^@ http://purl.uniprot.org/uniprot/F0QUB3 ^@ Function|||Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.|||Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway. http://togogenome.org/gene/985053:VMUT_RS00050 ^@ http://purl.uniprot.org/uniprot/F0QYU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/985053:VMUT_RS09095 ^@ http://purl.uniprot.org/uniprot/F0QUY0 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/985053:VMUT_RS09000 ^@ http://purl.uniprot.org/uniprot/F0QUW0 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. RfcS subfamily. http://togogenome.org/gene/985053:VMUT_RS11490 ^@ http://purl.uniprot.org/uniprot/F0QXK6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/985053:VMUT_RS03900 ^@ http://purl.uniprot.org/uniprot/F0QW42 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/985053:VMUT_RS11700 ^@ http://purl.uniprot.org/uniprot/F0QXX5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS10775 ^@ http://purl.uniprot.org/uniprot/F0QWR5 ^@ Function|||Similarity ^@ Belongs to the eIF-6 family.|||Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. http://togogenome.org/gene/985053:VMUT_RS00315 ^@ http://purl.uniprot.org/uniprot/F0QSC6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS07365 ^@ http://purl.uniprot.org/uniprot/F0QT45 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS09275 ^@ http://purl.uniprot.org/uniprot/F0QV96 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.|||Binds to the 23S rRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/985053:VMUT_RS06185 ^@ http://purl.uniprot.org/uniprot/F0QYG6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/985053:VMUT_RS03305 ^@ http://purl.uniprot.org/uniprot/F0QVJ5 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/985053:VMUT_RS03845 ^@ http://purl.uniprot.org/uniprot/F0QW30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Membrane http://togogenome.org/gene/985053:VMUT_RS03750 ^@ http://purl.uniprot.org/uniprot/F0QW12 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/985053:VMUT_RS09205 ^@ http://purl.uniprot.org/uniprot/F0QV02 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/985053:VMUT_RS00535 ^@ http://purl.uniprot.org/uniprot/F0QSG9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS02245 ^@ http://purl.uniprot.org/uniprot/F0QUA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm http://togogenome.org/gene/985053:VMUT_RS02140 ^@ http://purl.uniprot.org/uniprot/F0QU81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/985053:VMUT_RS04680 ^@ http://purl.uniprot.org/uniprot/F0QWZ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. Probably involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.|||Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA. http://togogenome.org/gene/985053:VMUT_RS02250 ^@ http://purl.uniprot.org/uniprot/F0QUA1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6A family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/985053:VMUT_RS05850 ^@ http://purl.uniprot.org/uniprot/F0QY96 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt4 family.|||Heterodimer composed of Spt4 and Spt5.|||Stimulates transcription elongation. http://togogenome.org/gene/985053:VMUT_RS09010 ^@ http://purl.uniprot.org/uniprot/F0QUW2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS01915 ^@ http://purl.uniprot.org/uniprot/F0QTW0 ^@ Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family. http://togogenome.org/gene/985053:VMUT_RS01540 ^@ http://purl.uniprot.org/uniprot/F0QTG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal histone HMF family.|||Chromosome|||Cytoplasm http://togogenome.org/gene/985053:VMUT_RS04685 ^@ http://purl.uniprot.org/uniprot/F0QWZ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/985053:VMUT_RS04105 ^@ http://purl.uniprot.org/uniprot/F0QWF8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS04210 ^@ http://purl.uniprot.org/uniprot/F0QWH7 ^@ Similarity ^@ In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family. http://togogenome.org/gene/985053:VMUT_RS08775 ^@ http://purl.uniprot.org/uniprot/F0QUJ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/985053:VMUT_RS04895 ^@ http://purl.uniprot.org/uniprot/F0QXB8 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/985053:VMUT_RS06075 ^@ http://purl.uniprot.org/uniprot/F0QYE4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS06205 ^@ http://purl.uniprot.org/uniprot/F0QYH0 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/985053:VMUT_RS06510 ^@ http://purl.uniprot.org/uniprot/F0QYN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/985053:VMUT_RS11065 ^@ http://purl.uniprot.org/uniprot/F0QX50 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/985053:VMUT_RS06820 ^@ http://purl.uniprot.org/uniprot/F0QSK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/985053:VMUT_RS07095 ^@ http://purl.uniprot.org/uniprot/F0QSR3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/985053:VMUT_RS08555 ^@ http://purl.uniprot.org/uniprot/F0QUE8 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/985053:VMUT_RS09280 ^@ http://purl.uniprot.org/uniprot/F0QV97 ^@ Function ^@ Probably involved in the biogenesis of the ribosome. http://togogenome.org/gene/985053:VMUT_RS11650 ^@ http://purl.uniprot.org/uniprot/F0QXN6 ^@ Cofactor ^@ Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/985053:VMUT_RS03255 ^@ http://purl.uniprot.org/uniprot/F0QVI5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/985053:VMUT_RS01605 ^@ http://purl.uniprot.org/uniprot/F0QTQ2 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/985053:VMUT_RS08335 ^@ http://purl.uniprot.org/uniprot/F0QU33 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/985053:VMUT_RS06985 ^@ http://purl.uniprot.org/uniprot/F0QSP1 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/985053:VMUT_RS07245 ^@ http://purl.uniprot.org/uniprot/F0QT21 ^@ Function|||Similarity ^@ Belongs to the THEP1 NTPase family.|||Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency. http://togogenome.org/gene/985053:VMUT_RS10870 ^@ http://purl.uniprot.org/uniprot/F0QWT3 ^@ Similarity ^@ Belongs to the complex I subunit 3 family. http://togogenome.org/gene/985053:VMUT_RS05895 ^@ http://purl.uniprot.org/uniprot/F0QYA5 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS03950 ^@ http://purl.uniprot.org/uniprot/F0QW51 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 38 family. http://togogenome.org/gene/985053:VMUT_RS10645 ^@ http://purl.uniprot.org/uniprot/F0QWN9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds at least 2 Zn(2+) per subunit.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/985053:VMUT_RS04060 ^@ http://purl.uniprot.org/uniprot/F0QWE9 ^@ Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Toxic component of a toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/985053:VMUT_RS04650 ^@ http://purl.uniprot.org/uniprot/F0QWZ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAC-alpha family.|||Contacts the emerging nascent chain on the ribosome.|||Homodimer. Interacts with the ribosome. Binds ribosomal RNA. http://togogenome.org/gene/985053:VMUT_RS00320 ^@ http://purl.uniprot.org/uniprot/F0QSC7 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/985053:VMUT_RS04975 ^@ http://purl.uniprot.org/uniprot/F0QXD3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/985053:VMUT_RS03925 ^@ http://purl.uniprot.org/uniprot/F0QW46 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Cytoplasm|||Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.|||Part of the 50S ribosomal subunit. Probably part of the RNase P complex. http://togogenome.org/gene/985053:VMUT_RS01070 ^@ http://purl.uniprot.org/uniprot/F0QSZ9 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. http://togogenome.org/gene/985053:VMUT_RS03050 ^@ http://purl.uniprot.org/uniprot/F0QV64 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/985053:VMUT_RS05060 ^@ http://purl.uniprot.org/uniprot/F0QXF0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/985053:VMUT_RS07935 ^@ http://purl.uniprot.org/uniprot/F0QTM8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family. LysK subfamily.|||Binds 2 Zn(2+) or Co(2+) ions per subunit.|||Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.|||Cytoplasm http://togogenome.org/gene/985053:VMUT_RS01610 ^@ http://purl.uniprot.org/uniprot/F0QTQ3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. http://togogenome.org/gene/985053:VMUT_RS10850 ^@ http://purl.uniprot.org/uniprot/F0QWS9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/985053:VMUT_RS07910 ^@ http://purl.uniprot.org/uniprot/F0QTM4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.|||Cytoplasm|||Involved in both the arginine and lysine biosynthetic pathways.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS12020 ^@ http://purl.uniprot.org/uniprot/F0QY28 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the FBP aldolase/phosphatase family.|||Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).|||Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.|||Homooctamer; dimer of tetramers. http://togogenome.org/gene/985053:VMUT_RS08005 ^@ http://purl.uniprot.org/uniprot/F0QTP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/985053:VMUT_RS09045 ^@ http://purl.uniprot.org/uniprot/F0QUX0 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/985053:VMUT_RS10560 ^@ http://purl.uniprot.org/uniprot/F0QWM2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.|||Belongs to the histone-like Alba family.|||Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.|||Chromosome|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/985053:VMUT_RS09415 ^@ http://purl.uniprot.org/uniprot/F0QVC5 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/985053:VMUT_RS04675 ^@ http://purl.uniprot.org/uniprot/F0QWZ7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/985053:VMUT_RS04345 ^@ http://purl.uniprot.org/uniprot/F0QWK4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/985053:VMUT_RS09980 ^@ http://purl.uniprot.org/uniprot/F0QVV7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS04435 ^@ http://purl.uniprot.org/uniprot/F0QWU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.|||Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.|||Cytoplasm http://togogenome.org/gene/985053:VMUT_RS07210 ^@ http://purl.uniprot.org/uniprot/F0QT14 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/985053:VMUT_RS03730 ^@ http://purl.uniprot.org/uniprot/F0QW09 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Potential transporter for phosphate. http://togogenome.org/gene/985053:VMUT_RS07550 ^@ http://purl.uniprot.org/uniprot/F0QT81 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.|||Nucleus|||Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure. http://togogenome.org/gene/985053:VMUT_RS10615 ^@ http://purl.uniprot.org/uniprot/F0QWN3 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the thiamine-phosphate synthase family.|||Binds 1 Mg(2+) ion per subunit.|||Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS06800 ^@ http://purl.uniprot.org/uniprot/F0QYT7 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/985053:VMUT_RS03195 ^@ http://purl.uniprot.org/uniprot/F0QVH3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS11050 ^@ http://purl.uniprot.org/uniprot/F0QX47 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/985053:VMUT_RS04855 ^@ http://purl.uniprot.org/uniprot/F0QXB1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA. http://togogenome.org/gene/985053:VMUT_RS06610 ^@ http://purl.uniprot.org/uniprot/F0QYP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-archaeol synthase family.|||Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.|||Cell membrane http://togogenome.org/gene/985053:VMUT_RS01680 ^@ http://purl.uniprot.org/uniprot/F0QTR5 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/985053:VMUT_RS01590 ^@ http://purl.uniprot.org/uniprot/F0QTP9 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the archaeosine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS04050 ^@ http://purl.uniprot.org/uniprot/F0QWE7 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/985053:VMUT_RS06755 ^@ http://purl.uniprot.org/uniprot/F0QYS8 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/985053:VMUT_RS11870 ^@ http://purl.uniprot.org/uniprot/F0QY02 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/985053:VMUT_RS00610 ^@ http://purl.uniprot.org/uniprot/F0QSI3 ^@ Caution|||Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS06540 ^@ http://purl.uniprot.org/uniprot/F0QYN5 ^@ Similarity ^@ Belongs to the DeoC/FbaB aldolase family. http://togogenome.org/gene/985053:VMUT_RS00925 ^@ http://purl.uniprot.org/uniprot/F0QSX2 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/985053:VMUT_RS06950 ^@ http://purl.uniprot.org/uniprot/F0QSN4 ^@ Similarity ^@ Belongs to the HepT RNase toxin family. http://togogenome.org/gene/985053:VMUT_RS02835 ^@ http://purl.uniprot.org/uniprot/F0QV23 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/985053:VMUT_RS07085 ^@ http://purl.uniprot.org/uniprot/F0QSR1 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/985053:VMUT_RS10145 ^@ http://purl.uniprot.org/uniprot/F0QW67 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/985053:VMUT_RS10150 ^@ http://purl.uniprot.org/uniprot/F0QW68 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/985053:VMUT_RS03560 ^@ http://purl.uniprot.org/uniprot/F0QVX4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL24 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14. http://togogenome.org/gene/985053:VMUT_RS01010 ^@ http://purl.uniprot.org/uniprot/F0QSY7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/985053:VMUT_RS08170 ^@ http://purl.uniprot.org/uniprot/F0QU02 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS02500 ^@ http://purl.uniprot.org/uniprot/F0QUM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/985053:VMUT_RS09535 ^@ http://purl.uniprot.org/uniprot/F0QVE7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/985053:VMUT_RS10910 ^@ http://purl.uniprot.org/uniprot/F0QX19 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSL4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. http://togogenome.org/gene/985053:VMUT_RS02395 ^@ http://purl.uniprot.org/uniprot/F0QUK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/985053:VMUT_RS09005 ^@ http://purl.uniprot.org/uniprot/F0QUW1 ^@ Function|||Similarity ^@ Belongs to the TFIIB family.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/985053:VMUT_RS03390 ^@ http://purl.uniprot.org/uniprot/F0QVL1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/985053:VMUT_RS06850 ^@ http://purl.uniprot.org/uniprot/F0QSL3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. http://togogenome.org/gene/985053:VMUT_RS06150 ^@ http://purl.uniprot.org/uniprot/F0QYF9 ^@ Similarity ^@ Belongs to the HepT RNase toxin family. http://togogenome.org/gene/985053:VMUT_RS03965 ^@ http://purl.uniprot.org/uniprot/F0QWD0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/985053:VMUT_RS02470 ^@ http://purl.uniprot.org/uniprot/F0QUM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/985053:VMUT_RS08665 ^@ http://purl.uniprot.org/uniprot/F0QUG9 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/985053:VMUT_RS02040 ^@ http://purl.uniprot.org/uniprot/F0QU61 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/985053:VMUT_RS04165 ^@ http://purl.uniprot.org/uniprot/F0QWH0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/985053:VMUT_RS09985 ^@ http://purl.uniprot.org/uniprot/F0QVV8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/985053:VMUT_RS11480 ^@ http://purl.uniprot.org/uniprot/F0QXK4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS00025 ^@ http://purl.uniprot.org/uniprot/F0QYU1 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/985053:VMUT_RS09240 ^@ http://purl.uniprot.org/uniprot/F0QV89 ^@ Caution|||Function|||Similarity ^@ Belongs to the Nre family.|||Involved in DNA damage repair.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS06255 ^@ http://purl.uniprot.org/uniprot/F0QYI0 ^@ Similarity ^@ Belongs to the UDPGP type 2 family. http://togogenome.org/gene/985053:VMUT_RS10170 ^@ http://purl.uniprot.org/uniprot/F0QW72 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/985053:VMUT_RS00680 ^@ http://purl.uniprot.org/uniprot/F0QSJ6 ^@ Similarity ^@ Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/985053:VMUT_RS02005 ^@ http://purl.uniprot.org/uniprot/F0QU54 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/985053:VMUT_RS07390 ^@ http://purl.uniprot.org/uniprot/F0QT50 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/985053:VMUT_RS04350 ^@ http://purl.uniprot.org/uniprot/F0QWK5 ^@ Subcellular Location Annotation ^@ Encapsulin nanocompartment http://togogenome.org/gene/985053:VMUT_RS03180 ^@ http://purl.uniprot.org/uniprot/F0QVH0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/985053:VMUT_RS10630 ^@ http://purl.uniprot.org/uniprot/F0QWN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/985053:VMUT_RS07785 ^@ http://purl.uniprot.org/uniprot/F0QTK1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS06090 ^@ http://purl.uniprot.org/uniprot/F0QYE7 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/985053:VMUT_RS03285 ^@ http://purl.uniprot.org/uniprot/F0QVJ1 ^@ Similarity ^@ Belongs to the ETF alpha-subunit/FixB family. http://togogenome.org/gene/985053:VMUT_RS06200 ^@ http://purl.uniprot.org/uniprot/F0QYG9 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/985053:VMUT_RS03445 ^@ http://purl.uniprot.org/uniprot/F0QVM3 ^@ Function|||Similarity ^@ Belongs to the GTP-dependent DPCK family.|||Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). http://togogenome.org/gene/985053:VMUT_RS06770 ^@ http://purl.uniprot.org/uniprot/F0QYT1 ^@ Similarity ^@ Belongs to the RuvB family. http://togogenome.org/gene/985053:VMUT_RS08410 ^@ http://purl.uniprot.org/uniprot/F0QU45 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.|||Belongs to the Cren7 family.|||Cytoplasm|||Methylated at multiple sites, to varying extents.|||Monomer. http://togogenome.org/gene/985053:VMUT_RS06270 ^@ http://purl.uniprot.org/uniprot/F0QYI3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/985053:VMUT_RS00435 ^@ http://purl.uniprot.org/uniprot/F0QSF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/985053:VMUT_RS06390 ^@ http://purl.uniprot.org/uniprot/F0QYK7 ^@ Function|||Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.|||Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway. http://togogenome.org/gene/985053:VMUT_RS04805 ^@ http://purl.uniprot.org/uniprot/F0QXA2 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. http://togogenome.org/gene/985053:VMUT_RS10660 ^@ http://purl.uniprot.org/uniprot/F0QWP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NusA family.|||Cytoplasm|||Participates in transcription termination. http://togogenome.org/gene/985053:VMUT_RS04665 ^@ http://purl.uniprot.org/uniprot/F0QWZ5 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/985053:VMUT_RS11380 ^@ http://purl.uniprot.org/uniprot/F0QXI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/985053:VMUT_RS09210 ^@ http://purl.uniprot.org/uniprot/F0QV03 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal DnaG primase family.|||Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. http://togogenome.org/gene/985053:VMUT_RS04520 ^@ http://purl.uniprot.org/uniprot/F0QWW7 ^@ Similarity ^@ Belongs to the SAM hydrolase / SAM-dependent halogenase family. http://togogenome.org/gene/985053:VMUT_RS01125 ^@ http://purl.uniprot.org/uniprot/F0QT10 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/985053:VMUT_RS03150 ^@ http://purl.uniprot.org/uniprot/F0QV86 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/985053:VMUT_RS03995 ^@ http://purl.uniprot.org/uniprot/F0QWD6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS11310 ^@ http://purl.uniprot.org/uniprot/F0QXH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/985053:VMUT_RS10225 ^@ http://purl.uniprot.org/uniprot/F0QW83 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/985053:VMUT_RS06415 ^@ http://purl.uniprot.org/uniprot/F0QYL2 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/985053:VMUT_RS03450 ^@ http://purl.uniprot.org/uniprot/F0QVM4 ^@ Similarity|||Subunit ^@ Belongs to the HTP reductase family.|||Homodimer. http://togogenome.org/gene/985053:VMUT_RS09485 ^@ http://purl.uniprot.org/uniprot/F0QVD8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS08515 ^@ http://purl.uniprot.org/uniprot/F0QUE0 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/985053:VMUT_RS10190 ^@ http://purl.uniprot.org/uniprot/F0QW76 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/985053:VMUT_RS01460 ^@ http://purl.uniprot.org/uniprot/F0QTE7 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/985053:VMUT_RS09290 ^@ http://purl.uniprot.org/uniprot/F0QVA0 ^@ Similarity ^@ Belongs to the UPF0440 family. http://togogenome.org/gene/985053:VMUT_RS02050 ^@ http://purl.uniprot.org/uniprot/F0QU63 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/985053:VMUT_RS10585 ^@ http://purl.uniprot.org/uniprot/F0QWM7 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/985053:VMUT_RS07000 ^@ http://purl.uniprot.org/uniprot/F0QSP4 ^@ Function|||Similarity ^@ Belongs to the MqnA/MqnD family. MqnA subfamily.|||Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). http://togogenome.org/gene/985053:VMUT_RS12115 ^@ http://purl.uniprot.org/uniprot/F0QY47 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HdrA family.|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).|||The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC. http://togogenome.org/gene/985053:VMUT_RS02690 ^@ http://purl.uniprot.org/uniprot/F0QUR6 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs. http://togogenome.org/gene/985053:VMUT_RS07835 ^@ http://purl.uniprot.org/uniprot/F0QTK9 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/985053:VMUT_RS06930 ^@ http://purl.uniprot.org/uniprot/F0QSM9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS04980 ^@ http://purl.uniprot.org/uniprot/F0QXD4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/985053:VMUT_RS10605 ^@ http://purl.uniprot.org/uniprot/F0QWN1 ^@ Similarity ^@ Belongs to the CutA family. http://togogenome.org/gene/985053:VMUT_RS06570 ^@ http://purl.uniprot.org/uniprot/F0QYP1 ^@ Function|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/985053:VMUT_RS01705 ^@ http://purl.uniprot.org/uniprot/F0QTS0 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.|||Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/985053:VMUT_RS06815 ^@ http://purl.uniprot.org/uniprot/F0QSK6 ^@ Similarity ^@ Belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/985053:VMUT_RS01965 ^@ http://purl.uniprot.org/uniprot/F0QTW9 ^@ Similarity ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. http://togogenome.org/gene/985053:VMUT_RS06065 ^@ http://purl.uniprot.org/uniprot/F0QYE2 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/985053:VMUT_RS04110 ^@ http://purl.uniprot.org/uniprot/F0QWF9 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/985053:VMUT_RS06455 ^@ http://purl.uniprot.org/uniprot/F0QYM0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS11580 ^@ http://purl.uniprot.org/uniprot/F0QXM2 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/985053:VMUT_RS06305 ^@ http://purl.uniprot.org/uniprot/F0QYJ0 ^@ Caution|||Function|||Similarity ^@ Belongs to the pseudouridine synthase Pus10 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/985053:VMUT_RS01130 ^@ http://purl.uniprot.org/uniprot/F0QT11 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm|||Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.|||Heterodimer of two subunits, one of which binds GTP. http://togogenome.org/gene/985053:VMUT_RS01380 ^@ http://purl.uniprot.org/uniprot/F0QTD2 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A single active site specifically recognizes both ATP and CTP and is responsible for their addition.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.|||Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.|||Homodimer. http://togogenome.org/gene/985053:VMUT_RS00475 ^@ http://purl.uniprot.org/uniprot/F0QSF7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Located at the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/985053:VMUT_RS06720 ^@ http://purl.uniprot.org/uniprot/F0QYS1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS06100 ^@ http://purl.uniprot.org/uniprot/F0QYE9 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/985053:VMUT_RS08000 ^@ http://purl.uniprot.org/uniprot/F0QTP1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/985053:VMUT_RS07865 ^@ http://purl.uniprot.org/uniprot/F0QTL5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/985053:VMUT_RS01430 ^@ http://purl.uniprot.org/uniprot/F0QTE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.|||Belongs to the TiaS family.|||Cytoplasm http://togogenome.org/gene/985053:VMUT_RS07065 ^@ http://purl.uniprot.org/uniprot/F0QSQ7 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/985053:VMUT_RS01395 ^@ http://purl.uniprot.org/uniprot/F0QTD5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/985053:VMUT_RS00430 ^@ http://purl.uniprot.org/uniprot/F0QSE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/985053:VMUT_RS01425 ^@ http://purl.uniprot.org/uniprot/F0QTE1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.|||Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. http://togogenome.org/gene/985053:VMUT_RS05840 ^@ http://purl.uniprot.org/uniprot/F0QY94 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).|||Belongs to the TDD superfamily. TSR3 family.|||Cytoplasm http://togogenome.org/gene/985053:VMUT_RS03065 ^@ http://purl.uniprot.org/uniprot/F0QV67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTH2 family.|||Cytoplasm|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/985053:VMUT_RS10195 ^@ http://purl.uniprot.org/uniprot/F0QW77 ^@ Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer. http://togogenome.org/gene/985053:VMUT_RS10590 ^@ http://purl.uniprot.org/uniprot/F0QWM8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/985053:VMUT_RS02465 ^@ http://purl.uniprot.org/uniprot/F0QUM2 ^@ Function|||Similarity ^@ Belongs to the NOP10 family.|||Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. http://togogenome.org/gene/985053:VMUT_RS03120 ^@ http://purl.uniprot.org/uniprot/F0QV79 ^@ Similarity ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. http://togogenome.org/gene/985053:VMUT_RS03040 ^@ http://purl.uniprot.org/uniprot/F0QV62 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/985053:VMUT_RS02300 ^@ http://purl.uniprot.org/uniprot/F0QUA9 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/985053:VMUT_RS02680 ^@ http://purl.uniprot.org/uniprot/F0QUR4 ^@ Similarity ^@ Belongs to the Ahb/Nir family. http://togogenome.org/gene/985053:VMUT_RS10810 ^@ http://purl.uniprot.org/uniprot/F0QWS2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homotetramer; dimer of dimers.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/985053:VMUT_RS06665 ^@ http://purl.uniprot.org/uniprot/F0QYR0 ^@ Function|||Similarity ^@ Belongs to the archaeal-type GTP cyclohydrolase family.|||Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity. http://togogenome.org/gene/985053:VMUT_RS07485 ^@ http://purl.uniprot.org/uniprot/F0QT68 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/985053:VMUT_RS03095 ^@ http://purl.uniprot.org/uniprot/F0QV73 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/985053:VMUT_RS02015 ^@ http://purl.uniprot.org/uniprot/F0QU56 ^@ Similarity ^@ Belongs to the ETF alpha-subunit/FixB family. http://togogenome.org/gene/985053:VMUT_RS12120 ^@ http://purl.uniprot.org/uniprot/F0QY48 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HdrA family.|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).|||The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC. http://togogenome.org/gene/985053:VMUT_RS10005 ^@ http://purl.uniprot.org/uniprot/F0QVW2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/985053:VMUT_RS06005 ^@ http://purl.uniprot.org/uniprot/F0QYD1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS11110 ^@ http://purl.uniprot.org/uniprot/F0QX59 ^@ Caution|||Function|||Similarity ^@ Belongs to the Nre family.|||Involved in DNA damage repair.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS03430 ^@ http://purl.uniprot.org/uniprot/F0QVM0 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruD family.|||Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. http://togogenome.org/gene/985053:VMUT_RS07335 ^@ http://purl.uniprot.org/uniprot/F0QT39 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/985053:VMUT_RS06340 ^@ http://purl.uniprot.org/uniprot/F0QYJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/985053:VMUT_RS02095 ^@ http://purl.uniprot.org/uniprot/F0QU71 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/985053:VMUT_RS00595 ^@ http://purl.uniprot.org/uniprot/F0QSI0 ^@ Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/985053:VMUT_RS08125 ^@ http://purl.uniprot.org/uniprot/F0QTZ3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/985053:VMUT_RS04860 ^@ http://purl.uniprot.org/uniprot/F0QXB2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS04125 ^@ http://purl.uniprot.org/uniprot/F0QWG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RAD3/XPD subfamily.|||Nucleus http://togogenome.org/gene/985053:VMUT_RS02270 ^@ http://purl.uniprot.org/uniprot/F0QUA4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.|||Homodimer. http://togogenome.org/gene/985053:VMUT_RS00720 ^@ http://purl.uniprot.org/uniprot/F0QST4 ^@ Similarity ^@ Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. http://togogenome.org/gene/985053:VMUT_RS01750 ^@ http://purl.uniprot.org/uniprot/F0QTS8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS10765 ^@ http://purl.uniprot.org/uniprot/F0QWR3 ^@ Function ^@ Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/985053:VMUT_RS10745 ^@ http://purl.uniprot.org/uniprot/F0QWQ9 ^@ Caution|||Function|||Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS11925 ^@ http://purl.uniprot.org/uniprot/F0QY11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.|||Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.|||Cytoplasm http://togogenome.org/gene/985053:VMUT_RS06980 ^@ http://purl.uniprot.org/uniprot/F0QSP0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/985053:VMUT_RS08810 ^@ http://purl.uniprot.org/uniprot/F0QUJ7 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/985053:VMUT_RS07940 ^@ http://purl.uniprot.org/uniprot/F0QTM9 ^@ Similarity ^@ Belongs to the RimK family. LysX subfamily. http://togogenome.org/gene/985053:VMUT_RS06190 ^@ http://purl.uniprot.org/uniprot/F0QYG7 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/985053:VMUT_RS09345 ^@ http://purl.uniprot.org/uniprot/F0QVB1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcA family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||nucleolus http://togogenome.org/gene/985053:VMUT_RS09125 ^@ http://purl.uniprot.org/uniprot/F0QUY7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29. http://togogenome.org/gene/985053:VMUT_RS03735 ^@ http://purl.uniprot.org/uniprot/F0QW10 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the THI4 family.|||Homooctamer; tetramer of dimers.|||Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS03100 ^@ http://purl.uniprot.org/uniprot/F0QV74 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/985053:VMUT_RS10770 ^@ http://purl.uniprot.org/uniprot/F0QWR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS04215 ^@ http://purl.uniprot.org/uniprot/F0QWH8 ^@ Similarity ^@ Belongs to the complex I 51 kDa subunit family. http://togogenome.org/gene/985053:VMUT_RS08745 ^@ http://purl.uniprot.org/uniprot/F0QUI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/985053:VMUT_RS02200 ^@ http://purl.uniprot.org/uniprot/F0QU92 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. UPF0219 family. http://togogenome.org/gene/985053:VMUT_RS02515 ^@ http://purl.uniprot.org/uniprot/F0QUN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/985053:VMUT_RS03880 ^@ http://purl.uniprot.org/uniprot/F0QW38 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/985053:VMUT_RS10000 ^@ http://purl.uniprot.org/uniprot/F0QVW1 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/985053:VMUT_RS07110 ^@ http://purl.uniprot.org/uniprot/F0QSR6 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/985053:VMUT_RS06300 ^@ http://purl.uniprot.org/uniprot/F0QYI9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/985053:VMUT_RS11020 ^@ http://purl.uniprot.org/uniprot/F0QX41 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/985053:VMUT_RS04630 ^@ http://purl.uniprot.org/uniprot/F0QWY8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/985053:VMUT_RS02450 ^@ http://purl.uniprot.org/uniprot/F0QUL9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/985053:VMUT_RS01470 ^@ http://purl.uniprot.org/uniprot/F0QTE9 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/985053:VMUT_RS02525 ^@ http://purl.uniprot.org/uniprot/F0QUN2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/985053:VMUT_RS03175 ^@ http://purl.uniprot.org/uniprot/F0QVG9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/985053:VMUT_RS04575 ^@ http://purl.uniprot.org/uniprot/F0QWX8 ^@ Similarity ^@ Belongs to the DMRL synthase family. http://togogenome.org/gene/985053:VMUT_RS03930 ^@ http://purl.uniprot.org/uniprot/F0QW47 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/985053:VMUT_RS06585 ^@ http://purl.uniprot.org/uniprot/F0QYP4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/985053:VMUT_RS03340 ^@ http://purl.uniprot.org/uniprot/F0QVK1 ^@ Caution|||Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.|||In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.|||In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.|||Monomer.|||This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures. http://togogenome.org/gene/985053:VMUT_RS06285 ^@ http://purl.uniprot.org/uniprot/F0QYI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Cytoplasm|||Functions by promoting the formation of the first peptide bond. http://togogenome.org/gene/985053:VMUT_RS02895 ^@ http://purl.uniprot.org/uniprot/F0QV34 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/985053:VMUT_RS03360 ^@ http://purl.uniprot.org/uniprot/F0QVK4 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/985053:VMUT_RS09635 ^@ http://purl.uniprot.org/uniprot/F0QVG6 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.|||Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain. http://togogenome.org/gene/985053:VMUT_RS04725 ^@ http://purl.uniprot.org/uniprot/F0QX07 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the TFE family.|||Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.|||The winged helix domain is involved in binding to DNA in the preinitiation complex.|||Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes. http://togogenome.org/gene/985053:VMUT_RS12040 ^@ http://purl.uniprot.org/uniprot/F0QY32 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family. http://togogenome.org/gene/985053:VMUT_RS11550 ^@ http://purl.uniprot.org/uniprot/F0QXL7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/985053:VMUT_RS03115 ^@ http://purl.uniprot.org/uniprot/F0QV78 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/985053:VMUT_RS01405 ^@ http://purl.uniprot.org/uniprot/F0QTD7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.|||Homodimer.|||Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. http://togogenome.org/gene/985053:VMUT_RS02975 ^@ http://purl.uniprot.org/uniprot/F0QV50 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/985053:VMUT_RS02025 ^@ http://purl.uniprot.org/uniprot/F0QU58 ^@ Similarity ^@ Belongs to the protein kinase superfamily. BUD32 family. http://togogenome.org/gene/985053:VMUT_RS00930 ^@ http://purl.uniprot.org/uniprot/F0QST8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.|||Belongs to the Cren7 family.|||Cytoplasm|||Methylated at multiple sites, to varying extents.|||Monomer. http://togogenome.org/gene/985053:VMUT_RS10025 ^@ http://purl.uniprot.org/uniprot/F0QVW6 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/985053:VMUT_RS06840 ^@ http://purl.uniprot.org/uniprot/F0QSL1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.|||Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. http://togogenome.org/gene/985053:VMUT_RS04465 ^@ http://purl.uniprot.org/uniprot/F0QWV6 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/985053:VMUT_RS12050 ^@ http://purl.uniprot.org/uniprot/F0QY34 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/985053:VMUT_RS10010 ^@ http://purl.uniprot.org/uniprot/F0QVW3 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/985053:VMUT_RS02635 ^@ http://purl.uniprot.org/uniprot/F0QUQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DsrC/TusE family.|||Cytoplasm http://togogenome.org/gene/985053:VMUT_RS01685 ^@ http://purl.uniprot.org/uniprot/F0QTR6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6B family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/985053:VMUT_RS09040 ^@ http://purl.uniprot.org/uniprot/F0QUW9 ^@ Similarity ^@ Belongs to the UPF0201 family. http://togogenome.org/gene/985053:VMUT_RS01295 ^@ http://purl.uniprot.org/uniprot/F0QTB8 ^@ Function ^@ Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA. http://togogenome.org/gene/985053:VMUT_RS09230 ^@ http://purl.uniprot.org/uniprot/F0QV07 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS11235 ^@ http://purl.uniprot.org/uniprot/F0QX83 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/985053:VMUT_RS09090 ^@ http://purl.uniprot.org/uniprot/F0QUX9 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Part of the 30S ribosomal subunit. Contacts protein S4.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/985053:VMUT_RS04120 ^@ http://purl.uniprot.org/uniprot/F0QWG1 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/985053:VMUT_RS01935 ^@ http://purl.uniprot.org/uniprot/F0QTW3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.|||Belongs to the Cren7 family.|||Cytoplasm|||Methylated at multiple sites, to varying extents.|||Monomer. http://togogenome.org/gene/985053:VMUT_RS00145 ^@ http://purl.uniprot.org/uniprot/F0QYW3 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/985053:VMUT_RS12045 ^@ http://purl.uniprot.org/uniprot/F0QY33 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/985053:VMUT_RS02035 ^@ http://purl.uniprot.org/uniprot/F0QU60 ^@ Similarity ^@ Belongs to the UPF0179 family. http://togogenome.org/gene/985053:VMUT_RS05720 ^@ http://purl.uniprot.org/uniprot/F0QY70 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS08290 ^@ http://purl.uniprot.org/uniprot/F0QU25 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/985053:VMUT_RS01820 ^@ http://purl.uniprot.org/uniprot/F0QTU2 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/985053:VMUT_RS08350 ^@ http://purl.uniprot.org/uniprot/F0QU36 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/985053:VMUT_RS03155 ^@ http://purl.uniprot.org/uniprot/F0QV87 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/985053:VMUT_RS06055 ^@ http://purl.uniprot.org/uniprot/F0QYE0 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/985053:VMUT_RS03705 ^@ http://purl.uniprot.org/uniprot/F0QW03 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS31 family.|||Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/985053:VMUT_RS04780 ^@ http://purl.uniprot.org/uniprot/F0QX97 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.|||Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/985053:VMUT_RS09285 ^@ http://purl.uniprot.org/uniprot/F0QV99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/985053:VMUT_RS00990 ^@ http://purl.uniprot.org/uniprot/F0QSY4 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/985053:VMUT_RS07315 ^@ http://purl.uniprot.org/uniprot/F0QT35 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/985053:VMUT_RS04425 ^@ http://purl.uniprot.org/uniprot/F0QWU7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/985053:VMUT_RS03055 ^@ http://purl.uniprot.org/uniprot/F0QV65 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/985053:VMUT_RS05515 ^@ http://purl.uniprot.org/uniprot/F0QXV8 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/985053:VMUT_RS03605 ^@ http://purl.uniprot.org/uniprot/F0QVY3 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS07900 ^@ http://purl.uniprot.org/uniprot/F0QTM2 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/985053:VMUT_RS10035 ^@ http://purl.uniprot.org/uniprot/F0QVW8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Homodimer.|||Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS10100 ^@ http://purl.uniprot.org/uniprot/F0QW58 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS06895 ^@ http://purl.uniprot.org/uniprot/F0QSM2 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/985053:VMUT_RS03275 ^@ http://purl.uniprot.org/uniprot/F0QVI9 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. http://togogenome.org/gene/985053:VMUT_RS03000 ^@ http://purl.uniprot.org/uniprot/F0QV55 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/985053:VMUT_RS06025 ^@ http://purl.uniprot.org/uniprot/F0QYD5 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/985053:VMUT_RS06625 ^@ http://purl.uniprot.org/uniprot/F0QYQ2 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/985053:VMUT_RS08265 ^@ http://purl.uniprot.org/uniprot/F0QU20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/985053:VMUT_RS06330 ^@ http://purl.uniprot.org/uniprot/F0QYJ5 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/985053:VMUT_RS12095 ^@ http://purl.uniprot.org/uniprot/F0QY43 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS07345 ^@ http://purl.uniprot.org/uniprot/F0QT41 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/985053:VMUT_RS06695 ^@ http://purl.uniprot.org/uniprot/F0QYR6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS02045 ^@ http://purl.uniprot.org/uniprot/F0QU62 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/985053:VMUT_RS09100 ^@ http://purl.uniprot.org/uniprot/F0QUY1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/985053:VMUT_RS10975 ^@ http://purl.uniprot.org/uniprot/F0QX32 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/985053:VMUT_RS04595 ^@ http://purl.uniprot.org/uniprot/F0QWY2 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/985053:VMUT_RS11510 ^@ http://purl.uniprot.org/uniprot/F0QXL0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS07220 ^@ http://purl.uniprot.org/uniprot/F0QT16 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/985053:VMUT_RS04965 ^@ http://purl.uniprot.org/uniprot/F0QXD1 ^@ Function|||Similarity ^@ Belongs to the AdoMet synthase 2 family.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/985053:VMUT_RS04135 ^@ http://purl.uniprot.org/uniprot/F0QWG4 ^@ Similarity ^@ Belongs to the type IA topoisomerase family. http://togogenome.org/gene/985053:VMUT_RS01120 ^@ http://purl.uniprot.org/uniprot/F0QT09 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/985053:VMUT_RS00795 ^@ http://purl.uniprot.org/uniprot/F0QSU6 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/985053:VMUT_RS00480 ^@ http://purl.uniprot.org/uniprot/F0QSF8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/985053:VMUT_RS07775 ^@ http://purl.uniprot.org/uniprot/F0QTJ9 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/985053:VMUT_RS02100 ^@ http://purl.uniprot.org/uniprot/F0QU72 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/985053:VMUT_RS10230 ^@ http://purl.uniprot.org/uniprot/F0QW84 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/985053:VMUT_RS01815 ^@ http://purl.uniprot.org/uniprot/F0QTU1 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/985053:VMUT_RS03920 ^@ http://purl.uniprot.org/uniprot/F0QW45 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/985053:VMUT_RS00310 ^@ http://purl.uniprot.org/uniprot/F0QYZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endonuclease V family.|||Cytoplasm|||DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. http://togogenome.org/gene/985053:VMUT_RS10580 ^@ http://purl.uniprot.org/uniprot/F0QWM6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/985053:VMUT_RS09115 ^@ http://purl.uniprot.org/uniprot/F0QUY5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e. http://togogenome.org/gene/985053:VMUT_RS11230 ^@ http://purl.uniprot.org/uniprot/F0QX82 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TYW1 family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).|||Cytoplasm|||Monomer. http://togogenome.org/gene/985053:VMUT_RS07790 ^@ http://purl.uniprot.org/uniprot/F0QTK2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS03405 ^@ http://purl.uniprot.org/uniprot/F0QVL5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS08270 ^@ http://purl.uniprot.org/uniprot/F0QU21 ^@ Similarity ^@ Belongs to the carbamate kinase family. http://togogenome.org/gene/985053:VMUT_RS01515 ^@ http://purl.uniprot.org/uniprot/F0QTF7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NucS endonuclease family.|||Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.|||Cytoplasm http://togogenome.org/gene/985053:VMUT_RS08690 ^@ http://purl.uniprot.org/uniprot/F0QUH4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp42 subfamily.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. http://togogenome.org/gene/985053:VMUT_RS01560 ^@ http://purl.uniprot.org/uniprot/F0QTP3 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/985053:VMUT_RS08100 ^@ http://purl.uniprot.org/uniprot/F0QTY8 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/985053:VMUT_RS06240 ^@ http://purl.uniprot.org/uniprot/F0QYH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm http://togogenome.org/gene/985053:VMUT_RS04085 ^@ http://purl.uniprot.org/uniprot/F0QWF3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the urocanase family.|||Binds 1 NAD(+) per subunit.|||Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS04990 ^@ http://purl.uniprot.org/uniprot/F0QXD6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/985053:VMUT_RS06515 ^@ http://purl.uniprot.org/uniprot/F0QYN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/985053:VMUT_RS05855 ^@ http://purl.uniprot.org/uniprot/F0QY97 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/985053:VMUT_RS04700 ^@ http://purl.uniprot.org/uniprot/F0QX02 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/985053:VMUT_RS10940 ^@ http://purl.uniprot.org/uniprot/F0QX25 ^@ Function ^@ Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA. http://togogenome.org/gene/985053:VMUT_RS04840 ^@ http://purl.uniprot.org/uniprot/F0QXA8 ^@ Function|||Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family.|||Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. http://togogenome.org/gene/985053:VMUT_RS01840 ^@ http://purl.uniprot.org/uniprot/F0QTU6 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/985053:VMUT_RS09105 ^@ http://purl.uniprot.org/uniprot/F0QUY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/985053:VMUT_RS04280 ^@ http://purl.uniprot.org/uniprot/F0QWJ1 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/985053:VMUT_RS10655 ^@ http://purl.uniprot.org/uniprot/F0QWP1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/985053:VMUT_RS08150 ^@ http://purl.uniprot.org/uniprot/F0QTZ8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/985053:VMUT_RS09140 ^@ http://purl.uniprot.org/uniprot/F0QUZ0 ^@ Similarity ^@ Belongs to the HAM1 NTPase family. http://togogenome.org/gene/985053:VMUT_RS02330 ^@ http://purl.uniprot.org/uniprot/F0QUB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm http://togogenome.org/gene/985053:VMUT_RS08570 ^@ http://purl.uniprot.org/uniprot/F0QUF1 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/985053:VMUT_RS05055 ^@ http://purl.uniprot.org/uniprot/F0QXE9 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/985053:VMUT_RS12015 ^@ http://purl.uniprot.org/uniprot/F0QY27 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/985053:VMUT_RS06810 ^@ http://purl.uniprot.org/uniprot/F0QSK5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.|||Cell membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. http://togogenome.org/gene/985053:VMUT_RS03520 ^@ http://purl.uniprot.org/uniprot/F0QVN8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/985053:VMUT_RS04955 ^@ http://purl.uniprot.org/uniprot/F0QXC9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/985053:VMUT_RS09845 ^@ http://purl.uniprot.org/uniprot/F0QVT3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS08435 ^@ http://purl.uniprot.org/uniprot/F0QUC7 ^@ Cofactor|||Function|||Subunit ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer composed of an alpha and a beta subunit.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/985053:VMUT_RS02440 ^@ http://purl.uniprot.org/uniprot/F0QUL7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase small subunit family.|||Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/985053:VMUT_RS05795 ^@ http://purl.uniprot.org/uniprot/F0QY85 ^@ Function|||Similarity ^@ Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.|||Belongs to the archease family. http://togogenome.org/gene/985053:VMUT_RS06685 ^@ http://purl.uniprot.org/uniprot/F0QYR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS01025 ^@ http://purl.uniprot.org/uniprot/F0QSZ0 ^@ Caution|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS01350 ^@ http://purl.uniprot.org/uniprot/F0QTC6 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. http://togogenome.org/gene/985053:VMUT_RS09180 ^@ http://purl.uniprot.org/uniprot/F0QUZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/985053:VMUT_RS02435 ^@ http://purl.uniprot.org/uniprot/F0QUL6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.|||Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. http://togogenome.org/gene/985053:VMUT_RS10960 ^@ http://purl.uniprot.org/uniprot/F0QX29 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. http://togogenome.org/gene/985053:VMUT_RS00685 ^@ http://purl.uniprot.org/uniprot/F0QSJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.|||Membrane http://togogenome.org/gene/985053:VMUT_RS06295 ^@ http://purl.uniprot.org/uniprot/F0QYI8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.|||Nucleus|||Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure. http://togogenome.org/gene/985053:VMUT_RS03570 ^@ http://purl.uniprot.org/uniprot/F0QVX6 ^@ Similarity ^@ Belongs to the Nth/MutY family. http://togogenome.org/gene/985053:VMUT_RS06280 ^@ http://purl.uniprot.org/uniprot/F0QYI5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS03715 ^@ http://purl.uniprot.org/uniprot/F0QW06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/985053:VMUT_RS00755 ^@ http://purl.uniprot.org/uniprot/F0QST8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.|||Belongs to the Cren7 family.|||Cytoplasm|||Methylated at multiple sites, to varying extents.|||Monomer. http://togogenome.org/gene/985053:VMUT_RS02865 ^@ http://purl.uniprot.org/uniprot/F0QV28 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/985053:VMUT_RS08330 ^@ http://purl.uniprot.org/uniprot/F0QU32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/985053:VMUT_RS02460 ^@ http://purl.uniprot.org/uniprot/F0QUM1 ^@ Similarity ^@ Belongs to the eIF-2-alpha family. http://togogenome.org/gene/985053:VMUT_RS08245 ^@ http://purl.uniprot.org/uniprot/F0QU16 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/985053:VMUT_RS06235 ^@ http://purl.uniprot.org/uniprot/F0QYH6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS00640 ^@ http://purl.uniprot.org/uniprot/F0QSI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic CoaD family.|||Cytoplasm|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/985053:VMUT_RS02760 ^@ http://purl.uniprot.org/uniprot/F0QV08 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/985053:VMUT_RS01115 ^@ http://purl.uniprot.org/uniprot/F0QT08 ^@ Similarity ^@ Belongs to the isopentenyl phosphate kinase family. http://togogenome.org/gene/985053:VMUT_RS09135 ^@ http://purl.uniprot.org/uniprot/F0QUY9 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/985053:VMUT_RS10245 ^@ http://purl.uniprot.org/uniprot/F0QW87 ^@ Similarity ^@ Belongs to the PNP/UDP phosphorylase family. http://togogenome.org/gene/985053:VMUT_RS04500 ^@ http://purl.uniprot.org/uniprot/F0QWW3 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/985053:VMUT_RS08980 ^@ http://purl.uniprot.org/uniprot/F0QUV6 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family.|||Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. http://togogenome.org/gene/985053:VMUT_RS04940 ^@ http://purl.uniprot.org/uniprot/F0QXC6 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/985053:VMUT_RS09250 ^@ http://purl.uniprot.org/uniprot/F0QV91 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/985053:VMUT_RS07355 ^@ http://purl.uniprot.org/uniprot/F0QT43 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS03810 ^@ http://purl.uniprot.org/uniprot/F0QW24 ^@ Similarity ^@ Belongs to the PGI/PMI family. http://togogenome.org/gene/985053:VMUT_RS01555 ^@ http://purl.uniprot.org/uniprot/F0QTG6 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family.|||Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). http://togogenome.org/gene/985053:VMUT_RS09610 ^@ http://purl.uniprot.org/uniprot/F0QVG1 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/985053:VMUT_RS03765 ^@ http://purl.uniprot.org/uniprot/F0QW15 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/985053:VMUT_RS10880 ^@ http://purl.uniprot.org/uniprot/F0QWT5 ^@ Similarity ^@ Belongs to the complex I 49 kDa subunit family. http://togogenome.org/gene/985053:VMUT_RS00205 ^@ http://purl.uniprot.org/uniprot/F0QYX5 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/985053:VMUT_RS11150 ^@ http://purl.uniprot.org/uniprot/F0QX67 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/985053:VMUT_RS06620 ^@ http://purl.uniprot.org/uniprot/F0QYQ1 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/985053:VMUT_RS04795 ^@ http://purl.uniprot.org/uniprot/F0QXA0 ^@ Similarity ^@ Belongs to the BlaI transcriptional regulatory family. http://togogenome.org/gene/985053:VMUT_RS07965 ^@ http://purl.uniprot.org/uniprot/F0QTN4 ^@ Subunit ^@ Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/985053:VMUT_RS00255 ^@ http://purl.uniprot.org/uniprot/F0QYY4 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum lumen http://togogenome.org/gene/985053:VMUT_RS00800 ^@ http://purl.uniprot.org/uniprot/F0QSU7 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/985053:VMUT_RS07675 ^@ http://purl.uniprot.org/uniprot/F0QTI2 ^@ Similarity ^@ Belongs to the CRISPR-associated Csm3 family. http://togogenome.org/gene/985053:VMUT_RS01940 ^@ http://purl.uniprot.org/uniprot/F0QTW4 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family. http://togogenome.org/gene/985053:VMUT_RS00690 ^@ http://purl.uniprot.org/uniprot/F0QSJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CitM (TC 2.A.11) transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/985053:VMUT_RS09995 ^@ http://purl.uniprot.org/uniprot/F0QVW0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Homodimer. http://togogenome.org/gene/985053:VMUT_RS04010 ^@ http://purl.uniprot.org/uniprot/F0QWD9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm http://togogenome.org/gene/985053:VMUT_RS08965 ^@ http://purl.uniprot.org/uniprot/F0QUV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/985053:VMUT_RS08695 ^@ http://purl.uniprot.org/uniprot/F0QUH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp41 subfamily.|||Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm http://togogenome.org/gene/985053:VMUT_RS11100 ^@ http://purl.uniprot.org/uniprot/F0QX57 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS09970 ^@ http://purl.uniprot.org/uniprot/F0QVV5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal phosphopantothenate synthetase family.|||Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.|||Homodimer. http://togogenome.org/gene/985053:VMUT_RS09805 ^@ http://purl.uniprot.org/uniprot/F0QVS6 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/985053:VMUT_RS09380 ^@ http://purl.uniprot.org/uniprot/F0QVB8 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/985053:VMUT_RS02195 ^@ http://purl.uniprot.org/uniprot/F0QU91 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/985053:VMUT_RS09035 ^@ http://purl.uniprot.org/uniprot/F0QUW8 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/985053:VMUT_RS08675 ^@ http://purl.uniprot.org/uniprot/F0QUH1 ^@ Function|||Similarity ^@ Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/985053:VMUT_RS08075 ^@ http://purl.uniprot.org/uniprot/F0QTY3 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/985053:VMUT_RS04030 ^@ http://purl.uniprot.org/uniprot/F0QWE3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose 5-phosphate isomerase family.|||Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.|||Homodimer. http://togogenome.org/gene/985053:VMUT_RS08960 ^@ http://purl.uniprot.org/uniprot/F0QUV2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/985053:VMUT_RS02520 ^@ http://purl.uniprot.org/uniprot/F0QUN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/985053:VMUT_RS04235 ^@ http://purl.uniprot.org/uniprot/F0QWI2 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the asparaginase 1 family. GatD subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/985053:VMUT_RS01600 ^@ http://purl.uniprot.org/uniprot/F0QTQ1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/985053:VMUT_RS04890 ^@ http://purl.uniprot.org/uniprot/F0QXB7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS07320 ^@ http://purl.uniprot.org/uniprot/F0QT36 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS02285 ^@ http://purl.uniprot.org/uniprot/F0QUA7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the diphthine synthase family.|||Homodimer.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/985053:VMUT_RS03535 ^@ http://purl.uniprot.org/uniprot/F0QVP1 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. http://togogenome.org/gene/985053:VMUT_RS04845 ^@ http://purl.uniprot.org/uniprot/F0QXA9 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/985053:VMUT_RS07950 ^@ http://purl.uniprot.org/uniprot/F0QTN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. LysZ subfamily.|||Cytoplasm|||Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis). http://togogenome.org/gene/985053:VMUT_RS03495 ^@ http://purl.uniprot.org/uniprot/F0QVN3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS04295 ^@ http://purl.uniprot.org/uniprot/F0QWJ4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. http://togogenome.org/gene/985053:VMUT_RS09640 ^@ http://purl.uniprot.org/uniprot/F0QVP5 ^@ Similarity ^@ Belongs to the SIS family. PHI subfamily. http://togogenome.org/gene/985053:VMUT_RS04240 ^@ http://purl.uniprot.org/uniprot/F0QWI3 ^@ Similarity ^@ Belongs to the SfsA family. http://togogenome.org/gene/985053:VMUT_RS03160 ^@ http://purl.uniprot.org/uniprot/F0QVG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/985053:VMUT_RS01775 ^@ http://purl.uniprot.org/uniprot/F0QTT3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/985053:VMUT_RS02420 ^@ http://purl.uniprot.org/uniprot/F0QUL3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||May be involved in maturation of the 30S ribosomal subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/985053:VMUT_RS10710 ^@ http://purl.uniprot.org/uniprot/F0QWQ2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.|||Monomer.|||The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity. http://togogenome.org/gene/985053:VMUT_RS09375 ^@ http://purl.uniprot.org/uniprot/F0QVB7 ^@ Similarity ^@ Belongs to the serine/threonine dehydratase family. http://togogenome.org/gene/985053:VMUT_RS04750 ^@ http://purl.uniprot.org/uniprot/F0QX12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/985053:VMUT_RS06425 ^@ http://purl.uniprot.org/uniprot/F0QYL4 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/985053:VMUT_RS07275 ^@ http://purl.uniprot.org/uniprot/F0QT27 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/985053:VMUT_RS08340 ^@ http://purl.uniprot.org/uniprot/F0QU34 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GGGP/HepGP synthase family. Group II subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/985053:VMUT_RS10395 ^@ http://purl.uniprot.org/uniprot/F0QWB3 ^@ Similarity ^@ Belongs to the HepT RNase toxin family. http://togogenome.org/gene/985053:VMUT_RS03970 ^@ http://purl.uniprot.org/uniprot/F0QWD1 ^@ Similarity ^@ Belongs to the UPF0282 family. http://togogenome.org/gene/985053:VMUT_RS08530 ^@ http://purl.uniprot.org/uniprot/F0QUE3 ^@ Function|||Similarity ^@ Belongs to the archaeal SPP-like hydrolase family.|||Catalyzes the dephosphorylation of 2-phosphoglycolate. http://togogenome.org/gene/985053:VMUT_RS00295 ^@ http://purl.uniprot.org/uniprot/F0QYZ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS07075 ^@ http://purl.uniprot.org/uniprot/F0QSQ9 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/985053:VMUT_RS08645 ^@ http://purl.uniprot.org/uniprot/F0QUG5 ^@ Function|||Similarity ^@ Belongs to the TBP family.|||General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. http://togogenome.org/gene/985053:VMUT_RS05265 ^@ http://purl.uniprot.org/uniprot/F0QXQ9 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family.|||Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. http://togogenome.org/gene/985053:VMUT_RS09220 ^@ http://purl.uniprot.org/uniprot/F0QV05 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS09515 ^@ http://purl.uniprot.org/uniprot/F0QVE3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobD/CbiB family.|||Cell membrane|||Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/985053:VMUT_RS09190 ^@ http://purl.uniprot.org/uniprot/F0QUZ9 ^@ Similarity ^@ Belongs to the malic enzymes family. http://togogenome.org/gene/985053:VMUT_RS06545 ^@ http://purl.uniprot.org/uniprot/F0QYN6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/985053:VMUT_RS06385 ^@ http://purl.uniprot.org/uniprot/F0QYK6 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/985053:VMUT_RS03320 ^@ http://purl.uniprot.org/uniprot/F0QVJ7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/985053:VMUT_RS07420 ^@ http://purl.uniprot.org/uniprot/F0QT55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS03580 ^@ http://purl.uniprot.org/uniprot/F0QVX8 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/985053:VMUT_RS01545 ^@ http://purl.uniprot.org/uniprot/F0QTG4 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.|||Specifically catalyzes the decarboxylation of L-arginine to agmatine. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity. http://togogenome.org/gene/985053:VMUT_RS09465 ^@ http://purl.uniprot.org/uniprot/F0QVD5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS03400 ^@ http://purl.uniprot.org/uniprot/F0QVL3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 large subunit family.|||Belongs to the activator 1 small subunits family. RfcL subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/985053:VMUT_RS08680 ^@ http://purl.uniprot.org/uniprot/F0QUH2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M32 family.|||Binds 1 zinc ion per subunit.|||Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. http://togogenome.org/gene/985053:VMUT_RS09585 ^@ http://purl.uniprot.org/uniprot/F0QVF6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 57 family. http://togogenome.org/gene/985053:VMUT_RS02335 ^@ http://purl.uniprot.org/uniprot/F0QUB7 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/985053:VMUT_RS00775 ^@ http://purl.uniprot.org/uniprot/F0QSU2 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/985053:VMUT_RS06960 ^@ http://purl.uniprot.org/uniprot/F0QSN6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/985053:VMUT_RS04970 ^@ http://purl.uniprot.org/uniprot/F0QXD2 ^@ Similarity ^@ Belongs to the snRNP Sm proteins family. http://togogenome.org/gene/985053:VMUT_RS11450 ^@ http://purl.uniprot.org/uniprot/F0QXJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/985053:VMUT_RS09120 ^@ http://purl.uniprot.org/uniprot/F0QUY6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/985053:VMUT_RS05890 ^@ http://purl.uniprot.org/uniprot/F0QYA4 ^@ Similarity ^@ Belongs to the ETF alpha-subunit/FixB family. http://togogenome.org/gene/985053:VMUT_RS08760 ^@ http://purl.uniprot.org/uniprot/F0QUI7 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/985053:VMUT_RS02415 ^@ http://purl.uniprot.org/uniprot/F0QUL2 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/985053:VMUT_RS12445 ^@ http://purl.uniprot.org/uniprot/F0QW32 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL40 family. http://togogenome.org/gene/985053:VMUT_RS07280 ^@ http://purl.uniprot.org/uniprot/F0QT28 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/985053:VMUT_RS00170 ^@ http://purl.uniprot.org/uniprot/F0QYW8 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/985053:VMUT_RS08640 ^@ http://purl.uniprot.org/uniprot/F0QUG4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/985053:VMUT_RS04055 ^@ http://purl.uniprot.org/uniprot/F0QWE8 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/985053:VMUT_RS06210 ^@ http://purl.uniprot.org/uniprot/F0QYH1 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/985053:VMUT_RS11940 ^@ http://purl.uniprot.org/uniprot/F0QY14 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/985053:VMUT_RS10175 ^@ http://purl.uniprot.org/uniprot/F0QW73 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS01810 ^@ http://purl.uniprot.org/uniprot/F0QTU0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges. http://togogenome.org/gene/985053:VMUT_RS07860 ^@ http://purl.uniprot.org/uniprot/F0QTL4 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS00055 ^@ http://purl.uniprot.org/uniprot/F0QYU7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS02145 ^@ http://purl.uniprot.org/uniprot/F0QU82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/985053:VMUT_RS02030 ^@ http://purl.uniprot.org/uniprot/F0QU59 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/985053:VMUT_RS10600 ^@ http://purl.uniprot.org/uniprot/F0QWN0 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/985053:VMUT_RS07330 ^@ http://purl.uniprot.org/uniprot/F0QT38 ^@ Function ^@ The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/985053:VMUT_RS07080 ^@ http://purl.uniprot.org/uniprot/F0QSR0 ^@ Similarity|||Subunit ^@ Belongs to the TPP enzyme family.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/985053:VMUT_RS02795 ^@ http://purl.uniprot.org/uniprot/F0QV15 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS00115 ^@ http://purl.uniprot.org/uniprot/F0QYV7 ^@ Similarity ^@ Belongs to the peptidase S45 family. http://togogenome.org/gene/985053:VMUT_RS01030 ^@ http://purl.uniprot.org/uniprot/F0QSZ1 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/985053:VMUT_RS11025 ^@ http://purl.uniprot.org/uniprot/F0QX42 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS03240 ^@ http://purl.uniprot.org/uniprot/F0QVI2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS06250 ^@ http://purl.uniprot.org/uniprot/F0QYH9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. Hel308 subfamily.|||DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.|||Monomer. http://togogenome.org/gene/985053:VMUT_RS04170 ^@ http://purl.uniprot.org/uniprot/F0QWH1 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS00460 ^@ http://purl.uniprot.org/uniprot/F0QSF4 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/985053:VMUT_RS11285 ^@ http://purl.uniprot.org/uniprot/F0QX93 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/985053:VMUT_RS02255 ^@ http://purl.uniprot.org/uniprot/F0QUA2 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/985053:VMUT_RS06835 ^@ http://purl.uniprot.org/uniprot/F0QSL0 ^@ Similarity ^@ Belongs to the NOP5/NOP56 family. http://togogenome.org/gene/985053:VMUT_RS06565 ^@ http://purl.uniprot.org/uniprot/F0QYP0 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. http://togogenome.org/gene/985053:VMUT_RS11755 ^@ http://purl.uniprot.org/uniprot/F0QXY4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS04760 ^@ http://purl.uniprot.org/uniprot/F0QX14 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/985053:VMUT_RS02675 ^@ http://purl.uniprot.org/uniprot/F0QUR3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/985053:VMUT_RS01160 ^@ http://purl.uniprot.org/uniprot/F0QT96 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.