http://togogenome.org/gene/9940:HCRTR1 ^@ http://purl.uniprot.org/uniprot/W5NTE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:VXN ^@ http://purl.uniprot.org/uniprot/A0A836ACE5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101104808 ^@ http://purl.uniprot.org/uniprot/W5Q416 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9940:TPST2 ^@ http://purl.uniprot.org/uniprot/A0A6P3T242|||http://purl.uniprot.org/uniprot/W5NTR0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein sulfotransferase family.|||Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.|||Golgi apparatus membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RBCK1 ^@ http://purl.uniprot.org/uniprot/W5QCS0 ^@ Similarity ^@ Belongs to the RBR family. http://togogenome.org/gene/9940:BSCL2 ^@ http://purl.uniprot.org/uniprot/A0A835ZTH6 ^@ Caution|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARMCX3 ^@ http://purl.uniprot.org/uniprot/A0A835ZKA9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eutherian X-chromosome-specific Armcx family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ESRRG ^@ http://purl.uniprot.org/uniprot/W5PNX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9940:ING2 ^@ http://purl.uniprot.org/uniprot/W5PB66 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9940:BEX5 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENF1 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9940:SPTLC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E0Y3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CARMIL1 ^@ http://purl.uniprot.org/uniprot/W5P1B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CARMIL family.|||Cytoplasm http://togogenome.org/gene/9940:ASB17 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6K4|||http://purl.uniprot.org/uniprot/W5PTC6 ^@ Caution|||Function ^@ May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101113259 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBZ8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101114793 ^@ http://purl.uniprot.org/uniprot/A0A6P3TRH2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101118455 ^@ http://purl.uniprot.org/uniprot/W5P4B0 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9940:CFAP20 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJG7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ERAP1 ^@ http://purl.uniprot.org/uniprot/W5Q8S5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Membrane http://togogenome.org/gene/9940:TBRG1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EK09|||http://purl.uniprot.org/uniprot/W5PKT8 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC106990881 ^@ http://purl.uniprot.org/uniprot/A0A835ZJ51|||http://purl.uniprot.org/uniprot/K4P217 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL22 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BACE2 ^@ http://purl.uniprot.org/uniprot/W5PK88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Membrane http://togogenome.org/gene/9940:NDUFAF4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFV5 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the NDUFAF4 family.|||Binds calmodulin. Interacts with NDUFAF3.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCDC77 ^@ http://purl.uniprot.org/uniprot/A0A6P3TQR7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM183A ^@ http://purl.uniprot.org/uniprot/W5NR90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM183 family.|||Membrane http://togogenome.org/gene/9940:AP4S1 ^@ http://purl.uniprot.org/uniprot/W5P7C9 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/9940:FIGN ^@ http://purl.uniprot.org/uniprot/W5P7F0 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9940:TMEM38A ^@ http://purl.uniprot.org/uniprot/A0A6P3EDH3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HMGCR ^@ http://purl.uniprot.org/uniprot/A0A6P7E814 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMG-CoA reductase family.|||Endoplasmic reticulum membrane|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9940:KATNBL1 ^@ http://purl.uniprot.org/uniprot/A0A6P7DW96 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MGST2 ^@ http://purl.uniprot.org/uniprot/W5PTY0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9940:KCNK7 ^@ http://purl.uniprot.org/uniprot/W5Q3N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9940:URM1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9J3|||http://purl.uniprot.org/uniprot/W5PKI4 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.|||Belongs to the URM1 family.|||C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.|||Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BPGM ^@ http://purl.uniprot.org/uniprot/A0A6P3TG89 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9940:WASF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8H0|||http://purl.uniprot.org/uniprot/W5PKA3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytoskeleton http://togogenome.org/gene/9940:NFIA ^@ http://purl.uniprot.org/uniprot/A0A6P3DYV1|||http://purl.uniprot.org/uniprot/W5PGE5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TREX2 ^@ http://purl.uniprot.org/uniprot/A0A836CSF5 ^@ Caution|||Similarity ^@ Belongs to the exonuclease superfamily. TREX family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101122717 ^@ http://purl.uniprot.org/uniprot/W5P456 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9940:FKBP6 ^@ http://purl.uniprot.org/uniprot/W5PTI8 ^@ Function|||Similarity ^@ Belongs to the FKBP6 family.|||Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes. http://togogenome.org/gene/9940:GET1 ^@ http://purl.uniprot.org/uniprot/A0A836AQC2|||http://purl.uniprot.org/uniprot/W5PIY4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WRB/GET1 family.|||Endoplasmic reticulum membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MLLT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YLP9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AZIN1 ^@ http://purl.uniprot.org/uniprot/A0A836CZ70 ^@ Caution|||Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLA2G4A ^@ http://purl.uniprot.org/uniprot/A0A6P3EJX2|||http://purl.uniprot.org/uniprot/W5PDL0 ^@ Caution|||Domain ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCDC91 ^@ http://purl.uniprot.org/uniprot/A0A6P3YIS7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GALNT3 ^@ http://purl.uniprot.org/uniprot/W5P510 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9940:SLAMF7 ^@ http://purl.uniprot.org/uniprot/A0A6P3TK83 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GLRX ^@ http://purl.uniprot.org/uniprot/B2ZA84 ^@ Function ^@ Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. http://togogenome.org/gene/9940:LOC101102551 ^@ http://purl.uniprot.org/uniprot/W5Q872 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:PJVK ^@ http://purl.uniprot.org/uniprot/W5Q787 ^@ Similarity ^@ Belongs to the gasdermin family. http://togogenome.org/gene/9940:BPI ^@ http://purl.uniprot.org/uniprot/T2FG11 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Cytoplasmic granule membrane|||Membrane|||Monomer. Homodimer; disulfide-linked.|||Secreted|||The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.|||The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.|||The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. http://togogenome.org/gene/9940:GPAT4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EER8|||http://purl.uniprot.org/uniprot/W5NWR4 ^@ Caution|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC39A2 ^@ http://purl.uniprot.org/uniprot/C7BDW0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:LOC101103482 ^@ http://purl.uniprot.org/uniprot/W5NWQ6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9940:ENDOG ^@ http://purl.uniprot.org/uniprot/W5PHY0 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/9940:VPS50 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4G8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLDN12 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3V1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Membrane|||tight junction http://togogenome.org/gene/9940:CC2D1B ^@ http://purl.uniprot.org/uniprot/A0A6P3TJQ6 ^@ Similarity ^@ Belongs to the CC2D1 family. http://togogenome.org/gene/9940:CCR3 ^@ http://purl.uniprot.org/uniprot/Q9N0M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:WDR45 ^@ http://purl.uniprot.org/uniprot/A0A6P3ESE9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PROPPIN family.|||Preautophagosomal structure|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101104205 ^@ http://purl.uniprot.org/uniprot/W5P812 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Endoplasmic reticulum|||In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.|||Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.|||Membrane|||Mitochondrion inner membrane|||Monomer. Also occurs as a complex with tryptase in mast cells.|||Nucleus membrane|||cytosol|||extracellular matrix http://togogenome.org/gene/9940:SPARC ^@ http://purl.uniprot.org/uniprot/A0A6P3CXP3|||http://purl.uniprot.org/uniprot/A0A6P3TLP4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|||Belongs to the SPARC family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||basement membrane http://togogenome.org/gene/9940:RLBP1 ^@ http://purl.uniprot.org/uniprot/A0A835ZQI3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MYOD1 ^@ http://purl.uniprot.org/uniprot/A0A836CVY1|||http://purl.uniprot.org/uniprot/P29331 ^@ Caution|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function (By similarity).|||Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).|||Efficient DNA binding requires dimerization with another bHLH protein.|||Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1. Interacts with DDX5. Interacts with CHD2. Interacts with TSC22D3 (By similarity). Interacts with SETD3 (By similarity). Interacts with P-TEFB complex; promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation (By similarity). Interacts with CSRP3 (By similarity). Interacts with NUPR1 (By similarity).|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Methylation at Lys-104 by EHMT2/G9a inhibits myogenic activity.|||Nucleus|||Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation (By similarity).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Ubiquitinated on the N-terminus; which is required for proteasomal degradation. http://togogenome.org/gene/9940:VEGFA ^@ http://purl.uniprot.org/uniprot/P50412 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PDGF/VEGF growth factor family.|||Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).|||Homodimer; disulfide-linked (By similarity). Also found as heterodimer with PGF (By similarity). Interacts with NRP1 (By similarity). Interacts with BSG (By similarity). http://togogenome.org/gene/9940:CIDEC ^@ http://purl.uniprot.org/uniprot/A0A835ZW13 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:JAKMIP2 ^@ http://purl.uniprot.org/uniprot/W5P0N2 ^@ Similarity ^@ Belongs to the JAKMIP family. http://togogenome.org/gene/9940:NFYB ^@ http://purl.uniprot.org/uniprot/A0A6P3TLW9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NFYB/HAP3 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.|||Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP. http://togogenome.org/gene/9940:PURA ^@ http://purl.uniprot.org/uniprot/Q9MYX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PUR DNA-binding protein family.|||Nucleus http://togogenome.org/gene/9940:EFS ^@ http://purl.uniprot.org/uniprot/W5QDG5 ^@ Similarity ^@ Belongs to the CAS family. http://togogenome.org/gene/9940:LOC101109892 ^@ http://purl.uniprot.org/uniprot/A0A6P7EIW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYBC1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9940:VDAC1 ^@ http://purl.uniprot.org/uniprot/A0A6P7EFR0|||http://purl.uniprot.org/uniprot/B2LYK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic mitochondrial porin family.|||Cell membrane|||Membrane|||Membrane raft http://togogenome.org/gene/9940:LGMN ^@ http://purl.uniprot.org/uniprot/W5PUH5 ^@ Similarity ^@ Belongs to the peptidase C13 family. http://togogenome.org/gene/9940:SFR1 ^@ http://purl.uniprot.org/uniprot/W5P8V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SFR1/MEI5 family.|||Nucleus http://togogenome.org/gene/9940:GDF10 ^@ http://purl.uniprot.org/uniprot/W5NSY5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer.|||Secreted http://togogenome.org/gene/9940:CDC42BPA ^@ http://purl.uniprot.org/uniprot/W5NW15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.|||Cytoplasm|||lamellipodium http://togogenome.org/gene/9940:DPM3 ^@ http://purl.uniprot.org/uniprot/A0A836AGQ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM3 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C1H1orf141 ^@ http://purl.uniprot.org/uniprot/A0A6P3TAP8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:COPA ^@ http://purl.uniprot.org/uniprot/A0A6P3E7F4|||http://purl.uniprot.org/uniprot/W5PFV7 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MBOAT4 ^@ http://purl.uniprot.org/uniprot/K9MH73 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:RELN ^@ http://purl.uniprot.org/uniprot/A0A067YHI4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the reelin family.|||Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Oligomer of disulfide-linked homodimers. Binds to the ectodomains of VLDLR and LRP8/APOER2.|||extracellular matrix http://togogenome.org/gene/9940:LOC100135455 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQR6 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/9940:APOBEC3A ^@ http://purl.uniprot.org/uniprot/B7T159 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Nucleus|||P-body http://togogenome.org/gene/9940:LOC101117542 ^@ http://purl.uniprot.org/uniprot/A0A835ZYG0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OLFM4 ^@ http://purl.uniprot.org/uniprot/W5P9S6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:ELAVL3 ^@ http://purl.uniprot.org/uniprot/W5QAS8 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/9940:TTC39C ^@ http://purl.uniprot.org/uniprot/W5PCF6 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/9940:LOC101110265 ^@ http://purl.uniprot.org/uniprot/A0A836CY35 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PTGS2 ^@ http://purl.uniprot.org/uniprot/P79208 ^@ Cofactor|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated at Ser-564 by SPHK1. During neuroinflammation, acetylation by SPHK1 promotes neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, which results in an increase of phagocytic microglia.|||Belongs to the prostaglandin G/H synthase family.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|||Conversion of arachidonate to prostaglandin H2 is mediated by 2 different isozymes: the constitutive PTGS1 and the inducible PTGS2. PTGS1 is expressed constitutively and generally produces prostanoids acutely in response to hormonal stimuli to fine-tune physiological processes requiring instantaneous, continuous regulation (e.g. hemostasis). PTGS2 is inducible and typically produces prostanoids that mediate responses to physiological stresses such as infection and inflammation.|||Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response (PubMed:10438452). The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes (PubMed:10438452). This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons (By similarity). Similarly catalyzes successive cyclooxygenation and peroxidation of dihomo-gamma-linoleate (DGLA, C20:3(n-6)) and eicosapentaenoate (EPA, C20:5(n-3)) to corresponding PGH1 and PGH3, the precursors of 1- and 3-series prostaglandins (By similarity). In an alternative pathway of prostanoid biosynthesis, converts 2-arachidonoyl lysophopholipids to prostanoid lysophopholipids, which are then hydrolyzed by intracellular phospholipases to release free prostanoids (By similarity). Metabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response. Generates lipid mediators from n-3 and n-6 polyunsaturated fatty acids (PUFAs) via a lipoxygenase-type mechanism. Oxygenates PUFAs to hydroperoxy compounds and then reduces them to corresponding alcohols (By similarity). Plays a role in the generation of resolution phase interaction products (resolvins) during both sterile and infectious inflammation. Metabolizes docosahexaenoate (DHA, C22:6(n-3)) to 17R-HDHA, a precursor of the D-series resolvins (RvDs) (By similarity). As a component of the biosynthetic pathway of E-series resolvins (RvEs), converts eicosapentaenoate (EPA, C20:5(n-3)) primarily to 18S-HEPE that is further metabolized by ALOX5 and LTA4H to generate 18S-RvE1 and 18S-RvE2 (By similarity). In vascular endothelial cells, converts docosapentaenoate (DPA, C22:5(n-3)) to 13R-HDPA, a precursor for 13-series resolvins (RvTs) shown to activate macrophage phagocytosis during bacterial infection (By similarity). In activated leukocytes, contributes to oxygenation of hydroxyeicosatetraenoates (HETE) to diHETES (5,15-diHETE and 5,11-diHETE) (By similarity). During neuroinflammation, plays a role in neuronal secretion of specialized preresolving mediators (SPMs) 15R-lipoxin A4 that regulates phagocytic microglia (By similarity).|||Endoplasmic reticulum membrane|||Homodimer.|||Microsome membrane|||Nucleus inner membrane|||Nucleus outer membrane|||PTGS1 and PTGS2 are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin and ibuprofen. Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation. Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic events, as well as the development of colon cancer and Alzheimer's disease. PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration.|||S-nitrosylation by NOS2 (iNOS) activates enzyme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-525.|||The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. The peroxidase reaction occurs at a heme-containing active site located near the protein surface. The nonsteroidal anti-inflammatory drugs (NSAIDs) binding site corresponds to the cyclooxygenase active site. http://togogenome.org/gene/9940:CD9 ^@ http://purl.uniprot.org/uniprot/B0LXL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/9940:BLOC1S5 ^@ http://purl.uniprot.org/uniprot/W5Q6I4 ^@ Function|||Similarity ^@ Belongs to the BLOC1S5 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). http://togogenome.org/gene/9940:MRPS24 ^@ http://purl.uniprot.org/uniprot/A0A6P3EP96|||http://purl.uniprot.org/uniprot/W5PVC5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Mitochondrion|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMCC3 ^@ http://purl.uniprot.org/uniprot/A0A836D4Y2|||http://purl.uniprot.org/uniprot/W5Q327 ^@ Caution|||Similarity ^@ Belongs to the TEX28 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRAPPC8 ^@ http://purl.uniprot.org/uniprot/A0A6P3TG28 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SYTL2 ^@ http://purl.uniprot.org/uniprot/A0A6P3T8C3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:S100A3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5Z5|||http://purl.uniprot.org/uniprot/A0A6P3TJ11 ^@ Caution|||Similarity ^@ Belongs to the S-100 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ABCG8 ^@ http://purl.uniprot.org/uniprot/A0A6P3TJ36|||http://purl.uniprot.org/uniprot/W5P9N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9940:SMCO1 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZP7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AMDHD1 ^@ http://purl.uniprot.org/uniprot/W5PR50 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. HutI family. http://togogenome.org/gene/9940:TRPV6 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5A4 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SEMA4D ^@ http://purl.uniprot.org/uniprot/W5PD26 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:ZNF169 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6T6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPP1R8 ^@ http://purl.uniprot.org/uniprot/A0A836D736 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MSRB3 ^@ http://purl.uniprot.org/uniprot/A0A6P7DWT5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/9940:CCDC65 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBL9|||http://purl.uniprot.org/uniprot/A0A6P7DWJ7 ^@ Caution|||Subcellular Location Annotation|||Subunit ^@ Component of the nexin-dynein regulatory complex (N-DRC).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||flagellum axoneme http://togogenome.org/gene/9940:LACC1 ^@ http://purl.uniprot.org/uniprot/W5PCC0 ^@ Similarity ^@ Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. http://togogenome.org/gene/9940:HDAC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E958|||http://purl.uniprot.org/uniprot/W5QIG5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPS5 ^@ http://purl.uniprot.org/uniprot/W5P114 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/9940:DUSP4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEQ5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FPGS ^@ http://purl.uniprot.org/uniprot/W5PPC9 ^@ Cofactor|||Function|||Similarity ^@ A monovalent cation.|||Belongs to the folylpolyglutamate synthase family.|||Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. http://togogenome.org/gene/9940:CRHBP ^@ http://purl.uniprot.org/uniprot/Q28557 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRF-binding protein family.|||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|||Secreted http://togogenome.org/gene/9940:ABCF3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E524 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101106855 ^@ http://purl.uniprot.org/uniprot/A0A836A0U0|||http://purl.uniprot.org/uniprot/W5PMC5 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101104222 ^@ http://purl.uniprot.org/uniprot/W5PDX3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9940:CKS1B ^@ http://purl.uniprot.org/uniprot/A0A6P3YGW9|||http://purl.uniprot.org/uniprot/W5NZA3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRPF19 ^@ http://purl.uniprot.org/uniprot/A0A6P3EK25|||http://purl.uniprot.org/uniprot/W5Q1Z7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PRP19 family.|||Homotetramer.|||Lipid droplet|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.|||nucleoplasm http://togogenome.org/gene/9940:AKAP5 ^@ http://purl.uniprot.org/uniprot/W5NS86 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:SGCG ^@ http://purl.uniprot.org/uniprot/W5PVB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9940:CLIC2 ^@ http://purl.uniprot.org/uniprot/W5P0K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Membrane http://togogenome.org/gene/9940:DCAF4 ^@ http://purl.uniprot.org/uniprot/A0A6P3YMJ3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101106791 ^@ http://purl.uniprot.org/uniprot/A0A6P3EM17|||http://purl.uniprot.org/uniprot/W5Q6F0 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PGM3 ^@ http://purl.uniprot.org/uniprot/W5PC32 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. http://togogenome.org/gene/9940:IRF2 ^@ http://purl.uniprot.org/uniprot/Q9N137 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9940:DHX35 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJ16 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATP6V0C ^@ http://purl.uniprot.org/uniprot/A0A835ZJL3|||http://purl.uniprot.org/uniprot/O18882 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Ubiquitinated by RNF182, leading to its degradation via the ubiquitin-proteasome pathway.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity). Interacts with the V0 complex V-ATPase subunit a4 ATP6V0A4 (By similarity). Interacts with LASS2 (By similarity). Interacts with RNF182; this interaction leads to ubiquitination and degradation via the proteasome pathway (By similarity).|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||Vacuole membrane|||clathrin-coated vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/9940:IL27RA ^@ http://purl.uniprot.org/uniprot/A0A6P3E4G6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPL10 ^@ http://purl.uniprot.org/uniprot/A8D8X1 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Citrullinated by PADI4.|||Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).|||Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.|||Ufmylated by UFL1. http://togogenome.org/gene/9940:PAX2 ^@ http://purl.uniprot.org/uniprot/D5GSQ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:CSNK1G1 ^@ http://purl.uniprot.org/uniprot/W5QHU6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/9940:PSENEN ^@ http://purl.uniprot.org/uniprot/A0A6P3ECB7|||http://purl.uniprot.org/uniprot/A0A6P3EJM6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PEN-2 family.|||Golgi stack membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM115 ^@ http://purl.uniprot.org/uniprot/A0A836CSW7 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ESR2 ^@ http://purl.uniprot.org/uniprot/Q9TU15 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA1, NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with UBE1C and AKAP13. Interacts with DNTTIP2. Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes. Interacts with DNAAF4. Interacts with PRMT2. Interacts with CCAR2 (via N-terminus) in a ligand-independent manner. Interacts with RBM39, in the presence of estradiol (E2).|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.|||Nucleus|||Phosphorylation at Ser-84 and Ser-102 recruits NCOA1. http://togogenome.org/gene/9940:NR3C2 ^@ http://purl.uniprot.org/uniprot/A0A835ZQ19 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TUBA4A ^@ http://purl.uniprot.org/uniprot/A0A6P3CX09|||http://purl.uniprot.org/uniprot/C5ISA2 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains (PubMed:6504138, PubMed:2207090, PubMed:7704569). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:6504138, PubMed:2207090, PubMed:7704569). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:6504138, PubMed:2207090, PubMed:7704569).|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/9940:NDUFAF3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EPJ3|||http://purl.uniprot.org/uniprot/W5Q261 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Membrane|||Mitochondrion inner membrane|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HAUS8 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4E9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC5A8 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAX0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OCLN ^@ http://purl.uniprot.org/uniprot/A0A6P3T1C2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.|||Membrane|||tight junction http://togogenome.org/gene/9940:MGST3 ^@ http://purl.uniprot.org/uniprot/A0A836D8C3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NCBP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6U6|||http://purl.uniprot.org/uniprot/W5QGM3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRM NCBP2 family.|||Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.|||Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PDSS1 ^@ http://purl.uniprot.org/uniprot/W5Q3V9 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9940:UBE2D3 ^@ http://purl.uniprot.org/uniprot/A0A836A9D5|||http://purl.uniprot.org/uniprot/W5NX15 ^@ Caution|||Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101112509 ^@ http://purl.uniprot.org/uniprot/W5Q5B9 ^@ Function ^@ Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. http://togogenome.org/gene/9940:ZBTB44 ^@ http://purl.uniprot.org/uniprot/A0A6P3YPH4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDK4 ^@ http://purl.uniprot.org/uniprot/A0A836D7X7|||http://purl.uniprot.org/uniprot/B2MVY4|||http://purl.uniprot.org/uniprot/W5P5K6 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily.|||Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||Both phosphorylation at Thr-172 and binding of a D-type cyclin are necessary for enzymatic activity. Full activation of the cyclin-D-CDK4 complex appears to require other factors such as recruitment of the substrate via a substrate recruitment motif, and/or formation of the CDKN1B ternary complex. Inhibited by INK4 family members. In resting cells, the non-tyrosine-phosphorylated form of CDKN1B prevents phosphorylation at Thr-172 and inactivation, while, in proliferating cells, tyrosine phosphorylation of CDKN1B allows phosphorylation of Thr-172 of CDK4 and subsequennt activation.|||Component of the D-CDK4 complex, composed of CDK4 and some D-type G1 cyclin (CCND1, CCND2 or CCND3). Interacts directly in the complex with CCND1, CCND2 or CCND3. Interacts with SEI1 and ZNF655. Forms a ternary complex, cyclin D-CDK4-CDKN1B, involved in modulating CDK4 enzymatic activity. Interacts directly with CDKN1B (phosphorylated on 'Tyr-88' and 'Tyr-89'); the interaction allows assembly of the cyclin D-CDK4 complex, Thr-172 phosphorylation, nuclear translocation and enhances the cyclin D-CDK4 complex activity. CDK4 activity is either inhibited or enhanced depending on stoichiometry of complex. The non-tyrosine-phosphorylated form of CDKN1B prevents T-loop phosphorylation of CDK4 producing inactive CDK4. Interacts (unphosphorylated form) with CDK2. Also forms ternary complexes with CDKN1A or CDKN2A. Interacts directly with CDKN1A (via its N-terminal); the interaction promotes the assembly of the cyclin D-CDK4 complex, its nuclear translocation and promotes the cyclin D-dependent enzyme activity of CDK4. Interacts with FNIP1 and FNIP2.|||Cytoplasm|||Nucleus|||Nucleus membrane|||Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101111391 ^@ http://purl.uniprot.org/uniprot/W5PCF4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:TMEM256 ^@ http://purl.uniprot.org/uniprot/W5PU46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM256 family.|||Membrane http://togogenome.org/gene/9940:PRP1 ^@ http://purl.uniprot.org/uniprot/A8QW37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/9940:ROCK1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EG18|||http://purl.uniprot.org/uniprot/W5PGB5 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by RHOA binding. Inhibited by Y-27632.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||Homodimer.|||Membrane|||Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IL6ST ^@ http://purl.uniprot.org/uniprot/W5PCA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9940:TRMT112 ^@ http://purl.uniprot.org/uniprot/A0A6P3EK65|||http://purl.uniprot.org/uniprot/W5PA68 ^@ Caution|||Similarity ^@ Belongs to the TRM112 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PYURF ^@ http://purl.uniprot.org/uniprot/A0A6P3EDV7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101118639 ^@ http://purl.uniprot.org/uniprot/W5PT87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:TLR3 ^@ http://purl.uniprot.org/uniprot/B5DC88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9940:CXCL13 ^@ http://purl.uniprot.org/uniprot/A0A6P3E707|||http://purl.uniprot.org/uniprot/W5Q8I5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GPR63 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6R6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDC40 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGT5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PSMD4 ^@ http://purl.uniprot.org/uniprot/A0A6P3TJJ6|||http://purl.uniprot.org/uniprot/A7UHZ2 ^@ Caution|||Similarity ^@ Belongs to the proteasome subunit S5A family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZFAND6 ^@ http://purl.uniprot.org/uniprot/A0A6P3EI62 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FKBP5 ^@ http://purl.uniprot.org/uniprot/A0A6P3YN75|||http://purl.uniprot.org/uniprot/A0A6P3YNB0 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GARS1 ^@ http://purl.uniprot.org/uniprot/W5PDU8 ^@ Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Homodimer. http://togogenome.org/gene/9940:TADA3 ^@ http://purl.uniprot.org/uniprot/W5P835 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGG1 family.|||Nucleus http://togogenome.org/gene/9940:LOC101110066 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBJ6 ^@ Caution|||Similarity ^@ Belongs to the cytochrome c oxidase VIIa family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OOEP ^@ http://purl.uniprot.org/uniprot/U3N063 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KHDC1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9940:PCMTD1 ^@ http://purl.uniprot.org/uniprot/A0A6P7ECA1 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9940:RPS4X ^@ http://purl.uniprot.org/uniprot/A0A6P3ES39|||http://purl.uniprot.org/uniprot/W5PFW3 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:THOC7 ^@ http://purl.uniprot.org/uniprot/A0A6P3YMW8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC7 family.|||Nucleus|||Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. http://togogenome.org/gene/9940:TDO2 ^@ http://purl.uniprot.org/uniprot/A0A835ZQN1|||http://purl.uniprot.org/uniprot/W5PAB0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer. Dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARHGEF6 ^@ http://purl.uniprot.org/uniprot/W5PMS0 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/9940:KATNAL2 ^@ http://purl.uniprot.org/uniprot/W5NZX3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.|||Cytoplasm|||Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9940:SH2D1A ^@ http://purl.uniprot.org/uniprot/W5PXC9 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. http://togogenome.org/gene/9940:DES ^@ http://purl.uniprot.org/uniprot/A0A6P3E6L1|||http://purl.uniprot.org/uniprot/W5QG29 ^@ Caution|||Similarity ^@ Belongs to the intermediate filament family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TOMM40 ^@ http://purl.uniprot.org/uniprot/A0A836CX65 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C13H20orf85 ^@ http://purl.uniprot.org/uniprot/A0A836A5M6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101111035 ^@ http://purl.uniprot.org/uniprot/W5P3F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9940:CASTOR2 ^@ http://purl.uniprot.org/uniprot/A0A6P3ELT7 ^@ Caution|||Similarity ^@ Belongs to the GATS family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HEPHL1 ^@ http://purl.uniprot.org/uniprot/W5NV45 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9940:KRT84 ^@ http://purl.uniprot.org/uniprot/A0A836AJA2|||http://purl.uniprot.org/uniprot/W5Q6J4 ^@ Caution|||Similarity ^@ Belongs to the intermediate filament family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ACTN2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EM26 ^@ Caution|||Similarity ^@ Belongs to the alpha-actinin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UTP23 ^@ http://purl.uniprot.org/uniprot/W5PLC6 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9940:EIF4G1 ^@ http://purl.uniprot.org/uniprot/A0A6P3T232|||http://purl.uniprot.org/uniprot/W5QHD4 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic initiation factor 4G family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DIABLO ^@ http://purl.uniprot.org/uniprot/W5PQ00 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9940:MMP14 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQP6|||http://purl.uniprot.org/uniprot/C8BKE2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Cytoplasm|||Melanosome|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101109452 ^@ http://purl.uniprot.org/uniprot/A0A6P3E892 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:P2RY1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E732|||http://purl.uniprot.org/uniprot/W5Q0R9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101102194 ^@ http://purl.uniprot.org/uniprot/A0A6P3EKZ6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATG4A ^@ http://purl.uniprot.org/uniprot/A0A6P3EHK0|||http://purl.uniprot.org/uniprot/W5QAR3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AIFM1 ^@ http://purl.uniprot.org/uniprot/W5Q1F6 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase family. http://togogenome.org/gene/9940:HEXA ^@ http://purl.uniprot.org/uniprot/B2LSM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 20 family.|||Lysosome http://togogenome.org/gene/9940:ARMCX1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFE0|||http://purl.uniprot.org/uniprot/A0A6P3TLD5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eutherian X-chromosome-specific Armcx family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:YIPF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TI43|||http://purl.uniprot.org/uniprot/W5P9J6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Late endosome membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/9940:CRABP1 ^@ http://purl.uniprot.org/uniprot/W5NRM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm|||Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors. http://togogenome.org/gene/9940:MINDY1 ^@ http://purl.uniprot.org/uniprot/W5QIB3 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/9940:TASP1 ^@ http://purl.uniprot.org/uniprot/W5PN10 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/9940:CPE ^@ http://purl.uniprot.org/uniprot/W5Q3Q3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M14 family.|||Interacts with Secretogranin III/SCG3.|||Membrane|||Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.|||secretory vesicle membrane http://togogenome.org/gene/9940:LOC101112657 ^@ http://purl.uniprot.org/uniprot/A0A6P7EGP6|||http://purl.uniprot.org/uniprot/A0A6P7EH18 ^@ Caution|||Function ^@ The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ACTB ^@ http://purl.uniprot.org/uniprot/D7RIF5|||http://purl.uniprot.org/uniprot/P60713 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.|||Belongs to the actin family.|||ISGylated.|||In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.|||Methylated at His-73 by SETD3 (By similarity). Methylation at His-73 is required for smooth muscle contraction of the laboring uterus during delivery (By similarity).|||Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.|||N-terminal acetylation by NAA80 affects actin filament depolymerization and elongation, including elongation driven by formins. In contrast, filament nucleation by the Arp2/3 complex is not affected.|||Nucleus|||Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization.|||Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with XPO6 and EMD. Interacts with ERBB2. Interacts with GCSAM (By similarity). Interacts with TBC1D21. Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (By similarity). Interacts with DHX9 (via C-terminus); this interaction is direct and mediates the attachment to nuclear ribonucleoprotein complexes. Interacts with FAM107A (By similarity).|||cytoskeleton http://togogenome.org/gene/9940:SGTB ^@ http://purl.uniprot.org/uniprot/A0A6P3EN80|||http://purl.uniprot.org/uniprot/W5P7Z0 ^@ Caution|||Similarity ^@ Belongs to the SGT family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NDNF ^@ http://purl.uniprot.org/uniprot/W5Q172 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9940:NDRG2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YK30|||http://purl.uniprot.org/uniprot/A0A6P3YM99|||http://purl.uniprot.org/uniprot/A0A6P7E451 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDRG family.|||Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OLFM3 ^@ http://purl.uniprot.org/uniprot/W5QAR8 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9940:MPC2 ^@ http://purl.uniprot.org/uniprot/W5PS50 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9940:MET ^@ http://purl.uniprot.org/uniprot/Q09YI9 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autophosphorylated in response to ligand binding on Tyr-1235 and Tyr-1236 in the kinase domain leading to further phosphorylation of Tyr-1350 and Tyr-1357 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1350 and Tyr-1366. Dephosphorylated by PTPN1 and PTPN2 (By similarity).|||Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1357, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity.|||In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity (By similarity).|||Membrane|||Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).|||The beta-propeller Sema domain mediates binding to HGF.|||The kinase domain is involved in SPSB1 binding.|||Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity). http://togogenome.org/gene/9940:MOV10 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6V9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.|||P-body|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC105601956 ^@ http://purl.uniprot.org/uniprot/B6CGU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.|||Secreted http://togogenome.org/gene/9940:PFKFB1 ^@ http://purl.uniprot.org/uniprot/W5P7A7 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9940:TIPIN ^@ http://purl.uniprot.org/uniprot/W5Q9V8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSM3 family.|||Nucleus|||Plays an important role in the control of DNA replication and the maintenance of replication fork stability. http://togogenome.org/gene/9940:POLA1 ^@ http://purl.uniprot.org/uniprot/W5Q828 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/9940:LOC101104526 ^@ http://purl.uniprot.org/uniprot/W5PNG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:PPP1R1C ^@ http://purl.uniprot.org/uniprot/W5Q5R3 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/9940:TIMP2 ^@ http://purl.uniprot.org/uniprot/A0A6P9FRF3|||http://purl.uniprot.org/uniprot/C8BKC3 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the protease inhibitor I35 (TIMP) family.|||Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IGFBP3 ^@ http://purl.uniprot.org/uniprot/C0LQH2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9940:LOC101110457 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJI1|||http://purl.uniprot.org/uniprot/A0A836CTR2 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LZIC ^@ http://purl.uniprot.org/uniprot/W5PA76 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/9940:LOC101108434 ^@ http://purl.uniprot.org/uniprot/W5PJ38 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:CDC42EP3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TE15|||http://purl.uniprot.org/uniprot/A0A6P7DWS2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101113462 ^@ http://purl.uniprot.org/uniprot/W5PQA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/9940:TEF ^@ http://purl.uniprot.org/uniprot/A0A6P3YJS7|||http://purl.uniprot.org/uniprot/B6CM54|||http://purl.uniprot.org/uniprot/D7RFH8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KNG1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6V8|||http://purl.uniprot.org/uniprot/W5QH45|||http://purl.uniprot.org/uniprot/W5QH46 ^@ Caution|||Subcellular Location Annotation ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||extracellular space http://togogenome.org/gene/9940:SERINC3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YL25 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RAG2 ^@ http://purl.uniprot.org/uniprot/W5PL96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAG2 family.|||Nucleus http://togogenome.org/gene/9940:ATP2A2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TGF4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:INHBA ^@ http://purl.uniprot.org/uniprot/P43032 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3 (By similarity).|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9940:PDE7A ^@ http://purl.uniprot.org/uniprot/A0A6P3E905 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MCMDC2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YMZ9|||http://purl.uniprot.org/uniprot/W5Q932 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome http://togogenome.org/gene/9940:ENTPD3 ^@ http://purl.uniprot.org/uniprot/A0A6P3T732 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9940:MTERF2 ^@ http://purl.uniprot.org/uniprot/W5QAV5 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9940:ERAL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGZ0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Membrane|||Mitochondrion inner membrane|||Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:USP30 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENR6|||http://purl.uniprot.org/uniprot/W5Q6F3 ^@ Caution|||Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MAPK1IP1L ^@ http://purl.uniprot.org/uniprot/W5QIV6 ^@ Similarity ^@ Belongs to the MISS family. http://togogenome.org/gene/9940:LOC101110208 ^@ http://purl.uniprot.org/uniprot/W5P8Y1 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9940:LOC101103187 ^@ http://purl.uniprot.org/uniprot/W5PWI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Cytoplasm|||nucleolus|||nucleoplasm http://togogenome.org/gene/9940:LOC101114275 ^@ http://purl.uniprot.org/uniprot/A0A6P3YMK6|||http://purl.uniprot.org/uniprot/W5PTS4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RRP15 ^@ http://purl.uniprot.org/uniprot/W5PPI2 ^@ Similarity ^@ Belongs to the RRP15 family. http://togogenome.org/gene/9940:USE1 ^@ http://purl.uniprot.org/uniprot/W5Q8P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the USE1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9940:LOC101116125 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHD6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARHGAP19 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQX3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101117745 ^@ http://purl.uniprot.org/uniprot/W5Q9X0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:PIAS3 ^@ http://purl.uniprot.org/uniprot/A0A6P3THS1 ^@ Caution|||Similarity ^@ Belongs to the PIAS family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DYNLT2 ^@ http://purl.uniprot.org/uniprot/W5P4V1 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9940:GTF3C3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E1W5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TSEN2 ^@ http://purl.uniprot.org/uniprot/W5Q3J0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.|||Nucleus http://togogenome.org/gene/9940:LOC101119878 ^@ http://purl.uniprot.org/uniprot/W5PET1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9940:DCAF7 ^@ http://purl.uniprot.org/uniprot/A0A6P3EIZ3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101117413 ^@ http://purl.uniprot.org/uniprot/W5NTA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:NAGK ^@ http://purl.uniprot.org/uniprot/W5PNZ1 ^@ Similarity ^@ Belongs to the eukaryotic-type N-acetylglucosamine kinase family. http://togogenome.org/gene/9940:LOC101120653 ^@ http://purl.uniprot.org/uniprot/W5QGT2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9940:SCN3B ^@ http://purl.uniprot.org/uniprot/A0A6P3YMX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.|||Membrane|||Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. http://togogenome.org/gene/9940:PRL ^@ http://purl.uniprot.org/uniprot/P01240 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the somatotropin/prolactin family.|||Interacts with PRLR.|||Prolactin acts primarily on the mammary gland by promoting lactation, mammogenesis, mitogenesis and osmoregulation.|||Secreted http://togogenome.org/gene/9940:GLDC ^@ http://purl.uniprot.org/uniprot/A0A6P3E8A9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvP family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OGN ^@ http://purl.uniprot.org/uniprot/A0A6P3E7U7|||http://purl.uniprot.org/uniprot/W5PEL2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.|||Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||extracellular matrix http://togogenome.org/gene/9940:TXNDC16 ^@ http://purl.uniprot.org/uniprot/A0A835ZZS5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SUMF2 ^@ http://purl.uniprot.org/uniprot/W5PK71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase-modifying factor family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9940:NUDT11 ^@ http://purl.uniprot.org/uniprot/A0A835ZIW8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC15A1 ^@ http://purl.uniprot.org/uniprot/Q9BDH7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/9940:NSG1 ^@ http://purl.uniprot.org/uniprot/A0A836D4S8 ^@ Caution|||Similarity ^@ Belongs to the NSG family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OST4 ^@ http://purl.uniprot.org/uniprot/A0A6P3E2H0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OST4 family.|||Endoplasmic reticulum membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101113728 ^@ http://purl.uniprot.org/uniprot/A0A6P3TM89 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers.|||Belongs to the clusterin family.|||Endoplasmic reticulum|||Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.|||Membrane|||Microsome|||Mitochondrion membrane|||Nucleus|||Secreted|||chromaffin granule|||cytosol|||perinuclear region http://togogenome.org/gene/9940:IFNAR2 ^@ http://purl.uniprot.org/uniprot/Q95207 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the type II cytokine receptor family.|||Cell membrane|||Expressed in the endometrium. Expressed in all tissues examined except conceptus at day 15 of pregnancy.|||Heterodimer with IFNAR1; forming the receptor for type I interferon. Interacts with the transcriptional factors STAT1 and STAT2. Interacts with JAK1. Interacts with USP18; indirectly via STAT2, it negatively regulates the assembly of the ternary interferon-IFNAR1-IFNAR2 complex and therefore type I interferon signaling.|||Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-340 or Tyr-525 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types (By similarity).|||Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. http://togogenome.org/gene/9940:AFF4 ^@ http://purl.uniprot.org/uniprot/A0A6P7E5T6 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/9940:CHCHD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGS2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101117789 ^@ http://purl.uniprot.org/uniprot/W5PFG7 ^@ Similarity ^@ Belongs to the SERF family. http://togogenome.org/gene/9940:NFKBIE ^@ http://purl.uniprot.org/uniprot/A0A6P3EEU1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KCNAB2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TLT5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||axon|||cytoskeleton|||synaptosome http://togogenome.org/gene/9940:LOC101113508 ^@ http://purl.uniprot.org/uniprot/W5PZ54 ^@ Similarity ^@ Belongs to the SCO1/2 family. http://togogenome.org/gene/9940:EMP1 ^@ http://purl.uniprot.org/uniprot/W5QI16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9940:TMEM50A ^@ http://purl.uniprot.org/uniprot/A0A6P3E264|||http://purl.uniprot.org/uniprot/A0A6P3E9C6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CFAP418 ^@ http://purl.uniprot.org/uniprot/A0A6P3E977|||http://purl.uniprot.org/uniprot/W5P6M8 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in photoreceptor outer segment disk morphogenesis.|||Photoreceptor inner segment|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101117971 ^@ http://purl.uniprot.org/uniprot/W5PXX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9940:KCNE1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6C6 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9940:GOSR2 ^@ http://purl.uniprot.org/uniprot/W5PM29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOSR2 family.|||Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.|||Membrane http://togogenome.org/gene/9940:CLDN17 ^@ http://purl.uniprot.org/uniprot/A0A6P3TXE1|||http://purl.uniprot.org/uniprot/W5NSG1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||tight junction http://togogenome.org/gene/9940:MRPL47 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZU0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL29 family.|||Mitochondrion|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101119947 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFK4|||http://purl.uniprot.org/uniprot/W5PSF4 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.|||May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPFIBP1 ^@ http://purl.uniprot.org/uniprot/A0A836AAW7 ^@ Caution|||Similarity ^@ Belongs to the liprin family. Liprin-beta subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DCTN1 ^@ http://purl.uniprot.org/uniprot/W5PSJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin 150 kDa subunit family.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9940:SAP25 ^@ http://purl.uniprot.org/uniprot/A0A6P3T9Z5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DKC1 ^@ http://purl.uniprot.org/uniprot/B7TJ12 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/9940:AP1G2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFK7|||http://purl.uniprot.org/uniprot/W5QDA7 ^@ Caution|||Similarity ^@ Belongs to the adaptor complexes large subunit family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PDYN ^@ http://purl.uniprot.org/uniprot/L7PA78 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.|||Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Leumorphin has a typical opiod activity and may have anti-apoptotic effect.|||Secreted http://togogenome.org/gene/9940:RAD52 ^@ http://purl.uniprot.org/uniprot/W5PSD3 ^@ Similarity ^@ Belongs to the RAD52 family. http://togogenome.org/gene/9940:CNEP1R1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFB9|||http://purl.uniprot.org/uniprot/W5Q6I9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNEP1R1 family.|||Cytoplasm|||Membrane|||Nucleus membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRAPPC2L ^@ http://purl.uniprot.org/uniprot/A0A6P3YQC2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||perinuclear region http://togogenome.org/gene/9940:MMP13 ^@ http://purl.uniprot.org/uniprot/A0A6P9FRF2|||http://purl.uniprot.org/uniprot/C8BKE3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KBTBD2 ^@ http://purl.uniprot.org/uniprot/A0A836A7P0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC34A1 ^@ http://purl.uniprot.org/uniprot/O97704 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Interacts via its C-terminal region with PDZK2. Interacts with SLC9A3R1.|||Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic. http://togogenome.org/gene/9940:DDX59 ^@ http://purl.uniprot.org/uniprot/W5Q471 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX59 subfamily. http://togogenome.org/gene/9940:AWAT2 ^@ http://purl.uniprot.org/uniprot/A0A6P3ESV7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KIF11 ^@ http://purl.uniprot.org/uniprot/A0A836CR49|||http://purl.uniprot.org/uniprot/W5NR75 ^@ Caution|||Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IFI35 ^@ http://purl.uniprot.org/uniprot/W5P2S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NMI family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9940:RPS14 ^@ http://purl.uniprot.org/uniprot/A0A6P3E642 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uS11 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NT5DC1 ^@ http://purl.uniprot.org/uniprot/A0A836AC68|||http://purl.uniprot.org/uniprot/W5PI06 ^@ Caution|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RBM28 ^@ http://purl.uniprot.org/uniprot/A0A836A7G5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NEIL2 ^@ http://purl.uniprot.org/uniprot/A0A6P7DNS3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HDDC2 ^@ http://purl.uniprot.org/uniprot/W5PDL8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HDDC2 family.|||Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).|||Homodimer. http://togogenome.org/gene/9940:ELP4 ^@ http://purl.uniprot.org/uniprot/W5Q3F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9940:HOXC6 ^@ http://purl.uniprot.org/uniprot/P49925 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9940:SLC7A6OS ^@ http://purl.uniprot.org/uniprot/A0A836A5N3|||http://purl.uniprot.org/uniprot/W5NZM8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IWR1/SLC7A6OS family.|||Cytoplasm|||Directs RNA polymerase II nuclear import.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM168 ^@ http://purl.uniprot.org/uniprot/W5NVP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM168 family.|||Membrane http://togogenome.org/gene/9940:PDE5A ^@ http://purl.uniprot.org/uniprot/A0A6P3E6K5|||http://purl.uniprot.org/uniprot/W5Q3B6|||http://purl.uniprot.org/uniprot/W5Q3B7 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IGF2 ^@ http://purl.uniprot.org/uniprot/A0A6P7DAJ1|||http://purl.uniprot.org/uniprot/P10764 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Interacts with MYORG; this interaction is required for IGF2 secretion. Interacts with integrins ITGAV:ITGB3 and ITGA6:ITGB4; integrin-binding is required for IGF2 signaling.|||Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.|||Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2.|||Secreted|||The IGF2 locus is imprinted. Paternal inherited gene is expressed, while the maternal inherited gene is imprinted, hence silenced.|||The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity).|||The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate. http://togogenome.org/gene/9940:CX3CR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC29|||http://purl.uniprot.org/uniprot/W5PX52 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FANCG ^@ http://purl.uniprot.org/uniprot/A0A836AJ36 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LSM1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ES80|||http://purl.uniprot.org/uniprot/W5NT81 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Cytoplasm|||Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.|||P-body|||Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DLL4 ^@ http://purl.uniprot.org/uniprot/W5QGG2 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/9940:AR ^@ http://purl.uniprot.org/uniprot/S5U7M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9940:SS18L2 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQF5|||http://purl.uniprot.org/uniprot/B9VH03 ^@ Caution|||Similarity ^@ Belongs to the SS18 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SMIM13 ^@ http://purl.uniprot.org/uniprot/A0A6P3YS55 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:WDR33 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9I0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FIBIN ^@ http://purl.uniprot.org/uniprot/A0A6P3EGP4 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FIBIN family.|||Endoplasmic reticulum|||Golgi apparatus|||Homodimer; disulfide-linked. Seems to also exist as monomers.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KEF53_p03 ^@ http://purl.uniprot.org/uniprot/A0A0E3JPI4|||http://purl.uniprot.org/uniprot/O78756 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 5 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9940:NXNL2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YFR1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRAFD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHX1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATP1B1 ^@ http://purl.uniprot.org/uniprot/A0A6P7EJR7|||http://purl.uniprot.org/uniprot/P05028 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the X(+)/potassium ATPases subunit beta family.|||Cell membrane|||Glutathionylated (By similarity). N-glycosylated (By similarity).|||Involved in cell adhesion and establishing epithelial cell polarity.|||Membrane|||The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with catalytic subunit ATP12A (By similarity). Interacts with regulatory subunit FXYD1 (By similarity). Interacts with regulatory subunit FXYD3 (By similarity). Interacts with NKAIN1, NKAIN2 and NKAIN4 (By similarity). Interacts with MLC1. Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM. Interacts with KIRREL3 (By similarity). Interacts with OBSCN (via protein kinase domain 1) (By similarity). Interacts with TRAF3 and TRAF6 (By similarity).|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1.|||sarcolemma http://togogenome.org/gene/9940:UFC1 ^@ http://purl.uniprot.org/uniprot/W5PIN1 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.|||E1-like enzyme which specifically catalyzes the second step in ufmylation. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. http://togogenome.org/gene/9940:GPATCH11 ^@ http://purl.uniprot.org/uniprot/W5PJD9 ^@ Similarity ^@ Belongs to the GPATCH11 family. http://togogenome.org/gene/9940:MAPK9 ^@ http://purl.uniprot.org/uniprot/A0A836A537 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ADCYAP1 ^@ http://purl.uniprot.org/uniprot/P16613 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucagon family.|||Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).|||Interacts with ADCYAP1R1 (via N-terminal extracellular domain).|||Secreted http://togogenome.org/gene/9940:KCNV2 ^@ http://purl.uniprot.org/uniprot/W5PUZ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:MPV17 ^@ http://purl.uniprot.org/uniprot/A0A836D761 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FEV ^@ http://purl.uniprot.org/uniprot/A0A6P3EA45 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CACNG3 ^@ http://purl.uniprot.org/uniprot/W5Q8C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane http://togogenome.org/gene/9940:FXYD5 ^@ http://purl.uniprot.org/uniprot/W5P3Q2 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/9940:NDUFB8 ^@ http://purl.uniprot.org/uniprot/D5M8S1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB8 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9940:CAV3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EN41 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||caveola|||sarcolemma http://togogenome.org/gene/9940:FBXL4 ^@ http://purl.uniprot.org/uniprot/A0A6P3TGE8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RABL3 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZM4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101116799 ^@ http://purl.uniprot.org/uniprot/W5PHS2 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9940:LOC101119456 ^@ http://purl.uniprot.org/uniprot/W5Q4D7 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9940:ASZ1 ^@ http://purl.uniprot.org/uniprot/Q09YI3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity). http://togogenome.org/gene/9940:MC1R ^@ http://purl.uniprot.org/uniprot/A0A835ZSD6|||http://purl.uniprot.org/uniprot/E4WMB4|||http://purl.uniprot.org/uniprot/O19037 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with OPN3; the interaction results in a decrease in MC1R-mediated cAMP signaling and ultimately a decrease in melanin production in melanocytes.|||Membrane|||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.|||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDIPT ^@ http://purl.uniprot.org/uniprot/A0A6P3EQV3|||http://purl.uniprot.org/uniprot/W5P5G0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:P3H1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TIG0|||http://purl.uniprot.org/uniprot/W5QGX4 ^@ Caution|||Similarity ^@ Belongs to the leprecan family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MYL4 ^@ http://purl.uniprot.org/uniprot/A0A6P3TLA0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IDH1 ^@ http://purl.uniprot.org/uniprot/Q6XUZ5 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-374 dramatically reduces catalytic activity.|||Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (By similarity). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (By similarity). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity).|||Homodimer.|||cytosol http://togogenome.org/gene/9940:LOC101106373 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENW4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NSF ^@ http://purl.uniprot.org/uniprot/W5PMS2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. http://togogenome.org/gene/9940:BAG5 ^@ http://purl.uniprot.org/uniprot/A0A836CUU7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MDM1 ^@ http://purl.uniprot.org/uniprot/W5NTA6|||http://purl.uniprot.org/uniprot/W5NTA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM1 family.|||Nucleus|||centriole http://togogenome.org/gene/9940:TMEM170B ^@ http://purl.uniprot.org/uniprot/W5PZF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/9940:ORC2 ^@ http://purl.uniprot.org/uniprot/W5Q5B2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC2 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Component of the origin recognition complex (ORC).|||Nucleus http://togogenome.org/gene/9940:GSDME ^@ http://purl.uniprot.org/uniprot/W5PM41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:MRPL10 ^@ http://purl.uniprot.org/uniprot/A0A6P3EA93|||http://purl.uniprot.org/uniprot/W5PDX6 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SFTPC ^@ http://purl.uniprot.org/uniprot/A0A6P3CWK6|||http://purl.uniprot.org/uniprot/Q9N276 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||surface film http://togogenome.org/gene/9940:CERS6 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8M1 ^@ Caution|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ST6GALNAC6 ^@ http://purl.uniprot.org/uniprot/A0A836AIM8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101120875 ^@ http://purl.uniprot.org/uniprot/W5Q1G8 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9940:SAT2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EA18 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AVP ^@ http://purl.uniprot.org/uniprot/B2KPN5 ^@ Similarity ^@ Belongs to the vasopressin/oxytocin family. http://togogenome.org/gene/9940:ADAMTS6 ^@ http://purl.uniprot.org/uniprot/A0A835ZYN8 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||extracellular matrix http://togogenome.org/gene/9940:LOC101106489 ^@ http://purl.uniprot.org/uniprot/A0A6P3TT55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:MYO1A ^@ http://purl.uniprot.org/uniprot/W5PD30 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9940:RNPC3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6S0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.|||Nucleus|||Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA. http://togogenome.org/gene/9940:LOC101111396 ^@ http://purl.uniprot.org/uniprot/A0A6P3EM04|||http://purl.uniprot.org/uniprot/W5PJZ5 ^@ Caution|||Similarity ^@ Belongs to the HHIP family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GCM2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EP40|||http://purl.uniprot.org/uniprot/W5Q1Q9 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TDRD7 ^@ http://purl.uniprot.org/uniprot/W5PNS6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TDRD7 family.|||Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.|||Cytoplasm|||Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1. http://togogenome.org/gene/9940:NUDT19 ^@ http://purl.uniprot.org/uniprot/W5P254 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/9940:LOC101118481 ^@ http://purl.uniprot.org/uniprot/A0A836ADJ9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SMC1B ^@ http://purl.uniprot.org/uniprot/A0A6P3TFJ5|||http://purl.uniprot.org/uniprot/W5QDN0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Chromosome|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ERCC8 ^@ http://purl.uniprot.org/uniprot/A0A6P3EN99 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RAB9A ^@ http://purl.uniprot.org/uniprot/C5IJ93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/9940:MLN ^@ http://purl.uniprot.org/uniprot/O18845 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the motilin family.|||Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.|||Secreted http://togogenome.org/gene/9940:LOC101116286 ^@ http://purl.uniprot.org/uniprot/W5QFL1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains (PubMed:6504138, PubMed:2207090, PubMed:7704569). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:6504138, PubMed:2207090, PubMed:7704569). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:6504138, PubMed:2207090, PubMed:7704569).|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/9940:CHAC2 ^@ http://purl.uniprot.org/uniprot/W5P231 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/9940:CD40 ^@ http://purl.uniprot.org/uniprot/A0A6P3EKT3|||http://purl.uniprot.org/uniprot/W5PEW0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C5H5orf63 ^@ http://purl.uniprot.org/uniprot/A0A836D1U4 ^@ Caution|||Similarity ^@ Belongs to the glutaredoxin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NRSN2 ^@ http://purl.uniprot.org/uniprot/A0A836CXZ9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CIPC ^@ http://purl.uniprot.org/uniprot/A0A6P3CWZ4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IFT27 ^@ http://purl.uniprot.org/uniprot/A0A6P3CWV2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NOS3 ^@ http://purl.uniprot.org/uniprot/Q4U3W6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NOS family.|||Binds 1 FAD.|||Binds 1 FMN.|||Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. http://togogenome.org/gene/9940:STIM1 ^@ http://purl.uniprot.org/uniprot/W5NU73 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9940:ETFDH ^@ http://purl.uniprot.org/uniprot/A0A835ZPU0|||http://purl.uniprot.org/uniprot/W5P1M1 ^@ Caution|||Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MPST ^@ http://purl.uniprot.org/uniprot/A0A836D855 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DSTN ^@ http://purl.uniprot.org/uniprot/A0A6P3YPG0 ^@ Caution|||Function|||Similarity ^@ Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.|||Belongs to the actin-binding proteins ADF family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RRAGC ^@ http://purl.uniprot.org/uniprot/C5IJ90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9940:ORMDL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E1H8|||http://purl.uniprot.org/uniprot/A0A6P3E9I6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Endoplasmic reticulum membrane|||Membrane|||Negative regulator of sphingolipid synthesis.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LYZ ^@ http://purl.uniprot.org/uniprot/A4Z8Q3 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 22 family.|||Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. http://togogenome.org/gene/9940:CYP2D6 ^@ http://purl.uniprot.org/uniprot/F1CGV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9940:MED6 ^@ http://purl.uniprot.org/uniprot/W5QJ79 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 6 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9940:SH3BGRL ^@ http://purl.uniprot.org/uniprot/A0A6P3EN38 ^@ Caution|||Similarity ^@ Belongs to the SH3BGR family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DIRAS2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8U7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101119509 ^@ http://purl.uniprot.org/uniprot/W5Q124 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9940:MID1IP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ESB0|||http://purl.uniprot.org/uniprot/A0A6P3TAS7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PATJ ^@ http://purl.uniprot.org/uniprot/W5PGV1 ^@ Subcellular Location Annotation ^@ Cell membrane|||tight junction http://togogenome.org/gene/9940:SST ^@ http://purl.uniprot.org/uniprot/A0A6P7DSS5|||http://purl.uniprot.org/uniprot/O46688 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||C-terminal amidation of the neuronostatin peptide is required for its biological activity, including for the regulation of mean arterial pressure.|||Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin.|||May enhance low-glucose-induced glucagon release by pancreatic alpha cells. This effect may be mediated by binding to GPR107 and PKA activation (By similarity). May regulate cardiac contractile function (By similarity). May compromise cardiomyocyte viability. In the central nervous system, may impair memory retention and may affect hippocampal excitability. May also have anxiolytic and anorexigenic effects. May play a role in arterial pressure regulation (By similarity). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (By similarity).|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STRN ^@ http://purl.uniprot.org/uniprot/A0A6P3E7C7|||http://purl.uniprot.org/uniprot/W5PK29 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat striatin family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C25H1orf131 ^@ http://purl.uniprot.org/uniprot/A0A835ZHB5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZNF410 ^@ http://purl.uniprot.org/uniprot/A0A836ADQ1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HSPA2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBB6|||http://purl.uniprot.org/uniprot/W5NSB0 ^@ Caution|||Similarity ^@ Belongs to the heat shock protein 70 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TAF4B ^@ http://purl.uniprot.org/uniprot/A0A6P3EDV4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF4 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OXSM ^@ http://purl.uniprot.org/uniprot/W5P1U9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.|||Mitochondrion http://togogenome.org/gene/9940:ERP44 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5U3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DNAJB14 ^@ http://purl.uniprot.org/uniprot/A0A6P3EA85 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PARP12 ^@ http://purl.uniprot.org/uniprot/A0A6P3TN32|||http://purl.uniprot.org/uniprot/W5PS68 ^@ Caution|||Similarity ^@ Belongs to the ARTD/PARP family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POLDIP3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3M9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101114847 ^@ http://purl.uniprot.org/uniprot/W5P834 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9940:AP3M1 ^@ http://purl.uniprot.org/uniprot/W5PFM2 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/9940:CAVIN4 ^@ http://purl.uniprot.org/uniprot/W5PCH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola|||sarcomere http://togogenome.org/gene/9940:TPD52 ^@ http://purl.uniprot.org/uniprot/W5PEN2 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9940:TBC1D25 ^@ http://purl.uniprot.org/uniprot/A0A6P3EF14 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101104426 ^@ http://purl.uniprot.org/uniprot/A0A6P3EL46 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GUCA2B ^@ http://purl.uniprot.org/uniprot/A0A6P3E4W2|||http://purl.uniprot.org/uniprot/W5QGN7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CD2BP2 ^@ http://purl.uniprot.org/uniprot/A0A836CRS4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GNPAT ^@ http://purl.uniprot.org/uniprot/W5NZ60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Peroxisome membrane http://togogenome.org/gene/9940:HSD17B7 ^@ http://purl.uniprot.org/uniprot/W5PMQ4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. http://togogenome.org/gene/9940:LOC101121936 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDG8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SRD5A3 ^@ http://purl.uniprot.org/uniprot/A0A836AAR3|||http://purl.uniprot.org/uniprot/W5NTG2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).|||Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KEF53_p11 ^@ http://purl.uniprot.org/uniprot/O78749|||http://purl.uniprot.org/uniprot/Q5MA75 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heme-copper respiratory oxidase family.|||Binds 2 heme A groups non-covalently per subunit.|||Binds a copper B center.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome (By similarity). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:27654913). As a newly synthesized protein, rapidly incorporates into a multi-subunit assembly intermediate in the inner membrane, called MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase) complex, whose core components are COA3/MITRAC12 and COX14. Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover. Interacts with TMEM177 in a COX20-dependent manner (By similarity).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9940:MFSD8 ^@ http://purl.uniprot.org/uniprot/A0A836A1M8|||http://purl.uniprot.org/uniprot/W5Q200 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZNF214 ^@ http://purl.uniprot.org/uniprot/A0A835ZZS8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AMIGO1 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZ84|||http://purl.uniprot.org/uniprot/W5PP59 ^@ Caution|||Similarity ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM106A ^@ http://purl.uniprot.org/uniprot/A0A836A0T2|||http://purl.uniprot.org/uniprot/W5P5F0 ^@ Caution|||Similarity ^@ Belongs to the TMEM106 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAM72A ^@ http://purl.uniprot.org/uniprot/A0A6P3EJC6|||http://purl.uniprot.org/uniprot/W5P4X7 ^@ Caution|||Similarity ^@ Belongs to the FAM72 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DKK2 ^@ http://purl.uniprot.org/uniprot/W5PGQ6 ^@ Similarity ^@ Belongs to the dickkopf family. http://togogenome.org/gene/9940:CES5A ^@ http://purl.uniprot.org/uniprot/A0A835ZSH4|||http://purl.uniprot.org/uniprot/W5QB42 ^@ Caution|||Similarity ^@ Belongs to the type-B carboxylesterase/lipase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SRXN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E992 ^@ Caution|||Similarity ^@ Belongs to the sulfiredoxin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TBRG4 ^@ http://purl.uniprot.org/uniprot/A0A6P3E460 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DUS4L ^@ http://purl.uniprot.org/uniprot/A0A836D3L8 ^@ Caution|||Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DUSP3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YNT6 ^@ Caution|||Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GRAMD2B ^@ http://purl.uniprot.org/uniprot/A0A836AG87 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SOCS4 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6B0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RAD51C ^@ http://purl.uniprot.org/uniprot/A0A6P3EDV6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GCSH ^@ http://purl.uniprot.org/uniprot/A0A836CV94 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).|||The glycine cleavage system is composed of four proteins: P, T, L and H.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NUP205 ^@ http://purl.uniprot.org/uniprot/W5PH42 ^@ Similarity ^@ Belongs to the NUP186/NUP192/NUP205 family. http://togogenome.org/gene/9940:CPB2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGI2|||http://purl.uniprot.org/uniprot/W5PD62 ^@ Caution|||Similarity ^@ Belongs to the peptidase M14 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DNAJC27 ^@ http://purl.uniprot.org/uniprot/A0A836A8Q9 ^@ Caution|||Function|||Subunit ^@ GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.|||Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ESCO2 ^@ http://purl.uniprot.org/uniprot/W5PZN9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:RAB23 ^@ http://purl.uniprot.org/uniprot/A0A6P7D7U2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GDF5 ^@ http://purl.uniprot.org/uniprot/W5PSD6 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9940:LOC101104213 ^@ http://purl.uniprot.org/uniprot/A0A835ZEW8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101122633 ^@ http://purl.uniprot.org/uniprot/A0A835ZNK7 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ACKR1 ^@ http://purl.uniprot.org/uniprot/W5PCT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.|||Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.|||Early endosome|||Membrane|||Recycling endosome http://togogenome.org/gene/9940:LOC101113195 ^@ http://purl.uniprot.org/uniprot/A0A6P3TGQ8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRPS15 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3S3|||http://purl.uniprot.org/uniprot/W5QEM0 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uS15 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GRM3 ^@ http://purl.uniprot.org/uniprot/W5PZV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.|||Interacts with TAMALIN.|||Membrane http://togogenome.org/gene/9940:CLEC1A ^@ http://purl.uniprot.org/uniprot/A0A6P3ECD1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HLCS ^@ http://purl.uniprot.org/uniprot/W5PXH8 ^@ Similarity ^@ Belongs to the biotin--protein ligase family. http://togogenome.org/gene/9940:LOC443441 ^@ http://purl.uniprot.org/uniprot/Q29422 ^@ Function|||Miscellaneous|||Subcellular Location Annotation|||Subunit ^@ Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.|||Cell membrane|||During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface. Interaction with saposin C is required for the loading of bacterial lipid antigens onto CD1B in the lysosome (By similarity).|||Endosome membrane|||Heterodimer with B2M (beta-2-microglobulin). Interacts with saposin C (By similarity).|||Lysosome membrane http://togogenome.org/gene/9940:MTX2 ^@ http://purl.uniprot.org/uniprot/W5Q7N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9940:ARHGAP26 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9P1 ^@ Caution|||Subcellular Location Annotation ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytoskeleton|||focal adhesion http://togogenome.org/gene/9940:RFXANK ^@ http://purl.uniprot.org/uniprot/A0A6P3EDG0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRKACB ^@ http://purl.uniprot.org/uniprot/W5PWH9|||http://purl.uniprot.org/uniprot/W5PWI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.|||Nucleus http://togogenome.org/gene/9940:ARGLU1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECQ7 ^@ Caution|||Similarity ^@ Belongs to the UPF0430 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KLHL15 ^@ http://purl.uniprot.org/uniprot/A0A6P3EMQ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:DPT ^@ http://purl.uniprot.org/uniprot/A0A6P3EJK4|||http://purl.uniprot.org/uniprot/W5PHI8 ^@ Caution|||Similarity ^@ Belongs to the dermatopontin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LYPLA1 ^@ http://purl.uniprot.org/uniprot/A0A6P3CY59|||http://purl.uniprot.org/uniprot/A0A6P7E7Q5 ^@ Caution|||Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IDNK ^@ http://purl.uniprot.org/uniprot/A0A6P3YJ61 ^@ Caution|||Similarity ^@ Belongs to the gluconokinase GntK/GntV family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HPS3 ^@ http://purl.uniprot.org/uniprot/W5P4Y4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.|||Cytoplasm|||Involved in early stages of melanosome biogenesis and maturation. http://togogenome.org/gene/9940:BBS2 ^@ http://purl.uniprot.org/uniprot/W5QAJ5 ^@ Subcellular Location Annotation ^@ centriolar satellite|||cilium membrane http://togogenome.org/gene/9940:MYO1E ^@ http://purl.uniprot.org/uniprot/A0A6P3E681|||http://purl.uniprot.org/uniprot/W5QI40 ^@ Caution|||Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NOC4L ^@ http://purl.uniprot.org/uniprot/A0A836CV17 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF/MAK21 family.|||Nucleus membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IL1R1 ^@ http://purl.uniprot.org/uniprot/W5PUF0 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9940:TCTN3 ^@ http://purl.uniprot.org/uniprot/W5P952 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/9940:CGRRF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7W2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CNIH1 ^@ http://purl.uniprot.org/uniprot/W5QIU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9940:HTR2B ^@ http://purl.uniprot.org/uniprot/W5QHN7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts (via C-terminus) with MPDZ.|||Membrane|||synaptosome http://togogenome.org/gene/9940:ODR4 ^@ http://purl.uniprot.org/uniprot/W5PBQ8 ^@ Function|||Similarity ^@ Belongs to the ODR-4 family.|||May play a role in the trafficking of a subset of G-protein coupled receptors. http://togogenome.org/gene/9940:TRUB2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8H5|||http://purl.uniprot.org/uniprot/W5PLM8 ^@ Caution|||Similarity ^@ Belongs to the pseudouridine synthase TruB family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RECQL ^@ http://purl.uniprot.org/uniprot/A0A6P3E868|||http://purl.uniprot.org/uniprot/W5QGJ8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TCP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EH93 ^@ Caution|||Similarity ^@ Belongs to the TCP-1 chaperonin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HNF4A ^@ http://purl.uniprot.org/uniprot/F1CGV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9940:CALCA ^@ http://purl.uniprot.org/uniprot/W5P7Y6 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/9940:RPL10L ^@ http://purl.uniprot.org/uniprot/W5NRP9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/9940:BSP5L ^@ http://purl.uniprot.org/uniprot/A0A6P3CX92 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:APH1B ^@ http://purl.uniprot.org/uniprot/A0A6P3TP54|||http://purl.uniprot.org/uniprot/W5QHZ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HTATSF1 ^@ http://purl.uniprot.org/uniprot/W5PNJ4 ^@ Similarity ^@ Belongs to the HTATSF1 family. http://togogenome.org/gene/9940:GPR107 ^@ http://purl.uniprot.org/uniprot/W5PE43 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:LRIF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TSB5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FADS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ED97 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Endoplasmic reticulum membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CACNG2 ^@ http://purl.uniprot.org/uniprot/W5QCC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. http://togogenome.org/gene/9940:SPP1 ^@ http://purl.uniprot.org/uniprot/Q9XSY9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.|||Belongs to the osteopontin family.|||Extensively phosphorylated by FAM20C in the extracellular medium at multiple sites within the S-x-E/pS motif (By similarity). The phosphorylated form inhibits hydroxyapatite crystallization. Dephosphorylation via a mechanism involving ALPL/TNAP promotes hydroxyapatite crystallization (By similarity).|||Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers, increasing its collagen binding properties.|||Ligand for integrin alpha-V/beta-3.|||Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.|||O-glycosylated.|||Secreted http://togogenome.org/gene/9940:AP1S1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YPG2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||clathrin-coated pit http://togogenome.org/gene/9940:NSUN7 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6U7|||http://purl.uniprot.org/uniprot/A0A6P7E958 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:INSR ^@ http://purl.uniprot.org/uniprot/A0A6P3EDM5|||http://purl.uniprot.org/uniprot/W5NQ38 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GNB4 ^@ http://purl.uniprot.org/uniprot/A0A6P3E534|||http://purl.uniprot.org/uniprot/W5QHP5 ^@ Caution|||Similarity ^@ Belongs to the WD repeat G protein beta family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RAB27A ^@ http://purl.uniprot.org/uniprot/C0IZ95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9940:TRMT1L ^@ http://purl.uniprot.org/uniprot/W5P0U7 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||May play a role in motor coordination and exploratory behavior. http://togogenome.org/gene/9940:RTN4 ^@ http://purl.uniprot.org/uniprot/B9VGZ5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9940:MSC ^@ http://purl.uniprot.org/uniprot/A0A6P3E921 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZNF24 ^@ http://purl.uniprot.org/uniprot/W5P6P7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:BMI1 ^@ http://purl.uniprot.org/uniprot/A0A6P7EM60 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FDFT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E118|||http://purl.uniprot.org/uniprot/W5Q0X2 ^@ Caution|||Function|||Similarity ^@ Belongs to the phytoene/squalene synthase family.|||Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RASSF1 ^@ http://purl.uniprot.org/uniprot/C5IJA2 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9940:SH3GLB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6M8|||http://purl.uniprot.org/uniprot/W5PZR0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Golgi apparatus membrane|||Membrane|||Midbody|||Mitochondrion outer membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||autophagosome membrane http://togogenome.org/gene/9940:LOC105613870 ^@ http://purl.uniprot.org/uniprot/W5NTP5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9940:SRSF7 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB34 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PSMD11 ^@ http://purl.uniprot.org/uniprot/A0A6P3YL05 ^@ Caution|||Similarity ^@ Belongs to the proteasome subunit S9 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NMBR ^@ http://purl.uniprot.org/uniprot/A0A836A887|||http://purl.uniprot.org/uniprot/W5NT48 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:REPS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TJK6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCRL2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEN4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCDC117 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHZ3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ORC3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TRK6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC3 family.|||Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.|||Nucleus http://togogenome.org/gene/9940:HIKESHI ^@ http://purl.uniprot.org/uniprot/A0A6P3EJV5|||http://purl.uniprot.org/uniprot/W5P2Q7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.|||Belongs to the OPI10 family.|||Cytoplasm|||Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytosol http://togogenome.org/gene/9940:GMFB ^@ http://purl.uniprot.org/uniprot/W5QIU5 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/9940:MRAS ^@ http://purl.uniprot.org/uniprot/A0A836A1J5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101110727 ^@ http://purl.uniprot.org/uniprot/W5Q9K7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9940:TMED6 ^@ http://purl.uniprot.org/uniprot/W5P042 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9940:PEF1 ^@ http://purl.uniprot.org/uniprot/A0A836ABW7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PAPSS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDP0 ^@ Caution|||Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC13A1 ^@ http://purl.uniprot.org/uniprot/W5NQJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9940:AURKAIP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8R8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UHRF2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E1C3|||http://purl.uniprot.org/uniprot/W5PW10 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LTV1 ^@ http://purl.uniprot.org/uniprot/W5NUC1 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/9940:CDC25B ^@ http://purl.uniprot.org/uniprot/W5NT36 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/9940:IGF1 ^@ http://purl.uniprot.org/uniprot/A0A3S5HYL2|||http://purl.uniprot.org/uniprot/A0A836D4F5|||http://purl.uniprot.org/uniprot/A0FJ28|||http://purl.uniprot.org/uniprot/P10763 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a ternary complex with IGFR1 and ITGA6:ITGB4.|||Secreted|||The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KIT ^@ http://purl.uniprot.org/uniprot/X2BZP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:LOC101110758 ^@ http://purl.uniprot.org/uniprot/A0A6P7D1J1|||http://purl.uniprot.org/uniprot/Q6Q311 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPP2R5A ^@ http://purl.uniprot.org/uniprot/A0A6P3EIC9|||http://purl.uniprot.org/uniprot/W5PM65 ^@ Caution|||Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLPS ^@ http://purl.uniprot.org/uniprot/A0A6P3EJ04|||http://purl.uniprot.org/uniprot/W5PS75 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.|||Enterostatin has a biological activity as a satiety signal.|||Forms a 1:1 stoichiometric complex with pancreatic lipase.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NEUROD6 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBY5|||http://purl.uniprot.org/uniprot/W5PF29 ^@ Caution|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ITIH2 ^@ http://purl.uniprot.org/uniprot/W5PW21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9940:CANX ^@ http://purl.uniprot.org/uniprot/A0A6P3YHQ8|||http://purl.uniprot.org/uniprot/W5NYZ5 ^@ Caution|||Similarity ^@ Belongs to the calreticulin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101102231 ^@ http://purl.uniprot.org/uniprot/W5NTP1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9940:SLCO2A1 ^@ http://purl.uniprot.org/uniprot/Q2VLH9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9940:KCTD9 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7Z2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RESP18 ^@ http://purl.uniprot.org/uniprot/A0A6P3E1S0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NPFFR2 ^@ http://purl.uniprot.org/uniprot/V5JGC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9940:OPRM1 ^@ http://purl.uniprot.org/uniprot/W5P1R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Perikaryon|||axon|||dendrite http://togogenome.org/gene/9940:SNAP47 ^@ http://purl.uniprot.org/uniprot/W5PA99 ^@ Similarity ^@ Belongs to the SVAP1 family. http://togogenome.org/gene/9940:PPP1R3D ^@ http://purl.uniprot.org/uniprot/A0A6P3EIU3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ITPKC ^@ http://purl.uniprot.org/uniprot/W5PAI2 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9940:LOC101122931 ^@ http://purl.uniprot.org/uniprot/W5QB92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:PCBD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YPQ5 ^@ Caution|||Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC25A19 ^@ http://purl.uniprot.org/uniprot/B7U169 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9940:METAP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBF7 ^@ Caution|||Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.|||Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).|||Cytoplasm|||Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM126A ^@ http://purl.uniprot.org/uniprot/A0A6P3EF95|||http://purl.uniprot.org/uniprot/A0A836CSQ4 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPIA ^@ http://purl.uniprot.org/uniprot/K4P1S5 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9940:HMGXB4 ^@ http://purl.uniprot.org/uniprot/A0A836A8I9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GALNT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3T9B5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPL28 ^@ http://purl.uniprot.org/uniprot/W5NTJ6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL28 family. http://togogenome.org/gene/9940:CDKN1A ^@ http://purl.uniprot.org/uniprot/A0A6P3CWX5|||http://purl.uniprot.org/uniprot/A0A6P3TED5 ^@ Caution|||Similarity ^@ Belongs to the CDI family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NPLOC4 ^@ http://purl.uniprot.org/uniprot/A0A6P3YP68 ^@ Caution|||Similarity ^@ Belongs to the NPL4 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IMMP1L ^@ http://purl.uniprot.org/uniprot/A0A6P3T5E2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family.|||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Mitochondrion inner membrane http://togogenome.org/gene/9940:MSL2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E780 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:B4GALT1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQT2|||http://purl.uniprot.org/uniprot/F5CC79 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ACTR2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YGL4 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9940:F13B ^@ http://purl.uniprot.org/uniprot/W5PXX3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:HSF2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8D2|||http://purl.uniprot.org/uniprot/W5PEL6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BAP1 ^@ http://purl.uniprot.org/uniprot/W5P3U3 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/9940:LOC101123247 ^@ http://purl.uniprot.org/uniprot/A0A6P3E684|||http://purl.uniprot.org/uniprot/W5NVV5 ^@ Caution|||Similarity ^@ Belongs to the PI3K p85 subunit family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ASB5 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGW7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101117117 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJB6|||http://purl.uniprot.org/uniprot/A0A6P3TI07 ^@ Caution|||Similarity ^@ Belongs to the heat shock protein 70 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CD93 ^@ http://purl.uniprot.org/uniprot/C5ISB5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:B3GNT7 ^@ http://purl.uniprot.org/uniprot/W5QHQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9940:NXPE3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TV58 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/9940:LCK ^@ http://purl.uniprot.org/uniprot/B7U173 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9940:LOC101111593 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6F9|||http://purl.uniprot.org/uniprot/W5Q0C6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Cell membrane|||Cell surface|||Cytoplasmic vesicle|||Early endosome|||Endoplasmic reticulum|||Endosome|||Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.|||Golgi apparatus|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).|||Nucleus|||Perikaryon|||Secreted|||The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Vesicle|||clathrin-coated pit|||growth cone http://togogenome.org/gene/9940:SNRPD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EL45 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP core protein family.|||Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytosol http://togogenome.org/gene/9940:ARMC9 ^@ http://purl.uniprot.org/uniprot/W5QHP2 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with TOGARAM1, CCDC66, CEP104, CSPP1 and CEP290.|||centriole|||cilium|||cilium basal body http://togogenome.org/gene/9940:OLFML1 ^@ http://purl.uniprot.org/uniprot/W5Q3G8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:LOC101113745 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBX7|||http://purl.uniprot.org/uniprot/W5PN13 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MED21 ^@ http://purl.uniprot.org/uniprot/A0A836D872 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 21 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC1A3 ^@ http://purl.uniprot.org/uniprot/W5PM32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9940:GABRG2 ^@ http://purl.uniprot.org/uniprot/W5PX45 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9940:ACTG1 ^@ http://purl.uniprot.org/uniprot/A0A3R5SS76|||http://purl.uniprot.org/uniprot/A0A6P3EJ42 ^@ Caution|||Similarity ^@ Belongs to the actin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:USP16 ^@ http://purl.uniprot.org/uniprot/A0A6P3TXF5 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. USP16 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Homotetramer.|||Nucleus|||Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.|||Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.|||The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin. http://togogenome.org/gene/9940:NAA20 ^@ http://purl.uniprot.org/uniprot/A0A6P3EK88 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TTI1 ^@ http://purl.uniprot.org/uniprot/A0A836A5X7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CFAP52 ^@ http://purl.uniprot.org/uniprot/W5NYC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP52 family.|||cilium axoneme|||flagellum http://togogenome.org/gene/9940:PRELID3B ^@ http://purl.uniprot.org/uniprot/A0A6P3TJN0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HOXB9 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHB8|||http://purl.uniprot.org/uniprot/W5PA98 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PABPC5 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENF6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101105776 ^@ http://purl.uniprot.org/uniprot/A0A6P3EL19 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GSDMA ^@ http://purl.uniprot.org/uniprot/W5PS33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:PPWD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHA7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101108077 ^@ http://purl.uniprot.org/uniprot/W5Q753 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:C11H17orf98 ^@ http://purl.uniprot.org/uniprot/A0A6P7EIZ6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CMKLR2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TJR2|||http://purl.uniprot.org/uniprot/A0A836D5R6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC6A17 ^@ http://purl.uniprot.org/uniprot/A0A6P3TDR2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GORAB ^@ http://purl.uniprot.org/uniprot/A0A6P3EI05 ^@ Caution|||Similarity ^@ Belongs to the GORAB family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC25A27 ^@ http://purl.uniprot.org/uniprot/J7H8Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9940:RABAC1 ^@ http://purl.uniprot.org/uniprot/C5IJ92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/9940:HEATR1 ^@ http://purl.uniprot.org/uniprot/W5P0K2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HEATR1/UTP10 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/9940:RPL26 ^@ http://purl.uniprot.org/uniprot/A0A6P3ED73|||http://purl.uniprot.org/uniprot/W5QEJ5 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL24 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101102276 ^@ http://purl.uniprot.org/uniprot/W5P6G2 ^@ Subcellular Location Annotation ^@ Nucleus|||kinetochore http://togogenome.org/gene/9940:DIPK2B ^@ http://purl.uniprot.org/uniprot/A0A6P3ESB9|||http://purl.uniprot.org/uniprot/W5P2W5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCDC47 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHM2 ^@ Caution|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Rough endoplasmic reticulum membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZSCAN29 ^@ http://purl.uniprot.org/uniprot/A0A6P3TDI7 ^@ Caution|||Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GLMN ^@ http://purl.uniprot.org/uniprot/A0A6P3TCK0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC5A3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TRS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9940:CFLAR ^@ http://purl.uniprot.org/uniprot/A0A6P3T9A2|||http://purl.uniprot.org/uniprot/A0A6P7DRY0 ^@ Caution|||Similarity ^@ Belongs to the peptidase C14A family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:K33 ^@ http://purl.uniprot.org/uniprot/A0A6P3CXT2|||http://purl.uniprot.org/uniprot/E3VW77 ^@ Caution|||Similarity ^@ Belongs to the intermediate filament family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRMT10C ^@ http://purl.uniprot.org/uniprot/A0A836D7D5 ^@ Caution|||Subcellular Location Annotation ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||mitochondrion nucleoid http://togogenome.org/gene/9940:PPAT ^@ http://purl.uniprot.org/uniprot/A0A6P3TPV6|||http://purl.uniprot.org/uniprot/W5P1C3 ^@ Caution|||Cofactor|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPE65 ^@ http://purl.uniprot.org/uniprot/W5PPC6 ^@ Similarity ^@ Belongs to the carotenoid oxygenase family. http://togogenome.org/gene/9940:ACP5 ^@ http://purl.uniprot.org/uniprot/G3M9U4 ^@ Cofactor ^@ Binds 2 iron ions per subunit. http://togogenome.org/gene/9940:TRAK2 ^@ http://purl.uniprot.org/uniprot/A0A836AE15 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MUTYH ^@ http://purl.uniprot.org/uniprot/W5NTV5 ^@ Cofactor|||Function|||Similarity ^@ Adenine glycosylase active on G-A mispairs.|||Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/9940:RNF40 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGG4|||http://purl.uniprot.org/uniprot/W5PCS0 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101105114 ^@ http://purl.uniprot.org/uniprot/W5NXZ1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9940:RAC1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQI8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:THRB ^@ http://purl.uniprot.org/uniprot/D7RFH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9940:LOC101118574 ^@ http://purl.uniprot.org/uniprot/A0A6P3YS72 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IL20 ^@ http://purl.uniprot.org/uniprot/W5P975 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9940:CLIC5 ^@ http://purl.uniprot.org/uniprot/W5PLA9 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9940:DNAAF1 ^@ http://purl.uniprot.org/uniprot/A0A836A0D3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNAAF1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cilium http://togogenome.org/gene/9940:ATP1B2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EH60|||http://purl.uniprot.org/uniprot/W5Q1B5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9940:UBE2I ^@ http://purl.uniprot.org/uniprot/A0A836CRH5 ^@ Caution|||Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SNRPA ^@ http://purl.uniprot.org/uniprot/B2LYL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM U1 A/B'' family.|||Nucleus http://togogenome.org/gene/9940:CENPH ^@ http://purl.uniprot.org/uniprot/W5P6W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-H/MCM16 family.|||Nucleus|||kinetochore http://togogenome.org/gene/9940:CCSER2 ^@ http://purl.uniprot.org/uniprot/W5NQC7 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/9940:NACA ^@ http://purl.uniprot.org/uniprot/A0A6P3E316 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GIPC2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6K7|||http://purl.uniprot.org/uniprot/W5PV71 ^@ Caution|||Similarity ^@ Belongs to the GIPC family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPL4 ^@ http://purl.uniprot.org/uniprot/A0A836AHP9 ^@ Caution|||Function|||Similarity ^@ Belongs to the universal ribosomal protein uL4 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UBE4A ^@ http://purl.uniprot.org/uniprot/W5PID7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm http://togogenome.org/gene/9940:BLOC1S3 ^@ http://purl.uniprot.org/uniprot/W5PP76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BLOC1S3 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).|||Cytoplasm http://togogenome.org/gene/9940:VTA1 ^@ http://purl.uniprot.org/uniprot/W5NTA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTA1 family.|||Cytoplasm|||Endosome membrane|||Membrane http://togogenome.org/gene/9940:MCM3 ^@ http://purl.uniprot.org/uniprot/W5PXK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9940:PAPOLA ^@ http://purl.uniprot.org/uniprot/W5Q524 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Binds 2 magnesium ions. Also active with manganese.|||Nucleus|||Polymerase that creates the 3'-poly(A) tail of mRNA's. http://togogenome.org/gene/9940:LOC101109184 ^@ http://purl.uniprot.org/uniprot/A0A836ABR8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101117691 ^@ http://purl.uniprot.org/uniprot/P09578 ^@ Domain|||Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. http://togogenome.org/gene/9940:STX7 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6U3|||http://purl.uniprot.org/uniprot/W5PY17 ^@ Caution|||Similarity ^@ Belongs to the syntaxin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAR2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3M5|||http://purl.uniprot.org/uniprot/A0A6P3TLZ1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acyl-CoA reductase family.|||Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.|||Peroxisome membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NUPR1 ^@ http://purl.uniprot.org/uniprot/W5NYZ3 ^@ Similarity ^@ Belongs to the NUPR family. http://togogenome.org/gene/9940:RPE ^@ http://purl.uniprot.org/uniprot/W5QCX4 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/9940:RNPS1 ^@ http://purl.uniprot.org/uniprot/W5Q9J0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the splicing factor SR family.|||Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.|||Nucleus speckle http://togogenome.org/gene/9940:LOC101105186 ^@ http://purl.uniprot.org/uniprot/A0A6P3EH02 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LRRN3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TRB2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HHATL ^@ http://purl.uniprot.org/uniprot/W5P0R1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:LOC101110711 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJI1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9940:NDC80 ^@ http://purl.uniprot.org/uniprot/W5PIP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9940:FXN ^@ http://purl.uniprot.org/uniprot/W5PU52 ^@ Similarity ^@ Belongs to the frataxin family. http://togogenome.org/gene/9940:MPHOSPH10 ^@ http://purl.uniprot.org/uniprot/W5Q385 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPP10 family.|||Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.|||nucleolus http://togogenome.org/gene/9940:BRF2 ^@ http://purl.uniprot.org/uniprot/W5NS82 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/9940:CREG1 ^@ http://purl.uniprot.org/uniprot/A0A836D8C8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CREG family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IGF2BP3 ^@ http://purl.uniprot.org/uniprot/W5PTV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||Nucleus|||P-body|||Stress granule http://togogenome.org/gene/9940:PAG11 ^@ http://purl.uniprot.org/uniprot/A2SZW3 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9940:TMEM263 ^@ http://purl.uniprot.org/uniprot/W5Q8Q0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM263 family.|||Membrane http://togogenome.org/gene/9940:RAB28 ^@ http://purl.uniprot.org/uniprot/A0A6P3CWX0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AVPR1B ^@ http://purl.uniprot.org/uniprot/F6N686 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. http://togogenome.org/gene/9940:LOC101122532 ^@ http://purl.uniprot.org/uniprot/W5P141 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:ENG ^@ http://purl.uniprot.org/uniprot/A0A6P3EAM4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101105208 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGG6|||http://purl.uniprot.org/uniprot/W5PGJ7 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasm|||Inflammasome|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CUL5 ^@ http://purl.uniprot.org/uniprot/W5PMI8 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9940:CISH ^@ http://purl.uniprot.org/uniprot/A0A6P3EEL7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLIN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3CWW8|||http://purl.uniprot.org/uniprot/B0FJL8 ^@ Caution|||Similarity ^@ Belongs to the perilipin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IRAK2 ^@ http://purl.uniprot.org/uniprot/W5P4H5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.|||Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. http://togogenome.org/gene/9940:C3H12orf29 ^@ http://purl.uniprot.org/uniprot/A0A6P3CXU7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:F13A1 ^@ http://purl.uniprot.org/uniprot/W5QAR2 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9940:VTI1A ^@ http://purl.uniprot.org/uniprot/W5PRP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/9940:DPH6 ^@ http://purl.uniprot.org/uniprot/W5QFI8 ^@ Function|||Similarity ^@ Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.|||Belongs to the Diphthine--ammonia ligase family. http://togogenome.org/gene/9940:GALT ^@ http://purl.uniprot.org/uniprot/A0A6P3E0M4 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Binds 1 Fe cation per subunit.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101107550 ^@ http://purl.uniprot.org/uniprot/A0A836A4T8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MTF2 ^@ http://purl.uniprot.org/uniprot/W5Q531 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/9940:CCT7 ^@ http://purl.uniprot.org/uniprot/A0A6P3EA55|||http://purl.uniprot.org/uniprot/W5PQF0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SPTY2D1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFB1|||http://purl.uniprot.org/uniprot/W5PHX5 ^@ Caution|||Similarity ^@ Belongs to the SPT2 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101105495 ^@ http://purl.uniprot.org/uniprot/W5NQU0 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/9940:GSTZ1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6F5|||http://purl.uniprot.org/uniprot/W5NWM7 ^@ Caution|||Similarity ^@ Belongs to the GST superfamily. Zeta family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EXOSC9 ^@ http://purl.uniprot.org/uniprot/A0A836AA96|||http://purl.uniprot.org/uniprot/W5PYP7 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BLZF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB28 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SDAD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E703|||http://purl.uniprot.org/uniprot/W5Q3Y2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDA1 family.|||Required for 60S pre-ribosomal subunits export to the cytoplasm.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:KEF53_p06 ^@ http://purl.uniprot.org/uniprot/O78753|||http://purl.uniprot.org/uniprot/Q5MA70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 3 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM186. Interacts with TMEM242 (By similarity).|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9940:WDR76 ^@ http://purl.uniprot.org/uniprot/A0A6P3TH13 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat DDB2/WDR76 family.|||Interacts with CUL4A and/or CUL4B.|||Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. http://togogenome.org/gene/9940:NFKBIA ^@ http://purl.uniprot.org/uniprot/A0A6P9FQP9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:H1-6 ^@ http://purl.uniprot.org/uniprot/A0A6P3TCF1|||http://purl.uniprot.org/uniprot/W5QFQ9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ITGB1 ^@ http://purl.uniprot.org/uniprot/B0FYY4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Cell surface|||Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis (By similarity). ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (By similarity). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity). Plays an important role in myoblast differentiation and fusion during skeletal myogenesis (By similarity).|||Interacts with seprase FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner (By similarity). Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. ITGA6:ITGB1 is found in a complex with CD9; interaction takes place in oocytes and is involved in sperm-egg fusion. Binds LGALS3BP and NMRK2, when associated with alpha-7, but not with alpha-5. Interacts with FLNA, FLNB, FLNC and RANBP9. Interacts with KRT1 in the presence of RACK1 and SRC. Interacts with JAML; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization. Interacts with RAB21. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region). Interacts with MYO10. Interacts with ITGB1BP1 (via C-terminal region); the interaction is a prerequisite for focal adhesion disassembly. Interacts with TLN1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with ACAP1; required for ITGB1 recycling. Interacts with ASAP3. Interacts with FERMT2; the interaction is inhibited in presence of ITGB1BP1. Interacts with DAB2. Interacts with FGR and HCK. Isoform 2 interacts with alpha-7A and alpha-7B in adult skeletal muscle. Isoform 2 interacts with alpha-7B in cardiomyocytes of adult heart. Interacts with EMP2; the interaction may be direct or indirect and ITGB1 has a heterodimer form (By similarity). ITGA5:ITGB1 interacts with CCN3 (By similarity). ITGA4:ITGB1 is found in a ternary complex with CX3CR1 and CX3CL1 (By similarity). ITGA5:ITGB1 interacts with FBN1 (By similarity). ITGA5:ITGB1 interacts with IL1B. Interacts with MDK. ITGA4:ITGB1 interacts with MDK; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation. ITGA6:ITGB1 interacts with MDK; this interaction mediates MDK-induced neurite-outgrowth (By similarity). ITGA5:ITGB1 interacts with ACE2 (By similarity). Interacts with TMEM182 and LAMB1 (By similarity).|||Melanosome|||Recycling endosome|||The cysteine residues are involved in intrachain disulfide bonds.|||focal adhesion|||invadopodium membrane|||lamellipodium|||ruffle|||ruffle membrane http://togogenome.org/gene/9940:CNPY2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E326|||http://purl.uniprot.org/uniprot/W5PI22 ^@ Caution|||Similarity ^@ Belongs to the canopy family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EXOC5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6B4 ^@ Caution|||Function|||Similarity ^@ Belongs to the SEC10 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DPYSL5 ^@ http://purl.uniprot.org/uniprot/W5QCG2 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9940:LOC101108512 ^@ http://purl.uniprot.org/uniprot/W5P8F0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:LOC101106847 ^@ http://purl.uniprot.org/uniprot/A0A836AFJ6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CASP7 ^@ http://purl.uniprot.org/uniprot/W5PTI1 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9940:SLC26A2 ^@ http://purl.uniprot.org/uniprot/Q9GJY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Cell membrane|||Sulfate transporter. May play a role in endochondral bone formation. http://togogenome.org/gene/9940:PKIB ^@ http://purl.uniprot.org/uniprot/A0A6P3TPS1 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9940:ENO1 ^@ http://purl.uniprot.org/uniprot/W5PIG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9940:PSME2 ^@ http://purl.uniprot.org/uniprot/W5QD41 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/9940:RALA ^@ http://purl.uniprot.org/uniprot/A0A6P3E902 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/9940:INTS2 ^@ http://purl.uniprot.org/uniprot/W5Q1T0 ^@ Similarity ^@ Belongs to the Integrator subunit 2 family. http://togogenome.org/gene/9940:TSHB ^@ http://purl.uniprot.org/uniprot/W5QFW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9940:AGO3 ^@ http://purl.uniprot.org/uniprot/W5QEB1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argonaute family. Ago subfamily.|||Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.|||P-body|||Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. http://togogenome.org/gene/9940:LIG4 ^@ http://purl.uniprot.org/uniprot/A0A6P9FR67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/9940:CCDC174 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENE5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IPPK ^@ http://purl.uniprot.org/uniprot/A0A836D562 ^@ Caution|||Domain|||Function|||Similarity ^@ Belongs to the IPK1 type 2 family.|||Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).|||The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MID1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EMM6|||http://purl.uniprot.org/uniprot/A0A6P3TH99 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytoskeleton http://togogenome.org/gene/9940:PPP2R3C ^@ http://purl.uniprot.org/uniprot/A0A6P3EEA9|||http://purl.uniprot.org/uniprot/W5PBL2 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SH3BGRL3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9B1 ^@ Caution|||Similarity ^@ Belongs to the SH3BGR family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KDELR2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGJ9|||http://purl.uniprot.org/uniprot/W5NVW1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101119226 ^@ http://purl.uniprot.org/uniprot/A0A6P3E739 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PDGFRL ^@ http://purl.uniprot.org/uniprot/W5PHH5 ^@ Subcellular Location Annotation|||Subunit ^@ Forms a complex composed of PDGFRL, TNK2 and GRB2.|||Secreted http://togogenome.org/gene/9940:PRMT2 ^@ http://purl.uniprot.org/uniprot/A0A836AQN4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDK14 ^@ http://purl.uniprot.org/uniprot/A0A6P3YHB8|||http://purl.uniprot.org/uniprot/W5Q4F4 ^@ Caution|||Similarity ^@ Belongs to the protein kinase superfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101115110 ^@ http://purl.uniprot.org/uniprot/W5QGH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9940:SEMA4F ^@ http://purl.uniprot.org/uniprot/W5PTL7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:HMGN3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8B0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IGFBP2 ^@ http://purl.uniprot.org/uniprot/Q29400 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Binds IGF2 more than IGF1.|||Expressed in abundance in selected adult tissues, namely liver, kidney, adrenal, pituitary and choroid plexus.|||Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|||O-glycosylated.|||Secreted|||The C-terminus is required for IGF-binding and growth inhibition. http://togogenome.org/gene/9940:TXNRD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TBU6 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/9940:AP2B1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EI53|||http://purl.uniprot.org/uniprot/A0A6P3THQ3 ^@ Caution|||Similarity ^@ Belongs to the adaptor complexes large subunit family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PSMC6 ^@ http://purl.uniprot.org/uniprot/W5Q805 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9940:ZFP36 ^@ http://purl.uniprot.org/uniprot/A0A836A151|||http://purl.uniprot.org/uniprot/Q6S9E0 ^@ Caution|||Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Associates with cytoplasmic CCR4-NOT and PAN2-PAN3 deadenylase complexes to trigger ARE-containing mRNA deadenylation and decay processes. Part of a mRNA decay activation complex at least composed of poly(A)-specific exoribonucleases CNOT6, EXOSC2 and XRN1 and mRNA-decapping enzymes DCP1A and DCP2. Associates with the RNA exosome complex. Interacts (via phosphorylated form) with 14-3-3 proteins; these interactions promote exclusion of ZFP36 from cytoplasmic stress granules in response to arsenite treatment in a MAPKAPK2-dependent manner and does not prevent CCR4-NOT deadenylase complex recruitment or ZFP36-induced ARE-containing mRNA deadenylation and decay processes. Interacts with 14-3-3 proteins; these interactions occur in response to rapamycin in an Akt-dependent manner. Interacts with AGO2 and AGO4. Interacts (via C-terminus) with CNOT1; this interaction occurs in a RNA-independent manner and induces mRNA deadenylation. Interacts (via N-terminus) with CNOT6. Interacts with CNOT6L. Interacts (via C-terminus) with CNOT7; this interaction occurs in a RNA-independent manner, induces mRNA deadenylation and is inhibited in a phosphorylation MAPKAPK2-dependent manner. Interacts (via unphosphorylated form) with CNOT8; this interaction occurs in a RNA-independent manner and is inhibited in a phosphorylation MAPKAPK2-dependent manner. Interacts with DCP1A. Interacts (via N-terminus) with DCP2. Interacts with EDC3. Interacts (via N-terminus) with EXOSC2. Interacts with heat shock 70 kDa proteins. Interacts with KHSRP; this interaction increases upon cytokine-induced treatment. Interacts with MAP3K4; this interaction enhances the association with SH3KBP1/CIN85. Interacts with MAPKAPK2; this interaction occurs upon skeletal muscle satellite cell activation. Interacts with NCL. Interacts with NUP214; this interaction increases upon lipopolysaccharide (LPS) stimulation. Interacts with PABPC1; this interaction occurs in a RNA-dependent manner. Interacts (via hypophosphorylated form) with PABPN1 (via RRM domain and C-terminal arginine-rich region); this interaction occurs in the nucleus in a RNA-independent manner, decreases in presence of single-stranded poly(A) RNA-oligomer and in a p38 MAPK-dependent-manner and inhibits nuclear poly(A) tail synthesis. Interacts with PAN2. Interacts (via C3H1-type zinc finger domains) with PKM. Interacts (via C3H1-type zinc finger domains) with nuclear RNA poly(A) polymerase. Interacts with PPP2CA; this interaction occurs in LPS-stimulated cells and induces ZFP36 dephosphorylation, and hence may promote ARE-containing mRNAs decay. Interacts (via C-terminus) with PRR5L (via C-terminus); this interaction may accelerate ZFP36-mediated mRNA decay during stress. Interacts (via C-terminus) with SFN; this interaction occurs in a phosphorylation-dependent manner. Interacts (via extreme C-terminal region) with SH3KBP1/CIN85 (via SH3 domains); this interaction enhances MAP3K4-induced phosphorylation of ZFP36 at Ser-64 and Ser-91 and does not alter neither ZFP36 binding to ARE-containing transcripts nor TNF-alpha mRNA decay. Interacts with XRN1. Interacts (via C-terminus and Ser-184 phosphorylated form) with YWHAB; this interaction occurs in a p38/MAPKAPK2-dependent manner, increases cytoplasmic localization of ZFP36 and protects ZFP36 from Ser-184 dephosphorylation by serine/threonine phosphatase 2A, and hence may be crucial for stabilizing ARE-containing mRNAs. Interacts (via phosphorylated form) with YWHAE. Interacts (via C-terminus) with YWHAG; this interaction occurs in a phosphorylation-dependent manner. Interacts with YWHAH; this interaction occurs in a phosphorylation-dependent manner. Interacts with YWHAQ; this interaction occurs in a phosphorylation-dependent manner. Interacts with (via C-terminus) YWHAZ; this interaction occurs in a phosphorylation-dependent manner. Does not interact with SH3KBP1. Interacts (via P-P-P-P-G repeats) with GIGYF2; the interaction is direct (By similarity).|||Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Cytoplasmic granule|||Nucleus|||P-body|||Phosphorylated. Phosphorylation at serine and/or threonine residues occurs in a p38 MAPK- and MAPKAPK2-dependent manner. Phosphorylated by MAPKAPK2 at Ser-58 and Ser-184; phosphorylation increases its stability and cytoplasmic localization, promotes binding to 14-3-3 adapter proteins and inhibits the recruitment of cytoplasmic CCR4-NOT and PAN2-PAN3 deadenylase complexes to the mRNA decay machinery, thereby inhibiting ZFP36-induced ARE-containing mRNA deadenylation and decay processes. Phosphorylation by MAPKAPK2 does not impair ARE-containing RNA-binding. Phosphorylated in a MAPKAPK2- and p38 MAPK-dependent manner upon skeletal muscle satellite cell activation; this phosphorylation inhibits ZFP36-mediated mRNA decay activity, and hence stabilizes MYOD1 mRNA. Phosphorylated by MAPK1 upon mitogen stimulation. Phosphorylated at Ser-64 and Ser-91; these phosphorylations increase in a SH3KBP1-dependent manner. Phosphorylated at serine and threonine residues in a pyruvate kinase PKM- and p38 MAPK-dependent manner. Phosphorylation at Ser-58 may participate in the PKM-mediated degradation of ZFP36 in a p38 MAPK-dependent manner. Dephosphorylated by serine/threonine phosphatase 2A at Ser-184.|||The C3H1-type zinc finger domains are necessary for ARE-binding activity.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Ubiquitinated; pyruvate kinase (PKM)-dependent ubiquitination leads to proteasomal degradation through a p38 MAPK signaling pathway.|||Zinc-finger RNA-binding protein that destabilizes numerous cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation. Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs. Self regulates by destabilizing its own mRNA. Binds to 3'-UTR ARE of numerous mRNAs. Binds also to ARE of its own mRNA. Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages. Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response. Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia. Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA. Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA. Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs. Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs. May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro. Involved in the delivery of target ARE-mRNAs to processing bodies (PBs). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing. Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages. Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion. Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis. Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells.|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/9940:PARN ^@ http://purl.uniprot.org/uniprot/A0A6P3EQP8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMOD3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB32|||http://purl.uniprot.org/uniprot/A0A6P7DVB0 ^@ Caution|||Subcellular Location Annotation ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytoskeleton http://togogenome.org/gene/9940:RPS20 ^@ http://purl.uniprot.org/uniprot/A0A6P3EG90|||http://purl.uniprot.org/uniprot/W5PZT4 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Component of the 40S small ribosomal subunit.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101105553 ^@ http://purl.uniprot.org/uniprot/A0A6P3ESK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RutC family.|||Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.|||Peroxisome http://togogenome.org/gene/9940:SFXN2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YSG6|||http://purl.uniprot.org/uniprot/W5NUR6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TSPAN19 ^@ http://purl.uniprot.org/uniprot/W5Q171 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9940:SLC35B3 ^@ http://purl.uniprot.org/uniprot/W5Q5U3|||http://purl.uniprot.org/uniprot/W5Q5U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9940:DRAM1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E817|||http://purl.uniprot.org/uniprot/W5Q1K2 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMED7 ^@ http://purl.uniprot.org/uniprot/W5Q4H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9940:APEX1 ^@ http://purl.uniprot.org/uniprot/W5QEQ3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/9940:CDCA7 ^@ http://purl.uniprot.org/uniprot/W5NR01 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9940:VSIG1 ^@ http://purl.uniprot.org/uniprot/W5QAU4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:SLC25A30 ^@ http://purl.uniprot.org/uniprot/W5PCL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9940:TIMELESS ^@ http://purl.uniprot.org/uniprot/B3F207 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the timeless family.|||Nucleus http://togogenome.org/gene/9940:DNAJC19 ^@ http://purl.uniprot.org/uniprot/A0A6P3TD92 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101121718 ^@ http://purl.uniprot.org/uniprot/A0A6P3ES39|||http://purl.uniprot.org/uniprot/W5PFW3 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATP6V1H ^@ http://purl.uniprot.org/uniprot/W5PWF2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9940:CARTPT ^@ http://purl.uniprot.org/uniprot/W5P5A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CART family.|||Secreted http://togogenome.org/gene/9940:THOC6 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQM7|||http://purl.uniprot.org/uniprot/W5NS02 ^@ Caution|||Similarity ^@ Belongs to the WD repeat THOC6 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RSL24D1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB30|||http://purl.uniprot.org/uniprot/W5QIC0 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HSPA4 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5W0 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm|||Interacts with TJP1/ZO-1.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ADCK1 ^@ http://purl.uniprot.org/uniprot/W5NXI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Secreted http://togogenome.org/gene/9940:ACTR6 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3F3 ^@ Caution|||Similarity ^@ Belongs to the actin family. ARP6 subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCNB2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB16|||http://purl.uniprot.org/uniprot/W5QI44 ^@ Caution|||Similarity ^@ Belongs to the cyclin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FASLG ^@ http://purl.uniprot.org/uniprot/W5PYV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Cytoplasmic form induces gene transcription inhibition.|||Cytoplasmic vesicle lumen|||Lysosome lumen|||Nucleus|||Secreted http://togogenome.org/gene/9940:TTC19 ^@ http://purl.uniprot.org/uniprot/W5Q7H9 ^@ Similarity ^@ Belongs to the TTC19 family. http://togogenome.org/gene/9940:LOC101106452 ^@ http://purl.uniprot.org/uniprot/W5PTN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p22phox family.|||Cell membrane|||Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).|||Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.|||Membrane http://togogenome.org/gene/9940:ASIP ^@ http://purl.uniprot.org/uniprot/A0A6P3CX05|||http://purl.uniprot.org/uniprot/B4YAJ9 ^@ Caution|||Subcellular Location Annotation ^@ Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLDN8 ^@ http://purl.uniprot.org/uniprot/W5NSC8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9940:DTWD1 ^@ http://purl.uniprot.org/uniprot/A0A836A112 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CFAP97 ^@ http://purl.uniprot.org/uniprot/A0A6P3T6J7 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/9940:PHC2 ^@ http://purl.uniprot.org/uniprot/W5QI39 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:POPDC2 ^@ http://purl.uniprot.org/uniprot/W5QEV1 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9940:PTPN14 ^@ http://purl.uniprot.org/uniprot/W5PGG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/9940:AANAT ^@ http://purl.uniprot.org/uniprot/Q29495 ^@ Function|||Induction|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the acetyltransferase family. AANAT subfamily.|||Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.|||Cytoplasm|||Exhibits night/day variations with a 7-fold increased activity at night. At the mRNA level, the nocturnal increase is lower than 2-fold.|||Highest expression in the pineal gland, followed by retina. Expressed at much lower levels in brainstem and pituitary gland. AANAT activity also detected at low levels in the olfactory lobe.|||Monomer. Interacts with several 14-3-3 proteins, including YWHAB, YWHAE, YWHAG and YWHAZ, preferentially when phosphorylated at Thr-31. Phosphorylation on Ser-205 also allows binding to YWHAZ, but with a 10-fold lower affinity. The interaction with YWHAZ considerably increases affinity for arylalkylamines and acetyl-CoA and protects the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation. The physiological stoichiometry of the interaction is not clear. In vitro studies show either 1:2 (i.e. 1 AANAT molecule per YWHAZ dimer) (PubMed:11427721) or 2:2 (PubMed:11336675).|||cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins. http://togogenome.org/gene/9940:LOC101115733 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB15 ^@ Caution|||Similarity ^@ Belongs to the histone H2B family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EGLN3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBW3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:VPS13C ^@ http://purl.uniprot.org/uniprot/W5QI22 ^@ Similarity ^@ Belongs to the VPS13 family. http://togogenome.org/gene/9940:LZTFL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEN6|||http://purl.uniprot.org/uniprot/W5PIK1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LZTFL1 family.|||Cytoplasm|||Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.|||Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101114408 ^@ http://purl.uniprot.org/uniprot/W5PW57 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9940:HDHD3 ^@ http://purl.uniprot.org/uniprot/A0A836AMB3|||http://purl.uniprot.org/uniprot/W5NY82 ^@ Caution|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLGRKT ^@ http://purl.uniprot.org/uniprot/A0A6P3E9C3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CES4A ^@ http://purl.uniprot.org/uniprot/A0A836A1J8|||http://purl.uniprot.org/uniprot/W5NXC6 ^@ Caution|||Similarity ^@ Belongs to the type-B carboxylesterase/lipase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TPRG1 ^@ http://purl.uniprot.org/uniprot/W5QH01 ^@ Similarity ^@ Belongs to the TPRG1 family. http://togogenome.org/gene/9940:ITGAV ^@ http://purl.uniprot.org/uniprot/B0FYY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9940:H3F3A ^@ http://purl.uniprot.org/uniprot/A0A6P3EHQ7|||http://purl.uniprot.org/uniprot/W5Q8W8 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MEOX1 ^@ http://purl.uniprot.org/uniprot/W5P6W7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:LOC101123441 ^@ http://purl.uniprot.org/uniprot/A0A6P3E1G5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DPYD ^@ http://purl.uniprot.org/uniprot/W5Q7Y9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the dihydropyrimidine dehydrogenase family.|||Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.|||Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. http://togogenome.org/gene/9940:DHX58 ^@ http://purl.uniprot.org/uniprot/W5QAJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9940:LOC101102539 ^@ http://purl.uniprot.org/uniprot/A0A6P3YTL7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NOB1 ^@ http://purl.uniprot.org/uniprot/W5P0A3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOB1 family.|||May play a role in mRNA degradation.|||Nucleus http://togogenome.org/gene/9940:ATP6V1B1 ^@ http://purl.uniprot.org/uniprot/W5PNV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ATPase alpha/beta chains family.|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits. http://togogenome.org/gene/9940:NDFIP2 ^@ http://purl.uniprot.org/uniprot/W5NQH9 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/9940:UCN3 ^@ http://purl.uniprot.org/uniprot/W5P3E3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Binds with high affinity to CRF receptors 2-alpha and 2-beta.|||Secreted|||Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. http://togogenome.org/gene/9940:PIN4 ^@ http://purl.uniprot.org/uniprot/A0A6P3ESI8|||http://purl.uniprot.org/uniprot/W5Q8J0 ^@ Caution|||Similarity ^@ Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101122645 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZG8|||http://purl.uniprot.org/uniprot/W5PUU8 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DSC1 ^@ http://purl.uniprot.org/uniprot/W5P9V7 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/9940:ATP1A1 ^@ http://purl.uniprot.org/uniprot/A0A836D9U0|||http://purl.uniprot.org/uniprot/P04074 ^@ Activity Regulation|||Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Basolateral cell membrane|||Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Melanosome|||Membrane|||Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-941 by PKA modulates the response of ATP1A1 to PKC (By similarity). Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity (By similarity).|||Specifically inhibited by cardiac glycosides such as digoxin or ouabain.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with regulatory subunit FXYD1. Interacts with regulatory subunit FXYD3. Interacts with SIK1. Interacts with SLC35G1 and STIM1. Interacts with CLN3; this interaction regulates the sodium/potassium-transporting ATPase complex localization at the plasma membrane (By similarity).|||This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.|||axon|||sarcolemma http://togogenome.org/gene/9940:OARD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3THU2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BRS3 ^@ http://purl.uniprot.org/uniprot/O97967 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with C6orf89.|||Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). http://togogenome.org/gene/9940:RWDD2A ^@ http://purl.uniprot.org/uniprot/A0A6P3EGN0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TSPAN12 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC22|||http://purl.uniprot.org/uniprot/A0A6P7E0P9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HTRA2 ^@ http://purl.uniprot.org/uniprot/W5PTC7 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/9940:CALHM4 ^@ http://purl.uniprot.org/uniprot/A0A836A1S6|||http://purl.uniprot.org/uniprot/W5PHM3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AIMP2 ^@ http://purl.uniprot.org/uniprot/C5IWT6 ^@ Subcellular Location Annotation ^@ Nucleus|||cytosol http://togogenome.org/gene/9940:PEPD ^@ http://purl.uniprot.org/uniprot/A0A6P3E9Q2|||http://purl.uniprot.org/uniprot/W5P2V3 ^@ Caution|||Similarity ^@ Belongs to the peptidase M24B family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:YIPF5 ^@ http://purl.uniprot.org/uniprot/W5NVS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/9940:FTH1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FNB3|||http://purl.uniprot.org/uniprot/K4PF69 ^@ Caution|||Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC7A7 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7G0|||http://purl.uniprot.org/uniprot/A0A6P3EFM3 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RBM23 ^@ http://purl.uniprot.org/uniprot/A0A6P3TFG8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ACTG2 ^@ http://purl.uniprot.org/uniprot/W5PRA1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9940:LOC101114750 ^@ http://purl.uniprot.org/uniprot/W5P8N0 ^@ Function|||Similarity ^@ Belongs to the CDC26 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. http://togogenome.org/gene/9940:CHCHD4 ^@ http://purl.uniprot.org/uniprot/W5NSY3 ^@ Subcellular Location Annotation ^@ Mitochondrion intermembrane space http://togogenome.org/gene/9940:AVIL ^@ http://purl.uniprot.org/uniprot/A0A6P3E2Z0 ^@ Caution|||Similarity ^@ Belongs to the villin/gelsolin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FZR1 ^@ http://purl.uniprot.org/uniprot/W5PSG6 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/9940:RNF121 ^@ http://purl.uniprot.org/uniprot/A0A6P3ED39|||http://purl.uniprot.org/uniprot/W5NZA6 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SMAD4 ^@ http://purl.uniprot.org/uniprot/A0A6P7DER8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9940:ACTL7A ^@ http://purl.uniprot.org/uniprot/A0A6P3YHC8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||Golgi apparatus|||May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytoskeleton http://togogenome.org/gene/9940:FOLR3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EKR2 ^@ Caution|||Similarity ^@ Belongs to the folate receptor family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARL2BP ^@ http://purl.uniprot.org/uniprot/C5IWU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARL2BP family.|||Cytoplasm|||Mitochondrion intermembrane space|||Nucleus|||Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.|||centrosome|||cilium basal body http://togogenome.org/gene/9940:LOC101116222 ^@ http://purl.uniprot.org/uniprot/W5QAE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:TLR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3CX63|||http://purl.uniprot.org/uniprot/B5DC86 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane|||Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CGGBP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZG4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CNR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFW6|||http://purl.uniprot.org/uniprot/W5QFH2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Signaling typically involves reduction in cyclic AMP.|||Interacts (via C-terminus) with CNRIP1.|||Membrane|||Mitochondrion outer membrane|||Presynapse|||Synapse|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||axon http://togogenome.org/gene/9940:LOC101115664 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDI4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC39A13 ^@ http://purl.uniprot.org/uniprot/C7BDW6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:PDIA3 ^@ http://purl.uniprot.org/uniprot/C6JUQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9940:CNOT9 ^@ http://purl.uniprot.org/uniprot/W5QED0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT9 family.|||P-body http://togogenome.org/gene/9940:ACAD10 ^@ http://purl.uniprot.org/uniprot/W5QBS0 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9940:LOC105603737 ^@ http://purl.uniprot.org/uniprot/W5PSU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9940:NTPCR ^@ http://purl.uniprot.org/uniprot/A0A6P3EM20 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EPYC ^@ http://purl.uniprot.org/uniprot/W5Q2B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.|||extracellular matrix http://togogenome.org/gene/9940:SAR1A ^@ http://purl.uniprot.org/uniprot/W5P7A1 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family.|||Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9940:DDX5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E891 ^@ Caution|||Similarity ^@ Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NUF2 ^@ http://purl.uniprot.org/uniprot/A0A6P3THP9 ^@ Similarity ^@ Belongs to the NUF2 family. http://togogenome.org/gene/9940:C1H1orf162 ^@ http://purl.uniprot.org/uniprot/A0A836AP11 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ABAT ^@ http://purl.uniprot.org/uniprot/W5P5B2 ^@ Similarity|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9940:C5H19orf53 ^@ http://purl.uniprot.org/uniprot/A0A6P3E993|||http://purl.uniprot.org/uniprot/W5PEA8 ^@ Caution|||Function|||Similarity ^@ Belongs to the UPF0390 family.|||May have a potential role in hypercalcemia of malignancy.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CPT1B ^@ http://purl.uniprot.org/uniprot/A0A6P9FN97|||http://purl.uniprot.org/uniprot/Q8SPI7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SEMA3C ^@ http://purl.uniprot.org/uniprot/W5Q605 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9940:LOC101112822 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5Y5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C19H3orf62 ^@ http://purl.uniprot.org/uniprot/A0A835ZPH4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CEPT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3DYP6 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/9940:CALM3 ^@ http://purl.uniprot.org/uniprot/A0A6P7ECH5|||http://purl.uniprot.org/uniprot/Q6YNX6 ^@ Caution|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calmodulin family.|||Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Is a regulator of voltage-dependent L-type calcium channels. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2. Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding. Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2.|||Interacts with CEP97, CCP110, TTN/titin and SRY. Interacts with MYO5A and RRAD (By similarity). Interacts with USP6; the interaction is calcium dependent (By similarity). Interacts with CDK5RAP2. Interacts with SCN5A. Interacts with RYR1 and RYR2 (By similarity). Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure. Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport. Interacts with SYT7 (By similarity). Interacts with MYO10 and MYO1C (By similarity). Interacts with SLC9A1 in a calcium-dependent manner (By similarity). Interacts with HINT1; interaction increases in the presence of calcium ions (By similarity). Interacts with HINT3 (By similarity).|||Phosphorylation results in a decreased activity.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||This protein has four functional calcium-binding sites.|||Ubiquitination results in a strongly decreased activity.|||spindle|||spindle pole http://togogenome.org/gene/9940:MMACHC ^@ http://purl.uniprot.org/uniprot/A0A6P3E680|||http://purl.uniprot.org/uniprot/W5NUC6 ^@ Caution|||Similarity ^@ Belongs to the MMACHC family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NEU1 ^@ http://purl.uniprot.org/uniprot/A0A835ZW35 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 33 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC100144429 ^@ http://purl.uniprot.org/uniprot/Q9XSM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S1 family. Tryptase subfamily.|||Homotetramer.|||Secreted|||Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. http://togogenome.org/gene/9940:GRAP2 ^@ http://purl.uniprot.org/uniprot/W5Q6L9 ^@ Similarity ^@ Belongs to the GRB2/sem-5/DRK family. http://togogenome.org/gene/9940:CWC27 ^@ http://purl.uniprot.org/uniprot/A0A6P3ELM2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAM229B ^@ http://purl.uniprot.org/uniprot/A0A836A7V2|||http://purl.uniprot.org/uniprot/W5PIU3 ^@ Caution|||Similarity ^@ Belongs to the FAM229 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GAB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHN8|||http://purl.uniprot.org/uniprot/W5PMU7|||http://purl.uniprot.org/uniprot/W5PMU8 ^@ Caution|||Similarity ^@ Belongs to the GAB family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TESMIN ^@ http://purl.uniprot.org/uniprot/A0A835ZPP1|||http://purl.uniprot.org/uniprot/W5Q3N0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-54 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HNRNPA2B1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TRD9|||http://purl.uniprot.org/uniprot/W5PK95 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasmic granule|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||extracellular exosome http://togogenome.org/gene/9940:GJA1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6K2|||http://purl.uniprot.org/uniprot/W5QFD5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with SGSM3 (By similarity). Interacts with RIC1/CIP150 (By similarity). Interacts with CNST and CSNK1D (By similarity). Interacts (via C-terminus) with TJP1. Interacts (via C-terminus) with SRC (via SH3 domain). Interacts (not ubiquitinated) with UBQLN4 (via UBA domain) (By similarity). Interacts with NOV. Interacts with TMEM65.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Endoplasmic reticulum|||Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles.|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||gap junction http://togogenome.org/gene/9940:CDKL4 ^@ http://purl.uniprot.org/uniprot/W5PEQ7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9940:PDE6A ^@ http://purl.uniprot.org/uniprot/W5P7F2 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9940:FBN2 ^@ http://purl.uniprot.org/uniprot/W5Q6X0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fibrillin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9940:RAMP3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC07 ^@ Caution|||Similarity ^@ Belongs to the RAMP family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GDF2 ^@ http://purl.uniprot.org/uniprot/W5NSX1 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9940:GHITM ^@ http://purl.uniprot.org/uniprot/A0A6P3ERF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9940:S100A10 ^@ http://purl.uniprot.org/uniprot/A0A6P3YGV7|||http://purl.uniprot.org/uniprot/W5QIU9 ^@ Caution|||Function ^@ Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MYOZ2 ^@ http://purl.uniprot.org/uniprot/E5FXR5 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9940:IL7R ^@ http://purl.uniprot.org/uniprot/A0A836A300|||http://purl.uniprot.org/uniprot/W5PNL9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Membrane|||Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).|||The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101102703 ^@ http://purl.uniprot.org/uniprot/A0A6P3E1W3|||http://purl.uniprot.org/uniprot/W5NXX0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TRSPAP family.|||Cytoplasm|||Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RHCG ^@ http://purl.uniprot.org/uniprot/E5G6E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9940:ZNF605 ^@ http://purl.uniprot.org/uniprot/A0A6P3T1W2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CHIC2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5I6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC105603799 ^@ http://purl.uniprot.org/uniprot/A0A6P3T824 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CHIA ^@ http://purl.uniprot.org/uniprot/W5QE46 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. http://togogenome.org/gene/9940:MARF1 ^@ http://purl.uniprot.org/uniprot/W5PFL4 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9940:HLTF ^@ http://purl.uniprot.org/uniprot/A0A6P3T8D6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AGXT2 ^@ http://purl.uniprot.org/uniprot/W5PPB3 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9940:RETREG3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDJ9|||http://purl.uniprot.org/uniprot/W5NX77 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UPP1 ^@ http://purl.uniprot.org/uniprot/W5Q3H9 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. http://togogenome.org/gene/9940:LOC780772 ^@ http://purl.uniprot.org/uniprot/Q5G2C6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CybS family.|||Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/9940:CCR5 ^@ http://purl.uniprot.org/uniprot/W5PXT0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9940:MED28 ^@ http://purl.uniprot.org/uniprot/W5P035 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 28 family.|||Nucleus http://togogenome.org/gene/9940:ABHD3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDW6|||http://purl.uniprot.org/uniprot/W5PF35 ^@ Caution|||Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TAS2R42 ^@ http://purl.uniprot.org/uniprot/A0A218KHX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9940:PIM1 ^@ http://purl.uniprot.org/uniprot/C0JAN8|||http://purl.uniprot.org/uniprot/C0JAN9 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.|||Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. http://togogenome.org/gene/9940:NPAS4 ^@ http://purl.uniprot.org/uniprot/A0A6P9FRH5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC105601864 ^@ http://purl.uniprot.org/uniprot/W5QFS6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9940:CETN3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEG7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RHOF ^@ http://purl.uniprot.org/uniprot/A0A6P3T1P6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CIAO1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EA98|||http://purl.uniprot.org/uniprot/W5PX14 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the WD repeat CIA1 family.|||Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BAD ^@ http://purl.uniprot.org/uniprot/A0A6P3TF80 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HSPA4L ^@ http://purl.uniprot.org/uniprot/W5Q334 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9940:LOC101114018 ^@ http://purl.uniprot.org/uniprot/A0A6P7EG13|||http://purl.uniprot.org/uniprot/W5PD15 ^@ Caution|||Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/9940:WLS ^@ http://purl.uniprot.org/uniprot/A0A6P3DYE1|||http://purl.uniprot.org/uniprot/W5PP24 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the wntless family.|||Golgi apparatus membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101123341 ^@ http://purl.uniprot.org/uniprot/W5PJ59 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/9940:KDM4C ^@ http://purl.uniprot.org/uniprot/W5PW64 ^@ Similarity ^@ Belongs to the JHDM3 histone demethylase family. http://togogenome.org/gene/9940:LOC101108423 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDX0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMBIM1 ^@ http://purl.uniprot.org/uniprot/A0A6P7DQP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9940:INTS4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQC6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SH2D1B ^@ http://purl.uniprot.org/uniprot/A0A6P3DZW2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NINJ1 ^@ http://purl.uniprot.org/uniprot/W5PE42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ninjurin family.|||Membrane http://togogenome.org/gene/9940:LOC101106806 ^@ http://purl.uniprot.org/uniprot/A0A6P3TCG9 ^@ Function|||Similarity ^@ Belongs to the CMP-Neu5Ac hydroxylase family.|||Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells. http://togogenome.org/gene/9940:KCNE3 ^@ http://purl.uniprot.org/uniprot/A0A6P3T0S6 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9940:MBOAT1 ^@ http://purl.uniprot.org/uniprot/W5PJK8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:RPL3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E411|||http://purl.uniprot.org/uniprot/W5Q4S3 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL3 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OLFML3 ^@ http://purl.uniprot.org/uniprot/W5QFB2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OLFML3 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9940:HOATZ ^@ http://purl.uniprot.org/uniprot/A0A835ZR24|||http://purl.uniprot.org/uniprot/W5PXG7 ^@ Caution|||Similarity ^@ Belongs to the HOATZ family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCT5 ^@ http://purl.uniprot.org/uniprot/A0A6P3ELX6|||http://purl.uniprot.org/uniprot/W5PXX7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FBP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7V5|||http://purl.uniprot.org/uniprot/W5PFR8 ^@ Caution|||Similarity ^@ Belongs to the FBPase class 1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC105613617 ^@ http://purl.uniprot.org/uniprot/W5NR64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:ZKSCAN8 ^@ http://purl.uniprot.org/uniprot/W5Q9D1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:CTSF ^@ http://purl.uniprot.org/uniprot/W5PBB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9940:SARAF ^@ http://purl.uniprot.org/uniprot/W5PKS2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SARAF family.|||Endoplasmic reticulum membrane|||Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.|||Membrane|||Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. http://togogenome.org/gene/9940:ADAMTS20 ^@ http://purl.uniprot.org/uniprot/W5QEN0 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9940:PUS7L ^@ http://purl.uniprot.org/uniprot/W5QEJ8 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/9940:CDK20 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7T4|||http://purl.uniprot.org/uniprot/W5PCQ1 ^@ Caution|||Similarity ^@ Belongs to the protein kinase superfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STEAP2 ^@ http://purl.uniprot.org/uniprot/W5PQR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9940:IK ^@ http://purl.uniprot.org/uniprot/W5QAK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RED family.|||Nucleus http://togogenome.org/gene/9940:SERPINA1 ^@ http://purl.uniprot.org/uniprot/P12725|||http://purl.uniprot.org/uniprot/W5PZS7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the serpin family.|||Inhibits human leukocyte elastase, pig pancreatic elastase and bovine trypsin on a 1:1 molar basis.|||Interacts with CELA2A (By similarity). Interacts with ERGIC3 and LMAN1/ERGIC53 (By similarity). Interacts with PRSS1/Trypsin (By similarity).|||Plasma.|||Secreted|||The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). http://togogenome.org/gene/9940:CSDC2 ^@ http://purl.uniprot.org/uniprot/A0A836D4K2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IL1B ^@ http://purl.uniprot.org/uniprot/P21621 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.|||Lysosome|||Monomer. In its precursor form, weakly interacts with full-length MEFV; the mature cytokine does not interact at all. Interacts with integrins ITGAV:ITGBV and ITGA5:ITGB1; integrin-binding is required for IL1B signaling. Interacts with cargo receptor TMED10; the interaction is direct and is required for the secretion of IL1B mature form. Interacts with HSP90AB1; the interaction facilitates cargo translocation into the ERGIC. Interacts with HSP90B1; the interaction facilitates cargo translocation into the ERGIC.|||Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted|||cytosol|||extracellular exosome http://togogenome.org/gene/9940:CDC14B ^@ http://purl.uniprot.org/uniprot/W5PF48 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/9940:MED1 ^@ http://purl.uniprot.org/uniprot/W5PN52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 1 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9940:WARS1 ^@ http://purl.uniprot.org/uniprot/A0A835ZYM2 ^@ Caution|||Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SERPINA7 ^@ http://purl.uniprot.org/uniprot/P50450 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the serpin family.|||Expressed by the liver and secreted in plasma.|||Major thyroid hormone transport protein in serum.|||Secreted http://togogenome.org/gene/9940:ERAP2 ^@ http://purl.uniprot.org/uniprot/W5Q953 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Membrane http://togogenome.org/gene/9940:SERPINF2 ^@ http://purl.uniprot.org/uniprot/W5PXC8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9940:IFT20 ^@ http://purl.uniprot.org/uniprot/A0A836CZM6|||http://purl.uniprot.org/uniprot/W5Q7W7 ^@ Caution|||Subcellular Location Annotation ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||centriole|||cilium|||cis-Golgi network http://togogenome.org/gene/9940:SREK1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB26 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CSNK1G3 ^@ http://purl.uniprot.org/uniprot/A0A6P7E3W1|||http://purl.uniprot.org/uniprot/W5QBQ4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/9940:SLC25A11 ^@ http://purl.uniprot.org/uniprot/A0A6P9FRD0|||http://purl.uniprot.org/uniprot/B2MVX2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DNAL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E811 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FBLN5 ^@ http://purl.uniprot.org/uniprot/A0A6P3TB39|||http://purl.uniprot.org/uniprot/A0A6P7D2K1 ^@ Caution|||Similarity ^@ Belongs to the fibulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KPNA6 ^@ http://purl.uniprot.org/uniprot/A0A6P3T9P0 ^@ Caution|||Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TOX4 ^@ http://purl.uniprot.org/uniprot/W5QEC6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:HCLS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7W8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101102682 ^@ http://purl.uniprot.org/uniprot/W5PKG9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:KIF5C ^@ http://purl.uniprot.org/uniprot/W5PIF0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9940:DYNC1I2 ^@ http://purl.uniprot.org/uniprot/W5NUY8|||http://purl.uniprot.org/uniprot/W5NUZ1 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/9940:NOP10 ^@ http://purl.uniprot.org/uniprot/W5QF48 ^@ Similarity ^@ Belongs to the NOP10 family. http://togogenome.org/gene/9940:NAF1 ^@ http://purl.uniprot.org/uniprot/W5PW74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAF1 family.|||Nucleus http://togogenome.org/gene/9940:SLC35A4 ^@ http://purl.uniprot.org/uniprot/B2MVY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Membrane http://togogenome.org/gene/9940:MAB21L1 ^@ http://purl.uniprot.org/uniprot/W5P7V1 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9940:MYO1B ^@ http://purl.uniprot.org/uniprot/W5PX99 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9940:DDI2 ^@ http://purl.uniprot.org/uniprot/W5PHE6 ^@ Similarity ^@ Belongs to the DDI1 family. http://togogenome.org/gene/9940:LOC101113761 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7H5|||http://purl.uniprot.org/uniprot/W5PSZ1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:VMA21 ^@ http://purl.uniprot.org/uniprot/A0A6P3EN57|||http://purl.uniprot.org/uniprot/W5PG15 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the V0 complex of the vacuolar ATPase (V-ATPase).|||Belongs to the VMA21 family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101103232 ^@ http://purl.uniprot.org/uniprot/W5Q496 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/9940:SFTPA1 ^@ http://purl.uniprot.org/uniprot/Q9TT06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SFTPA family.|||In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.|||Oligomeric complex of 6 set of homotrimers.|||Secreted|||extracellular matrix|||surface film http://togogenome.org/gene/9940:SLITRK4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EN63 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9940:CLCA2 ^@ http://purl.uniprot.org/uniprot/W5PZ07 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/9940:DPH3 ^@ http://purl.uniprot.org/uniprot/W5Q194 ^@ Similarity ^@ Belongs to the DPH3 family. http://togogenome.org/gene/9940:QARS1 ^@ http://purl.uniprot.org/uniprot/A0A836A002|||http://purl.uniprot.org/uniprot/W5Q0S2 ^@ Caution|||Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BBS4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAR2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BBS4 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||centrosome|||cilium membrane http://togogenome.org/gene/9940:IZUMO2 ^@ http://purl.uniprot.org/uniprot/A0A0M5KTR5 ^@ Similarity ^@ Belongs to the Izumo family. http://togogenome.org/gene/9940:NELFE ^@ http://purl.uniprot.org/uniprot/A0A835ZVB1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM NELF-E family.|||Chromosome|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:COPS4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFB0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN4 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Vesicle|||synaptic vesicle http://togogenome.org/gene/9940:K38 ^@ http://purl.uniprot.org/uniprot/B0LKP2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9940:OTUB2 ^@ http://purl.uniprot.org/uniprot/A0A6P3T2N3 ^@ Caution|||Similarity ^@ Belongs to the peptidase C65 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MCEE ^@ http://purl.uniprot.org/uniprot/W5Q336 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/9940:BCL2L15 ^@ http://purl.uniprot.org/uniprot/A0A6P3DYR4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SBDS ^@ http://purl.uniprot.org/uniprot/A0A6P3EGH3|||http://purl.uniprot.org/uniprot/W5PLQ9 ^@ Caution|||Function|||Similarity ^@ Belongs to the SDO1/SBDS family.|||Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RETN ^@ http://purl.uniprot.org/uniprot/A0A6P3CY62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistin/FIZZ family.|||Secreted http://togogenome.org/gene/9940:HBB ^@ http://purl.uniprot.org/uniprot/Q1KYZ7 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9940:UGT1A6 ^@ http://purl.uniprot.org/uniprot/F1CGW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9940:THEMIS ^@ http://purl.uniprot.org/uniprot/W5PVH7 ^@ Similarity ^@ Belongs to the themis family. http://togogenome.org/gene/9940:PSMD6 ^@ http://purl.uniprot.org/uniprot/W5PNT5 ^@ Similarity ^@ Belongs to the proteasome subunit S10 family. http://togogenome.org/gene/9940:S1PR3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E0J1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FTSJ1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TFP6|||http://purl.uniprot.org/uniprot/A0A6P3THP3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.|||Cytoplasm|||Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CHN2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E447|||http://purl.uniprot.org/uniprot/W5PGJ4 ^@ Caution|||Function ^@ GTPase-activating protein for p21-rac.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZIC5 ^@ http://purl.uniprot.org/uniprot/W5P2P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLI C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9940:LOC101118006 ^@ http://purl.uniprot.org/uniprot/A0A836D430|||http://purl.uniprot.org/uniprot/W5QA06 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SUCNR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TI98|||http://purl.uniprot.org/uniprot/W5P0P6 ^@ Caution|||Similarity ^@ Belongs to the G-protein coupled receptor 1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MSTN ^@ http://purl.uniprot.org/uniprot/A0A0A0YQ60|||http://purl.uniprot.org/uniprot/O18830|||http://purl.uniprot.org/uniprot/Q19BJ5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.|||Secreted|||Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase. http://togogenome.org/gene/9940:UROD ^@ http://purl.uniprot.org/uniprot/A0A836D7U0|||http://purl.uniprot.org/uniprot/Q8HY31 ^@ Caution|||Disease Annotation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway. Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme. In vitro also decarboxylates pentacarboxylate porphyrinogen I.|||Cytoplasm|||Defects in UROD are the cause of porphyria cutanea tarda (PCT). PCT has been identified in a flock of German Blackface sheep. It is characterized by photosensitivity and porphyrinuria.|||Homodimer.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC443326 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9E9|||http://purl.uniprot.org/uniprot/W5PQI1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Endoplasmic reticulum membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SF3B5 ^@ http://purl.uniprot.org/uniprot/W5NX84 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SF3B5 family.|||Component of the spliceosome B complex.|||Nucleus http://togogenome.org/gene/9940:ARF4 ^@ http://purl.uniprot.org/uniprot/C5IWT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9940:OSTN ^@ http://purl.uniprot.org/uniprot/A0A6P3E6V0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SNAI2 ^@ http://purl.uniprot.org/uniprot/A0A6P3CWW7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM35A ^@ http://purl.uniprot.org/uniprot/A0A6P3EHL5|||http://purl.uniprot.org/uniprot/W5NT54 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Endoplasmic reticulum membrane|||Membrane|||Peroxisome membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Vesicle http://togogenome.org/gene/9940:TVP23A ^@ http://purl.uniprot.org/uniprot/A0A6P3EQP3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAS ^@ http://purl.uniprot.org/uniprot/O97491 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane raft http://togogenome.org/gene/9940:PLSCR5 ^@ http://purl.uniprot.org/uniprot/W5P665 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9940:KEF53_p09 ^@ http://purl.uniprot.org/uniprot/O78751|||http://purl.uniprot.org/uniprot/Q5MA73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase protein 8 family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with PRICKLE3 (By similarity).|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion membrane http://togogenome.org/gene/9940:CCR9 ^@ http://purl.uniprot.org/uniprot/Q1WLP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level (By similarity). http://togogenome.org/gene/9940:MT4 ^@ http://purl.uniprot.org/uniprot/A6YLP3 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9940:CCSER1 ^@ http://purl.uniprot.org/uniprot/W5QAE6 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/9940:SCML2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YPP3|||http://purl.uniprot.org/uniprot/W5PW11 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NAA35 ^@ http://purl.uniprot.org/uniprot/A0A6P7DN39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.|||Belongs to the MAK10 family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.|||Cytoplasm http://togogenome.org/gene/9940:TNNI3 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECI8|||http://purl.uniprot.org/uniprot/W5NUQ4 ^@ Caution|||Function|||Similarity ^@ Belongs to the troponin I family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/9940:GGCX ^@ http://purl.uniprot.org/uniprot/Q9GL59 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the vitamin K-dependent gamma-carboxylase family.|||Endoplasmic reticulum membrane|||Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.|||Monomer (By similarity). May interact with CALU (By similarity).|||The vitamin K-dependent protein substrates of carboxylase have usually a propeptide that binds to a high-affinity site on the carboxylase. CO(2), O(2) and reduced vitamin K are cosubstrates. http://togogenome.org/gene/9940:FKBP14 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4Z0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDC42SE1 ^@ http://purl.uniprot.org/uniprot/A0A6P7EJV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.|||Membrane|||Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.|||cytoskeleton http://togogenome.org/gene/9940:LOC101116313 ^@ http://purl.uniprot.org/uniprot/A0A836AG91 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLDN10 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9H3|||http://purl.uniprot.org/uniprot/W5NVE8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||tight junction http://togogenome.org/gene/9940:HOXA6 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4Z6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MYO5A ^@ http://purl.uniprot.org/uniprot/A0A6P3YIX4 ^@ Caution|||Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NUTM1 ^@ http://purl.uniprot.org/uniprot/W5QF46 ^@ Similarity ^@ Belongs to the NUT family. http://togogenome.org/gene/9940:RNF41 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3C3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TPGS2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQE4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRPL22 ^@ http://purl.uniprot.org/uniprot/A0A836A4C7 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL22 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ALAS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EN82|||http://purl.uniprot.org/uniprot/W5P896 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MFSD5 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBH7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Cell membrane|||Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PTGER2 ^@ http://purl.uniprot.org/uniprot/W5Q8C2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9940:WNT2B ^@ http://purl.uniprot.org/uniprot/A0A6P3E5I8|||http://purl.uniprot.org/uniprot/W5QEJ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||extracellular matrix http://togogenome.org/gene/9940:PTX3 ^@ http://purl.uniprot.org/uniprot/A0A836D7N7|||http://purl.uniprot.org/uniprot/W5NXM6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LYVE1 ^@ http://purl.uniprot.org/uniprot/A0A836CVZ7|||http://purl.uniprot.org/uniprot/W5PN42 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NODAL ^@ http://purl.uniprot.org/uniprot/W5P7U5 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9940:CRABP2 ^@ http://purl.uniprot.org/uniprot/W5P895 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm http://togogenome.org/gene/9940:LOC101105866 ^@ http://purl.uniprot.org/uniprot/A0A6P3YS77|||http://purl.uniprot.org/uniprot/W5Q1H2 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101112694 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQU2|||http://purl.uniprot.org/uniprot/W5NY25 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit C family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPUSD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YP87 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NME4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EG59 ^@ Caution|||Similarity ^@ Belongs to the NDK family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:INTS12 ^@ http://purl.uniprot.org/uniprot/A0A6P3TT46 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Integrator subunit 12 family.|||Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.|||Nucleus http://togogenome.org/gene/9940:ZNF664 ^@ http://purl.uniprot.org/uniprot/A0A6P7CZX6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC39A10 ^@ http://purl.uniprot.org/uniprot/W5PY59 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:VPS13B ^@ http://purl.uniprot.org/uniprot/W5NWA2 ^@ Similarity ^@ Belongs to the VPS13 family. http://togogenome.org/gene/9940:BCO1 ^@ http://purl.uniprot.org/uniprot/C7C6F6 ^@ Similarity ^@ Belongs to the carotenoid oxygenase family. http://togogenome.org/gene/9940:CWF19L2 ^@ http://purl.uniprot.org/uniprot/W5PK08 ^@ Similarity ^@ Belongs to the CWF19 family. http://togogenome.org/gene/9940:POU1F1 ^@ http://purl.uniprot.org/uniprot/P79364 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the POU transcription factor family. Class-1 subfamily.|||Interacts with PITX1. Interacts with LHX3. Interacts with ELK1.|||Nucleus|||The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.|||Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'. http://togogenome.org/gene/9940:CCND3 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQE6|||http://purl.uniprot.org/uniprot/B2MVY3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin D subfamily.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLCN6 ^@ http://purl.uniprot.org/uniprot/W5QA97 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9940:LOC101110587 ^@ http://purl.uniprot.org/uniprot/W5PRB2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:CCL22 ^@ http://purl.uniprot.org/uniprot/W5NPF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9940:LOC101107990 ^@ http://purl.uniprot.org/uniprot/W5P8A2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:DOCK10 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6L7|||http://purl.uniprot.org/uniprot/W5QGV5 ^@ Caution|||Similarity ^@ Belongs to the DOCK family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101121639 ^@ http://purl.uniprot.org/uniprot/A0A836D6H0 ^@ Caution|||Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SNU13 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/9940:CCKBR ^@ http://purl.uniprot.org/uniprot/W5QBM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:IL2RA ^@ http://purl.uniprot.org/uniprot/P26898 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Membrane|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit (By similarity).|||Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. http://togogenome.org/gene/9940:P2RX1 ^@ http://purl.uniprot.org/uniprot/W5Q906 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9940:OSBPL11 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4Y9|||http://purl.uniprot.org/uniprot/W5QG92 ^@ Caution|||Similarity ^@ Belongs to the OSBP family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PIGL ^@ http://purl.uniprot.org/uniprot/W5Q6F8 ^@ Function|||Similarity ^@ Belongs to the PIGL family.|||Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol. http://togogenome.org/gene/9940:LOC101119842 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJU9|||http://purl.uniprot.org/uniprot/W5PPC0 ^@ Caution|||Similarity ^@ Belongs to the sulfotransferase 1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AHCYL2 ^@ http://purl.uniprot.org/uniprot/W5P2N4 ^@ Cofactor|||Similarity ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit. http://togogenome.org/gene/9940:LOC101114310 ^@ http://purl.uniprot.org/uniprot/W5Q0L5 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/9940:LOC101117285 ^@ http://purl.uniprot.org/uniprot/W5P7N5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. Thiolase family.|||Cytoplasm|||Interacts with PEX5; the interaction is essential for peroxisomal import.|||Mitochondrion|||Peroxisome http://togogenome.org/gene/9940:SMC1A ^@ http://purl.uniprot.org/uniprot/W5PFJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9940:UBE2R2 ^@ http://purl.uniprot.org/uniprot/W5PHW1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9940:GTF2F1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDP9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF alpha subunit family.|||Nucleus|||TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ASRGL1 ^@ http://purl.uniprot.org/uniprot/A0A835ZXD8 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the Ntn-hydrolase family.|||Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NPPB ^@ http://purl.uniprot.org/uniprot/O46541 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (By similarity). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3 (By similarity).|||Secreted|||The precursor molecule is proteolytically cleaved, possibly by FURIN or CORIN, to produce the active peptide (By similarity). May undergo further proteolytic cleavage by various proteases such as DPP4, MME and possibly FAP, to give rise to a variety of shorter peptides (By similarity). May be cleaved at Pro-99 by the prolyl endopeptidase FAP (seprase) activity (in vitro) (By similarity). May be degraded by IDE (By similarity). During IDE degradation, the resulting products initially increase the activation of NPR1 and can also stimulate NPR2 to produce cGMP before the fragments are completely degraded and inactivated by IDE (in vitro) (By similarity). http://togogenome.org/gene/9940:GADD45G ^@ http://purl.uniprot.org/uniprot/W5PD38 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9940:EIF4E ^@ http://purl.uniprot.org/uniprot/W5Q2Y8 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9940:SPARCL1 ^@ http://purl.uniprot.org/uniprot/W5P4K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPARC family.|||extracellular matrix http://togogenome.org/gene/9940:KRTAP5.4 ^@ http://purl.uniprot.org/uniprot/Q28583 ^@ Function ^@ The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa). http://togogenome.org/gene/9940:KIF1B ^@ http://purl.uniprot.org/uniprot/W5P700 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||axon http://togogenome.org/gene/9940:CTSK ^@ http://purl.uniprot.org/uniprot/W5QI78 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the peptidase C1 family.|||Cell membrane|||Lysosome|||Secreted http://togogenome.org/gene/9940:PIGU ^@ http://purl.uniprot.org/uniprot/W5PK54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGU family.|||Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9940:HSPA5 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAN0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Endoplasmic reticulum lumen|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EMCN ^@ http://purl.uniprot.org/uniprot/A0A6P3E5A8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAM76A ^@ http://purl.uniprot.org/uniprot/A0A836D5Z7|||http://purl.uniprot.org/uniprot/W5NZE4 ^@ Caution|||Similarity ^@ Belongs to the FAM76 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC105601856 ^@ http://purl.uniprot.org/uniprot/A0A836A6L4|||http://purl.uniprot.org/uniprot/W5Q5N7 ^@ Caution|||Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NOC2L ^@ http://purl.uniprot.org/uniprot/A0A6P3TIU6|||http://purl.uniprot.org/uniprot/W5PDH8 ^@ Caution|||Similarity ^@ Belongs to the NOC2 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NEU3 ^@ http://purl.uniprot.org/uniprot/A0A6P3ED51 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 33 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM144 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM144 family.|||Membrane http://togogenome.org/gene/9940:RASSF8 ^@ http://purl.uniprot.org/uniprot/A0A6P3TKB9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC106990414 ^@ http://purl.uniprot.org/uniprot/A0A835ZN36 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101102057 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5L6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101111440 ^@ http://purl.uniprot.org/uniprot/W5Q6G0 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9940:UBAP2L ^@ http://purl.uniprot.org/uniprot/A0A6P3TJ82 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PTGR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TGH3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer or homodimer. http://togogenome.org/gene/9940:PRDX2 ^@ http://purl.uniprot.org/uniprot/A0A6P7E1M0|||http://purl.uniprot.org/uniprot/C8BKC5 ^@ Caution|||Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9940:FAM209A ^@ http://purl.uniprot.org/uniprot/A0A6P3E989 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CYBB ^@ http://purl.uniprot.org/uniprot/A0A6P3ERU7|||http://purl.uniprot.org/uniprot/W5QC99 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OLFML2B ^@ http://purl.uniprot.org/uniprot/W5PLG3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:HADHB ^@ http://purl.uniprot.org/uniprot/A0A6P3E9R6|||http://purl.uniprot.org/uniprot/A0A6P7DVD9 ^@ Caution|||Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRPL30 ^@ http://purl.uniprot.org/uniprot/A0A6P3E2U3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/9940:MED18 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6P5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9940:ATR ^@ http://purl.uniprot.org/uniprot/A0A836AHY6 ^@ Caution|||Similarity ^@ Belongs to the PI3/PI4-kinase family. ATM subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SPRY4 ^@ http://purl.uniprot.org/uniprot/A0A6P7E1U3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:WDFY1 ^@ http://purl.uniprot.org/uniprot/W5QGR5 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9940:TCTA ^@ http://purl.uniprot.org/uniprot/A0A6P3ECB3|||http://purl.uniprot.org/uniprot/W5PWG0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCTA family.|||May be required for cellular fusion during osteoclastogenesis.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BMP15 ^@ http://purl.uniprot.org/uniprot/A0A0S1TT01|||http://purl.uniprot.org/uniprot/A0A835ZFN4|||http://purl.uniprot.org/uniprot/Q9MZE2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer (By similarity). But, in contrast to other members of this family, cannot be disulfide-linked.|||May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PTGR2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFF2|||http://purl.uniprot.org/uniprot/W5NRG0 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TEKT5 ^@ http://purl.uniprot.org/uniprot/A0A6P3ERG0|||http://purl.uniprot.org/uniprot/W5P758 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||flagellum http://togogenome.org/gene/9940:SEC23A ^@ http://purl.uniprot.org/uniprot/A0A6P3EEB1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytosol http://togogenome.org/gene/9940:LOC101108086 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJI1|||http://purl.uniprot.org/uniprot/A0A836CTR2 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CYP19 ^@ http://purl.uniprot.org/uniprot/Q9XS28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Catalyzes the formation of aromatic C18 estrogens from C19 androgens.|||Membrane http://togogenome.org/gene/9940:TNPO1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDL1 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MBD4 ^@ http://purl.uniprot.org/uniprot/W5PZ82 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with MLH1.|||Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.|||Nucleus http://togogenome.org/gene/9940:CENPK ^@ http://purl.uniprot.org/uniprot/A0A6P3EN89|||http://purl.uniprot.org/uniprot/A0A6P3YN62 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-K/MCM22 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||centromere http://togogenome.org/gene/9940:MGME1 ^@ http://purl.uniprot.org/uniprot/A0A836CWE3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HSPB11 ^@ http://purl.uniprot.org/uniprot/A0A6P3E402 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101108746 ^@ http://purl.uniprot.org/uniprot/W5Q5R1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:STAMBPL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EPW9|||http://purl.uniprot.org/uniprot/A0A6P3TIQ4 ^@ Caution|||Similarity ^@ Belongs to the peptidase M67C family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NUDT2 ^@ http://purl.uniprot.org/uniprot/A0A836ALY5|||http://purl.uniprot.org/uniprot/W5PHQ4 ^@ Caution|||Similarity ^@ Belongs to the Nudix hydrolase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MINDY3 ^@ http://purl.uniprot.org/uniprot/W5PG92 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/9940:UMOD ^@ http://purl.uniprot.org/uniprot/W5PSM9 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Cell membrane|||In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||cilium membrane http://togogenome.org/gene/9940:SLC7A9 ^@ http://purl.uniprot.org/uniprot/A0A6P3EL78|||http://purl.uniprot.org/uniprot/A0A6P7EVW1 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HCAR2 ^@ http://purl.uniprot.org/uniprot/W5P3D9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9940:TMEM156 ^@ http://purl.uniprot.org/uniprot/A0A836D0Q1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:WFIKKN2 ^@ http://purl.uniprot.org/uniprot/W5NZ88 ^@ Similarity ^@ Belongs to the WFIKKN family. http://togogenome.org/gene/9940:COPS7A ^@ http://purl.uniprot.org/uniprot/A0A6P3TKJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9940:PDE1A ^@ http://purl.uniprot.org/uniprot/W5Q5R0 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9940:AQP9 ^@ http://purl.uniprot.org/uniprot/A0A6P3EF22|||http://purl.uniprot.org/uniprot/W5QI67 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRIM4 ^@ http://purl.uniprot.org/uniprot/A0A6P3ELX8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101109747 ^@ http://purl.uniprot.org/uniprot/A0A6P3T7R2|||http://purl.uniprot.org/uniprot/B8ZY39 ^@ Caution|||Similarity ^@ Belongs to the MHC class II family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ME2 ^@ http://purl.uniprot.org/uniprot/W5P368 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/9940:LOC101110385 ^@ http://purl.uniprot.org/uniprot/W5PXQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGP family.|||Membrane|||Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. http://togogenome.org/gene/9940:ERBIN ^@ http://purl.uniprot.org/uniprot/A0A836CVI0|||http://purl.uniprot.org/uniprot/W5P7P9 ^@ Caution|||Similarity ^@ Belongs to the LAP (LRR and PDZ) protein family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GJB5 ^@ http://purl.uniprot.org/uniprot/W5NQF5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||gap junction http://togogenome.org/gene/9940:LY6G6C ^@ http://purl.uniprot.org/uniprot/A0A6P3ECQ3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GTPBP3 ^@ http://purl.uniprot.org/uniprot/W5Q668 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. http://togogenome.org/gene/9940:HTR1D ^@ http://purl.uniprot.org/uniprot/W5QAN1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Homodimer. Heterodimer with HTR1B.|||Membrane http://togogenome.org/gene/9940:IDH3B ^@ http://purl.uniprot.org/uniprot/W5P8N8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/9940:RAB11A ^@ http://purl.uniprot.org/uniprot/A0A6P3E779 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101108337 ^@ http://purl.uniprot.org/uniprot/W5Q762 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:LOC654403 ^@ http://purl.uniprot.org/uniprot/A0A6P3E708|||http://purl.uniprot.org/uniprot/W5QHK1 ^@ Caution|||Similarity ^@ Belongs to the arrestin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MTIF2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E2M6 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/9940:NIFK ^@ http://purl.uniprot.org/uniprot/A0A6P3YHV2|||http://purl.uniprot.org/uniprot/W5PV04 ^@ Caution|||Subcellular Location Annotation ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:SERPINB1 ^@ http://purl.uniprot.org/uniprot/D8X187 ^@ Similarity ^@ Belongs to the serpin family. Ov-serpin subfamily. http://togogenome.org/gene/9940:SLC25A26 ^@ http://purl.uniprot.org/uniprot/B2MVX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9940:KLHL41 ^@ http://purl.uniprot.org/uniprot/A0A836D6Y7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:COPB2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8E1|||http://purl.uniprot.org/uniprot/W5PAX6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat COPB2 family.|||COPI-coated vesicle membrane|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner. http://togogenome.org/gene/9940:LOC101121908 ^@ http://purl.uniprot.org/uniprot/W5NQE7 ^@ Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. http://togogenome.org/gene/9940:CYP11A1 ^@ http://purl.uniprot.org/uniprot/P79202 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones (By similarity). Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (By similarity).|||Belongs to the cytochrome P450 family.|||Interacts with FDX1/adrenodoxin.|||Mitochondrion inner membrane http://togogenome.org/gene/9940:APH1A ^@ http://purl.uniprot.org/uniprot/A0A6P3E5Q3|||http://purl.uniprot.org/uniprot/W5QHY7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TAF7L ^@ http://purl.uniprot.org/uniprot/W5NTU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus http://togogenome.org/gene/9940:LOC101112513 ^@ http://purl.uniprot.org/uniprot/A0A835ZTL8|||http://purl.uniprot.org/uniprot/W5PR30 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CYP17A1 ^@ http://purl.uniprot.org/uniprot/Q29497 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).|||Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||Microsome membrane|||Regulated predominantly by intracellular cAMP levels. The 17,20-lyase activity is stimulated by cytochrome b5, which acts as an allosteric effector increasing the Vmax of the lyase activity. http://togogenome.org/gene/9940:CPO ^@ http://purl.uniprot.org/uniprot/W5QBY3 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9940:SLC25A29 ^@ http://purl.uniprot.org/uniprot/W5NUR9|||http://purl.uniprot.org/uniprot/W5NUS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9940:HDC ^@ http://purl.uniprot.org/uniprot/W5QIK7 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9940:AK1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQJ4|||http://purl.uniprot.org/uniprot/C5IJA8 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK1 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRPM7 ^@ http://purl.uniprot.org/uniprot/A4ZVC4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.|||Membrane http://togogenome.org/gene/9940:PLK2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB43|||http://purl.uniprot.org/uniprot/W5PBE3 ^@ Caution|||Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATP6V0A4 ^@ http://purl.uniprot.org/uniprot/W5PLB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/9940:NDUFB7 ^@ http://purl.uniprot.org/uniprot/A0A8N7XJH2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB7 subunit family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PAX6 ^@ http://purl.uniprot.org/uniprot/W5Q3U7|||http://purl.uniprot.org/uniprot/W5Q3U9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9940:BAZ2A ^@ http://purl.uniprot.org/uniprot/A0A6P3E3B4 ^@ Caution|||Similarity ^@ Belongs to the WAL family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM154 ^@ http://purl.uniprot.org/uniprot/A0A6P9FR30 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CATHL3 ^@ http://purl.uniprot.org/uniprot/P50415 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms (By similarity).|||Secreted http://togogenome.org/gene/9940:NGB ^@ http://purl.uniprot.org/uniprot/A0A6P3EFG7|||http://purl.uniprot.org/uniprot/W5NWE8 ^@ Caution|||Similarity ^@ Belongs to the globin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101103669 ^@ http://purl.uniprot.org/uniprot/W5PBH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:FANCM ^@ http://purl.uniprot.org/uniprot/W5PI59 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. http://togogenome.org/gene/9940:POLR2I ^@ http://purl.uniprot.org/uniprot/A0A6P3EFK6|||http://purl.uniprot.org/uniprot/W5P5E8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:CLDN15 ^@ http://purl.uniprot.org/uniprot/A0A6P3T9Z0|||http://purl.uniprot.org/uniprot/A0A6P3TJV1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||tight junction http://togogenome.org/gene/9940:ABRAXAS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YM19 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM175 family. Abraxas subfamily.|||Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PSMB8 ^@ http://purl.uniprot.org/uniprot/B3VSB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9940:PDCD5 ^@ http://purl.uniprot.org/uniprot/W5P225 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/9940:MAP4 ^@ http://purl.uniprot.org/uniprot/W5NXB5 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9940:DNTTIP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EF48|||http://purl.uniprot.org/uniprot/W5P8P6 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MILR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAJ2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ETS2 ^@ http://purl.uniprot.org/uniprot/W5PYQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9940:GLIS3 ^@ http://purl.uniprot.org/uniprot/W5PV59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLI C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9940:MLANA ^@ http://purl.uniprot.org/uniprot/A0A6P3YG15 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101107496 ^@ http://purl.uniprot.org/uniprot/A0A6P3YII5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101114419 ^@ http://purl.uniprot.org/uniprot/A0A6P3T6Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPIN/STSY family.|||Nucleus http://togogenome.org/gene/9940:CCT6B ^@ http://purl.uniprot.org/uniprot/W5PFI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9940:LOC106990148 ^@ http://purl.uniprot.org/uniprot/W5P1T3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9940:MFAP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEC0|||http://purl.uniprot.org/uniprot/W5PNL1 ^@ Caution|||Function|||Similarity ^@ Belongs to the MFAP1 family.|||Involved in pre-mRNA splicing as a component of the spliceosome.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ADAT2 ^@ http://purl.uniprot.org/uniprot/W5NTV4 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.|||Probably participates in deamination of adenosine-34 to inosine in many tRNAs. http://togogenome.org/gene/9940:DHRS7C ^@ http://purl.uniprot.org/uniprot/W5NZC0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9940:PARP14 ^@ http://purl.uniprot.org/uniprot/W5QG00 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9940:ST3GAL3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YGJ2|||http://purl.uniprot.org/uniprot/W5NQT4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DDX21 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQV3|||http://purl.uniprot.org/uniprot/W5P5J5 ^@ Caution|||Similarity ^@ Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LIPE ^@ http://purl.uniprot.org/uniprot/B3EYB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 'GDXG' lipolytic enzyme family.|||Cell membrane|||Lipid droplet|||caveola|||cytosol http://togogenome.org/gene/9940:LOC101122647 ^@ http://purl.uniprot.org/uniprot/A0A6P3TIU7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TAB3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YQ43 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCNYL1 ^@ http://purl.uniprot.org/uniprot/W5QC45 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/9940:LPAR6 ^@ http://purl.uniprot.org/uniprot/S4TZP1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9940:LOC101121351 ^@ http://purl.uniprot.org/uniprot/A0A836AEA7|||http://purl.uniprot.org/uniprot/W5NRF1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ELOVL3 ^@ http://purl.uniprot.org/uniprot/W5Q848 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL3 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-Glycosylated.|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9940:EIF5A ^@ http://purl.uniprot.org/uniprot/A0A6P3TWD0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Membrane|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.|||mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. http://togogenome.org/gene/9940:GNS ^@ http://purl.uniprot.org/uniprot/W5NZ62 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Lysosome|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9940:SIAH1 ^@ http://purl.uniprot.org/uniprot/W5Q641 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9940:TM4SF18 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8C5|||http://purl.uniprot.org/uniprot/W5P4A7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CSNK2B ^@ http://purl.uniprot.org/uniprot/B7U170 ^@ Function|||Similarity|||Subunit ^@ Belongs to the casein kinase 2 subunit beta family.|||Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/9940:SDE2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHY7|||http://purl.uniprot.org/uniprot/W5Q8U6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDE2 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PIAS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YMH9 ^@ Caution|||Similarity ^@ Belongs to the PIAS family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101123223 ^@ http://purl.uniprot.org/uniprot/A0A6P3EIE1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GUCA1B ^@ http://purl.uniprot.org/uniprot/A0A835ZSL7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CREB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EA07|||http://purl.uniprot.org/uniprot/W5QBZ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:TCEAL1 ^@ http://purl.uniprot.org/uniprot/W5PJP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family. TFA subfamily.|||Nucleus http://togogenome.org/gene/9940:STK32B ^@ http://purl.uniprot.org/uniprot/W5PB90 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9940:RAB5A ^@ http://purl.uniprot.org/uniprot/A0A6P3YEQ4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRP2 ^@ http://purl.uniprot.org/uniprot/A8QW38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/9940:ABHD14A ^@ http://purl.uniprot.org/uniprot/A0A6P3EN85 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GLT1D1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDX9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101104781 ^@ http://purl.uniprot.org/uniprot/A0A836CV55 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AMH ^@ http://purl.uniprot.org/uniprot/T1SHH2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation and plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression.|||Secreted http://togogenome.org/gene/9940:TAFAZZIN ^@ http://purl.uniprot.org/uniprot/A0A6P3EN53|||http://purl.uniprot.org/uniprot/W5P447 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.|||Associates with multiple protein complexes.|||Belongs to the taffazin family.|||Mitochondrion inner membrane|||Mitochondrion outer membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101122880 ^@ http://purl.uniprot.org/uniprot/A0A6P3EL04|||http://purl.uniprot.org/uniprot/W5QCB7 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EPO ^@ http://purl.uniprot.org/uniprot/P33709 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the EPO/TPO family.|||Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.|||Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.|||Secreted http://togogenome.org/gene/9940:CTSB ^@ http://purl.uniprot.org/uniprot/P83205 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the peptidase C1 family.|||Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Directly interacts with SHKBP1.|||Lysosome|||Melanosome|||Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity).|||extracellular space http://togogenome.org/gene/9940:LOC101102694 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3R3|||http://purl.uniprot.org/uniprot/W5Q9L6 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9940:RDH12 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBC3 ^@ Caution|||Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101121084 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3Q2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ANAPC11 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8A5|||http://purl.uniprot.org/uniprot/A0A6P7EFS1 ^@ Caution|||Similarity ^@ Belongs to the RING-box family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DIRAS3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TFY0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CSTF2T ^@ http://purl.uniprot.org/uniprot/W5QCU3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:MXD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAU2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101120814 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHQ6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CHRNA2 ^@ http://purl.uniprot.org/uniprot/W5PIW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9940:CALY ^@ http://purl.uniprot.org/uniprot/W5NRQ2 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/9940:ASF1A ^@ http://purl.uniprot.org/uniprot/C8BKD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/9940:GTPBP4 ^@ http://purl.uniprot.org/uniprot/A0A836A3P4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.|||Involved in the biogenesis of the 60S ribosomal subunit.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:RHO ^@ http://purl.uniprot.org/uniprot/W5PXZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/9940:GPR160 ^@ http://purl.uniprot.org/uniprot/A0A6P3T2W0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IMPDH2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EIU2|||http://purl.uniprot.org/uniprot/W5Q1I6 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EARS2 ^@ http://purl.uniprot.org/uniprot/W5Q6N0 ^@ Function|||Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). http://togogenome.org/gene/9940:FLOT1 ^@ http://purl.uniprot.org/uniprot/A0A836CTM6 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Cell membrane|||Endosome|||Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||caveola http://togogenome.org/gene/9940:PHAF1 ^@ http://purl.uniprot.org/uniprot/A0A836A0Q6|||http://purl.uniprot.org/uniprot/W5NXG6 ^@ Caution|||Similarity ^@ Belongs to the PHAF1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:COPS7B ^@ http://purl.uniprot.org/uniprot/A0A6P7DLN1|||http://purl.uniprot.org/uniprot/C5ISA4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:VPS26C ^@ http://purl.uniprot.org/uniprot/A0A6P3E5D1|||http://purl.uniprot.org/uniprot/W5PY43 ^@ Caution|||Similarity ^@ Belongs to the VPS26 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SERPINC1 ^@ http://purl.uniprot.org/uniprot/P32262 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the serpin family.|||Forms protease inhibiting heterodimer with TMPRSS7.|||Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity).|||Phosphorylated by FAM20C in the extracellular medium.|||Plasma.|||extracellular space http://togogenome.org/gene/9940:RGS8 ^@ http://purl.uniprot.org/uniprot/A0A6P7EKT9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Nucleus|||Perikaryon|||dendrite http://togogenome.org/gene/9940:ADRM1 ^@ http://purl.uniprot.org/uniprot/W5PXE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADRM1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9940:MCUB ^@ http://purl.uniprot.org/uniprot/A0A6P3EDM3|||http://purl.uniprot.org/uniprot/W5P7S5 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCU (TC 1.A.77) family.|||Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).|||Membrane|||Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RTN4IP1 ^@ http://purl.uniprot.org/uniprot/W5PNA6 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9940:MBNL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TI85 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DHDDS ^@ http://purl.uniprot.org/uniprot/W5P315 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/9940:POF1B ^@ http://purl.uniprot.org/uniprot/A0A835ZN88 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GAPVD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TAB9|||http://purl.uniprot.org/uniprot/W5PTE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAPVD1 family.|||Membrane http://togogenome.org/gene/9940:HPD ^@ http://purl.uniprot.org/uniprot/A0A6P3EBH2|||http://purl.uniprot.org/uniprot/W5PSL9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 4HPPD family.|||Binds 1 Fe cation per subunit.|||Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:THPO ^@ http://purl.uniprot.org/uniprot/W5QHB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EPO/TPO family.|||Secreted http://togogenome.org/gene/9940:ACMSD ^@ http://purl.uniprot.org/uniprot/W5PNY8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.|||Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.|||Monomer. http://togogenome.org/gene/9940:SMG1 ^@ http://purl.uniprot.org/uniprot/W5PMR0 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. http://togogenome.org/gene/9940:CSTF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEY4|||http://purl.uniprot.org/uniprot/W5QAA0 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC25A25 ^@ http://purl.uniprot.org/uniprot/W5PMS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9940:HYAL3 ^@ http://purl.uniprot.org/uniprot/W5PJ30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 56 family.|||Cell membrane|||Early endosome|||Endoplasmic reticulum|||Endosome|||Membrane|||acrosome http://togogenome.org/gene/9940:LOC101109935 ^@ http://purl.uniprot.org/uniprot/A0A836CTN2|||http://purl.uniprot.org/uniprot/W5PD13 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NTMT2 ^@ http://purl.uniprot.org/uniprot/A0A836CYF4 ^@ Caution|||Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GALM ^@ http://purl.uniprot.org/uniprot/A0A6P3E2P2|||http://purl.uniprot.org/uniprot/W5PGC5 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the aldose epimerase family.|||Monomer.|||Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ANXA9 ^@ http://purl.uniprot.org/uniprot/A0A6P3TFC2|||http://purl.uniprot.org/uniprot/A0A6P7EJP0 ^@ Caution|||Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NFYA ^@ http://purl.uniprot.org/uniprot/A0A6P3EPR5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AZU1 ^@ http://purl.uniprot.org/uniprot/A0A836D5N0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLCA1 ^@ http://purl.uniprot.org/uniprot/W5PZ44 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/9940:RAF1 ^@ http://purl.uniprot.org/uniprot/W5Q234 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/9940:TM7SF3 ^@ http://purl.uniprot.org/uniprot/W5QEZ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:FMO5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6Z5|||http://purl.uniprot.org/uniprot/A0A6P3TMZ8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRKCE ^@ http://purl.uniprot.org/uniprot/A0A6P3E2N3 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.|||Cell membrane|||Cytoplasm|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytoskeleton|||perinuclear region http://togogenome.org/gene/9940:CORO1A ^@ http://purl.uniprot.org/uniprot/A0A6P3TEE0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat coronin family.|||Binds actin.|||Membrane|||cell cortex|||cytoskeleton|||phagosome membrane http://togogenome.org/gene/9940:CDC37L1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9B6|||http://purl.uniprot.org/uniprot/W5PVC2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101113369 ^@ http://purl.uniprot.org/uniprot/A0A836CVN3|||http://purl.uniprot.org/uniprot/W5QGB5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RAB27B ^@ http://purl.uniprot.org/uniprot/W5P4F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9940:FGG ^@ http://purl.uniprot.org/uniprot/W5Q5A6 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/9940:NAA40 ^@ http://purl.uniprot.org/uniprot/W5P1I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA40 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9940:CREBL2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB82 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HMGCS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3T5V7 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/9940:LOC101118521 ^@ http://purl.uniprot.org/uniprot/W5QAI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:LOC100240716 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQJ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SKP1 family.|||Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.|||Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.|||The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. http://togogenome.org/gene/9940:DDX10 ^@ http://purl.uniprot.org/uniprot/A0A6P3EA57 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POLR3C ^@ http://purl.uniprot.org/uniprot/A0A6P3E5N7|||http://purl.uniprot.org/uniprot/W5QHC5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NDUFB6 ^@ http://purl.uniprot.org/uniprot/D6QZ20 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB6 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9940:PTPN2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YSQ3 ^@ Caution|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EIF3K ^@ http://purl.uniprot.org/uniprot/A0A6P3EFM4|||http://purl.uniprot.org/uniprot/W5P6X4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit K family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AGL ^@ http://purl.uniprot.org/uniprot/A0A6P3TG45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycogen debranching enzyme family.|||Cytoplasm|||Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. http://togogenome.org/gene/9940:PRKAB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3T1Z5|||http://purl.uniprot.org/uniprot/A0A6P3TAG1 ^@ Caution|||Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDC37 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4I2|||http://purl.uniprot.org/uniprot/W5Q3Q7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GDI1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FRE2|||http://purl.uniprot.org/uniprot/C5IJ94 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HNF1B ^@ http://purl.uniprot.org/uniprot/W5NZG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HNF1 homeobox family.|||Nucleus http://togogenome.org/gene/9940:CSN3 ^@ http://purl.uniprot.org/uniprot/A0A059T9N6|||http://purl.uniprot.org/uniprot/P02669 ^@ Function|||PTM|||Polymorphism|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the kappa-casein family.|||Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.|||Mammary gland specific. Secreted in milk.|||O-glycosylated on Thr at position 156, 158 or 159.|||Secreted|||The frequency of variant Leu-125 is 0.015 in the Italian breed Sopravissana. http://togogenome.org/gene/9940:LHX5 ^@ http://purl.uniprot.org/uniprot/W5PAX7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:LOC101115671 ^@ http://purl.uniprot.org/uniprot/W5P0T3 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9940:RPL18 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFU1|||http://purl.uniprot.org/uniprot/W5PQR5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL18 family.|||Rough endoplasmic reticulum|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ACER1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECM2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ETFA ^@ http://purl.uniprot.org/uniprot/A0A6P3EMP3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EIF1B ^@ http://purl.uniprot.org/uniprot/W5NX86 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/9940:TMEM223 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDA5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AACS ^@ http://purl.uniprot.org/uniprot/A0A6P3EM53|||http://purl.uniprot.org/uniprot/W5Q7T6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Converts acetoacetate to acetoacetyl-CoA in the cytosol.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytosol http://togogenome.org/gene/9940:ZDHHC21 ^@ http://purl.uniprot.org/uniprot/A0A6P3TGZ9 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9940:THEM6 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC50 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101115849 ^@ http://purl.uniprot.org/uniprot/G9HPB5|||http://purl.uniprot.org/uniprot/G9HPB6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9940:COQ2 ^@ http://purl.uniprot.org/uniprot/W5NW46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.|||Mitochondrion inner membrane http://togogenome.org/gene/9940:LOC101106121 ^@ http://purl.uniprot.org/uniprot/A0A6P3E695 ^@ Caution|||Similarity ^@ Belongs to the cytochrome P450 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RNMT ^@ http://purl.uniprot.org/uniprot/A0A6P7EZF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.|||In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.|||Nucleus http://togogenome.org/gene/9940:LRRC8E ^@ http://purl.uniprot.org/uniprot/W5NY27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:CDC16 ^@ http://purl.uniprot.org/uniprot/A0A6P3YJX1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DDX52 ^@ http://purl.uniprot.org/uniprot/W5NYE7 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily. http://togogenome.org/gene/9940:NAPSA ^@ http://purl.uniprot.org/uniprot/W5PWL7 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9940:XKRX ^@ http://purl.uniprot.org/uniprot/A0A6P3YUH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9940:LOC101103772 ^@ http://purl.uniprot.org/uniprot/F5AY94 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9940:PEBP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBI4|||http://purl.uniprot.org/uniprot/A0A6P7D8S1 ^@ Caution|||Similarity ^@ Belongs to the phosphatidylethanolamine-binding protein family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101122362 ^@ http://purl.uniprot.org/uniprot/W5PVE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:SLC43A3 ^@ http://purl.uniprot.org/uniprot/W5PHV7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:ENO2 ^@ http://purl.uniprot.org/uniprot/W5P5C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9940:ELOVL7 ^@ http://purl.uniprot.org/uniprot/W5PB15 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL7 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9940:RAB11B ^@ http://purl.uniprot.org/uniprot/A0A6P3EDP1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AKAP9 ^@ http://purl.uniprot.org/uniprot/W5Q6D6 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/9940:FGF22 ^@ http://purl.uniprot.org/uniprot/A0A836ACT3 ^@ Caution|||Similarity ^@ Belongs to the heparin-binding growth factors family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC35F5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E1V1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TM9SF2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9H8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRR15L ^@ http://purl.uniprot.org/uniprot/A0A6P3E831|||http://purl.uniprot.org/uniprot/A0A6P3TL23 ^@ Caution|||Similarity ^@ Belongs to the PRR15 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM208 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9M2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PYROXD1 ^@ http://purl.uniprot.org/uniprot/W5QGM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.|||sarcomere http://togogenome.org/gene/9940:SOSTDC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8R0|||http://purl.uniprot.org/uniprot/W5PF09 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CPT1A ^@ http://purl.uniprot.org/uniprot/A0A6P3CWI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9940:PNLIPRP3 ^@ http://purl.uniprot.org/uniprot/W5Q4J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9940:INHA ^@ http://purl.uniprot.org/uniprot/A0A0A0WFR4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.|||Secreted http://togogenome.org/gene/9940:EGR1 ^@ http://purl.uniprot.org/uniprot/B8QHP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus|||Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. http://togogenome.org/gene/9940:CAPN1 ^@ http://purl.uniprot.org/uniprot/B2ZA85|||http://purl.uniprot.org/uniprot/W5PVG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C2 family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9940:GFER ^@ http://purl.uniprot.org/uniprot/A0A6P3ERE0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101106825 ^@ http://purl.uniprot.org/uniprot/W5P185 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9940:GALK2 ^@ http://purl.uniprot.org/uniprot/W5QIM0 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/9940:LOC101110266 ^@ http://purl.uniprot.org/uniprot/W5PRB8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:TBL1XR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TB26 ^@ Caution|||Similarity ^@ Belongs to the WD repeat EBI family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:VIP ^@ http://purl.uniprot.org/uniprot/B2KPH2|||http://purl.uniprot.org/uniprot/W5P198 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted|||VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. http://togogenome.org/gene/9940:LGI1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFQ3 ^@ Caution|||Subcellular Location Annotation ^@ Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLPP3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6D0|||http://purl.uniprot.org/uniprot/W5PD88 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAM171B ^@ http://purl.uniprot.org/uniprot/W5Q525 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM171 family.|||Membrane http://togogenome.org/gene/9940:DCUN1D3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQS1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC100526780 ^@ http://purl.uniprot.org/uniprot/E3VW85 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9940:FAM83A ^@ http://purl.uniprot.org/uniprot/A0A6P7EC35|||http://purl.uniprot.org/uniprot/W5PM83 ^@ Caution|||Similarity ^@ Belongs to the FAM83 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PAQR3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9940:ATP5MC2 ^@ http://purl.uniprot.org/uniprot/A0A6P7DLH7|||http://purl.uniprot.org/uniprot/Q06056 ^@ Caution|||Disease Annotation|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase C chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Interacts with DNAJC30; interaction is direct.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||There are three genes which encode the ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins.|||This protein is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).|||Trimethylated by ATPSCKMT at Lys-111. Methylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration. http://togogenome.org/gene/9940:BMP10 ^@ http://purl.uniprot.org/uniprot/W5QF24 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9940:PHYHD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9I7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPAP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZ22 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.|||Belongs to the RPAP2 family.|||Nucleus|||Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLCN5 ^@ http://purl.uniprot.org/uniprot/W5PK60 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.|||Cell membrane|||Endosome membrane|||Golgi apparatus membrane|||Interacts with NEDD4 and NEDD4L.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9940:ATP1A2 ^@ http://purl.uniprot.org/uniprot/W5PEP1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9940:MARCHF3 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECP6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ANTXR2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFA4|||http://purl.uniprot.org/uniprot/W5QC42 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101115698 ^@ http://purl.uniprot.org/uniprot/A0A6P3TKG9 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NIPAL3 ^@ http://purl.uniprot.org/uniprot/W5P9F2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9940:CYP4F21 ^@ http://purl.uniprot.org/uniprot/Q9GLL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ A cytochrome P450 monooxygenase that catalyzes the omega-hydroxylation of prostaglandin E2. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).|||Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9940:PSMC5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E889 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RARS2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBU0|||http://purl.uniprot.org/uniprot/W5PU06 ^@ Caution|||Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TFB2M ^@ http://purl.uniprot.org/uniprot/W5P291 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion http://togogenome.org/gene/9940:CALU ^@ http://purl.uniprot.org/uniprot/W5NYK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CREC family.|||Endoplasmic reticulum membrane|||Golgi apparatus|||Melanosome|||Membrane|||Sarcoplasmic reticulum lumen|||Secreted http://togogenome.org/gene/9940:CSN1S2 ^@ http://purl.uniprot.org/uniprot/P04654 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the alpha-casein family.|||Important role in the capacity of milk to transport calcium phosphate.|||Mammary gland specific. Secreted in milk.|||Secreted http://togogenome.org/gene/9940:COG8 ^@ http://purl.uniprot.org/uniprot/A0A836A0U2|||http://purl.uniprot.org/uniprot/W5P027 ^@ Caution|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SSBP1 ^@ http://purl.uniprot.org/uniprot/W5PX87 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/9940:LOC101123292 ^@ http://purl.uniprot.org/uniprot/W5NTP4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9940:LOC101116626 ^@ http://purl.uniprot.org/uniprot/W5NRZ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9940:TSFM ^@ http://purl.uniprot.org/uniprot/W5P4W0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Mitochondrion http://togogenome.org/gene/9940:GALNT8 ^@ http://purl.uniprot.org/uniprot/A0A836AI33|||http://purl.uniprot.org/uniprot/W5PHV2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TGFB3 ^@ http://purl.uniprot.org/uniprot/W5NVG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.|||extracellular matrix http://togogenome.org/gene/9940:SV2C ^@ http://purl.uniprot.org/uniprot/W5Q5V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9940:HPCAL4 ^@ http://purl.uniprot.org/uniprot/A0A836ACV6|||http://purl.uniprot.org/uniprot/W5QFS9 ^@ Caution|||Function ^@ May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PHKG2 ^@ http://purl.uniprot.org/uniprot/B7U172 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/9940:C9orf72 ^@ http://purl.uniprot.org/uniprot/A0A6P3YJB7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMTC1 ^@ http://purl.uniprot.org/uniprot/W5QE66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9940:ECI1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EG65 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TLR9 ^@ http://purl.uniprot.org/uniprot/Q5I2M4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by proteolytic cleavage of the flexible loop between repeats LRR14 and LRR15 within the ectodomain. Cleavage requires UNC93B1. Proteolytically processed by first removing the majority of the ectodomain by either asparagine endopeptidase (AEP) or a cathepsin followed by a trimming event that is solely cathepsin mediated and required for optimal receptor signaling.|||Belongs to the Toll-like receptor family.|||Endoplasmic reticulum membrane|||Endosome|||Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).|||Lysosome|||Monomer and homodimer. Exists as a monomer in the absence of unmethylated cytidine-phosphate-guanosine (CpG) ligand. Proteolytic processing of an insertion loop (Z-loop) is required for homodimerization upon binding to the unmethylated CpG ligand leading to its activation (By similarity). Interacts with MYD88 via their respective TIR domains (By similarity). Interacts with BTK (By similarity). Interacts (via transmembrane domain) with UNC93B1. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Interacts with SMPDL3B (By similarity).|||phagosome http://togogenome.org/gene/9940:DYNLL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHY1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytoskeleton http://togogenome.org/gene/9940:SERTAD3 ^@ http://purl.uniprot.org/uniprot/A0A836CX40 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RDH5 ^@ http://purl.uniprot.org/uniprot/W5PNM1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9940:IL12B ^@ http://purl.uniprot.org/uniprot/P68220 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).|||Belongs to the IL-12B family.|||Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.|||Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).|||Secreted http://togogenome.org/gene/9940:TMEM60 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8T5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GRPEL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5Q7|||http://purl.uniprot.org/uniprot/W5PPL5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARV1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EM15|||http://purl.uniprot.org/uniprot/W5NZ13 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ITPA ^@ http://purl.uniprot.org/uniprot/A0A6P3EIS4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||Homodimer.|||Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NRN1 ^@ http://purl.uniprot.org/uniprot/W5QBC3 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/9940:MPZL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4Q0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ODF2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YGL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||centrosome http://togogenome.org/gene/9940:BIIIB4 ^@ http://purl.uniprot.org/uniprot/Q29618 ^@ Similarity ^@ Belongs to the KRTAP type 3 family. http://togogenome.org/gene/9940:KIF22 ^@ http://purl.uniprot.org/uniprot/W5P6E6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9940:FNTA ^@ http://purl.uniprot.org/uniprot/C5IJB1 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/9940:SHROOM4 ^@ http://purl.uniprot.org/uniprot/A0A6P3T738|||http://purl.uniprot.org/uniprot/W5PI95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/9940:PLBD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3S7|||http://purl.uniprot.org/uniprot/W5QHX9 ^@ Caution|||Function|||Similarity ^@ Belongs to the phospholipase B-like family.|||Putative phospholipase.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HGD ^@ http://purl.uniprot.org/uniprot/A0A6P3E6R5|||http://purl.uniprot.org/uniprot/W5QF94 ^@ Caution|||Similarity ^@ Belongs to the homogentisate dioxygenase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC25A35 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7X9|||http://purl.uniprot.org/uniprot/W5NR92 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UGCG ^@ http://purl.uniprot.org/uniprot/A0A6P3E7R2|||http://purl.uniprot.org/uniprot/W5P9E0 ^@ Caution|||Similarity ^@ Belongs to the glycosyltransferase 2 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM106B ^@ http://purl.uniprot.org/uniprot/A0A6P3TCP5 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9940:DYNLT4 ^@ http://purl.uniprot.org/uniprot/A0A836APG5|||http://purl.uniprot.org/uniprot/W5PJC5 ^@ Caution|||Similarity ^@ Belongs to the dynein light chain Tctex-type family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GAPDH ^@ http://purl.uniprot.org/uniprot/A0A6P9FRF8|||http://purl.uniprot.org/uniprot/D7R7V6 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PFDN2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4N1|||http://purl.uniprot.org/uniprot/W5PID4 ^@ Caution|||Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAM114A2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4Y4|||http://purl.uniprot.org/uniprot/A0A6P3TP31 ^@ Caution|||Similarity ^@ Belongs to the FAM114 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RAB11FIP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFV6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MANBAL ^@ http://purl.uniprot.org/uniprot/W5Q8Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0239 family.|||Membrane http://togogenome.org/gene/9940:MPP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ES90 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||stereocilium http://togogenome.org/gene/9940:TMEM79 ^@ http://purl.uniprot.org/uniprot/A0A836D9Z0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DCAF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TE50|||http://purl.uniprot.org/uniprot/W5PCE1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPRBP/DCAF1 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRKAG1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YIN1 ^@ Caution|||Similarity|||Subunit ^@ AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.|||Belongs to the 5'-AMP-activated protein kinase gamma subunit family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GK ^@ http://purl.uniprot.org/uniprot/W5Q9M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FGGY kinase family.|||Cytoplasm http://togogenome.org/gene/9940:LOC101113787 ^@ http://purl.uniprot.org/uniprot/W5Q615 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:SERINC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGP8|||http://purl.uniprot.org/uniprot/W5PEF3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ABI1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EK40|||http://purl.uniprot.org/uniprot/W5Q3F7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9940:HSP90B1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TF14 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 90 family.|||Melanosome|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NIPA2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E638|||http://purl.uniprot.org/uniprot/A0A6P3TCA4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PDCD11 ^@ http://purl.uniprot.org/uniprot/W5P0M8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9940:LOC101123492 ^@ http://purl.uniprot.org/uniprot/W5PAY1 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:SSR3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E727|||http://purl.uniprot.org/uniprot/W5NYA9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-gamma family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101111300 ^@ http://purl.uniprot.org/uniprot/A0A836A176 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tdpoz family.|||Nucleus speckle|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MKRN2 ^@ http://purl.uniprot.org/uniprot/W5Q2I1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9940:EFNA5 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDA9|||http://purl.uniprot.org/uniprot/W5QBQ2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FKBP7 ^@ http://purl.uniprot.org/uniprot/A0A836AJS2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GADD45A ^@ http://purl.uniprot.org/uniprot/A0A6P3E572|||http://purl.uniprot.org/uniprot/W5PNZ3 ^@ Caution|||Similarity ^@ Belongs to the GADD45 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLSCR4 ^@ http://purl.uniprot.org/uniprot/A0A6P3E576|||http://purl.uniprot.org/uniprot/A0A6P3YJC9 ^@ Caution|||Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM126B ^@ http://purl.uniprot.org/uniprot/W5P4W9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:CD27 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3Y0|||http://purl.uniprot.org/uniprot/W5PER9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:INHBC ^@ http://purl.uniprot.org/uniprot/A0A836A899 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SMAD7 ^@ http://purl.uniprot.org/uniprot/W5P0W2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:GBF1 ^@ http://purl.uniprot.org/uniprot/W5Q8R3 ^@ Subcellular Location Annotation ^@ Golgi apparatus http://togogenome.org/gene/9940:STON2 ^@ http://purl.uniprot.org/uniprot/W5NYA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Stoned B family.|||Cytoplasm http://togogenome.org/gene/9940:HOXB7 ^@ http://purl.uniprot.org/uniprot/W5PAD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9940:PACSIN2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TKP6|||http://purl.uniprot.org/uniprot/A0A6P3YKT8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PACSIN family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome membrane|||Membrane|||Recycling endosome membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||caveola|||cytoskeleton|||ruffle membrane http://togogenome.org/gene/9940:NDUFB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEC2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KCNK3 ^@ http://purl.uniprot.org/uniprot/A0A6P3CXB1|||http://purl.uniprot.org/uniprot/E5L8E3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KLC4 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENN0|||http://purl.uniprot.org/uniprot/A0A6P7D7T4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytoskeleton http://togogenome.org/gene/9940:C7H15orf65 ^@ http://purl.uniprot.org/uniprot/A0A6P3TFT4|||http://purl.uniprot.org/uniprot/W5QIB1 ^@ Caution|||Subcellular Location Annotation|||Subunit ^@ Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cilium axoneme http://togogenome.org/gene/9940:FARSB ^@ http://purl.uniprot.org/uniprot/A0A836AGU2|||http://purl.uniprot.org/uniprot/W5QGI4 ^@ Caution|||Similarity ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HEPACAM ^@ http://purl.uniprot.org/uniprot/A0A6P3T8G1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PIP5K1A ^@ http://purl.uniprot.org/uniprot/A0A6P3E740 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HNRNPA3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E192 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:RPL30 ^@ http://purl.uniprot.org/uniprot/A0A836A0U0|||http://purl.uniprot.org/uniprot/W5PMC5 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC2A12 ^@ http://purl.uniprot.org/uniprot/W5PZ66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane http://togogenome.org/gene/9940:UBLCP1 ^@ http://purl.uniprot.org/uniprot/W5PU58 ^@ Function|||Subcellular Location Annotation ^@ Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.|||Nucleus http://togogenome.org/gene/9940:CD3G ^@ http://purl.uniprot.org/uniprot/A0A6P3EG79 ^@ Caution|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Membrane|||The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CEP20 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE51|||http://purl.uniprot.org/uniprot/W5PHQ3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP43 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||centriole|||cilium basal body http://togogenome.org/gene/9940:SERBP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3DYD4|||http://purl.uniprot.org/uniprot/W5PNR4 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FMNL3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TLF8|||http://purl.uniprot.org/uniprot/W5QAL6 ^@ Caution|||Similarity ^@ Belongs to the formin homology family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZZZ3 ^@ http://purl.uniprot.org/uniprot/A0A836D6K4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RAB33A ^@ http://purl.uniprot.org/uniprot/A0A6P3EFA9|||http://purl.uniprot.org/uniprot/W5Q1J6 ^@ Caution|||Similarity ^@ Belongs to the small GTPase superfamily. Rab family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PAGR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3T9V5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101107908 ^@ http://purl.uniprot.org/uniprot/W5PWM7|||http://purl.uniprot.org/uniprot/W5PWM8 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9940:CAV2 ^@ http://purl.uniprot.org/uniprot/Q09YJ1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the caveolin family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).|||Monomer or homodimer (By similarity). Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity).|||Nucleus|||Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By similarity).|||caveola http://togogenome.org/gene/9940:RASGRP3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TJ60 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9940:ST3GAL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TRV9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRIM1 ^@ http://purl.uniprot.org/uniprot/W5PEB9 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/9940:MED4 ^@ http://purl.uniprot.org/uniprot/A0A6P7E063|||http://purl.uniprot.org/uniprot/A0A836D264 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 4 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MSGN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E2G2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GYS2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3P8 ^@ Caution|||Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/9940:BSP1 ^@ http://purl.uniprot.org/uniprot/B7VBV2 ^@ Caution|||Similarity ^@ Belongs to the seminal plasma protein family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:CFTR ^@ http://purl.uniprot.org/uniprot/Q00555 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.|||Binds and hydrolyzes ATP via the two cytoplasmic ABC transporter nucleotide-binding domains. The two ATP-binding domains interact with each other, forming a head-to-tail dimer. Normal ATPase activity requires interaction between the two domains. The first ABC transporter nucleotide-binding domain has no ATPase activity by itself.|||Cell membrane|||Early endosome membrane|||Endoplasmic reticulum membrane|||Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).|||Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and SLC9A3R1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through SLC9A3R1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation (By similarity).|||N-glycosylated.|||Nucleus|||Phosphorylated; cAMP treatment promotes phosphorylation and activates the channel. Dephosphorylation decreases the ATPase activity (in vitro). Phosphorylation at PKA sites activates the channel. Phosphorylation at PKC sites enhances the response to phosphorylation by PKA. Phosphorylated by AMPK; this inhibits channel activity.|||Recycling endosome membrane|||The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, SLC9A3R1/EBP50 complex.|||The disordered R region mediates channel activation when it is phosphorylated, but not in the absence of phosphorylation.|||Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes enhances its endocytic recycling to the cell membrane. Ubiquitinated by RNF185 during ER stress. Ubiquitinated by MARCHF2 (By similarity). http://togogenome.org/gene/9940:TKDP1 ^@ http://purl.uniprot.org/uniprot/Q29428 ^@ Developmental Stage|||Function|||Subcellular Location Annotation|||Tissue Specificity ^@ Expressed only in the trophectoderm, which forms the outer epithelial layer of the trophoblast.|||Maximal expression at days 14 and 16 of pregnancy.|||May play a role in mediating maternal-conceptus interactions in the immediate preimplantation period. Does not seem to have proteinase inhibitory activity.|||Secreted http://togogenome.org/gene/9940:AK7 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC03 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CMTR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YRY7 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with POLR2A (via C-terminus).|||Nucleus|||S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).|||S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARL3 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQM1|||http://purl.uniprot.org/uniprot/C5IWU4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||centrosome http://togogenome.org/gene/9940:BCL2L14 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB87|||http://purl.uniprot.org/uniprot/W5QI98 ^@ Caution|||Similarity ^@ Belongs to the Bcl-2 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MANSC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E884 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GC ^@ http://purl.uniprot.org/uniprot/A0A836A4N3|||http://purl.uniprot.org/uniprot/W5PTG9 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NGLY1 ^@ http://purl.uniprot.org/uniprot/W5P200 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transglutaminase-like superfamily. PNGase family.|||Cytoplasm http://togogenome.org/gene/9940:TXNL4B ^@ http://purl.uniprot.org/uniprot/A0A6P3EC91|||http://purl.uniprot.org/uniprot/A0A6P3EJK0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101104224 ^@ http://purl.uniprot.org/uniprot/W5QDC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG10 glucosyltransferase family.|||Membrane http://togogenome.org/gene/9940:TADA1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4P6|||http://purl.uniprot.org/uniprot/W5PQI8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TADA1 family.|||Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.|||Nucleus|||Probably involved in transcriptional regulation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BCLAF3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YU93 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/9940:NDUFA7 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9B7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA7 subunit family.|||Complex I is composed of 45 different subunits.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RBX1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E417 ^@ Caution|||Similarity ^@ Belongs to the RING-box family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC39A12 ^@ http://purl.uniprot.org/uniprot/W5PT04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Membrane http://togogenome.org/gene/9940:TNRC6B ^@ http://purl.uniprot.org/uniprot/W5Q712 ^@ Similarity ^@ Belongs to the GW182 family. http://togogenome.org/gene/9940:LOC101115061 ^@ http://purl.uniprot.org/uniprot/W5Q7B2 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:BACE1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EG74|||http://purl.uniprot.org/uniprot/W5P5U5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Membrane|||Membrane raft|||Recycling endosome|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||trans-Golgi network http://togogenome.org/gene/9940:YKT6 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC11|||http://purl.uniprot.org/uniprot/W5Q2V0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. http://togogenome.org/gene/9940:GIT2 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENR1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FEN1 ^@ http://purl.uniprot.org/uniprot/C8BKD0|||http://purl.uniprot.org/uniprot/W5Q231 ^@ Caution|||Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300.|||Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300. Can bind simultaneously to both PCNA and EP300. Interacts with DDX11.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methylation at Arg-184 by PRMT5 impedes Ser-179 phosphorylation and increases interaction with PCNA.|||Methylation at Arg-192 by PRMT5 impedes Ser-187 phosphorylation and increases interaction with PCNA.|||Mitochondrion|||Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Phosphorylation at Ser-179 by CDK2 occurs during late S-phase and results in dissociation from PCNA.|||Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Phosphorylation at Ser-187 by CDK2 occurs during late S-phase and results in dissociation from PCNA.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.|||Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300; can bind simultaneously to both PCNA and EP300. Interacts with PCNA; can bind simultaneously to both PCNA and EP300. Interacts with DDX11; this interaction is direct and increases flap endonuclease activity of FEN1. Interacts with WDR4; regulating its endonuclease activity.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9940:UBA6 ^@ http://purl.uniprot.org/uniprot/W5PBH2 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9940:ZCCHC10 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE03 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:APOM ^@ http://purl.uniprot.org/uniprot/A0A6P3ENU5|||http://purl.uniprot.org/uniprot/A0A6P7D7D7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family. Highly divergent.|||Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.|||Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AP1G1 ^@ http://purl.uniprot.org/uniprot/W5P0Z7 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9940:MFSD11 ^@ http://purl.uniprot.org/uniprot/A0A6P3TS43|||http://purl.uniprot.org/uniprot/A0A836CXK3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ANAPC4 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6T3 ^@ Caution|||Function|||Similarity ^@ Belongs to the APC4 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TIA1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E2I7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101102714 ^@ http://purl.uniprot.org/uniprot/M9PPI3 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 22 family.|||Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. http://togogenome.org/gene/9940:IGFBP5 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQC5|||http://purl.uniprot.org/uniprot/B3GS77 ^@ Caution|||Function|||Subcellular Location Annotation ^@ IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101108419 ^@ http://purl.uniprot.org/uniprot/W5PNP2 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/9940:KRT82 ^@ http://purl.uniprot.org/uniprot/W5Q6H2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9940:ILK ^@ http://purl.uniprot.org/uniprot/A0A6P3T4M6|||http://purl.uniprot.org/uniprot/A0A6P3TF04|||http://purl.uniprot.org/uniprot/H9CH14 ^@ Caution|||Subcellular Location Annotation ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||focal adhesion|||lamellipodium|||sarcomere http://togogenome.org/gene/9940:IPO7 ^@ http://purl.uniprot.org/uniprot/A0A835ZZ83|||http://purl.uniprot.org/uniprot/W5PT14 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCDC190 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7I3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLEKHA8 ^@ http://purl.uniprot.org/uniprot/W5PF15 ^@ Subcellular Location Annotation ^@ Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9940:YARS2 ^@ http://purl.uniprot.org/uniprot/W5QDG4 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9940:TOMM5 ^@ http://purl.uniprot.org/uniprot/W5PP75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom5 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9940:DCK ^@ http://purl.uniprot.org/uniprot/W5PR96 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9940:ALG6 ^@ http://purl.uniprot.org/uniprot/W5PIT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.|||Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9940:GLYCTK ^@ http://purl.uniprot.org/uniprot/W5P6K4 ^@ Similarity ^@ Belongs to the glycerate kinase type-2 family. http://togogenome.org/gene/9940:CAB39L ^@ http://purl.uniprot.org/uniprot/A0A6P3E7D8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/9940:DUS1L ^@ http://purl.uniprot.org/uniprot/A0A6P3TID6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CRELD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3T753 ^@ Caution|||Similarity ^@ Belongs to the CRELD family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:LOC101122122 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE32|||http://purl.uniprot.org/uniprot/W5PHD1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Belongs to the intercrine gamma family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PTCD3 ^@ http://purl.uniprot.org/uniprot/W5QHG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS39 family.|||Mitochondrion http://togogenome.org/gene/9940:PLA2G2C ^@ http://purl.uniprot.org/uniprot/W5PHZ6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9940:LOC101111607 ^@ http://purl.uniprot.org/uniprot/A0A6P3E209|||http://purl.uniprot.org/uniprot/A0A6P3TI08 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZBTB8OS ^@ http://purl.uniprot.org/uniprot/A0A6P3E6M7|||http://purl.uniprot.org/uniprot/W5QID8 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the archease family.|||Component of the tRNA-splicing ligase complex.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CPSF2 ^@ http://purl.uniprot.org/uniprot/A0A835ZPH8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PHACTR3 ^@ http://purl.uniprot.org/uniprot/W5Q2S3 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/9940:LOC101116896 ^@ http://purl.uniprot.org/uniprot/W5QIL5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9940:LOC101107098 ^@ http://purl.uniprot.org/uniprot/A0A6P3EA32|||http://purl.uniprot.org/uniprot/W5NTE7 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL6 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRPS9 ^@ http://purl.uniprot.org/uniprot/A0A6P3E2T7|||http://purl.uniprot.org/uniprot/W5PU00 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uS9 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KRR1 ^@ http://purl.uniprot.org/uniprot/W5PZK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KRR1 family.|||Component of the ribosomal small subunit (SSU) processome.|||Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.|||nucleolus http://togogenome.org/gene/9940:AGTR2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TBB4|||http://purl.uniprot.org/uniprot/Q28929 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Helix VIII may act as a gatekeeper for either suppression or activation of the receptor, depending on post-translational modifications and interactions with various receptor partners. Helix VIII is found in a non-canonical position, stabilizing the active-like state, but at the same time preventing the recruitment of G-proteins or beta-arrestins. Upon switching to a membrane-bound conformation, helix VIII can support the recruitment of G proteins and beta-arrestins.|||Interacts with MTUS1.|||Membrane|||Receptor for angiotensin II, a vasoconstricting peptide. Signals primarily via a non-canonical G-protein- and beta-arrestin independent pathways. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KCNJ8 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC81|||http://purl.uniprot.org/uniprot/W5QGC8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDCA8 ^@ http://purl.uniprot.org/uniprot/A0A836ANX9|||http://purl.uniprot.org/uniprot/W5QEZ6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the borealin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||centromere http://togogenome.org/gene/9940:PKD1L2 ^@ http://purl.uniprot.org/uniprot/W5PEX8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polycystin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9940:SREK1IP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB35 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RASGRP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQM4 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9940:LOC101106166 ^@ http://purl.uniprot.org/uniprot/W5Q5K4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/9940:TSPO ^@ http://purl.uniprot.org/uniprot/Q9GMC9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TspO/BZRP family.|||Interacts with TSPOAP1 (By similarity). Interacts with MOST-1 (By similarity). May interact with STAR.|||Mitochondrion membrane|||Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:11145616). http://togogenome.org/gene/9940:MTHFD1 ^@ http://purl.uniprot.org/uniprot/W5QJ32 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.|||In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. http://togogenome.org/gene/9940:APOD ^@ http://purl.uniprot.org/uniprot/W5QGP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9940:LOC101116991 ^@ http://purl.uniprot.org/uniprot/W5PUT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9940:KEF53_p10 ^@ http://purl.uniprot.org/uniprot/A0A0E3LZY8|||http://purl.uniprot.org/uniprot/O78750 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Binds a dinuclear copper A center per subunit.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome (By similarity). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:27654913). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16 (By similarity).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9940:LYPLA2 ^@ http://purl.uniprot.org/uniprot/W5PB50 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/9940:TIMM17A ^@ http://purl.uniprot.org/uniprot/A0A6P3YKM0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM71 ^@ http://purl.uniprot.org/uniprot/A0A836AC59 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C1QTNF6 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC46 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SDR16C5 ^@ http://purl.uniprot.org/uniprot/C5IS98 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9940:LOC101108911 ^@ http://purl.uniprot.org/uniprot/W5Q4A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:SDHC ^@ http://purl.uniprot.org/uniprot/A0A6P3E4N8|||http://purl.uniprot.org/uniprot/W5PJW1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b560 family.|||Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZNF711 ^@ http://purl.uniprot.org/uniprot/A0A6P7DIQ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:CRHR1 ^@ http://purl.uniprot.org/uniprot/O62772 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 2 family.|||C-terminal Ser or Thr residues may be phosphorylated.|||Cell membrane|||Endosome|||G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.|||Heterodimer; heterodimerizes with GPER1. Interacts (via N-terminal extracellular domain) with CRH and UCN. Interacts with DLG1; this inhibits endocytosis of CRHR1 after agonist binding (By similarity).|||Phosphorylation at Ser-301 by PKA prevents maximal coupling to Gq-protein, and thereby negatively regulates downstream signaling.|||The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure (By similarity). http://togogenome.org/gene/9940:TAPBPL ^@ http://purl.uniprot.org/uniprot/A0A6P3ECG5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CD79B ^@ http://purl.uniprot.org/uniprot/W5PX57 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9940:CCDC167 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJ13 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GAR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E577 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GAR1 family.|||Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.|||nucleolus http://togogenome.org/gene/9940:SF3B3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJ99 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IL7 ^@ http://purl.uniprot.org/uniprot/Q28540 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-7/IL-9 family.|||Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis. Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG. Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5.|||Interacts with IL7R and CSF2RG.|||Secreted http://togogenome.org/gene/9940:GPANK1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YP94 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LSM2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EPY5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SEC24B ^@ http://purl.uniprot.org/uniprot/W5P912 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9940:ATG101 ^@ http://purl.uniprot.org/uniprot/A0A6P3E320 ^@ Caution|||Similarity ^@ Belongs to the ATG101 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101115778 ^@ http://purl.uniprot.org/uniprot/W5QII5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9940:PSMA8 ^@ http://purl.uniprot.org/uniprot/W5PB07 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9940:PRLHR ^@ http://purl.uniprot.org/uniprot/A0A6P3CWY0|||http://purl.uniprot.org/uniprot/B2KTD0 ^@ Caution|||Similarity ^@ Belongs to the G-protein coupled receptor 1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TNFAIP3 ^@ http://purl.uniprot.org/uniprot/W5NQZ0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9940:NUDT7 ^@ http://purl.uniprot.org/uniprot/W5PCU2 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. PCD1 subfamily. http://togogenome.org/gene/9940:TNFAIP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9R4 ^@ Caution|||Similarity ^@ Belongs to the BACURD family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NUP43 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6Z9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLA2G1B ^@ http://purl.uniprot.org/uniprot/W5PR24 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9940:IFI30 ^@ http://purl.uniprot.org/uniprot/F1ASZ5 ^@ Similarity|||Subunit ^@ Belongs to the GILT family.|||Dimer; disulfide-linked. http://togogenome.org/gene/9940:ENTPD6 ^@ http://purl.uniprot.org/uniprot/W5PAG5 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9940:LAMP3 ^@ http://purl.uniprot.org/uniprot/W5QHK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane http://togogenome.org/gene/9940:PRDM10 ^@ http://purl.uniprot.org/uniprot/W5PYN6 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9940:GSTCD ^@ http://purl.uniprot.org/uniprot/A0A6P7E8U1|||http://purl.uniprot.org/uniprot/A0A836AEX7 ^@ Caution|||Similarity ^@ Belongs to the GSTCD family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPM1K ^@ http://purl.uniprot.org/uniprot/W5NU64 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9940:TPP1 ^@ http://purl.uniprot.org/uniprot/W5Q686 ^@ Cofactor ^@ Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9940:GNPDA1 ^@ http://purl.uniprot.org/uniprot/W5NUG3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/9940:B3GNT9 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC79|||http://purl.uniprot.org/uniprot/A0A6P3TZ08 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PFKFB3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YKN7 ^@ Caution|||Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the phosphoglycerate mutase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SCGN ^@ http://purl.uniprot.org/uniprot/A0A6P3ECX7|||http://purl.uniprot.org/uniprot/W5NZ64 ^@ Caution|||Subcellular Location Annotation ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||secretory vesicle membrane http://togogenome.org/gene/9940:KIF2A ^@ http://purl.uniprot.org/uniprot/A0A6P3YRD9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9940:SENP3 ^@ http://purl.uniprot.org/uniprot/W5PY22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C48 family.|||nucleolus http://togogenome.org/gene/9940:MORN3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHU9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101104697 ^@ http://purl.uniprot.org/uniprot/W5Q1S2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:SARS1 ^@ http://purl.uniprot.org/uniprot/W5QCS4 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. http://togogenome.org/gene/9940:PBLD ^@ http://purl.uniprot.org/uniprot/A0A6P3EGP1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OGDH ^@ http://purl.uniprot.org/uniprot/W5PZR4 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/9940:TAPT1 ^@ http://purl.uniprot.org/uniprot/W5PKF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAPT1 family.|||Membrane http://togogenome.org/gene/9940:LOC101107056 ^@ http://purl.uniprot.org/uniprot/W5P5D3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9940:LOC106991069 ^@ http://purl.uniprot.org/uniprot/A0A835ZJ51|||http://purl.uniprot.org/uniprot/K4P217 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL22 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DNAH3 ^@ http://purl.uniprot.org/uniprot/W5PWS5 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/9940:NUP98 ^@ http://purl.uniprot.org/uniprot/W5NVY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin GLFG family.|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/9940:LAPTM4A ^@ http://purl.uniprot.org/uniprot/W5Q6M3 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9940:LOC101119685 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQP7 ^@ Caution|||Subcellular Location Annotation|||Subunit ^@ Interacts with CD45/PTPRC.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BAMBI ^@ http://purl.uniprot.org/uniprot/A0A835ZXZ3|||http://purl.uniprot.org/uniprot/Q8HYZ0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BAMBI family.|||Membrane|||Negatively regulates TGF-beta signaling.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPS6 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9D6|||http://purl.uniprot.org/uniprot/W5PXV8 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZCRB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDX0|||http://purl.uniprot.org/uniprot/A0A6P3TPY4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AP3M2 ^@ http://purl.uniprot.org/uniprot/W5NYM8 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/9940:LOC101111215 ^@ http://purl.uniprot.org/uniprot/A0A6P3EKA6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCTS1 family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NUS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBM8 ^@ Caution|||Similarity ^@ Belongs to the UPP synthase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZNF143 ^@ http://purl.uniprot.org/uniprot/A0A6P3EM42 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C9 ^@ http://purl.uniprot.org/uniprot/W5PID9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted|||Target cell membrane http://togogenome.org/gene/9940:LOC101119356 ^@ http://purl.uniprot.org/uniprot/A0A836AN27|||http://purl.uniprot.org/uniprot/W5NWA3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HOXB5 ^@ http://purl.uniprot.org/uniprot/W5PAS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9940:PSMD9 ^@ http://purl.uniprot.org/uniprot/A0A6P3EM77|||http://purl.uniprot.org/uniprot/W5PSC3 ^@ Caution|||Similarity ^@ Belongs to the proteasome subunit p27 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AQP7 ^@ http://purl.uniprot.org/uniprot/A0A6P3E0N6|||http://purl.uniprot.org/uniprot/A0A6P3TGM9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PANX3 ^@ http://purl.uniprot.org/uniprot/A0A6P3ED75|||http://purl.uniprot.org/uniprot/W5PL29 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions and the hemichannels.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||gap junction http://togogenome.org/gene/9940:ARAF ^@ http://purl.uniprot.org/uniprot/A0A6P3CXM2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/9940:DBI ^@ http://purl.uniprot.org/uniprot/A0A6P3E1H6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TGIF2 ^@ http://purl.uniprot.org/uniprot/W5Q2W8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:RELL2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4U4|||http://purl.uniprot.org/uniprot/A0A6P7E4W6 ^@ Caution|||Similarity ^@ Belongs to the RELT family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC106990092 ^@ http://purl.uniprot.org/uniprot/A0A835ZM35|||http://purl.uniprot.org/uniprot/P62896 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme c group covalently per subunit.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C18H14orf28 ^@ http://purl.uniprot.org/uniprot/A0A6P7D4N1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:YES1 ^@ http://purl.uniprot.org/uniprot/W5PIG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9940:LOC101111566 ^@ http://purl.uniprot.org/uniprot/W5Q8H8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/9940:DCTN4 ^@ http://purl.uniprot.org/uniprot/A0A6P3ED33 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IARS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3T845 ^@ Caution|||Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101109826 ^@ http://purl.uniprot.org/uniprot/W5P8U0 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:CASP3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YQC8 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9940:CORO6 ^@ http://purl.uniprot.org/uniprot/A0A836A964 ^@ Caution|||Similarity ^@ Belongs to the WD repeat coronin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101104041 ^@ http://purl.uniprot.org/uniprot/W5QEC5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TTC30/dfy-1/fleer family.|||Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.|||cilium http://togogenome.org/gene/9940:ATP2A1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ERL0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FERMT2 ^@ http://purl.uniprot.org/uniprot/A0A836D1N1 ^@ Caution|||Similarity ^@ Belongs to the kindlin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GLIPR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7H0 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CWC25 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHD3|||http://purl.uniprot.org/uniprot/W5PJN5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CWC25 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KCNN3 ^@ http://purl.uniprot.org/uniprot/W5NYB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:LCA5L ^@ http://purl.uniprot.org/uniprot/W5PJ29 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/9940:LOC100101238 ^@ http://purl.uniprot.org/uniprot/A6N7G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9940:CDK12 ^@ http://purl.uniprot.org/uniprot/A0A6P3E844 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RARG ^@ http://purl.uniprot.org/uniprot/T1UNQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9940:CACNB3 ^@ http://purl.uniprot.org/uniprot/W5QCW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||Cytoplasm http://togogenome.org/gene/9940:S100A16 ^@ http://purl.uniprot.org/uniprot/A0A6P3E767|||http://purl.uniprot.org/uniprot/A0A6P3TJ17 ^@ Caution|||Similarity ^@ Belongs to the S-100 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:THEM5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E750 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CD70 ^@ http://purl.uniprot.org/uniprot/W5P639 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9940:CDC5L ^@ http://purl.uniprot.org/uniprot/W5PKH2 ^@ Similarity ^@ Belongs to the CEF1 family. http://togogenome.org/gene/9940:NDUFA12 ^@ http://purl.uniprot.org/uniprot/A0A8N7XJ18 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA12 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCR8 ^@ http://purl.uniprot.org/uniprot/W5PX65 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9940:APEH ^@ http://purl.uniprot.org/uniprot/A0A6P3EPI4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S9C family.|||Cytoplasm|||Homotetramer.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser. http://togogenome.org/gene/9940:TXN ^@ http://purl.uniprot.org/uniprot/P50413 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thioredoxin family.|||Cytoplasm|||Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner (By similarity).|||In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins (By similarity).|||Nucleus|||Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity).|||Secreted http://togogenome.org/gene/9940:LOC101103771 ^@ http://purl.uniprot.org/uniprot/W5NQJ0 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9940:TMEM242 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC18 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM242 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EIF2B1 ^@ http://purl.uniprot.org/uniprot/W5NYY0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2B alpha/beta/delta subunits family.|||Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.|||Complex of five different subunits; alpha, beta, gamma, delta and epsilon. http://togogenome.org/gene/9940:STAC ^@ http://purl.uniprot.org/uniprot/W5Q4J8 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9940:IGFBP6 ^@ http://purl.uniprot.org/uniprot/B5AN56 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9940:VWA5A ^@ http://purl.uniprot.org/uniprot/A0A6P3EPU2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ILF2 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZP2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CFAP77 ^@ http://purl.uniprot.org/uniprot/A0A6P3E459 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:VTI1B ^@ http://purl.uniprot.org/uniprot/A0A836AEX3|||http://purl.uniprot.org/uniprot/W5QJ55 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DNASE1L1 ^@ http://purl.uniprot.org/uniprot/W5P4H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNase I family.|||Nucleus envelope|||Zymogen granule http://togogenome.org/gene/9940:LOC101113937 ^@ http://purl.uniprot.org/uniprot/W5PRF6 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:CYP2C19 ^@ http://purl.uniprot.org/uniprot/F1CGV0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9940:FBXO38 ^@ http://purl.uniprot.org/uniprot/A0A6P3TSL7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SF3B6 ^@ http://purl.uniprot.org/uniprot/A0A6P3E250|||http://purl.uniprot.org/uniprot/W5Q8S3 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101120067 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAV4|||http://purl.uniprot.org/uniprot/W5QAG8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PSMB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E722|||http://purl.uniprot.org/uniprot/W5P500 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TCTE1 ^@ http://purl.uniprot.org/uniprot/A0A6P7D6N0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZDHHC13 ^@ http://purl.uniprot.org/uniprot/W5PGN8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9940:EIF2B2 ^@ http://purl.uniprot.org/uniprot/W5NTZ6 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/9940:CAST ^@ http://purl.uniprot.org/uniprot/Q95208 ^@ Domain|||Function|||Similarity ^@ Belongs to the protease inhibitor I27 (calpastatin) family.|||Each of the four flexible inhibitory domains can inhibit one calcium-bound calpain molecule by occupying both sides of the active site.|||Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue (By similarity). http://togogenome.org/gene/9940:FICD ^@ http://purl.uniprot.org/uniprot/A0A6P3TGJ1 ^@ Caution|||Similarity ^@ Belongs to the fic family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM174 ^@ http://purl.uniprot.org/uniprot/A0A6P3EN34 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101115927 ^@ http://purl.uniprot.org/uniprot/A0A6P3E736|||http://purl.uniprot.org/uniprot/W5P0X1 ^@ Caution|||Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TTLL1 ^@ http://purl.uniprot.org/uniprot/A0A6P7DZ77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin polyglutamylase family.|||cilium basal body http://togogenome.org/gene/9940:TNF ^@ http://purl.uniprot.org/uniprot/A5YBV0|||http://purl.uniprot.org/uniprot/P23383 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity).|||Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.|||Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.|||Homotrimer. Interacts with SPPL2B (By similarity).|||Homotrimer. Interacts with SPPL2B.|||Membrane|||O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.|||Secreted|||The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.|||The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).|||The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.|||The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity).|||The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.|||The soluble form is demyristoylated by SIRT6, promoting its secretion. http://togogenome.org/gene/9940:INPP4B ^@ http://purl.uniprot.org/uniprot/W5PQC2 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/9940:TTC4 ^@ http://purl.uniprot.org/uniprot/W5PC03 ^@ Similarity ^@ Belongs to the TTC4 family. http://togogenome.org/gene/9940:DRC1 ^@ http://purl.uniprot.org/uniprot/W5QBW2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DRC1 family.|||Component of the nexin-dynein regulatory complex (N-DRC).|||cilium axoneme|||flagellum axoneme http://togogenome.org/gene/9940:LOC101110922 ^@ http://purl.uniprot.org/uniprot/W5PPP0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9940:STXBP3 ^@ http://purl.uniprot.org/uniprot/W5QCA2 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9940:RSPH9 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENN6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MITF ^@ http://purl.uniprot.org/uniprot/W5PJC4|||http://purl.uniprot.org/uniprot/W5PJC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9940:SCD5 ^@ http://purl.uniprot.org/uniprot/A9QVT2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/9940:SFN ^@ http://purl.uniprot.org/uniprot/O77642 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ 14-3-3 proteins have been shown to be PKC activators, but this effect could be non-specific and only due to the acidic nature of the protein.|||Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (By similarity).|||Belongs to the 14-3-3 family.|||Cytoplasm|||Homodimer. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29 and VPS35. Interacts with KRT17. Interacts with GAB2 and SAMSN1 (By similarity). Interacts with SRPK2 (By similarity). Interacts with COPS6 (By similarity). Interacts with COP1; this interaction leads to proteasomal degradation (By similarity). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB (By similarity). Interacts with SLITRK1 (By similarity). Interacts with LRRK2; this interaction is dependent on LRRK2 phosphorylation (By similarity).|||Nucleus|||Secreted|||Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation (By similarity). http://togogenome.org/gene/9940:LOC101116841 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC77 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MIP ^@ http://purl.uniprot.org/uniprot/A0A836D410|||http://purl.uniprot.org/uniprot/Q6J8I9 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Aquaporins contain two tandem repeats each containing two membrane-spanning helices and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Each tandem repeat contains a loop and a short helix that enter and leave the lipid bilayer on the same side.|||Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Detected in eye lens (at protein level).|||Fatty acylated at Met-1 and Lys-238. The acyl modifications, in decreasing order of ion abundance, are: oleoyl (C18:1) > palmitoyl (C16:0) > stearoyl (C18:0) > eicosenoyl (C20:1) > dihomo-gamma-linolenoyl (C20:3) > palmitoleoyl (C16:1) > eicosadienoyl (C20:2).|||Homotetramer. Homooctamer formed by head-to-head interaction between homotetramers from adjoining membranes. Interacts with CALM; one CALM molecule interacts with the cytoplasmic domains of two aquaporins, leading to channel closure. Interacts (via C-terminus) with BFSP1 (via C-terminus) in aged lens fiber cells (By similarity).|||Membrane|||Subject to partial proteolytic cleavage in the eye lens core. Partial proteolysis promotes interactions between tetramers from adjoining membranes.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity).|||gap junction http://togogenome.org/gene/9940:LOC101119916 ^@ http://purl.uniprot.org/uniprot/W5P233 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:TSPYL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGR8 ^@ Caution|||Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPH3AL ^@ http://purl.uniprot.org/uniprot/A0A6P3E7R5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NUDT1 ^@ http://purl.uniprot.org/uniprot/A0A835ZQM8 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family.|||Monomer.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C2CD5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3P1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CNIH4 ^@ http://purl.uniprot.org/uniprot/W5Q3Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9940:NEURL2 ^@ http://purl.uniprot.org/uniprot/W5PAB2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9940:RBBP4 ^@ http://purl.uniprot.org/uniprot/A0A6P3E1U0|||http://purl.uniprot.org/uniprot/A0A6P7DI30 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GPD1L ^@ http://purl.uniprot.org/uniprot/A0A6P3EPA0|||http://purl.uniprot.org/uniprot/W5Q024 ^@ Caution|||Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POLR1B ^@ http://purl.uniprot.org/uniprot/A0A6P3E2D0 ^@ Caution|||Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101121301 ^@ http://purl.uniprot.org/uniprot/A0A6P3TI37 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MYB ^@ http://purl.uniprot.org/uniprot/W5PZV6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:DHDH ^@ http://purl.uniprot.org/uniprot/A0A6P3ELK2 ^@ Caution|||Similarity ^@ Belongs to the Gfo/Idh/MocA family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MAGOHB ^@ http://purl.uniprot.org/uniprot/W5QIE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/9940:RARA ^@ http://purl.uniprot.org/uniprot/W5PXH0|||http://purl.uniprot.org/uniprot/W5PXH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9940:SPAG7 ^@ http://purl.uniprot.org/uniprot/W5P5C2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:ADORA3 ^@ http://purl.uniprot.org/uniprot/A0A836ALV2|||http://purl.uniprot.org/uniprot/P35342|||http://purl.uniprot.org/uniprot/W5QED6 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Most abundant in lung, spleen and pineal gland. Moderate expression in brain, kidney and testis.|||Phosphorylation on Thr-315 and Ser-316 may be crucial for rapid desensitization. Phosphorylation on Thr-315 may be necessary for phosphorylation on Ser-316 to occur.|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BBS9 ^@ http://purl.uniprot.org/uniprot/A0A6P3E438 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AARD ^@ http://purl.uniprot.org/uniprot/A0A6P3E7D0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101106131 ^@ http://purl.uniprot.org/uniprot/A0A8N7XJH5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 6A family.|||Membrane|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATP5F1C ^@ http://purl.uniprot.org/uniprot/A0A6P3EK28 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC105612644 ^@ http://purl.uniprot.org/uniprot/W5PB84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:HSD11B1 ^@ http://purl.uniprot.org/uniprot/P51975 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Controls the reversible conversion of biologically active glucocorticoids such as cortisone to cortisol, and 11-dehydrocorticosterone to corticosterone in the presence of NADP(H) (By similarity). Participates in the corticosteroid receptor-mediated anti-inflammatory response, as well as metabolic and homeostatic processes (By similarity). Plays a role in the secretion of aqueous humor in the eye, maintaining a normotensive, intraocular environment (By similarity). Bidirectional in vitro, predominantly functions as a reductase in vivo, thereby increasing the concentration of active glucocorticoids (By similarity). It has broad substrate specificity, besides glucocorticoids, it accepts other steroid and sterol substrates. Interconverts 7-oxo- and 7-hydroxy-neurosteroids such as 7-oxopregnenolone and 7beta-hydroxypregnenolone, 7-oxodehydroepiandrosterone (3beta-hydroxy-5-androstene-7,17-dione) and 7beta-hydroxydehydroepiandrosterone (3beta,7beta-dihydroxyandrost-5-en-17-one), among others (By similarity). Catalyzes the stereo-specific conversion of the major dietary oxysterol, 7-ketocholesterol (7-oxocholesterol), into the more polar 7-beta-hydroxycholesterol metabolite (By similarity). 7-oxocholesterol is one of the most important oxysterols, it participates in several events such as induction of apoptosis, accumulation in atherosclerotic lesions, lipid peroxidation, and induction of foam cell formation (By similarity). Mediates the 7-oxo reduction of 7-oxolithocholate mainly to chenodeoxycholate, and to a lesser extent to ursodeoxycholate, both in its free form and when conjugated to glycine or taurine, providing a link between glucocorticoid activation and bile acid metabolism (By similarity). Catalyzes the synthesis of 7-beta-25-dihydroxycholesterol from 7-oxo-25-hydroxycholesterol in vitro, which acts as ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (By similarity).|||Endoplasmic reticulum membrane|||Expression in the liver during fetal development increases between day 125 and term, and rises further in the newborn, being highest in the adult liver.|||Homodimer.|||Liver, kidney, lung, hypothalamus, anterior pituitary and placenta. http://togogenome.org/gene/9940:ETFRF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TF54 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9940:KLHL10 ^@ http://purl.uniprot.org/uniprot/A0A6P3EIV1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM251 ^@ http://purl.uniprot.org/uniprot/A0A6P3TB47|||http://purl.uniprot.org/uniprot/W5PVH4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM251 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SSTR1 ^@ http://purl.uniprot.org/uniprot/W5Q7Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:OPN1SW ^@ http://purl.uniprot.org/uniprot/W5NYP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane|||Photoreceptor inner segment|||photoreceptor outer segment http://togogenome.org/gene/9940:LOC101112223 ^@ http://purl.uniprot.org/uniprot/W5Q2F4 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. http://togogenome.org/gene/9940:LBH ^@ http://purl.uniprot.org/uniprot/A0A6P3E2I3|||http://purl.uniprot.org/uniprot/W5QEE2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LBH family.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Transcriptional activator. http://togogenome.org/gene/9940:BOLA1 ^@ http://purl.uniprot.org/uniprot/W5QHP1 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/9940:PROP1 ^@ http://purl.uniprot.org/uniprot/Q6QME2 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes. http://togogenome.org/gene/9940:DDAH1 ^@ http://purl.uniprot.org/uniprot/W5PY34 ^@ Function|||Similarity ^@ Belongs to the DDAH family.|||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. http://togogenome.org/gene/9940:TMEM147 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJL9 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Endoplasmic reticulum membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HOXA9 ^@ http://purl.uniprot.org/uniprot/A0A6P3ED29|||http://purl.uniprot.org/uniprot/W5PIW4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC105601870 ^@ http://purl.uniprot.org/uniprot/A0A836A8K7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101112606 ^@ http://purl.uniprot.org/uniprot/A0A836CVN3|||http://purl.uniprot.org/uniprot/W5QGB5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC443320 ^@ http://purl.uniprot.org/uniprot/P17607|||http://purl.uniprot.org/uniprot/R9QY43 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the glycosyl hydrolase 22 family.|||Expressed in stomach.|||Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.|||Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.|||Monomer.|||Secreted|||The sequence of isozyme 1A/1B/1C is shown. http://togogenome.org/gene/9940:SEC22B ^@ http://purl.uniprot.org/uniprot/A0A6P3E5M8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Melanosome|||Membrane|||SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/9940:FURIN ^@ http://purl.uniprot.org/uniprot/Q3BKJ1 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9940:TMEM100 ^@ http://purl.uniprot.org/uniprot/A0A836AB51 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101120617 ^@ http://purl.uniprot.org/uniprot/W5Q1B9 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9940:MRPS23 ^@ http://purl.uniprot.org/uniprot/W5PDS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS23 family.|||Mitochondrion http://togogenome.org/gene/9940:CTLA4 ^@ http://purl.uniprot.org/uniprot/O97631 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.|||Membrane http://togogenome.org/gene/9940:RPL27A ^@ http://purl.uniprot.org/uniprot/A0A6P3EHS7 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL15 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ORC6 ^@ http://purl.uniprot.org/uniprot/W5Q251 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC6 family.|||Nucleus http://togogenome.org/gene/9940:TNFSF18 ^@ http://purl.uniprot.org/uniprot/A0A6P3EI14 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101114173 ^@ http://purl.uniprot.org/uniprot/A0A836D750 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPP1CA ^@ http://purl.uniprot.org/uniprot/A0A6P3TD53|||http://purl.uniprot.org/uniprot/W5PNV2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9940:CFAP45 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4M1 ^@ Caution|||Similarity ^@ Belongs to the CFAP45 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LUM ^@ http://purl.uniprot.org/uniprot/A0A6P3EAC6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.|||Binds to laminin.|||extracellular matrix http://togogenome.org/gene/9940:MCCC2 ^@ http://purl.uniprot.org/uniprot/W5P5E2 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/9940:CENPC ^@ http://purl.uniprot.org/uniprot/W5PA54 ^@ Similarity ^@ Belongs to the CENP-C/MIF2 family. http://togogenome.org/gene/9940:PTP4A1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YMX4 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9940:NUP54 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5L9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:YIPF6 ^@ http://purl.uniprot.org/uniprot/A0A6P3ESG9|||http://purl.uniprot.org/uniprot/W5PZ76 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RFC3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9E3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRPL15 ^@ http://purl.uniprot.org/uniprot/W5PXD4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/9940:PSAT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E976 ^@ Caution|||Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.|||Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101117013 ^@ http://purl.uniprot.org/uniprot/W5NYL2 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9940:SLC2A5 ^@ http://purl.uniprot.org/uniprot/Q8WMN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake.|||sarcolemma http://togogenome.org/gene/9940:PLAC8 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE64 ^@ Caution|||Similarity ^@ Belongs to the cornifelin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDKN1C ^@ http://purl.uniprot.org/uniprot/B7U177 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/9940:ARL2 ^@ http://purl.uniprot.org/uniprot/C5IWU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/9940:IL17F ^@ http://purl.uniprot.org/uniprot/W5PXB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9940:SMCR8 ^@ http://purl.uniprot.org/uniprot/A0A6P3EH86 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:THUMPD3 ^@ http://purl.uniprot.org/uniprot/A0A835ZNI6 ^@ Caution|||Similarity ^@ Belongs to the methyltransferase superfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DPYSL2 ^@ http://purl.uniprot.org/uniprot/W5PJ56 ^@ Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1.|||Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. http://togogenome.org/gene/9940:HIGD1B ^@ http://purl.uniprot.org/uniprot/A0A6P3E878 ^@ Caution|||Subcellular Location Annotation ^@ Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HBP1 ^@ http://purl.uniprot.org/uniprot/W5P4R4 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. http://togogenome.org/gene/9940:PDRG1 ^@ http://purl.uniprot.org/uniprot/A0A836D0G6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.|||Cytoplasm|||May play a role in chaperone-mediated protein folding.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SGPL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3T696|||http://purl.uniprot.org/uniprot/A0A6P7DH80 ^@ Caution|||Similarity ^@ Belongs to the group II decarboxylase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LHX8 ^@ http://purl.uniprot.org/uniprot/A0A6P3YIT0 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CD79A ^@ http://purl.uniprot.org/uniprot/W5PEV0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9940:PAG6 ^@ http://purl.uniprot.org/uniprot/P83493 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the peptidase A1 family.|||Highly expressed in the placenta between day 60 and day 100 of gestation.|||Trophoblast and placental tissue. Produced specifically in the invasive binucleate cells of the placenta.|||extracellular space http://togogenome.org/gene/9940:XPA ^@ http://purl.uniprot.org/uniprot/A0A6P3E927|||http://purl.uniprot.org/uniprot/W5PNI2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the XPA family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ANXA4 ^@ http://purl.uniprot.org/uniprot/A0A836AK26 ^@ Caution|||Domain|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Zymogen granule membrane http://togogenome.org/gene/9940:ELMO1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TG06|||http://purl.uniprot.org/uniprot/A0A6P7E001 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POLL ^@ http://purl.uniprot.org/uniprot/W5Q4Y8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/9940:BSG ^@ http://purl.uniprot.org/uniprot/W5PG64 ^@ Subcellular Location Annotation ^@ Basolateral cell membrane|||Cell membrane|||Endoplasmic reticulum membrane|||Lateral cell membrane http://togogenome.org/gene/9940:RFTN2 ^@ http://purl.uniprot.org/uniprot/W5Q221 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:CLCN4 ^@ http://purl.uniprot.org/uniprot/A0A6P7DLA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/9940:ATP6V1G1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YJ22|||http://purl.uniprot.org/uniprot/W5P7L2 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9940:ANAPC13 ^@ http://purl.uniprot.org/uniprot/A0A6P3E596|||http://purl.uniprot.org/uniprot/A0A6P3E8F7 ^@ Caution|||Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ANXA2 ^@ http://purl.uniprot.org/uniprot/A0A836D1K4|||http://purl.uniprot.org/uniprot/A2SW69 ^@ Caution|||Domain|||Function|||Induction|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.|||Detected in myometrium.|||Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36 (PubMed:17446234). Interacts with ATP1B1 (By similarity). Interacts with DYSF (By similarity). Interacts with COCH. Interacts (via repeat Annexin 1) with PCSK9 (via the C-terminal domain); the interaction inhibits the degradation of LDLR. Interacts with CEACAM1 (via the cytoplasmic domain); this interaction is regulated by phosphorylation of CEACAM1 (By similarity). Interacts with APPL2 and APPL1; targets APPL2 to endosomes and acting in parallel to RAB5A (By similarity). Interacts with S100A4 (By similarity). May interact with UBAP2 (By similarity). May interact with UBAP2 (By similarity).|||ISGylated.|||It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Up-regulated in myometrium upon progesterone treatment.|||basement membrane http://togogenome.org/gene/9940:EIF4B ^@ http://purl.uniprot.org/uniprot/A0A6P3E2S0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STXBP5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6Z6|||http://purl.uniprot.org/uniprot/W5NWF2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101119740 ^@ http://purl.uniprot.org/uniprot/W5PBY0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:MRPL51 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3I2|||http://purl.uniprot.org/uniprot/W5PE98 ^@ Caution|||Similarity ^@ Belongs to the mitochondrion-specific ribosomal protein mL51 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NDUFS4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB56 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS4 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101121607 ^@ http://purl.uniprot.org/uniprot/A0A6P3E807|||http://purl.uniprot.org/uniprot/W5QJ77 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COX16 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HESX1 ^@ http://purl.uniprot.org/uniprot/W5PZ12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANF homeobox family.|||Nucleus http://togogenome.org/gene/9940:POU2F1 ^@ http://purl.uniprot.org/uniprot/W5PR00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-2 subfamily.|||Nucleus|||Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. http://togogenome.org/gene/9940:KLHL5 ^@ http://purl.uniprot.org/uniprot/A0A6P3EF15 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SF3B1 ^@ http://purl.uniprot.org/uniprot/W5Q1B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B1 family.|||Nucleus http://togogenome.org/gene/9940:RTL8C ^@ http://purl.uniprot.org/uniprot/A0A835ZL83 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PCLAF ^@ http://purl.uniprot.org/uniprot/A0A6P3EG06 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||perinuclear region http://togogenome.org/gene/9940:TNFSF15 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7P5 ^@ Caution|||Similarity ^@ Belongs to the tumor necrosis factor family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ADAMTS4 ^@ http://purl.uniprot.org/uniprot/W5PIW9 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9940:DPY19L1 ^@ http://purl.uniprot.org/uniprot/W5P6T1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/9940:PI4K2A ^@ http://purl.uniprot.org/uniprot/A0A6P3EKQ8|||http://purl.uniprot.org/uniprot/W5PN65 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MARK3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EED7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||dendrite http://togogenome.org/gene/9940:LOC101110478 ^@ http://purl.uniprot.org/uniprot/A0A6P3TGG7|||http://purl.uniprot.org/uniprot/A0A6P3TIG5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SOSS-C family.|||Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).|||Component of the SOSS complex.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PHB ^@ http://purl.uniprot.org/uniprot/A0A6P3EHB3|||http://purl.uniprot.org/uniprot/A0A6P3TWZ1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Cell membrane|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC35A5 ^@ http://purl.uniprot.org/uniprot/A0A6P3TNI5|||http://purl.uniprot.org/uniprot/W5QDG6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRIM45 ^@ http://purl.uniprot.org/uniprot/W5QGE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/9940:GOLPH3 ^@ http://purl.uniprot.org/uniprot/W5PRW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9940:RASL12 ^@ http://purl.uniprot.org/uniprot/A0A6P3YIL7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC27A6 ^@ http://purl.uniprot.org/uniprot/W5Q6G3 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9940:BPIFA1 ^@ http://purl.uniprot.org/uniprot/A0A075W0S2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. Plunc family.|||Monomer. Interacts (via N-terminus) with SCNN1B, a subunit of the heterotrimeric epithelial sodium channel (ENaC); this inhibits proteolytic activation of ENaC.|||Secreted http://togogenome.org/gene/9940:CPA1 ^@ http://purl.uniprot.org/uniprot/W5P5N4 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9940:PIP4K2B ^@ http://purl.uniprot.org/uniprot/A0A6P3EA99 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPL7L1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECJ2|||http://purl.uniprot.org/uniprot/W5P205 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL30 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SYNPR ^@ http://purl.uniprot.org/uniprot/W5PPT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/9940:LOC101110289 ^@ http://purl.uniprot.org/uniprot/A0A6P3E0E6|||http://purl.uniprot.org/uniprot/W5NY57 ^@ Caution|||Similarity ^@ Belongs to the ARTD/PARP family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NPPC ^@ http://purl.uniprot.org/uniprot/P56283 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Degraded by IDE (in vitro).|||Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity). May also be vasoactive and natriuretic. Acts by specifically binding and stimulating NPR2 to produce cGMP. Binds the clearance receptor NPR3 (By similarity).|||Secreted http://togogenome.org/gene/9940:TMEM267 ^@ http://purl.uniprot.org/uniprot/W5PFQ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:RP2 ^@ http://purl.uniprot.org/uniprot/W5PX03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.|||Belongs to the TBCC family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:HS3ST1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E737|||http://purl.uniprot.org/uniprot/A0A6P7E786 ^@ Caution|||Similarity ^@ Belongs to the sulfotransferase 1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FTL ^@ http://purl.uniprot.org/uniprot/A0A6P3ECH0|||http://purl.uniprot.org/uniprot/W5PA59 ^@ Caution|||Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STAM ^@ http://purl.uniprot.org/uniprot/A0A6P3EBL1|||http://purl.uniprot.org/uniprot/W5PPV5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GABARAPL2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YQB0 ^@ Caution|||Similarity ^@ Belongs to the ATG8 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DNAJC10 ^@ http://purl.uniprot.org/uniprot/W5Q5P0 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9940:SCN2A ^@ http://purl.uniprot.org/uniprot/W5P5U3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9940:MMP16 ^@ http://purl.uniprot.org/uniprot/W5PNX8 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9940:SV2B ^@ http://purl.uniprot.org/uniprot/A0A6P3T2A6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||synaptic vesicle membrane http://togogenome.org/gene/9940:TMEM50B ^@ http://purl.uniprot.org/uniprot/A0A6P3E7K3|||http://purl.uniprot.org/uniprot/A0A6P3YFB1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101107119 ^@ http://purl.uniprot.org/uniprot/W5PHN8 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9940:LOC101116381 ^@ http://purl.uniprot.org/uniprot/A0A6P3YUF4 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/9940:LOC101114033 ^@ http://purl.uniprot.org/uniprot/A0A835ZJ51|||http://purl.uniprot.org/uniprot/K4P217 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL22 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ELOVL1 ^@ http://purl.uniprot.org/uniprot/W5QH76 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family. ELOVL1 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.|||Endoplasmic reticulum membrane|||Interacts with LASS2, TECR and HSD17B12.|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9940:SULT2B1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9X1|||http://purl.uniprot.org/uniprot/W5PQK8 ^@ Caution|||Similarity ^@ Belongs to the sulfotransferase 1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BLM ^@ http://purl.uniprot.org/uniprot/W5PTL9 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/9940:NDUFA13 ^@ http://purl.uniprot.org/uniprot/A0A6P3E975 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I NDUFA13 subunit family.|||Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.|||Mitochondrion inner membrane http://togogenome.org/gene/9940:INPP5K ^@ http://purl.uniprot.org/uniprot/A0A6P3TRE5 ^@ Caution|||Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MIS12 ^@ http://purl.uniprot.org/uniprot/W5P2A8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mis12 family.|||Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.|||kinetochore http://togogenome.org/gene/9940:NMNAT3 ^@ http://purl.uniprot.org/uniprot/W5PAI8 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9940:GYPC ^@ http://purl.uniprot.org/uniprot/A0A6P3E9W4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GRWD1 ^@ http://purl.uniprot.org/uniprot/W5PQ74 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:LOC101118279 ^@ http://purl.uniprot.org/uniprot/A0A6P3TU94 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC30A4 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6A5|||http://purl.uniprot.org/uniprot/W5QIR1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IL10 ^@ http://purl.uniprot.org/uniprot/Q29408 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-10 family.|||Homodimer. Interacts with IL10RA and IL10RB.|||Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).|||Secreted http://togogenome.org/gene/9940:LOC101123533 ^@ http://purl.uniprot.org/uniprot/A0A6P7D695|||http://purl.uniprot.org/uniprot/A0A6P7DQI8 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SPTSSB ^@ http://purl.uniprot.org/uniprot/A0A6P3E887|||http://purl.uniprot.org/uniprot/W5PZT5 ^@ Caution|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:APOBEC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TFD5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC35B1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDB7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TPM2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E0T4|||http://purl.uniprot.org/uniprot/W5PQL4|||http://purl.uniprot.org/uniprot/W5PQL7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytoskeleton http://togogenome.org/gene/9940:ITGAL ^@ http://purl.uniprot.org/uniprot/Q4QWZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9940:ASF1B ^@ http://purl.uniprot.org/uniprot/A0A6P3ECG8|||http://purl.uniprot.org/uniprot/W5P8R6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLEC3A ^@ http://purl.uniprot.org/uniprot/A0A6P3EKW7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TAC3 ^@ http://purl.uniprot.org/uniprot/W5PDI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted http://togogenome.org/gene/9940:BMPR1B ^@ http://purl.uniprot.org/uniprot/Q9BDI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9940:ODF1 ^@ http://purl.uniprot.org/uniprot/W5Q6T4 ^@ Function ^@ Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. http://togogenome.org/gene/9940:RNF167 ^@ http://purl.uniprot.org/uniprot/A0A6P3ED25|||http://purl.uniprot.org/uniprot/A0A6P7EI20 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UCP2 ^@ http://purl.uniprot.org/uniprot/M4SYY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9940:STEAP4 ^@ http://purl.uniprot.org/uniprot/W5PQD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9940:PANX1 ^@ http://purl.uniprot.org/uniprot/W5NUS9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||S-nitrosylation inhibits channel currents and ATP release.|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/9940:NPVF ^@ http://purl.uniprot.org/uniprot/B2KKR4 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the FARP (FMRFamide related peptide) family.|||Expressed in hypothalamus, where it is localized to the dorsomedial hypothalamic nucleus (DMH), paraventricular nucleus (PVN), and to neuronal projections from the PVN to the neurosecretory zone of the median eminence.|||Expression moderately increased by a longer photoperiod.|||Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide NPVF blocks morphine-induced analgesia (By similarity). May act in concert with kisspeptin, through opposing affects, to regulate the activity of gonadotropin-releasing hormone (GnRH) neurons across the seasons, leading to an annual change in fertility and the cyclical seasonal transition from non-breeding to breeding season.|||Secreted http://togogenome.org/gene/9940:PNRC2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9D2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PNRC family. PNRC2 subfamily.|||Nucleus|||P-body|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GCNT4 ^@ http://purl.uniprot.org/uniprot/A0A6P3YJX5|||http://purl.uniprot.org/uniprot/W5PPM1 ^@ Caution|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GIMD1 ^@ http://purl.uniprot.org/uniprot/W5PGZ7 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9940:TRIM21 ^@ http://purl.uniprot.org/uniprot/A0A836A1R3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FMO2 ^@ http://purl.uniprot.org/uniprot/W5PS98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9940:CCNL2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB75 ^@ Caution|||Similarity ^@ Belongs to the cyclin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AQP2 ^@ http://purl.uniprot.org/uniprot/A0A836D3U5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TSNAXIP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TK93 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRDM4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB12|||http://purl.uniprot.org/uniprot/W5Q982 ^@ Caution|||Function|||Subcellular Location Annotation ^@ May function as a transcription factor involved in cell differentiation.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TAF9B ^@ http://purl.uniprot.org/uniprot/A0A6P3EHD9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101110195 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7S3|||http://purl.uniprot.org/uniprot/W5Q9G3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAM168B ^@ http://purl.uniprot.org/uniprot/A0A6P3YJC7 ^@ Caution|||Similarity ^@ Belongs to the FAM168 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NAMPT ^@ http://purl.uniprot.org/uniprot/A0A6P3E4P7|||http://purl.uniprot.org/uniprot/W5P316 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAPRTase family.|||Cytoplasm|||Homodimer.|||Nucleus|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRPL23 ^@ http://purl.uniprot.org/uniprot/W5NRD3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9940:RAB19 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDA8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NOL10 ^@ http://purl.uniprot.org/uniprot/W5Q1Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat NOL10/ENP2 family.|||nucleolus http://togogenome.org/gene/9940:POMGNT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YEX3|||http://purl.uniprot.org/uniprot/W5NW01 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Membrane|||Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.|||The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein. http://togogenome.org/gene/9940:EXOSC3 ^@ http://purl.uniprot.org/uniprot/A0A836AA42|||http://purl.uniprot.org/uniprot/W5PP23 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP40 family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLRN1 ^@ http://purl.uniprot.org/uniprot/W5P2C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9940:KCNMB4 ^@ http://purl.uniprot.org/uniprot/W5QG40 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9940:TASL ^@ http://purl.uniprot.org/uniprot/A0A6P3TFF0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC100147796 ^@ http://purl.uniprot.org/uniprot/B2MVX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9940:FAN1 ^@ http://purl.uniprot.org/uniprot/W5Q3J7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAN1 family.|||Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.|||Nucleus http://togogenome.org/gene/9940:RNF141 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECW5|||http://purl.uniprot.org/uniprot/A0A6P7EVQ2 ^@ Caution|||Function ^@ May be involved in spermatogenesis.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101119670 ^@ http://purl.uniprot.org/uniprot/W5PB51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:ZRANB2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6K0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZRANB2 family.|||Nucleus|||Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection. http://togogenome.org/gene/9940:LOC101102156 ^@ http://purl.uniprot.org/uniprot/A0A835ZZQ9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DDX23 ^@ http://purl.uniprot.org/uniprot/A0A836AA30 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RAD17 ^@ http://purl.uniprot.org/uniprot/W5P6J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad17/RAD24 family.|||Nucleus http://togogenome.org/gene/9940:ARL6IP6 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9U4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SCARA5 ^@ http://purl.uniprot.org/uniprot/W5PZR9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCARA5 family.|||Cell membrane|||Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).|||Homotrimer.|||Membrane http://togogenome.org/gene/9940:TRIB2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9Q0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IL25 ^@ http://purl.uniprot.org/uniprot/A0A6P3TNJ3|||http://purl.uniprot.org/uniprot/E1XUM4|||http://purl.uniprot.org/uniprot/E1XUM5 ^@ Caution|||Similarity ^@ Belongs to the IL-17 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C1GALT1 ^@ http://purl.uniprot.org/uniprot/W5P439 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.|||Membrane http://togogenome.org/gene/9940:PCSK1 ^@ http://purl.uniprot.org/uniprot/W5Q845 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.|||Vesicle|||secretory vesicle http://togogenome.org/gene/9940:LOC101117508 ^@ http://purl.uniprot.org/uniprot/W5PW28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:OTOR ^@ http://purl.uniprot.org/uniprot/A0A6P3EK22 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRPL17 ^@ http://purl.uniprot.org/uniprot/W5Q518 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL17 family. http://togogenome.org/gene/9940:SNX10 ^@ http://purl.uniprot.org/uniprot/A0A6P3E453|||http://purl.uniprot.org/uniprot/A0A6P7E1F4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC7A6 ^@ http://purl.uniprot.org/uniprot/A0A836A3C0|||http://purl.uniprot.org/uniprot/W5NZM1 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TTC26 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC63|||http://purl.uniprot.org/uniprot/W5PNF9 ^@ Caution|||Similarity ^@ Belongs to the IFT56 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NR1D1 ^@ http://purl.uniprot.org/uniprot/B3SV56 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Binds DNA as a monomer or a homodimer (By similarity). Interacts with C1D, NR2E3, SP1 and ZNHIT1 (By similarity). Interacts with OPHN1 (via C-terminus) (By similarity). Interacts with PER2; the interaction associates PER2 to BMAL1 promoter region (By similarity). Interacts with CRY1 (By similarity). Interacts with CCAR2 (By similarity). Interacts with SIAH2 (By similarity). Interacts with FBXW7 and CDK1 (By similarity). Interacts with HUWE1 (By similarity). Interacts with NR0B2 (By similarity). Interacts with NFIL3 (By similarity). Interacts (via domain NR LBD) with HSP90AA1 and HSP90AB1 (By similarity).|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Cytoplasm|||Expressed in all tissues and cell lines examined. Expressed at high levels in some squamous carcinoma cell lines.|||Nucleus|||Phosphorylated by CSNK1E; phosphorylation enhances its cytoplasmic localization.|||Sumoylated by UBE2I, desumoylated by SENP1, and sumoylation is a prerequisite to its ubiquitination.|||Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner (By similarity). Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity). Represses the transcription of CES2 (By similarity). Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity). Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity). Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity). Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity). Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity).|||Ubiquitinated, leading to its proteasomal degradation (By similarity). Ubiquitinated by the SCF(FBXW7) complex when phosphorylated by CDK1 leading to its proteasomal degradation (By similarity). Ubiquitinated by SIAH2; leading to its proteasomal degradation (By similarity). Rapidly ubiquitinated in response to inflammatory triggers and sumoylation is a prerequisite to its ubiquitination (By similarity).|||Undergoes lysosome-mediated degradation in a time-dependent manner in the liver.|||dendrite|||dendritic spine http://togogenome.org/gene/9940:C26H4orf47 ^@ http://purl.uniprot.org/uniprot/A0A6P3ERJ9|||http://purl.uniprot.org/uniprot/W5PDB3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0602 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||centrosome http://togogenome.org/gene/9940:BSP5 ^@ http://purl.uniprot.org/uniprot/A4GZY3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:NAPB ^@ http://purl.uniprot.org/uniprot/W5P625 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9940:ZFP69 ^@ http://purl.uniprot.org/uniprot/W5QGA6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:LOC101117534 ^@ http://purl.uniprot.org/uniprot/W5P8W9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:LOC101110888 ^@ http://purl.uniprot.org/uniprot/W5PX16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIP family.|||adherens junction|||centriolar satellite http://togogenome.org/gene/9940:PMVK ^@ http://purl.uniprot.org/uniprot/W5NYK1 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/9940:RNF11 ^@ http://purl.uniprot.org/uniprot/A0A6P3DY87 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRMT13 ^@ http://purl.uniprot.org/uniprot/W5Q9B4 ^@ Function|||Similarity ^@ Belongs to the methyltransferase TRM13 family.|||tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). http://togogenome.org/gene/9940:TARBP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7K6|||http://purl.uniprot.org/uniprot/W5Q4L1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TARBP2 family.|||Cytoplasm|||Nucleus|||Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.|||Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||perinuclear region http://togogenome.org/gene/9940:CA3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YN32|||http://purl.uniprot.org/uniprot/W5PUC1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-carbonic anhydrase family.|||Cytoplasm|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9940:KDM5C ^@ http://purl.uniprot.org/uniprot/A0A6P3THL4|||http://purl.uniprot.org/uniprot/W5PGP0 ^@ Caution|||Similarity ^@ Belongs to the JARID1 histone demethylase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FBXO32 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8Y7|||http://purl.uniprot.org/uniprot/W5PJS7 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RUNDC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E869 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:COPS2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7V1|||http://purl.uniprot.org/uniprot/W5QIM2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN2 family.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PSMB2 ^@ http://purl.uniprot.org/uniprot/A0A6P3DYK1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101115331 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4C1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Golgi pH regulator (TC 1.A.38) family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PARP9 ^@ http://purl.uniprot.org/uniprot/W5QFY8 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9940:C15H11orf52 ^@ http://purl.uniprot.org/uniprot/A0A6P3T4R9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RBM3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EH89 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLITRK6 ^@ http://purl.uniprot.org/uniprot/W5Q6T2 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9940:MYOZ3 ^@ http://purl.uniprot.org/uniprot/E5FXR6 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9940:LAMTOR3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEX7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.|||Belongs to the LAMTOR3 family.|||Endosome membrane|||Late endosome membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PYGM ^@ http://purl.uniprot.org/uniprot/A0A835ZTN9|||http://purl.uniprot.org/uniprot/O18751 ^@ Activity Regulation|||Caution|||Function|||PTM|||Similarity|||Subunit ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Allosterically regulated through the non-covalent binding of metabolites, being activated by AMP and inhibited by ATP, ADP, and glucose-6-phosphate. The activity is also controlled by post-translational modifications including phosphorylation.|||Belongs to the glycogen phosphorylase family.|||Homodimer. Homotetramer; to form the enzymatically active phosphorylase A.|||Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAU ^@ http://purl.uniprot.org/uniprot/A0A6P3EK71 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CSN2 ^@ http://purl.uniprot.org/uniprot/P11839 ^@ Function|||Polymorphism|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the beta-casein family.|||Important role in determination of the surface properties of the casein micelles.|||Mammary gland specific. Secreted in milk.|||Secreted|||The frequency of variant Val-198 is 0.237, 0.244 and 0.176 in Italian breeds Comisana, Sarda and Sopravissana, respectively. http://togogenome.org/gene/9940:LRRC8C ^@ http://purl.uniprot.org/uniprot/W5Q1X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:LOC101111610 ^@ http://purl.uniprot.org/uniprot/A0A6P3YPM2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PAG1 ^@ http://purl.uniprot.org/uniprot/A0A835ZYX1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRSS23 ^@ http://purl.uniprot.org/uniprot/A0A835ZME5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:COQ9 ^@ http://purl.uniprot.org/uniprot/W5NPZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COQ9 family.|||Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.|||Mitochondrion http://togogenome.org/gene/9940:LOC101120285 ^@ http://purl.uniprot.org/uniprot/A0A836CR39 ^@ Caution|||Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101115389 ^@ http://purl.uniprot.org/uniprot/W5PQI4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9940:LOC101119393 ^@ http://purl.uniprot.org/uniprot/A0A836AAU3|||http://purl.uniprot.org/uniprot/W5PIZ0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM225B ^@ http://purl.uniprot.org/uniprot/A0A6P3EGJ5|||http://purl.uniprot.org/uniprot/A0A6P3TEK7 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PSMB3 ^@ http://purl.uniprot.org/uniprot/W5PJC2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9940:RPL13A ^@ http://purl.uniprot.org/uniprot/A0A6P3TW05 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL13 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101107153 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/9940:PRKAR1A ^@ http://purl.uniprot.org/uniprot/A0A6P3CX84|||http://purl.uniprot.org/uniprot/A0A6P7EEY4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FMR1NB ^@ http://purl.uniprot.org/uniprot/A0A6P3ESL4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AHCY ^@ http://purl.uniprot.org/uniprot/A0A6P3EBV9|||http://purl.uniprot.org/uniprot/W5PHX1 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC26A4 ^@ http://purl.uniprot.org/uniprot/A0A836D2B9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Cell membrane|||Membrane|||Sodium-independent transporter of chloride and iodide.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HMGB2 ^@ http://purl.uniprot.org/uniprot/W5Q1B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9940:LOC101112339 ^@ http://purl.uniprot.org/uniprot/A0A836A542|||http://purl.uniprot.org/uniprot/W5P2W9 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||Component of the 40S ribosomal subunit.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CBX5 ^@ http://purl.uniprot.org/uniprot/A0A6P3TDF3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EPS8 ^@ http://purl.uniprot.org/uniprot/W5QHG1 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/9940:CALB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECF0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the calbindin family.|||Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.|||Interacts with RANBP9.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FOXR2 ^@ http://purl.uniprot.org/uniprot/W5P6A9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:PHYHIPL ^@ http://purl.uniprot.org/uniprot/W5P1X6 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/9940:LOC101122444 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGA1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101108811 ^@ http://purl.uniprot.org/uniprot/W5QDY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:RAB9B ^@ http://purl.uniprot.org/uniprot/W5PJT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/9940:CALB2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EL68|||http://purl.uniprot.org/uniprot/W5P1A7 ^@ Caution|||Function|||Similarity ^@ Belongs to the calbindin family.|||Calretinin is a calcium-binding protein which is abundant in auditory neurons.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CRYBB3 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQB5|||http://purl.uniprot.org/uniprot/Q52NW3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:VIPAS39 ^@ http://purl.uniprot.org/uniprot/A0A836D0N5 ^@ Caution|||Subcellular Location Annotation ^@ Early endosome|||Endosome|||Late endosome|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Vesicle http://togogenome.org/gene/9940:DGAT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3CWQ9|||http://purl.uniprot.org/uniprot/A8VJM4 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Homodimer or homotetramer; both forms have similar enzymatic activities.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CHRNB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7V7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101109397 ^@ http://purl.uniprot.org/uniprot/W5QFP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9940:LOC101103916 ^@ http://purl.uniprot.org/uniprot/A0A6P3YLD4|||http://purl.uniprot.org/uniprot/W5NV66 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PGLYRP2 ^@ http://purl.uniprot.org/uniprot/A0A836D1F9|||http://purl.uniprot.org/uniprot/W5NYF4 ^@ Caution|||Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDK7 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDL7 ^@ Caution|||Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LRRC8B ^@ http://purl.uniprot.org/uniprot/W5Q1V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:YTHDC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TPX4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POLD3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAH5|||http://purl.uniprot.org/uniprot/W5PKJ6 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM265 ^@ http://purl.uniprot.org/uniprot/A0A6P3CYD5 ^@ Caution|||Similarity ^@ Belongs to the CD225/Dispanin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MEF2C ^@ http://purl.uniprot.org/uniprot/C0LU83 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:TRIM38 ^@ http://purl.uniprot.org/uniprot/A0A6P3T846 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPIB ^@ http://purl.uniprot.org/uniprot/A0A6P3EF09|||http://purl.uniprot.org/uniprot/W5QHU9 ^@ Caution|||Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPIL3 ^@ http://purl.uniprot.org/uniprot/A0A6P3CXJ6 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9940:NCOA2 ^@ http://purl.uniprot.org/uniprot/W5P0T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/9940:OVAR ^@ http://purl.uniprot.org/uniprot/A4ZVZ3 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9940:MTRF1L ^@ http://purl.uniprot.org/uniprot/W5P1H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/9940:LACTB2 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECA3 ^@ Caution|||Function|||Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101122891 ^@ http://purl.uniprot.org/uniprot/W5PYB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCHP family.|||cytoskeleton http://togogenome.org/gene/9940:PAMR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EML3|||http://purl.uniprot.org/uniprot/W5QC79 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM81 ^@ http://purl.uniprot.org/uniprot/A0A836A888 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101120610 ^@ http://purl.uniprot.org/uniprot/A0A835ZQH6 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FXR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3T288|||http://purl.uniprot.org/uniprot/W5QHL9 ^@ Caution|||Similarity ^@ Belongs to the FMR1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PROCA1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9S1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PCCA ^@ http://purl.uniprot.org/uniprot/A0A836AAQ5 ^@ Caution|||Subcellular Location Annotation ^@ Mitochondrion matrix|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PSMC4 ^@ http://purl.uniprot.org/uniprot/W5P8Z3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.|||Cytoplasm http://togogenome.org/gene/9940:SRP54 ^@ http://purl.uniprot.org/uniprot/A0A6P3TB01|||http://purl.uniprot.org/uniprot/A0A6P3TDG1 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.|||Cytoplasm|||Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.|||Nucleus speckle|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMPRSS4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EM03|||http://purl.uniprot.org/uniprot/W5PDH0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RRN3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE45 ^@ Caution|||Similarity ^@ Belongs to the RRN3 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDCA7L ^@ http://purl.uniprot.org/uniprot/A0A6P3TFS4 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PTBP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECV0|||http://purl.uniprot.org/uniprot/W5PI44 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101107644 ^@ http://purl.uniprot.org/uniprot/A0A835ZMQ7|||http://purl.uniprot.org/uniprot/W5P726 ^@ Caution|||Similarity ^@ Belongs to the peptidase S28 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDK1 ^@ http://purl.uniprot.org/uniprot/A0A6P3CX96|||http://purl.uniprot.org/uniprot/B7U175 ^@ Caution|||Similarity ^@ Belongs to the protein kinase superfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RRM1 ^@ http://purl.uniprot.org/uniprot/W5NT70 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/9940:RAB3A ^@ http://purl.uniprot.org/uniprot/B2MVW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9940:LOC101109545 ^@ http://purl.uniprot.org/uniprot/W5QFZ8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/9940:FOXB1 ^@ http://purl.uniprot.org/uniprot/W5NRY5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:CXCR4 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQV1|||http://purl.uniprot.org/uniprot/W5PLA4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell junction|||Cell membrane|||Early endosome|||Endosome|||Late endosome|||Lysosome|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CHM ^@ http://purl.uniprot.org/uniprot/A0A6P3ESK5|||http://purl.uniprot.org/uniprot/W5NX57 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAM32A ^@ http://purl.uniprot.org/uniprot/A0A6P3E4F6|||http://purl.uniprot.org/uniprot/W5NQ52 ^@ Caution|||Similarity ^@ Belongs to the FAM32 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ELOVL6 ^@ http://purl.uniprot.org/uniprot/W5P2I0 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL6 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-Glycosylated. http://togogenome.org/gene/9940:LOC101108787 ^@ http://purl.uniprot.org/uniprot/A0A6P3DYJ8|||http://purl.uniprot.org/uniprot/A0A6P3TRA7 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TOE1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TIZ1|||http://purl.uniprot.org/uniprot/W5NTY9 ^@ Caution|||Similarity ^@ Belongs to the CAF1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MX1 ^@ http://purl.uniprot.org/uniprot/P33237 ^@ Domain|||Function|||Induction|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.|||By type I and type III interferons.|||Cytoplasm|||Endoplasmic reticulum membrane|||Homooligomer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures (By similarity). Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7 (By similarity). Interacts with HSPA5 (By similarity). Interacts with DDX39A and DDX39B (By similarity). Interacts with TUBB/TUBB5.|||ISGylated.|||Interferon-induced dynamin-like GTPase with antiviral activity.|||The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.|||The middle domain mediates self-assembly and oligomerization.|||perinuclear region http://togogenome.org/gene/9940:GET3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E998|||http://purl.uniprot.org/uniprot/W5PP30 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.|||Belongs to the arsA ATPase family.|||Cytoplasm|||Endoplasmic reticulum|||Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:PCK2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YMI7 ^@ Caution|||Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARL11 ^@ http://purl.uniprot.org/uniprot/A0A6P3TVY6 ^@ Caution|||Similarity ^@ Belongs to the small GTPase superfamily. Arf family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101105383 ^@ http://purl.uniprot.org/uniprot/A0A6P3TA70|||http://purl.uniprot.org/uniprot/A0A6P7EGA1 ^@ Caution|||Similarity ^@ Belongs to the peptidase C12 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLDN7 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQR4|||http://purl.uniprot.org/uniprot/D6R7I9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||tight junction http://togogenome.org/gene/9940:FAM221A ^@ http://purl.uniprot.org/uniprot/A0A6P3TL98 ^@ Caution|||Similarity ^@ Belongs to the FAM221 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NSUN3 ^@ http://purl.uniprot.org/uniprot/W5Q7D1 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9940:MTIF3 ^@ http://purl.uniprot.org/uniprot/A0A6P7EG41 ^@ Similarity ^@ Belongs to the IF-3 family. http://togogenome.org/gene/9940:SPINK1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE96 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GTF2A1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGG0|||http://purl.uniprot.org/uniprot/W5NY55 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ERMP1 ^@ http://purl.uniprot.org/uniprot/A0A836AMB2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CUBN ^@ http://purl.uniprot.org/uniprot/W5PJU0 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9940:DGUOK ^@ http://purl.uniprot.org/uniprot/W5PRH4 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9940:LOC101106720 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEW7 ^@ Caution|||Similarity ^@ Belongs to the GST superfamily. Alpha family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:VPS53 ^@ http://purl.uniprot.org/uniprot/A0A6P3TWM0|||http://purl.uniprot.org/uniprot/W5PQ22 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS53 family.|||Endosome membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||trans-Golgi network membrane http://togogenome.org/gene/9940:FAM126A ^@ http://purl.uniprot.org/uniprot/A0A6P3TCS1|||http://purl.uniprot.org/uniprot/W5PRJ3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM126 family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytosol http://togogenome.org/gene/9940:PIFO ^@ http://purl.uniprot.org/uniprot/A0A6P3DZ97 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PDSS2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFU0 ^@ Caution|||Similarity ^@ Belongs to the FPP/GGPP synthase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZNF3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEB3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC443319 ^@ http://purl.uniprot.org/uniprot/P16038 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/9940:NMS ^@ http://purl.uniprot.org/uniprot/W5PUY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NmU family.|||Secreted http://togogenome.org/gene/9940:FABP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E568|||http://purl.uniprot.org/uniprot/W5Q4A5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm|||FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:XRCC5 ^@ http://purl.uniprot.org/uniprot/A0A836D6X1|||http://purl.uniprot.org/uniprot/W5QDK7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ku80 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TACR1 ^@ http://purl.uniprot.org/uniprot/W5PTQ9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane http://togogenome.org/gene/9940:CRYAB ^@ http://purl.uniprot.org/uniprot/Q5ENY9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small heat shock protein (HSP20) family.|||Cytoplasm|||Heteromer composed of three CRYAA and one CRYAB subunits. Aggregates with homologous proteins, including the small heat shock protein HSPB1, to form large heteromeric complexes. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Interacts with HSPBAP1 and TTN/titin. Interacts with TMEM109. Interacts with DES; binds rapidly during early stages of DES filament assembly and a reduced binding seen in the later stages. Interacts with ATP6V1A and with MTOR, forming a ternary complex (By similarity).|||Lysosome|||May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity).|||Nucleus|||Secreted http://togogenome.org/gene/9940:ARL4D ^@ http://purl.uniprot.org/uniprot/A0A6P3E873|||http://purl.uniprot.org/uniprot/A0A6P7EGF2 ^@ Caution|||Similarity ^@ Belongs to the small GTPase superfamily. Arf family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ALDH1A1 ^@ http://purl.uniprot.org/uniprot/A0A836AM83|||http://purl.uniprot.org/uniprot/P51977 ^@ Activity Regulation|||Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:26373694). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification. Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity). Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity).|||Homotetramer (PubMed:26373694, PubMed:9862807). Interacts with PRMT3; the interaction is direct, inhibits ALDH1A1 aldehyde dehydrogenase activity and is independent of the methyltransferase activity of PRMT3 (By similarity).|||Inhibited by duocarmycin analogs.|||The N-terminus is blocked most probably by acetylation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||axon|||cytosol http://togogenome.org/gene/9940:ABHD2 ^@ http://purl.uniprot.org/uniprot/W5PNS1 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/9940:LOC101121993 ^@ http://purl.uniprot.org/uniprot/A0A6P3E0G2|||http://purl.uniprot.org/uniprot/W5P4H3 ^@ Caution|||Similarity ^@ Belongs to the multicopper oxidase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EMC3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EPB8 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZDHHC4 ^@ http://purl.uniprot.org/uniprot/A0A6P3ER36|||http://purl.uniprot.org/uniprot/A0A6P3T615 ^@ Caution|||Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PDK2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EA71 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HNRNPAB ^@ http://purl.uniprot.org/uniprot/A0A6P3E9H9|||http://purl.uniprot.org/uniprot/A0A6P3TDU0 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ASPN ^@ http://purl.uniprot.org/uniprot/A0A6P3E0K4|||http://purl.uniprot.org/uniprot/W5PEI2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||extracellular matrix http://togogenome.org/gene/9940:TEKT1 ^@ http://purl.uniprot.org/uniprot/W5NQ25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9940:ANGEL2 ^@ http://purl.uniprot.org/uniprot/A0A835ZXX2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MFNG ^@ http://purl.uniprot.org/uniprot/W5QD64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9940:ATP1B4 ^@ http://purl.uniprot.org/uniprot/W5PU88 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9940:DPEP3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFZ1|||http://purl.uniprot.org/uniprot/W5NZA0 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SRP68 ^@ http://purl.uniprot.org/uniprot/W5PEH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP68 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9940:LIN54 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-54 family.|||Nucleus http://togogenome.org/gene/9940:LOC101123383 ^@ http://purl.uniprot.org/uniprot/W5PVU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:LOC101106395 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8Z9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane|||Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NFX1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5S0|||http://purl.uniprot.org/uniprot/W5PIB9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NFX1 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RAB18 ^@ http://purl.uniprot.org/uniprot/W5Q3W4 ^@ Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Lipid droplet http://togogenome.org/gene/9940:LOC101103279 ^@ http://purl.uniprot.org/uniprot/W5P743 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GLMP family.|||Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.|||Lysosome membrane|||Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization. http://togogenome.org/gene/9940:C1H1orf54 ^@ http://purl.uniprot.org/uniprot/A0A6P3TNG8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM202 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFI1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TTC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ED65 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NDUFA11 ^@ http://purl.uniprot.org/uniprot/A0A8N7XJ91 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA11 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DLGAP5 ^@ http://purl.uniprot.org/uniprot/W5QIW2 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9940:PSMD2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E826 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S2 family.|||Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UBR2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EPS0|||http://purl.uniprot.org/uniprot/W5P0B8 ^@ Caution|||Function|||Similarity ^@ Belongs to the UBR1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/9940:AGPAT3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YFK2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Endoplasmic reticulum membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ESF1 ^@ http://purl.uniprot.org/uniprot/W5PND6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF1 family.|||nucleolus http://togogenome.org/gene/9940:STOML1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBV8|||http://purl.uniprot.org/uniprot/W5P2G0 ^@ Caution|||Similarity ^@ Belongs to the band 7/mec-2 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GNAT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YSC3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:N4BP3 ^@ http://purl.uniprot.org/uniprot/W5P7Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the N4BP3 family.|||Cytoplasmic vesicle|||Vesicle|||axon|||dendrite http://togogenome.org/gene/9940:SGCE ^@ http://purl.uniprot.org/uniprot/W5NWH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan alpha/epsilon family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.|||Golgi apparatus|||cytoskeleton|||dendrite|||sarcolemma http://togogenome.org/gene/9940:MFSD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3T3L1|||http://purl.uniprot.org/uniprot/A0A6P7D7N4 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ELAC1 ^@ http://purl.uniprot.org/uniprot/A0A836CS97 ^@ Caution|||Subunit ^@ Homodimer.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GABRE ^@ http://purl.uniprot.org/uniprot/A0A6P3ESW2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC8A1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TAS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:PSAP ^@ http://purl.uniprot.org/uniprot/W5PAJ2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9940:LOC101102327 ^@ http://purl.uniprot.org/uniprot/A0A6P3YPW3|||http://purl.uniprot.org/uniprot/W5NSR8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATP7B ^@ http://purl.uniprot.org/uniprot/Q9XT50 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.|||Each HMA domain can bind a copper ion, they are tightly packed and closely interact with each other. Wild-type ATP7B can usually be loaded with an average 5.5 copper atoms per molecule (By similarity).|||Late endosome|||Monomer. Interacts with COMMD1/MURR1 (By similarity). Interacts with DCTN4, in a copper-dependent manner (By similarity). Interacts with ATOX1 (By similarity). Interacts (via C-terminus) with ZBTB16/PLZF (By similarity).|||The short isoform is expressed primarily in the liver with lower levels present in the intestine, hypothalamus and ovary. The long isoform is expressed in the liver.|||trans-Golgi network membrane http://togogenome.org/gene/9940:GJB2 ^@ http://purl.uniprot.org/uniprot/A0A836CYR6|||http://purl.uniprot.org/uniprot/P46691 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||A hemichannel or connexon is composed of a hexamer of connexins. A functional gap junction is formed by the apposition of two hemichannels (By similarity). Forms heteromeric channels with GJB4. Interacts with CNST (By similarity).|||Belongs to the connexin family.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||Structural component of gap junctions (By similarity). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (By similarity).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||gap junction http://togogenome.org/gene/9940:CYTH1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TIF4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PSMD5 ^@ http://purl.uniprot.org/uniprot/W5P6M2 ^@ Similarity ^@ Belongs to the proteasome subunit S5B/HSM3 family. http://togogenome.org/gene/9940:LOC101104931 ^@ http://purl.uniprot.org/uniprot/W5PBS3 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:SLC11A1 ^@ http://purl.uniprot.org/uniprot/P49280 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAMP family.|||Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes (By similarity).|||Membrane http://togogenome.org/gene/9940:PON2 ^@ http://purl.uniprot.org/uniprot/B2LSM4 ^@ Cofactor|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit. http://togogenome.org/gene/9940:CEP44 ^@ http://purl.uniprot.org/uniprot/W5Q157 ^@ Subcellular Location Annotation ^@ Midbody|||centriole|||spindle pole http://togogenome.org/gene/9940:MRPS21 ^@ http://purl.uniprot.org/uniprot/A0A6P3E725 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/9940:TAC1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted|||Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. http://togogenome.org/gene/9940:TMEM200A ^@ http://purl.uniprot.org/uniprot/A0A6P3E6T8|||http://purl.uniprot.org/uniprot/A0A6P3TJJ2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GBX2 ^@ http://purl.uniprot.org/uniprot/W5QCV0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:KRT23 ^@ http://purl.uniprot.org/uniprot/W5Q1S9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9940:RORA ^@ http://purl.uniprot.org/uniprot/A0A0F7YLU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9940:SNW1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFH2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNW family.|||Identified in the spliceosome C complex.|||Involved in pre-mRNA splicing.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101104501 ^@ http://purl.uniprot.org/uniprot/W5NXE5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9940:METTL16 ^@ http://purl.uniprot.org/uniprot/W5Q2Q4 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METTL16/RlmF family.|||RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. http://togogenome.org/gene/9940:PCYT1A ^@ http://purl.uniprot.org/uniprot/A0A6P3T5H2 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/9940:TMED10 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBE7|||http://purl.uniprot.org/uniprot/W5NUK4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:B4GALNT2 ^@ http://purl.uniprot.org/uniprot/M1LF60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family.|||Membrane http://togogenome.org/gene/9940:C1QTNF7 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE94 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MTR ^@ http://purl.uniprot.org/uniprot/W5P0S6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin-B12 dependent methionine synthase family.|||Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.|||Cytoplasm|||Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin. http://togogenome.org/gene/9940:DCTN2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7U9 ^@ Caution|||Function|||Similarity ^@ Belongs to the dynactin subunit 2 family.|||Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MDFI ^@ http://purl.uniprot.org/uniprot/A0A835ZYA6|||http://purl.uniprot.org/uniprot/W5NW48 ^@ Caution|||Similarity ^@ Belongs to the MDFI family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NAALADL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFI2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RTF2 ^@ http://purl.uniprot.org/uniprot/W5Q9W6 ^@ Similarity|||Subunit ^@ Belongs to the rtf2 family.|||Interacts with DDI2; probably also interacts with DDI1. http://togogenome.org/gene/9940:TLCD2 ^@ http://purl.uniprot.org/uniprot/W5PWN3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:TM4SF1 ^@ http://purl.uniprot.org/uniprot/W5P478 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9940:ST3GAL4 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQD0|||http://purl.uniprot.org/uniprot/A8E1W0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC17A1 ^@ http://purl.uniprot.org/uniprot/W5NWH9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:NIT2 ^@ http://purl.uniprot.org/uniprot/W5Q9C4 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/9940:GOT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EKR0|||http://purl.uniprot.org/uniprot/W5PS88 ^@ Caution|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HIBCH ^@ http://purl.uniprot.org/uniprot/A0A6P3E146|||http://purl.uniprot.org/uniprot/W5Q437 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.|||Mitochondrion|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NKAPL ^@ http://purl.uniprot.org/uniprot/W5PH23 ^@ Similarity ^@ Belongs to the NKAP family. http://togogenome.org/gene/9940:WDR19 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6U2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MDH2 ^@ http://purl.uniprot.org/uniprot/W5PW05 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/9940:RGS4 ^@ http://purl.uniprot.org/uniprot/D3U1F9 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. http://togogenome.org/gene/9940:EXOSC10 ^@ http://purl.uniprot.org/uniprot/A0A6P3EI24 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101119566 ^@ http://purl.uniprot.org/uniprot/W5NR87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:CAT ^@ http://purl.uniprot.org/uniprot/A0A6P3EKV9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the catalase family.|||Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.|||Peroxisome|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POFUT1 ^@ http://purl.uniprot.org/uniprot/W5NZC9 ^@ Similarity ^@ Belongs to the glycosyltransferase 65 family. http://togogenome.org/gene/9940:EHD4 ^@ http://purl.uniprot.org/uniprot/W5QGX7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9940:SLC4A1 ^@ http://purl.uniprot.org/uniprot/W5PD87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.|||Membrane http://togogenome.org/gene/9940:LATS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EG36 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CP ^@ http://purl.uniprot.org/uniprot/Q9XT27|||http://purl.uniprot.org/uniprot/W5P4S0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the multicopper oxidase family.|||Binds 6 Cu cations per monomer.|||Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane (By similarity).|||Expressed by the liver and secreted in plasma. Also expressed in the hypothalamus, spleen and uterus. No expression in the cortex, heart, intestine or kidney.|||Secreted http://togogenome.org/gene/9940:MRPS12 ^@ http://purl.uniprot.org/uniprot/A0A6P3ELE7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/9940:HSD17B2 ^@ http://purl.uniprot.org/uniprot/I1W6S6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9940:CCL21 ^@ http://purl.uniprot.org/uniprot/W5PH56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9940:LOC101115926 ^@ http://purl.uniprot.org/uniprot/K4P217|||http://purl.uniprot.org/uniprot/W5P1B4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9940:FABP6 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4Z9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATP11B ^@ http://purl.uniprot.org/uniprot/W5QHL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9940:S1PR1 ^@ http://purl.uniprot.org/uniprot/A0A836AFT5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EPHX1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YPB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9940:TSPAN14 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9940:PFKFB4 ^@ http://purl.uniprot.org/uniprot/W5Q914 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9940:LOC101104465 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFI4|||http://purl.uniprot.org/uniprot/W5P755 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SNUPN ^@ http://purl.uniprot.org/uniprot/A0A835ZQ30 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snurportin family.|||Cytoplasm|||Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TFPI ^@ http://purl.uniprot.org/uniprot/W5Q4W4 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9940:GMPR2 ^@ http://purl.uniprot.org/uniprot/A0A836A2R5 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DOLK ^@ http://purl.uniprot.org/uniprot/A0A6P3E2B5|||http://purl.uniprot.org/uniprot/W5QCP5 ^@ Caution|||Similarity ^@ Belongs to the polyprenol kinase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101110717 ^@ http://purl.uniprot.org/uniprot/A0A6P3YPJ2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCT8 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4Q7|||http://purl.uniprot.org/uniprot/W5PYM5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cilium basal body http://togogenome.org/gene/9940:TMCO2 ^@ http://purl.uniprot.org/uniprot/A0A6P3DY40 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC35A1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGX7|||http://purl.uniprot.org/uniprot/W5PU48 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MYBL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHF6 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ACVR1 ^@ http://purl.uniprot.org/uniprot/A0A6P7DPQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9940:ARL4A ^@ http://purl.uniprot.org/uniprot/A0A6P3TKW4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATIC ^@ http://purl.uniprot.org/uniprot/W5QDE5 ^@ Similarity ^@ Belongs to the PurH family. http://togogenome.org/gene/9940:YOD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8I1|||http://purl.uniprot.org/uniprot/W5PAI3 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Cytoplasm|||Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PAF1 ^@ http://purl.uniprot.org/uniprot/A0A836A227|||http://purl.uniprot.org/uniprot/W5P7T3 ^@ Caution|||Similarity ^@ Belongs to the PAF1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ID2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9N8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM9 ^@ http://purl.uniprot.org/uniprot/A0A6P3YLQ2 ^@ Caution|||Similarity ^@ Belongs to the TMEM9 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HMGCL ^@ http://purl.uniprot.org/uniprot/W5PAS5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HMG-CoA lyase family.|||Homodimer; disulfide-linked. Can also form homotetramers.|||Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. http://togogenome.org/gene/9940:AASDHPPT ^@ http://purl.uniprot.org/uniprot/A0A6P3YMS5|||http://purl.uniprot.org/uniprot/W5NX68 ^@ Caution|||Similarity ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DBNDD1 ^@ http://purl.uniprot.org/uniprot/A0A836A2Y6|||http://purl.uniprot.org/uniprot/W5Q0S5 ^@ Caution|||Similarity ^@ Belongs to the dysbindin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101106376 ^@ http://purl.uniprot.org/uniprot/A0A6P3YEW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVBP family.|||Secreted|||cytoskeleton http://togogenome.org/gene/9940:SNRNP40 ^@ http://purl.uniprot.org/uniprot/A0A6P3E242 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101118736 ^@ http://purl.uniprot.org/uniprot/A0A835ZMU2|||http://purl.uniprot.org/uniprot/W5Q7R3 ^@ Caution|||Subcellular Location Annotation ^@ Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HES5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8R6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TLR10 ^@ http://purl.uniprot.org/uniprot/B5DC95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9940:DHX15 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDW7|||http://purl.uniprot.org/uniprot/W5P7B4 ^@ Caution|||Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDC42 ^@ http://purl.uniprot.org/uniprot/M4WED3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Membrane|||Midbody|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.|||centrosome http://togogenome.org/gene/9940:TOMM70 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZJ3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IL1RN ^@ http://purl.uniprot.org/uniprot/M4WHI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.|||Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9940:SNRPB ^@ http://purl.uniprot.org/uniprot/A0A6P3YL13|||http://purl.uniprot.org/uniprot/W5P9V9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP SmB/SmN family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NDRG3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBX6|||http://purl.uniprot.org/uniprot/A0A6P3TMS0 ^@ Caution|||Similarity ^@ Belongs to the NDRG family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EPB41L5 ^@ http://purl.uniprot.org/uniprot/W5PTM7 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||Membrane|||Photoreceptor inner segment|||Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. http://togogenome.org/gene/9940:LOC101117706 ^@ http://purl.uniprot.org/uniprot/A0A6P3TBY5|||http://purl.uniprot.org/uniprot/W5PXU4 ^@ Caution|||Similarity ^@ Belongs to the G-protein coupled receptor 1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NSFL1C ^@ http://purl.uniprot.org/uniprot/A0A6P3EBT8|||http://purl.uniprot.org/uniprot/W5QB13 ^@ Caution|||Subcellular Location Annotation|||Subunit ^@ Golgi stack|||Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NDUFA1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FRJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9940:CXCL9 ^@ http://purl.uniprot.org/uniprot/A0A836A218|||http://purl.uniprot.org/uniprot/W5Q4X6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MCP1 ^@ http://purl.uniprot.org/uniprot/P80931 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the peptidase S1 family. Granzyme subfamily.|||Cytoplasmic granule|||Has a chymotrypsin-like and trypsin-like activity.|||Mucosal mast cells.|||Secreted http://togogenome.org/gene/9940:CEL ^@ http://purl.uniprot.org/uniprot/W5P5Z7 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/9940:NTF3 ^@ http://purl.uniprot.org/uniprot/W5PGZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted|||Seems to promote the survival of visceral and proprioceptive sensory neurons. http://togogenome.org/gene/9940:AARS1 ^@ http://purl.uniprot.org/uniprot/W5P5H4 ^@ Cofactor|||Domain|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||ISGylated.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/9940:CRH ^@ http://purl.uniprot.org/uniprot/W5Q7H6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/9940:LPAR4 ^@ http://purl.uniprot.org/uniprot/A0A6P3ES60|||http://purl.uniprot.org/uniprot/W5P7T0 ^@ Caution|||Similarity ^@ Belongs to the G-protein coupled receptor 1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101121414 ^@ http://purl.uniprot.org/uniprot/W5QBI2 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9940:PMAIP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDZ4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC37A4 ^@ http://purl.uniprot.org/uniprot/A0A836CVW7|||http://purl.uniprot.org/uniprot/W5PS34|||http://purl.uniprot.org/uniprot/W5PS35 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRELID1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECS1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IL11RA ^@ http://purl.uniprot.org/uniprot/A0A6P3E7W3|||http://purl.uniprot.org/uniprot/A0A6P3TBS7 ^@ Caution|||Similarity ^@ Belongs to the type I cytokine receptor family. Type 3 subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101108747 ^@ http://purl.uniprot.org/uniprot/A0A6P3TGP4 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAHD2A ^@ http://purl.uniprot.org/uniprot/A0A836A9M9 ^@ Caution|||Similarity ^@ Belongs to the FAH family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ITGAM ^@ http://purl.uniprot.org/uniprot/A2TJJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9940:LOC101111060 ^@ http://purl.uniprot.org/uniprot/W5QE95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the argonaute family.|||P-body http://togogenome.org/gene/9940:TMEM107 ^@ http://purl.uniprot.org/uniprot/A0A6P3ED64 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RBM27 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE89 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SMIM14 ^@ http://purl.uniprot.org/uniprot/A0A6P3EF19 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NCBP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E154|||http://purl.uniprot.org/uniprot/W5PNL4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NCBP1 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NDUFS3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EKX5 ^@ Caution|||Similarity ^@ Belongs to the complex I 30 kDa subunit family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ALCAM ^@ http://purl.uniprot.org/uniprot/W5QBM4 ^@ Subcellular Location Annotation ^@ Cell membrane|||axon|||dendrite http://togogenome.org/gene/9940:SLC35B4 ^@ http://purl.uniprot.org/uniprot/A0A836A5H4|||http://purl.uniprot.org/uniprot/W5PB80 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PSMA1 ^@ http://purl.uniprot.org/uniprot/W5P9U4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9940:LOC101103726 ^@ http://purl.uniprot.org/uniprot/W5NR12 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9940:LOC101106925 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB73|||http://purl.uniprot.org/uniprot/W5QHS2 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.|||Belongs to the osteocalcin/matrix Gla protein family.|||Requires vitamin K-dependent gamma-carboxylation for its function.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:WDR59 ^@ http://purl.uniprot.org/uniprot/A0A6P3EKV7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:B4GALT6 ^@ http://purl.uniprot.org/uniprot/A0A6P3EL23|||http://purl.uniprot.org/uniprot/W5P8J6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101103029 ^@ http://purl.uniprot.org/uniprot/W5PZQ4 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. http://togogenome.org/gene/9940:EIF4ENIF1 ^@ http://purl.uniprot.org/uniprot/W5PLR2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9940:FAM76B ^@ http://purl.uniprot.org/uniprot/A0A6P3ECQ0 ^@ Caution|||Similarity ^@ Belongs to the FAM76 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101110467 ^@ http://purl.uniprot.org/uniprot/A0A6P3TTC7|||http://purl.uniprot.org/uniprot/W5Q9H6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9940:DCTN3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5R0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CRYGS ^@ http://purl.uniprot.org/uniprot/W5QH67 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9940:MRPL24 ^@ http://purl.uniprot.org/uniprot/A0A6P3TVI1 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL24 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STMN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E1Y4 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9940:ADGRG6 ^@ http://purl.uniprot.org/uniprot/W5NTH3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9940:CRISP2 ^@ http://purl.uniprot.org/uniprot/D6PX63 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:PTGS1 ^@ http://purl.uniprot.org/uniprot/P05979 ^@ Activity Regulation|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prostaglandin G/H synthase family.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|||Conversion of arachidonate to prostaglandin H2 is mediated by 2 different isozymes: the constitutive PTGS1 and the inducible PTGS2. PTGS1 is expressed constitutively and generally produces prostanoids acutely in response to hormonal stimuli to fine-tune physiological processes requiring instantaneous, continuous regulation (e.g. hemostasis). PTGS2 is inducible and typically produces prostanoids that mediate responses to physiological stresses such as infection and inflammation.|||Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons (PubMed:7947975). Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (PubMed:10438452).|||Endoplasmic reticulum membrane|||Homodimer.|||Microsome membrane|||PTGS1 and PTGS2 are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin and ibuprofen. Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation. Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic events, as well as the development of colon cancer and Alzheimer's disease. PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration.|||The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. The peroxidase reaction occurs at a heme-containing active site located near the protein surface. The nonsteroidal anti-inflammatory drugs (NSAIDs) binding site corresponds to the cyclooxygenase active site.|||The cyclooxygenase activity is inhibited by nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen, flurbiprofen, ketoprofen, naproxen, flurbiprofen, anirolac, fenclofenac and diclofenac. http://togogenome.org/gene/9940:FOXO3 ^@ http://purl.uniprot.org/uniprot/A0A6P3CXG2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:LSM14A ^@ http://purl.uniprot.org/uniprot/A0A6P3EFJ6|||http://purl.uniprot.org/uniprot/W5P2Y8 ^@ Caution|||Similarity ^@ Belongs to the LSM14 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CHRNA1 ^@ http://purl.uniprot.org/uniprot/W5NQ02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9940:TMEM89 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEM9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATP1B3 ^@ http://purl.uniprot.org/uniprot/A0A6P7EUT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9940:PTTG1 ^@ http://purl.uniprot.org/uniprot/A0A836ADD8|||http://purl.uniprot.org/uniprot/W5PVM2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the securin family.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ERGIC3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBW9|||http://purl.uniprot.org/uniprot/W5PVC8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NLRP1 ^@ http://purl.uniprot.org/uniprot/W5NXB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NLRP family.|||Inflammasome|||cytosol http://togogenome.org/gene/9940:LOC101104151 ^@ http://purl.uniprot.org/uniprot/W5PZ55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9940:WDR55 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4T7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR55 family.|||Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:MRPL1 ^@ http://purl.uniprot.org/uniprot/W5Q8S0 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9940:ALDH1A2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E685|||http://purl.uniprot.org/uniprot/W5QI69 ^@ Caution|||Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IZUMO1 ^@ http://purl.uniprot.org/uniprot/C6ZEB0 ^@ Similarity ^@ Belongs to the Izumo family. http://togogenome.org/gene/9940:HOMER1 ^@ http://purl.uniprot.org/uniprot/W5Q772 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/9940:NMUR2 ^@ http://purl.uniprot.org/uniprot/W5PHQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/9940:LOC101103182 ^@ http://purl.uniprot.org/uniprot/W5P456 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9940:IL21 ^@ http://purl.uniprot.org/uniprot/H6SGV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/9940:CLDN6 ^@ http://purl.uniprot.org/uniprot/W5PLQ0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9940:MGA ^@ http://purl.uniprot.org/uniprot/W5QGR9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9940:ALX1 ^@ http://purl.uniprot.org/uniprot/W5Q1B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9940:MTNR1A ^@ http://purl.uniprot.org/uniprot/P48040 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. http://togogenome.org/gene/9940:PRPF18 ^@ http://purl.uniprot.org/uniprot/A0A6P3TJ94|||http://purl.uniprot.org/uniprot/W5P8D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/9940:BCAT1 ^@ http://purl.uniprot.org/uniprot/Q9GKM4|||http://purl.uniprot.org/uniprot/W5QFT5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.|||Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.|||Cytoplasm|||Expressed in muscles.|||Homodimer. http://togogenome.org/gene/9940:TNFSF10 ^@ http://purl.uniprot.org/uniprot/W5QHU1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Homotrimer.|||Membrane|||Secreted http://togogenome.org/gene/9940:SLC25A4 ^@ http://purl.uniprot.org/uniprot/B2MVW8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9940:EEF2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TM14 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. http://togogenome.org/gene/9940:LOC105612015 ^@ http://purl.uniprot.org/uniprot/A0A6P3TIB2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HSD17B12 ^@ http://purl.uniprot.org/uniprot/A0A6P3ED76|||http://purl.uniprot.org/uniprot/A0A6P7D784 ^@ Caution|||Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLAC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3T7J3|||http://purl.uniprot.org/uniprot/W5PIH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PLAC1 family.|||Secreted http://togogenome.org/gene/9940:SLC35G2 ^@ http://purl.uniprot.org/uniprot/A0A836AQN8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NUDT9 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQS2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC105612194 ^@ http://purl.uniprot.org/uniprot/W5PHD9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:VSIR ^@ http://purl.uniprot.org/uniprot/A0A6P3EGQ7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DAG1 ^@ http://purl.uniprot.org/uniprot/W5PVZ9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.|||Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.|||cytoskeleton|||extracellular space|||nucleoplasm|||sarcolemma http://togogenome.org/gene/9940:ADGRF1 ^@ http://purl.uniprot.org/uniprot/W5PPK1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:SAP130 ^@ http://purl.uniprot.org/uniprot/W5Q362 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAP130 family.|||Nucleus http://togogenome.org/gene/9940:FCGRT ^@ http://purl.uniprot.org/uniprot/A0A6P7EP66 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EPGN ^@ http://purl.uniprot.org/uniprot/W5PZZ5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:SLITRK3 ^@ http://purl.uniprot.org/uniprot/W5PZM0 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9940:LOC101109827 ^@ http://purl.uniprot.org/uniprot/A0A6P3TBU9|||http://purl.uniprot.org/uniprot/A0A6P7EVV9 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZC3H15 ^@ http://purl.uniprot.org/uniprot/A0A6P3E660|||http://purl.uniprot.org/uniprot/W5Q562 ^@ Caution|||Similarity ^@ Belongs to the ZC3H15/TMA46 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101105044 ^@ http://purl.uniprot.org/uniprot/W5PAC2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9940:DDX41 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDW3|||http://purl.uniprot.org/uniprot/W5P6C3 ^@ Caution|||Similarity ^@ Belongs to the DEAD box helicase family. DDX41 subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KATNA1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8T1 ^@ Activity Regulation|||Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Midbody|||Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.|||The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.|||centrosome|||spindle|||spindle pole http://togogenome.org/gene/9940:HOXB13 ^@ http://purl.uniprot.org/uniprot/W5PA69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9940:SFTA2 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECT0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SMPX ^@ http://purl.uniprot.org/uniprot/A0A6P3EMQ3 ^@ Function|||Similarity ^@ Belongs to the SMPX family.|||Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. http://togogenome.org/gene/9940:CCNE1 ^@ http://purl.uniprot.org/uniprot/W5P1P9 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin E subfamily. http://togogenome.org/gene/9940:TMEM252 ^@ http://purl.uniprot.org/uniprot/A0A6P3E0W5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ALOX12B ^@ http://purl.uniprot.org/uniprot/W5QBJ9 ^@ Caution|||Similarity ^@ Belongs to the lipoxygenase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:CACNG6 ^@ http://purl.uniprot.org/uniprot/W5NS49 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. http://togogenome.org/gene/9940:LOC101112287 ^@ http://purl.uniprot.org/uniprot/W5PGR4 ^@ Similarity ^@ Belongs to the spermidine/spermine synthase family. http://togogenome.org/gene/9940:SAYSD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EER9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ABCG2 ^@ http://purl.uniprot.org/uniprot/Q009B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Cell membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9940:CLUAP1 ^@ http://purl.uniprot.org/uniprot/W5NUY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLUAP1 family.|||cilium http://togogenome.org/gene/9940:ACOT8 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC02|||http://purl.uniprot.org/uniprot/W5PA22 ^@ Caution|||Similarity ^@ Belongs to the C/M/P thioester hydrolase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TAP2 ^@ http://purl.uniprot.org/uniprot/A0A6P7D6F7 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. http://togogenome.org/gene/9940:ANGPTL3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E416 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LRRN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EPC8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RHAG ^@ http://purl.uniprot.org/uniprot/W5PRU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9940:TCEAL8 ^@ http://purl.uniprot.org/uniprot/A0A835ZPS0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TXNL4A ^@ http://purl.uniprot.org/uniprot/A0A6P3EFY3|||http://purl.uniprot.org/uniprot/W5P1U0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ST3GAL6 ^@ http://purl.uniprot.org/uniprot/A0A6P3TUJ5|||http://purl.uniprot.org/uniprot/W5Q8L9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DNAI2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TLF9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZMYND10 ^@ http://purl.uniprot.org/uniprot/W5PIJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the ZMYND10 family.|||Dynein axonemal particle|||Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.|||centriolar satellite http://togogenome.org/gene/9940:TYR ^@ http://purl.uniprot.org/uniprot/A7LK11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/9940:MTF1 ^@ http://purl.uniprot.org/uniprot/A0A836D6P9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C5H5orf24 ^@ http://purl.uniprot.org/uniprot/W5PUW6 ^@ Similarity ^@ Belongs to the UPF0461 family. http://togogenome.org/gene/9940:BBS5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8L7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BBS5 family.|||Membrane|||Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||centriolar satellite|||cilium membrane http://togogenome.org/gene/9940:CXCL16 ^@ http://purl.uniprot.org/uniprot/A0A6P7EKD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Membrane http://togogenome.org/gene/9940:USP39 ^@ http://purl.uniprot.org/uniprot/A0A6P3YID2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:OTX2 ^@ http://purl.uniprot.org/uniprot/A0A6P7EXI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9940:ECE1 ^@ http://purl.uniprot.org/uniprot/W5PFK6 ^@ Function ^@ Converts big endothelin-1 to endothelin-1. http://togogenome.org/gene/9940:NUDT18 ^@ http://purl.uniprot.org/uniprot/A0A6P3E0Q9 ^@ Caution|||Similarity ^@ Belongs to the Nudix hydrolase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PIGK ^@ http://purl.uniprot.org/uniprot/W5PTI2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C13 family.|||Endoplasmic reticulum membrane|||Forms a complex with PIGT, PIGS, PIGU and GAA1.|||Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. http://togogenome.org/gene/9940:CNOT2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TLJ2|||http://purl.uniprot.org/uniprot/W5QG54 ^@ Caution|||Similarity ^@ Belongs to the CNOT2/3/5 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NDUFAF1 ^@ http://purl.uniprot.org/uniprot/W5QGK9 ^@ Function|||Similarity ^@ As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the CIA30 family. http://togogenome.org/gene/9940:B3GNT2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E762|||http://purl.uniprot.org/uniprot/W5QE49 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZNF655 ^@ http://purl.uniprot.org/uniprot/A0A6P3ERT2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CFAP298 ^@ http://purl.uniprot.org/uniprot/W5PVP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP298 family.|||cilium basal body http://togogenome.org/gene/9940:SCGB1C1 ^@ http://purl.uniprot.org/uniprot/W5PHG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the secretoglobin family.|||Secreted http://togogenome.org/gene/9940:SIX1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FRF6|||http://purl.uniprot.org/uniprot/D3U1G0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SIX/Sine oculis homeobox family.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CRYBB2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YR18|||http://purl.uniprot.org/uniprot/W5QCG5 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GCSAM ^@ http://purl.uniprot.org/uniprot/A0A6P3E7U2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HAUS1 ^@ http://purl.uniprot.org/uniprot/W5NYC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS1 family.|||spindle http://togogenome.org/gene/9940:TAS2R1 ^@ http://purl.uniprot.org/uniprot/A0A835ZRP1|||http://purl.uniprot.org/uniprot/W5P6X6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RNF13 ^@ http://purl.uniprot.org/uniprot/A0A6P3E0F8|||http://purl.uniprot.org/uniprot/A0A6P3TEX6 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101119832 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGX0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TAF12 ^@ http://purl.uniprot.org/uniprot/A0A6P3T9R0|||http://purl.uniprot.org/uniprot/A0A6P3TI94 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF12 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATP5MC1 ^@ http://purl.uniprot.org/uniprot/A0A836A709|||http://purl.uniprot.org/uniprot/P17605 ^@ Caution|||Disease Annotation|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase C chain family.|||Homooligomer (By similarity). F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with TMEM70 (homooligomer form); this interaction facilitates the oligomer formation of subunit c/ATP5MC1 (c-ring) and the c-ring membrane insertion and also protects ATP5MC1 against intramitochondrial proteolysis (By similarity).|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||There are three genes which encode the ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins.|||This protein is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).|||Trimethylated by ATPSCKMT at Lys-104. Methylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration. http://togogenome.org/gene/9940:CD81 ^@ http://purl.uniprot.org/uniprot/B2MVW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9940:UMPS ^@ http://purl.uniprot.org/uniprot/A0A836D7G9 ^@ Caution|||Similarity ^@ In the C-terminal section; belongs to the OMP decarboxylase family.|||In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101105010 ^@ http://purl.uniprot.org/uniprot/A0A6P3EA30 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RHBDD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EA60|||http://purl.uniprot.org/uniprot/A0A6P3TI30 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HHIPL2 ^@ http://purl.uniprot.org/uniprot/W5PV41 ^@ Similarity ^@ Belongs to the HHIP family. http://togogenome.org/gene/9940:PROM2 ^@ http://purl.uniprot.org/uniprot/W5PXF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/9940:LOC101118606 ^@ http://purl.uniprot.org/uniprot/A0A6P3TD01 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMLHE ^@ http://purl.uniprot.org/uniprot/W5P0Q7 ^@ Similarity ^@ Belongs to the gamma-BBH/TMLD family. http://togogenome.org/gene/9940:PITX3 ^@ http://purl.uniprot.org/uniprot/D3GN34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9940:HPSE ^@ http://purl.uniprot.org/uniprot/W5NWF9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/9940:SLC30A7 ^@ http://purl.uniprot.org/uniprot/C7BDW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Functions as a zinc transporter.|||Homooligomer.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9940:UBTD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YNU7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101118053 ^@ http://purl.uniprot.org/uniprot/W5P441 ^@ Function|||Subcellular Location Annotation ^@ May function as a transcription factor.|||Nucleus http://togogenome.org/gene/9940:LOC443348 ^@ http://purl.uniprot.org/uniprot/Q28546 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9940:LOC101119721 ^@ http://purl.uniprot.org/uniprot/A0A8N7XJB5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TSG101 ^@ http://purl.uniprot.org/uniprot/A0A6P3ED58|||http://purl.uniprot.org/uniprot/W5PID5 ^@ Caution|||Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ITGA2B ^@ http://purl.uniprot.org/uniprot/W5PEX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9940:EIF2S1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6D2|||http://purl.uniprot.org/uniprot/A0A6P3EBC0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Stress granule|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLK4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDW9|||http://purl.uniprot.org/uniprot/W5P9Q7 ^@ Caution|||Similarity ^@ Belongs to the protein kinase superfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IL1A ^@ http://purl.uniprot.org/uniprot/Q28579|||http://purl.uniprot.org/uniprot/W5QI89 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated within its nuclear localization sequence, which impacts subcellular localization.|||Belongs to the IL-1 family.|||Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.|||Cytoplasm|||Monomer. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Interacts with IL1R1. Interacts with S100A13; this interaction is the first step in the export of IL1A, followed by direct translocation of this complex across the plasma membrane.|||Nucleus|||Phosphorylated. Phosphorylation greatly enhances susceptibility to digestion and promotes the conversion of pre-IL1A alpha to the biologically active IL1A.|||Proteolytic processed by CAPN1 in a calcium-dependent manner. Cleavage from 31 kDa precursor to 18 kDa biologically active molecules.|||Secreted|||The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function. http://togogenome.org/gene/9940:METTL13 ^@ http://purl.uniprot.org/uniprot/A0A836A6W2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MESD ^@ http://purl.uniprot.org/uniprot/W5Q230 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MESD family.|||Endoplasmic reticulum http://togogenome.org/gene/9940:LOC101108279 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7L9|||http://purl.uniprot.org/uniprot/W5NTY7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POP4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJK9|||http://purl.uniprot.org/uniprot/W5P1L8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Component of nuclear RNase P and RNase MRP.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:ATP2B1 ^@ http://purl.uniprot.org/uniprot/W5Q289 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||Membrane|||Presynaptic cell membrane|||Synaptic cell membrane|||synaptic vesicle membrane http://togogenome.org/gene/9940:ECHDC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TPR1 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9940:LOC780442 ^@ http://purl.uniprot.org/uniprot/Q5G2C6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CybS family.|||Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/9940:SLC12A1 ^@ http://purl.uniprot.org/uniprot/W5QIP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:RPL7 ^@ http://purl.uniprot.org/uniprot/A0A6P7DK24|||http://purl.uniprot.org/uniprot/A0A836A4W4 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL30 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CUTC ^@ http://purl.uniprot.org/uniprot/A0A6P3EQ10|||http://purl.uniprot.org/uniprot/W5PTA5 ^@ Caution|||Similarity ^@ Belongs to the CutC family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PTCRA ^@ http://purl.uniprot.org/uniprot/A0A6P3EJ44 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101119648 ^@ http://purl.uniprot.org/uniprot/W5Q6C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9940:LPIN2 ^@ http://purl.uniprot.org/uniprot/A0A835ZR38|||http://purl.uniprot.org/uniprot/W5PK41 ^@ Caution|||Similarity ^@ Belongs to the lipin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101110189 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJW9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101105400 ^@ http://purl.uniprot.org/uniprot/A0A836ADA3 ^@ Caution|||Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LGALS3 ^@ http://purl.uniprot.org/uniprot/W5QIW1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9940:P2RY13 ^@ http://purl.uniprot.org/uniprot/A0A6P3TCK8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPP21 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJF2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CREM ^@ http://purl.uniprot.org/uniprot/A7KP99 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:LOC101109479 ^@ http://purl.uniprot.org/uniprot/W5Q6S4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:TIMM21 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDT2|||http://purl.uniprot.org/uniprot/W5P3Q1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM21 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane|||Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TCHHL1 ^@ http://purl.uniprot.org/uniprot/A0A836AP85 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:USP9X ^@ http://purl.uniprot.org/uniprot/A0A6P3TFG6|||http://purl.uniprot.org/uniprot/W5NVJ3 ^@ Caution|||Similarity ^@ Belongs to the peptidase C19 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDC123 ^@ http://purl.uniprot.org/uniprot/W5Q111 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC123 family.|||Cytoplasm|||Required for S phase entry of the cell cycle. http://togogenome.org/gene/9940:C12H1orf115 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHX4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARF6 ^@ http://purl.uniprot.org/uniprot/C5IWU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Cell membrane|||Cleavage furrow|||Endosome membrane|||Midbody ring|||Recycling endosome membrane|||filopodium membrane|||ruffle http://togogenome.org/gene/9940:SLC39A1 ^@ http://purl.uniprot.org/uniprot/C7BDW2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:FGD4 ^@ http://purl.uniprot.org/uniprot/W5QDJ8 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9940:XPNPEP2 ^@ http://purl.uniprot.org/uniprot/W5Q009 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/9940:RPS18 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENG9 ^@ Caution|||Function|||Similarity ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PKN2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TFC1|||http://purl.uniprot.org/uniprot/W5Q018 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cleavage furrow|||Cytoplasm|||Midbody|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EMC7 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAW9|||http://purl.uniprot.org/uniprot/W5QF74 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the EMC7 family.|||Component of the ER membrane protein complex (EMC).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:S100A4 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZN7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Nucleus|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC35F1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6K9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:REM1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TSZ3 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9940:ABITRAM ^@ http://purl.uniprot.org/uniprot/A0A6P3E0W8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABITRAM family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||growth cone|||lamellipodium http://togogenome.org/gene/9940:MSH3 ^@ http://purl.uniprot.org/uniprot/W5PZR8 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR). http://togogenome.org/gene/9940:SGK2 ^@ http://purl.uniprot.org/uniprot/A0A6P7ENR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily.|||Cytoplasm http://togogenome.org/gene/9940:EPG5 ^@ http://purl.uniprot.org/uniprot/W5NX74 ^@ Similarity ^@ Belongs to the EPG5 family. http://togogenome.org/gene/9940:SUCLG2 ^@ http://purl.uniprot.org/uniprot/W5PL67 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.|||Binds 1 Mg(2+) ion per subunit.|||GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.|||Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.|||Mitochondrion http://togogenome.org/gene/9940:PTGFR ^@ http://purl.uniprot.org/uniprot/A0A836AP34|||http://purl.uniprot.org/uniprot/Q28905 ^@ Caution|||Developmental Stage|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Expression is high in the midluteal phase corpus luteum and decreases during luteolysis.|||Membrane|||Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum.|||Shows agonist-independent constitutive activity, but is still responsive to agonist.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101112590 ^@ http://purl.uniprot.org/uniprot/A0A088Q711 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9940:CYRIA ^@ http://purl.uniprot.org/uniprot/A0A6P3TKH9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CYRI family.|||Interacts with RAC1 (GTP-bound form preferentially).|||Membrane http://togogenome.org/gene/9940:ALDH7A1 ^@ http://purl.uniprot.org/uniprot/W5QAE8 ^@ Similarity|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/9940:DCT ^@ http://purl.uniprot.org/uniprot/B3VKX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/9940:SPR ^@ http://purl.uniprot.org/uniprot/A0A836A7E0|||http://purl.uniprot.org/uniprot/W5PPU0 ^@ Caution|||Similarity ^@ Belongs to the sepiapterin reductase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101108705 ^@ http://purl.uniprot.org/uniprot/A0A836APA1 ^@ Caution|||Similarity ^@ Belongs to the GST superfamily. Mu family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TIGD4 ^@ http://purl.uniprot.org/uniprot/W5Q0B7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:FBXL21P ^@ http://purl.uniprot.org/uniprot/B3FL73 ^@ Function|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Expressed in the adenohypophysis, hypothalamus (especially in the suprachiasmatic nucleus or nuclei, SCN) and pineal, all neuroendocrine structures associated with timing and homeostasis.|||Nucleus|||Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL21) composed of CUL1, SKP1, RBX1 and FBXL21. Interacts with CRY2 (By similarity). Interacts with CRY1.|||Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities.|||cytosol http://togogenome.org/gene/9940:PIAS2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YTC9 ^@ Caution|||Similarity ^@ Belongs to the PIAS family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLAAT3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDB4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ADGRD1 ^@ http://purl.uniprot.org/uniprot/W5PZY4|||http://purl.uniprot.org/uniprot/W5PZY6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9940:CCDC107 ^@ http://purl.uniprot.org/uniprot/A0A6P3E0T9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAM124B ^@ http://purl.uniprot.org/uniprot/W5QGS7 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/9940:HERPUD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJF3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NSL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJX7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RGN ^@ http://purl.uniprot.org/uniprot/B3VSC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm http://togogenome.org/gene/9940:NELFCD ^@ http://purl.uniprot.org/uniprot/A0A6P3YM18 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NELF-D family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CRIPT ^@ http://purl.uniprot.org/uniprot/A0A6P3EB18 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRIPT family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AMPD3 ^@ http://purl.uniprot.org/uniprot/W5PNN0 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/9940:LOC101103602 ^@ http://purl.uniprot.org/uniprot/W5NWU7 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/9940:SLC45A2 ^@ http://purl.uniprot.org/uniprot/W5PQN6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:GSS ^@ http://purl.uniprot.org/uniprot/W5PMH1 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic GSH synthase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/9940:ZMAT3 ^@ http://purl.uniprot.org/uniprot/A0A6P3T2I1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CRY1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TA66|||http://purl.uniprot.org/uniprot/A0A836D841|||http://purl.uniprot.org/uniprot/W5Q8S7 ^@ Caution|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:VAMP7 ^@ http://purl.uniprot.org/uniprot/A0A6P9FRF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9940:ODF3L1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE92 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CASP9 ^@ http://purl.uniprot.org/uniprot/A0A836CYM2|||http://purl.uniprot.org/uniprot/W5PIY5 ^@ Caution|||Similarity ^@ Belongs to the peptidase C14A family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TBC1D23 ^@ http://purl.uniprot.org/uniprot/W5Q9B7|||http://purl.uniprot.org/uniprot/W5Q9B8 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/9940:PEX3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBZ6 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with PEX19.|||Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.|||Peroxisome membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC114108702 ^@ http://purl.uniprot.org/uniprot/A0A6P7DS10 ^@ Similarity ^@ Belongs to the cornifin (SPRR) family. http://togogenome.org/gene/9940:TAF5 ^@ http://purl.uniprot.org/uniprot/W5NZT1 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/9940:ANKRD13A ^@ http://purl.uniprot.org/uniprot/A0A6P3EBK7 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/9940:ZACN ^@ http://purl.uniprot.org/uniprot/W5PE38 ^@ Subcellular Location Annotation ^@ Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9940:GLRA3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9G5|||http://purl.uniprot.org/uniprot/W5Q126 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MIEN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHE8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC25A15 ^@ http://purl.uniprot.org/uniprot/A0A6P3YJJ7|||http://purl.uniprot.org/uniprot/B2MVX3|||http://purl.uniprot.org/uniprot/W5PIF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9940:WSCD2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EMF5|||http://purl.uniprot.org/uniprot/A0A6P3T237 ^@ Caution|||Similarity ^@ Belongs to the WSCD family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC443322 ^@ http://purl.uniprot.org/uniprot/R9QYM6 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 22 family.|||Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. http://togogenome.org/gene/9940:DRD2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EG64 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Golgi apparatus membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PSMD13 ^@ http://purl.uniprot.org/uniprot/A0A6P3EKA2|||http://purl.uniprot.org/uniprot/W5PFU1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S11 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EDNRB ^@ http://purl.uniprot.org/uniprot/A0A1X9T5Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:TMIE ^@ http://purl.uniprot.org/uniprot/A0A836A034 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PHF5A ^@ http://purl.uniprot.org/uniprot/A0A6P3E3L9 ^@ Caution|||Similarity ^@ Belongs to the PHF5 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BORCS5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3F1|||http://purl.uniprot.org/uniprot/W5QI72 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS5 family.|||Lysosome membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PKP4 ^@ http://purl.uniprot.org/uniprot/W5PCM5 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9940:PDCD4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EKV3 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/9940:LOC101121054 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6X7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101101979 ^@ http://purl.uniprot.org/uniprot/A0A6P3TDD8 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9940:ATP6V1A ^@ http://purl.uniprot.org/uniprot/A0A6P3DZL2|||http://purl.uniprot.org/uniprot/A0A6P7EWC9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||clathrin-coated vesicle membrane|||secretory vesicle http://togogenome.org/gene/9940:FGF11 ^@ http://purl.uniprot.org/uniprot/A0A6P3ED48|||http://purl.uniprot.org/uniprot/W5PV88 ^@ Caution|||Similarity ^@ Belongs to the heparin-binding growth factors family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TASOR2 ^@ http://purl.uniprot.org/uniprot/W5PEW1 ^@ Similarity ^@ Belongs to the TASOR family. http://togogenome.org/gene/9940:PDXK ^@ http://purl.uniprot.org/uniprot/P82197 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Activated by K(+) (Probable). Activity is increased in the presence of Na(+) (By similarity).|||Belongs to the pyridoxine kinase family.|||Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (PubMed:14722069) (By similarity). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions (By similarity).|||Homodimer.|||Ubiquitous.|||cytosol http://togogenome.org/gene/9940:CHRNB3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TKF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9940:MNS1 ^@ http://purl.uniprot.org/uniprot/A0A836AC46 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MNS1 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cilium axoneme|||flagellum axoneme http://togogenome.org/gene/9940:ZER1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YKE1 ^@ Caution|||Similarity ^@ Belongs to the zyg-11 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ERGIC2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC65|||http://purl.uniprot.org/uniprot/A0A6P3TQH6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCAR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YT98 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TAF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TFS8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF1 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101103853 ^@ http://purl.uniprot.org/uniprot/W5Q1C0 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:KAT7 ^@ http://purl.uniprot.org/uniprot/W5P6L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9940:TRMT6 ^@ http://purl.uniprot.org/uniprot/A0A6P3EIQ4|||http://purl.uniprot.org/uniprot/W5Q9C2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM6/GCD10 family.|||Heterotetramer.|||Nucleus|||Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCHCR1 ^@ http://purl.uniprot.org/uniprot/W5PKV4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be a regulator of keratinocyte proliferation or differentiation.|||Nucleus http://togogenome.org/gene/9940:ABCG4 ^@ http://purl.uniprot.org/uniprot/A0A835ZZ28|||http://purl.uniprot.org/uniprot/W5PWX0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TPT1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQR6 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/9940:PREB ^@ http://purl.uniprot.org/uniprot/A0A6P3E726|||http://purl.uniprot.org/uniprot/W5QCW4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat SEC12 family.|||Endoplasmic reticulum membrane|||Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.|||Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. http://togogenome.org/gene/9940:RUVBL2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJV9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HSPA1A ^@ http://purl.uniprot.org/uniprot/H2DGR2 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9940:AVPR1A ^@ http://purl.uniprot.org/uniprot/E3V2E4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. http://togogenome.org/gene/9940:LOC101115423 ^@ http://purl.uniprot.org/uniprot/W5PAF1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:PEX14 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8P8|||http://purl.uniprot.org/uniprot/W5P4D3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-14 family.|||Component of the peroxisomal translocation machinery.|||Peroxisome membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SPP2 ^@ http://purl.uniprot.org/uniprot/A0A836APB1|||http://purl.uniprot.org/uniprot/Q70TH4|||http://purl.uniprot.org/uniprot/W5QCY7 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPP2 family.|||Could coordinate an aspect of bone turnover.|||Multiply phosphorylated at serine residues.|||Phosphorylation sites are present in the extracellular medium.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SORD ^@ http://purl.uniprot.org/uniprot/A0A6P3E7V9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the zinc-containing alcohol dehydrogenase family.|||Binds 1 or 2 Zn(2+) ions per subunit.|||Homotetramer.|||Mitochondrion membrane|||Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||flagellum http://togogenome.org/gene/9940:LOC101103474 ^@ http://purl.uniprot.org/uniprot/W5Q3S6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:LOC101115226 ^@ http://purl.uniprot.org/uniprot/W5NT84 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/9940:TAF7 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE47|||http://purl.uniprot.org/uniprot/W5PXG1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRAM1L1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDJ5|||http://purl.uniprot.org/uniprot/W5NQ10 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:THADA ^@ http://purl.uniprot.org/uniprot/W5PAY3 ^@ Similarity ^@ Belongs to the THADA family. http://togogenome.org/gene/9940:COQ5 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENQ5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PTMA ^@ http://purl.uniprot.org/uniprot/A0A6P3TJX9|||http://purl.uniprot.org/uniprot/A0A6P3YK54 ^@ Caution|||Similarity ^@ Belongs to the pro/parathymosin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDC25C ^@ http://purl.uniprot.org/uniprot/W5Q3S7 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/9940:AKIRIN1 ^@ http://purl.uniprot.org/uniprot/B2ZEZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/9940:LOC101121883 ^@ http://purl.uniprot.org/uniprot/A0A6P3T572 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZNF852 ^@ http://purl.uniprot.org/uniprot/A0A6P3YNV4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SNRPC ^@ http://purl.uniprot.org/uniprot/W5PMC7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/9940:APOC2 ^@ http://purl.uniprot.org/uniprot/A0A6P7ET07 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C2 family.|||Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CR2 ^@ http://purl.uniprot.org/uniprot/O46545 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:UBB ^@ http://purl.uniprot.org/uniprot/P0CG55 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ubiquitin family.|||Cytoplasm|||Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.|||For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.|||Interacts with SKP1-KMD2A and SKP1-KMD2B complexes.|||Mitochondrion outer membrane|||Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.|||Nucleus|||Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy. Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30.|||Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. http://togogenome.org/gene/9940:LOC101102990 ^@ http://purl.uniprot.org/uniprot/A0A6P3TH10|||http://purl.uniprot.org/uniprot/A0A6P7DS65 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic10 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Membrane|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KIF2B ^@ http://purl.uniprot.org/uniprot/W5PVV1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9940:MAPRE2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFZ9|||http://purl.uniprot.org/uniprot/W5P6Z6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytoskeleton http://togogenome.org/gene/9940:PRND ^@ http://purl.uniprot.org/uniprot/A0A835ZVR1|||http://purl.uniprot.org/uniprot/A7U7P0|||http://purl.uniprot.org/uniprot/Q9GJY2 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ A short helical region is required and sufficient for Cu(2+) binding.|||Belongs to the prion family.|||Cell membrane|||Membrane|||N-glycosylated.|||O-glycosylated.|||Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity).|||Strongly expressed in testis. Detected at low levels in lymph node, spleen and ovary.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RORB ^@ http://purl.uniprot.org/uniprot/A0A6P3CX41|||http://purl.uniprot.org/uniprot/B3F205 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AURKA ^@ http://purl.uniprot.org/uniprot/B7U174 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||centrosome http://togogenome.org/gene/9940:LOC101108778 ^@ http://purl.uniprot.org/uniprot/A0A8N7XJ60 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCR10/QCR9 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101110617 ^@ http://purl.uniprot.org/uniprot/W5PCD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:CDX1 ^@ http://purl.uniprot.org/uniprot/W5P9Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/9940:CLTB ^@ http://purl.uniprot.org/uniprot/A0A6P3E5R3|||http://purl.uniprot.org/uniprot/W5NVY3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||coated pit http://togogenome.org/gene/9940:DERL2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EH25|||http://purl.uniprot.org/uniprot/W5NYS4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RAD51 ^@ http://purl.uniprot.org/uniprot/A0A6P7EB86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Nucleus|||Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair. http://togogenome.org/gene/9940:MRPL19 ^@ http://purl.uniprot.org/uniprot/A0A6P3E789|||http://purl.uniprot.org/uniprot/W5NSA9 ^@ Caution|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FUT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EK11 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 11 family.|||Golgi stack membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FABP7 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFP0|||http://purl.uniprot.org/uniprot/A0A6P7DE44 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101113108 ^@ http://purl.uniprot.org/uniprot/A0A835ZVL9 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BTG2 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQT1|||http://purl.uniprot.org/uniprot/F4MJ45 ^@ Caution|||Similarity ^@ Belongs to the BTG family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KDR ^@ http://purl.uniprot.org/uniprot/W5NSG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:CLDN18 ^@ http://purl.uniprot.org/uniprot/W5PCV1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9940:GJA5 ^@ http://purl.uniprot.org/uniprot/W5PRE6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9940:LOC101106492 ^@ http://purl.uniprot.org/uniprot/A0A836D957 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/9940:FAM118B ^@ http://purl.uniprot.org/uniprot/A0A6P7DA77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM118 family.|||Cajal body|||May play a role in Cajal bodies formation. http://togogenome.org/gene/9940:BNIPL ^@ http://purl.uniprot.org/uniprot/A0A6P3E4E2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KIFC1 ^@ http://purl.uniprot.org/uniprot/A0A835ZSA0 ^@ Caution|||Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FMO1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB41|||http://purl.uniprot.org/uniprot/W5PSR9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ADAM10 ^@ http://purl.uniprot.org/uniprot/W5QI59 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||adherens junction http://togogenome.org/gene/9940:LEO1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E694|||http://purl.uniprot.org/uniprot/W5QIH1 ^@ Caution|||Similarity ^@ Belongs to the LEO1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101106201 ^@ http://purl.uniprot.org/uniprot/A0A6P3EL57 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GDE1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQR0|||http://purl.uniprot.org/uniprot/W5PQZ5 ^@ Caution|||Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101119090 ^@ http://purl.uniprot.org/uniprot/A0A836D7W6|||http://purl.uniprot.org/uniprot/W5PMU0 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:P2RY6 ^@ http://purl.uniprot.org/uniprot/A0A6P3YLV3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC105610402 ^@ http://purl.uniprot.org/uniprot/A0A835ZJ51|||http://purl.uniprot.org/uniprot/K4P217 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL22 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TM9SF1 ^@ http://purl.uniprot.org/uniprot/A0A836A557 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C24H7orf61 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEA7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CHML ^@ http://purl.uniprot.org/uniprot/A0A6P3TLQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. http://togogenome.org/gene/9940:C1D ^@ http://purl.uniprot.org/uniprot/A0A6P3E9V5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the C1D family.|||Cytoplasm|||Monomer and homodimer.|||Nucleus|||Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:FBLN7 ^@ http://purl.uniprot.org/uniprot/W5PYI0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:STAG1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TFQ1|||http://purl.uniprot.org/uniprot/W5PDD5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||centromere http://togogenome.org/gene/9940:PSMB5 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAT1|||http://purl.uniprot.org/uniprot/W5QDM2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ADRB3 ^@ http://purl.uniprot.org/uniprot/Q2XQ07|||http://purl.uniprot.org/uniprot/Q9XT58 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.|||Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.|||Cell membrane|||Interacts with ARRDC3.|||Membrane http://togogenome.org/gene/9940:SCUBE3 ^@ http://purl.uniprot.org/uniprot/W5PP71 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9940:SLC66A2 ^@ http://purl.uniprot.org/uniprot/A0A6P7DCQ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:ZBP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EF73 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KATNAL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TQW1 ^@ Activity Regulation|||Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||Cytoplasm|||Interacts with KATNB1 and KATNBL1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Midbody|||Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.|||Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.|||The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.|||Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9940:ARRDC3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E690 ^@ Caution|||Similarity ^@ Belongs to the arrestin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPL22L1 ^@ http://purl.uniprot.org/uniprot/A0A6P7EL92 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HOMEZ ^@ http://purl.uniprot.org/uniprot/W5QDI1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:STAM2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8P9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GFUS ^@ http://purl.uniprot.org/uniprot/A0A836CZ08|||http://purl.uniprot.org/uniprot/W5Q563 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.|||Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RHOA ^@ http://purl.uniprot.org/uniprot/A0A6P9FQL7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IMMT ^@ http://purl.uniprot.org/uniprot/W5QHI0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic60 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9940:GJC1 ^@ http://purl.uniprot.org/uniprot/A0A6P7EG46 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with CNST.|||Belongs to the connexin family. Gamma-type subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9940:RCL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E899|||http://purl.uniprot.org/uniprot/W5PVF0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.|||Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:RANGRF ^@ http://purl.uniprot.org/uniprot/A0A6P3EA34|||http://purl.uniprot.org/uniprot/W5NQU3 ^@ Caution|||Similarity ^@ Belongs to the MOG1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SNAP23 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEY0|||http://purl.uniprot.org/uniprot/W5QH64 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||synaptosome http://togogenome.org/gene/9940:CD14 ^@ http://purl.uniprot.org/uniprot/Q06AV9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.|||Cell membrane|||Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).|||Golgi apparatus|||Membrane|||Membrane raft|||Secreted http://togogenome.org/gene/9940:B3GALT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YK02|||http://purl.uniprot.org/uniprot/W5QEG7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BGLAP ^@ http://purl.uniprot.org/uniprot/Q1ZZ82 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the osteocalcin/matrix Gla protein family.|||Binds strongly to apatite and calcium.|||Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.|||Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.|||Secreted http://togogenome.org/gene/9940:POLR1H ^@ http://purl.uniprot.org/uniprot/A0A6P3EF08 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:UPRT ^@ http://purl.uniprot.org/uniprot/A0A6P3EN25 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RNF113A ^@ http://purl.uniprot.org/uniprot/A0A835ZJY2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC24A5 ^@ http://purl.uniprot.org/uniprot/G3FHC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9940:TRMT12 ^@ http://purl.uniprot.org/uniprot/A0A835ZYL6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MYOZ1 ^@ http://purl.uniprot.org/uniprot/W5PDD8 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9940:VPS45 ^@ http://purl.uniprot.org/uniprot/A0A6P3E720 ^@ Caution|||Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KLHL7 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4K3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SHMT2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TJZ7 ^@ Caution|||Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DDIAS ^@ http://purl.uniprot.org/uniprot/A0A835ZWV3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GABRB2 ^@ http://purl.uniprot.org/uniprot/I2BJM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9940:ADAL ^@ http://purl.uniprot.org/uniprot/A0A6P3EEB8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UTP11 ^@ http://purl.uniprot.org/uniprot/A0A6P3T804|||http://purl.uniprot.org/uniprot/W5QFC5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:CHCHD3 ^@ http://purl.uniprot.org/uniprot/A0A6P3CWZ0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101115495 ^@ http://purl.uniprot.org/uniprot/W5PD71 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9940:SMCO3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3E6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ACTRT2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EI47|||http://purl.uniprot.org/uniprot/W5P561 ^@ Caution|||Similarity ^@ Belongs to the actin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POLR2B ^@ http://purl.uniprot.org/uniprot/A0A6P3E6X2 ^@ Caution|||Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TACSTD2 ^@ http://purl.uniprot.org/uniprot/A0A6P3ET79 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPCAM family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101112889 ^@ http://purl.uniprot.org/uniprot/A0A6P3YU72 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PDC ^@ http://purl.uniprot.org/uniprot/W5PC40 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9940:LOC101102809 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5S2|||http://purl.uniprot.org/uniprot/W5P7D5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RASL11B ^@ http://purl.uniprot.org/uniprot/A0A6P3EF44 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CXCL1 ^@ http://purl.uniprot.org/uniprot/O46678 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Has chemotactic activity for neutrophils.|||Secreted http://togogenome.org/gene/9940:SNX5 ^@ http://purl.uniprot.org/uniprot/A0A6P3TJB7|||http://purl.uniprot.org/uniprot/A0A6P7EW54 ^@ Caution|||Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DRAM2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5H8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:PRPS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TG37 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RAB21 ^@ http://purl.uniprot.org/uniprot/C5IJ97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cleavage furrow|||Cytoplasmic vesicle membrane|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||neuron projection|||trans-Golgi network http://togogenome.org/gene/9940:NEUROD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TCD6 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UBE2B ^@ http://purl.uniprot.org/uniprot/W5PWV6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9940:SELENOI ^@ http://purl.uniprot.org/uniprot/W5QBR4 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/9940:DHRS7 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB99|||http://purl.uniprot.org/uniprot/W5QJ03 ^@ Caution|||Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SENP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TGE4|||http://purl.uniprot.org/uniprot/W5QH92 ^@ Caution|||Similarity ^@ Belongs to the peptidase C48 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MARVELD2 ^@ http://purl.uniprot.org/uniprot/W5P6E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9940:LOC101104297 ^@ http://purl.uniprot.org/uniprot/W5QED4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TTC30/dfy-1/fleer family.|||Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.|||cilium http://togogenome.org/gene/9940:TMEM98 ^@ http://purl.uniprot.org/uniprot/A0A6P3YJZ5|||http://purl.uniprot.org/uniprot/W5PJS3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM98 family.|||Endoplasmic reticulum membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||extracellular exosome http://togogenome.org/gene/9940:G6PC1 ^@ http://purl.uniprot.org/uniprot/W5P1N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9940:DSC2 ^@ http://purl.uniprot.org/uniprot/W5PA25 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/9940:MTOR ^@ http://purl.uniprot.org/uniprot/B9VXW5 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. http://togogenome.org/gene/9940:MANF ^@ http://purl.uniprot.org/uniprot/A0A6P3EIS3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARMET family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SEPHS2 ^@ http://purl.uniprot.org/uniprot/A0A835ZMN2 ^@ Caution|||Function ^@ Synthesizes selenophosphate from selenide and ATP.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRDX5 ^@ http://purl.uniprot.org/uniprot/W5PAL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxiredoxin family. Prx5 subfamily.|||Peroxisome matrix|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. http://togogenome.org/gene/9940:DCAF16 ^@ http://purl.uniprot.org/uniprot/A0A6P3TEM4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OVGP1 ^@ http://purl.uniprot.org/uniprot/Q28542 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the glycosyl hydrolase 18 family.|||Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.|||Levels are highest in the fimbria and ampulla at estrus and on day 1 of pregnancy, when gamete transport and fertilization occurs in the E2-dominated fallopian tube. Levels decline significantly on day 2 and undergo a further significant reduction on day 3 of pregnancy coincident with transport of the embryo from the oviduct to the uterus, a reproductive stage associated with rising progesterone levels.|||Oviduct.|||secretory vesicle http://togogenome.org/gene/9940:INSIG1 ^@ http://purl.uniprot.org/uniprot/W5P9G9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/9940:ATXN1L ^@ http://purl.uniprot.org/uniprot/A0A6P3EC94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATXN1 family.|||Nucleus http://togogenome.org/gene/9940:MPV17L ^@ http://purl.uniprot.org/uniprot/A0A6P3EGA2|||http://purl.uniprot.org/uniprot/A0A6P7DFF3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OXCT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ELR7|||http://purl.uniprot.org/uniprot/W5PGM1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 3-oxoacid CoA-transferase family.|||Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.|||Mitochondrion|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARL6IP5 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEI4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SSTR2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAM9|||http://purl.uniprot.org/uniprot/W5NPT8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).|||Membrane|||Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PEX13 ^@ http://purl.uniprot.org/uniprot/A0A6P3E2L7|||http://purl.uniprot.org/uniprot/W5NT51 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-13 family.|||Membrane|||Peroxisome membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CORO2A ^@ http://purl.uniprot.org/uniprot/W5PN93 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9940:LOC101112761 ^@ http://purl.uniprot.org/uniprot/A0A835ZUG2|||http://purl.uniprot.org/uniprot/W5PTD8 ^@ Caution|||Similarity ^@ Belongs to the MS4A family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM138 ^@ http://purl.uniprot.org/uniprot/W5PTH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM138 family.|||Membrane|||Required for ciliogenesis.|||Vacuole membrane|||cilium http://togogenome.org/gene/9940:GNAI1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YHI7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BMP7 ^@ http://purl.uniprot.org/uniprot/W8E0V8 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9940:UCHL5 ^@ http://purl.uniprot.org/uniprot/W5PIL6 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/9940:JUN ^@ http://purl.uniprot.org/uniprot/W5PJV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/9940:SLC7A2 ^@ http://purl.uniprot.org/uniprot/W5PHN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:TMC7 ^@ http://purl.uniprot.org/uniprot/W5PPW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/9940:PDE4C ^@ http://purl.uniprot.org/uniprot/W5PTV4 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9940:TP53I11 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAL6 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RDX ^@ http://purl.uniprot.org/uniprot/W5PUV9 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton|||microvillus http://togogenome.org/gene/9940:TIMM10 ^@ http://purl.uniprot.org/uniprot/A0A6P3T5K1|||http://purl.uniprot.org/uniprot/A0A6P3TFS9 ^@ Caution|||Function ^@ Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPS26 ^@ http://purl.uniprot.org/uniprot/Q6Q312 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS26 family.|||Component of the 40S small ribosomal subunit.|||Cytoplasm|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/9940:LOC101102419 ^@ http://purl.uniprot.org/uniprot/W5PB32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:NCAPH ^@ http://purl.uniprot.org/uniprot/A0A6P3YGT1|||http://purl.uniprot.org/uniprot/W5PWU1|||http://purl.uniprot.org/uniprot/W5PWV2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CND2 (condensin subunit 2) family.|||Belongs to the ITPRIP family.|||Chromosome|||Cytoplasm|||Membrane|||Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. http://togogenome.org/gene/9940:ALOX12 ^@ http://purl.uniprot.org/uniprot/W5PHM1 ^@ Caution|||Similarity ^@ Belongs to the lipoxygenase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:TAS2R3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TD64|||http://purl.uniprot.org/uniprot/W5NSX0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:VGLL1 ^@ http://purl.uniprot.org/uniprot/W5PN86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs.|||Nucleus http://togogenome.org/gene/9940:LECT2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4S0 ^@ Caution|||Similarity ^@ Belongs to the LECT2/MIM-1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101105957 ^@ http://purl.uniprot.org/uniprot/W5Q1X0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:NCK1 ^@ http://purl.uniprot.org/uniprot/A0A6P3T7V1|||http://purl.uniprot.org/uniprot/A0A6P3TI97|||http://purl.uniprot.org/uniprot/C8BKC6 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NANOS2 ^@ http://purl.uniprot.org/uniprot/W5PPB5 ^@ Similarity ^@ Belongs to the nanos family. http://togogenome.org/gene/9940:GABRA2 ^@ http://purl.uniprot.org/uniprot/W5Q1N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/9940:LOC101116273 ^@ http://purl.uniprot.org/uniprot/A0A6P3TDI6|||http://purl.uniprot.org/uniprot/W5PC25 ^@ Caution|||Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SFTPB ^@ http://purl.uniprot.org/uniprot/A0A6P3TP46 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KNCN ^@ http://purl.uniprot.org/uniprot/A0A6P3DYQ3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATG4C ^@ http://purl.uniprot.org/uniprot/A0A6P3E6E4|||http://purl.uniprot.org/uniprot/A0A836D6I5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARMH3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQ30 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TEX43 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9E8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LRRC17 ^@ http://purl.uniprot.org/uniprot/A0A6P3E407 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GNPDA2 ^@ http://purl.uniprot.org/uniprot/W5Q0A8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/9940:EHF ^@ http://purl.uniprot.org/uniprot/W5QBF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9940:HSDL2 ^@ http://purl.uniprot.org/uniprot/W5P972 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9940:PR ^@ http://purl.uniprot.org/uniprot/O46561 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Expressed in all tissues examined; liver, pituitary, adrenal gland, ovary and fetal liver.|||Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.|||Membrane|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation.|||This is a receptor for the anterior pituitary hormone prolactin. http://togogenome.org/gene/9940:LOC101114959 ^@ http://purl.uniprot.org/uniprot/W5PTZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9940:ASPA ^@ http://purl.uniprot.org/uniprot/W5Q5Q7 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9940:LIPC ^@ http://purl.uniprot.org/uniprot/A0A6P3E7R6|||http://purl.uniprot.org/uniprot/A0A6P3TQV8 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SERINC5 ^@ http://purl.uniprot.org/uniprot/A0A6P3TQB2|||http://purl.uniprot.org/uniprot/W5Q7V8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101116443 ^@ http://purl.uniprot.org/uniprot/A0A6P3E566 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UBA52 ^@ http://purl.uniprot.org/uniprot/A0A836D2E6|||http://purl.uniprot.org/uniprot/P0C276 ^@ Caution|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs.|||Cytoplasm|||Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.|||Nucleus|||Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy. Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30.|||Ribosomal protein L40 is part of the 60S ribosomal subunit. Interacts with UBQLN1 (via UBA domain).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. http://togogenome.org/gene/9940:ZNF570 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9R5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SUPT4H1 ^@ http://purl.uniprot.org/uniprot/A0A6P7EMC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT4 family.|||Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.|||Nucleus http://togogenome.org/gene/9940:TRAPPC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EH65|||http://purl.uniprot.org/uniprot/W5QAA8 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cis-Golgi network http://togogenome.org/gene/9940:DMAC2L ^@ http://purl.uniprot.org/uniprot/W5QHH7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATP synthase subunit s family.|||Homotetramer. Associates with ATP synthase.|||Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9940:GFM2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB08 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.|||Mitochondrion|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PGFS ^@ http://purl.uniprot.org/uniprot/A0A6P3E956 ^@ Caution|||Similarity ^@ Belongs to the aldo/keto reductase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BGN ^@ http://purl.uniprot.org/uniprot/O46390 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||Found in several connective tissues, especially in articular cartilages.|||Homodimer. Forms a ternary complex with MFAP2 and ELN (By similarity).|||May be involved in collagen fiber assembly.|||The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.|||extracellular matrix http://togogenome.org/gene/9940:INSL6 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5Z7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||May have a role in sperm development and fertilization.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MSANTD3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YJJ3 ^@ Similarity ^@ Belongs to the MSANTD3 family. http://togogenome.org/gene/9940:KIF15 ^@ http://purl.uniprot.org/uniprot/W5P3X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||spindle http://togogenome.org/gene/9940:MRPS7 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8C2|||http://purl.uniprot.org/uniprot/W5PMH5 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uS7 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RNF185 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE49 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ITGAX ^@ http://purl.uniprot.org/uniprot/D6BMU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9940:DDX55 ^@ http://purl.uniprot.org/uniprot/W5NZJ4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9940:CAVIN2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E1I7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||caveola http://togogenome.org/gene/9940:IL18R1 ^@ http://purl.uniprot.org/uniprot/W5PU94 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9940:RAN ^@ http://purl.uniprot.org/uniprot/A0A6P9FQL0|||http://purl.uniprot.org/uniprot/C5IJA0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ran family.|||GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TPM4 ^@ http://purl.uniprot.org/uniprot/W5NRW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9940:NGDN ^@ http://purl.uniprot.org/uniprot/A0A6P3E7B3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CBX3 ^@ http://purl.uniprot.org/uniprot/A0A836AE85 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HMGCS2 ^@ http://purl.uniprot.org/uniprot/W5QGT9 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/9940:SLC30A9 ^@ http://purl.uniprot.org/uniprot/W5PX15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Cytoplasmic vesicle|||Endoplasmic reticulum|||Membrane|||Nucleus|||Vesicle http://togogenome.org/gene/9940:ZSCAN30 ^@ http://purl.uniprot.org/uniprot/W5P6Q2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:LOC101107252 ^@ http://purl.uniprot.org/uniprot/A0A835ZK36 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HDAC9 ^@ http://purl.uniprot.org/uniprot/F8SRE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus http://togogenome.org/gene/9940:FGF12 ^@ http://purl.uniprot.org/uniprot/C5ISA5 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9940:ZDHHC15 ^@ http://purl.uniprot.org/uniprot/A0A6P3ESJ6|||http://purl.uniprot.org/uniprot/W5QA46 ^@ Caution|||Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101121371 ^@ http://purl.uniprot.org/uniprot/W5Q6M1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/9940:PRDX6 ^@ http://purl.uniprot.org/uniprot/A0A6P3CY24|||http://purl.uniprot.org/uniprot/M4T8F1 ^@ Caution|||Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9940:TRIP12 ^@ http://purl.uniprot.org/uniprot/A0A6P3YG59 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPL family. K-HECT subfamily.|||E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleoplasm http://togogenome.org/gene/9940:LOC101111875 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8L6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RETREG1 ^@ http://purl.uniprot.org/uniprot/A0A1Y0BRK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Membrane http://togogenome.org/gene/9940:LOC101118444 ^@ http://purl.uniprot.org/uniprot/A0A836AG41|||http://purl.uniprot.org/uniprot/W5NTR3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GDF15 ^@ http://purl.uniprot.org/uniprot/W5PSA2 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9940:FRZB ^@ http://purl.uniprot.org/uniprot/A0A6P7DPG8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. http://togogenome.org/gene/9940:SPRN ^@ http://purl.uniprot.org/uniprot/A6XN32|||http://purl.uniprot.org/uniprot/C6ETC1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the SPRN family.|||Cell membrane|||Mainly expressed in brain.|||N-glycosylated.|||Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).|||Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP. http://togogenome.org/gene/9940:CDK5 ^@ http://purl.uniprot.org/uniprot/B6E1W2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9940:PSMA3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EG85|||http://purl.uniprot.org/uniprot/W5QIY3 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AP3S1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YJX3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Membrane|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PSMD7 ^@ http://purl.uniprot.org/uniprot/A0A6P3EL50|||http://purl.uniprot.org/uniprot/W5P0D5 ^@ Caution|||Similarity ^@ Belongs to the peptidase M67A family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ADGB ^@ http://purl.uniprot.org/uniprot/W5NW73 ^@ Caution|||Similarity ^@ Belongs to the peptidase C2 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:AGK ^@ http://purl.uniprot.org/uniprot/A0A6P7E2Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AGK family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9940:CFL1 ^@ http://purl.uniprot.org/uniprot/Q6B7M7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin-binding proteins ADF family.|||Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (By similarity). Important for normal progress through mitosis and normal cytokinesis (By similarity). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). Required for neural tube morphogenesis and neural crest cell migration (By similarity).|||Can bind G- and F-actin in a 1:1 ratio of cofilin to actin (By similarity). It is a major component of intranuclear and cytoplasmic actin rods (By similarity). Interacts with the subcortical maternal complex (SCMC) via interaction with TLE6 and NLRP5 (By similarity). Interacts with C9orf72 (By similarity).|||Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells (By similarity). Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal (By similarity). Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor ACKR2 (By similarity).|||Nucleus matrix|||axon|||cytoskeleton|||growth cone|||lamellipodium|||lamellipodium membrane|||ruffle membrane http://togogenome.org/gene/9940:MYF6 ^@ http://purl.uniprot.org/uniprot/B5LZ29 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:LOC101101934 ^@ http://purl.uniprot.org/uniprot/A0A835ZP88|||http://purl.uniprot.org/uniprot/W5Q1E5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DEGS1 ^@ http://purl.uniprot.org/uniprot/B6UV64 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.|||Membrane http://togogenome.org/gene/9940:PPIP5K2 ^@ http://purl.uniprot.org/uniprot/W5QAX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family. VIP1 subfamily.|||Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).|||cytosol http://togogenome.org/gene/9940:ADM ^@ http://purl.uniprot.org/uniprot/A0A6P7EY83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adrenomedullin family.|||Belongs to the calcitonin family.|||Secreted http://togogenome.org/gene/9940:SFRP2 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQI7|||http://purl.uniprot.org/uniprot/C5IWT3 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STRADB ^@ http://purl.uniprot.org/uniprot/A0A6P3E6H2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101105290 ^@ http://purl.uniprot.org/uniprot/A0A836CVN3|||http://purl.uniprot.org/uniprot/W5QGB5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EEF1AKMT3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBT1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KLHL11 ^@ http://purl.uniprot.org/uniprot/A0A836A8J4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101116843 ^@ http://purl.uniprot.org/uniprot/A0A6P7DGY8 ^@ Caution|||Function|||Similarity ^@ Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CYP2A6 ^@ http://purl.uniprot.org/uniprot/W5PB29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9940:LIN37 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJM4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101114861 ^@ http://purl.uniprot.org/uniprot/W5Q6I2 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the CD36 family.|||Cell membrane|||Golgi apparatus|||Membrane|||Membrane raft http://togogenome.org/gene/9940:ZHX1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YJE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/9940:SMARCB1 ^@ http://purl.uniprot.org/uniprot/W5PUS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF5 family.|||Nucleus http://togogenome.org/gene/9940:PLEK2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGB6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PHKA2 ^@ http://purl.uniprot.org/uniprot/A0A6P3ERT0 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101121728 ^@ http://purl.uniprot.org/uniprot/A0A836D7D9|||http://purl.uniprot.org/uniprot/W5P909 ^@ Caution|||Similarity ^@ Belongs to the LCE family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101119218 ^@ http://purl.uniprot.org/uniprot/W5Q8V6 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9940:LOC101117021 ^@ http://purl.uniprot.org/uniprot/A0A835ZNH3 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STXBP5L ^@ http://purl.uniprot.org/uniprot/W5QFF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9940:MDFIC ^@ http://purl.uniprot.org/uniprot/W5NUJ3 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/9940:NDUFV3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7B5 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.|||Belongs to the complex I NDUFV3 subunit family.|||Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. http://togogenome.org/gene/9940:IFT172 ^@ http://purl.uniprot.org/uniprot/A0A6P3E265 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:INHBE ^@ http://purl.uniprot.org/uniprot/W5PA02 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9940:SAT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ERT4|||http://purl.uniprot.org/uniprot/W5Q5Q0 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the acetyltransferase family.|||Homodimer.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FBXO8 ^@ http://purl.uniprot.org/uniprot/A0A6P3E1G2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATP5F1A ^@ http://purl.uniprot.org/uniprot/A0A8N7XJ64 ^@ Caution|||Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MATR3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TSH3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TFPI2 ^@ http://purl.uniprot.org/uniprot/W5NS10 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9940:LRRC4C ^@ http://purl.uniprot.org/uniprot/A0A6P3EGR9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CALM2 ^@ http://purl.uniprot.org/uniprot/A0A6P7ECH5|||http://purl.uniprot.org/uniprot/Q6YNX6 ^@ Caution|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calmodulin family.|||Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Is a regulator of voltage-dependent L-type calcium channels. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2. Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding. Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2.|||Interacts with CEP97, CCP110, TTN/titin and SRY. Interacts with MYO5A and RRAD (By similarity). Interacts with USP6; the interaction is calcium dependent (By similarity). Interacts with CDK5RAP2. Interacts with SCN5A. Interacts with RYR1 and RYR2 (By similarity). Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure. Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport. Interacts with SYT7 (By similarity). Interacts with MYO10 and MYO1C (By similarity). Interacts with SLC9A1 in a calcium-dependent manner (By similarity). Interacts with HINT1; interaction increases in the presence of calcium ions (By similarity). Interacts with HINT3 (By similarity).|||Phosphorylation results in a decreased activity.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||This protein has four functional calcium-binding sites.|||Ubiquitination results in a strongly decreased activity.|||spindle|||spindle pole http://togogenome.org/gene/9940:MAPKAPK3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YRQ3|||http://purl.uniprot.org/uniprot/W5PFH4 ^@ Caution|||Similarity ^@ Belongs to the protein kinase superfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HACE1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBS0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SRA1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE36 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NOG ^@ http://purl.uniprot.org/uniprot/D3U2P7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the noggin family.|||Homodimer.|||Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.|||Secreted http://togogenome.org/gene/9940:DCAF12 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8Y6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:G6PD ^@ http://purl.uniprot.org/uniprot/A1XI86 ^@ Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. http://togogenome.org/gene/9940:B2M ^@ http://purl.uniprot.org/uniprot/A4ZVY9|||http://purl.uniprot.org/uniprot/Q6QAT4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta-2-microglobulin family.|||Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).|||Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).|||Secreted http://togogenome.org/gene/9940:CRBN ^@ http://purl.uniprot.org/uniprot/A0A6P3EEI3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRBN family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAAH ^@ http://purl.uniprot.org/uniprot/A0A6P3E3X1|||http://purl.uniprot.org/uniprot/W5NWR9 ^@ Caution|||Similarity ^@ Belongs to the amidase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CTH ^@ http://purl.uniprot.org/uniprot/A0A6P3E429|||http://purl.uniprot.org/uniprot/W5PQY2 ^@ Caution|||Similarity ^@ Belongs to the trans-sulfuration enzymes family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPL21 ^@ http://purl.uniprot.org/uniprot/A0A6P3YJN3 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARPP19 ^@ http://purl.uniprot.org/uniprot/A0A836A5U0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CTDSP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3T9G5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CALR3 ^@ http://purl.uniprot.org/uniprot/A0A836A2S3|||http://purl.uniprot.org/uniprot/W5QCE1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calreticulin family.|||Endoplasmic reticulum lumen|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRPL52 ^@ http://purl.uniprot.org/uniprot/W5QDR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL52 family.|||Mitochondrion http://togogenome.org/gene/9940:CHST12 ^@ http://purl.uniprot.org/uniprot/A0A6P3YPA0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HAND1 ^@ http://purl.uniprot.org/uniprot/Q28555 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein. Forms homodimers and heterodimers with TCF3 gene products E12 and E47, HAND2 and HEY1, HEY2 and HEYL (hairy-related transcription factors). Interacts with MDFIC (By similarity). Interacts with SOX15; the interaction enhances HAND1-induced differentiation of trophoblast giant cells (By similarity).|||Phosphorylation by PLK4 disrupts the interaction with MDFIC and leads to translocation into the nucleoplasm, allowing dimerization and transcription factor activity.|||Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity).|||nucleolus|||nucleoplasm http://togogenome.org/gene/9940:PNOC ^@ http://purl.uniprot.org/uniprot/A0A6P7DNQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Secreted http://togogenome.org/gene/9940:GPR173 ^@ http://purl.uniprot.org/uniprot/A0A6P3TAX7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MAGI3 ^@ http://purl.uniprot.org/uniprot/W5QEY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9940:LOC101119281 ^@ http://purl.uniprot.org/uniprot/A0A6P3EN93|||http://purl.uniprot.org/uniprot/W5PIZ5 ^@ Caution|||Similarity ^@ Belongs to the actin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KLHL20 ^@ http://purl.uniprot.org/uniprot/A0A836A754 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HDAC2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBP1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ENO3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TWQ3|||http://purl.uniprot.org/uniprot/W5P663 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZNF280D ^@ http://purl.uniprot.org/uniprot/A0A6P3YIW9|||http://purl.uniprot.org/uniprot/A0A6P3YIY6 ^@ Caution|||Function|||Subcellular Location Annotation ^@ May function as a transcription factor.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101119679 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJI1|||http://purl.uniprot.org/uniprot/A0A836CTR2 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FGD1 ^@ http://purl.uniprot.org/uniprot/W5P8R2 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9940:SNF8 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDC2|||http://purl.uniprot.org/uniprot/W5P9G5 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the SNF8 family.|||Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101111190 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4Y6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SNAP25 ^@ http://purl.uniprot.org/uniprot/W5PKN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.|||Photoreceptor inner segment|||synaptosome|||t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. http://togogenome.org/gene/9940:LOC101115420 ^@ http://purl.uniprot.org/uniprot/W5PWG8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9940:GLDN ^@ http://purl.uniprot.org/uniprot/A0A6P3E697|||http://purl.uniprot.org/uniprot/W5QII9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC25A51 ^@ http://purl.uniprot.org/uniprot/A0A6P3E932|||http://purl.uniprot.org/uniprot/A0A6P3TBX8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MAK16 ^@ http://purl.uniprot.org/uniprot/W5NQE1 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/9940:SCAMP3 ^@ http://purl.uniprot.org/uniprot/W5P1K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9940:PSMD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YGA1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S1 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM184C ^@ http://purl.uniprot.org/uniprot/W5PDM6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:ITGB2 ^@ http://purl.uniprot.org/uniprot/Q6ECI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Heterodimer of an alpha and a beta subunit. The ITGB2 beta subunit associates with the ITGAL, ITGAM, ITGAX or ITGAD alpha subunits. Found in a complex with CD177 and ITGAM/CD11b. Interacts with FGR. Interacts with COPS5 and RANBP9. Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23). Interacts with THBD.|||Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils.|||Membrane raft http://togogenome.org/gene/9940:HSPB3 ^@ http://purl.uniprot.org/uniprot/W5P6E2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/9940:FTCDNL1 ^@ http://purl.uniprot.org/uniprot/A0A836D757 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RCAN1 ^@ http://purl.uniprot.org/uniprot/Q6XXM7 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the RCAN family.|||Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.|||Interacts with RAF1, PPP3R1 and PPP3CA.|||Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life. http://togogenome.org/gene/9940:KRT25 ^@ http://purl.uniprot.org/uniprot/Q9BGM5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the intermediate filament family.|||Cytoplasm|||Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (By similarity).|||Expressed in skin and wool follicle. Expression localized to the inner root sheath of wool follicle.|||Heterodimer of a type I and a type II keratin. Heterodimer with type II keratin KRT5 leading to the formation of keratin intermediate filament (KIF) network. Interacts with KRT6A to form filaments.|||There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). http://togogenome.org/gene/9940:DNAH12 ^@ http://purl.uniprot.org/uniprot/W5PWU4 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/9940:MAGT1 ^@ http://purl.uniprot.org/uniprot/W5QAQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9940:MALL ^@ http://purl.uniprot.org/uniprot/W5PXT6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:OXR1 ^@ http://purl.uniprot.org/uniprot/W5Q149 ^@ Similarity ^@ Belongs to the OXR1 family. http://togogenome.org/gene/9940:TIMM8A ^@ http://purl.uniprot.org/uniprot/A0A6P3EFD6|||http://purl.uniprot.org/uniprot/W5NU43 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9940:STC1 ^@ http://purl.uniprot.org/uniprot/W5PJZ9 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9940:LAMTOR2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E640 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GAMAD family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NRP2 ^@ http://purl.uniprot.org/uniprot/W5QAQ4 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:HOOK1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YEY9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hook family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytoskeleton http://togogenome.org/gene/9940:KIN ^@ http://purl.uniprot.org/uniprot/W5PWH7 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/9940:MAGOH ^@ http://purl.uniprot.org/uniprot/A0A6P3DYT4|||http://purl.uniprot.org/uniprot/A0A6P7DNV8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCNT2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TCN8|||http://purl.uniprot.org/uniprot/W5PNN9 ^@ Caution|||Similarity ^@ Belongs to the cyclin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC35F6 ^@ http://purl.uniprot.org/uniprot/W5QCF3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLC35F solute transporter family.|||Interacts with SLC25A5.|||May play a role as a nucleotide-sugar transporter.|||Membrane|||Mitochondrion http://togogenome.org/gene/9940:METTL8 ^@ http://purl.uniprot.org/uniprot/W5NVW6 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9940:PSMA4 ^@ http://purl.uniprot.org/uniprot/W5NS93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9940:C14H16orf46 ^@ http://purl.uniprot.org/uniprot/A0A6P7EUC7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NUP35 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9J6|||http://purl.uniprot.org/uniprot/W5Q5H5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nup35 family.|||Functions as a component of the nuclear pore complex (NPC).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nuclear pore complex http://togogenome.org/gene/9940:ICOS ^@ http://purl.uniprot.org/uniprot/W5QAC8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/9940:ASB15 ^@ http://purl.uniprot.org/uniprot/A0A6P3E543 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLCO1C1 ^@ http://purl.uniprot.org/uniprot/W5QGV2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9940:CAPN6 ^@ http://purl.uniprot.org/uniprot/W5Q8J4 ^@ Caution|||Similarity ^@ Belongs to the peptidase C2 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:SMOX ^@ http://purl.uniprot.org/uniprot/A0A6P3EIR2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCNE2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TVS8 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin E subfamily. http://togogenome.org/gene/9940:ETF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YLJ4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HADHA ^@ http://purl.uniprot.org/uniprot/A0A6P9FQD3|||http://purl.uniprot.org/uniprot/B6UV59 ^@ Caution|||Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GAD2 ^@ http://purl.uniprot.org/uniprot/W5P462 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9940:FAM3C ^@ http://purl.uniprot.org/uniprot/A0A6P7E2I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9940:MRPL27 ^@ http://purl.uniprot.org/uniprot/A0A6P3E813|||http://purl.uniprot.org/uniprot/W5P3H6 ^@ Caution|||Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MAN1A2 ^@ http://purl.uniprot.org/uniprot/A0A6P3DYT8 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 47 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DAB2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TCK1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AKAP10 ^@ http://purl.uniprot.org/uniprot/A0A835ZWW1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IL15 ^@ http://purl.uniprot.org/uniprot/Q9XSJ6|||http://purl.uniprot.org/uniprot/W5PRB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines. In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection. Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5 (By similarity). In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (By similarity).|||Secreted http://togogenome.org/gene/9940:MCP-3 ^@ http://purl.uniprot.org/uniprot/O46683 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family. Granzyme subfamily.|||Cytoplasmic granule|||Secreted http://togogenome.org/gene/9940:TTPA ^@ http://purl.uniprot.org/uniprot/A0A6P9FRF9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CFAP43 ^@ http://purl.uniprot.org/uniprot/W5PA43 ^@ Similarity ^@ Belongs to the CFAP43 family. http://togogenome.org/gene/9940:PADI3 ^@ http://purl.uniprot.org/uniprot/O02849 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm|||Found in wool follicles, keratinizing epithelia of the ruminal mucosa, embryonic hoof and tongue filiform papillae.|||The N-terminus is blocked. http://togogenome.org/gene/9940:NUDT12 ^@ http://purl.uniprot.org/uniprot/A0A6P3TE95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Nudix hydrolase family. NudC subfamily.|||Cytoplasmic granule|||Peroxisome http://togogenome.org/gene/9940:C11H17orf58 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJ02 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EID1 ^@ http://purl.uniprot.org/uniprot/W5NS15 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:LAPTM5 ^@ http://purl.uniprot.org/uniprot/W5NVL1 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9940:AP5S1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EKG0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101121627 ^@ http://purl.uniprot.org/uniprot/W5P9I7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:SPTLC2 ^@ http://purl.uniprot.org/uniprot/W5NX59 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9940:TSPAN13 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBR7|||http://purl.uniprot.org/uniprot/W5PGM8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DOCK4 ^@ http://purl.uniprot.org/uniprot/A0A836AA49|||http://purl.uniprot.org/uniprot/W5NY92 ^@ Caution|||Similarity ^@ Belongs to the DOCK family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GRP ^@ http://purl.uniprot.org/uniprot/A0A836CR47|||http://purl.uniprot.org/uniprot/P47851 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bombesin/neuromedin-B/ranatensin family.|||Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation.|||Secreted|||Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (By similarity). Contributes primarily to nonhistaminergic itch sensation (By similarity). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories (By similarity). Contributes to the regulation of food intake (By similarity). Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||neuron projection|||secretory vesicle lumen http://togogenome.org/gene/9940:LOC101104530 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC08 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC106990122 ^@ http://purl.uniprot.org/uniprot/W5PMM4 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9940:LMO4 ^@ http://purl.uniprot.org/uniprot/A0A6P3E449 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HNRNPH2 ^@ http://purl.uniprot.org/uniprot/A0A6P3ESJ1|||http://purl.uniprot.org/uniprot/A0A6P3TBF0 ^@ Caution|||Subcellular Location Annotation ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleoplasm http://togogenome.org/gene/9940:SLC39A8 ^@ http://purl.uniprot.org/uniprot/W5PUQ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:RAD21 ^@ http://purl.uniprot.org/uniprot/W5PKY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/9940:ZNF449 ^@ http://purl.uniprot.org/uniprot/A0A6P3ESB7|||http://purl.uniprot.org/uniprot/A0A6P7DJT2 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC38A1 ^@ http://purl.uniprot.org/uniprot/A0A6P7DY72 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101113467 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6E2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RAB7A ^@ http://purl.uniprot.org/uniprot/A0A6P3CX02 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KEF53_p08 ^@ http://purl.uniprot.org/uniprot/A0A0E3M1Y2|||http://purl.uniprot.org/uniprot/O78752 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase A chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with DNAJC30; interaction is direct (By similarity).|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/9940:EMC8 ^@ http://purl.uniprot.org/uniprot/A0A6P3EKX9|||http://purl.uniprot.org/uniprot/W5PPA8 ^@ Caution|||Similarity ^@ Belongs to the EMC8/EMC9 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101109377 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBN5|||http://purl.uniprot.org/uniprot/A0A6P7EN58 ^@ Caution|||Similarity ^@ Belongs to the aldo/keto reductase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPL23A ^@ http://purl.uniprot.org/uniprot/A0A6P3CX48|||http://purl.uniprot.org/uniprot/D4P8H6 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL23 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CST3 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQW5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HTR1F ^@ http://purl.uniprot.org/uniprot/W5NT63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.|||Membrane http://togogenome.org/gene/9940:GNG4 ^@ http://purl.uniprot.org/uniprot/A0A6P3TEQ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9940:LOC101109343 ^@ http://purl.uniprot.org/uniprot/W5NQL8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9940:CFAP91 ^@ http://purl.uniprot.org/uniprot/W5QEV6 ^@ Similarity ^@ Belongs to the CFAP91 family. http://togogenome.org/gene/9940:LOC101119111 ^@ http://purl.uniprot.org/uniprot/A0A836AG40|||http://purl.uniprot.org/uniprot/W5QEB0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:CDPF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECL4 ^@ Caution|||Similarity ^@ Belongs to the CDPF1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AGTPBP1 ^@ http://purl.uniprot.org/uniprot/W5PGD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||cytosol http://togogenome.org/gene/9940:DRGX ^@ http://purl.uniprot.org/uniprot/W5NV96 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:PGLYRP4 ^@ http://purl.uniprot.org/uniprot/W5NQG3 ^@ Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. http://togogenome.org/gene/9940:MMP19 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7Y6|||http://purl.uniprot.org/uniprot/W5PMR2 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9940:CNOT11 ^@ http://purl.uniprot.org/uniprot/A0A836AGI7|||http://purl.uniprot.org/uniprot/W5PUR1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT11 family.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CEBPG ^@ http://purl.uniprot.org/uniprot/A0A6P7ERF9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FGF6 ^@ http://purl.uniprot.org/uniprot/W5PK90 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9940:SLTM ^@ http://purl.uniprot.org/uniprot/A0A6P3YK62 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AQP1 ^@ http://purl.uniprot.org/uniprot/P56401 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).|||Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Detected in fetal kidney (at protein level). Detected in fetal kidney.|||Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.|||Homotetramer (By similarity). Interacts with EPHB2; involved in endolymph production in the inner ear. Identified in a complex with STOM (By similarity).|||Pharmacologically inhibited by submillimolar concentrations of mercury. http://togogenome.org/gene/9940:LOC101102857 ^@ http://purl.uniprot.org/uniprot/A0A6P7EG13|||http://purl.uniprot.org/uniprot/W5PD15 ^@ Caution|||Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/9940:MED11 ^@ http://purl.uniprot.org/uniprot/A0A6P3ED31|||http://purl.uniprot.org/uniprot/W5PCX7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 11 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARL1 ^@ http://purl.uniprot.org/uniprot/B2LYL2 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9940:PPP1R12A ^@ http://purl.uniprot.org/uniprot/A0A6P3TL67 ^@ Caution|||Subcellular Location Annotation|||Subunit ^@ PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||stress fiber http://togogenome.org/gene/9940:LOC101109774 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHF8|||http://purl.uniprot.org/uniprot/W5P6Q9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KRTAP6-1 ^@ http://purl.uniprot.org/uniprot/A0A836AH50|||http://purl.uniprot.org/uniprot/Q02958|||http://purl.uniprot.org/uniprot/Q53YS7 ^@ Caution|||Developmental Stage|||Function|||Similarity|||Subunit ^@ Belongs to the KRTAP type 6 family.|||In the wool cortex, wool keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant wool shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of wool keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with wool keratins.|||The KAP6 proteins are first expressed in differentiating hair shaft keratinocytes, a considerable distance above the proliferative zone of the follicle bulb.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM255A ^@ http://purl.uniprot.org/uniprot/A0A6P3ESM9|||http://purl.uniprot.org/uniprot/W5PU27 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM255 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UGT8 ^@ http://purl.uniprot.org/uniprot/A0A836A6J5|||http://purl.uniprot.org/uniprot/W5Q9Z6 ^@ Caution|||Similarity ^@ Belongs to the UDP-glycosyltransferase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FABP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9X5|||http://purl.uniprot.org/uniprot/W5QHV3 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.|||Cytoplasm|||Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NOC3L ^@ http://purl.uniprot.org/uniprot/W5P1F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF/MAK21 family.|||nucleolus http://togogenome.org/gene/9940:BCL6B ^@ http://purl.uniprot.org/uniprot/A0A6P3E9Z6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E919|||http://purl.uniprot.org/uniprot/A0A6P3TN07 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the telombin family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||telomere http://togogenome.org/gene/9940:CTNNBL1 ^@ http://purl.uniprot.org/uniprot/W5Q9P0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:ARCN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EK90|||http://purl.uniprot.org/uniprot/W5PLQ6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC105605457 ^@ http://purl.uniprot.org/uniprot/A0A6P7EGT3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AJAP1 ^@ http://purl.uniprot.org/uniprot/W5PY23 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:SLC25A12 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8K2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC105615211 ^@ http://purl.uniprot.org/uniprot/A0A836AFR0 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:VEZT ^@ http://purl.uniprot.org/uniprot/W5Q3B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vezatin family.|||Cell membrane|||Membrane|||Nucleus|||adherens junction http://togogenome.org/gene/9940:ASIC1 ^@ http://purl.uniprot.org/uniprot/W5Q9I4|||http://purl.uniprot.org/uniprot/W5Q9I5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:TXLNG ^@ http://purl.uniprot.org/uniprot/A0A6P3EH23|||http://purl.uniprot.org/uniprot/W5PUJ8 ^@ Caution|||Similarity ^@ Belongs to the taxilin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC30A6 ^@ http://purl.uniprot.org/uniprot/W5PLW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9940:SLC8A3 ^@ http://purl.uniprot.org/uniprot/W5QJ75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:GFOD2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJI7|||http://purl.uniprot.org/uniprot/A0A6P7ER65 ^@ Caution|||Similarity ^@ Belongs to the Gfo/Idh/MocA family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101105276 ^@ http://purl.uniprot.org/uniprot/A0A6P3ELD4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC105613289 ^@ http://purl.uniprot.org/uniprot/A0A6P3YKP1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PGC ^@ http://purl.uniprot.org/uniprot/W5NX00 ^@ Function|||Similarity ^@ Belongs to the peptidase A1 family.|||Hydrolyzes a variety of proteins. http://togogenome.org/gene/9940:F9 ^@ http://purl.uniprot.org/uniprot/W5PLL2 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9940:LOC101110546 ^@ http://purl.uniprot.org/uniprot/A0A836A0U0|||http://purl.uniprot.org/uniprot/W5PMC5 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UBIAD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJN5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DAP3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E635 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS29 family.|||Mitochondrion|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RRAGA ^@ http://purl.uniprot.org/uniprot/A0A6P3CWW6|||http://purl.uniprot.org/uniprot/C5IJ87 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STT3A ^@ http://purl.uniprot.org/uniprot/A0A6P3ED77 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PSIP1 ^@ http://purl.uniprot.org/uniprot/B8Y8S3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HDGF family.|||Nucleus http://togogenome.org/gene/9940:ZBTB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TPE4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C17H12orf43 ^@ http://purl.uniprot.org/uniprot/A0A6P3EME4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CUSTOS family.|||Nucleus envelope|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KIF20A ^@ http://purl.uniprot.org/uniprot/A0A6P3E4S3|||http://purl.uniprot.org/uniprot/W5Q2V6 ^@ Caution|||Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CTSV ^@ http://purl.uniprot.org/uniprot/A0A6P3E0Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9940:AKT1 ^@ http://purl.uniprot.org/uniprot/C5IJA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.|||Cytoplasm http://togogenome.org/gene/9940:GTF2F2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9C0|||http://purl.uniprot.org/uniprot/W5PCK0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF beta subunit family.|||Nucleus|||TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZWILCH ^@ http://purl.uniprot.org/uniprot/A0A836A2M5|||http://purl.uniprot.org/uniprot/W5QA15 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZWILCH family.|||Component of the RZZ complex.|||Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||kinetochore http://togogenome.org/gene/9940:GJA9 ^@ http://purl.uniprot.org/uniprot/W5PIQ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9940:RGS2 ^@ http://purl.uniprot.org/uniprot/W5PIT6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||Membrane|||nucleolus http://togogenome.org/gene/9940:CT83 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENH7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLAT ^@ http://purl.uniprot.org/uniprot/W5NYU0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9940:ACLY ^@ http://purl.uniprot.org/uniprot/Q2TCH3 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated at Lys-540, Lys-546 and Lys-554 by KAT2B/PCAF (By similarity). Acetylation is promoted by glucose and stabilizes the protein, probably by preventing ubiquitination at the same sites (By similarity). Acetylation promotes de novo lipid synthesis (By similarity). Deacetylated by SIRT2 (By similarity).|||Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.|||Homotetramer.|||ISGylated.|||In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.|||In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.|||Phosphorylated by PKA and GSK3 in a sequential manner; phosphorylation results in activation of its activity (By similarity). Phosphorylation on Thr-447 and Ser-451 depends on the phosphorylation state of Ser-455 (By similarity). Phosphorylation on Ser-455 is decreased by prior phosphorylation on the other 2 residues (By similarity).|||Phosphorylation results in activation of its activity (By similarity). Glucose 6-phosphate, fructose 6-phosphate, fructose 2,6-bisphosphate, ribulose 5-phosphate, and fructose 1,6-bisphosphate also act as activators (By similarity).|||Ubiquitinated at Lys-540, Lys-546 and Lys-554 by the BCR(KLHL25) E3 ubiquitin ligase complex and UBR4, leading to its degradation (By similarity). Ubiquitination is probably inhibited by acetylation at same site (By similarity). BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells (By similarity).|||cytosol http://togogenome.org/gene/9940:TNFRSF9 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE71|||http://purl.uniprot.org/uniprot/W5PKG1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRE11 ^@ http://purl.uniprot.org/uniprot/W5NVN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MRE11/RAD32 family.|||Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.|||Nucleus http://togogenome.org/gene/9940:IL26 ^@ http://purl.uniprot.org/uniprot/W5NUV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9940:NARF ^@ http://purl.uniprot.org/uniprot/W5Q4R4 ^@ Similarity ^@ Belongs to the NARF family. http://togogenome.org/gene/9940:SLC6A7 ^@ http://purl.uniprot.org/uniprot/W5P9Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9940:LOC101108252 ^@ http://purl.uniprot.org/uniprot/W5PC84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:CD59 ^@ http://purl.uniprot.org/uniprot/A0A6P3YM37 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SIN3A ^@ http://purl.uniprot.org/uniprot/A0A6P3YRY4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:SF3B4 ^@ http://purl.uniprot.org/uniprot/A0A6P3DYX0|||http://purl.uniprot.org/uniprot/W5QHR6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B4 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CHMP4C ^@ http://purl.uniprot.org/uniprot/A0A836ABB3|||http://purl.uniprot.org/uniprot/W5PZJ0 ^@ Caution|||Similarity ^@ Belongs to the SNF7 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ITIH3 ^@ http://purl.uniprot.org/uniprot/W5NSH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9940:RHEB ^@ http://purl.uniprot.org/uniprot/A0A6P9FQL5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101109269 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4Q1 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TOB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TWX7|||http://purl.uniprot.org/uniprot/A0A6P3YL74 ^@ Caution|||Similarity ^@ Belongs to the BTG family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SMPD1 ^@ http://purl.uniprot.org/uniprot/C8BKD7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) ions per subunit.|||Converts sphingomyelin to ceramide.|||Secreted http://togogenome.org/gene/9940:LOC101110545 ^@ http://purl.uniprot.org/uniprot/W5PE14 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9940:ZFX ^@ http://purl.uniprot.org/uniprot/A0A6P3TFE5|||http://purl.uniprot.org/uniprot/A0A6P3YTP4 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRPL53 ^@ http://purl.uniprot.org/uniprot/W5PT24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL53 family.|||Mitochondrion http://togogenome.org/gene/9940:SPSB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EI35 ^@ Similarity ^@ Belongs to the SPSB family. http://togogenome.org/gene/9940:LOC101107284 ^@ http://purl.uniprot.org/uniprot/W5PRN7 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:PLA2G5 ^@ http://purl.uniprot.org/uniprot/A0A836AC67|||http://purl.uniprot.org/uniprot/W5NS89 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCNDBP1 ^@ http://purl.uniprot.org/uniprot/W5QHC4 ^@ Similarity|||Subunit ^@ Belongs to the CCNDBP1 family.|||Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3. http://togogenome.org/gene/9940:SQLE ^@ http://purl.uniprot.org/uniprot/A0A6P3CWQ1|||http://purl.uniprot.org/uniprot/A6YQW0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GGTA1 ^@ http://purl.uniprot.org/uniprot/Q6SVU1|||http://purl.uniprot.org/uniprot/W5PYG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 6 family.|||Membrane http://togogenome.org/gene/9940:IFNE ^@ http://purl.uniprot.org/uniprot/A0A6P3TM81|||http://purl.uniprot.org/uniprot/W5PGC3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MPPED2 ^@ http://purl.uniprot.org/uniprot/A0A6P7EW68 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/9940:LTA4H ^@ http://purl.uniprot.org/uniprot/A0A6P3EAV9 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LPXN ^@ http://purl.uniprot.org/uniprot/W5PN77 ^@ Similarity ^@ Belongs to the paxillin family. http://togogenome.org/gene/9940:B4GALT3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E689 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPL6 ^@ http://purl.uniprot.org/uniprot/W5P3J0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/9940:GGNBP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TR97 ^@ Caution|||Function ^@ May be involved in spermatogenesis.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SPINK7 ^@ http://purl.uniprot.org/uniprot/A0A836D386 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MOB1B ^@ http://purl.uniprot.org/uniprot/A0A6P3YM01 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GHSR ^@ http://purl.uniprot.org/uniprot/A0A6P7DX51|||http://purl.uniprot.org/uniprot/Q8MHZ5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PMP22 ^@ http://purl.uniprot.org/uniprot/A0A6P3THK8|||http://purl.uniprot.org/uniprot/C5IS97 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Might be involved in growth regulation, and in myelinization in the peripheral nervous system.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KLHL6 ^@ http://purl.uniprot.org/uniprot/A0A6P3E839 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GATA3 ^@ http://purl.uniprot.org/uniprot/F8WQV3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:BCAP29 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8U8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||Membrane|||Plays a role in the export of secreted proteins in the ER.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PDCD10 ^@ http://purl.uniprot.org/uniprot/A0A6P3TMA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDCD10 family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9940:RAG1 ^@ http://purl.uniprot.org/uniprot/W5PL78 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RAG1 family.|||Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).|||Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.|||Homodimer.|||Nucleus|||The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp. http://togogenome.org/gene/9940:LHFPL6 ^@ http://purl.uniprot.org/uniprot/A0A6P3YJL5 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CHFR ^@ http://purl.uniprot.org/uniprot/W5PHM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CHFR family.|||PML body http://togogenome.org/gene/9940:LCAT ^@ http://purl.uniprot.org/uniprot/C5IS96 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9940:TNP1 ^@ http://purl.uniprot.org/uniprot/A0A836AE57|||http://purl.uniprot.org/uniprot/P22613 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the nuclear transition protein 1 family.|||Chromosome|||Nucleus|||Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.|||Testis.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C23H18orf21 ^@ http://purl.uniprot.org/uniprot/A0A6P3YPS3 ^@ Caution|||Similarity ^@ Belongs to the UPF0711 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ENPP4 ^@ http://purl.uniprot.org/uniprot/A0A6P7D8A5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||Cell membrane|||Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.|||Membrane http://togogenome.org/gene/9940:ANTKMT ^@ http://purl.uniprot.org/uniprot/A0A6P3EQL7|||http://purl.uniprot.org/uniprot/W5PVW4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANT/ATPSC lysine N-methyltransferase family.|||Mitochondrion membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RNF7 ^@ http://purl.uniprot.org/uniprot/A0A6P3E0G9|||http://purl.uniprot.org/uniprot/W5P9B7 ^@ Caution|||Similarity ^@ Belongs to the RING-box family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDC42SE2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YHY6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.|||Membrane|||Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.|||cytoskeleton http://togogenome.org/gene/9940:ZFAND2B ^@ http://purl.uniprot.org/uniprot/A0A6P3E1R6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RAD54L2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC99|||http://purl.uniprot.org/uniprot/W5PBH6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101117955 ^@ http://purl.uniprot.org/uniprot/P68302 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.|||Interacts with EOLA1.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. http://togogenome.org/gene/9940:DUOXA1 ^@ http://purl.uniprot.org/uniprot/W5QIS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DUOXA family.|||Membrane http://togogenome.org/gene/9940:BMPR2 ^@ http://purl.uniprot.org/uniprot/V9HXG2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. http://togogenome.org/gene/9940:LOC101102391 ^@ http://purl.uniprot.org/uniprot/W5PSV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:MYOG ^@ http://purl.uniprot.org/uniprot/D3YKV7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:DLD ^@ http://purl.uniprot.org/uniprot/A0A6P3EBV7|||http://purl.uniprot.org/uniprot/W5PB39 ^@ Caution|||Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||acrosome|||flagellum http://togogenome.org/gene/9940:PDGFB ^@ http://purl.uniprot.org/uniprot/Q95229 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Antiparallel homodimer; disulfide-linked. Antiparallel heterodimer with PDGFA; disulfide-linked. The PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with XLKD1 (By similarity). Interacts with LRP1 (By similarity). Interacts with SORL1 (via the N-terminal ectodomain) (By similarity).|||Belongs to the PDGF/VEGF growth factor family.|||Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).|||Secreted http://togogenome.org/gene/9940:SCGB2A2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQJ2 ^@ Caution|||Subcellular Location Annotation ^@ Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HCST ^@ http://purl.uniprot.org/uniprot/A0A6P3TUD9|||http://purl.uniprot.org/uniprot/A0A6P3TVN0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAP10 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IRF6 ^@ http://purl.uniprot.org/uniprot/Q9N136|||http://purl.uniprot.org/uniprot/W5PT47 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9940:LOC101121387 ^@ http://purl.uniprot.org/uniprot/A0A836ADP7 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LIAS ^@ http://purl.uniprot.org/uniprot/A0A6P3E5F3|||http://purl.uniprot.org/uniprot/W5PQ59 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Mitochondrion|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ANKFY1 ^@ http://purl.uniprot.org/uniprot/A0A836CY98 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KRT17 ^@ http://purl.uniprot.org/uniprot/U3MXA9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9940:SMAD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHN1|||http://purl.uniprot.org/uniprot/A0A835ZPQ5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101107266 ^@ http://purl.uniprot.org/uniprot/A0A6P3E775|||http://purl.uniprot.org/uniprot/W5QHN1 ^@ Caution|||Similarity ^@ Belongs to the SNF7 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC18B1 ^@ http://purl.uniprot.org/uniprot/W5PYN2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:DBX2 ^@ http://purl.uniprot.org/uniprot/W5QEA0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:PRPF38A ^@ http://purl.uniprot.org/uniprot/A0A6P3DY98|||http://purl.uniprot.org/uniprot/W5P5R7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRP38 family.|||Component of the spliceosome B complex.|||Involved in pre-mRNA splicing as a component of the spliceosome.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:F11R ^@ http://purl.uniprot.org/uniprot/A0A6P3E4M9|||http://purl.uniprot.org/uniprot/W5PHN9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||tight junction http://togogenome.org/gene/9940:ALDH2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHX6|||http://purl.uniprot.org/uniprot/W5PLV2 ^@ Caution|||Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCDC89 ^@ http://purl.uniprot.org/uniprot/A0A6P3TCP0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FOXP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3T779 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:MAPK14 ^@ http://purl.uniprot.org/uniprot/A0A6P3CX87|||http://purl.uniprot.org/uniprot/B7TJ15 ^@ Caution|||Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STAT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3CX40|||http://purl.uniprot.org/uniprot/C8BKE1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DCBLD2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E032|||http://purl.uniprot.org/uniprot/W5Q8T4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UGT1A1 ^@ http://purl.uniprot.org/uniprot/F1CGV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9940:TSR2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EMV3|||http://purl.uniprot.org/uniprot/W5P914 ^@ Caution|||Function|||Similarity ^@ Belongs to the TSR2 family.|||May be involved in 20S pre-rRNA processing.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CD247 ^@ http://purl.uniprot.org/uniprot/P29329 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CD3Z/FCER1G family.|||Cell membrane|||Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN).|||Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.|||The ITAM domains mediate interaction with SHB.|||The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. Interacts with SLA. Interacts with TRAT1. Interacts with DOCK2. Interacts with SLA2. Interacts with SHB. Interacts with ZAP70. Interacts (tyrosine phosphorylated) with SHC1 (via SH2 domain). Interacts with PTPRC. Interacts with CRK; this interaction regulates CD3Z phosphorylation. Interacts (on T cell side) with CD81, ICAM1 and CD9 at immunological synapses between antigen-presenting cells and T cells. Interacts with CD160. Interacts with LY6E. Interacts with LY6E (By similarity). The signaling subunit of immunoglobulin gamma (IgG) Fc receptor complex. As a homodimer or a heterodimer with FCER1G, associates with the ligand binding subunit FCGR3A (via transmembrane domain); this interaction is a prerequisite for Fc receptor complex expression on the cell surface. http://togogenome.org/gene/9940:IDO2 ^@ http://purl.uniprot.org/uniprot/W5NW87 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/9940:NECAP1 ^@ http://purl.uniprot.org/uniprot/A0A836A927|||http://purl.uniprot.org/uniprot/W5NWV3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9940:SPRING1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EMA6|||http://purl.uniprot.org/uniprot/W5P6F6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPRING family.|||Golgi apparatus membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BROX ^@ http://purl.uniprot.org/uniprot/A0A6P3TIN4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BROX family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NTAN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ELI4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CPA3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E753 ^@ Caution|||Similarity ^@ Belongs to the peptidase M14 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UBAP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5R5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SOWAHC ^@ http://purl.uniprot.org/uniprot/A0A6P3TKR3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:P4HA1 ^@ http://purl.uniprot.org/uniprot/W5PBR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9940:ENKUR ^@ http://purl.uniprot.org/uniprot/W5P037 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9940:ZPBP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TI69|||http://purl.uniprot.org/uniprot/W5PRG3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the zona pellucida-binding protein Sp38 family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LAMTOR4 ^@ http://purl.uniprot.org/uniprot/A0A6P3ER19 ^@ Caution|||Similarity ^@ Belongs to the LAMTOR4 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SRP19 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEF6|||http://purl.uniprot.org/uniprot/W5Q3G3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP19 family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC44A5 ^@ http://purl.uniprot.org/uniprot/W5PST6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/9940:LOC101116648 ^@ http://purl.uniprot.org/uniprot/W5NT60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:TNP2 ^@ http://purl.uniprot.org/uniprot/W5P9A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear transition protein 2 family.|||Nucleus|||Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. http://togogenome.org/gene/9940:LOC101102729 ^@ http://purl.uniprot.org/uniprot/W5Q9C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Membrane http://togogenome.org/gene/9940:LOC101110966 ^@ http://purl.uniprot.org/uniprot/W5PV97 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:LOC101103561 ^@ http://purl.uniprot.org/uniprot/W5NT71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:LOC105614315 ^@ http://purl.uniprot.org/uniprot/A0A6P3YLY0|||http://purl.uniprot.org/uniprot/W5PRJ6 ^@ Caution|||Similarity ^@ Belongs to the aldo/keto reductase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NDUFB2 ^@ http://purl.uniprot.org/uniprot/A0A8N7XJB4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CFI ^@ http://purl.uniprot.org/uniprot/A0A6P3EA58|||http://purl.uniprot.org/uniprot/W5P5I3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPL19 ^@ http://purl.uniprot.org/uniprot/A0A6P3EIR5 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Component of the large ribosomal subunit.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRAF6 ^@ http://purl.uniprot.org/uniprot/A0A6P3YR70|||http://purl.uniprot.org/uniprot/W5QCP4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family. A subfamily.|||Lipid droplet|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cell cortex http://togogenome.org/gene/9940:DNAH7 ^@ http://purl.uniprot.org/uniprot/W5PYR8 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/9940:BTK ^@ http://purl.uniprot.org/uniprot/A0A835ZLT1|||http://purl.uniprot.org/uniprot/W5NU60 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STAT5A ^@ http://purl.uniprot.org/uniprot/P42231 ^@ Function|||Induction|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the transcription factor STAT family.|||By prolactin.|||Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.|||Cytoplasm|||Forms a homodimer or a heterodimer with a related family member. Binds NR3C1. Interacts with NCOA1 and SOCS7. Interacts with ERBB4 (By similarity). Interacts with EBF4.|||Found in mammary gland and, in lesser extent, in ovary, thymus, spleen, kidney, lung, muscle and adrenal gland.|||ISGylated.|||Nucleus|||Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO (By similarity). Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus (By similarity). Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity). Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2 at Tyr-694 (By similarity). http://togogenome.org/gene/9940:PRPS1L1 ^@ http://purl.uniprot.org/uniprot/A0A836A7D5|||http://purl.uniprot.org/uniprot/W5PE70 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EAF2 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZM8|||http://purl.uniprot.org/uniprot/W5QFR2 ^@ Caution|||Similarity ^@ Belongs to the EAF family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MORN4 ^@ http://purl.uniprot.org/uniprot/A0A6P3T4T7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OS9 ^@ http://purl.uniprot.org/uniprot/W5P6E0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum lumen http://togogenome.org/gene/9940:DAD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAU1|||http://purl.uniprot.org/uniprot/W5QDT3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ACKR3 ^@ http://purl.uniprot.org/uniprot/W5NQ57 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9940:RMI1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TBR7|||http://purl.uniprot.org/uniprot/A0A6P3YFS0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RMI1 family.|||Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HSPA13 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4S1|||http://purl.uniprot.org/uniprot/W5Q411 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Binds UBQLN2.|||Endoplasmic reticulum|||Has peptide-independent ATPase activity.|||Microsome|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TOP2A ^@ http://purl.uniprot.org/uniprot/A0A6P3TX24 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase family.|||Homodimer.|||Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9940:AKIRIN2 ^@ http://purl.uniprot.org/uniprot/A0A6P3CXD7|||http://purl.uniprot.org/uniprot/G3LHX2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LRP6 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECC1|||http://purl.uniprot.org/uniprot/W5QI85 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDLR family.|||Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.|||Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SMAD2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YNX4|||http://purl.uniprot.org/uniprot/A0A6P7DD43 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101120200 ^@ http://purl.uniprot.org/uniprot/A0A835ZVV9|||http://purl.uniprot.org/uniprot/W5QFN5 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BAC5 ^@ http://purl.uniprot.org/uniprot/P79362 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ BAC5 sequence consists almost exclusively of X-P-P-Y repeats.|||Belongs to the cathelicidin family.|||Binds to the lipid A moiety of bacterial lipipolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Potent antimicrobial activity (By similarity).|||Elastase is responsible for its maturation.|||Secreted http://togogenome.org/gene/9940:ATG5 ^@ http://purl.uniprot.org/uniprot/A0A6P3TGE0|||http://purl.uniprot.org/uniprot/A0A6P3TPV8|||http://purl.uniprot.org/uniprot/W5PNH4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Conjugated with ATG12.|||Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.|||May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.|||Preautophagosomal structure membrane http://togogenome.org/gene/9940:MT3 ^@ http://purl.uniprot.org/uniprot/Q8MKE4 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium (By similarity). http://togogenome.org/gene/9940:LOC101121681 ^@ http://purl.uniprot.org/uniprot/A0A836AHE5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STIP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDB9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLF2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDM7|||http://purl.uniprot.org/uniprot/W5Q2L7 ^@ Caution|||Similarity ^@ Belongs to the FAM178 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KEF53_p07 ^@ http://purl.uniprot.org/uniprot/H1ZZ70|||http://purl.uniprot.org/uniprot/O21619 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome (By similarity). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:27654913).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9940:ZBTB25 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFB8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TBX21 ^@ http://purl.uniprot.org/uniprot/W5PES9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9940:SCGB1A1 ^@ http://purl.uniprot.org/uniprot/D6C4M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the secretoglobin family.|||Secreted http://togogenome.org/gene/9940:MLF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TC46|||http://purl.uniprot.org/uniprot/W5NWV2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MLF family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101108428 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC83 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NUDT16 ^@ http://purl.uniprot.org/uniprot/Q2V8X7 ^@ Cofactor|||Developmental Stage|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. NUDT16 subfamily.|||Binds 3 or 4 divalent metal cations. Acts specifically on U8 snoRNA with magnesium as cofactor. Has broad substrate specificity with bound manganese or cobalt (in vitro).|||By steroid hormones.|||Cytoplasm|||Homodimer.|||NUDT16 mRNA concentrations are elevated 10-fold in the endometrium of sheep from day 5 to 9 of the estrous cycle and return to basal levels by day 11.|||Nucleus|||RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms. The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP. Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions (By similarity). Exhibits decapping activity towards NAD-capped RNAs and FAD-capped RNAs (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity).|||nucleolus|||nucleoplasm http://togogenome.org/gene/9940:SLC1A1 ^@ http://purl.uniprot.org/uniprot/W5PV81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9940:PIGN ^@ http://purl.uniprot.org/uniprot/A0A6P3TE49 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.|||Endoplasmic reticulum membrane|||Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.|||Membrane http://togogenome.org/gene/9940:ORMDL2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAU4|||http://purl.uniprot.org/uniprot/A0A6P3TK34 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CPT2 ^@ http://purl.uniprot.org/uniprot/W5P878 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9940:CNOT8 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9S3|||http://purl.uniprot.org/uniprot/A0A6P3TH76 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AK2 ^@ http://purl.uniprot.org/uniprot/W5QI77 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK2 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion intermembrane space|||Monomer. http://togogenome.org/gene/9940:LOC101102512 ^@ http://purl.uniprot.org/uniprot/A0A6P3EKY5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SDC2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YNA7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IDO1 ^@ http://purl.uniprot.org/uniprot/A0A6P3CX74|||http://purl.uniprot.org/uniprot/B6VEZ9 ^@ Caution|||Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OXSR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEF0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101106638 ^@ http://purl.uniprot.org/uniprot/A0A6P3TIN9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:COMMD5 ^@ http://purl.uniprot.org/uniprot/A0A6P3YN49 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HNRNPUL2 ^@ http://purl.uniprot.org/uniprot/W5Q5S5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:ABHD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAS2 ^@ Caution|||Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LMBRD2 ^@ http://purl.uniprot.org/uniprot/A0A835ZYJ3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TNFRSF1B ^@ http://purl.uniprot.org/uniprot/W5Q6X2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:IFT46 ^@ http://purl.uniprot.org/uniprot/W5PL42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT46 family.|||cilium|||cilium basal body http://togogenome.org/gene/9940:TFCP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TJM4|||http://purl.uniprot.org/uniprot/W5Q7H8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STEAP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC00 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:ATL3 ^@ http://purl.uniprot.org/uniprot/A0A835ZM39|||http://purl.uniprot.org/uniprot/W5NY07 ^@ Caution|||Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POU5F1 ^@ http://purl.uniprot.org/uniprot/W5PJV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-5 subfamily.|||Nucleus http://togogenome.org/gene/9940:SGF29 ^@ http://purl.uniprot.org/uniprot/A0A6P3TJP9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:PPP1R2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7Z8|||http://purl.uniprot.org/uniprot/W5QGP7 ^@ Caution|||Similarity ^@ Belongs to the protein phosphatase inhibitor 2 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RNF146 ^@ http://purl.uniprot.org/uniprot/W5PCV4 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.|||The WWE domain mediates non-covalent poly(ADP-ribose)-binding.|||Ubiquitinated; autoubiquitinated.|||cytosol http://togogenome.org/gene/9940:CENPM ^@ http://purl.uniprot.org/uniprot/A0A6P3E8F8|||http://purl.uniprot.org/uniprot/W5QBT9 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C1QTNF3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDR1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SQSTM1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQM3|||http://purl.uniprot.org/uniprot/C5ISA9 ^@ Caution|||Subcellular Location Annotation ^@ Lysosome|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||autophagosome http://togogenome.org/gene/9940:ARL8B ^@ http://purl.uniprot.org/uniprot/C5IWT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Synapse|||spindle http://togogenome.org/gene/9940:FTO ^@ http://purl.uniprot.org/uniprot/A7UHZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fto family.|||Cytoplasm|||Nucleus speckle http://togogenome.org/gene/9940:PFDN5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7L1|||http://purl.uniprot.org/uniprot/W5Q4Z0 ^@ Caution|||Similarity ^@ Belongs to the prefoldin subunit alpha family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AGFG2 ^@ http://purl.uniprot.org/uniprot/A0A6P3ER09 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ME1 ^@ http://purl.uniprot.org/uniprot/B5SZL5 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/9940:SEC23B ^@ http://purl.uniprot.org/uniprot/A0A6P3YLV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9940:GEMIN5 ^@ http://purl.uniprot.org/uniprot/A0A836A6Y4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101104594 ^@ http://purl.uniprot.org/uniprot/A0A836CWF6|||http://purl.uniprot.org/uniprot/W5P935 ^@ Caution|||Similarity ^@ Belongs to the strictosidine synthase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TGDS ^@ http://purl.uniprot.org/uniprot/A0A6P3YNC4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARFGEF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHG1|||http://purl.uniprot.org/uniprot/W5NSV2 ^@ Caution|||Subcellular Location Annotation ^@ Golgi apparatus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||perinuclear region http://togogenome.org/gene/9940:MTPN ^@ http://purl.uniprot.org/uniprot/A0A6P3E495 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PGM2L1 ^@ http://purl.uniprot.org/uniprot/W5PJJ5 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9940:LOC101102756 ^@ http://purl.uniprot.org/uniprot/W5PRJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:MAGEF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E822 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZNF174 ^@ http://purl.uniprot.org/uniprot/A0A6P3ELG1|||http://purl.uniprot.org/uniprot/A0A6P3T9M4 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PNPO ^@ http://purl.uniprot.org/uniprot/W5PCU5 ^@ Function|||Similarity ^@ Belongs to the pyridoxamine 5'-phosphate oxidase family.|||Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). http://togogenome.org/gene/9940:DUSP6 ^@ http://purl.uniprot.org/uniprot/W5Q228 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9940:DNAAF4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EG33|||http://purl.uniprot.org/uniprot/A0A6P7E942 ^@ Caution|||Subcellular Location Annotation ^@ Dynein axonemal particle|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||neuron projection http://togogenome.org/gene/9940:ANAPC16 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEH9|||http://purl.uniprot.org/uniprot/A0A6P3ES15 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC16 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||kinetochore http://togogenome.org/gene/9940:LOC101102541 ^@ http://purl.uniprot.org/uniprot/W5P3J0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/9940:LOC101106046 ^@ http://purl.uniprot.org/uniprot/W5NRP7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9940:CD5 ^@ http://purl.uniprot.org/uniprot/A0A6P3TF51|||http://purl.uniprot.org/uniprot/W5Q3P2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UCP3 ^@ http://purl.uniprot.org/uniprot/R4TWY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9940:RPL9 ^@ http://purl.uniprot.org/uniprot/A0A6P3EA32|||http://purl.uniprot.org/uniprot/W5NTE7 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL6 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CEBPA ^@ http://purl.uniprot.org/uniprot/W5VSV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/9940:ZNF706 ^@ http://purl.uniprot.org/uniprot/W5QB53 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9940:ALG8 ^@ http://purl.uniprot.org/uniprot/W5P9G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9940:LOC101123333 ^@ http://purl.uniprot.org/uniprot/A0A836CVM4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AASDH ^@ http://purl.uniprot.org/uniprot/W5P092 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9940:DYNLT3 ^@ http://purl.uniprot.org/uniprot/Q6XXL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).|||Belongs to the dynein light chain Tctex-type family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2. Interacts with BUB3. Interacts with SATB1 in nucleus to form complex with matrix attachment regions (MARs) of DNA (By similarity).|||Nucleus|||cytoskeleton|||kinetochore http://togogenome.org/gene/9940:SNRPA1 ^@ http://purl.uniprot.org/uniprot/B2LU27 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/9940:KRTAP4.3 ^@ http://purl.uniprot.org/uniprot/A8WEL6 ^@ Function ^@ The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa). http://togogenome.org/gene/9940:EXOSC7 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEN9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MMP7 ^@ http://purl.uniprot.org/uniprot/B6UV58 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Binds 2 calcium ions per subunit. http://togogenome.org/gene/9940:MELK ^@ http://purl.uniprot.org/uniprot/W5PPJ8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/9940:GPT2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFB3|||http://purl.uniprot.org/uniprot/W5Q2J9 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.|||Homodimer.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ANXA1 ^@ http://purl.uniprot.org/uniprot/W5PSZ5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the annexin family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Nucleus|||The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.|||cilium|||extracellular exosome|||extracellular space|||phagocytic cup|||secretory vesicle lumen http://togogenome.org/gene/9940:STX8 ^@ http://purl.uniprot.org/uniprot/A0A6P3YNV6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:QPCT ^@ http://purl.uniprot.org/uniprot/C8BKD8 ^@ Similarity ^@ Belongs to the glutaminyl-peptide cyclotransferase family. http://togogenome.org/gene/9940:PWWP3A ^@ http://purl.uniprot.org/uniprot/W5PPK7 ^@ Similarity ^@ Belongs to the PWWP3A family. http://togogenome.org/gene/9940:SELL ^@ http://purl.uniprot.org/uniprot/W5PMK6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the selectin/LECAM family.|||Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.|||Cell membrane|||Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9940:SAE1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFT0|||http://purl.uniprot.org/uniprot/W5PMQ9 ^@ Caution|||Similarity ^@ Belongs to the ubiquitin-activating E1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZPR1 ^@ http://purl.uniprot.org/uniprot/A0A835ZRY6 ^@ Caution|||Similarity ^@ Belongs to the ZPR1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101123466 ^@ http://purl.uniprot.org/uniprot/A0A6P3YJD1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RERGL ^@ http://purl.uniprot.org/uniprot/A0A6P3E3D0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MC5R ^@ http://purl.uniprot.org/uniprot/A0A6P3CWQ3|||http://purl.uniprot.org/uniprot/Q19BK7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GANAB ^@ http://purl.uniprot.org/uniprot/W5Q302 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/9940:COMMD3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EIJ1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101117015 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECH0|||http://purl.uniprot.org/uniprot/W5PA59 ^@ Caution|||Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATG13 ^@ http://purl.uniprot.org/uniprot/A0A6P3ED78|||http://purl.uniprot.org/uniprot/W5P0V9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.|||Belongs to the ATG13 family. Metazoan subfamily.|||Preautophagosomal structure|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101118932 ^@ http://purl.uniprot.org/uniprot/W5QHC6 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/9940:TPST1 ^@ http://purl.uniprot.org/uniprot/W5PL91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein sulfotransferase family.|||Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.|||Golgi apparatus membrane http://togogenome.org/gene/9940:INTS7 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEF1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 7 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARF1 ^@ http://purl.uniprot.org/uniprot/A0A6P7E1T3|||http://purl.uniprot.org/uniprot/C5IWU0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HOXB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EIP1|||http://purl.uniprot.org/uniprot/W5PB43 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLIN2 ^@ http://purl.uniprot.org/uniprot/A6ZE99 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9940:URI1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9P7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101114790 ^@ http://purl.uniprot.org/uniprot/A0A836D206 ^@ Caution|||Similarity ^@ Belongs to the intercrine beta (chemokine CC) family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJ98|||http://purl.uniprot.org/uniprot/W5PHD5 ^@ Caution|||Similarity ^@ Belongs to the intercrine beta (chemokine CC) family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GLYATL2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGV7|||http://purl.uniprot.org/uniprot/W5PPP8 ^@ Caution|||Similarity ^@ Belongs to the glycine N-acyltransferase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101113267 ^@ http://purl.uniprot.org/uniprot/A0A6P3EG12 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CD82 ^@ http://purl.uniprot.org/uniprot/W5NUN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9940:LOC101110319 ^@ http://purl.uniprot.org/uniprot/A0A836AKB9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GABRA1 ^@ http://purl.uniprot.org/uniprot/W5PWY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9940:APLP2 ^@ http://purl.uniprot.org/uniprot/W5PZB0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9940:LOC101117272 ^@ http://purl.uniprot.org/uniprot/W5NYL6 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9940:SLC25A5 ^@ http://purl.uniprot.org/uniprot/A0A836CSN2|||http://purl.uniprot.org/uniprot/B2MVW9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IL12RB2 ^@ http://purl.uniprot.org/uniprot/G1JRQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9940:DHRS9 ^@ http://purl.uniprot.org/uniprot/A0A6P3E1C5 ^@ Caution|||Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NPY4R2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TAB6|||http://purl.uniprot.org/uniprot/W5P0I3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CPEB4 ^@ http://purl.uniprot.org/uniprot/W5P288 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9940:CWC15 ^@ http://purl.uniprot.org/uniprot/A0A6P3TBG1 ^@ Similarity ^@ Belongs to the CWC15 family. http://togogenome.org/gene/9940:PAQR6 ^@ http://purl.uniprot.org/uniprot/W5P6Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9940:SLC25A3 ^@ http://purl.uniprot.org/uniprot/A0A6P3CXB5|||http://purl.uniprot.org/uniprot/B7U168 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Interacts with PPIF; the interaction is impaired by CsA.|||Membrane|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FIP1L1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YM81 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101105036 ^@ http://purl.uniprot.org/uniprot/W5QFN5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9940:YPEL1 ^@ http://purl.uniprot.org/uniprot/A0A6P7D2H6 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9940:ST7 ^@ http://purl.uniprot.org/uniprot/Q09YI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/9940:RHBDD2 ^@ http://purl.uniprot.org/uniprot/A0A6P3ELU6 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EFHB ^@ http://purl.uniprot.org/uniprot/W5Q2A6 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9940:ZNF22 ^@ http://purl.uniprot.org/uniprot/A0A6P3TK99 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM199 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGY6|||http://purl.uniprot.org/uniprot/W5Q920 ^@ Caution|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101103222 ^@ http://purl.uniprot.org/uniprot/W5QGU1 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 22 family.|||Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. http://togogenome.org/gene/9940:PCYOX1 ^@ http://purl.uniprot.org/uniprot/A0A836D3H7 ^@ Caution|||Similarity ^@ Belongs to the prenylcysteine oxidase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRM1 ^@ http://purl.uniprot.org/uniprot/A0A6P3CX03|||http://purl.uniprot.org/uniprot/C5IFA1|||http://purl.uniprot.org/uniprot/P68038 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the protamine P1 family.|||Chromosome|||Cross-linked by interchain disulfide bonds around the DNA-helix.|||Nucleus|||Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.|||Testis.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CSTA ^@ http://purl.uniprot.org/uniprot/W5QFV6 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/9940:HOGA1 ^@ http://purl.uniprot.org/uniprot/W5PMQ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the final step in the metabolic pathway of hydroxyproline.|||Homotetramer. http://togogenome.org/gene/9940:BEST3 ^@ http://purl.uniprot.org/uniprot/W5QGD5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bestrophin family.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9940:SMIM29 ^@ http://purl.uniprot.org/uniprot/A0A6P3EIZ8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KCNS3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TIQ7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9940:GLUD1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FRG8 ^@ Caution|||Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RIC8B ^@ http://purl.uniprot.org/uniprot/A0A6P3EB05|||http://purl.uniprot.org/uniprot/W5Q8I2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HERC3 ^@ http://purl.uniprot.org/uniprot/A0A836D246 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZNF629 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQW5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101117077 ^@ http://purl.uniprot.org/uniprot/W5PQF2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:CD40LG ^@ http://purl.uniprot.org/uniprot/Q4TVR2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.|||Belongs to the tumor necrosis factor family.|||Cell surface|||Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.|||Homotrimer. http://togogenome.org/gene/9940:CACNB1 ^@ http://purl.uniprot.org/uniprot/W5PLJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||Membrane|||sarcolemma http://togogenome.org/gene/9940:RBBP9 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEQ6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DNAJA4 ^@ http://purl.uniprot.org/uniprot/A0A836A0U4 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BICC1 ^@ http://purl.uniprot.org/uniprot/W5P1S7 ^@ Similarity ^@ Belongs to the BicC family. http://togogenome.org/gene/9940:MEF2A ^@ http://purl.uniprot.org/uniprot/A0A6P3TD82 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:PIN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDK0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MCTS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ESN3|||http://purl.uniprot.org/uniprot/W5PV64 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCTS1 family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MFAP5 ^@ http://purl.uniprot.org/uniprot/A0A6P3YL42|||http://purl.uniprot.org/uniprot/W5NV70 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||extracellular matrix http://togogenome.org/gene/9940:LOC101114075 ^@ http://purl.uniprot.org/uniprot/A0A6P3ELP7|||http://purl.uniprot.org/uniprot/A0A6P3T5T9 ^@ Caution|||Similarity ^@ Belongs to the sulfotransferase 1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PDS5A ^@ http://purl.uniprot.org/uniprot/A0A6P3YIC7|||http://purl.uniprot.org/uniprot/W5PRM6 ^@ Caution|||Similarity ^@ Belongs to the PDS5 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SUB1 ^@ http://purl.uniprot.org/uniprot/A0A6P7DQI1|||http://purl.uniprot.org/uniprot/W5PRF0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional coactivator PC4 family.|||General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).|||Homodimer. Interacts with CSTF2.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CHODL ^@ http://purl.uniprot.org/uniprot/A0A6P3E005 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SSTR5 ^@ http://purl.uniprot.org/uniprot/Q8MI04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:C5H19orf25 ^@ http://purl.uniprot.org/uniprot/W5PQU3 ^@ Similarity ^@ Belongs to the UPF0449 family. http://togogenome.org/gene/9940:HSD11B2 ^@ http://purl.uniprot.org/uniprot/P50168 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as cortisol, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as cortisone, in the presence of NAD(+) (PubMed:7929304, PubMed:7588402). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids (PubMed:7929304, PubMed:7588402). Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure (By similarity). Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen.Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone. Converts 7-beta-25-dihydroxycholesterol to 7-oxo-25-hydroxycholesterol in vitro. 7-beta-25-dihydroxycholesterol (not 7-oxo-25-hydroxycholesterol) acts as ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (By similarity). May protect ovulating oocytes and fertilizing spermatozoa from the adverse effects of cortisol (By similarity).|||Endoplasmic reticulum|||Highly expressed in the kidney and adrenal and at lower levels in the colon.|||Inhibited by glycyrrhetinic acid, carbenoloxone, 11-alpha-OH-progesterone and 11-beta-OH-progesterone.|||Interacts with ligand-free cytoplasmic NR3C2.|||Microsome http://togogenome.org/gene/9940:CAND1 ^@ http://purl.uniprot.org/uniprot/W5NVQ4 ^@ Similarity ^@ Belongs to the CAND family. http://togogenome.org/gene/9940:LDHAL6B ^@ http://purl.uniprot.org/uniprot/W5NXL6 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9940:GALNT5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E1R7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC51A ^@ http://purl.uniprot.org/uniprot/W5QGG9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:ATP5MC3 ^@ http://purl.uniprot.org/uniprot/W5NPR0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9940:TUBGCP5 ^@ http://purl.uniprot.org/uniprot/W5Q2M5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9940:LOC101121060 ^@ http://purl.uniprot.org/uniprot/W5PBB9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:TMC3 ^@ http://purl.uniprot.org/uniprot/W5Q2S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/9940:MLH1 ^@ http://purl.uniprot.org/uniprot/W5Q4Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||Nucleus http://togogenome.org/gene/9940:ALB ^@ http://purl.uniprot.org/uniprot/P14639 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the ALB/AFP/VDB family.|||Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-272 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).|||Interacts with FCGRT; this interaction regulates ALB homeostasis (By similarity). Interacts with TASOR (By similarity). In plasma, occurs in a covalently-linked complex with chromophore-bound alpha-1-microglobulin; this interaction does not prevent fatty acid binding to ALB.|||Phosphorylated by FAM20C in the extracellular medium.|||Plasma.|||Secreted http://togogenome.org/gene/9940:LOC101106041 ^@ http://purl.uniprot.org/uniprot/A0A835ZWN2 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPS27 ^@ http://purl.uniprot.org/uniprot/A0A836AQY8 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KCNG1 ^@ http://purl.uniprot.org/uniprot/W5PXL3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:TGM3 ^@ http://purl.uniprot.org/uniprot/W5PB04 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9940:APOA2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7G9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein A2 family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SKP1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQJ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SKP1 family.|||Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.|||Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.|||The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. http://togogenome.org/gene/9940:ALAS2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EH69|||http://purl.uniprot.org/uniprot/W5P6N1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPS3A ^@ http://purl.uniprot.org/uniprot/W5P6A3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.|||Cytoplasm|||May play a role during erythropoiesis through regulation of transcription factor DDIT3.|||Nucleus http://togogenome.org/gene/9940:COLGALT2 ^@ http://purl.uniprot.org/uniprot/A0A836A924|||http://purl.uniprot.org/uniprot/W5NWK3 ^@ Caution|||Similarity ^@ Belongs to the glycosyltransferase 25 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GPR85 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8V5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RALY ^@ http://purl.uniprot.org/uniprot/A0A6P3TJT0 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/9940:LOC101116514 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECT7|||http://purl.uniprot.org/uniprot/W5PGR2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101105185 ^@ http://purl.uniprot.org/uniprot/W5QCV3 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9940:GPX8 ^@ http://purl.uniprot.org/uniprot/W5PDN4 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9940:HAPLN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ED94 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||extracellular matrix http://togogenome.org/gene/9940:SLC5A7 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAY5|||http://purl.uniprot.org/uniprot/W5QIH8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LDB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDN4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LDB family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RAB4B ^@ http://purl.uniprot.org/uniprot/A0A6P3ECE4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NAGA ^@ http://purl.uniprot.org/uniprot/A0A6P3CWU6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/9940:HSP90AB1 ^@ http://purl.uniprot.org/uniprot/W5PHW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 90 family.|||Melanosome http://togogenome.org/gene/9940:P2RX5 ^@ http://purl.uniprot.org/uniprot/W5Q7S4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9940:HOXD10 ^@ http://purl.uniprot.org/uniprot/W5Q7V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9940:DHPS ^@ http://purl.uniprot.org/uniprot/A0A6P3EDJ4|||http://purl.uniprot.org/uniprot/W5PR99 ^@ Caution|||Similarity ^@ Belongs to the deoxyhypusine synthase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UFL1 ^@ http://purl.uniprot.org/uniprot/A0A836A4A7 ^@ Caution|||Similarity ^@ Belongs to the UFL1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PSMA6 ^@ http://purl.uniprot.org/uniprot/B6EBS6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9940:MIXL1 ^@ http://purl.uniprot.org/uniprot/W5NPE5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:BET1L ^@ http://purl.uniprot.org/uniprot/A0A6P3EFK9|||http://purl.uniprot.org/uniprot/W5PGY2 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:VPS37A ^@ http://purl.uniprot.org/uniprot/W5PI05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/9940:XPNPEP1 ^@ http://purl.uniprot.org/uniprot/W5PGW8 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/9940:MTX3 ^@ http://purl.uniprot.org/uniprot/W5Q7P9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9940:TMED3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EMM0|||http://purl.uniprot.org/uniprot/W5Q045 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cis-Golgi network membrane http://togogenome.org/gene/9940:PPP4R3A ^@ http://purl.uniprot.org/uniprot/A0A6P3EBY4|||http://purl.uniprot.org/uniprot/W5PR01 ^@ Caution|||Similarity ^@ Belongs to the SMEK family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PYGL ^@ http://purl.uniprot.org/uniprot/Q5MIB5 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation, which is up-regulated by glucose and insulin and down-regulated by glucagon, inhibits the glycogen phosphorylase activity by promoting PPP1R3B-mediated recruitment of phosphatase PP1 and Ser-15 dephosphorylation.|||Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Allosterically regulated through the non-covalent binding of metabolites, being activated by AMP and inhibited by ATP, ADP, and glucose-6-phosphate. The activity is also controlled by post-translational modifications including phosphorylation and acetylation.|||Belongs to the glycogen phosphorylase family.|||Homodimer; enzymatically active. Interacts with PPP1R3B; recruits the phosphatase PP1 which dephosphorylates and inactivates PYGL/glycogen phosphorylase.|||Phosphorylation at Ser-15 converts inactive phosphorylase b into active phosphorylase a. Dephosphorylation of Ser-15 by phosphatase PP1 inactivates the enzyme.|||cytosol http://togogenome.org/gene/9940:PAEP ^@ http://purl.uniprot.org/uniprot/P67976 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Alternate disulfide bonds occur in equal amounts.|||Belongs to the calycin superfamily. Lipocalin family.|||Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule.|||Secreted|||Under physiological conditions beta-lactoglobulin exists as an equilibrium mixture of monomeric and dimeric forms. http://togogenome.org/gene/9940:DGAT2L6 ^@ http://purl.uniprot.org/uniprot/A0A6P3EF30 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GRPR ^@ http://purl.uniprot.org/uniprot/A0A6P3EEU2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CISD3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDE0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:USP15 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7T5|||http://purl.uniprot.org/uniprot/W5P393 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UBE2G2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YIW7|||http://purl.uniprot.org/uniprot/W5PRP9 ^@ Caution|||Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRPC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E007|||http://purl.uniprot.org/uniprot/W5P7M3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. http://togogenome.org/gene/9940:CAPZA3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB64|||http://purl.uniprot.org/uniprot/W5QG90 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101113004 ^@ http://purl.uniprot.org/uniprot/W5PMZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tigger transposable element derived protein family.|||Nucleus http://togogenome.org/gene/9940:LOC101120955 ^@ http://purl.uniprot.org/uniprot/A0A6P3EP38 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRAPPC2 ^@ http://purl.uniprot.org/uniprot/W5PP20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/9940:XYLT2 ^@ http://purl.uniprot.org/uniprot/W5P3L6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 14 family. XylT subfamily.|||Golgi apparatus membrane|||Membrane|||Monomer. http://togogenome.org/gene/9940:GINS4 ^@ http://purl.uniprot.org/uniprot/A0A6P3YPY0|||http://purl.uniprot.org/uniprot/W5NWH8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Chromosome|||Nucleus|||Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HACD1 ^@ http://purl.uniprot.org/uniprot/Q9N1R5 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Expressed in heart.|||May interact with enzymes of the ELO family (including ELOVL1); with those enzymes that mediate condensation, the first of the four steps of the reaction cycle responsible for fatty acids elongation, may be part of a larger fatty acids elongase complex.|||N-glycosylated.|||Shares some similarity with tyrosine phosphatase proteins but it has probably no phosphatase activity. http://togogenome.org/gene/9940:MGAT1 ^@ http://purl.uniprot.org/uniprot/W5Q5G1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.|||Membrane|||The cofactor is mostly bound to the substrate. http://togogenome.org/gene/9940:ODF2L ^@ http://purl.uniprot.org/uniprot/A0A836AP48|||http://purl.uniprot.org/uniprot/W5PYS3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||centrosome http://togogenome.org/gene/9940:DBR1 ^@ http://purl.uniprot.org/uniprot/W5PCI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lariat debranching enzyme family.|||Nucleus http://togogenome.org/gene/9940:SOX14 ^@ http://purl.uniprot.org/uniprot/W5Q1Z3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:LOC101106767 ^@ http://purl.uniprot.org/uniprot/A0A6P3TFZ1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LIN52 ^@ http://purl.uniprot.org/uniprot/W5NS60 ^@ Similarity ^@ Belongs to the lin-52 family. http://togogenome.org/gene/9940:NNT ^@ http://purl.uniprot.org/uniprot/A0A571N6A6 ^@ Similarity ^@ In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/9940:AKAP4 ^@ http://purl.uniprot.org/uniprot/A0A6P3TAY9|||http://purl.uniprot.org/uniprot/W5PJZ7 ^@ Caution|||Similarity ^@ Belongs to the AKAP110 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POLR3H ^@ http://purl.uniprot.org/uniprot/W5QAB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9940:MMP20 ^@ http://purl.uniprot.org/uniprot/W5P7K9 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9940:COG4 ^@ http://purl.uniprot.org/uniprot/W5P4D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG4 family.|||Golgi apparatus membrane http://togogenome.org/gene/9940:GAS8 ^@ http://purl.uniprot.org/uniprot/W5Q110 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC4 family.|||flagellum axoneme http://togogenome.org/gene/9940:RNF14 ^@ http://purl.uniprot.org/uniprot/A0A6P3TE22 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101107469 ^@ http://purl.uniprot.org/uniprot/W5PC45 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:C7H15orf61 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEI7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLA2G4B ^@ http://purl.uniprot.org/uniprot/W5QGU7 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9940:MDK ^@ http://purl.uniprot.org/uniprot/W5P004 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/9940:RAB4A ^@ http://purl.uniprot.org/uniprot/A0A6P3CXG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. http://togogenome.org/gene/9940:POLR2C ^@ http://purl.uniprot.org/uniprot/A0A6P3EL09|||http://purl.uniprot.org/uniprot/W5NQ60 ^@ Caution|||Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PDE6G ^@ http://purl.uniprot.org/uniprot/A0A6P3EDT0 ^@ Caution|||Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101109838 ^@ http://purl.uniprot.org/uniprot/A0A836AFM0|||http://purl.uniprot.org/uniprot/W5PWL0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uricase family.|||Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.|||Peroxisome|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101103181 ^@ http://purl.uniprot.org/uniprot/A0A836A0T5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZNF821 ^@ http://purl.uniprot.org/uniprot/A0A6P3TKB7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STAR ^@ http://purl.uniprot.org/uniprot/A0A835ZN77|||http://purl.uniprot.org/uniprot/P79245 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ May interact with TSPO.|||Mitochondrion|||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity).|||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM11 ^@ http://purl.uniprot.org/uniprot/A0A6P3EA54|||http://purl.uniprot.org/uniprot/W5NWY1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM11 family.|||Membrane|||Mitochondrion inner membrane|||Plays a role in mitochondrial morphogenesis.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BRIX1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENF2|||http://purl.uniprot.org/uniprot/W5PPJ4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BRX1 family.|||Required for biogenesis of the 60S ribosomal subunit.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:PSPH ^@ http://purl.uniprot.org/uniprot/B2LU26 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/9940:RFK ^@ http://purl.uniprot.org/uniprot/A0A6P3YHL8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPL35A ^@ http://purl.uniprot.org/uniprot/A0A836AQ54 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPP1R11 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQ18|||http://purl.uniprot.org/uniprot/W5Q4B9 ^@ Caution|||Subunit ^@ Interacts with TLR2 and UBE2D2.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101120103 ^@ http://purl.uniprot.org/uniprot/A0A835ZTV1 ^@ Caution|||Similarity ^@ Belongs to the sulfotransferase 1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DLX3 ^@ http://purl.uniprot.org/uniprot/C0L2S3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/9940:PIK3C3 ^@ http://purl.uniprot.org/uniprot/A0A6P3ER65 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.|||Midbody|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC26A3 ^@ http://purl.uniprot.org/uniprot/D6QUQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Cell membrane|||Chloride/bicarbonate exchanger.|||Membrane http://togogenome.org/gene/9940:C25H10orf53 ^@ http://purl.uniprot.org/uniprot/W5NVQ3 ^@ Similarity ^@ Belongs to the UPF0728 family. http://togogenome.org/gene/9940:STRADA ^@ http://purl.uniprot.org/uniprot/A0A6P3CXH8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DIO3 ^@ http://purl.uniprot.org/uniprot/Q6DN07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the iodothyronine deiodinase family.|||Cell membrane|||Endosome membrane|||Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. http://togogenome.org/gene/9940:TLR4 ^@ http://purl.uniprot.org/uniprot/B5DC89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9940:NRF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TG79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRF1/Ewg family.|||Nucleus http://togogenome.org/gene/9940:PDAP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YPH6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PAK1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJX5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101103947 ^@ http://purl.uniprot.org/uniprot/W5P7S6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Functions as transport protein in the blood stream.|||Secreted http://togogenome.org/gene/9940:C9H8orf76 ^@ http://purl.uniprot.org/uniprot/A0A6P3EG82 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EBPL ^@ http://purl.uniprot.org/uniprot/W5PFJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9940:LOC101108931 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHQ7|||http://purl.uniprot.org/uniprot/W5Q8W8 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:APPBP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9M7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LANCL1 ^@ http://purl.uniprot.org/uniprot/W5QD23 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/9940:CYP17 ^@ http://purl.uniprot.org/uniprot/W5NVQ8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9940:POU2F3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YQF2|||http://purl.uniprot.org/uniprot/J7IHV5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-2 subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BCO2 ^@ http://purl.uniprot.org/uniprot/W5Q4D5 ^@ Similarity ^@ Belongs to the carotenoid oxygenase family. http://togogenome.org/gene/9940:STARD3NL ^@ http://purl.uniprot.org/uniprot/A0A6P3TR98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9940:ATP6V0B ^@ http://purl.uniprot.org/uniprot/A0A6P3E676 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9940:PLAGL2 ^@ http://purl.uniprot.org/uniprot/A0A835ZU85 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CACNA1D ^@ http://purl.uniprot.org/uniprot/W5Q3W6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.|||Membrane|||Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. http://togogenome.org/gene/9940:SLC17A5 ^@ http://purl.uniprot.org/uniprot/Q9MZD1|||http://purl.uniprot.org/uniprot/W5P894 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.|||Lysosome membrane|||Membrane|||Primary solute translocator for anionic substances; particularly it is a free sialic acid transporter in the lysosomes (Probable). Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties.|||Significantly expressed in lung endothelial cells, and much less in liver. http://togogenome.org/gene/9940:PSMB10 ^@ http://purl.uniprot.org/uniprot/A0A6P3EL31|||http://purl.uniprot.org/uniprot/W5NZ57 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CETN2 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQM8 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/9940:PYCR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YNX0 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/9940:UTP6 ^@ http://purl.uniprot.org/uniprot/W5PVG8 ^@ Similarity ^@ Belongs to the UTP6 family. http://togogenome.org/gene/9940:ATP5PD ^@ http://purl.uniprot.org/uniprot/B7P027 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase d subunit family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/9940:PDE6D ^@ http://purl.uniprot.org/uniprot/A0A6P3EA65 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PDE6D/unc-119 family.|||Cytoplasmic vesicle membrane|||Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.|||Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cilium basal body|||cytosol http://togogenome.org/gene/9940:PUS1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQP1|||http://purl.uniprot.org/uniprot/W5PUZ2 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/9940:LOC101118999 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENY7 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARMC8 ^@ http://purl.uniprot.org/uniprot/A0A6P3YJD4 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAM167A ^@ http://purl.uniprot.org/uniprot/A0A836D910 ^@ Caution|||Similarity ^@ Belongs to the FAM167 (SEC) family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CHRNA6 ^@ http://purl.uniprot.org/uniprot/W5NZZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9940:EFTUD2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDN7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UBXN10 ^@ http://purl.uniprot.org/uniprot/A0A836D775 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRMT7 ^@ http://purl.uniprot.org/uniprot/A0A6P3EL40|||http://purl.uniprot.org/uniprot/A0A6P7ERX0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytosol http://togogenome.org/gene/9940:TMEM169 ^@ http://purl.uniprot.org/uniprot/A0A836AN88 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMSB15B ^@ http://purl.uniprot.org/uniprot/W5NQY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9940:LOC101105324 ^@ http://purl.uniprot.org/uniprot/A0A6P3E498|||http://purl.uniprot.org/uniprot/A0A6P7E0Q2 ^@ Caution|||Similarity ^@ Belongs to the Luc7 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARMC1 ^@ http://purl.uniprot.org/uniprot/W5Q6F2 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9940:CCDC32 ^@ http://purl.uniprot.org/uniprot/A0A836D1H0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC46A3 ^@ http://purl.uniprot.org/uniprot/W5PR93 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:DNAJC16 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8S3 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ANKRD49 ^@ http://purl.uniprot.org/uniprot/A0A6P3EK24 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GLYCAM1 ^@ http://purl.uniprot.org/uniprot/W5Q3I2 ^@ Similarity ^@ Belongs to the PP3/GlyCAM-1 family. http://togogenome.org/gene/9940:GLS2 ^@ http://purl.uniprot.org/uniprot/A0A836D574|||http://purl.uniprot.org/uniprot/W5PFS4 ^@ Caution|||Similarity ^@ Belongs to the glutaminase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DYNC2H1 ^@ http://purl.uniprot.org/uniprot/W5P0H6 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/9940:LOC101102548 ^@ http://purl.uniprot.org/uniprot/W5Q4K3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9940:ATP8B4 ^@ http://purl.uniprot.org/uniprot/W5QIL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9940:MAP3K7 ^@ http://purl.uniprot.org/uniprot/W5PRX8|||http://purl.uniprot.org/uniprot/W5PRX9 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.|||Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Cytoplasm http://togogenome.org/gene/9940:TOMT ^@ http://purl.uniprot.org/uniprot/A0A6P9FRH4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.|||Endoplasmic reticulum|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101108696 ^@ http://purl.uniprot.org/uniprot/A8IW63 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9940:METTL14 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6K8|||http://purl.uniprot.org/uniprot/W5Q720 ^@ Caution|||Similarity ^@ Belongs to the MT-A70-like family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC12A4 ^@ http://purl.uniprot.org/uniprot/Q7YS96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9940:FGF2 ^@ http://purl.uniprot.org/uniprot/P20003 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Also acts as an integrin ligand which is required for FGF2 signaling (By similarity). Binds to integrin ITGAV:ITGB3 (By similarity). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (By similarity). Functions as a potent mitogen in vitro (By similarity). Can induce angiogenesis (By similarity). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (By similarity).|||Belongs to the heparin-binding growth factors family.|||Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP3. Interacts with integrin ITGAV:ITGB3; the interaction is required for FGF2 signaling. Interacts with SNORC (via the extracellular domain). Interacts with glypican GPC3 (By similarity).|||Nucleus|||Phosphorylation at Tyr-82 regulates FGF2 unconventional secretion.|||Secreted http://togogenome.org/gene/9940:RIC3 ^@ http://purl.uniprot.org/uniprot/W5Q087 ^@ Similarity ^@ Belongs to the ric-3 family. http://togogenome.org/gene/9940:LCTL ^@ http://purl.uniprot.org/uniprot/A0A835ZZU4 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DPAGT1 ^@ http://purl.uniprot.org/uniprot/A0A835ZR68 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family.|||Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.|||Endoplasmic reticulum membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAM199X ^@ http://purl.uniprot.org/uniprot/W5NR24 ^@ Similarity ^@ Belongs to the FAM199 family. http://togogenome.org/gene/9940:NOL9 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8R1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC114108604 ^@ http://purl.uniprot.org/uniprot/A4ZVY9|||http://purl.uniprot.org/uniprot/Q6QAT4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta-2-microglobulin family.|||Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).|||Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).|||Secreted http://togogenome.org/gene/9940:POLR1C ^@ http://purl.uniprot.org/uniprot/A0A6P3EJ63|||http://purl.uniprot.org/uniprot/A0A6P3TEI3 ^@ Caution|||Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TNFAIP6 ^@ http://purl.uniprot.org/uniprot/W5PGW9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:GZMM ^@ http://purl.uniprot.org/uniprot/A0A6P3YLU6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MMADHC ^@ http://purl.uniprot.org/uniprot/A0A836D6Q0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KIAA1191 ^@ http://purl.uniprot.org/uniprot/W5Q4V4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P33MONOX family.|||Cytoplasm|||Interacts with NELFB, NOL12 and PRNP.|||Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth. http://togogenome.org/gene/9940:MTREX ^@ http://purl.uniprot.org/uniprot/A0A6P3EB49 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HDDC3 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENX1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RALB ^@ http://purl.uniprot.org/uniprot/A0A6P7DQB7 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/9940:INTS3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E603|||http://purl.uniprot.org/uniprot/W5NSM6 ^@ Caution|||Similarity ^@ Belongs to the Integrator subunit 3 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CHP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAY4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PARP11 ^@ http://purl.uniprot.org/uniprot/W5PKZ8 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9940:PGM5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5Z2|||http://purl.uniprot.org/uniprot/W5PUA9 ^@ Caution|||Similarity ^@ Belongs to the phosphohexose mutase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SKAP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YHL0|||http://purl.uniprot.org/uniprot/W5PJQ2 ^@ Caution|||Similarity ^@ Belongs to the SKAP family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GRK7 ^@ http://purl.uniprot.org/uniprot/W5P987 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9940:HYOU1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TBL3 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9940:KEF53_p12 ^@ http://purl.uniprot.org/uniprot/O78748|||http://purl.uniprot.org/uniprot/Q5MA76 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 2 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242 (By similarity).|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9940:UBQLN2 ^@ http://purl.uniprot.org/uniprot/W5P682 ^@ Subcellular Location Annotation ^@ Membrane|||Nucleus|||autophagosome http://togogenome.org/gene/9940:ACP1 ^@ http://purl.uniprot.org/uniprot/W5P582|||http://purl.uniprot.org/uniprot/W5P583 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.|||Belongs to the low molecular weight phosphotyrosine protein phosphatase family.|||Cytoplasm http://togogenome.org/gene/9940:LOC101116302 ^@ http://purl.uniprot.org/uniprot/A0A836A542|||http://purl.uniprot.org/uniprot/W5P2W9 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||Component of the 40S ribosomal subunit.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C1H21orf62 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZY0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101108797 ^@ http://purl.uniprot.org/uniprot/A0A6P7DGJ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the globin family.|||Heterotetramer of two alpha chains and two beta chains.|||Involved in oxygen transport from the lung to the various peripheral tissues. http://togogenome.org/gene/9940:HCK ^@ http://purl.uniprot.org/uniprot/W5NXU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9940:RPSA ^@ http://purl.uniprot.org/uniprot/A6YRY8 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity.|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/9940:ORAI2 ^@ http://purl.uniprot.org/uniprot/A0A6P3T5Y4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Orai family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TEX261 ^@ http://purl.uniprot.org/uniprot/A0A6P3YGW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVP26 family.|||Membrane http://togogenome.org/gene/9940:CBLN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9J7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC5A12 ^@ http://purl.uniprot.org/uniprot/W5PYF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9940:PAN2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAS8 ^@ Activity Regulation|||Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. PAN2 subfamily.|||Binds 2 metal cations per subunit in the catalytic exonuclease domain.|||Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.|||Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.|||Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts with ZFP36.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||P-body|||Positively regulated by the regulatory subunit PAN3.|||The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TUBAL3 ^@ http://purl.uniprot.org/uniprot/W5PH73 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains (PubMed:6504138, PubMed:2207090, PubMed:7704569). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:6504138, PubMed:2207090, PubMed:7704569). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:6504138, PubMed:2207090, PubMed:7704569).|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/9940:HBEGF ^@ http://purl.uniprot.org/uniprot/A0A6P3E9M8|||http://purl.uniprot.org/uniprot/W5Q7W2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ANGPTL4 ^@ http://purl.uniprot.org/uniprot/W6AX51 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9940:POLD4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EK96 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ROPN1L ^@ http://purl.uniprot.org/uniprot/A0A6P3EHK2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM127 ^@ http://purl.uniprot.org/uniprot/A0A836ACL3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OCEL1 ^@ http://purl.uniprot.org/uniprot/W5Q8H5 ^@ Similarity ^@ Belongs to the ELL/occludin family. http://togogenome.org/gene/9940:RWDD4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEP3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GPR61 ^@ http://purl.uniprot.org/uniprot/A0A836D9S7 ^@ Caution|||Similarity ^@ Belongs to the G-protein coupled receptor 1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DUOX2 ^@ http://purl.uniprot.org/uniprot/D7REY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.|||In the N-terminal section; belongs to the peroxidase family.|||Membrane http://togogenome.org/gene/9940:NOL11 ^@ http://purl.uniprot.org/uniprot/W5Q2J3 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9940:TNFSF8 ^@ http://purl.uniprot.org/uniprot/A0A6P3E0U5|||http://purl.uniprot.org/uniprot/W5P7H7 ^@ Caution|||Similarity ^@ Belongs to the tumor necrosis factor family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PIMREG ^@ http://purl.uniprot.org/uniprot/A0A6P3ED15 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLRG1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TG74|||http://purl.uniprot.org/uniprot/W5NRL3 ^@ Caution|||Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CYP2E1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQP0|||http://purl.uniprot.org/uniprot/F1CGV3 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.|||Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.|||Microsome membrane|||Mitochondrion inner membrane|||The omega-1 hydroxylase activity is stimulated by cytochrome b5.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101110434 ^@ http://purl.uniprot.org/uniprot/W5PSE5 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9940:SLPI ^@ http://purl.uniprot.org/uniprot/Q6V9X0 ^@ Function|||Induction|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (By similarity).|||Detected in bronchoalveolar fluid (at protein level). Detected in large and small intestine, trachea, skin, lung and tongue.|||Interacts with GRN; interaction protects progranulin from proteolysis.|||Secreted|||Up-regulated in response to bacterial lipopolysaccharide (LPS) in bronchoalveolar fluid (at protein level). http://togogenome.org/gene/9940:LOC101103208 ^@ http://purl.uniprot.org/uniprot/A0A836CQK8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sesquipedalian family.|||Early endosome|||Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.|||Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.|||Recycling endosome|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/9940:CDH9 ^@ http://purl.uniprot.org/uniprot/W5PT37 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:PTER ^@ http://purl.uniprot.org/uniprot/A0A836A776|||http://purl.uniprot.org/uniprot/W5PGQ7 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.|||Binds 2 divalent metal cations per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101107135 ^@ http://purl.uniprot.org/uniprot/A0A6P3EH31|||http://purl.uniprot.org/uniprot/W5PQR4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FBXO25 ^@ http://purl.uniprot.org/uniprot/A0A6P7DER7|||http://purl.uniprot.org/uniprot/W5PVK5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:LMOD3 ^@ http://purl.uniprot.org/uniprot/A0A6P3T313|||http://purl.uniprot.org/uniprot/A0A6P3TBJ2 ^@ Caution|||Subcellular Location Annotation ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytoskeleton|||sarcomere http://togogenome.org/gene/9940:LOC101110649 ^@ http://purl.uniprot.org/uniprot/A0A835ZJ51|||http://purl.uniprot.org/uniprot/K4P217 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL22 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101117005 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE27|||http://purl.uniprot.org/uniprot/W5P514 ^@ Caution|||Similarity ^@ Belongs to the COX20 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GDI2 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQJ0|||http://purl.uniprot.org/uniprot/C5IJ88 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101106658 ^@ http://purl.uniprot.org/uniprot/A0A6P7DM26|||http://purl.uniprot.org/uniprot/V9GZC0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZDHHC6 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQ63 ^@ Caution|||Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RND3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E1S8|||http://purl.uniprot.org/uniprot/W5PHI3 ^@ Caution|||Function ^@ Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:G2E3 ^@ http://purl.uniprot.org/uniprot/A0A6P3T6R2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TLR5 ^@ http://purl.uniprot.org/uniprot/B5DC90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9940:LOC101122977 ^@ http://purl.uniprot.org/uniprot/W5PBK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:NAIF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E2D1|||http://purl.uniprot.org/uniprot/W5PMT7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAIF1 family.|||Induces apoptosis.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCDC126 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4L1|||http://purl.uniprot.org/uniprot/A0A6P3TMQ1 ^@ Caution|||Subcellular Location Annotation ^@ Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NPBWR2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EIT7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101120489 ^@ http://purl.uniprot.org/uniprot/A0A6P3EA32|||http://purl.uniprot.org/uniprot/W5NTE7 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL6 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARHGDIB ^@ http://purl.uniprot.org/uniprot/W5QHP6 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/9940:LEF1 ^@ http://purl.uniprot.org/uniprot/W5PDZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/9940:TSSK4 ^@ http://purl.uniprot.org/uniprot/A0A6P3TFE7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LIPH ^@ http://purl.uniprot.org/uniprot/A0A6P3E816|||http://purl.uniprot.org/uniprot/W5QH96 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PEX5L ^@ http://purl.uniprot.org/uniprot/A0A836AFH3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal targeting signal receptor family.|||Cytoplasm|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CATHL1B ^@ http://purl.uniprot.org/uniprot/A0A6P7D5A0|||http://purl.uniprot.org/uniprot/P54230 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Potent microbicidal activity; active against S.aureus and E.coli.|||Secreted http://togogenome.org/gene/9940:GBA ^@ http://purl.uniprot.org/uniprot/W5P1A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 30 family.|||Lysosome membrane http://togogenome.org/gene/9940:TUBB1 ^@ http://purl.uniprot.org/uniprot/W5Q3I7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9940:DDIT4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGR1|||http://purl.uniprot.org/uniprot/W5PB57 ^@ Caution|||Similarity ^@ Belongs to the DDIT4 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMCO1 ^@ http://purl.uniprot.org/uniprot/W5PPH9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TMCO1 family.|||Calcium-selective channel required to prevent calcium stores from overfilling.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homodimer and homotetramer. Homodimer under resting conditions; forms homotetramers following and ER calcium overload.|||Membrane http://togogenome.org/gene/9940:FAM219B ^@ http://purl.uniprot.org/uniprot/W5NY39 ^@ Similarity ^@ Belongs to the FAM219 family. http://togogenome.org/gene/9940:MRPL32 ^@ http://purl.uniprot.org/uniprot/W5Q7B1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/9940:GHRL ^@ http://purl.uniprot.org/uniprot/Q863L0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the motilin family.|||Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.|||O-octanoylation is essential for ghrelin activity.|||Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.|||Secreted http://togogenome.org/gene/9940:CHMP2A ^@ http://purl.uniprot.org/uniprot/A0A6P3EA09|||http://purl.uniprot.org/uniprot/A0A6P3EFY0 ^@ Caution|||Similarity ^@ Belongs to the SNF7 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MKLN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E573 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CSTF2 ^@ http://purl.uniprot.org/uniprot/W5NSC2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:CCDC22 ^@ http://purl.uniprot.org/uniprot/W5PL73 ^@ Similarity ^@ Belongs to the CCDC22 family. http://togogenome.org/gene/9940:PPOX ^@ http://purl.uniprot.org/uniprot/W5PIT5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.|||Binds 1 FAD per subunit.|||Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.|||Mitochondrion inner membrane http://togogenome.org/gene/9940:FABP12 ^@ http://purl.uniprot.org/uniprot/W5PI01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm http://togogenome.org/gene/9940:PLN ^@ http://purl.uniprot.org/uniprot/W5QFE3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phospholamban family.|||Endoplasmic reticulum membrane|||Homopentamer.|||Membrane|||Mitochondrion membrane|||Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9940:ACTR1A ^@ http://purl.uniprot.org/uniprot/A0A6P3EFT3|||http://purl.uniprot.org/uniprot/W5NSM1 ^@ Caution|||Similarity ^@ Belongs to the actin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GPI ^@ http://purl.uniprot.org/uniprot/W5P323 ^@ Similarity ^@ Belongs to the GPI family. http://togogenome.org/gene/9940:RBPJ ^@ http://purl.uniprot.org/uniprot/A0A6P3TN17|||http://purl.uniprot.org/uniprot/U5PR56 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Su(H) family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MYL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EA17 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MS4A13 ^@ http://purl.uniprot.org/uniprot/W5PUE2 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9940:RSPO2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YN12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the R-spondin family.|||Secreted http://togogenome.org/gene/9940:EIF4A3 ^@ http://purl.uniprot.org/uniprot/W5NVU4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9940:LSM12 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAH2 ^@ Caution|||Similarity ^@ Belongs to the LSM12 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DRAP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQN1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TP53BP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE12 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPP2R1B ^@ http://purl.uniprot.org/uniprot/A0A6P3EK56 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101105868 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZI2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LIPA ^@ http://purl.uniprot.org/uniprot/B2LSM5 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9940:CSTF3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAK2 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TLR2 ^@ http://purl.uniprot.org/uniprot/Q09I12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides.|||Membrane|||Membrane raft|||phagosome membrane http://togogenome.org/gene/9940:COPS8 ^@ http://purl.uniprot.org/uniprot/A0A6P3TGL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN8 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9940:C22H10orf90 ^@ http://purl.uniprot.org/uniprot/W5PSX1 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/9940:LRRFIP1 ^@ http://purl.uniprot.org/uniprot/W5QCH0 ^@ Similarity ^@ Belongs to the LRRFIP family. http://togogenome.org/gene/9940:IKZF5 ^@ http://purl.uniprot.org/uniprot/A0A6P3EKY3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRLN ^@ http://purl.uniprot.org/uniprot/A0A6P9FRI4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC41A2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E825 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9940:TEKT3 ^@ http://purl.uniprot.org/uniprot/W5Q4X8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9940:ING1 ^@ http://purl.uniprot.org/uniprot/W5PAR4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9940:LOC101102344 ^@ http://purl.uniprot.org/uniprot/A0A835ZVV9|||http://purl.uniprot.org/uniprot/W5QFN5 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HOXC9 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBG6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLK3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBV4 ^@ Caution|||Similarity ^@ Belongs to the protein kinase superfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NBN ^@ http://purl.uniprot.org/uniprot/A0A836AB93 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.|||Component of the MRN complex.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||telomere http://togogenome.org/gene/9940:PPIL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENI7 ^@ Caution|||Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HRH4 ^@ http://purl.uniprot.org/uniprot/W5PBL0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9940:MTFR1L ^@ http://purl.uniprot.org/uniprot/A0A6P3T9T5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101107433 ^@ http://purl.uniprot.org/uniprot/W5Q9J2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:NAP1L4 ^@ http://purl.uniprot.org/uniprot/A0A835ZN33 ^@ Caution|||Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IFT22 ^@ http://purl.uniprot.org/uniprot/A0A6P3ELV4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NDUFA10 ^@ http://purl.uniprot.org/uniprot/A0A8N7XJK5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA10 subunit family.|||Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.|||Mitochondrion matrix|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ANGPTL5 ^@ http://purl.uniprot.org/uniprot/A0A6P3EK39 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RAB7B ^@ http://purl.uniprot.org/uniprot/A0A6P3EDY6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TM4SF4 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZZ4|||http://purl.uniprot.org/uniprot/W5P442 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SESN3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YLX1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GLG1 ^@ http://purl.uniprot.org/uniprot/W5P6V4 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Golgi outpost|||Membrane|||microtubule organizing center http://togogenome.org/gene/9940:SMIM12 ^@ http://purl.uniprot.org/uniprot/A0A6P3TTV3 ^@ Similarity ^@ Belongs to the SMIM12 family. http://togogenome.org/gene/9940:CITED2 ^@ http://purl.uniprot.org/uniprot/K4PF77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CITED family.|||Nucleus http://togogenome.org/gene/9940:LOC101111904 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAV3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RABGGTB ^@ http://purl.uniprot.org/uniprot/C5IJ91 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX. http://togogenome.org/gene/9940:WNT5A ^@ http://purl.uniprot.org/uniprot/W5Q1D2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9940:TMEM8B ^@ http://purl.uniprot.org/uniprot/W5PQ14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:TES ^@ http://purl.uniprot.org/uniprot/A0A836AA40|||http://purl.uniprot.org/uniprot/Q09YJ2 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prickle / espinas / testin family.|||Cytoplasm|||Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer (By similarity).|||Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer.|||Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity).|||Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor.|||The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||focal adhesion http://togogenome.org/gene/9940:BIRC2 ^@ http://purl.uniprot.org/uniprot/W5P941 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9940:TAS2R4 ^@ http://purl.uniprot.org/uniprot/A0A6P3TGA4|||http://purl.uniprot.org/uniprot/W5NSX7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cilium membrane http://togogenome.org/gene/9940:VPS33A ^@ http://purl.uniprot.org/uniprot/A0A6P3ENM5|||http://purl.uniprot.org/uniprot/W5PPJ2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||clathrin-coated vesicle http://togogenome.org/gene/9940:FBXO6 ^@ http://purl.uniprot.org/uniprot/A0A835ZZH0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101120486 ^@ http://purl.uniprot.org/uniprot/W5QGE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9940:TTC33 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB65 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LSM5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8X2|||http://purl.uniprot.org/uniprot/W5PAH8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KCNB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9E7|||http://purl.uniprot.org/uniprot/W5PSR3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.|||Lateral cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synaptic cell membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||axon|||sarcolemma|||synaptosome http://togogenome.org/gene/9940:AFAP1L1 ^@ http://purl.uniprot.org/uniprot/A0A836AG06 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in podosome and invadosome formation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||invadopodium|||podosome http://togogenome.org/gene/9940:CCNT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7Q3|||http://purl.uniprot.org/uniprot/W5QD24 ^@ Caution|||Similarity ^@ Belongs to the cyclin family. Cyclin C subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TFRC ^@ http://purl.uniprot.org/uniprot/A0A6P3E4Z4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.|||Homodimer; disulfide-linked.|||Melanosome|||Membrane|||Stearoylated. http://togogenome.org/gene/9940:KCNMB1 ^@ http://purl.uniprot.org/uniprot/W5NZ82 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9940:CNPY4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEB0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101120367 ^@ http://purl.uniprot.org/uniprot/W5Q127 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9940:LRRC51 ^@ http://purl.uniprot.org/uniprot/A0A6P3TBC4|||http://purl.uniprot.org/uniprot/W5P0W1 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ETNK1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TC20 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMBIM6 ^@ http://purl.uniprot.org/uniprot/W5QAE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9940:ANKIB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3V6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GPHN ^@ http://purl.uniprot.org/uniprot/A0A6P3E7Y9 ^@ Caution|||Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.|||In the C-terminal section; belongs to the MoeA family.|||In the N-terminal section; belongs to the MoaB/Mog family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101113715 ^@ http://purl.uniprot.org/uniprot/W5PCU3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Secreted http://togogenome.org/gene/9940:CLVS2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TJC1 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Vesicle|||clathrin-coated vesicle|||trans-Golgi network membrane http://togogenome.org/gene/9940:ABRAXAS2 ^@ http://purl.uniprot.org/uniprot/W5PLJ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:ENOPH1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE57 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.|||Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Monomer.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101113526 ^@ http://purl.uniprot.org/uniprot/W5Q6Y9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:FAM71B ^@ http://purl.uniprot.org/uniprot/A0A6P3E9S8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CPA6 ^@ http://purl.uniprot.org/uniprot/W5NU87 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9940:YIF1A ^@ http://purl.uniprot.org/uniprot/A0A6P3EFJ4|||http://purl.uniprot.org/uniprot/W5P0C3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:THBS3 ^@ http://purl.uniprot.org/uniprot/W5P162 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:P4HA2 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9940:MZT2B ^@ http://purl.uniprot.org/uniprot/A0A6P3EBN2|||http://purl.uniprot.org/uniprot/W5Q617 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MOZART2 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||centrosome|||spindle http://togogenome.org/gene/9940:IL3 ^@ http://purl.uniprot.org/uniprot/Q06435 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Activated T-cells, mast cells, natural killer cells.|||Belongs to the IL-3 family.|||Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.|||Monomer.|||Secreted|||This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. http://togogenome.org/gene/9940:PIGH ^@ http://purl.uniprot.org/uniprot/A0A6P3E7Z5|||http://purl.uniprot.org/uniprot/W5QJ53 ^@ Caution|||Similarity ^@ Belongs to the PIGH family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GIMAP2 ^@ http://purl.uniprot.org/uniprot/W5NTW4 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9940:CA14 ^@ http://purl.uniprot.org/uniprot/W5QHX7 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/9940:NTS ^@ http://purl.uniprot.org/uniprot/W5Q1D7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurotensin family.|||Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/9940:SUPT7L ^@ http://purl.uniprot.org/uniprot/A0A836D4F8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ACAP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YFE6 ^@ Activity Regulation|||Caution|||Domain|||Function|||Subcellular Location Annotation ^@ Endosome membrane|||GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.|||GTPase-activating protein for the ADP ribosylation factor family.|||PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.|||The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC39A3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TDB3|||http://purl.uniprot.org/uniprot/B2MVY1 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NIT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TKB8 ^@ Caution|||Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NOP58 ^@ http://purl.uniprot.org/uniprot/A0A6P3THV3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:RBBP8 ^@ http://purl.uniprot.org/uniprot/W5PEG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COM1/SAE2/CtIP family.|||Nucleus http://togogenome.org/gene/9940:TDRD3 ^@ http://purl.uniprot.org/uniprot/W5P8D4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. http://togogenome.org/gene/9940:HOXC10 ^@ http://purl.uniprot.org/uniprot/W5Q495 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9940:CD28 ^@ http://purl.uniprot.org/uniprot/O97630 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:ARSL ^@ http://purl.uniprot.org/uniprot/W5PFA5 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9940:CCNB3 ^@ http://purl.uniprot.org/uniprot/W5PJK4 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9940:LSM3 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECF8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POLR3B ^@ http://purl.uniprot.org/uniprot/A0A6P3E830 ^@ Caution|||Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PEX2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TQH4 ^@ Function|||Similarity ^@ Belongs to the pex2/pex10/pex12 family.|||Somewhat implicated in the biogenesis of peroxisomes. http://togogenome.org/gene/9940:TNFRSF11B ^@ http://purl.uniprot.org/uniprot/A0A6P3EGC4 ^@ Caution|||Function|||Subunit ^@ Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101123544 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8D4|||http://purl.uniprot.org/uniprot/W5PWY3 ^@ Caution|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KCNA2 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZ92|||http://purl.uniprot.org/uniprot/W5PQ46 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.|||Cell membrane|||Membrane|||Presynaptic cell membrane|||Synaptic cell membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||lamellipodium membrane|||paranodal septate junction|||synaptosome http://togogenome.org/gene/9940:SDR9C7 ^@ http://purl.uniprot.org/uniprot/W5PDY4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9940:AK5 ^@ http://purl.uniprot.org/uniprot/W5PTS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/9940:FSHB ^@ http://purl.uniprot.org/uniprot/P01227 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer. The active follitropin is a heterodimer composed of an alpha chain/CGA shared with other hormones and a unique beta chain/FSHB shown here.|||Secreted|||Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. http://togogenome.org/gene/9940:BTG3 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQP2|||http://purl.uniprot.org/uniprot/F4MJ46 ^@ Caution|||Similarity ^@ Belongs to the BTG family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101116064 ^@ http://purl.uniprot.org/uniprot/W5PF89 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9940:MAP1LC3C ^@ http://purl.uniprot.org/uniprot/W5PAW4 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9940:WDR5B ^@ http://purl.uniprot.org/uniprot/A0A6P3E6S6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TGFB1 ^@ http://purl.uniprot.org/uniprot/P50414 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked. Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction.|||Homodimer; disulfide-linked. Interacts with the serine proteases, HTRA1 and HTRA3: the interaction with either inhibits TGFB1-mediated signaling and the HTRA protease activity is required for this inhibition. May interact with THSD4; this interaction may lead to sequestration by FBN1 microfibril assembly and attenuation of TGFB signaling. Interacts with CD109, DPT and ASPN. Interacts with EFEMP2. Interacts with TSKU; the interaction contributes to regulation of the hair cycle.|||Homodimer; disulfide-linked. Interacts with transforming growth factor beta-1 (TGF-beta-1) chain; interaction is non-covalent and maintains TGF-beta-1 in a latent state; each latency-associated peptide (LAP) monomer interacts with TGF-beta-1 in the other monomer. Interacts with LTBP1; leading to regulation of TGF-beta-1 activation. Interacts with LRRC32/GARP; leading to regulation of TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs). Interacts with LRRC33/NRROS; leading to regulation of TGF-beta-1 activation in macrophages and microglia. Interacts (via cell attachment site) with integrins ITGAV and ITGB6 (ITGAV:ITGB6), leading to release of the active TGF-beta-1. Interacts with NREP; the interaction results in a decrease in TGFB1 autoinduction. Interacts with HSP90AB1; inhibits latent TGFB1 activation.|||Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains remain non-covalently linked rendering TGF-beta-1 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS that control activation of TGF-beta-1 and maintain it in a latent state during storage in extracellular milieus. TGF-beta-1 is released from LAP by integrins (ITGAV:ITGB6 or ITGAV:ITGB8): integrin-binding to LAP stabilizes an alternative conformation of the LAP bowtie tail and results in distortion of the LAP chain and subsequent release of the active TGF-beta-1. Once activated following release of LAP, TGF-beta-1 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). While expressed by many cells types, TGF-beta-1 only has a very localized range of action within cell environment thanks to fine regulation of its activation by Latency-associated peptide chain (LAP) and 'milieu molecules'. Plays an important role in bone remodeling: acts as a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP). Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (By similarity).|||N-glycosylated. Deglycosylation leads to activation of Transforming growth factor beta-1 (TGF-beta-1); mechanisms triggering deglycosylation-driven activation of TGF-beta-1 are however unclear.|||Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia. Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs). Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1.|||Secreted|||The 'straitjacket' and 'arm' domains encircle the Transforming growth factor beta-1 (TGF-beta-1) monomers and are fastened together by strong bonding between Lys-56 and Tyr-103/Tyr-104.|||The cell attachment site motif mediates binding to integrins (ITGAV:ITGB6 or ITGAV:ITGB8). The motif locates to a long loop in the arm domain called the bowtie tail. Integrin-binding stabilizes an alternative conformation of the bowtie tail. Activation by integrin requires force application by the actin cytoskeleton, which is resisted by the 'milieu molecules' (such as LTBP1, LRRC32/GARP and/or LRRC33/NRROS), resulting in distortion of the prodomain and release of the active TGF-beta-1.|||Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.|||Transforming growth factor beta-1 proprotein: The precursor proprotein is cleaved in the Golgi apparatus by FURIN to form Transforming growth factor beta-1 (TGF-beta-1) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-1 inactive.|||extracellular matrix http://togogenome.org/gene/9940:SNX3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGU7|||http://purl.uniprot.org/uniprot/W5PMB1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome|||Endosome|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||phagosome http://togogenome.org/gene/9940:LOC101121590 ^@ http://purl.uniprot.org/uniprot/W5QGS6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCO1/2 family.|||Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.|||Homodimer.|||Mitochondrion inner membrane http://togogenome.org/gene/9940:VRK1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YRD5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9940:IL17A ^@ http://purl.uniprot.org/uniprot/W5PWW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9940:RPL37 ^@ http://purl.uniprot.org/uniprot/A0A6P3ELS3|||http://purl.uniprot.org/uniprot/W5P472 ^@ Caution|||Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRARG1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9T3|||http://purl.uniprot.org/uniprot/W5PMV3 ^@ Caution|||Similarity ^@ Belongs to the CD225/Dispanin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CPLX2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TQ93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9940:PAPPA2 ^@ http://purl.uniprot.org/uniprot/W5PZE1 ^@ Caution|||Similarity ^@ Belongs to the peptidase M43B family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:PRMT6 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5F5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EFNB3 ^@ http://purl.uniprot.org/uniprot/A0A6P3ED61|||http://purl.uniprot.org/uniprot/W5Q2X9 ^@ Caution|||Similarity ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZNF445 ^@ http://purl.uniprot.org/uniprot/A0A6P3TDT5|||http://purl.uniprot.org/uniprot/A0A6P7D5K4 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CBLIF ^@ http://purl.uniprot.org/uniprot/W5PRU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9940:HNRNPK ^@ http://purl.uniprot.org/uniprot/A0A6P3E105|||http://purl.uniprot.org/uniprot/W5Q2G6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm|||podosome http://togogenome.org/gene/9940:LOC101107125 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFM0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PGLS ^@ http://purl.uniprot.org/uniprot/A0A6P3E5F6|||http://purl.uniprot.org/uniprot/W5Q4B6 ^@ Caution|||Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.|||Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CGA ^@ http://purl.uniprot.org/uniprot/A0A836CZH3|||http://purl.uniprot.org/uniprot/P01218 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin (By similarity). The alpha chain can also be formed by LH alpha 1-1, LH alpha 1-2 and LH alpha 1-3.|||Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.|||Secreted|||Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101118549 ^@ http://purl.uniprot.org/uniprot/W5PAP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.|||Belongs to the RAP1 family.|||Homodimer.|||Nucleus|||telomere http://togogenome.org/gene/9940:RMDN3 ^@ http://purl.uniprot.org/uniprot/A0A6P7EA82 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:USP37 ^@ http://purl.uniprot.org/uniprot/W5QEA5 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9940:LOC101109919 ^@ http://purl.uniprot.org/uniprot/A0A836CVN3|||http://purl.uniprot.org/uniprot/W5QGB5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STX18 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAK7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Endoplasmic reticulum membrane|||Membrane|||Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101104356 ^@ http://purl.uniprot.org/uniprot/W5Q1D3 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:LOC101102091 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE39|||http://purl.uniprot.org/uniprot/W5Q6X8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101120084 ^@ http://purl.uniprot.org/uniprot/A0A836AFS8|||http://purl.uniprot.org/uniprot/W5PJL5 ^@ Caution|||Similarity ^@ Belongs to the sulfotransferase 1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STOML2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E181|||http://purl.uniprot.org/uniprot/W5PRD7 ^@ Caution|||Similarity ^@ Belongs to the band 7/mec-2 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RNF168 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6U0|||http://purl.uniprot.org/uniprot/W5QGI9 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ According to a well-established model, RNF168 cannot initiate H2A 'Lys-63'-linked ubiquitination and is recruited following RNF8-dependent histone ubiquitination to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.|||Belongs to the RNF168 family.|||E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).|||Monomer. Interacts with UBE2N/UBC13.|||Nucleus|||Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs).|||The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Ubiquitinated. http://togogenome.org/gene/9940:FAM162A ^@ http://purl.uniprot.org/uniprot/A0A6P3E078|||http://purl.uniprot.org/uniprot/W5QFW8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0389 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TYMS ^@ http://purl.uniprot.org/uniprot/W5PHY4 ^@ Similarity ^@ Belongs to the thymidylate synthase family. http://togogenome.org/gene/9940:ANAPC10 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDU2 ^@ Function|||Similarity ^@ Belongs to the APC10 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/9940:SLC14A1 ^@ http://purl.uniprot.org/uniprot/C5MK33|||http://purl.uniprot.org/uniprot/W5NWJ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Basolateral cell membrane|||Belongs to the urea transporter family.|||Cell membrane|||Homotrimer; each subunit contains a pore through which urea permeates (By similarity). Identified in a complex with STOM (By similarity).|||Mediates the transport of urea driven by a concentration gradient across the cell membranes of erythrocytes and the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (By similarity). Facilitates water transport in erythrocytes (By similarity).|||Membrane http://togogenome.org/gene/9940:LMNB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4M2|||http://purl.uniprot.org/uniprot/W5Q9T3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||Nucleus lamina|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SPACA3 ^@ http://purl.uniprot.org/uniprot/D7R6C8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 22 family.|||Interacts with ASTL.|||Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro. http://togogenome.org/gene/9940:ITGB1BP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EN08 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLIC4 ^@ http://purl.uniprot.org/uniprot/A0A6P3E1Y6|||http://purl.uniprot.org/uniprot/W5P8X9 ^@ Caution|||Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101108600 ^@ http://purl.uniprot.org/uniprot/A0A6P3YLS6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AKR1A1 ^@ http://purl.uniprot.org/uniprot/W5NUN8 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the aldo/keto reductase family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9940:ARSA ^@ http://purl.uniprot.org/uniprot/A0A6P3E8H2 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9940:DYNC1I1 ^@ http://purl.uniprot.org/uniprot/W5P0S4 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/9940:KHDC4 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7A3 ^@ Caution|||Similarity ^@ Belongs to the KHDC4 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPT1 ^@ http://purl.uniprot.org/uniprot/A0A836AF59 ^@ Caution|||Similarity ^@ Belongs to the palmitoyl-protein thioesterase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FBXL12 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9A0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RNASEK ^@ http://purl.uniprot.org/uniprot/A0A6P3EIF2|||http://purl.uniprot.org/uniprot/W5PIA0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase K family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101115064 ^@ http://purl.uniprot.org/uniprot/W5PAG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:KCNJ12 ^@ http://purl.uniprot.org/uniprot/A0A6P3EH92|||http://purl.uniprot.org/uniprot/A0A6P7EH40 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101109271 ^@ http://purl.uniprot.org/uniprot/A0A836A326 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:WASF2 ^@ http://purl.uniprot.org/uniprot/W5NZP8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9940:IL4 ^@ http://purl.uniprot.org/uniprot/P30368 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-4/IL-13 family.|||Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.|||Secreted http://togogenome.org/gene/9940:P3H2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YH39 ^@ Caution|||Similarity ^@ Belongs to the leprecan family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EMC6 ^@ http://purl.uniprot.org/uniprot/A0A6P3EH13|||http://purl.uniprot.org/uniprot/W5P280 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC6 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UGT1A9 ^@ http://purl.uniprot.org/uniprot/Q9XS56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9940:POGLUT2 ^@ http://purl.uniprot.org/uniprot/W5P5B4 ^@ Similarity ^@ Belongs to the KDELC family. http://togogenome.org/gene/9940:GPR15 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7R3 ^@ Caution|||Similarity ^@ Belongs to the G-protein coupled receptor 1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STX17 ^@ http://purl.uniprot.org/uniprot/W5PMN4 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9940:UCN ^@ http://purl.uniprot.org/uniprot/W5QDZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/9940:CD1 ^@ http://purl.uniprot.org/uniprot/Q28565 ^@ Function|||Miscellaneous|||Subcellular Location Annotation|||Subunit ^@ Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.|||Cell membrane|||During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface. Interaction with saposin C is required for the loading of bacterial lipid antigens onto CD1B in the lysosome (By similarity).|||Endosome membrane|||Heterodimer with B2M (beta-2-microglobulin). Interacts with saposin C (By similarity).|||Lysosome membrane http://togogenome.org/gene/9940:XRN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7N0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NUDCD3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E516 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101115538 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEJ5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ECSIT ^@ http://purl.uniprot.org/uniprot/W5QB33 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development.|||As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the ECSIT family.|||Cytoplasm|||Mitochondrion|||Nucleus http://togogenome.org/gene/9940:RACK1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQX8|||http://purl.uniprot.org/uniprot/S4TZR5 ^@ Caution|||Similarity ^@ Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KRT71 ^@ http://purl.uniprot.org/uniprot/A0A6P3CY35|||http://purl.uniprot.org/uniprot/G3ER51 ^@ Caution|||Similarity ^@ Belongs to the intermediate filament family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DTD2 ^@ http://purl.uniprot.org/uniprot/W5P8M0 ^@ Similarity ^@ Belongs to the DTD family. http://togogenome.org/gene/9940:LOC101120675 ^@ http://purl.uniprot.org/uniprot/W5P260 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:PHC3 ^@ http://purl.uniprot.org/uniprot/W5NQI9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:PIK3IP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YNG6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:CTNNA1 ^@ http://purl.uniprot.org/uniprot/A0A6P7E7A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction|||cytoskeleton http://togogenome.org/gene/9940:ELF4 ^@ http://purl.uniprot.org/uniprot/A0A6P3T7K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9940:TRIM33 ^@ http://purl.uniprot.org/uniprot/A0A6P3DYS0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IZUMO3 ^@ http://purl.uniprot.org/uniprot/W5PYL2 ^@ Similarity ^@ Belongs to the Izumo family. http://togogenome.org/gene/9940:LOC101110777 ^@ http://purl.uniprot.org/uniprot/A0A6P3TWI2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAIM2 ^@ http://purl.uniprot.org/uniprot/W5Q9X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9940:SHROOM1 ^@ http://purl.uniprot.org/uniprot/W5PUJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/9940:B3GAT3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDA0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLN5 ^@ http://purl.uniprot.org/uniprot/A2TJ54 ^@ Disease Annotation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CLN5 family.|||Can undergo proteolytic cleavage at the C-terminus, probably by a cysteine protease and may involve the removal of approximately 10-15 residues from the C-terminal end.|||Defects in CLN5 are the cause of neuronal ceroid lipofuscinosis (NCL). NCL is characterized by brain atrophy and the accumulation of lysosome derived fluorescent storage bodies in neurons and most other cells. NCL is found in New Zealand Borderdale sheep.|||Interacts with SORT1, RAB5A and RAB7A. Interacts with PPT1, TPP1, CLN3, CLN6, CLN8, ATP5F1A and ATP5F1B.|||Lysosome|||Membrane|||N-glycosylated with both high mannose and complex type sugars. Glycosylation is important for proper folding and trafficking to the lysosomes.|||Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.|||The type II membrane signal anchor is proteolytically cleaved to produce a mature form that is transported to the lysosomes (Ceroid-lipofuscinosis neuronal protein 5, secreted form). http://togogenome.org/gene/9940:FAM216B ^@ http://purl.uniprot.org/uniprot/W5PBZ4 ^@ Similarity ^@ Belongs to the FAM216 family. http://togogenome.org/gene/9940:TP53RK ^@ http://purl.uniprot.org/uniprot/A0A6P3EC06|||http://purl.uniprot.org/uniprot/W5PHA6 ^@ Caution|||Similarity ^@ Belongs to the protein kinase superfamily. BUD32 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SOX2 ^@ http://purl.uniprot.org/uniprot/A0A0N9XTU0|||http://purl.uniprot.org/uniprot/A0A836D8U9|||http://purl.uniprot.org/uniprot/P54231 ^@ Caution|||Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Interacts with ZSCAN10 (By similarity). Interacts with SOX3 and FGFR1 (By similarity). Interacts with GLIS1 (By similarity). Interacts with POU5F1; binds synergistically with POU5F1 to DNA (By similarity). Interacts with DDX56 (By similarity).|||Nucleus|||Sumoylation inhibits DNA binding and negatively regulates the FGF4 transactivation.|||The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity). http://togogenome.org/gene/9940:SLC28A3 ^@ http://purl.uniprot.org/uniprot/W5PGL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/9940:FRK ^@ http://purl.uniprot.org/uniprot/W5PI49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9940:EBF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TSP4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STK32A ^@ http://purl.uniprot.org/uniprot/W5NZQ3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9940:PCOLCE ^@ http://purl.uniprot.org/uniprot/W5Q517 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9940:LOC101108251 ^@ http://purl.uniprot.org/uniprot/W5P8D0 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:C3AR1 ^@ http://purl.uniprot.org/uniprot/W5QGJ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with VGF-derived peptide TLQP-21.|||Membrane|||Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. http://togogenome.org/gene/9940:CTTNBP2 ^@ http://purl.uniprot.org/uniprot/Q09YI1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.|||Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.|||cell cortex|||dendritic spine http://togogenome.org/gene/9940:IGFBP1 ^@ http://purl.uniprot.org/uniprot/B9VQ08 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds equally well IGF1 and IGF2.|||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9940:C3H12orf4 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8C3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATP6V1G2 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENV2|||http://purl.uniprot.org/uniprot/W5PG22 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9940:CYB5A ^@ http://purl.uniprot.org/uniprot/A0A6P9FQQ0|||http://purl.uniprot.org/uniprot/C9E8M7 ^@ Caution|||Similarity ^@ Belongs to the cytochrome b5 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM19 ^@ http://purl.uniprot.org/uniprot/W5PZ01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/9940:EBI3 ^@ http://purl.uniprot.org/uniprot/A0A836A609 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SFXN5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E2R0|||http://purl.uniprot.org/uniprot/W5PPW8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane|||Mitochondrion membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FGF1 ^@ http://purl.uniprot.org/uniprot/A0A836A6A4|||http://purl.uniprot.org/uniprot/Q7M303 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heparin-binding growth factors family.|||Cytoplasm|||In the nucleus, phosphorylated by PKC/PRKCD.|||Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13 (By similarity). Interacts with LRRC59 (By similarity). Interacts with CSNKA, CSNKB and FIBP (By similarity). While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1. Forms a ternary complex with FGFR1 and ITGAV:ITGB3 and induces the recruitment of PTPN11 to the complex (By similarity).|||Nucleus|||Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis.|||Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cell cortex|||cytosol http://togogenome.org/gene/9940:FGF7 ^@ http://purl.uniprot.org/uniprot/A0A6P3TF60|||http://purl.uniprot.org/uniprot/B2MVW3|||http://purl.uniprot.org/uniprot/W5QIL6 ^@ Caution|||Similarity ^@ Belongs to the heparin-binding growth factors family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLCC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3DYM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel MCLC family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/9940:KYNU ^@ http://purl.uniprot.org/uniprot/A0A6P3E1G7|||http://purl.uniprot.org/uniprot/W5PJN6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAM210A ^@ http://purl.uniprot.org/uniprot/A0A6P3ER97|||http://purl.uniprot.org/uniprot/A0A6P3TJF4 ^@ Caution|||Similarity ^@ Belongs to the FAM210 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ETS1 ^@ http://purl.uniprot.org/uniprot/W5PUA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9940:SLC51B ^@ http://purl.uniprot.org/uniprot/A0A6P3EFH0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101121706 ^@ http://purl.uniprot.org/uniprot/W5PAP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:SNCG ^@ http://purl.uniprot.org/uniprot/A0A6P3ES45 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the synuclein family.|||May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRPS27 ^@ http://purl.uniprot.org/uniprot/W5P4Z8 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9940:LPGAT1 ^@ http://purl.uniprot.org/uniprot/W5PP09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9940:SASS6 ^@ http://purl.uniprot.org/uniprot/W5Q944 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/9940:LOC101122801 ^@ http://purl.uniprot.org/uniprot/W5PXK9 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9940:AKR1B1 ^@ http://purl.uniprot.org/uniprot/W5PC00 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9940:LIN28B ^@ http://purl.uniprot.org/uniprot/A0A411PNQ7|||http://purl.uniprot.org/uniprot/H6WP39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-28 family.|||nucleolus http://togogenome.org/gene/9940:MMP27 ^@ http://purl.uniprot.org/uniprot/W5P6G5 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9940:RITA1 ^@ http://purl.uniprot.org/uniprot/W5PFG3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RITA family.|||Cytoplasm|||Interacts with RBPJ/RBPSUH.|||Nucleus|||Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis. http://togogenome.org/gene/9940:TYW5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6G7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IFNT6 ^@ http://purl.uniprot.org/uniprot/A0A836ALP8|||http://purl.uniprot.org/uniprot/Q29429 ^@ Caution|||Developmental Stage|||Function|||Miscellaneous|||Polymorphism|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.|||Constitutively and exclusively expressed in the mononuclear cells of the extraembryonic trophectoderm.|||IFN-tau genes are intronless. They evolved from IFN-omega genes in the ruminantia suborder and have continued to duplicate independently in different lineages of the ruminantia. They code for proteins very similar in sequence but with different biological potency and pattern of expression.|||Major secretory product synthesized by the sheep conceptus between days 13 and 21 of pregnancy.|||Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||There seems to be four variants of IFN-tau 6: A/p6V3, B/p6V2, C/p6V1 and D/P6/p12 (shown here). http://togogenome.org/gene/9940:MRPS14 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJU2|||http://purl.uniprot.org/uniprot/W5PWH1 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uS14 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PGRMC1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FRJ1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NDUFC2 ^@ http://purl.uniprot.org/uniprot/A0A6P3ED46 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFC2 subunit family.|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NADK ^@ http://purl.uniprot.org/uniprot/W5NVE9 ^@ Similarity ^@ Belongs to the NAD kinase family. http://togogenome.org/gene/9940:NUDT21 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFC9|||http://purl.uniprot.org/uniprot/W5QAS3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. CPSF5 subfamily.|||Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.|||Cytoplasm|||Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CAPNS1 ^@ http://purl.uniprot.org/uniprot/W5P5G5 ^@ Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Cytoplasm|||Homodimer or heterodimer of a large (catalytic) and a small (regulatory) subunit. In presence of calcium, the heterodimer dissociates.|||Membrane http://togogenome.org/gene/9940:TYROBP ^@ http://purl.uniprot.org/uniprot/A0A6P3ELB0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TYROBP family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101110824 ^@ http://purl.uniprot.org/uniprot/A0A6P3TLP1 ^@ Caution|||Similarity ^@ Belongs to the cystatin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TNFRSF1A ^@ http://purl.uniprot.org/uniprot/C8BKB9 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9940:ANGPT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGD4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101109111 ^@ http://purl.uniprot.org/uniprot/W5PN69 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9940:SCUBE2 ^@ http://purl.uniprot.org/uniprot/W5PVQ7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9940:ELAVL1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm http://togogenome.org/gene/9940:TPX2 ^@ http://purl.uniprot.org/uniprot/A0A6P7ENX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TPX2 family.|||Nucleus|||spindle pole http://togogenome.org/gene/9940:MINAR1 ^@ http://purl.uniprot.org/uniprot/W5Q0B9 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/9940:ST3GAL5 ^@ http://purl.uniprot.org/uniprot/S5M610 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9940:TAS1R1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8X9|||http://purl.uniprot.org/uniprot/W5PPL9 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101107047 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE05 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCDC181 ^@ http://purl.uniprot.org/uniprot/A0A6P3TXM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC181 family.|||Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.|||cytoskeleton|||flagellum http://togogenome.org/gene/9940:ADRA1A ^@ http://purl.uniprot.org/uniprot/A0A6P3E7Y7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||Nucleus membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||caveola http://togogenome.org/gene/9940:LOC101113524 ^@ http://purl.uniprot.org/uniprot/A0A6P3ELT2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PTBP3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YHE2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RIOK2 ^@ http://purl.uniprot.org/uniprot/W5Q9S9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/9940:EPCAM ^@ http://purl.uniprot.org/uniprot/C5ISB0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPCAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.|||Membrane|||tight junction http://togogenome.org/gene/9940:LOC101112029 ^@ http://purl.uniprot.org/uniprot/A0A6P3EMY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9940:CEP41 ^@ http://purl.uniprot.org/uniprot/A0A836AAH6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PSME1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEM0|||http://purl.uniprot.org/uniprot/W5QD49 ^@ Caution|||Similarity ^@ Belongs to the PA28 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FGB ^@ http://purl.uniprot.org/uniprot/A0A836CUX2|||http://purl.uniprot.org/uniprot/W5NQ46 ^@ Caution|||Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HARS1 ^@ http://purl.uniprot.org/uniprot/W5QAU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/9940:PPEF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3THC6 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/9940:SRP72 ^@ http://purl.uniprot.org/uniprot/W5P2J3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP72 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).|||Cytoplasm http://togogenome.org/gene/9940:S100A13 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFJ7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLP1 ^@ http://purl.uniprot.org/uniprot/W5NQW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9940:LOC101104933 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAU3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ACE2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TFC0 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the peptidase M2 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Membrane|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cilium http://togogenome.org/gene/9940:DCTN5 ^@ http://purl.uniprot.org/uniprot/A0A6P3ELL2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PSMB4 ^@ http://purl.uniprot.org/uniprot/W5QIL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/9940:MMAA ^@ http://purl.uniprot.org/uniprot/A0A6P3EBB5 ^@ Caution|||Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C1H1orf43 ^@ http://purl.uniprot.org/uniprot/A0A836D6Z9|||http://purl.uniprot.org/uniprot/W5NVE4 ^@ Caution|||Function|||Subcellular Location Annotation ^@ General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.|||Golgi apparatus|||Membrane|||Mitochondrion|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NAA60 ^@ http://purl.uniprot.org/uniprot/A0A6P3T5N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA60 subfamily.|||Golgi apparatus membrane http://togogenome.org/gene/9940:VAMP4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE46|||http://purl.uniprot.org/uniprot/W5PW08 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NEFM ^@ http://purl.uniprot.org/uniprot/W5PJQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||axon|||cytoskeleton http://togogenome.org/gene/9940:CALR ^@ http://purl.uniprot.org/uniprot/A0A6P3E5I0|||http://purl.uniprot.org/uniprot/A0A6P7E595 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calreticulin family.|||Endoplasmic reticulum lumen|||Monomer.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GTF2A2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EF18|||http://purl.uniprot.org/uniprot/A0A6P7DBL1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC38A9 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDN5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101119629 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3J1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:F8 ^@ http://purl.uniprot.org/uniprot/D3IU20 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9940:MRPS22 ^@ http://purl.uniprot.org/uniprot/A0A6P3E0H4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101107221 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAU9|||http://purl.uniprot.org/uniprot/W5PC30 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPL31 ^@ http://purl.uniprot.org/uniprot/W5PUU0 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9940:SERPINE1 ^@ http://purl.uniprot.org/uniprot/D4N532 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9940:SMIM3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9R8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IL33 ^@ http://purl.uniprot.org/uniprot/A0A836D8X1|||http://purl.uniprot.org/uniprot/W5PVY1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family. Highly divergent.|||Chromosome|||Nucleus|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Vesicle|||secretory vesicle http://togogenome.org/gene/9940:ACKR4 ^@ http://purl.uniprot.org/uniprot/A0A6P7DC27 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9940:LOC101110394 ^@ http://purl.uniprot.org/uniprot/A0A836ANA0|||http://purl.uniprot.org/uniprot/W5QAB9 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with UHRF2/NIRF.|||May be involved in cell cycle regulation.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RNF26 ^@ http://purl.uniprot.org/uniprot/A0A6P3EK95 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101104500 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBW0|||http://purl.uniprot.org/uniprot/W5NWY6 ^@ Caution|||Similarity ^@ Belongs to the G-protein coupled receptor 1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IL2RG ^@ http://purl.uniprot.org/uniprot/A0A835ZKE8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZNF518B ^@ http://purl.uniprot.org/uniprot/A0A6P3YJU6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRPT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TD21 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate. http://togogenome.org/gene/9940:SBD2 ^@ http://purl.uniprot.org/uniprot/E2ITD7 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9940:POLH ^@ http://purl.uniprot.org/uniprot/W5PD86 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:NKX3-1 ^@ http://purl.uniprot.org/uniprot/W5PK28 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:CASP8 ^@ http://purl.uniprot.org/uniprot/A0A6P3T9A7|||http://purl.uniprot.org/uniprot/A0A6P3TJN8 ^@ Caution|||Similarity ^@ Belongs to the peptidase C14A family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC7A11 ^@ http://purl.uniprot.org/uniprot/A0A6P3TA75|||http://purl.uniprot.org/uniprot/G3FHC4|||http://purl.uniprot.org/uniprot/H2EUS8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPL36AL ^@ http://purl.uniprot.org/uniprot/A0A6P3EEZ5|||http://purl.uniprot.org/uniprot/W5NRQ6 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CATSPERZ ^@ http://purl.uniprot.org/uniprot/A0A835ZUG8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KRT35 ^@ http://purl.uniprot.org/uniprot/B0LKP1 ^@ Miscellaneous|||Similarity ^@ Belongs to the intermediate filament family.|||There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic). http://togogenome.org/gene/9940:FARSA ^@ http://purl.uniprot.org/uniprot/W5PJU6 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. http://togogenome.org/gene/9940:SMIM20 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5E5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HIGD1A ^@ http://purl.uniprot.org/uniprot/A0A835ZMU2|||http://purl.uniprot.org/uniprot/W5Q7R3 ^@ Caution|||Subcellular Location Annotation ^@ Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FGF5 ^@ http://purl.uniprot.org/uniprot/I6WYL7|||http://purl.uniprot.org/uniprot/I6XXC7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heparin-binding growth factors family.|||Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.|||Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.|||Secreted http://togogenome.org/gene/9940:LOC101106976 ^@ http://purl.uniprot.org/uniprot/A0A836CS49 ^@ Caution|||Similarity ^@ Belongs to the GST superfamily. Alpha family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CNOT6L ^@ http://purl.uniprot.org/uniprot/A0A6P3EE53|||http://purl.uniprot.org/uniprot/A0A6P3YM05 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCR4/nocturin family.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ADGRG7 ^@ http://purl.uniprot.org/uniprot/A0A836AHB3|||http://purl.uniprot.org/uniprot/W5Q9J5 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101108520 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBX9|||http://purl.uniprot.org/uniprot/A0A6P3T2M4 ^@ Caution|||Similarity ^@ Belongs to the ATP:guanido phosphotransferase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101121048 ^@ http://purl.uniprot.org/uniprot/A0A835ZQD8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101116371 ^@ http://purl.uniprot.org/uniprot/W5NRV6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9940:LOC101119808 ^@ http://purl.uniprot.org/uniprot/A0A836D814|||http://purl.uniprot.org/uniprot/W5QA96 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BRPF1 ^@ http://purl.uniprot.org/uniprot/W5P8K3|||http://purl.uniprot.org/uniprot/W5P8K6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:PTAR1 ^@ http://purl.uniprot.org/uniprot/A0A836AAB2 ^@ Caution|||Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RAB39B ^@ http://purl.uniprot.org/uniprot/A0A6P3EN47 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C2H9orf64 ^@ http://purl.uniprot.org/uniprot/W5PGP8 ^@ Function|||Similarity ^@ Belongs to the queuosine salvage protein family.|||Involved in salvaging queuosine. http://togogenome.org/gene/9940:LOC101109989 ^@ http://purl.uniprot.org/uniprot/A0A6P3TY83 ^@ Similarity ^@ Belongs to the SELO family. http://togogenome.org/gene/9940:CAPZA1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E497|||http://purl.uniprot.org/uniprot/W5Q694 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC105601854 ^@ http://purl.uniprot.org/uniprot/W5PI50 ^@ Function ^@ Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. http://togogenome.org/gene/9940:KCNC1 ^@ http://purl.uniprot.org/uniprot/W5NUC4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:RPS3 ^@ http://purl.uniprot.org/uniprot/A0A836A242 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Membrane|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus|||spindle http://togogenome.org/gene/9940:CS ^@ http://purl.uniprot.org/uniprot/A0A6P3E7X6|||http://purl.uniprot.org/uniprot/W5PI34 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the citrate synthase family.|||Homodimer.|||Mitochondrion matrix|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:B9D2 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECE6|||http://purl.uniprot.org/uniprot/A0A6P3TZF3 ^@ Caution|||Subcellular Location Annotation ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cilium basal body http://togogenome.org/gene/9940:MFSD14B ^@ http://purl.uniprot.org/uniprot/W5Q1Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9940:ZNF202 ^@ http://purl.uniprot.org/uniprot/W5NRJ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:LOC101116903 ^@ http://purl.uniprot.org/uniprot/W5NT83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:MFAP3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YLZ1 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SPDL1 ^@ http://purl.uniprot.org/uniprot/W5NY23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Spindly family.|||Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.|||Nucleus|||Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.|||centrosome|||kinetochore|||spindle pole http://togogenome.org/gene/9940:FABP3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TBK2|||http://purl.uniprot.org/uniprot/I1ZAM7|||http://purl.uniprot.org/uniprot/W5NU39 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101118250 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHI3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101116001 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3Z5|||http://purl.uniprot.org/uniprot/W5P697 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hcp beta-lactamase family.|||Mitochondrion intermembrane space|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CD200 ^@ http://purl.uniprot.org/uniprot/W5QDD1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9940:S100G ^@ http://purl.uniprot.org/uniprot/W5PU09 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9940:CIAPIN1 ^@ http://purl.uniprot.org/uniprot/A0A836A1G0|||http://purl.uniprot.org/uniprot/W5NPU7 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion intermembrane space|||Monomer. Interacts with NDOR1. Interacts with CHCHD4.|||Nucleus|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/9940:NKIRAS2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TL64|||http://purl.uniprot.org/uniprot/W5QA55 ^@ Caution|||Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GNG11 ^@ http://purl.uniprot.org/uniprot/B6V716 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9940:KLK6 ^@ http://purl.uniprot.org/uniprot/A0A6P3TNN4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101123619 ^@ http://purl.uniprot.org/uniprot/W5Q4I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family.|||Nucleus http://togogenome.org/gene/9940:CDKN3 ^@ http://purl.uniprot.org/uniprot/A0A836D0G5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family.|||May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||perinuclear region http://togogenome.org/gene/9940:IL17RB ^@ http://purl.uniprot.org/uniprot/A0A6P3EN68|||http://purl.uniprot.org/uniprot/W5Q2V7 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NFIL3 ^@ http://purl.uniprot.org/uniprot/A0A6P3CX68|||http://purl.uniprot.org/uniprot/B7SH79 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death.|||Belongs to the bZIP family. NFIL3 subfamily.|||Homodimer. Binds DNA as a dimer.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101109676 ^@ http://purl.uniprot.org/uniprot/A0A835ZJ51|||http://purl.uniprot.org/uniprot/K4P217 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL22 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SDHAF2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQI9|||http://purl.uniprot.org/uniprot/W5PU49 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SDHAF2 family.|||Interacts with SDHA within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRPF4B ^@ http://purl.uniprot.org/uniprot/W5NQX9 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.|||Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. http://togogenome.org/gene/9940:SUSD3 ^@ http://purl.uniprot.org/uniprot/W5PE64 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:SLC5A1 ^@ http://purl.uniprot.org/uniprot/A0A835ZR40|||http://purl.uniprot.org/uniprot/P53791 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (By similarity). Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis (By similarity). Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules (By similarity). Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception (By similarity). Acts as a water channel enabling passive water transport in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity comparable to aquaporins and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine.|||Membrane|||N-glycosylation is not necessary for the cotransporter function.|||The cholesterol-binding site is formed by transmembrane helices TM1, TM7 and TM13.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PI4K2B ^@ http://purl.uniprot.org/uniprot/A0A6P3EAA7|||http://purl.uniprot.org/uniprot/W5P9Q0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SIVA1 ^@ http://purl.uniprot.org/uniprot/W5PD20 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.|||Nucleus http://togogenome.org/gene/9940:SLC17A6 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQC9 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LARS2 ^@ http://purl.uniprot.org/uniprot/W5PLQ3 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9940:MS4A2 ^@ http://purl.uniprot.org/uniprot/W5PT67 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9940:DCTD ^@ http://purl.uniprot.org/uniprot/A0A6P7DI23 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/9940:SELENBP1 ^@ http://purl.uniprot.org/uniprot/W5QIK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the selenium-binding protein family.|||Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.|||Interacts with USP33.|||Membrane|||Nucleus|||cytosol http://togogenome.org/gene/9940:PTH2R ^@ http://purl.uniprot.org/uniprot/W5QCN9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:LYPD2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TJS8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PIGY ^@ http://purl.uniprot.org/uniprot/A0A6P3TT84 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CPSF3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAP9|||http://purl.uniprot.org/uniprot/W5Q0D9 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ACTA1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ERW2|||http://purl.uniprot.org/uniprot/W5NYJ1 ^@ Caution|||Similarity ^@ Belongs to the actin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DESI1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E424 ^@ Caution|||Similarity ^@ Belongs to the DeSI family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMPRSS13 ^@ http://purl.uniprot.org/uniprot/W5PBU4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:PRICKLE1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TEM6 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9940:RASSF3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E383 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RCVRN ^@ http://purl.uniprot.org/uniprot/A0A6P3YL56 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101122163 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGX8|||http://purl.uniprot.org/uniprot/A0A6P7ER11 ^@ Caution|||Similarity ^@ Belongs to the UPF0547 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC2A3 ^@ http://purl.uniprot.org/uniprot/A0A836D4Q1|||http://purl.uniprot.org/uniprot/P47843 ^@ Activity Regulation|||Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Cell projection|||Deoxyglucose transport is inhibit by D-glucose, D-galactose and maltose. Galactose transport is inhibited by D-glucose and maltose.|||Detected in placenta.|||Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Perikaryon|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm. http://togogenome.org/gene/9940:PEX5 ^@ http://purl.uniprot.org/uniprot/A0A836D8B1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal targeting signal receptor family.|||Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.|||Cytoplasm|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DDX58 ^@ http://purl.uniprot.org/uniprot/W5PZB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9940:IRAK1BP1 ^@ http://purl.uniprot.org/uniprot/W5PA12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRAK1BP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9940:PNN ^@ http://purl.uniprot.org/uniprot/W5PFN0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pinin family.|||Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.|||Nucleus speckle|||desmosome http://togogenome.org/gene/9940:FAF2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4N2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IL5 ^@ http://purl.uniprot.org/uniprot/Q28586 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-5 family.|||Homodimer; disulfide-linked. Interacts with IL5RA. Interacts with CSF2RB.|||Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (By similarity).|||Secreted http://togogenome.org/gene/9940:FAM78B ^@ http://purl.uniprot.org/uniprot/A0A6P3DZA6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SERPINF1 ^@ http://purl.uniprot.org/uniprot/B6UV62 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9940:C4H7orf57 ^@ http://purl.uniprot.org/uniprot/A0A836D2E8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EIF5 ^@ http://purl.uniprot.org/uniprot/W5P6I6 ^@ Function|||Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). http://togogenome.org/gene/9940:DGKG ^@ http://purl.uniprot.org/uniprot/A0A6P3E6W2|||http://purl.uniprot.org/uniprot/W5QH74 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:METTL15 ^@ http://purl.uniprot.org/uniprot/A0A6P7EYQ5 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. RsmH family. http://togogenome.org/gene/9940:DHTKD1 ^@ http://purl.uniprot.org/uniprot/W5PZN4 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/9940:SIX6 ^@ http://purl.uniprot.org/uniprot/A0A6P3CXG3|||http://purl.uniprot.org/uniprot/C5HK63 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SIX/Sine oculis homeobox family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TWSG1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YPU1|||http://purl.uniprot.org/uniprot/W5NSD4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the twisted gastrulation protein family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NLGN3 ^@ http://purl.uniprot.org/uniprot/A0A6P3ESH8|||http://purl.uniprot.org/uniprot/W5Q544 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PFDN1 ^@ http://purl.uniprot.org/uniprot/W5Q7Q9 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/9940:CCNG1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TRS3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin G subfamily.|||May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.|||Nucleus http://togogenome.org/gene/9940:RPS23 ^@ http://purl.uniprot.org/uniprot/A0A836ADF7 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Component of the 40S small ribosomal subunit.|||Rough endoplasmic reticulum|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101103739 ^@ http://purl.uniprot.org/uniprot/A0A835ZW32 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101115661 ^@ http://purl.uniprot.org/uniprot/A0A6P3YS37 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MARCHF7 ^@ http://purl.uniprot.org/uniprot/A0A6P3E1E5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLDND1 ^@ http://purl.uniprot.org/uniprot/A0A836AQL4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LRRC8A ^@ http://purl.uniprot.org/uniprot/A0A6P3E215|||http://purl.uniprot.org/uniprot/A0A6P3TA94 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC106991540 ^@ http://purl.uniprot.org/uniprot/W5QF62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:TMEM254 ^@ http://purl.uniprot.org/uniprot/A0A6P3EMD2 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PDP2 ^@ http://purl.uniprot.org/uniprot/W5PN71 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9940:LOC101119531 ^@ http://purl.uniprot.org/uniprot/A0A836D4T2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FBXO22 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE90 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IYD ^@ http://purl.uniprot.org/uniprot/A0A836A286 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Cytoplasmic vesicle membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CD53 ^@ http://purl.uniprot.org/uniprot/M4WHJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9940:ZNF280C ^@ http://purl.uniprot.org/uniprot/A0A6P3YUF6 ^@ Function|||Subcellular Location Annotation ^@ May function as a transcription factor.|||Nucleus http://togogenome.org/gene/9940:ATP6V1FNB ^@ http://purl.uniprot.org/uniprot/A0A6P3TLF4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ILVBL ^@ http://purl.uniprot.org/uniprot/A0A6P3E4G0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TPP enzyme family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TGFB2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8J6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||extracellular matrix http://togogenome.org/gene/9940:CRY2 ^@ http://purl.uniprot.org/uniprot/A0A6P3CX27|||http://purl.uniprot.org/uniprot/A0A6P7ETI3 ^@ Caution|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101108922 ^@ http://purl.uniprot.org/uniprot/A0A836A327 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FN3K ^@ http://purl.uniprot.org/uniprot/A0A6P3E895|||http://purl.uniprot.org/uniprot/W5Q3U8 ^@ Caution|||Similarity ^@ Belongs to the fructosamine kinase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SAMD4B ^@ http://purl.uniprot.org/uniprot/A0A6P3YMJ9|||http://purl.uniprot.org/uniprot/W5P7R9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SMAUG family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCDC169 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFG8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TP53INP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YJI5 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/9940:NFIB ^@ http://purl.uniprot.org/uniprot/H9CJU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CTF/NF-I family.|||Nucleus http://togogenome.org/gene/9940:IL16 ^@ http://purl.uniprot.org/uniprot/W5Q2G2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Homotetramer.|||Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.|||Nucleus|||Secreted http://togogenome.org/gene/9940:GOLGA7 ^@ http://purl.uniprot.org/uniprot/A0A835ZJP0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RIPPLY3 ^@ http://purl.uniprot.org/uniprot/W5PXM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ripply family.|||Nucleus http://togogenome.org/gene/9940:AQP5 ^@ http://purl.uniprot.org/uniprot/Q866S3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).|||Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Forms a water-specific channel (By similarity). Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity).|||Homotetramer. Interacts with TRPV4; the interaction is probably indirect and regulates TRPV4 activation by hypotonicity. http://togogenome.org/gene/9940:UBE2H ^@ http://purl.uniprot.org/uniprot/W5P3W3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9940:FBN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TFV4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fibrillin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||extracellular matrix http://togogenome.org/gene/9940:DPP8 ^@ http://purl.uniprot.org/uniprot/A0A836AB87 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC5A6 ^@ http://purl.uniprot.org/uniprot/W5QD13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9940:ROGDI ^@ http://purl.uniprot.org/uniprot/A0A6P3ELG6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the rogdi family.|||Perikaryon|||Presynapse|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||synaptic vesicle http://togogenome.org/gene/9940:RNASEH2A ^@ http://purl.uniprot.org/uniprot/A0A6P3TRY4|||http://purl.uniprot.org/uniprot/A0A6P7E2N3 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family. Eukaryotic subfamily.|||Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KCNK5 ^@ http://purl.uniprot.org/uniprot/W5Q4Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9940:GALR1 ^@ http://purl.uniprot.org/uniprot/W5P2L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9940:KIF20B ^@ http://purl.uniprot.org/uniprot/W5Q1Q1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9940:SPG21 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAP4|||http://purl.uniprot.org/uniprot/A0A6P3TNN2 ^@ Caution|||Function ^@ May play a role as a negative regulatory factor in CD4-dependent T-cell activation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TKT ^@ http://purl.uniprot.org/uniprot/A0A6P3EPF2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARF3 ^@ http://purl.uniprot.org/uniprot/C5IWU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9940:IL18 ^@ http://purl.uniprot.org/uniprot/Q9GL09 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||Cytoplasm|||Forms a ternary complex with ligand-binding receptor subunit IL18R1 and signaling receptor subunit IL18RAP at the plasma membrane. Mature IL18 first binds to IL18R1 forming a low affinity binary complex, which then interacts with IL18RAP to form a high affinity ternary complex that signals inside the cell. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.|||Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted http://togogenome.org/gene/9940:KRTAP1-1 ^@ http://purl.uniprot.org/uniprot/Q29619 ^@ Function ^@ The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa). http://togogenome.org/gene/9940:MAGEH1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ESD3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATP6V1E2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TKU3|||http://purl.uniprot.org/uniprot/A0A6P7DWN1 ^@ Caution|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101110445 ^@ http://purl.uniprot.org/uniprot/W5PUI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:C16H5orf22 ^@ http://purl.uniprot.org/uniprot/A0A836CXQ3|||http://purl.uniprot.org/uniprot/W5PSD9 ^@ Caution|||Similarity ^@ Belongs to the UPF0489 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BLOC1S1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TK39|||http://purl.uniprot.org/uniprot/W5PNW2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BLOC1S1 family.|||Lysosome membrane|||May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.|||Mitochondrion intermembrane space|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MTERF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TR21 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9940:EFNB2 ^@ http://purl.uniprot.org/uniprot/W5P5Z2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9940:WBP4 ^@ http://purl.uniprot.org/uniprot/W5PAD2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:LOC443313 ^@ http://purl.uniprot.org/uniprot/A0A6P9FNB2 ^@ Similarity ^@ Belongs to the cornifin (SPRR) family. http://togogenome.org/gene/9940:WFDC5 ^@ http://purl.uniprot.org/uniprot/A0A6P3EKS7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STAG3 ^@ http://purl.uniprot.org/uniprot/W5Q6Z7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/9940:SF3A3 ^@ http://purl.uniprot.org/uniprot/A0A6P3DYL3|||http://purl.uniprot.org/uniprot/W5QFB8 ^@ Caution|||Similarity ^@ Belongs to the SF3A3 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101103354 ^@ http://purl.uniprot.org/uniprot/A0A835ZNR0|||http://purl.uniprot.org/uniprot/W5PHB3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARL8A ^@ http://purl.uniprot.org/uniprot/A0A6P9FQK2|||http://purl.uniprot.org/uniprot/C5IWT8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Synapse|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||spindle http://togogenome.org/gene/9940:RCBTB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YJL0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRHR ^@ http://purl.uniprot.org/uniprot/A0A835ZYF4|||http://purl.uniprot.org/uniprot/Q28596 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DERL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC66 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TCTN2 ^@ http://purl.uniprot.org/uniprot/W5NY09 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/9940:HABP2 ^@ http://purl.uniprot.org/uniprot/W5PSM6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9940:CIB4 ^@ http://purl.uniprot.org/uniprot/C7A278 ^@ Miscellaneous|||Subunit|||Tissue Specificity ^@ Interacts with ITGA2B (via C-terminus cytoplasmic tail region); the interaction is stabilized/increased in a calcium- and magnesium-dependent manner.|||Isoform 1 and isoform 2 are expressed in testis.|||The binding of either calcium or magnesium may significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form). http://togogenome.org/gene/9940:TYRP1 ^@ http://purl.uniprot.org/uniprot/B3VKX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/9940:SUPT3H ^@ http://purl.uniprot.org/uniprot/A0A6P3YND7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:TGFBR1 ^@ http://purl.uniprot.org/uniprot/W5PMT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9940:KCNK6 ^@ http://purl.uniprot.org/uniprot/W5P6C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9940:ADGRL4 ^@ http://purl.uniprot.org/uniprot/A0A6P3DYZ2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC16A3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TLB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9940:AP1S2 ^@ http://purl.uniprot.org/uniprot/W5PTE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||clathrin-coated pit http://togogenome.org/gene/9940:MAPRE1 ^@ http://purl.uniprot.org/uniprot/A0A6P7END3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||centrosome|||spindle pole http://togogenome.org/gene/9940:VBP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EF65|||http://purl.uniprot.org/uniprot/W5P0G8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E0D1 ^@ Caution|||Similarity ^@ Belongs to the phospholipase D family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPS15A ^@ http://purl.uniprot.org/uniprot/A0A836A542|||http://purl.uniprot.org/uniprot/W5P2W9 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||Component of the 40S ribosomal subunit.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDH11 ^@ http://purl.uniprot.org/uniprot/A0A6P3YLJ2 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DDX39B ^@ http://purl.uniprot.org/uniprot/A0A835ZP30 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SEPTIN3 ^@ http://purl.uniprot.org/uniprot/W5QBV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cytoplasm|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9940:APOBEC4 ^@ http://purl.uniprot.org/uniprot/A0A6P3TU66 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LRPPRC ^@ http://purl.uniprot.org/uniprot/A0A836D3G6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:VSNL1 ^@ http://purl.uniprot.org/uniprot/W5Q515 ^@ Function ^@ Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner. http://togogenome.org/gene/9940:PRKAB2 ^@ http://purl.uniprot.org/uniprot/W5QH48 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/9940:SLC39A14 ^@ http://purl.uniprot.org/uniprot/A0A6P3YJQ8 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101111463 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHZ1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9940:OGT ^@ http://purl.uniprot.org/uniprot/A0A6P3ES33 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.|||Cell projection|||Mitochondrion membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:METTL21C ^@ http://purl.uniprot.org/uniprot/A0A6P7EEI0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MMUT ^@ http://purl.uniprot.org/uniprot/A0A6P3EJ90 ^@ Caution|||Function|||Similarity ^@ Belongs to the methylmalonyl-CoA mutase family.|||Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HIF1AN ^@ http://purl.uniprot.org/uniprot/A0A6P3EQ16 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CREB3L3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5N5|||http://purl.uniprot.org/uniprot/W5PM30 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Endoplasmic reticulum membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UNC45B ^@ http://purl.uniprot.org/uniprot/A0A836CYD2 ^@ Caution|||Subcellular Location Annotation ^@ A band|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Z line|||perinuclear region http://togogenome.org/gene/9940:MMP12 ^@ http://purl.uniprot.org/uniprot/W5P4C9 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9940:DDB2 ^@ http://purl.uniprot.org/uniprot/W5P607 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DDB2/WDR76 family.|||Nucleus http://togogenome.org/gene/9940:STAC3 ^@ http://purl.uniprot.org/uniprot/W5PAY0 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9940:ACP3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5A6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:COTL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9I3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DNA2 ^@ http://purl.uniprot.org/uniprot/W5P4U8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family.|||Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.|||Mitochondrion|||Nucleus http://togogenome.org/gene/9940:C11H17orf67 ^@ http://purl.uniprot.org/uniprot/A0A836A848 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SFT2D2 ^@ http://purl.uniprot.org/uniprot/W5PSJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/9940:CD4 ^@ http://purl.uniprot.org/uniprot/A0A6P3CX46|||http://purl.uniprot.org/uniprot/A0A6P7DSB8 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:F2 ^@ http://purl.uniprot.org/uniprot/C8BKD1 ^@ Caution|||Function|||Similarity ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. http://togogenome.org/gene/9940:SCG2 ^@ http://purl.uniprot.org/uniprot/W5QEU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chromogranin/secretogranin protein family.|||Interacts with Secretogranin III/SCG3.|||Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.|||Secreted http://togogenome.org/gene/9940:LOC101119483 ^@ http://purl.uniprot.org/uniprot/W5NWW7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9940:EIF4EBP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EMK6 ^@ Caution|||Similarity ^@ Belongs to the eIF4E-binding protein family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101114303 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECZ0|||http://purl.uniprot.org/uniprot/W5Q739 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC30A2 ^@ http://purl.uniprot.org/uniprot/W5P641 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9940:IL12A ^@ http://purl.uniprot.org/uniprot/A0A836D852|||http://purl.uniprot.org/uniprot/Q9TU27 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-6 superfamily.|||Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.|||Heterodimer with IL12B; disulfide-linked. This heterodimer is known as interleukin IL-12 (PubMed:11023671). Heterodimer with EBI3/IL27B; not disulfide-linked. This heterodimer is known as interleukin IL-35. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).|||Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (By similarity). As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine (By similarity). Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (By similarity).|||Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NCOA5 ^@ http://purl.uniprot.org/uniprot/A0A6P3EF56 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101112491 ^@ http://purl.uniprot.org/uniprot/W5Q701 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/9940:ACTA2 ^@ http://purl.uniprot.org/uniprot/A0A835ZL29|||http://purl.uniprot.org/uniprot/W5PZK7 ^@ Caution|||Similarity ^@ Belongs to the actin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NCOA7 ^@ http://purl.uniprot.org/uniprot/W5PDE7 ^@ Similarity ^@ Belongs to the OXR1 family. http://togogenome.org/gene/9940:GFRA3 ^@ http://purl.uniprot.org/uniprot/W5Q3I4 ^@ Similarity ^@ Belongs to the GDNFR family. http://togogenome.org/gene/9940:FETUB ^@ http://purl.uniprot.org/uniprot/A0A6P3E512 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TAAR5 ^@ http://purl.uniprot.org/uniprot/W5NWU2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9940:AWAT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EMZ6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPS6KA3 ^@ http://purl.uniprot.org/uniprot/A0A6P7DJM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.|||Cytoplasm http://togogenome.org/gene/9940:NT5C3A ^@ http://purl.uniprot.org/uniprot/A0A6P3E4U5|||http://purl.uniprot.org/uniprot/A0A6P3ED16 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BCL2L1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TJ46|||http://purl.uniprot.org/uniprot/Q9MZS7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane|||Mitochondrion matrix|||Nucleus membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||centrosome|||cytosol|||synaptic vesicle membrane http://togogenome.org/gene/9940:LRRTM4 ^@ http://purl.uniprot.org/uniprot/A0A6P3YGM1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SMARCAD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TMY1 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9940:GLA ^@ http://purl.uniprot.org/uniprot/W5NU86 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/9940:PIH1D1 ^@ http://purl.uniprot.org/uniprot/A0A835ZTX5|||http://purl.uniprot.org/uniprot/W5PU56 ^@ Caution|||Similarity ^@ Belongs to the PIH1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IFNGR1 ^@ http://purl.uniprot.org/uniprot/W5NQS7 ^@ Similarity ^@ Belongs to the type II cytokine receptor family. http://togogenome.org/gene/9940:SLC6A15 ^@ http://purl.uniprot.org/uniprot/W5Q154 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.|||Membrane http://togogenome.org/gene/9940:TRIM55 ^@ http://purl.uniprot.org/uniprot/A0A6P3EG97 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CAPG ^@ http://purl.uniprot.org/uniprot/A0A6P3E766|||http://purl.uniprot.org/uniprot/A0A6P3TIX1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the villin/gelsolin family.|||Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.|||Cytoplasm|||Melanosome|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||lamellipodium|||ruffle http://togogenome.org/gene/9940:DPY19L2 ^@ http://purl.uniprot.org/uniprot/W5P5M2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/9940:KIF5B ^@ http://purl.uniprot.org/uniprot/A0A6P3EIL9 ^@ Caution|||Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MAB21L2 ^@ http://purl.uniprot.org/uniprot/W5Q0D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mab-21 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9940:TMX2 ^@ http://purl.uniprot.org/uniprot/W5PL25 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9940:RPS11 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFU8|||http://purl.uniprot.org/uniprot/W5PUK3 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uS17 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NUTF2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9M6|||http://purl.uniprot.org/uniprot/A0A6P7ER66 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM26 ^@ http://purl.uniprot.org/uniprot/A0A6P3ERY6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC52A2 ^@ http://purl.uniprot.org/uniprot/W5PWJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/9940:STMN3 ^@ http://purl.uniprot.org/uniprot/W5PLK2 ^@ Function|||Similarity ^@ Belongs to the stathmin family.|||Exhibits microtubule-destabilizing activity, which is antagonized by STAT3. http://togogenome.org/gene/9940:UGP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TIW1|||http://purl.uniprot.org/uniprot/W5QFN9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/9940:NRDC ^@ http://purl.uniprot.org/uniprot/A0A6P3DYR9|||http://purl.uniprot.org/uniprot/W5P4B3 ^@ Caution|||Similarity ^@ Belongs to the peptidase M16 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC25A6 ^@ http://purl.uniprot.org/uniprot/A0A6P3CX08|||http://purl.uniprot.org/uniprot/B2MVX0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NCF2 ^@ http://purl.uniprot.org/uniprot/W5NUE1 ^@ Similarity ^@ Belongs to the NCF2/NOXA1 family. http://togogenome.org/gene/9940:IFNG ^@ http://purl.uniprot.org/uniprot/P17773 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the type II (or gamma) interferon family.|||Homodimer. Interacts with IFNGR1 (via extracellular domain); this interaction promotes IFNGR1 dimerization.|||Released primarily from activated T lymphocytes.|||Secreted|||Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity). http://togogenome.org/gene/9940:LPAR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3T7Z6|||http://purl.uniprot.org/uniprot/A0A6P7DLP5|||http://purl.uniprot.org/uniprot/P46628 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cell surface|||Detected in brain cortex and in pituitary pars tuberalis.|||Endosome|||Interacts with RALA and GRK2 (By similarity). Interacts with GNAQ and GNA13. Interacts with CD14; the interaction is enhanced by exposure to bacterial lipopolysaccharide (LPS) (By similarity).|||Membrane|||N-glycosylated.|||Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate. Signaling mediates activation of down-stream MAP kinases. Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction. Promotes the activation of Rho and the formation of actin stress fibers. Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1. Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding. Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101121518 ^@ http://purl.uniprot.org/uniprot/A0A836ADC0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SAP18 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECM1|||http://purl.uniprot.org/uniprot/W5PW79 ^@ Caution|||Similarity ^@ Belongs to the SAP18 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EDA2R ^@ http://purl.uniprot.org/uniprot/W5PYF3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:RGS5 ^@ http://purl.uniprot.org/uniprot/A0A836AEA6|||http://purl.uniprot.org/uniprot/W5PN81 ^@ Caution|||Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101113683 ^@ http://purl.uniprot.org/uniprot/W5NR34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/9940:LOC101107675 ^@ http://purl.uniprot.org/uniprot/W5PID3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9940:SLC16A10 ^@ http://purl.uniprot.org/uniprot/W5PJH1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:FABP9 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECB6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POU3F4 ^@ http://purl.uniprot.org/uniprot/W5P873 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-3 subfamily.|||Nucleus http://togogenome.org/gene/9940:ZNF184 ^@ http://purl.uniprot.org/uniprot/A0A6P3YP14 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZBTB33 ^@ http://purl.uniprot.org/uniprot/A0A6P3EN77 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PMPCB ^@ http://purl.uniprot.org/uniprot/W5QCC2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M16 family.|||Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.|||Mitochondrion matrix http://togogenome.org/gene/9940:FH ^@ http://purl.uniprot.org/uniprot/C5IWV1 ^@ Function|||Similarity ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. http://togogenome.org/gene/9940:LOC101122736 ^@ http://purl.uniprot.org/uniprot/W5Q193 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:TSTD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7G1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATF4 ^@ http://purl.uniprot.org/uniprot/A0A6P3TNM7|||http://purl.uniprot.org/uniprot/B6Z9S5|||http://purl.uniprot.org/uniprot/W5Q5M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family.|||Nucleus http://togogenome.org/gene/9940:MRPL45 ^@ http://purl.uniprot.org/uniprot/A0A6P3E832 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SAC3D1 ^@ http://purl.uniprot.org/uniprot/A0A835ZPJ3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCNC ^@ http://purl.uniprot.org/uniprot/W5PQC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin C subfamily.|||Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.|||Nucleus http://togogenome.org/gene/9940:LEPR ^@ http://purl.uniprot.org/uniprot/Q863E2 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9940:CNMD ^@ http://purl.uniprot.org/uniprot/W5PA21 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/9940:HSD3B1 ^@ http://purl.uniprot.org/uniprot/A0A6P3CX54 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9940:MRPL42 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7I7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL42 family.|||Mitochondrion|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GLE1 ^@ http://purl.uniprot.org/uniprot/W5PJT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GLE1 family.|||Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9940:GSPT1 ^@ http://purl.uniprot.org/uniprot/W5PAZ2 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. http://togogenome.org/gene/9940:DBNL ^@ http://purl.uniprot.org/uniprot/A0A835ZPK4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABP1 family.|||Cell membrane|||Early endosome|||Endosome|||Golgi apparatus membrane|||Perikaryon|||Postsynaptic density|||Synapse|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cell cortex|||clathrin-coated vesicle membrane|||cytoskeleton|||dendrite|||lamellipodium|||neuron projection|||podosome|||ruffle http://togogenome.org/gene/9940:HDHD2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TG72|||http://purl.uniprot.org/uniprot/A0A6P7DD92 ^@ Caution|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STARD5 ^@ http://purl.uniprot.org/uniprot/A0A6P3EMM7|||http://purl.uniprot.org/uniprot/W5Q2J7 ^@ Caution|||Function ^@ May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLDN9 ^@ http://purl.uniprot.org/uniprot/A0A6P3T5M3|||http://purl.uniprot.org/uniprot/W5PLN9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||tight junction http://togogenome.org/gene/9940:TMEM106C ^@ http://purl.uniprot.org/uniprot/A0A836AAJ2|||http://purl.uniprot.org/uniprot/W5QDL2 ^@ Caution|||Similarity ^@ Belongs to the TMEM106 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RING1 ^@ http://purl.uniprot.org/uniprot/W5PGH8 ^@ Function|||Subcellular Location Annotation ^@ Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.|||Nucleus speckle http://togogenome.org/gene/9940:AGAP2 ^@ http://purl.uniprot.org/uniprot/W5P5Y0 ^@ Similarity ^@ Belongs to the centaurin gamma-like family. http://togogenome.org/gene/9940:PPIE ^@ http://purl.uniprot.org/uniprot/A0A6P9FQL1|||http://purl.uniprot.org/uniprot/C5IWT5|||http://purl.uniprot.org/uniprot/W5QFW0 ^@ Caution|||Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.|||Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GLRX5 ^@ http://purl.uniprot.org/uniprot/A0A6P7DDU1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARNTL ^@ http://purl.uniprot.org/uniprot/A0A6P3T8T7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101111505 ^@ http://purl.uniprot.org/uniprot/W5PEB3 ^@ Caution|||Similarity ^@ Belongs to the spermadhesin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:LOC101105439 ^@ http://purl.uniprot.org/uniprot/A0A836CUQ7|||http://purl.uniprot.org/uniprot/W5PBY9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PDE6H ^@ http://purl.uniprot.org/uniprot/A0A6P3YI58|||http://purl.uniprot.org/uniprot/W5QHN4 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/9940:GSK3B ^@ http://purl.uniprot.org/uniprot/A0A6P9FQG8|||http://purl.uniprot.org/uniprot/B3FL75|||http://purl.uniprot.org/uniprot/W5QEZ9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CPLX4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQJ3|||http://purl.uniprot.org/uniprot/W5P6R1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101115731 ^@ http://purl.uniprot.org/uniprot/A0A836CUR6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SGMS2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9940:TLR6 ^@ http://purl.uniprot.org/uniprot/B5DC91|||http://purl.uniprot.org/uniprot/W5NQX5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9940:INSL3 ^@ http://purl.uniprot.org/uniprot/A0A6P3CWL3|||http://purl.uniprot.org/uniprot/Q4TUB8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted|||Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DYNLT5 ^@ http://purl.uniprot.org/uniprot/W5PM05 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9940:CACUL1 ^@ http://purl.uniprot.org/uniprot/W5NQ47 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9940:LOC101122398 ^@ http://purl.uniprot.org/uniprot/A0A6P3E715|||http://purl.uniprot.org/uniprot/W5PUF2 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RNASE6 ^@ http://purl.uniprot.org/uniprot/W5PT72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9940:LOC101103439 ^@ http://purl.uniprot.org/uniprot/W5NTY6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9940:HPRT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YQN7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101115952 ^@ http://purl.uniprot.org/uniprot/W5Q993 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:C5AR1 ^@ http://purl.uniprot.org/uniprot/W5PMX5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9940:SLIT2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6S2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LONP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC56 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.|||Belongs to the peptidase S16 family.|||Interacts with PEX5. Interacts with TYSND1.|||Peroxisome matrix|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDNF ^@ http://purl.uniprot.org/uniprot/W5PAF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARMET family.|||Secreted http://togogenome.org/gene/9940:DDX18 ^@ http://purl.uniprot.org/uniprot/W5PR35 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. http://togogenome.org/gene/9940:CYSLTR2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TQR8 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZC2HC1C ^@ http://purl.uniprot.org/uniprot/W5NU89 ^@ Similarity ^@ Belongs to the ZC2HC1 family. http://togogenome.org/gene/9940:LOC101116245 ^@ http://purl.uniprot.org/uniprot/A0A836CXA8 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101117181 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/9940:NUBP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EG89|||http://purl.uniprot.org/uniprot/W5P7E1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Cell projection|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101105840 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBN0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OTC ^@ http://purl.uniprot.org/uniprot/P84010 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-89 negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals.|||Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline (PubMed:14527149). The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion (Probable).|||Homotrimer.|||Mitochondrion matrix|||Negatively regulated by lysine acetylation.|||Residues 88-96, 111-125 and 247-283 form flexible loops whose positions are affected on substrate binding. http://togogenome.org/gene/9940:UBE2J2 ^@ http://purl.uniprot.org/uniprot/A0A6P7EMN0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101111906 ^@ http://purl.uniprot.org/uniprot/W5P3C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 20 family.|||Lysosome http://togogenome.org/gene/9940:PPP4R2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YRM8|||http://purl.uniprot.org/uniprot/W5PI71 ^@ Caution|||Similarity ^@ Belongs to the PPP4R2 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SOD3 ^@ http://purl.uniprot.org/uniprot/W5NQP5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems.|||Nucleus http://togogenome.org/gene/9940:MTSS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHC5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:USP3 ^@ http://purl.uniprot.org/uniprot/W5QHY4|||http://purl.uniprot.org/uniprot/W5QHY5 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9940:XPO7 ^@ http://purl.uniprot.org/uniprot/W5PLR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9940:ELOF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TNG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELOF1 family.|||Nucleus|||Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. http://togogenome.org/gene/9940:LOC101109212 ^@ http://purl.uniprot.org/uniprot/W5P3J0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/9940:ADAM17 ^@ http://purl.uniprot.org/uniprot/A0A6P3E2F7|||http://purl.uniprot.org/uniprot/W5Q0N8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PABIR1 ^@ http://purl.uniprot.org/uniprot/W5PF56 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/9940:ABCG5 ^@ http://purl.uniprot.org/uniprot/W5P9W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9940:SFXN3 ^@ http://purl.uniprot.org/uniprot/A0A6P7DBE2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9940:HTR1A ^@ http://purl.uniprot.org/uniprot/A0A6P3YN36|||http://purl.uniprot.org/uniprot/W5P5K8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||dendrite http://togogenome.org/gene/9940:SPATA6 ^@ http://purl.uniprot.org/uniprot/W5P1E5 ^@ Similarity ^@ Belongs to the SPATA6 family. http://togogenome.org/gene/9940:EDC3 ^@ http://purl.uniprot.org/uniprot/A0A835ZWJ4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EDC3 family.|||P-body|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MAPK6 ^@ http://purl.uniprot.org/uniprot/A0A6P3TFU3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9940:LOC101106734 ^@ http://purl.uniprot.org/uniprot/A0A6P3E059 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BBS7 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDI5 ^@ Function|||Subunit ^@ Part of BBSome complex.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. http://togogenome.org/gene/9940:RETSAT ^@ http://purl.uniprot.org/uniprot/A0A836AJL2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HIGD2A ^@ http://purl.uniprot.org/uniprot/A0A6P3EDU7|||http://purl.uniprot.org/uniprot/W5NVU5 ^@ Caution|||Subcellular Location Annotation ^@ Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RAP2B ^@ http://purl.uniprot.org/uniprot/W5Q0M7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9940:FXYD1 ^@ http://purl.uniprot.org/uniprot/W5P3P0 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone.|||Belongs to the FXYD family.|||Homotetramer. Monomer. Regulatory subunit of the sodium/potassium-transporting ATPase (NKA) which is composed of a catalytic alpha subunit, a non-catalytic beta subunit and an additional regulatory subunit. The monomeric form associates with NKA while the oligomeric form does not. Interacts with the catalytic alpha-1 subunit ATP1A1. Also interacts with the catalytic alpha-2 and alpha-3 subunits ATP1A2 and ATP1A3. Very little interaction with ATP1A1, ATP1A2 or ATP1A3 when phosphorylated at Ser-83. Interacts with the non-catalytic beta-1 subunit ATP1B1. Oxidative stress decreases interaction with ATP1A1 but increases interaction with ATP1B1.|||Major plasma membrane substrate for cAMP-dependent protein kinase (PKA) and protein kinase C (PKC) in several different tissues. Phosphorylated in response to insulin and adrenergic stimulation. Phosphorylation at Ser-88 stimulates sodium/potassium-transporting ATPase activity while the unphosphorylated form inhibits sodium/potassium-transporting ATPase activity. Phosphorylation increases tetramerization, decreases binding to ATP1A1 and reduces inhibition of ATP1A1 activity. Phosphorylation at Ser-83 leads to greatly reduced interaction with ATP1A1, ATP1A2 and ATP1A3. May be phosphorylated by DMPK.|||Palmitoylation increases half-life and stability and is enhanced upon phosphorylation at Ser-88 by PKA.|||T-tubule|||The cytoplasmic domain is sufficient to regulate sodium/potassium-transporting ATPase activity.|||caveola|||sarcolemma http://togogenome.org/gene/9940:DRD1 ^@ http://purl.uniprot.org/uniprot/W5PPK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.|||Membrane|||dendritic spine http://togogenome.org/gene/9940:RNF114 ^@ http://purl.uniprot.org/uniprot/A0A6P3EF62|||http://purl.uniprot.org/uniprot/W5PUG0 ^@ Caution|||Subunit ^@ Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BLVRA ^@ http://purl.uniprot.org/uniprot/W5Q633 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.|||Monomer.|||Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.|||cytosol http://togogenome.org/gene/9940:EXOG ^@ http://purl.uniprot.org/uniprot/W5NTM1 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/9940:SHBG ^@ http://purl.uniprot.org/uniprot/A0A6P7EHR7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:GFOD1 ^@ http://purl.uniprot.org/uniprot/W5PVV6 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/9940:ACVR2A ^@ http://purl.uniprot.org/uniprot/Q28560 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity). Interacts with type I receptor ACVR1 (By similarity).|||Membrane|||On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6. http://togogenome.org/gene/9940:MISP3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YLB5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM86A ^@ http://purl.uniprot.org/uniprot/W5PHV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/9940:PGAM2 ^@ http://purl.uniprot.org/uniprot/A0A835ZX50 ^@ Caution|||Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MFSD14A ^@ http://purl.uniprot.org/uniprot/W5Q8X6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9940:LOC101115694 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB29|||http://purl.uniprot.org/uniprot/W5PC47 ^@ Caution|||Similarity ^@ Belongs to the cytochrome c oxidase VIIa family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STAT3 ^@ http://purl.uniprot.org/uniprot/W5NTT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9940:TMEM184B ^@ http://purl.uniprot.org/uniprot/A0A836D5P4 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATP5F1D ^@ http://purl.uniprot.org/uniprot/A0A8N7XJE2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase epsilon chain family.|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PDHX ^@ http://purl.uniprot.org/uniprot/W5QBN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9940:DNAJC21 ^@ http://purl.uniprot.org/uniprot/A0A836CVM3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:WASHC3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC09 ^@ Caution|||Similarity ^@ Belongs to the CCDC53 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OXT ^@ http://purl.uniprot.org/uniprot/P13389 ^@ Function|||Similarity|||Subunit ^@ Belongs to the vasopressin/oxytocin family.|||Interacts with oxytocin receptor (Ki=1.5 nM) (By similarity). Interacts with vasopressin V1aR/AVPR1A (Ki=37 nM), V1bR/AVPR1B (Ki=222 nM), and V2R/AVPR2 receptors (Ki=823 nM) (By similarity).|||Neurophysin 1 specifically binds oxytocin.|||Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (By similarity). http://togogenome.org/gene/9940:GPRIN3 ^@ http://purl.uniprot.org/uniprot/W5NQE9 ^@ Function ^@ May be involved in neurite outgrowth. http://togogenome.org/gene/9940:C1H1orf194 ^@ http://purl.uniprot.org/uniprot/A0A836AID1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PSME3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDK6|||http://purl.uniprot.org/uniprot/W5P0N8 ^@ Caution|||Similarity ^@ Belongs to the PA28 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GLB1L ^@ http://purl.uniprot.org/uniprot/A0A6P3E216|||http://purl.uniprot.org/uniprot/W5QFF0 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 35 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCNH ^@ http://purl.uniprot.org/uniprot/A0A6P3E513|||http://purl.uniprot.org/uniprot/W5Q318 ^@ Caution|||Function|||Similarity|||Subunit ^@ Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.|||Belongs to the cyclin family.|||Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MCOLN3 ^@ http://purl.uniprot.org/uniprot/W5PXF7 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/9940:TYW3 ^@ http://purl.uniprot.org/uniprot/W5PSH3 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. http://togogenome.org/gene/9940:GRIK3 ^@ http://purl.uniprot.org/uniprot/W5QER0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9940:MAPRE3 ^@ http://purl.uniprot.org/uniprot/W5QCK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/9940:HKDC1 ^@ http://purl.uniprot.org/uniprot/W5P5V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hexokinase family.|||Membrane|||Mitochondrion outer membrane|||cytosol http://togogenome.org/gene/9940:MTMR10 ^@ http://purl.uniprot.org/uniprot/W5Q3Q8 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9940:ADH1C ^@ http://purl.uniprot.org/uniprot/A0A6P3EDU1 ^@ Caution|||Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CPB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZZ9|||http://purl.uniprot.org/uniprot/W5P5L0 ^@ Caution|||Similarity ^@ Belongs to the peptidase M14 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RFT1 ^@ http://purl.uniprot.org/uniprot/W5NQD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RFT1 family.|||May be involved in N-linked oligosaccharide assembly.|||Membrane http://togogenome.org/gene/9940:TP-1 ^@ http://purl.uniprot.org/uniprot/P56828 ^@ Developmental Stage|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.|||Constitutively and exclusively expressed in the mononuclear cells of the extraembryonic trophectoderm.|||IFN-tau genes are intronless. They evolved from IFN-omega genes in the ruminantia suborder and have continued to duplicate independently in different lineages of the ruminantia. They code for proteins very similar in sequence but with different biological potency and pattern of expression.|||Major secretory product synthesized by the sheep conceptus between days 13 and 21 of pregnancy.|||Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.|||Secreted http://togogenome.org/gene/9940:AASS ^@ http://purl.uniprot.org/uniprot/W5QB58 ^@ Similarity ^@ In the C-terminal section; belongs to the saccharopine dehydrogenase family.|||In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/9940:MGST1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC95|||http://purl.uniprot.org/uniprot/A0A6P7DXS7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPS25 ^@ http://purl.uniprot.org/uniprot/A0A6P7D1J1|||http://purl.uniprot.org/uniprot/Q6Q311 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PDP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YKP0|||http://purl.uniprot.org/uniprot/A0A6P3YN27|||http://purl.uniprot.org/uniprot/W5PEE7 ^@ Caution|||Similarity ^@ Belongs to the PP2C family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRPF3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TF43|||http://purl.uniprot.org/uniprot/A0A6P3TQ60 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Nucleus|||Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC39A7 ^@ http://purl.uniprot.org/uniprot/A0A835ZV02|||http://purl.uniprot.org/uniprot/C7BDW5 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZNF215 ^@ http://purl.uniprot.org/uniprot/A0A6P3EKH5|||http://purl.uniprot.org/uniprot/W5Q4D2 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NR1I3 ^@ http://purl.uniprot.org/uniprot/W5PJR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9940:SPATS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3T7W2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IGBP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ES16 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UBE2Q2 ^@ http://purl.uniprot.org/uniprot/A0A836CWN2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BRAF ^@ http://purl.uniprot.org/uniprot/W5PVT2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/9940:NDN ^@ http://purl.uniprot.org/uniprot/A0A6P3EE67 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C18H15orf40 ^@ http://purl.uniprot.org/uniprot/W5PX33 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/9940:LOC101120889 ^@ http://purl.uniprot.org/uniprot/A0A6P7DI25 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/9940:PHAX ^@ http://purl.uniprot.org/uniprot/A0A6P3EDS9|||http://purl.uniprot.org/uniprot/W5Q9Z8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PHAX family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TUBGCP4 ^@ http://purl.uniprot.org/uniprot/W5PJU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9940:CAMK2D ^@ http://purl.uniprot.org/uniprot/W5QAM4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9940:GPR18 ^@ http://purl.uniprot.org/uniprot/W5Q6X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9940:LOC101102001 ^@ http://purl.uniprot.org/uniprot/A0A836CXP0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101109940 ^@ http://purl.uniprot.org/uniprot/W5NR20 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC25 family.|||Cell membrane|||Endomembrane system|||Interacts (via cytoplasmic region) with ILK. http://togogenome.org/gene/9940:ZNF496 ^@ http://purl.uniprot.org/uniprot/A0A6P7E3Z2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:GPR65 ^@ http://purl.uniprot.org/uniprot/A0A6P3E841|||http://purl.uniprot.org/uniprot/W5Q814 ^@ Caution|||Similarity ^@ Belongs to the G-protein coupled receptor 1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UGT2B7 ^@ http://purl.uniprot.org/uniprot/F1CGV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9940:RPAIN ^@ http://purl.uniprot.org/uniprot/A0A6P3ED20|||http://purl.uniprot.org/uniprot/W5P029 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POLR3GL ^@ http://purl.uniprot.org/uniprot/A0A6P3TN70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9940:TMEM63A ^@ http://purl.uniprot.org/uniprot/W5Q829 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/9940:PYM1 ^@ http://purl.uniprot.org/uniprot/W5PMG4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pym family.|||Cytoplasm|||Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex. http://togogenome.org/gene/9940:PSEN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TPH6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Cytoplasmic granule|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||Synapse|||The PAL motif is required for normal active site conformation.|||axon|||neuron projection http://togogenome.org/gene/9940:LOC101109039 ^@ http://purl.uniprot.org/uniprot/W5P8M3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:LOC443035 ^@ http://purl.uniprot.org/uniprot/O97965 ^@ Function|||Subcellular Location Annotation ^@ Chromosome|||Involved in nuclear basic protein transition: histones are replaced by spermatid specific proteins which are themselves replaced by protamines in late spermatids.|||Nucleus http://togogenome.org/gene/9940:MRPL2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EET4|||http://purl.uniprot.org/uniprot/W5P5T0 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL2 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101119384 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC36 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KBTBD3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EA33 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CRISP3 ^@ http://purl.uniprot.org/uniprot/D6PX64 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:GRSF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5K6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TECRL ^@ http://purl.uniprot.org/uniprot/W5P809 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane http://togogenome.org/gene/9940:ELAVL4 ^@ http://purl.uniprot.org/uniprot/W5P2B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm|||Perikaryon|||axon|||dendrite|||growth cone http://togogenome.org/gene/9940:KCNH5 ^@ http://purl.uniprot.org/uniprot/W5QJ21 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:PLEK ^@ http://purl.uniprot.org/uniprot/A0A6P3EAU7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CALHM5 ^@ http://purl.uniprot.org/uniprot/A0A6P3TPS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9940:ALDOB ^@ http://purl.uniprot.org/uniprot/P52210|||http://purl.uniprot.org/uniprot/W5PCA0 ^@ Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I fructose-bisphosphate aldolase family.|||Homotetramer. Interacts with BBS1, BBS2, BBS4 and BBS7.|||In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.|||centriolar satellite http://togogenome.org/gene/9940:DYA ^@ http://purl.uniprot.org/uniprot/Q708G2 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9940:KLHL21 ^@ http://purl.uniprot.org/uniprot/W5PNZ2 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/9940:FUT8 ^@ http://purl.uniprot.org/uniprot/A0A6P3TR44|||http://purl.uniprot.org/uniprot/A0A6P3YK89 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 23 family.|||Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.|||Golgi stack membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NPY ^@ http://purl.uniprot.org/uniprot/P14765 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the NPY family.|||NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.|||One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.|||Secreted|||The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).|||neuronal dense core vesicle http://togogenome.org/gene/9940:TDP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TRA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosyl-DNA phosphodiesterase family.|||Nucleus http://togogenome.org/gene/9940:SLC25A33 ^@ http://purl.uniprot.org/uniprot/B2MVX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9940:TMEM14A ^@ http://purl.uniprot.org/uniprot/A0A6P3EJ96|||http://purl.uniprot.org/uniprot/A0A6P7D9V6 ^@ Caution|||Similarity ^@ Belongs to the TMEM14 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CTC1 ^@ http://purl.uniprot.org/uniprot/W5QCT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CTC1 family.|||Nucleus|||telomere http://togogenome.org/gene/9940:CLDN4 ^@ http://purl.uniprot.org/uniprot/A0A6P3CX64|||http://purl.uniprot.org/uniprot/D6R6U1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||tight junction http://togogenome.org/gene/9940:CCT6A ^@ http://purl.uniprot.org/uniprot/W5PJX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9940:SLC26A7 ^@ http://purl.uniprot.org/uniprot/W5PIL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/9940:MICOS13 ^@ http://purl.uniprot.org/uniprot/W5PCE9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic13 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9940:LOC101121643 ^@ http://purl.uniprot.org/uniprot/A0A6P3DYW6 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101110417 ^@ http://purl.uniprot.org/uniprot/W5NUU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG28 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9940:CSF2 ^@ http://purl.uniprot.org/uniprot/P28773 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GM-CSF family.|||Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.|||Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits (By similarity).|||Secreted http://togogenome.org/gene/9940:NPM3 ^@ http://purl.uniprot.org/uniprot/W5Q628 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/9940:AOX1 ^@ http://purl.uniprot.org/uniprot/W5Q3F9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9940:TARS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENF7|||http://purl.uniprot.org/uniprot/W5PR81 ^@ Caution|||Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POLR3F ^@ http://purl.uniprot.org/uniprot/A0A6P3TMF1|||http://purl.uniprot.org/uniprot/W5NQ69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9940:YBEY ^@ http://purl.uniprot.org/uniprot/W5PUE0 ^@ Similarity ^@ Belongs to the endoribonuclease YbeY family. http://togogenome.org/gene/9940:SEC13 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECE9|||http://purl.uniprot.org/uniprot/W5PPQ6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Lysosome membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nuclear pore complex http://togogenome.org/gene/9940:APOA4 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECT1 ^@ Caution|||Similarity ^@ Belongs to the apolipoprotein A1/A4/E family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DBX1 ^@ http://purl.uniprot.org/uniprot/W5PEX0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:RPS12 ^@ http://purl.uniprot.org/uniprot/A0A6P3EH34|||http://purl.uniprot.org/uniprot/A0A835ZMF4 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SKA1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EG34 ^@ Caution|||Similarity ^@ Belongs to the SKA1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TET1 ^@ http://purl.uniprot.org/uniprot/W5P511 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Chromosome|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/9940:HEBP1 ^@ http://purl.uniprot.org/uniprot/W5QI36 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/9940:RNF182 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJP0|||http://purl.uniprot.org/uniprot/A0A6P3TI93 ^@ Caution|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with ATP6V0C.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GPR101 ^@ http://purl.uniprot.org/uniprot/A0A6P3YQN3|||http://purl.uniprot.org/uniprot/W5PIA8 ^@ Caution|||Similarity ^@ Belongs to the G-protein coupled receptor 1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PDE6C ^@ http://purl.uniprot.org/uniprot/W5NZF9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9940:CYM ^@ http://purl.uniprot.org/uniprot/P18276 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase A1 family.|||Chymosin is synthesized in the mucosa of the stomach. The enzyme hydrolyzes casein to paracasein.|||Monomer. http://togogenome.org/gene/9940:CTXN3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YJB6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BBOX1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EMJ0|||http://purl.uniprot.org/uniprot/A0A6P7F038 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-BBH/TMLD family.|||Catalyzes the formation of L-carnitine from gamma-butyrobetaine.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EIF5B ^@ http://purl.uniprot.org/uniprot/A0A836A7D6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PAH ^@ http://purl.uniprot.org/uniprot/A0A6P3E820|||http://purl.uniprot.org/uniprot/W5Q2V2 ^@ Caution|||Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NCOA1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TKJ4|||http://purl.uniprot.org/uniprot/A0A6P3TNZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/9940:LCMT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ELN5|||http://purl.uniprot.org/uniprot/W5QAQ5 ^@ Caution|||Function|||Similarity ^@ Belongs to the methyltransferase superfamily. LCMT family.|||Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRPS18A ^@ http://purl.uniprot.org/uniprot/A0A6P3ECK7|||http://purl.uniprot.org/uniprot/W5PEL4 ^@ Caution|||Subcellular Location Annotation ^@ Mitochondrion|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DKKL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TUR4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TTPAL ^@ http://purl.uniprot.org/uniprot/A0A6P3EJ27 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MCU ^@ http://purl.uniprot.org/uniprot/W5PBG4 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCU (TC 1.A.77) family.|||Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.|||Mitochondrion inner membrane http://togogenome.org/gene/9940:LOC101123167 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZ13 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DQA ^@ http://purl.uniprot.org/uniprot/W1IAM8 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9940:ROMO1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TMR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.|||Mitochondrion inner membrane http://togogenome.org/gene/9940:OXTR ^@ http://purl.uniprot.org/uniprot/Q9BDP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9940:BRK1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EIK7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BRK1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytoskeleton http://togogenome.org/gene/9940:KCNAB1 ^@ http://purl.uniprot.org/uniprot/W5NYG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9940:GEMIN2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EMT6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gemin-2 family.|||Cytoplasm|||Part of the core SMN complex.|||The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101105655 ^@ http://purl.uniprot.org/uniprot/W5Q5J0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:KIF27 ^@ http://purl.uniprot.org/uniprot/W5PGS0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9940:CCL16 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECV3 ^@ Caution|||Similarity ^@ Belongs to the intercrine beta (chemokine CC) family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101119050 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAS3|||http://purl.uniprot.org/uniprot/W5QD93 ^@ Caution|||Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TBXT ^@ http://purl.uniprot.org/uniprot/A0A6P3E8V8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DGKA ^@ http://purl.uniprot.org/uniprot/A0A6P3TBM7 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9940:CXHXorf65 ^@ http://purl.uniprot.org/uniprot/A0A6P3ES21 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CIAO2A ^@ http://purl.uniprot.org/uniprot/A0A6P3E669|||http://purl.uniprot.org/uniprot/W5QHV9 ^@ Caution|||Similarity ^@ Belongs to the MIP18 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM185B ^@ http://purl.uniprot.org/uniprot/A0A836AGH0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TBCA ^@ http://purl.uniprot.org/uniprot/A0A6P3YMG4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCA family.|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Tubulin-folding protein; involved in the early step of the tubulin folding pathway.|||cytoskeleton http://togogenome.org/gene/9940:XPOT ^@ http://purl.uniprot.org/uniprot/A0A6P3EAN7|||http://purl.uniprot.org/uniprot/A0A6P7DWT9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. http://togogenome.org/gene/9940:SPTBN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YKN4|||http://purl.uniprot.org/uniprot/W5NZX9 ^@ Caution|||Similarity ^@ Belongs to the spectrin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GON7 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBZ4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DCUN1D1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YH46 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:WDR36 ^@ http://purl.uniprot.org/uniprot/A0A6P3E560 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101113632 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECX0 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SPESP1 ^@ http://purl.uniprot.org/uniprot/A0A0M4AT35|||http://purl.uniprot.org/uniprot/A0A6P9FR57 ^@ Caution|||Function|||Similarity ^@ Belongs to the SPESP1 family.|||Involved in fertilization ability of sperm.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM59 ^@ http://purl.uniprot.org/uniprot/W5PAC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM59 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9940:KEF53_p01 ^@ http://purl.uniprot.org/uniprot/P24959|||http://purl.uniprot.org/uniprot/Q5MA65 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme b groups non-covalently.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.|||Membrane|||Mitochondrion inner membrane|||The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.|||The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools. http://togogenome.org/gene/9940:LOC101107947 ^@ http://purl.uniprot.org/uniprot/A0A836D4A6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RBP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E584|||http://purl.uniprot.org/uniprot/W5PAR8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC25A17 ^@ http://purl.uniprot.org/uniprot/B2MVX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9940:ENKD1 ^@ http://purl.uniprot.org/uniprot/W5NYS2 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9940:HACL1 ^@ http://purl.uniprot.org/uniprot/W5Q0R8 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/9940:BHLHE40 ^@ http://purl.uniprot.org/uniprot/A0A836CSN8|||http://purl.uniprot.org/uniprot/B3F209 ^@ Caution|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Homodimer. Heterodimer with BHLHE41/DEC2. Interacts with TCF3/E47. Interacts with ubiquitin-conjugating enzyme UBE2I/UBC9. Interacts with HDAC1, SUMO1, RXRA and BMAL1 (By similarity).|||Nucleus|||Sumoylation inhibits its ubiquitination and promotes its negative regulation of the CLOCK-BMAL1 heterodimer transcriptional activator activity.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1|BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway (By similarity). Represses the transcription of NR0B2 and attentuates the transactivation of NR0B2 by the CLOCK-BMAL1 complex (By similarity). Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system (By similarity).|||Ubiquitinated; which may lead to proteasomal degradation. http://togogenome.org/gene/9940:ACSS2 ^@ http://purl.uniprot.org/uniprot/A0A836A5U9|||http://purl.uniprot.org/uniprot/W5PM93|||http://purl.uniprot.org/uniprot/W5PM94 ^@ Caution|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRPH2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EES7|||http://purl.uniprot.org/uniprot/W5P133 ^@ Caution|||Similarity ^@ Belongs to the PRPH2/ROM1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CHMP4B ^@ http://purl.uniprot.org/uniprot/A0A6P3E9A4|||http://purl.uniprot.org/uniprot/W5PGC1 ^@ Caution|||Similarity ^@ Belongs to the SNF7 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRKCQ ^@ http://purl.uniprot.org/uniprot/A0A6P3TJ58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/9940:ERC1 ^@ http://purl.uniprot.org/uniprot/W5PSP1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9940:KCNJ10 ^@ http://purl.uniprot.org/uniprot/A0A6P3E670|||http://purl.uniprot.org/uniprot/W5PBW3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PTPN11 ^@ http://purl.uniprot.org/uniprot/A0A6P3EMB8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DEFB105B ^@ http://purl.uniprot.org/uniprot/W5P8X7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9940:RPA1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FRE4|||http://purl.uniprot.org/uniprot/C5ISB1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.|||Belongs to the replication factor A protein 1 family.|||Component of the heterotrimeric canonical replication protein A complex (RPA).|||PML body|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARL5A ^@ http://purl.uniprot.org/uniprot/C5IWS8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9940:MSS51 ^@ http://purl.uniprot.org/uniprot/A0A6P3TA98 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101120455 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZG3 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FHL2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7F2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GLRX2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8I6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OSCP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3DY27 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TXNDC9 ^@ http://purl.uniprot.org/uniprot/A0A836AA03 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:WEE2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDB3|||http://purl.uniprot.org/uniprot/W5PX21 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.|||Binds 2 magnesium ions per subunit.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:METTL3 ^@ http://purl.uniprot.org/uniprot/W5QEC3 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/9940:KCNMA1 ^@ http://purl.uniprot.org/uniprot/A0A0A7ETA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.|||Membrane http://togogenome.org/gene/9940:UGDH ^@ http://purl.uniprot.org/uniprot/A0A6P3EAC3|||http://purl.uniprot.org/uniprot/W5PQL0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.|||Homohexamer.|||Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MBTD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TT62 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:LOC101123417 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQ38|||http://purl.uniprot.org/uniprot/W5PHK5 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:COPZ1 ^@ http://purl.uniprot.org/uniprot/W5Q3X7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes small subunit family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. http://togogenome.org/gene/9940:ERH ^@ http://purl.uniprot.org/uniprot/A0A6P3EGC5 ^@ Caution|||Function|||Similarity ^@ Belongs to the E(R) family.|||May have a role in the cell cycle.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM69 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3W6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RTCB ^@ http://purl.uniprot.org/uniprot/A0A6P3E388|||http://purl.uniprot.org/uniprot/W5Q9D9 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Catalytic component of the tRNA-splicing ligase complex.|||Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.|||Cytoplasm|||Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPARG ^@ http://purl.uniprot.org/uniprot/Q8HZ56|||http://purl.uniprot.org/uniprot/W5Q4M7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Cytoplasm|||Heterodimer with other nuclear receptors.|||Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.|||Nucleus http://togogenome.org/gene/9940:MKNK1 ^@ http://purl.uniprot.org/uniprot/A0A6P3T8V1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9940:LOC101116336 ^@ http://purl.uniprot.org/uniprot/W5QA37 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/9940:LOC101103401 ^@ http://purl.uniprot.org/uniprot/W5NS45 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9940:LOC101118248 ^@ http://purl.uniprot.org/uniprot/W5PM66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9940:PRIMPOL ^@ http://purl.uniprot.org/uniprot/A0A836CPR0 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic-type primase small subunit family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLPPR1 ^@ http://purl.uniprot.org/uniprot/W5PCF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Cell membrane|||May play a role in neurite outgrowth and neurogenesis.|||Membrane|||neuron projection http://togogenome.org/gene/9940:EPB41 ^@ http://purl.uniprot.org/uniprot/W5NX11|||http://purl.uniprot.org/uniprot/W5NX12 ^@ Subcellular Location Annotation ^@ Nucleus|||cell cortex http://togogenome.org/gene/9940:TSSK6 ^@ http://purl.uniprot.org/uniprot/A0A2R8G2P5|||http://purl.uniprot.org/uniprot/A0A6P3TLS1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9940:TTC9C ^@ http://purl.uniprot.org/uniprot/A0A6P3EPL2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCN2 ^@ http://purl.uniprot.org/uniprot/C7EDS5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9940:C26H8orf48 ^@ http://purl.uniprot.org/uniprot/A0A836CR03 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HEBP2 ^@ http://purl.uniprot.org/uniprot/W5NRM2 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/9940:SCPEP1 ^@ http://purl.uniprot.org/uniprot/W5PBM9 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9940:MDH1 ^@ http://purl.uniprot.org/uniprot/W5QFQ0 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family.|||Homodimer. http://togogenome.org/gene/9940:NSMCE2 ^@ http://purl.uniprot.org/uniprot/W5PEH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NSE2 family.|||Nucleus http://togogenome.org/gene/9940:RNF4 ^@ http://purl.uniprot.org/uniprot/A0A6P3YJV1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:QRFP ^@ http://purl.uniprot.org/uniprot/B2KTD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RFamide neuropeptide family.|||Secreted http://togogenome.org/gene/9940:SRGN ^@ http://purl.uniprot.org/uniprot/A0A835ZJZ8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EIF5A2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E541 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Membrane|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.|||mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. http://togogenome.org/gene/9940:CLPSL2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJR5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAR1 ^@ http://purl.uniprot.org/uniprot/W5PBX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acyl-CoA reductase family.|||Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.|||Peroxisome membrane http://togogenome.org/gene/9940:DFFA ^@ http://purl.uniprot.org/uniprot/A0A835ZXF7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101115567 ^@ http://purl.uniprot.org/uniprot/W5Q7C3 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:XRCC4 ^@ http://purl.uniprot.org/uniprot/A0A836A6L1|||http://purl.uniprot.org/uniprot/W5Q208 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XRCC4 subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101107687 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECA6|||http://purl.uniprot.org/uniprot/W5QGA9 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TIMP1 ^@ http://purl.uniprot.org/uniprot/P50122 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protease inhibitor I35 (TIMP) family.|||Interacts with MMP1, MMP3, MMP10 and MMP13, but has only very low affinity for MMP14. Interacts with CD63; identified in a complex with CD63 and ITGB1 (By similarity).|||Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity).|||N-glycosylated.|||Secreted|||The activity of TIMP1 is dependent on the presence of disulfide bonds. http://togogenome.org/gene/9940:C19H3orf18 ^@ http://purl.uniprot.org/uniprot/A0A6P3EN95 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101114053 ^@ http://purl.uniprot.org/uniprot/W5PRY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:TSPYL4 ^@ http://purl.uniprot.org/uniprot/A0A6P3TRG3 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9940:DUSP11 ^@ http://purl.uniprot.org/uniprot/A0A836A7A1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101118285 ^@ http://purl.uniprot.org/uniprot/A0A6P3EH44|||http://purl.uniprot.org/uniprot/W5PMY4 ^@ Caution|||Similarity ^@ Belongs to the ATG8 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POLR2J ^@ http://purl.uniprot.org/uniprot/A0A6P3EGI0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TPRKB ^@ http://purl.uniprot.org/uniprot/A0A6P3TE34 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/9940:NDUFA8 ^@ http://purl.uniprot.org/uniprot/A0A8N7XJG2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA8 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane|||Mitochondrion intermembrane space|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TNFSF13 ^@ http://purl.uniprot.org/uniprot/W5PXV6 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9940:PLAC8L1 ^@ http://purl.uniprot.org/uniprot/W5NWE3 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9940:HAO1 ^@ http://purl.uniprot.org/uniprot/W5NPE3 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/9940:RARB ^@ http://purl.uniprot.org/uniprot/W5P2M8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9940:BTG1 ^@ http://purl.uniprot.org/uniprot/B7U799 ^@ Function|||Similarity ^@ Anti-proliferative protein.|||Belongs to the BTG family. http://togogenome.org/gene/9940:EIF6 ^@ http://purl.uniprot.org/uniprot/A0A6P3TUB9|||http://purl.uniprot.org/uniprot/A0A6P9FQI1 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).|||Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:C1S ^@ http://purl.uniprot.org/uniprot/A0A6P3TKJ3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:MCM9 ^@ http://purl.uniprot.org/uniprot/W5PFE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9940:LOC101116254 ^@ http://purl.uniprot.org/uniprot/W5P8Q8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:RCAN3 ^@ http://purl.uniprot.org/uniprot/W5P9D3 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/9940:RAB20 ^@ http://purl.uniprot.org/uniprot/A0A6P3EI01 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARHGEF3 ^@ http://purl.uniprot.org/uniprot/W5PZJ3 ^@ Function|||Subcellular Location Annotation ^@ Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.|||Cytoplasm http://togogenome.org/gene/9940:TRIM2 ^@ http://purl.uniprot.org/uniprot/W5NZD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/9940:ZSCAN12 ^@ http://purl.uniprot.org/uniprot/W5Q8N0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:ADK ^@ http://purl.uniprot.org/uniprot/W5PFM8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.|||Belongs to the carbohydrate kinase PfkB family.|||Binds 3 Mg(2+) ions per subunit.|||Monomer.|||Nucleus http://togogenome.org/gene/9940:CMTM5 ^@ http://purl.uniprot.org/uniprot/W5QDF9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:C1H3orf80 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZW4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZC3H12B ^@ http://purl.uniprot.org/uniprot/A0A6P3YPQ7|||http://purl.uniprot.org/uniprot/W5P4G0 ^@ Caution|||Similarity ^@ Belongs to the ZC3H12 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IAH1 ^@ http://purl.uniprot.org/uniprot/W5Q0L0 ^@ Function|||Similarity ^@ Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.|||Probable lipase. http://togogenome.org/gene/9940:LOC101120294 ^@ http://purl.uniprot.org/uniprot/W5PB55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:FEZ1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EPH2|||http://purl.uniprot.org/uniprot/A0A6P3T8H1 ^@ Caution|||Similarity ^@ Belongs to the zygin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DUSP10 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8K1|||http://purl.uniprot.org/uniprot/W5PUM4 ^@ Caution|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FZD3 ^@ http://purl.uniprot.org/uniprot/W5Q028 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9940:LOC101113073 ^@ http://purl.uniprot.org/uniprot/A0A6P3TU87 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPTC7 ^@ http://purl.uniprot.org/uniprot/A0A835ZRL4|||http://purl.uniprot.org/uniprot/W5Q6K7 ^@ Caution|||Similarity ^@ Belongs to the PP2C family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ERLIN2 ^@ http://purl.uniprot.org/uniprot/W5NRD1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the band 7/mec-2 family.|||Endoplasmic reticulum membrane|||Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.|||Membrane http://togogenome.org/gene/9940:LOC101105358 ^@ http://purl.uniprot.org/uniprot/W5P9D0 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/9940:VPS41 ^@ http://purl.uniprot.org/uniprot/W5Q8J8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS41 family.|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.|||Vesicle|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/9940:NKIRAS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YPJ4|||http://purl.uniprot.org/uniprot/A0A6P3YPZ5 ^@ Caution|||Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101117748 ^@ http://purl.uniprot.org/uniprot/W5QDC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:PLA1A ^@ http://purl.uniprot.org/uniprot/W5QET9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9940:TAS2R7 ^@ http://purl.uniprot.org/uniprot/W5QGH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.|||Membrane http://togogenome.org/gene/9940:OTUD7B ^@ http://purl.uniprot.org/uniprot/W5QHV5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9940:TRAPPC4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EA87|||http://purl.uniprot.org/uniprot/W5PSI4 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cis-Golgi network http://togogenome.org/gene/9940:ADAMTS1 ^@ http://purl.uniprot.org/uniprot/W5PZU6 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9940:SEC24C ^@ http://purl.uniprot.org/uniprot/A0A6P3ES24|||http://purl.uniprot.org/uniprot/W5PDT0|||http://purl.uniprot.org/uniprot/W5PDT3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytosol http://togogenome.org/gene/9940:GMPS ^@ http://purl.uniprot.org/uniprot/A0A6P3YFH9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CA11 ^@ http://purl.uniprot.org/uniprot/A0A836CXA3|||http://purl.uniprot.org/uniprot/Q95203 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-carbonic anhydrase family.|||Does not have a catalytic activity.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101116968 ^@ http://purl.uniprot.org/uniprot/W5PMF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9940:NRBP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9T5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLDN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3CXR7|||http://purl.uniprot.org/uniprot/D6R6U0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||tight junction http://togogenome.org/gene/9940:SHOC2 ^@ http://purl.uniprot.org/uniprot/A0A6P3ER18|||http://purl.uniprot.org/uniprot/A0A6P3TFN2 ^@ Caution|||Function|||Similarity ^@ Belongs to the SHOC2 family.|||Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101102647 ^@ http://purl.uniprot.org/uniprot/W5QFE5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.|||Belongs to the 7B2 family.|||Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.|||Secreted http://togogenome.org/gene/9940:FNBP1L ^@ http://purl.uniprot.org/uniprot/A0A6P3DZ28|||http://purl.uniprot.org/uniprot/W5Q5W3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FNBP1 family.|||Cell membrane|||Cytoplasmic vesicle|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Vesicle|||cell cortex|||cytoskeleton http://togogenome.org/gene/9940:PLPPR5 ^@ http://purl.uniprot.org/uniprot/A0A6P3TCZ6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LBX2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7E8|||http://purl.uniprot.org/uniprot/W5PT61 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GTF2B ^@ http://purl.uniprot.org/uniprot/A0A6P3E6N3 ^@ Caution|||Similarity ^@ Belongs to the TFIIB family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NIF3L1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TMU8|||http://purl.uniprot.org/uniprot/W5Q595 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family.|||Cytoplasm|||Homodimer. Interacts with COPS2. Interacts with THOC7.|||May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.|||Nucleus http://togogenome.org/gene/9940:LRRFIP2 ^@ http://purl.uniprot.org/uniprot/W5Q4T0 ^@ Similarity ^@ Belongs to the LRRFIP family. http://togogenome.org/gene/9940:GPR171 ^@ http://purl.uniprot.org/uniprot/W5Q178 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9940:ITM2B ^@ http://purl.uniprot.org/uniprot/A0A6P9FQH2|||http://purl.uniprot.org/uniprot/B3VSB9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDCA2 ^@ http://purl.uniprot.org/uniprot/W5PJE5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:GPM6B ^@ http://purl.uniprot.org/uniprot/W5PPQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9940:LOC105615767 ^@ http://purl.uniprot.org/uniprot/A0A835ZMU2|||http://purl.uniprot.org/uniprot/W5Q7R3 ^@ Caution|||Subcellular Location Annotation ^@ Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RIBC1 ^@ http://purl.uniprot.org/uniprot/W5PF55 ^@ Similarity ^@ Belongs to the RIB43A family. http://togogenome.org/gene/9940:CD274 ^@ http://purl.uniprot.org/uniprot/A0A6P3E1B8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SOD1 ^@ http://purl.uniprot.org/uniprot/B9VGZ6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems.|||Nucleus http://togogenome.org/gene/9940:BMP4 ^@ http://purl.uniprot.org/uniprot/A8VTF8|||http://purl.uniprot.org/uniprot/W5QIU1 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9940:NPC2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6E8|||http://purl.uniprot.org/uniprot/A0A6P3TPJ2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NPC2 family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101109790 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3S9|||http://purl.uniprot.org/uniprot/W5Q9R0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STX4 ^@ http://purl.uniprot.org/uniprot/A0A6P3T5W3 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9940:GRIA3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TI04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9940:LOC105602384 ^@ http://purl.uniprot.org/uniprot/A0A836CV75 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101102314 ^@ http://purl.uniprot.org/uniprot/A0A836D3R9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101122667 ^@ http://purl.uniprot.org/uniprot/A0A6P7DQ21|||http://purl.uniprot.org/uniprot/J9UXY3 ^@ Caution|||Similarity ^@ Belongs to the GroES chaperonin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101113335 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9940:ARSJ ^@ http://purl.uniprot.org/uniprot/W5QA75 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9940:LOC101114379 ^@ http://purl.uniprot.org/uniprot/A0A836ABR5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101120701 ^@ http://purl.uniprot.org/uniprot/W5PM64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9940:MEIS1 ^@ http://purl.uniprot.org/uniprot/W5QFD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9940:PELI1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAV1|||http://purl.uniprot.org/uniprot/A0A6P3TAJ5 ^@ Caution|||Function|||Similarity ^@ Belongs to the pellino family.|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CD2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6Y0|||http://purl.uniprot.org/uniprot/W5QG93 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRNT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3T2Z6 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/9940:IFT122 ^@ http://purl.uniprot.org/uniprot/W5PYJ7 ^@ Subcellular Location Annotation ^@ cilium http://togogenome.org/gene/9940:LOC101111893 ^@ http://purl.uniprot.org/uniprot/W5P307 ^@ Similarity ^@ Belongs to the KRTAP type 3 family. http://togogenome.org/gene/9940:ELP6 ^@ http://purl.uniprot.org/uniprot/A0A6P3THN0|||http://purl.uniprot.org/uniprot/W5P050 ^@ Similarity ^@ Belongs to the ELP6 family. http://togogenome.org/gene/9940:GUCY1A1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TCV9|||http://purl.uniprot.org/uniprot/A0A6P7D151 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MIGA2 ^@ http://purl.uniprot.org/uniprot/W5PGD7 ^@ Similarity ^@ Belongs to the mitoguardin family. http://togogenome.org/gene/9940:LOC101120556 ^@ http://purl.uniprot.org/uniprot/A0A835ZKX6 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCDC90B ^@ http://purl.uniprot.org/uniprot/A0A835ZLP8|||http://purl.uniprot.org/uniprot/W5P5J9 ^@ Caution|||Similarity ^@ Belongs to the CCDC90 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC6A2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YQD6|||http://purl.uniprot.org/uniprot/W5Q9U1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:S100A5 ^@ http://purl.uniprot.org/uniprot/A0A6P3TJ05 ^@ Caution|||Similarity ^@ Belongs to the S-100 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GSTM3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TM19 ^@ Similarity ^@ Belongs to the GST superfamily. Mu family. http://togogenome.org/gene/9940:SPA17 ^@ http://purl.uniprot.org/uniprot/Q9TU08 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates. http://togogenome.org/gene/9940:TTC32 ^@ http://purl.uniprot.org/uniprot/A0A6P3E713 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CNST ^@ http://purl.uniprot.org/uniprot/A0A836CYD7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPP2R5E ^@ http://purl.uniprot.org/uniprot/A0A6P3E6C5|||http://purl.uniprot.org/uniprot/A0A6P3TUR0 ^@ Caution|||Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPF2 ^@ http://purl.uniprot.org/uniprot/W5Q1T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/9940:CHST10 ^@ http://purl.uniprot.org/uniprot/W5PUZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9940:GM2A ^@ http://purl.uniprot.org/uniprot/A0A836AHY7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RBKS ^@ http://purl.uniprot.org/uniprot/A0A6P3E270|||http://purl.uniprot.org/uniprot/W5QDU7 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Nucleus|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101114167 ^@ http://purl.uniprot.org/uniprot/W5P635 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPIN/STSY family.|||Nucleus http://togogenome.org/gene/9940:FOXP3 ^@ http://purl.uniprot.org/uniprot/B8Y745 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:CLSPN ^@ http://purl.uniprot.org/uniprot/W5QE43 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:LOC101102101 ^@ http://purl.uniprot.org/uniprot/W5Q169 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:ZGPAT ^@ http://purl.uniprot.org/uniprot/A0A836D031|||http://purl.uniprot.org/uniprot/C5IJB0 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with CHD4/Mi-2; the interaction is direct.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity). http://togogenome.org/gene/9940:BSND ^@ http://purl.uniprot.org/uniprot/A0A6P3E405 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAM98C ^@ http://purl.uniprot.org/uniprot/W5P6J6 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/9940:DCTPP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE82|||http://purl.uniprot.org/uniprot/W5P8H4 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Homotetramer.|||Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytosol http://togogenome.org/gene/9940:LOC101116777 ^@ http://purl.uniprot.org/uniprot/A0A6P7E9I3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase D subunit family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cilium|||clathrin-coated vesicle membrane http://togogenome.org/gene/9940:LOC101107296 ^@ http://purl.uniprot.org/uniprot/W5P1T6 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:CASQ2 ^@ http://purl.uniprot.org/uniprot/W5QG04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/9940:LALBA ^@ http://purl.uniprot.org/uniprot/P09462 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the glycosyl hydrolase 22 family.|||Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).|||Mammary gland specific. Secreted in milk.|||Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.|||Secreted http://togogenome.org/gene/9940:LOC101116002 ^@ http://purl.uniprot.org/uniprot/W5PZL3 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/9940:TMPRSS11A ^@ http://purl.uniprot.org/uniprot/A0A6P3TPW8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SFRP4 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECZ5|||http://purl.uniprot.org/uniprot/W5PGJ0 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TM2D3 ^@ http://purl.uniprot.org/uniprot/A0A6P3T2F3|||http://purl.uniprot.org/uniprot/W5Q526 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DNAJC2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8U1 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytosol http://togogenome.org/gene/9940:CALCRL ^@ http://purl.uniprot.org/uniprot/W5Q4Y4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.|||Membrane|||Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/9940:ADIPOR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3CYJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9940:FUNDC1 ^@ http://purl.uniprot.org/uniprot/W5P0D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9940:TFAP2A ^@ http://purl.uniprot.org/uniprot/Q9N0N3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AP-2 family.|||Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with RALBP1 in a complex also containing EPN1 and NUMB during interphase and mitosis. Interacts with KCTD1; this interaction represses transcription activation. Interacts (via C-terminus) with CITED2 (via C-terminus); the interaction stimulates TFAP2A-transcriptional activation. Interacts (via N-terminus) with EP300 (via N-terminus); the interaction requires CITED2 (By similarity). Interacts with KCTD15; this interaction inhibits TFAP2A transcriptional activation (By similarity).|||Nucleus|||Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region (By similarity).|||The PPxY motif mediates interaction with WWOX. http://togogenome.org/gene/9940:ACOD1 ^@ http://purl.uniprot.org/uniprot/W5Q396 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/9940:DZIP3 ^@ http://purl.uniprot.org/uniprot/W5QCG8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9940:LOC101112404 ^@ http://purl.uniprot.org/uniprot/A0A097IYE5 ^@ Similarity ^@ Belongs to the KRTAP type 3 family. http://togogenome.org/gene/9940:ACBD6 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJV4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IQCG ^@ http://purl.uniprot.org/uniprot/W5QGB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC9 family.|||flagellum|||flagellum axoneme http://togogenome.org/gene/9940:FAM183A ^@ http://purl.uniprot.org/uniprot/A0A6P3E672 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101106021 ^@ http://purl.uniprot.org/uniprot/W5NZL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAM33 family.|||Cell membrane http://togogenome.org/gene/9940:L3MBTL3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TPZ3|||http://purl.uniprot.org/uniprot/A0A6P3TRL8 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HS2ST1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5B6|||http://purl.uniprot.org/uniprot/W5PZV5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ACTL7B ^@ http://purl.uniprot.org/uniprot/W5NYG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||cytoskeleton http://togogenome.org/gene/9940:NLRP3 ^@ http://purl.uniprot.org/uniprot/A0A836AGY9|||http://purl.uniprot.org/uniprot/W5PCI1 ^@ Caution|||Similarity ^@ Belongs to the NLRP family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PAQR8 ^@ http://purl.uniprot.org/uniprot/A0A6P3T3S0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TNFSF4 ^@ http://purl.uniprot.org/uniprot/W5PZ67 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9940:CPXM1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EKH6|||http://purl.uniprot.org/uniprot/W5P6M9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101104027 ^@ http://purl.uniprot.org/uniprot/Q28580 ^@ Function|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the KRTAP type 7 family.|||In the wool cortex, wool keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant wool shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of wool keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with wool keratins.|||Wool. http://togogenome.org/gene/9940:TRAM1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E782|||http://purl.uniprot.org/uniprot/W5P1B6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SMU1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7Y2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SMU1 family.|||Nucleus speckle|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMSB4X ^@ http://purl.uniprot.org/uniprot/A0A6P3TKJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9940:PARK7 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8Q6|||http://purl.uniprot.org/uniprot/W5PK66 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C56 family.|||Membrane raft|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RAMP2 ^@ http://purl.uniprot.org/uniprot/W5NZT5 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/9940:SLC2A2 ^@ http://purl.uniprot.org/uniprot/W5QHW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:LOC101107295 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHJ3|||http://purl.uniprot.org/uniprot/W5P212 ^@ Caution|||Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DARS1 ^@ http://purl.uniprot.org/uniprot/C5IWV2 ^@ Function|||Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. http://togogenome.org/gene/9940:SLC35F2 ^@ http://purl.uniprot.org/uniprot/A0A6P3ELX3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLRN3 ^@ http://purl.uniprot.org/uniprot/W5PXA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9940:POLR2G ^@ http://purl.uniprot.org/uniprot/B7TJ05 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.|||Nucleus http://togogenome.org/gene/9940:DPY30 ^@ http://purl.uniprot.org/uniprot/A0A836AI52 ^@ Caution|||Similarity ^@ Belongs to the dpy-30 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AMER1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ERV9|||http://purl.uniprot.org/uniprot/W5P5V4 ^@ Caution|||Similarity ^@ Belongs to the Amer family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CEP19 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7Z3|||http://purl.uniprot.org/uniprot/A0A6P3T5K7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP19 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||centriole|||cilium basal body|||spindle pole http://togogenome.org/gene/9940:TBX15 ^@ http://purl.uniprot.org/uniprot/W5QGN3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9940:PXYLP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E764 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101112672 ^@ http://purl.uniprot.org/uniprot/W5PCI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:LOC101103623 ^@ http://purl.uniprot.org/uniprot/W5PFW8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.|||Monomer.|||Secreted http://togogenome.org/gene/9940:RNASE12 ^@ http://purl.uniprot.org/uniprot/W5QEN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9940:HAGH ^@ http://purl.uniprot.org/uniprot/A0A6P3EE16|||http://purl.uniprot.org/uniprot/W5Q540 ^@ Caution|||Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101113616 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJT8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Ena/VASP family.|||Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytoskeleton http://togogenome.org/gene/9940:XPO5 ^@ http://purl.uniprot.org/uniprot/W5PCK3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9940:PABPC4 ^@ http://purl.uniprot.org/uniprot/A0A6P7E143 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/9940:HARBI1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EMM5|||http://purl.uniprot.org/uniprot/A0A6P3TFQ6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HARBI1 family.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity. http://togogenome.org/gene/9940:UPB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EMG9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101102142 ^@ http://purl.uniprot.org/uniprot/W5NU82 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9940:H2AZ1 ^@ http://purl.uniprot.org/uniprot/A0A836A1Q6|||http://purl.uniprot.org/uniprot/Q6YNC8 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated on Lys-5, Lys-8, Lys-12 and Lys-14 by KAT2A; KAT2A is recruited by the XPC complex in absence of DNA damage (By similarity). Acetylated on Lys-5, Lys-8 and Lys-12 during interphase; acetylation disappears at mitosis (By similarity). Acetylation by the NuA4 histone acetyltransferase complex is required for hematopoietic stem cell maintenance (By similarity).|||Belongs to the histone H2A family.|||Chromosome|||Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.|||Monomethylated on Lys-5 and Lys-8 by SETD6. SETD6 predominantly methylates Lys-8, lys-5 being a possible secondary site.|||Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.|||Not phosphorylated.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AZ1 forms a heterodimer with H2B. H2AZ1 interacts with INCENP. Interacts (via M6 cassette) with ANP32E; leading to removal of H2A.Z/H2AZ1 from the nucleosome. Interacts with VPS72 (via N-terminal domain); the interaction is enhanced by VPS72 phosphorylation which is promoted by ZNHIT1. Interacts with PWWP2A. Interacts with FH (when phosphorylated by PRKDC). Interacts with ZNHIT1; the interaction results in recruitment of H2AZ1 to the MYOG promoter region which is required for muscle-specific gene expression (By similarity).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity). http://togogenome.org/gene/9940:BMT2 ^@ http://purl.uniprot.org/uniprot/W5NVA5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the BMT2 family.|||Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.|||S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9940:IFNT5 ^@ http://purl.uniprot.org/uniprot/Q28595 ^@ Developmental Stage|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.|||Constitutively and exclusively expressed in the mononuclear cells of the extraembryonic trophectoderm.|||IFN-tau genes are intronless. They evolved from IFN-omega genes in the ruminantia suborder and have continued to duplicate independently in different lineages of the ruminantia. They code for proteins very similar in sequence but with different biological potency and pattern of expression.|||Major secretory product synthesized by the sheep conceptus between days 13 and 21 of pregnancy.|||Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.|||Secreted http://togogenome.org/gene/9940:LOC101120345 ^@ http://purl.uniprot.org/uniprot/A0A6P3TIH5 ^@ Caution|||Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NIP7 ^@ http://purl.uniprot.org/uniprot/W5P046 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NIP7 family.|||Interacts with pre-ribosome complex.|||Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/9940:LOC101116438 ^@ http://purl.uniprot.org/uniprot/A0A835ZLV4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPP2R5C ^@ http://purl.uniprot.org/uniprot/W5NWN4 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9940:MECOM ^@ http://purl.uniprot.org/uniprot/A0A836AFK1 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RBM18 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6Z8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AKR1D1 ^@ http://purl.uniprot.org/uniprot/W5PK05 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9940:RBBP7 ^@ http://purl.uniprot.org/uniprot/A0A6P3YQ28 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UBE2L3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YRR0 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9940:PGK2 ^@ http://purl.uniprot.org/uniprot/W5PG09 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/9940:PIGW ^@ http://purl.uniprot.org/uniprot/A0A6P3ECU4|||http://purl.uniprot.org/uniprot/A0A6P3TSS0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGW family.|||Endoplasmic reticulum membrane|||Membrane|||Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101119640 ^@ http://purl.uniprot.org/uniprot/A0A6P3YIF3|||http://purl.uniprot.org/uniprot/W5PJ26 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PHOSPHO2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TMJ8 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/9940:ELF1 ^@ http://purl.uniprot.org/uniprot/W5PA85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9940:SLC25A44 ^@ http://purl.uniprot.org/uniprot/A0A6P3TRQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9940:PDZD11 ^@ http://purl.uniprot.org/uniprot/A0A6P3ESH4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPL23 ^@ http://purl.uniprot.org/uniprot/A0A6P3TI59|||http://purl.uniprot.org/uniprot/A0A6P7EGQ2 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PIGF ^@ http://purl.uniprot.org/uniprot/A0A6P3CY21|||http://purl.uniprot.org/uniprot/K4P443 ^@ Caution|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MAS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TVE4|||http://purl.uniprot.org/uniprot/W5NXQ6 ^@ Caution|||Similarity ^@ Belongs to the G-protein coupled receptor 1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RICTOR ^@ http://purl.uniprot.org/uniprot/A0A6P3EDQ2|||http://purl.uniprot.org/uniprot/W5PIY2 ^@ Caution|||Similarity ^@ Belongs to the RICTOR family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ABHD5 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQC8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FOXO4 ^@ http://purl.uniprot.org/uniprot/W5Q3G2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:RBM5 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECA8|||http://purl.uniprot.org/uniprot/W5PMN8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RBM5/RBM10 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ST6GAL1 ^@ http://purl.uniprot.org/uniprot/H9NAU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9940:MARCHF5 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDK4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MPDU1 ^@ http://purl.uniprot.org/uniprot/W5PZH6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPDU1 (TC 2.A.43.3) family.|||Membrane|||Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors. http://togogenome.org/gene/9940:ARF5 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQH5|||http://purl.uniprot.org/uniprot/C5IWS9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RAB6A ^@ http://purl.uniprot.org/uniprot/A0A6P3EMG4|||http://purl.uniprot.org/uniprot/A0A836D4I9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EMP3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFT7|||http://purl.uniprot.org/uniprot/A0A6P3TZH5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Probably involved in cell proliferation and cell-cell interactions.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CORT ^@ http://purl.uniprot.org/uniprot/B8Y4A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/9940:SPATA24 ^@ http://purl.uniprot.org/uniprot/A0A836AFT9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MORF4L2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFC6|||http://purl.uniprot.org/uniprot/A0A6P3EHK7 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the MSIN3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with MRFAP1 and RB1. May also interact with one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDK19 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFS8|||http://purl.uniprot.org/uniprot/W5PJS1 ^@ Caution|||Similarity ^@ Belongs to the protein kinase superfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KPNA2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDR3 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9940:TSHR ^@ http://purl.uniprot.org/uniprot/P56495 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Basolateral cell membrane|||Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||Glycosylated.|||Interacts with heterodimer GPHA2:GPHB5; this interaction stimulates cAMP production. Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function.|||Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.|||Sulfated. Sulfation on Tyr-385 plays a role in thyrotropin receptor binding and activation. http://togogenome.org/gene/9940:LOC101111435 ^@ http://purl.uniprot.org/uniprot/W5PLF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.|||Secreted http://togogenome.org/gene/9940:LOC101108324 ^@ http://purl.uniprot.org/uniprot/W5P204 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:GBE1 ^@ http://purl.uniprot.org/uniprot/W5Q5V0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. http://togogenome.org/gene/9940:LOC101120447 ^@ http://purl.uniprot.org/uniprot/W5QFN5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9940:COG6 ^@ http://purl.uniprot.org/uniprot/A0A836ABC7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COG6 family.|||Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.|||Golgi apparatus membrane|||Membrane|||Required for normal Golgi function.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STK17B ^@ http://purl.uniprot.org/uniprot/W5PZD3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9940:FAM168A ^@ http://purl.uniprot.org/uniprot/W5PD37 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/9940:COMMD10 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4N0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TTC21B ^@ http://purl.uniprot.org/uniprot/A0A836D5W5|||http://purl.uniprot.org/uniprot/W5P4N3 ^@ Caution|||Similarity ^@ Belongs to the TTC21 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TUBB ^@ http://purl.uniprot.org/uniprot/W5PPT6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9940:LRRC59 ^@ http://purl.uniprot.org/uniprot/A0A6P3EA66 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SEC24D ^@ http://purl.uniprot.org/uniprot/W5Q678 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9940:CTDSP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAP7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NPC1L1 ^@ http://purl.uniprot.org/uniprot/W5Q1M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/9940:WNT10B ^@ http://purl.uniprot.org/uniprot/W5NXT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9940:HMBS ^@ http://purl.uniprot.org/uniprot/A0A6P3EG84|||http://purl.uniprot.org/uniprot/W5PTY1 ^@ Caution|||Similarity ^@ Belongs to the HMBS family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRPF40A ^@ http://purl.uniprot.org/uniprot/A0A6P3E1S2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PAIP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4S9|||http://purl.uniprot.org/uniprot/W5Q6C6 ^@ Caution|||Similarity ^@ Belongs to the PAIP2 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GMEB1 ^@ http://purl.uniprot.org/uniprot/A0A6P7DR99 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KEF53_p04 ^@ http://purl.uniprot.org/uniprot/O78755|||http://purl.uniprot.org/uniprot/Q5MA68 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9940:COQ10B ^@ http://purl.uniprot.org/uniprot/W5Q1J7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/9940:PEBP4 ^@ http://purl.uniprot.org/uniprot/A0A836AL70 ^@ Caution|||Similarity ^@ Belongs to the phosphatidylethanolamine-binding protein family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TTLL9 ^@ http://purl.uniprot.org/uniprot/W5NVR4 ^@ Similarity ^@ Belongs to the tubulin--tyrosine ligase family. http://togogenome.org/gene/9940:LOC105607240 ^@ http://purl.uniprot.org/uniprot/W5QCN5 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/9940:UCP1 ^@ http://purl.uniprot.org/uniprot/G9I8W4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||May undergo ubiquitin-mediated proteasomal degradation.|||Membrane|||Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.|||Mitochondrion inner membrane http://togogenome.org/gene/9940:CTNS ^@ http://purl.uniprot.org/uniprot/W5Q7A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystinosin family.|||Membrane http://togogenome.org/gene/9940:TIMM8B ^@ http://purl.uniprot.org/uniprot/A0A6P3ECS0|||http://purl.uniprot.org/uniprot/W5Q3M6 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9940:POMC ^@ http://purl.uniprot.org/uniprot/P01191 ^@ Function|||Induction|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ ACTH and MSH are produced by the pituitary gland.|||Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.|||Belongs to the POMC family.|||Endogenous opiate.|||Endogenous orexigenic opiate.|||Increases the pigmentation of skin by increasing melanin production in melanocytes.|||Repressed by treatment with estradiol.|||Secreted|||Specific enzymatic cleavages at paired basic residues yield the different active peptides.|||Stimulates the adrenal glands to release cortisol. http://togogenome.org/gene/9940:ATOX1 ^@ http://purl.uniprot.org/uniprot/Q9XT28 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the ATX1 family.|||Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity).|||Interacts with ATP7B (By similarity). Interacts with ATP7A (By similarity).|||The heavy-metal-associated domain (HMA) coordinates a Cu(+) ion via the cysteine residues within the CXXC motif. The transfer of Cu(+) ion from ATOX1 to ATP7A involves the formation of a three-coordinate Cu(+)-bridged heterodimer where the metal is shared between the two metal binding sites of ATOX1 and ATP7A. The Cu(+) ion appears to switch between two coordination modes, forming two links with one protein and one with the other. Cisplatin, a chemotherapeutic drug, can bind the CXXC motif and hinder the release of Cu(+) ion. http://togogenome.org/gene/9940:MTCP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TB53|||http://purl.uniprot.org/uniprot/W5P008 ^@ Caution|||Similarity ^@ Belongs to the TCL1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PDCL3 ^@ http://purl.uniprot.org/uniprot/W5PUW9 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9940:DIS3 ^@ http://purl.uniprot.org/uniprot/W5Q139 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/9940:INTS14 ^@ http://purl.uniprot.org/uniprot/A0A836A8R2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INTS14 family.|||Nucleus|||Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NETO1 ^@ http://purl.uniprot.org/uniprot/W5P3Y1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:LAMC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBB2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||basement membrane http://togogenome.org/gene/9940:PNPLA8 ^@ http://purl.uniprot.org/uniprot/A0A6P3E423 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LEPROT ^@ http://purl.uniprot.org/uniprot/A0A6P3E6F2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LYN ^@ http://purl.uniprot.org/uniprot/A0A6P3YJC8|||http://purl.uniprot.org/uniprot/A0A6P9FQJ8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDKL1 ^@ http://purl.uniprot.org/uniprot/W5QHI5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9940:LOC101115527 ^@ http://purl.uniprot.org/uniprot/A0A6P3E2V5|||http://purl.uniprot.org/uniprot/W5PXS5 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:REEP6 ^@ http://purl.uniprot.org/uniprot/W5PR68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/9940:OSTF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E0U9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PACSIN1 ^@ http://purl.uniprot.org/uniprot/A0A835ZNR5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PACSIN family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytosol|||ruffle membrane|||synaptosome http://togogenome.org/gene/9940:PLPP1 ^@ http://purl.uniprot.org/uniprot/W5PCW9 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the PA-phosphatase related phosphoesterase family.|||Cell membrane|||Membrane|||Membrane raft|||caveola http://togogenome.org/gene/9940:LOXL3 ^@ http://purl.uniprot.org/uniprot/W5PTF1 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9940:RPIA ^@ http://purl.uniprot.org/uniprot/W5QHY6 ^@ Similarity ^@ Belongs to the ribose 5-phosphate isomerase family. http://togogenome.org/gene/9940:PPCS ^@ http://purl.uniprot.org/uniprot/B2LU23 ^@ Similarity ^@ Belongs to the PPC synthetase family. http://togogenome.org/gene/9940:LOC101103376 ^@ http://purl.uniprot.org/uniprot/W5PFU2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.|||Monomer.|||Secreted http://togogenome.org/gene/9940:CROT ^@ http://purl.uniprot.org/uniprot/W5PX72 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9940:AHSG ^@ http://purl.uniprot.org/uniprot/P29701 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fetuin family.|||Phosphorylated by FAM20C in the extracellular medium.|||Secreted http://togogenome.org/gene/9940:EYA3 ^@ http://purl.uniprot.org/uniprot/A0A6P3CWU4|||http://purl.uniprot.org/uniprot/C5HK62 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9940:UGT1A4 ^@ http://purl.uniprot.org/uniprot/F1CGV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9940:KRT222 ^@ http://purl.uniprot.org/uniprot/W5PZK5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9940:EML6 ^@ http://purl.uniprot.org/uniprot/W5NYX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat EMAP family.|||May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.|||cytoskeleton http://togogenome.org/gene/9940:S100A14 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENL8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC9A3R1 ^@ http://purl.uniprot.org/uniprot/A0A836A4A2|||http://purl.uniprot.org/uniprot/W5PRP1 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Endomembrane system|||Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||filopodium|||microvillus|||ruffle http://togogenome.org/gene/9940:PCGF5 ^@ http://purl.uniprot.org/uniprot/A0A6P3TFE4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:APOOL ^@ http://purl.uniprot.org/uniprot/A0A6P3EF61|||http://purl.uniprot.org/uniprot/W5NVI6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:VPS29 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHV4|||http://purl.uniprot.org/uniprot/W5Q644 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.|||Belongs to the VPS29 family.|||Endosome membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AGMAT ^@ http://purl.uniprot.org/uniprot/W5PHZ9 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/9940:LOC101122504 ^@ http://purl.uniprot.org/uniprot/W5NVP1 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9940:LOC101107442 ^@ http://purl.uniprot.org/uniprot/A0A6P3TNE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:FCF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBE2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP23/FCF1 family. FCF1 subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:KIAA1143 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEF8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TSN ^@ http://purl.uniprot.org/uniprot/A0A6P3E6G0|||http://purl.uniprot.org/uniprot/W5PV21 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the translin family.|||DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.|||Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.|||Nucleus|||Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POSTN ^@ http://purl.uniprot.org/uniprot/W5PK02|||http://purl.uniprot.org/uniprot/W5PK03 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9940:LOC101117235 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3D8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101120495 ^@ http://purl.uniprot.org/uniprot/W5NY83 ^@ Function|||Subcellular Location Annotation ^@ Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.|||Secreted http://togogenome.org/gene/9940:GPR141 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4S8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HABP4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAH8 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TPD52L2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YKV8 ^@ Caution|||Similarity ^@ Belongs to the TPD52 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPP1R21 ^@ http://purl.uniprot.org/uniprot/W5P3K4 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9940:LHB ^@ http://purl.uniprot.org/uniprot/P01231 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin. The beta chain can also be formed by LH beta 1, LH beta 2 and LH beta 3.|||Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The LH alpha 3/LH beta 3 heterodimer was shown to have potent renotropic and weak gonadotropic activity.|||Secreted http://togogenome.org/gene/9940:MRPL28 ^@ http://purl.uniprot.org/uniprot/A0A6P3ERD3 ^@ Caution|||Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NOTCH2 ^@ http://purl.uniprot.org/uniprot/W5QGV9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOTCH family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Nucleus http://togogenome.org/gene/9940:RBBP6 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQT2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KPNA5 ^@ http://purl.uniprot.org/uniprot/W5PGW2 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9940:GCG ^@ http://purl.uniprot.org/uniprot/A0A6P3TML5|||http://purl.uniprot.org/uniprot/W5P8Q7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/9940:CORO2B ^@ http://purl.uniprot.org/uniprot/W5QAZ1 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9940:TBC1D22B ^@ http://purl.uniprot.org/uniprot/A0A6P3ECH8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:REN ^@ http://purl.uniprot.org/uniprot/P52115 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the peptidase A1 family.|||Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.|||Interacts with ATP6AP2.|||Kidney.|||Membrane|||Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.|||Secreted http://togogenome.org/gene/9940:PHF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YNA0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDIP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9940:SERPINH1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FR52 ^@ Function|||Similarity ^@ Belongs to the serpin family.|||Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. http://togogenome.org/gene/9940:FOXJ3 ^@ http://purl.uniprot.org/uniprot/W5QGR2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:TFCP2L1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E1I1|||http://purl.uniprot.org/uniprot/W5PUC9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HINT2 ^@ http://purl.uniprot.org/uniprot/W5PQ45 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/9940:LSM10 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4T9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PGK1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FRD7|||http://purl.uniprot.org/uniprot/B7TJ13 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TM2D2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EML1|||http://purl.uniprot.org/uniprot/W5NUN2 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101120929 ^@ http://purl.uniprot.org/uniprot/W5P273 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:AIF1 ^@ http://purl.uniprot.org/uniprot/W5PDK4 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/9940:TSNAX ^@ http://purl.uniprot.org/uniprot/A0A6P3EED9|||http://purl.uniprot.org/uniprot/W5NZ92 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the translin family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TFE3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EH84|||http://purl.uniprot.org/uniprot/W5PND3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRPV2 ^@ http://purl.uniprot.org/uniprot/W5Q612 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:MAN2A1 ^@ http://purl.uniprot.org/uniprot/W5QC34 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9940:NR5A2 ^@ http://purl.uniprot.org/uniprot/G1FEX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/9940:TP63 ^@ http://purl.uniprot.org/uniprot/W5QGZ9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.|||Endoplasmic reticulum|||Mitochondrion matrix|||PML body|||centrosome http://togogenome.org/gene/9940:IL17B ^@ http://purl.uniprot.org/uniprot/W5P5J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9940:LOC101102969 ^@ http://purl.uniprot.org/uniprot/W5QGS8 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 22 family.|||Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. http://togogenome.org/gene/9940:HOXA10 ^@ http://purl.uniprot.org/uniprot/W5PIV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9940:LOC101122737 ^@ http://purl.uniprot.org/uniprot/A0A6P3DY62 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPL10A ^@ http://purl.uniprot.org/uniprot/A0A835ZUS5 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:APOH ^@ http://purl.uniprot.org/uniprot/W5Q268 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9940:LOC101104431 ^@ http://purl.uniprot.org/uniprot/W5PWK7 ^@ Similarity ^@ Belongs to the TAF11 family. http://togogenome.org/gene/9940:MB ^@ http://purl.uniprot.org/uniprot/A0A6P7DSP6|||http://purl.uniprot.org/uniprot/P02190 ^@ Caution|||Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NSUN4 ^@ http://purl.uniprot.org/uniprot/W5NWC8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9940:COL4A5 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENB1|||http://purl.uniprot.org/uniprot/W5Q9X9 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9940:TMEM182 ^@ http://purl.uniprot.org/uniprot/W5PU16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:MRRF ^@ http://purl.uniprot.org/uniprot/W5PXI9 ^@ Function|||Similarity ^@ Belongs to the RRF family.|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/9940:PRKAA2 ^@ http://purl.uniprot.org/uniprot/A8D245 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||Cytoplasm http://togogenome.org/gene/9940:TMEM14C ^@ http://purl.uniprot.org/uniprot/W5Q2W7 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9940:GPNMB ^@ http://purl.uniprot.org/uniprot/W5PT76 ^@ Similarity ^@ Belongs to the PMEL/NMB family. http://togogenome.org/gene/9940:FMR1 ^@ http://purl.uniprot.org/uniprot/W5PIV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMR1 family.|||Cell membrane|||Cytoplasmic ribonucleoprotein granule|||Membrane|||Perikaryon|||Presynaptic cell membrane|||Synaptic cell membrane|||axon|||centromere|||dendrite|||dendritic spine|||filopodium tip|||growth cone|||neuron projection|||nucleolus|||perinuclear region|||synaptosome http://togogenome.org/gene/9940:LYZL4 ^@ http://purl.uniprot.org/uniprot/F2X045 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9940:TCP11L1 ^@ http://purl.uniprot.org/uniprot/A0A6P3T5F3 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9940:DNAAF8 ^@ http://purl.uniprot.org/uniprot/A0A6P7DF52 ^@ Function ^@ In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits. http://togogenome.org/gene/9940:PDZK1IP1 ^@ http://purl.uniprot.org/uniprot/W5NZR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:PLD3 ^@ http://purl.uniprot.org/uniprot/A0A836A161|||http://purl.uniprot.org/uniprot/W5P9G8 ^@ Caution|||Similarity ^@ Belongs to the phospholipase D family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LRRC42 ^@ http://purl.uniprot.org/uniprot/W5P9W3 ^@ Similarity ^@ Belongs to the LRRC42 family. http://togogenome.org/gene/9940:A2ML1 ^@ http://purl.uniprot.org/uniprot/W5NUD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9940:ERCC6L ^@ http://purl.uniprot.org/uniprot/A0A835ZFW4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CRYAA ^@ http://purl.uniprot.org/uniprot/A0A836AQL0|||http://purl.uniprot.org/uniprot/Q5ENZ0 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-70 may increase chaperone activity.|||Belongs to the small heat shock protein (HSP20) family.|||Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.|||Cytoplasm|||Heteromer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and homotetramers (dimers of dimers) which serve as the building blocks of homooligomers (By similarity). Within homooligomers, the zinc-binding motif is created from residues of 3 different molecules. His-100 and Glu-102 from one molecule are ligands of the zinc ion, and His-107 and His-154 residues from additional molecules complete the site with tetrahedral coordination geometry (By similarity). Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA (By similarity).|||May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Undergoes age-dependent proteolytical cleavage at the C-terminus. http://togogenome.org/gene/9940:TXLNA ^@ http://purl.uniprot.org/uniprot/W5NQQ4 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9940:HSPA9 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4S6|||http://purl.uniprot.org/uniprot/W5Q4W8 ^@ Caution|||Similarity ^@ Belongs to the heat shock protein 70 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101105014 ^@ http://purl.uniprot.org/uniprot/A0A6P3YNF4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BTF3L4 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3Z1 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9940:IRAK4 ^@ http://purl.uniprot.org/uniprot/B7U176 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.|||Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Cytoplasm|||Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. http://togogenome.org/gene/9940:LOC101104225 ^@ http://purl.uniprot.org/uniprot/A0A6P3YIT3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CTNNB1 ^@ http://purl.uniprot.org/uniprot/M4WGF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||adherens junction http://togogenome.org/gene/9940:SNRPE ^@ http://purl.uniprot.org/uniprot/A0A6P3EAV5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytosol http://togogenome.org/gene/9940:MIEF2 ^@ http://purl.uniprot.org/uniprot/W5NQ74 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9940:RND1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TEL2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRPL44 ^@ http://purl.uniprot.org/uniprot/A0A836D7B1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.|||Mitochondrion|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101105540 ^@ http://purl.uniprot.org/uniprot/W5PFK2 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9940:LOC101114212 ^@ http://purl.uniprot.org/uniprot/W5P863 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:SNAPC5 ^@ http://purl.uniprot.org/uniprot/A0A6P3TNP2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101123349 ^@ http://purl.uniprot.org/uniprot/A0A6P3E105 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm|||podosome http://togogenome.org/gene/9940:PDHA1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEU7|||http://purl.uniprot.org/uniprot/W5PYS5 ^@ Caution|||Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLN3 ^@ http://purl.uniprot.org/uniprot/A0A6P3T5T4|||http://purl.uniprot.org/uniprot/A0A6P7DGL9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the battenin family.|||Lysosome membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MC2R ^@ http://purl.uniprot.org/uniprot/Q9TU77 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH) (By similarity).|||Receptor for corticotropin (ACTH). This receptor is mediated by G proteins which activate adenylate cyclase (cAMP). http://togogenome.org/gene/9940:C1QA ^@ http://purl.uniprot.org/uniprot/A0A6P3TNH6|||http://purl.uniprot.org/uniprot/W5PDS4 ^@ Function ^@ C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. http://togogenome.org/gene/9940:HACD3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TF92 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MTM1 ^@ http://purl.uniprot.org/uniprot/W5PGL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cell membrane|||Late endosome|||filopodium|||ruffle|||sarcomere http://togogenome.org/gene/9940:MYC ^@ http://purl.uniprot.org/uniprot/A0A836AC69|||http://purl.uniprot.org/uniprot/Q28566 ^@ Caution|||Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity). Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2. Interacts with RIOX1. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. Interacts with TRIM6 (By similarity). Interacts with NPM1; the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (By similarity). Interacts with CIP2A; leading to the stabilization of MYC (By similarity).|||Phosphorylated by PRKDC (By similarity). Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome. Dephosphorylation at Ser-62 by protein phosphatase 2A (PPP2CA) promotes its degradation; interaction with PPP2CA is enhanced by AMBRA1 (By similarity).|||The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity).|||Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform.|||Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. Ubiquitination is counteracted by USP28 in the nucleoplasm and USP36 in the nucleolus, both interacting with of FBXW7, leading to its deubiquitination and preventing degradation. Also polyubiquitinated by the DCX(TRPC4AP) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9940:DPP4 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8N0|||http://purl.uniprot.org/uniprot/W5P906 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the peptidase S9B family. DPPIV subfamily.|||Cell junction|||Cell membrane|||Membrane raft|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/9940:NT5C1A ^@ http://purl.uniprot.org/uniprot/A0A6P3DY36 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101123031 ^@ http://purl.uniprot.org/uniprot/W5NTD4 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9940:DAZAP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TEI1|||http://purl.uniprot.org/uniprot/W5Q7F0 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus speckle|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nuclear body http://togogenome.org/gene/9940:SCFD2 ^@ http://purl.uniprot.org/uniprot/W5QBH7 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9940:DRG1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBM6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KHK ^@ http://purl.uniprot.org/uniprot/A0A6P3E9S5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLK4 ^@ http://purl.uniprot.org/uniprot/W5Q2A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.|||Cleavage furrow|||centriole http://togogenome.org/gene/9940:HELLS ^@ http://purl.uniprot.org/uniprot/A0A6P3EKP1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TPM1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TI22|||http://purl.uniprot.org/uniprot/A0A6P9FRC8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytoskeleton http://togogenome.org/gene/9940:SLC25A53 ^@ http://purl.uniprot.org/uniprot/W5NR05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9940:SLC17A3 ^@ http://purl.uniprot.org/uniprot/W5NV35 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:NFATC3 ^@ http://purl.uniprot.org/uniprot/A0A836A1M7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPLP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFI8|||http://purl.uniprot.org/uniprot/W5QBE7 ^@ Caution|||Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101117112 ^@ http://purl.uniprot.org/uniprot/A0A6P3EEC7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PKIA ^@ http://purl.uniprot.org/uniprot/W5PCA8 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9940:HEATR3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EKZ4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GLT8D2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EC14 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:VPS16 ^@ http://purl.uniprot.org/uniprot/W5P5A7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS16 family.|||Early endosome|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.|||Vesicle http://togogenome.org/gene/9940:TIMP3 ^@ http://purl.uniprot.org/uniprot/A0A6P3CXN5|||http://purl.uniprot.org/uniprot/C8BKC2 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protease inhibitor I35 (TIMP) family.|||Interacts with EFEMP1.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||extracellular matrix http://togogenome.org/gene/9940:TFAP2D ^@ http://purl.uniprot.org/uniprot/W5PT23 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9940:CHST4 ^@ http://purl.uniprot.org/uniprot/W5PNC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9940:ATP6V1G3 ^@ http://purl.uniprot.org/uniprot/A0A836A030|||http://purl.uniprot.org/uniprot/W5Q1X7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9940:PDS5B ^@ http://purl.uniprot.org/uniprot/W5PMP0 ^@ Similarity ^@ Belongs to the PDS5 family. http://togogenome.org/gene/9940:PAG9 ^@ http://purl.uniprot.org/uniprot/O02729 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9940:RAB6B ^@ http://purl.uniprot.org/uniprot/A0A6P3E0I9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POLR3A ^@ http://purl.uniprot.org/uniprot/A0A835ZM08 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC6A13 ^@ http://purl.uniprot.org/uniprot/W5PQF4 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:SLC17A8 ^@ http://purl.uniprot.org/uniprot/W5PWE1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:SLC30A5 ^@ http://purl.uniprot.org/uniprot/W5P725 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Functions as a zinc transporter.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9940:DDX47 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECB4 ^@ Caution|||Similarity ^@ Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ADGRF2 ^@ http://purl.uniprot.org/uniprot/W5PQ63 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:SMAD6 ^@ http://purl.uniprot.org/uniprot/W5QA49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9940:ESCO1 ^@ http://purl.uniprot.org/uniprot/W5PF58 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:BMS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TA50 ^@ Caution|||Subcellular Location Annotation ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:PAG5 ^@ http://purl.uniprot.org/uniprot/O02725 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9940:KEF53_p05 ^@ http://purl.uniprot.org/uniprot/O78754|||http://purl.uniprot.org/uniprot/Q5MA69 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9940:LOC101106380 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDH9 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LIPG ^@ http://purl.uniprot.org/uniprot/A0A6P3T9I6|||http://purl.uniprot.org/uniprot/W5P1I2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9940:DNMT1 ^@ http://purl.uniprot.org/uniprot/Q865V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.|||Nucleus http://togogenome.org/gene/9940:RNASE2 ^@ http://purl.uniprot.org/uniprot/W5QEN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9940:LOC101116323 ^@ http://purl.uniprot.org/uniprot/A0A6P3E763|||http://purl.uniprot.org/uniprot/W5Q0T4 ^@ Caution|||Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RMND1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TRQ1 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/9940:GSTK1 ^@ http://purl.uniprot.org/uniprot/W5Q894 ^@ Similarity ^@ Belongs to the GST superfamily. Kappa family. http://togogenome.org/gene/9940:PSMA5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E480|||http://purl.uniprot.org/uniprot/W5QD30 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GRB14 ^@ http://purl.uniprot.org/uniprot/W5P757 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/9940:LOC100526782 ^@ http://purl.uniprot.org/uniprot/E3VW78 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9940:LOC101105081 ^@ http://purl.uniprot.org/uniprot/W5PXX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:BCKDK ^@ http://purl.uniprot.org/uniprot/A0A6P3ERN3|||http://purl.uniprot.org/uniprot/A0A6P3TJS6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GOLT1B ^@ http://purl.uniprot.org/uniprot/A0A6P3EB59 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATG9A ^@ http://purl.uniprot.org/uniprot/A0A6P3TI19 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/9940:BDH1 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZQ0|||http://purl.uniprot.org/uniprot/A0A836AEX2 ^@ Caution|||Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CENPN ^@ http://purl.uniprot.org/uniprot/W5PED9 ^@ Similarity ^@ Belongs to the CENP-N/CHL4 family. http://togogenome.org/gene/9940:FGF13 ^@ http://purl.uniprot.org/uniprot/A0A6P3EF81|||http://purl.uniprot.org/uniprot/W5PLX2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||dendrite|||filopodium|||growth cone|||sarcolemma http://togogenome.org/gene/9940:MTNR1B ^@ http://purl.uniprot.org/uniprot/A0A6P3CX01|||http://purl.uniprot.org/uniprot/B4YTT7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GABRA4 ^@ http://purl.uniprot.org/uniprot/W5Q1Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9940:INO80E ^@ http://purl.uniprot.org/uniprot/A0A6P3EQU8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMCO6 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECZ1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CXCL10 ^@ http://purl.uniprot.org/uniprot/A0A6P3CWG0|||http://purl.uniprot.org/uniprot/Q95MZ7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:VDAC2 ^@ http://purl.uniprot.org/uniprot/W5PG36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic mitochondrial porin family.|||Mitochondrion outer membrane http://togogenome.org/gene/9940:GOSR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EIA5|||http://purl.uniprot.org/uniprot/W5PMP6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GOSR1 family.|||Component of several multiprotein Golgi SNARE complexes.|||Golgi apparatus membrane|||Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101110185 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJI1|||http://purl.uniprot.org/uniprot/A0A836CTR2 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GSC ^@ http://purl.uniprot.org/uniprot/W5Q1C1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:GOT2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFE9|||http://purl.uniprot.org/uniprot/W5NUG0 ^@ Caution|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CD1D ^@ http://purl.uniprot.org/uniprot/O62848 ^@ Function|||Miscellaneous|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.|||Basolateral cell membrane|||Cell membrane|||During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.|||Endoplasmic reticulum membrane|||Endosome membrane|||Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.|||Heterodimer with B2M (beta-2-microglobulin). Interacts with MHC II and CD74 (By similarity).|||Lysosome membrane http://togogenome.org/gene/9940:RIMS3 ^@ http://purl.uniprot.org/uniprot/A0A6P3TL03 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C1R ^@ http://purl.uniprot.org/uniprot/A0A836AKC1 ^@ Caution|||Function|||Subunit ^@ C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.|||C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SELP ^@ http://purl.uniprot.org/uniprot/A0A835ZZD9|||http://purl.uniprot.org/uniprot/P98109 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the selectin/LECAM family.|||Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.|||Cell membrane|||Interacts with SNX17. Interacts with SELPLG/PSGL1 and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of SELPLG and PODXL2, and specific tyrosine sulfation on SELPLG.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NPY1R ^@ http://purl.uniprot.org/uniprot/A0A6P3TSX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:PNMA2 ^@ http://purl.uniprot.org/uniprot/W5PE65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PNMA family.|||nucleolus http://togogenome.org/gene/9940:KIAA0513 ^@ http://purl.uniprot.org/uniprot/A0A6P3TK17 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRAF3IP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBP7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SMC5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E198 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC5 subfamily.|||Chromosome|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLDN3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGH8|||http://purl.uniprot.org/uniprot/W5PMF3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the claudin family.|||Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||tight junction http://togogenome.org/gene/9940:LOC101106554 ^@ http://purl.uniprot.org/uniprot/W5Q443 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9940:GZMA ^@ http://purl.uniprot.org/uniprot/A0A835ZYS4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TAX1BP3 ^@ http://purl.uniprot.org/uniprot/W5Q7I8 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.|||Nucleus http://togogenome.org/gene/9940:LIN7C ^@ http://purl.uniprot.org/uniprot/A0A6P3EKU5|||http://purl.uniprot.org/uniprot/W5Q0E7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||tight junction http://togogenome.org/gene/9940:RUNX1T1 ^@ http://purl.uniprot.org/uniprot/A0A3S5HL72 ^@ Similarity ^@ Belongs to the CBFA2T family. http://togogenome.org/gene/9940:CCND2 ^@ http://purl.uniprot.org/uniprot/A0A6P3CX20|||http://purl.uniprot.org/uniprot/B2MVY2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin D subfamily.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:YPEL2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YNP6 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9940:ALKBH2 ^@ http://purl.uniprot.org/uniprot/A0A835ZRS5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GATA1 ^@ http://purl.uniprot.org/uniprot/F8WQV2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:LOC101102078 ^@ http://purl.uniprot.org/uniprot/W5QAX9 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9940:RBM7 ^@ http://purl.uniprot.org/uniprot/A0A6P3TF62 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ALDH8A1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8Q3|||http://purl.uniprot.org/uniprot/W5PZD2 ^@ Caution|||Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ETNPPL ^@ http://purl.uniprot.org/uniprot/A0A836D222|||http://purl.uniprot.org/uniprot/W5PCA1 ^@ Caution|||Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OCA2 ^@ http://purl.uniprot.org/uniprot/W5Q262 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:AGTR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3CWL5|||http://purl.uniprot.org/uniprot/Q9N0U1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101122747 ^@ http://purl.uniprot.org/uniprot/W5QHG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9940:LPO ^@ http://purl.uniprot.org/uniprot/A0A8N7XJI5 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasm|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101110447 ^@ http://purl.uniprot.org/uniprot/W5PQ78 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:FERD3L ^@ http://purl.uniprot.org/uniprot/A0A6P3TR49 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SNX7 ^@ http://purl.uniprot.org/uniprot/W5Q820 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9940:LOC101113096 ^@ http://purl.uniprot.org/uniprot/W5P9A9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:IL2 ^@ http://purl.uniprot.org/uniprot/P19114 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-2 family.|||Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.|||Secreted http://togogenome.org/gene/9940:TRIQK ^@ http://purl.uniprot.org/uniprot/A0A6P3TVT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIQK family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9940:THAP3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB67 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:WDR3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6Y6 ^@ Caution|||Subcellular Location Annotation ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:CSPP1 ^@ http://purl.uniprot.org/uniprot/A0A836A185 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRS2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJN4|||http://purl.uniprot.org/uniprot/W5PBP8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DLAT ^@ http://purl.uniprot.org/uniprot/W5Q2C5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 2 lipoyl cofactors covalently.|||Mitochondrion matrix|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/9940:ARAP2 ^@ http://purl.uniprot.org/uniprot/W5PHT4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9940:TMEM67 ^@ http://purl.uniprot.org/uniprot/A0A836ABU9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLAIN2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YIE1|||http://purl.uniprot.org/uniprot/W5Q6T7 ^@ Caution|||Similarity ^@ Belongs to the SLAIN motif-containing family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101114432 ^@ http://purl.uniprot.org/uniprot/A0A6P3TEW9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RXRG ^@ http://purl.uniprot.org/uniprot/A0A6P3TSV9|||http://purl.uniprot.org/uniprot/W5PP44 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Homodimer. Heterodimer; with a rar molecule.|||Nucleus|||Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. http://togogenome.org/gene/9940:SCNM1 ^@ http://purl.uniprot.org/uniprot/A0A6P3DYZ6|||http://purl.uniprot.org/uniprot/W5QIF0 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Nucleus speckle|||Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleoplasm http://togogenome.org/gene/9940:CTPS2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YPN8 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/9940:ERGIC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YN45|||http://purl.uniprot.org/uniprot/W5P1G5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101111629 ^@ http://purl.uniprot.org/uniprot/W5PT32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:SOD2 ^@ http://purl.uniprot.org/uniprot/A0A6P9FRH0|||http://purl.uniprot.org/uniprot/C8BKD6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems.|||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.|||Homotetramer.|||Mitochondrion matrix|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NPHP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E2M3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IFIH1 ^@ http://purl.uniprot.org/uniprot/W5P823 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9940:PIK3R1 ^@ http://purl.uniprot.org/uniprot/A0A835ZYC1 ^@ Caution|||Similarity ^@ Belongs to the PI3K p85 subunit family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101106323 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5M7|||http://purl.uniprot.org/uniprot/W5P8B9 ^@ Caution|||Similarity ^@ Belongs to the peptidase S14 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101118849 ^@ http://purl.uniprot.org/uniprot/W5NWG5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9940:PVALB ^@ http://purl.uniprot.org/uniprot/A0A6P3E3J6 ^@ Caution|||Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TWIST2 ^@ http://purl.uniprot.org/uniprot/A0A6P3DYJ2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MTO1 ^@ http://purl.uniprot.org/uniprot/W5P818 ^@ Function|||Similarity ^@ Belongs to the MnmG family.|||Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. http://togogenome.org/gene/9940:DLG1 ^@ http://purl.uniprot.org/uniprot/A0A6P7D2W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:MRPL34 ^@ http://purl.uniprot.org/uniprot/W5Q709 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/9940:RBP5 ^@ http://purl.uniprot.org/uniprot/A0A6P7DZS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm http://togogenome.org/gene/9940:PARP8 ^@ http://purl.uniprot.org/uniprot/W5PF05 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9940:FANCC ^@ http://purl.uniprot.org/uniprot/W5PFM1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70.|||DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.|||Nucleus http://togogenome.org/gene/9940:DCTN6 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGY1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytoskeleton http://togogenome.org/gene/9940:INPP1 ^@ http://purl.uniprot.org/uniprot/A0A6P7DPC6 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9940:TM4SF20 ^@ http://purl.uniprot.org/uniprot/A0A6P3E228|||http://purl.uniprot.org/uniprot/W5QH90 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ANXA11 ^@ http://purl.uniprot.org/uniprot/W5PJM4 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9940:GINS3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9L7|||http://purl.uniprot.org/uniprot/W5NTH9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS3/PSF3 family.|||Chromosome|||Component of the GINS complex.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101106894 ^@ http://purl.uniprot.org/uniprot/A0A835ZX15 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SPATA7 ^@ http://purl.uniprot.org/uniprot/A0A836D1Y3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EFNA3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E622|||http://purl.uniprot.org/uniprot/W5P072 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RNF145 ^@ http://purl.uniprot.org/uniprot/A0A6P3TMH9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:YARS1 ^@ http://purl.uniprot.org/uniprot/A0A836AGY1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DMAP1 ^@ http://purl.uniprot.org/uniprot/W5NRN7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:SAV1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EG01 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM231 ^@ http://purl.uniprot.org/uniprot/W5PA73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM231 family.|||Membrane|||Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.|||cilium membrane http://togogenome.org/gene/9940:NMNAT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE65 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9940:GDAP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4B2|||http://purl.uniprot.org/uniprot/W5QGH2 ^@ Caution|||Similarity ^@ Belongs to the GDAP2 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GID8 ^@ http://purl.uniprot.org/uniprot/A0A6P3EKJ2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATP6V1F ^@ http://purl.uniprot.org/uniprot/A0A6P3EC42|||http://purl.uniprot.org/uniprot/W5NZZ3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase F subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9940:CCT2 ^@ http://purl.uniprot.org/uniprot/W5QGG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9940:P2RY10 ^@ http://purl.uniprot.org/uniprot/A0A836CQF2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DNAJC22 ^@ http://purl.uniprot.org/uniprot/A0A6P3E339|||http://purl.uniprot.org/uniprot/W5QBU6 ^@ Caution|||Function|||Subcellular Location Annotation ^@ May function as a co-chaperone.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AHR ^@ http://purl.uniprot.org/uniprot/W5PHJ3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9940:SGTA ^@ http://purl.uniprot.org/uniprot/A0A6P3TGT9|||http://purl.uniprot.org/uniprot/A0A6P3TS61 ^@ Caution|||Similarity ^@ Belongs to the SGT family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLK1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ERK0 ^@ Caution|||Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101114017 ^@ http://purl.uniprot.org/uniprot/W5Q5P6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:LOC101117724 ^@ http://purl.uniprot.org/uniprot/W5PAU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:LOC101119515 ^@ http://purl.uniprot.org/uniprot/W5PGS1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:ATP6V0A1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TL70|||http://purl.uniprot.org/uniprot/W5NV03|||http://purl.uniprot.org/uniprot/W5NV06 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SERTAD1 ^@ http://purl.uniprot.org/uniprot/A0A836A3V8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ADRA1D ^@ http://purl.uniprot.org/uniprot/W5NPZ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.|||Membrane|||This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. http://togogenome.org/gene/9940:LOC101121762 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3V5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PTPN6 ^@ http://purl.uniprot.org/uniprot/A0A6P3TC87|||http://purl.uniprot.org/uniprot/W5P4P3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101110938 ^@ http://purl.uniprot.org/uniprot/A0A836D1P3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LMLN ^@ http://purl.uniprot.org/uniprot/W5QGA1 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M8 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9940:ANAPC7 ^@ http://purl.uniprot.org/uniprot/A0A6P3EM85 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLIP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YMB9|||http://purl.uniprot.org/uniprot/W5PNE4 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9940:FAM151B ^@ http://purl.uniprot.org/uniprot/W5PZI2 ^@ Similarity ^@ Belongs to the FAM151 family. http://togogenome.org/gene/9940:UBE2D4 ^@ http://purl.uniprot.org/uniprot/A0A6P3TDP8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9940:RPS19BP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3L2|||http://purl.uniprot.org/uniprot/W5Q5N4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AROS family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:USP4 ^@ http://purl.uniprot.org/uniprot/A0A836CSV2|||http://purl.uniprot.org/uniprot/W5PX00 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GSTA1 ^@ http://purl.uniprot.org/uniprot/B0LXN9 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9940:LRG1 ^@ http://purl.uniprot.org/uniprot/A0A836A8G3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EIF3E ^@ http://purl.uniprot.org/uniprot/W5PZH7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit E family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.|||Cytoplasm|||Nucleus|||PML body|||Phosphorylated upon DNA damage, probably by ATM or ATR. http://togogenome.org/gene/9940:LOC101115856 ^@ http://purl.uniprot.org/uniprot/W5PSY6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9940:LOC101110177 ^@ http://purl.uniprot.org/uniprot/W5PN49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9940:LOC101103491 ^@ http://purl.uniprot.org/uniprot/W5NWH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HOP2 family.|||Nucleus http://togogenome.org/gene/9940:AIPL1 ^@ http://purl.uniprot.org/uniprot/W5NVZ7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be important in protein trafficking and/or protein folding and stabilization.|||Nucleus http://togogenome.org/gene/9940:LOC101112585 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8P3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CAV1 ^@ http://purl.uniprot.org/uniprot/Q6B3Y2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity). Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner. Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation. Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (By similarity).|||May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).|||Membrane raft|||Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.|||Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation.|||caveola http://togogenome.org/gene/9940:CYLD ^@ http://purl.uniprot.org/uniprot/A0A6P3YQD0 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||centrosome|||cilium basal body|||perinuclear region|||spindle http://togogenome.org/gene/9940:BMPR1A ^@ http://purl.uniprot.org/uniprot/A0A6P3TJY5|||http://purl.uniprot.org/uniprot/A0A6P9FQW2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POLR2F ^@ http://purl.uniprot.org/uniprot/A0A6P3ECI5|||http://purl.uniprot.org/uniprot/W5PZ74 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ST8SIA1 ^@ http://purl.uniprot.org/uniprot/W5QG20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9940:NCALD ^@ http://purl.uniprot.org/uniprot/A0A6P3E970 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MTFP1 ^@ http://purl.uniprot.org/uniprot/A0A835ZQ77|||http://purl.uniprot.org/uniprot/W5PC75 ^@ Caution|||Similarity ^@ Belongs to the MTFP1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPIL4 ^@ http://purl.uniprot.org/uniprot/A0A836A8A9|||http://purl.uniprot.org/uniprot/W5NXE7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101123244 ^@ http://purl.uniprot.org/uniprot/W5NVY5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9940:GPBP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHC2|||http://purl.uniprot.org/uniprot/A0A835ZQL8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:YAE1 ^@ http://purl.uniprot.org/uniprot/W5Q8D5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9940:FAM180A ^@ http://purl.uniprot.org/uniprot/A0A6P3TN27 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STX16 ^@ http://purl.uniprot.org/uniprot/A0A6P3E987|||http://purl.uniprot.org/uniprot/A0A6P3TTF7 ^@ Caution|||Similarity ^@ Belongs to the syntaxin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARG2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6D5|||http://purl.uniprot.org/uniprot/W5QJ54 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SNCA ^@ http://purl.uniprot.org/uniprot/A0A6P3TPE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synuclein family.|||Membrane|||Nucleus|||Secreted|||Synapse|||axon http://togogenome.org/gene/9940:C15H11orf1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ELY4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LYRM4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EP55 ^@ Caution|||Similarity ^@ Belongs to the complex I LYR family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DCN ^@ http://purl.uniprot.org/uniprot/A0A6P3TDF7|||http://purl.uniprot.org/uniprot/Q9TTE2|||http://purl.uniprot.org/uniprot/W5Q2F5 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).|||Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT.|||May affect the rate of fibrils formation.|||The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||extracellular matrix http://togogenome.org/gene/9940:EBF2 ^@ http://purl.uniprot.org/uniprot/W5PJB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/9940:CDH10 ^@ http://purl.uniprot.org/uniprot/W5PT86 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:SUPT5H ^@ http://purl.uniprot.org/uniprot/W5P866 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT5 family.|||Nucleus http://togogenome.org/gene/9940:OPTN ^@ http://purl.uniprot.org/uniprot/A0A6P3TJ90 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Endosome|||Golgi apparatus|||May act by regulating membrane trafficking and cellular morphogenesis.|||Recycling endosome|||Vesicle|||autophagosome|||perinuclear region|||trans-Golgi network http://togogenome.org/gene/9940:LOC101112671 ^@ http://purl.uniprot.org/uniprot/A0A6P3EME1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:BMP5 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECG4|||http://purl.uniprot.org/uniprot/W5P8S3 ^@ Caution|||Similarity ^@ Belongs to the TGF-beta family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CRYGN ^@ http://purl.uniprot.org/uniprot/A0A6P3YL84 ^@ Caution|||Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CPN1 ^@ http://purl.uniprot.org/uniprot/W5PV54 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9940:PRMT5 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFL8|||http://purl.uniprot.org/uniprot/W5QDN6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).|||Belongs to the class I-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATP6V1E1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBD5|||http://purl.uniprot.org/uniprot/W5PVH8 ^@ Caution|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SHISAL2B ^@ http://purl.uniprot.org/uniprot/A0A6P3EHB2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SUPT20H ^@ http://purl.uniprot.org/uniprot/W5PKA8 ^@ Similarity ^@ Belongs to the SPT20 family. http://togogenome.org/gene/9940:LOC101112162 ^@ http://purl.uniprot.org/uniprot/W5P3N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 20 family.|||Lysosome http://togogenome.org/gene/9940:ELAVL2 ^@ http://purl.uniprot.org/uniprot/W5PYI5 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/9940:ADD3 ^@ http://purl.uniprot.org/uniprot/A0A6P3ER13 ^@ Caution|||Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101110974 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECW6 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HYAL1 ^@ http://purl.uniprot.org/uniprot/W5PIU5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9940:GPR50 ^@ http://purl.uniprot.org/uniprot/Q28558 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Does not bind melatonin.|||Homodimer, and heterodimer with MTNR1A and MTNR1B. http://togogenome.org/gene/9940:CA5B ^@ http://purl.uniprot.org/uniprot/W5PT28 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9940:CNTNAP1 ^@ http://purl.uniprot.org/uniprot/W5NYP3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||paranodal septate junction http://togogenome.org/gene/9940:GHRHR ^@ http://purl.uniprot.org/uniprot/Q9BDI0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:CTSH ^@ http://purl.uniprot.org/uniprot/W5PZ48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9940:TTR ^@ http://purl.uniprot.org/uniprot/A0A6P7DCR0|||http://purl.uniprot.org/uniprot/P12303 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the transthyretin family.|||Highly expressed in the choroid plexus.|||Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4 (By similarity).|||Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity).|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. http://togogenome.org/gene/9940:PSMA2 ^@ http://purl.uniprot.org/uniprot/W5Q7C7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9940:EIF3G ^@ http://purl.uniprot.org/uniprot/A0A6P3E5J0|||http://purl.uniprot.org/uniprot/W5Q0G0 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit G family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation.|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||perinuclear region http://togogenome.org/gene/9940:BABAM2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E738|||http://purl.uniprot.org/uniprot/A0A6P7DVI7 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BABAM2 family.|||Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.|||Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.|||Cytoplasm|||May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EXOC1 ^@ http://purl.uniprot.org/uniprot/W5NWG9|||http://purl.uniprot.org/uniprot/W5NWH2 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/9940:CHRNB4 ^@ http://purl.uniprot.org/uniprot/W5NST5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9940:FAM229A ^@ http://purl.uniprot.org/uniprot/W5QIF8 ^@ Similarity ^@ Belongs to the FAM229 family. http://togogenome.org/gene/9940:ITGB1BP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E701 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TADA2A ^@ http://purl.uniprot.org/uniprot/A0A6P3THP5|||http://purl.uniprot.org/uniprot/A0A6P3YJZ2 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LSM7 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4L6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LSM8 ^@ http://purl.uniprot.org/uniprot/W5Q9A3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. http://togogenome.org/gene/9940:HPDL ^@ http://purl.uniprot.org/uniprot/A0A6P3E3W0|||http://purl.uniprot.org/uniprot/W5PJH3 ^@ Caution|||Similarity ^@ Belongs to the 4HPPD family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GRIA1 ^@ http://purl.uniprot.org/uniprot/W5PI48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9940:NDUFC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDV0|||http://purl.uniprot.org/uniprot/A0A835ZSA6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFC1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:WDR48 ^@ http://purl.uniprot.org/uniprot/W5NUX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR48 family.|||Endosome|||Late endosome http://togogenome.org/gene/9940:KITLG ^@ http://purl.uniprot.org/uniprot/A0A836A7Q3|||http://purl.uniprot.org/uniprot/G8Z9W4|||http://purl.uniprot.org/uniprot/G8Z9W6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCF family.|||Cytoplasm|||Homodimer, non-covalently linked.|||Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||filopodium|||lamellipodium http://togogenome.org/gene/9940:LOC101117120 ^@ http://purl.uniprot.org/uniprot/A0A836A542|||http://purl.uniprot.org/uniprot/W5P2W9 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||Component of the 40S ribosomal subunit.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101119706 ^@ http://purl.uniprot.org/uniprot/A0A6P3E2G5|||http://purl.uniprot.org/uniprot/W5PH35 ^@ Caution|||Similarity ^@ Belongs to the cytochrome P450 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KRI1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDK9 ^@ Caution|||Similarity ^@ Belongs to the KRI1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SCAMP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EIA8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OSTC ^@ http://purl.uniprot.org/uniprot/A0A6P3EA62|||http://purl.uniprot.org/uniprot/W5PD29 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OSTC family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DOK4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFE5|||http://purl.uniprot.org/uniprot/W5NQ95 ^@ Caution|||Similarity ^@ Belongs to the DOK family. Type B subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RAB3C ^@ http://purl.uniprot.org/uniprot/A0A6P3T9Z4|||http://purl.uniprot.org/uniprot/W5PBD0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DDX50 ^@ http://purl.uniprot.org/uniprot/W5P5E9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. http://togogenome.org/gene/9940:PPP2CB ^@ http://purl.uniprot.org/uniprot/W5NPI8 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/9940:RO60 ^@ http://purl.uniprot.org/uniprot/W5PI89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ro 60 kDa family.|||Cytoplasm http://togogenome.org/gene/9940:HERPUD2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YKZ0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UBE2E2 ^@ http://purl.uniprot.org/uniprot/B3VSC4 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9940:ADD2 ^@ http://purl.uniprot.org/uniprot/W5PNH0 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/9940:HPGDS ^@ http://purl.uniprot.org/uniprot/A0A6P3E5C4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BCKDHA ^@ http://purl.uniprot.org/uniprot/A0A6P9FQE0|||http://purl.uniprot.org/uniprot/B2LSM3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the BCKDHA family.|||Heterotetramer of alpha and beta chains.|||The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:G3BP2 ^@ http://purl.uniprot.org/uniprot/A0A6P7E6Z8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LEAP2 ^@ http://purl.uniprot.org/uniprot/W5PUT7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LEAP2 family.|||Has an antimicrobial activity.|||Secreted http://togogenome.org/gene/9940:TNMD ^@ http://purl.uniprot.org/uniprot/W5NWC1 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/9940:DLST ^@ http://purl.uniprot.org/uniprot/W5NTS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9940:OSBPL9 ^@ http://purl.uniprot.org/uniprot/A0A6P3TCP2|||http://purl.uniprot.org/uniprot/W5P3W6 ^@ Caution|||Similarity ^@ Belongs to the OSBP family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDK2 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQI2|||http://purl.uniprot.org/uniprot/B7U171 ^@ Caution|||Similarity ^@ Belongs to the protein kinase superfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMEM218 ^@ http://purl.uniprot.org/uniprot/W5PNU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM218 family.|||May be involved in ciliary biogenesis or function.|||Membrane|||cilium http://togogenome.org/gene/9940:EXOSC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFR0|||http://purl.uniprot.org/uniprot/W5PKA0 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AIG1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EG26 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPP1R16B ^@ http://purl.uniprot.org/uniprot/A0A6P3EBY8|||http://purl.uniprot.org/uniprot/A0A6P7EP96 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HLF ^@ http://purl.uniprot.org/uniprot/A0A6P9FQH9|||http://purl.uniprot.org/uniprot/B6CM53 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CKM ^@ http://purl.uniprot.org/uniprot/A0A6P3TVY2|||http://purl.uniprot.org/uniprot/W5PJ69 ^@ Caution|||Similarity ^@ Belongs to the ATP:guanido phosphotransferase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCL26 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE98 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRPS18B ^@ http://purl.uniprot.org/uniprot/W5PSX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.|||Mitochondrion http://togogenome.org/gene/9940:LRRC23 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3H7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC24A4 ^@ http://purl.uniprot.org/uniprot/W5PTW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9940:THRA ^@ http://purl.uniprot.org/uniprot/Q28570 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with C1D. Interacts with AKAP13. Interacts with TP53INP2. Interacts with PER2 (By similarity). Interacts with TACC1. The interaction with isoform alpha-1, but not alpha-2, is decreased in the presence of thyroid hormone T3 (By similarity).|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Cytoplasm|||Does not bind thyroid hormone T3.|||Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.|||Nucleus http://togogenome.org/gene/9940:LOC101103041 ^@ http://purl.uniprot.org/uniprot/W5NY11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9940:OXGR1 ^@ http://purl.uniprot.org/uniprot/A0A836AAP8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATG3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6P2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RHOH ^@ http://purl.uniprot.org/uniprot/A0A6P3CX22 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PSMB7 ^@ http://purl.uniprot.org/uniprot/W5PVU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. http://togogenome.org/gene/9940:AFG1L ^@ http://purl.uniprot.org/uniprot/W5PM77 ^@ Similarity ^@ Belongs to the AFG1 ATPase family. http://togogenome.org/gene/9940:CYP2J ^@ http://purl.uniprot.org/uniprot/Q08ET7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9940:IL34 ^@ http://purl.uniprot.org/uniprot/A0A836A2M4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PDIA6 ^@ http://purl.uniprot.org/uniprot/A0A6P3YI89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen|||Melanosome http://togogenome.org/gene/9940:DDRGK1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E974 ^@ Caution|||Similarity ^@ Belongs to the DDRGK1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCDC115 ^@ http://purl.uniprot.org/uniprot/A0A6P7DNW4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC25A20 ^@ http://purl.uniprot.org/uniprot/B2MVX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9940:ASB8 ^@ http://purl.uniprot.org/uniprot/A0A6P3TBD0 ^@ Function ^@ May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9940:LIN28A ^@ http://purl.uniprot.org/uniprot/H6WP37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-28 family.|||nucleolus http://togogenome.org/gene/9940:UBE2F ^@ http://purl.uniprot.org/uniprot/A0A6P3YIJ2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9940:TMEM38B ^@ http://purl.uniprot.org/uniprot/W5PBF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/9940:ATP6V0E1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB04|||http://purl.uniprot.org/uniprot/W5P1K7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9940:NXF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EK42|||http://purl.uniprot.org/uniprot/W5Q7E7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NXF family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleoplasm http://togogenome.org/gene/9940:LOC101115480 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDA6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLS1 ^@ http://purl.uniprot.org/uniprot/A0A836AQG3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLIN5 ^@ http://purl.uniprot.org/uniprot/B0FJL7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the perilipin family.|||Cytoplasm|||Homooligomer. Interacts with PNPLA2; prevents interaction of PNPLA2 with ABHD5. Interacts with ABHD5; targets ABHD5 to lipid droplets and promotes interaction of ABHD5 with PNPLA2. Interacts with LIPE (By similarity).|||Lipid droplet|||Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity).|||Mitochondrion|||Phosphorylated by PKA. Phosphorylated on serine in skeletal muscle at rest or upon lipolytic stimulation (By similarity). http://togogenome.org/gene/9940:CYTL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAM2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MYD88 ^@ http://purl.uniprot.org/uniprot/C8BKC7 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).|||Cytoplasm|||Detecetd in mesenteric lymph node, prescapular lymph node, lymphocytes, lung, kidney, skin and urinary bladder.|||Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1. Interacts with BMX, IL1RL1, IKBKE and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. May interact with PIK3AP1. Interacts (via TIR domain) with DHX9 (via H2A and OB-fold regions); this interaction is direct. Interacts with OTUD4 deubiquitinase; the interaction is direct.|||Nucleus|||The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.|||Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88. http://togogenome.org/gene/9940:CA1 ^@ http://purl.uniprot.org/uniprot/P48282 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-carbonic anhydrase family.|||Catalyzes the reversible hydration of carbon dioxide.|||Cytoplasm|||Inhibited by acetazolamide. http://togogenome.org/gene/9940:BRMS1 ^@ http://purl.uniprot.org/uniprot/A0A6P7D8I5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:TAL2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YJ38 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PMS2 ^@ http://purl.uniprot.org/uniprot/A0A6P3ELY5 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/9940:DLX1 ^@ http://purl.uniprot.org/uniprot/W5NTM4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:CDKN1B ^@ http://purl.uniprot.org/uniprot/W5QI61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDI family.|||Cytoplasm|||Endosome|||Nucleus http://togogenome.org/gene/9940:PRXL2A ^@ http://purl.uniprot.org/uniprot/A0A6P7DHJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.|||Cytoplasm http://togogenome.org/gene/9940:GNG5 ^@ http://purl.uniprot.org/uniprot/A0A6P3YEX7|||http://purl.uniprot.org/uniprot/W5PWW2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRPF4 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8S1 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus speckle|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SNX2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YHY5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||lamellipodium http://togogenome.org/gene/9940:DDX6 ^@ http://purl.uniprot.org/uniprot/W5PPA7 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9940:S100B ^@ http://purl.uniprot.org/uniprot/A0A6P3E0L8|||http://purl.uniprot.org/uniprot/W5PVB6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. http://togogenome.org/gene/9940:CD180 ^@ http://purl.uniprot.org/uniprot/W5P7C7 ^@ Similarity ^@ Belongs to the Toll-like receptor family. http://togogenome.org/gene/9940:LOC101116076 ^@ http://purl.uniprot.org/uniprot/A0A6P3EF16 ^@ Caution|||Similarity ^@ Belongs to the CBP3 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BEGAIN ^@ http://purl.uniprot.org/uniprot/Q6R6L0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with DLG4 and DLGAP1 and forms a ternary complex.|||May sustain the structure of the postsynaptic density (PSD).|||Membrane http://togogenome.org/gene/9940:DTNBP1 ^@ http://purl.uniprot.org/uniprot/B2LU24 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/9940:TVP23B ^@ http://purl.uniprot.org/uniprot/A0A836CY07 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLA2G12A ^@ http://purl.uniprot.org/uniprot/W5P6I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/9940:LGALS12 ^@ http://purl.uniprot.org/uniprot/A0A836CRP2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SIRT3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQQ2|||http://purl.uniprot.org/uniprot/W5PGB0 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the sirtuin family. Class I subfamily.|||Binds 1 zinc ion per subunit.|||NAD-dependent protein deacetylase.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZDHHC7 ^@ http://purl.uniprot.org/uniprot/C7BDW1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9940:TSPAN9 ^@ http://purl.uniprot.org/uniprot/A0A836D5M8|||http://purl.uniprot.org/uniprot/B3VSC2 ^@ Caution|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tetraspanin (TM4SF) family.|||Found in a complex with GP6.|||Glycosylated.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101120236 ^@ http://purl.uniprot.org/uniprot/A0A6P7EG13|||http://purl.uniprot.org/uniprot/W5PD15 ^@ Caution|||Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/9940:NRM ^@ http://purl.uniprot.org/uniprot/W5PQR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nurim family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9940:ANKRD22 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFP3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ORC1 ^@ http://purl.uniprot.org/uniprot/W5P5G8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC1 family.|||Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Nucleus http://togogenome.org/gene/9940:ZBTB9 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECH1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101119853 ^@ http://purl.uniprot.org/uniprot/A0A6P3TDT2|||http://purl.uniprot.org/uniprot/W5PX83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9940:PDE1B ^@ http://purl.uniprot.org/uniprot/W5Q3K8 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9940:RFX6 ^@ http://purl.uniprot.org/uniprot/A0A836ACZ3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:INTS13 ^@ http://purl.uniprot.org/uniprot/A0A836ABB6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the asunder family.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TAGLN2 ^@ http://purl.uniprot.org/uniprot/A0A836DA07 ^@ Caution|||Similarity ^@ Belongs to the calponin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CMC2 ^@ http://purl.uniprot.org/uniprot/W5PE50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/9940:RPL29 ^@ http://purl.uniprot.org/uniprot/W5P900 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL29 family. http://togogenome.org/gene/9940:LOC101105617 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6L0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TTC27 ^@ http://purl.uniprot.org/uniprot/W5PL13 ^@ Similarity ^@ Belongs to the TTC27 family. http://togogenome.org/gene/9940:VNN1 ^@ http://purl.uniprot.org/uniprot/A0A6P7EAS8 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9940:C19H3orf14 ^@ http://purl.uniprot.org/uniprot/A0A6P3EPE2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RDH11 ^@ http://purl.uniprot.org/uniprot/A0A6P3TR50|||http://purl.uniprot.org/uniprot/W5QJ56 ^@ Caution|||Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SIRT4 ^@ http://purl.uniprot.org/uniprot/C5IWT2 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.|||Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.|||Belongs to the sirtuin family. Class II subfamily.|||Binds 1 zinc ion per subunit.|||Interacts with GLUD1, IDE and SLC25A5. Interacts with DLAT and PDHX.|||Mitochondrion matrix http://togogenome.org/gene/9940:DCLRE1A ^@ http://purl.uniprot.org/uniprot/W5PV68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9940:RAB38 ^@ http://purl.uniprot.org/uniprot/A0A6P3EF90 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9940:SLC25A13 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4H8|||http://purl.uniprot.org/uniprot/W5P1S3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATP7A ^@ http://purl.uniprot.org/uniprot/W5QAF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9940:ADAM9 ^@ http://purl.uniprot.org/uniprot/A0A6P3ES81|||http://purl.uniprot.org/uniprot/W5NUR4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCR10 ^@ http://purl.uniprot.org/uniprot/A0A6P3CWN4|||http://purl.uniprot.org/uniprot/Q1WLP8 ^@ Caution|||Similarity ^@ Belongs to the G-protein coupled receptor 1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ERP27 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3S1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SMAD5 ^@ http://purl.uniprot.org/uniprot/W5PZY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9940:MYO6 ^@ http://purl.uniprot.org/uniprot/W5P9P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||clathrin-coated pit|||clathrin-coated vesicle|||filopodium|||microvillus http://togogenome.org/gene/9940:TRMT10B ^@ http://purl.uniprot.org/uniprot/A0A6P3E819 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NPPA ^@ http://purl.uniprot.org/uniprot/O46540 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the natriuretic peptide family.|||Cell projection|||Cleavage by MME initiates degradation of the factor and thereby regulates its activity. Degradation by IDE results in reduced activation of NPR1 (in vitro). During IDE degradation, the resulting products can temporarily stimulate NPR2 to produce cGMP, before the fragments are completely degraded and inactivated by IDE (in vitro).|||Degraded by IDE.|||Homodimer; disulfide-linked antiparallel dimer.|||Hormone produced in the kidneys that appears to be important for maintaining cardio-renal homeostasis. Mediates vasodilation, natriuresis and diuresis primarily in the renal system, in order to maintain the extracellular fluid volume and control the fluid-electrolyte balance. Specifically binds and stimulates cGMP production by renal transmembrane receptors, likely NPR1. Urodilatin not ANP, may be the natriuretic peptide responsible for the regulation of sodium and water homeostasis in the kidney.|||Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses (By similarity). Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance (By similarity). Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts (By similarity). Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension (By similarity). In adipose tissue, acts in various cGMP- and PKG-dependent pathways to regulate lipid metabolism and energy homeostasis (By similarity). This includes up-regulating lipid metabolism and mitochondrial oxygen utilization by activating the AMP-activated protein kinase (AMPK), and increasing energy expenditure by acting via MAPK11 to promote the UCP1-dependent thermogenesis of brown adipose tissue (By similarity). Binds the clearance receptor NPR3 which removes the hormone from circulation (By similarity).|||May have a role in cardio-renal homeostasis through regulation of diuresis and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. May have a role in potassium excretion but not sodium excretion (natriuresis). Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, and vasodilation. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis. Appears to bind to specific receptors that are distinct from the receptors bound by the atrial natriuretic and long-acting natriuretic peptides. Possibly functions in protein excretion in urine by maintaining the integrity of the proximal tubules and enhancing protein excretion by decreasing proximal tubular protein reabsorption.|||May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, vasodilation, and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (By similarity). However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report, in vivo it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (By similarity). Appears to bind to specific receptors that are distinct from the receptors bound by atrial natriuretic peptide and vessel dilator. Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption (By similarity).|||May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.|||Perikaryon|||Phosphorylation on Ser-128 decreases vasorelaxant activity.|||Results concerning the involvement of this peptide in blood volume and blood pressure homeostasis are conflicting. Several studies utilising in vitro and heterologous expression systems show that it is able to activate cGMP and promote vasodilation and natriuresis (By similarity). However, a heterologous and in vivo expression study in rat found that it is not sufficient to induce any diuretic, natriuretic, nor hypotensive responses, and is unable to bind NPR1 nor increase guanylyl cyclase activity (By similarity).|||Results concerning the involvement of this peptide in blood volume and blood pressure homeostasis are conflicting. Several studies utilising in vitro and heterologous expression systems show that it is able to activate cGMP and promote vasodilation and natriuresis (By similarity). However, an in vivo study in rat found that it is not sufficient to induce any diuretic, natriuretic, nor hypotensive responses, and is unable to bind NPR1 nor increase guanylyl cyclase activity (By similarity).|||Secreted|||The precursor molecule is proteolytically cleaved by CORIN at Arg-122 to produce the atrial natriuretic peptide (By similarity). Undergoes further proteolytic cleavage by unknown proteases to give rise to long-acting natriuretic peptide, vessel dilator and kaliuretic peptide (By similarity). Additional processing gives rise to the auriculin and atriopeptin peptides (By similarity). In the kidneys, alternative processing by an unknown protease results in the peptide urodilatin (By similarity). http://togogenome.org/gene/9940:CNN1 ^@ http://purl.uniprot.org/uniprot/A0A836D2P7|||http://purl.uniprot.org/uniprot/Q7YRL2 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the calponin family.|||Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity).|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/9940:MOSPD2 ^@ http://purl.uniprot.org/uniprot/A0A6P3ES92 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CAMK1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EPC0|||http://purl.uniprot.org/uniprot/W5P841 ^@ Caution|||Similarity ^@ Belongs to the protein kinase superfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101109345 ^@ http://purl.uniprot.org/uniprot/W5PVL1 ^@ Function|||Similarity ^@ Belongs to the PET191 family.|||Involved in an early step of the mitochondrial complex IV assembly process. http://togogenome.org/gene/9940:UBQLN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3CWX8|||http://purl.uniprot.org/uniprot/C5ISB7 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||autophagosome http://togogenome.org/gene/9940:LOC101106199 ^@ http://purl.uniprot.org/uniprot/A0A835ZT30|||http://purl.uniprot.org/uniprot/P02083 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the globin family.|||Heterotetramer of two alpha chains and two beta chains.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AGPAT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TEE2|||http://purl.uniprot.org/uniprot/A0A6P7D766|||http://purl.uniprot.org/uniprot/Q95JH0 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||Endoplasmic reticulum membrane|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CACNB4 ^@ http://purl.uniprot.org/uniprot/W5PF31 ^@ Similarity ^@ Belongs to the calcium channel beta subunit family. http://togogenome.org/gene/9940:UBE2E3 ^@ http://purl.uniprot.org/uniprot/A0A835ZIM5 ^@ Caution|||Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FOS ^@ http://purl.uniprot.org/uniprot/A0A6P3CXM5|||http://purl.uniprot.org/uniprot/C8BKC1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Fos subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytosol http://togogenome.org/gene/9940:SMIM15 ^@ http://purl.uniprot.org/uniprot/W5P5S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM15 family.|||Membrane http://togogenome.org/gene/9940:LOC443456 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZB2|||http://purl.uniprot.org/uniprot/W5QET6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Cell membrane|||Membrane|||Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SC5 ^@ http://purl.uniprot.org/uniprot/P49929 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Broad spectrum bactericidal agent.|||Secreted http://togogenome.org/gene/9940:ITGA4 ^@ http://purl.uniprot.org/uniprot/W5Q5Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9940:CCS ^@ http://purl.uniprot.org/uniprot/W5PBW4 ^@ Similarity|||Subcellular Location Annotation ^@ In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.|||Nucleus http://togogenome.org/gene/9940:ITK ^@ http://purl.uniprot.org/uniprot/A0A6P3EEE1|||http://purl.uniprot.org/uniprot/W5PNG3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPS8 ^@ http://purl.uniprot.org/uniprot/A0A6P3CXM0|||http://purl.uniprot.org/uniprot/K4P1S8 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAM120C ^@ http://purl.uniprot.org/uniprot/A0A6P3ESD9|||http://purl.uniprot.org/uniprot/W5P9N6 ^@ Caution|||Similarity ^@ Belongs to the constitutive coactivator of PPAR-gamma family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPP2R2A ^@ http://purl.uniprot.org/uniprot/A0A6P3YFU3|||http://purl.uniprot.org/uniprot/A0A8K1PH10 ^@ Caution|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DYNC2LI1 ^@ http://purl.uniprot.org/uniprot/W5PA46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light intermediate chain family.|||centrosome|||cilium|||cilium axoneme|||cilium basal body http://togogenome.org/gene/9940:PDGFRA ^@ http://purl.uniprot.org/uniprot/W5QCN4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.|||Membrane|||Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.|||Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. http://togogenome.org/gene/9940:GCK ^@ http://purl.uniprot.org/uniprot/M1TCR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hexokinase family.|||Membrane|||Mitochondrion outer membrane|||cytosol http://togogenome.org/gene/9940:TM4SF5 ^@ http://purl.uniprot.org/uniprot/A0A6P3EH35|||http://purl.uniprot.org/uniprot/W5PB58 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MAP1LC3B ^@ http://purl.uniprot.org/uniprot/A0A6P3EJC5|||http://purl.uniprot.org/uniprot/W5PQI9 ^@ Caution|||Similarity ^@ Belongs to the ATG8 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC105614854 ^@ http://purl.uniprot.org/uniprot/A0A6P3TQP7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LHFPL4 ^@ http://purl.uniprot.org/uniprot/W5PA40 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:THNSL1 ^@ http://purl.uniprot.org/uniprot/A0A835ZUD3 ^@ Caution|||Similarity ^@ Belongs to the threonine synthase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STMN4 ^@ http://purl.uniprot.org/uniprot/W5PJ20 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9940:CNRIP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E2J1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SFXN4 ^@ http://purl.uniprot.org/uniprot/W5NU29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane http://togogenome.org/gene/9940:SSR2 ^@ http://purl.uniprot.org/uniprot/W5P572 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-beta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9940:CPLX3 ^@ http://purl.uniprot.org/uniprot/W5NYR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9940:OGFOD2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHT7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PSMD12 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHN2|||http://purl.uniprot.org/uniprot/W5Q2N2 ^@ Caution|||Similarity ^@ Belongs to the proteasome subunit p55 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SETD9 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENA4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GDPGP1 ^@ http://purl.uniprot.org/uniprot/W5Q7N8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GDPGP1 family.|||Cytoplasm|||Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells. http://togogenome.org/gene/9940:GSTA1-1 ^@ http://purl.uniprot.org/uniprot/W5PZE4 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9940:MME ^@ http://purl.uniprot.org/uniprot/A0A6P3T810|||http://purl.uniprot.org/uniprot/W5NZL3 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CPNE1 ^@ http://purl.uniprot.org/uniprot/C5ISA8 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9940:LOC101114857 ^@ http://purl.uniprot.org/uniprot/A0A6P3TQL5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ADIPOQ ^@ http://purl.uniprot.org/uniprot/A0A6P3CYL5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPF1 ^@ http://purl.uniprot.org/uniprot/A0A836AI62|||http://purl.uniprot.org/uniprot/W5PWN9 ^@ Caution|||Subcellular Location Annotation ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:LOC101117184 ^@ http://purl.uniprot.org/uniprot/P67982 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.|||Monomer. http://togogenome.org/gene/9940:IL6 ^@ http://purl.uniprot.org/uniprot/B7TXY8|||http://purl.uniprot.org/uniprot/P29455 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability. Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF. Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (By similarity). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis. Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (By similarity). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).|||Belongs to the IL-6 superfamily.|||Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST. Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling. Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation. May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling.|||Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.|||IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (By similarity). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity).|||IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (By similarity). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells.|||Secreted http://togogenome.org/gene/9940:RPTOR ^@ http://purl.uniprot.org/uniprot/A0A6P3EHP9|||http://purl.uniprot.org/uniprot/W5NQQ5 ^@ Caution|||Similarity ^@ Belongs to the WD repeat RAPTOR family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101116979 ^@ http://purl.uniprot.org/uniprot/W5QD87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:LOC101103421 ^@ http://purl.uniprot.org/uniprot/A0A6P3EKM6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZMPSTE24 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3U0|||http://purl.uniprot.org/uniprot/W5QG63 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48A family.|||Binds 1 zinc ion per subunit.|||Endoplasmic reticulum membrane|||Proteolytically removes the C-terminal three residues of farnesylated proteins.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101120602 ^@ http://purl.uniprot.org/uniprot/W5P9D6 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:PYGB ^@ http://purl.uniprot.org/uniprot/Q5MIB6 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subunit ^@ Activity of phosphorylase is controlled both by allosteric means (through the non-covalent binding of metabolites) and by covalent modification. Thus AMP allosterically activates, whereas ATP, ADP, and glucose-6-phosphate allosterically inhibit, phosphorylase B (By similarity).|||Belongs to the glycogen phosphorylase family.|||Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.|||Homodimer. Dimers associate into a tetramer to form the enzymatically active phosphorylase A (By similarity).|||Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A. http://togogenome.org/gene/9940:LAMC2 ^@ http://purl.uniprot.org/uniprot/E2QBS9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/9940:PCNA ^@ http://purl.uniprot.org/uniprot/A0A6P3E961 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/9940:LOC101123127 ^@ http://purl.uniprot.org/uniprot/A0A836AE67 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MAT2A ^@ http://purl.uniprot.org/uniprot/W5QH42 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/9940:LOC101123171 ^@ http://purl.uniprot.org/uniprot/W5QHG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9940:LOC101115410 ^@ http://purl.uniprot.org/uniprot/A0A6P3EP25 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRPL20 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJR9|||http://purl.uniprot.org/uniprot/W5P016 ^@ Caution|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101104321 ^@ http://purl.uniprot.org/uniprot/A0A6P3TIJ5 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EDNRA ^@ http://purl.uniprot.org/uniprot/Q95L55|||http://purl.uniprot.org/uniprot/W5PE99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/9940:GPCPD1 ^@ http://purl.uniprot.org/uniprot/A0A835ZWC9 ^@ Caution|||Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SIKE1 ^@ http://purl.uniprot.org/uniprot/W5QFN6 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/9940:API5 ^@ http://purl.uniprot.org/uniprot/A0A6P3EML8 ^@ Caution|||Similarity ^@ Belongs to the API5 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NDUFB5 ^@ http://purl.uniprot.org/uniprot/A0A8N7XJ68 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HSCB ^@ http://purl.uniprot.org/uniprot/W5NXH4 ^@ Similarity ^@ Belongs to the HscB family. http://togogenome.org/gene/9940:GH ^@ http://purl.uniprot.org/uniprot/P67930 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.|||Secreted http://togogenome.org/gene/9940:FSHR ^@ http://purl.uniprot.org/uniprot/P35379 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||G protein-coupled receptor for follitropin, the follicle-stimulating hormone. The activity of isoform FSH-R1 is mediated by G proteins which activate adenylate cyclase (PubMed:10527886, PubMed:9364440). Isoform FSH-R2 and isoform FSH-R3 also bind FSH, but this does not result in activation of adenylate cyclase (PubMed:10527886, PubMed:9364440). Isoform FSH-R3 may be involved in calcium signaling (PubMed:10527886). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (By similarity).|||Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (By similarity). Interacts with ARRB2 (By similarity). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation (By similarity).|||Isoform FSH-R3 is expressed in ovary and testis, but not in kidney (at protein level).|||N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.|||Sulfated. http://togogenome.org/gene/9940:PRRC1 ^@ http://purl.uniprot.org/uniprot/W5Q8M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRRC1 family.|||Golgi apparatus http://togogenome.org/gene/9940:LOC101102567 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6H3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MCTP1 ^@ http://purl.uniprot.org/uniprot/W5Q5V1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:CCDC137 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHP5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATP2B3 ^@ http://purl.uniprot.org/uniprot/W5PCE8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9940:CCDC86 ^@ http://purl.uniprot.org/uniprot/W5Q1V5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:LRRC8D ^@ http://purl.uniprot.org/uniprot/W5PKY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:SERPINA14 ^@ http://purl.uniprot.org/uniprot/P21814 ^@ PTM|||Similarity|||Tissue Specificity ^@ Belongs to the serpin family. UTMP subfamily.|||Glycosylated; carries the so-called mannose 6-phosphate lysosomal recognition marker on its carbohydrate chains.|||Secreted by ovine endometrium under the influence of progesterone. http://togogenome.org/gene/9940:CHEK1 ^@ http://purl.uniprot.org/uniprot/W5PPW3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. http://togogenome.org/gene/9940:MSTO1 ^@ http://purl.uniprot.org/uniprot/W5P3D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the misato family.|||Mitochondrion outer membrane http://togogenome.org/gene/9940:LOC101118831 ^@ http://purl.uniprot.org/uniprot/W5QBM0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/9940:GALNS ^@ http://purl.uniprot.org/uniprot/W5PVT3 ^@ PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sulfatase family.|||Homodimer.|||Lysosome|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9940:ZBTB39 ^@ http://purl.uniprot.org/uniprot/A0A836D406 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CPQ ^@ http://purl.uniprot.org/uniprot/A0A6P3TQK8|||http://purl.uniprot.org/uniprot/A0A6P7EER3 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.|||Endoplasmic reticulum|||Golgi apparatus|||Homodimer. The monomeric form is inactive while the homodimer is active.|||Lysosome|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101122359 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5P1|||http://purl.uniprot.org/uniprot/W5P446 ^@ Caution|||Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ITPR2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E860|||http://purl.uniprot.org/uniprot/W5QF81 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the InsP3 receptor family.|||Endoplasmic reticulum membrane|||Homotetramer.|||Membrane|||Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.|||The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MFSD9 ^@ http://purl.uniprot.org/uniprot/A0A836D4T1|||http://purl.uniprot.org/uniprot/W5PU30 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DNASE2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4H2 ^@ Caution|||Similarity ^@ Belongs to the DNase II family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101122904 ^@ http://purl.uniprot.org/uniprot/A0A6P3TND1|||http://purl.uniprot.org/uniprot/W5PV69 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MSMB ^@ http://purl.uniprot.org/uniprot/A0A6P3EGV0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MGAT2 ^@ http://purl.uniprot.org/uniprot/W5NRR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 16 (GT16) protein family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9940:KCNS2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YN21|||http://purl.uniprot.org/uniprot/W5PZ34 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9940:GCHFR ^@ http://purl.uniprot.org/uniprot/A0A6P3E624|||http://purl.uniprot.org/uniprot/W5QGB6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GFRP family.|||Membrane|||Nucleus membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytosol http://togogenome.org/gene/9940:CRYZ ^@ http://purl.uniprot.org/uniprot/A0A6P3DYF0|||http://purl.uniprot.org/uniprot/W5PSF8 ^@ Caution|||Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101104234 ^@ http://purl.uniprot.org/uniprot/A0A6P3TE17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9940:MANEA ^@ http://purl.uniprot.org/uniprot/W5PRE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9940:RIOK3 ^@ http://purl.uniprot.org/uniprot/W5PDX2 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.|||Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. http://togogenome.org/gene/9940:ITGB6 ^@ http://purl.uniprot.org/uniprot/B0FYY3|||http://purl.uniprot.org/uniprot/Q863C4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the integrin beta chain family.|||Heterodimer of an alpha and a beta subunit (By similarity). Interacts with FLNB. Interacts with HAX1. ITGAV:ITGB6 interacts with FBN1 (By similarity). ITGAV:ITGB6 interacts with TGFB1 (By similarity).|||Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity).|||Membrane|||focal adhesion http://togogenome.org/gene/9940:CCL28 ^@ http://purl.uniprot.org/uniprot/A6N8N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9940:LPL ^@ http://purl.uniprot.org/uniprot/Q29524 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Cell membrane|||Homodimer. Interacts with GPIHBP1 with 1:1 stoichiometry (By similarity). Interacts with APOC2; the interaction activates LPL activity in the presence of lipids (By similarity). Interaction with heparan sulfate proteoglycans is required to protect LPL against loss of activity. Associates with lipoprotein particles in blood plasma. Interacts with LMF1 and SEL1L; interaction with SEL1L is required to prevent aggregation of newly synthesized LPL in the endoplasmic reticulum (ER), and for normal export of LPL from the ER to the extracellular space (By similarity). Interacts with SORL1; SORL1 acts as a sorting receptor, promoting LPL localization to endosomes and later to lysosomes, leading to degradation of newly synthesized LPL (By similarity).|||Key enzyme in triglyceride metabolism (By similarity). Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (By similarity). Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity (By similarity). Mediates margination of triglyceride-rich lipoprotein particles in capillaries (By similarity). Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (By similarity).|||Secreted|||The apolipoprotein APOC2 acts as a coactivator of LPL activity (By similarity). Ca(2+) binding promotes protein stability and formation of the active homodimer. Interaction with GPIHBP1 protects LPL against inactivation by ANGPTL4 (By similarity).|||Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.|||extracellular matrix http://togogenome.org/gene/9940:SCNN1G ^@ http://purl.uniprot.org/uniprot/W5Q558 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:PECR ^@ http://purl.uniprot.org/uniprot/A0A836ADY5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AQP4 ^@ http://purl.uniprot.org/uniprot/A0A6P3TFZ5|||http://purl.uniprot.org/uniprot/Q866S4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:LOC101119008 ^@ http://purl.uniprot.org/uniprot/W5PLT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:ENPP6 ^@ http://purl.uniprot.org/uniprot/A0A6P3EH01|||http://purl.uniprot.org/uniprot/W5PBV4 ^@ Caution|||Similarity ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GADD45B ^@ http://purl.uniprot.org/uniprot/A0A6P3ECN5|||http://purl.uniprot.org/uniprot/W5PW26 ^@ Caution|||Similarity ^@ Belongs to the GADD45 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:STING1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TE04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STING family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||Mitochondrion outer membrane|||autophagosome membrane|||perinuclear region http://togogenome.org/gene/9940:KICS2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E2X9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ADIPOR2 ^@ http://purl.uniprot.org/uniprot/W5PTD2|||http://purl.uniprot.org/uniprot/W8FSV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9940:LPIN1 ^@ http://purl.uniprot.org/uniprot/J9S2T1 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/9940:PGD ^@ http://purl.uniprot.org/uniprot/P00349 ^@ Function|||Sequence Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Cytoplasm|||Homodimer.|||Incorrect CNBR peptide order. Many sequencing errors. http://togogenome.org/gene/9940:NOP56 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBR5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:GNL3 ^@ http://purl.uniprot.org/uniprot/A0A836CU51 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SNX11 ^@ http://purl.uniprot.org/uniprot/W5PBK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/9940:FGFBP1 ^@ http://purl.uniprot.org/uniprot/W5PDM2 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/9940:MC4R ^@ http://purl.uniprot.org/uniprot/B2MV59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). http://togogenome.org/gene/9940:SRP14 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7K7|||http://purl.uniprot.org/uniprot/B0LRP7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP14 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm|||Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MYF5 ^@ http://purl.uniprot.org/uniprot/W5Q0M6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/9940:ZUP1 ^@ http://purl.uniprot.org/uniprot/W5PH36 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C78 family. ZUFSP subfamily.|||Interacts with RPA1 and RPA2. http://togogenome.org/gene/9940:WASHC5 ^@ http://purl.uniprot.org/uniprot/A0A6P3YN70 ^@ Caution|||Similarity ^@ Belongs to the strumpellin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CNOT7 ^@ http://purl.uniprot.org/uniprot/A0A6P3ERK4|||http://purl.uniprot.org/uniprot/W5PI55 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPA2 ^@ http://purl.uniprot.org/uniprot/W5NZ54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 2 family.|||Nucleus http://togogenome.org/gene/9940:ZDHHC23 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4W1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9940:LOC101112179 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZT2|||http://purl.uniprot.org/uniprot/W5PAX0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HSD17B10 ^@ http://purl.uniprot.org/uniprot/W5PF12 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9940:PLA2G2D ^@ http://purl.uniprot.org/uniprot/W5PI86 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9940:DEFB116 ^@ http://purl.uniprot.org/uniprot/A0A2V0A0S6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9940:DBP ^@ http://purl.uniprot.org/uniprot/A0A6P3CX42|||http://purl.uniprot.org/uniprot/B6CM52 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TPPP3 ^@ http://purl.uniprot.org/uniprot/A0A836A0R3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TPPP family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytoskeleton http://togogenome.org/gene/9940:LOC101115213 ^@ http://purl.uniprot.org/uniprot/A0A6P3EET2|||http://purl.uniprot.org/uniprot/W5QEQ8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.|||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SNRPN ^@ http://purl.uniprot.org/uniprot/W5PH28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP SmB/SmN family.|||Nucleus http://togogenome.org/gene/9940:LOC101122400 ^@ http://purl.uniprot.org/uniprot/A0A836CQV6|||http://purl.uniprot.org/uniprot/W5P1N9 ^@ Caution|||Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MX2 ^@ http://purl.uniprot.org/uniprot/Q5I2P5 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.|||By type I and type III interferons.|||Cytoplasm|||Interferon-induced dynamin-like GTPase with antiviral activity.|||Nucleus http://togogenome.org/gene/9940:UPK1A ^@ http://purl.uniprot.org/uniprot/W5P4F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9940:AK6 ^@ http://purl.uniprot.org/uniprot/W5P6L6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.|||Cajal body|||Monomer and homodimer. Interacts with COIL (via C-terminus).|||nucleoplasm http://togogenome.org/gene/9940:NDUFB3 ^@ http://purl.uniprot.org/uniprot/A0A6P7DQB1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB3 subunit family.|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CHRDL2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGN3|||http://purl.uniprot.org/uniprot/W5PL83 ^@ Caution|||Subcellular Location Annotation ^@ Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NOSTRIN ^@ http://purl.uniprot.org/uniprot/A0A6P3T904 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101102223 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3Z9|||http://purl.uniprot.org/uniprot/W5QGM7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRAPPC6B ^@ http://purl.uniprot.org/uniprot/A0A6P3EBX2|||http://purl.uniprot.org/uniprot/W5PFI1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cis-Golgi network http://togogenome.org/gene/9940:CD164 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGU1|||http://purl.uniprot.org/uniprot/W5PLD6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SUSD1 ^@ http://purl.uniprot.org/uniprot/W5P9C3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:POLR2M ^@ http://purl.uniprot.org/uniprot/W5QI74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRINL1 family.|||Nucleus http://togogenome.org/gene/9940:PA2G4 ^@ http://purl.uniprot.org/uniprot/W5PKW0 ^@ Similarity ^@ Belongs to the peptidase M24 family. http://togogenome.org/gene/9940:GMPR ^@ http://purl.uniprot.org/uniprot/A0A6P3EP35|||http://purl.uniprot.org/uniprot/W5PRM0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101106910 ^@ http://purl.uniprot.org/uniprot/W5NZS5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9940:ELOC ^@ http://purl.uniprot.org/uniprot/A0A836D201 ^@ Caution|||Similarity ^@ Belongs to the SKP1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:E2F8 ^@ http://purl.uniprot.org/uniprot/W5PG88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9940:RGR ^@ http://purl.uniprot.org/uniprot/W5NPY9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:LOC101121373 ^@ http://purl.uniprot.org/uniprot/W5P9H2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:SPX ^@ http://purl.uniprot.org/uniprot/U5YRS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spexin family.|||Secreted http://togogenome.org/gene/9940:LOC101119852 ^@ http://purl.uniprot.org/uniprot/A0A835ZWP3 ^@ Caution|||Subcellular Location Annotation ^@ Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SEC62 ^@ http://purl.uniprot.org/uniprot/A0A6P3E0D5|||http://purl.uniprot.org/uniprot/W5NQN5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC62 family.|||Endoplasmic reticulum membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101123268 ^@ http://purl.uniprot.org/uniprot/W5PEC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9940:CCNG2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EF97 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9940:LOC101111389 ^@ http://purl.uniprot.org/uniprot/W5P974 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:GNRHR ^@ http://purl.uniprot.org/uniprot/P32237 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9940:VAMP8 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9W7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZNF185 ^@ http://purl.uniprot.org/uniprot/A0A835ZJH2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRKAA1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDP8|||http://purl.uniprot.org/uniprot/W5PHS9 ^@ Caution|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PTK6 ^@ http://purl.uniprot.org/uniprot/W5PMR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9940:CNTFR ^@ http://purl.uniprot.org/uniprot/A0A6P7DN59 ^@ Similarity ^@ Belongs to the type I cytokine receptor family. Type 3 subfamily. http://togogenome.org/gene/9940:VASH1 ^@ http://purl.uniprot.org/uniprot/A0A836A3U9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRPL49 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQM8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL49 family.|||Mitochondrion|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SPINK4 ^@ http://purl.uniprot.org/uniprot/A0A6P3E124|||http://purl.uniprot.org/uniprot/W5PIF8 ^@ Caution|||Subcellular Location Annotation ^@ Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HDAC8 ^@ http://purl.uniprot.org/uniprot/W5Q8N1 ^@ Similarity ^@ Belongs to the histone deacetylase family. HD type 1 subfamily. http://togogenome.org/gene/9940:ATXN3 ^@ http://purl.uniprot.org/uniprot/B3VSB5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:PIK3CG ^@ http://purl.uniprot.org/uniprot/A0A836AHH4 ^@ Caution|||Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPL24 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7S8 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRNP ^@ http://purl.uniprot.org/uniprot/A0A836A7F4|||http://purl.uniprot.org/uniprot/P23907|||http://purl.uniprot.org/uniprot/Q27H92 ^@ Caution|||Disease Annotation|||Domain|||Function|||Miscellaneous|||Polymorphism|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A number of amino acid polymorphism sites that influence scrapie susceptibility and transmission have been described. These are alanine to threonine or valine at codon 136, arginine to histidine at codon 154, and arginine to glutamine, histidine or lysine at codon 171. A number of allelic variants have been described based on the amino acids found at these three positions: VRQ, ARQ, AHQ, TRQ, ARK, ARR and ARH.|||Belongs to the prion family.|||Cell membrane|||Contains an N-terminal region composed of octamer repeats. At low copper concentrations, the sidechains of His residues from three or four repeats contribute to the binding of a single copper ion. Alternatively, a copper ion can be bound by interaction with the sidechain and backbone amide nitrogen of a single His residue. The observed copper binding stoichiometry suggests that two repeat regions cooperate to stabilize the binding of a single copper ion. At higher copper concentrations, each octamer can bind one copper ion by interactions with the His sidechain and Gly backbone atoms. A mixture of binding types may occur, especially in the case of octamer repeat expansion. Copper binding may stabilize the conformation of this region and may promote oligomerization.|||Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.|||Golgi apparatus|||Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).|||Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.|||Membrane|||Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization. Interacts with GRB2, APP, ERI3/PRNPIP and SYN1. Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement. Interacts with KIAA1191.|||Scrapie is a transmissible neurodegenerative disorder of sheep and goats. Most sheep that contract the disease naturally die between 24 and 50 months of age. The incubation period in sheep depends on the strain(s) of the infecting pathogen, sheep age at exposure, and the sheep genotype. Scrapie can be spread between flockmates, or it can be transmitted from an infected ewe to its lamb.|||The alternative prion protein/AltPrP (AC F7VJQ3) and PRNP have no apparent direct functional relation since a mutation that removes the start codon of the AltPrP has no apparent effect on the biology of PRNP (By similarity). In mouse and hamster, the alternative initiation AUG codon is absent and is replaced by a GUG codon.|||The normal, monomeric form has a mainly alpha-helical structure. The disease-associated, protease-resistant form forms amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Disease mutations may favor intermolecular contacts via short beta strands, and may thereby trigger oligomerization.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||This protein is produced by a bicistronic gene which also produces the major prion protein/PRNP from an overlapping reading frame. http://togogenome.org/gene/9940:LOC101104705 ^@ http://purl.uniprot.org/uniprot/W5P530 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9940:LOC101120581 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFQ6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DDX3X ^@ http://purl.uniprot.org/uniprot/W5NWP4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9940:DNAJC7 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHH7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LIN7A ^@ http://purl.uniprot.org/uniprot/W5Q0N9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/9940:CFAP36 ^@ http://purl.uniprot.org/uniprot/A0A6P3E2E2|||http://purl.uniprot.org/uniprot/W5NWA1 ^@ Caution|||Similarity ^@ Belongs to the CFAP36 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ST8SIA4 ^@ http://purl.uniprot.org/uniprot/A0A6P3E696 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GABRG1 ^@ http://purl.uniprot.org/uniprot/W5Q189 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9940:TCP11L2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E381|||http://purl.uniprot.org/uniprot/W5Q7F3 ^@ Caution|||Similarity ^@ Belongs to the TCP11 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ZNF277 ^@ http://purl.uniprot.org/uniprot/W5NX23 ^@ Similarity ^@ Belongs to the ZNF277 family. http://togogenome.org/gene/9940:PTGES3L ^@ http://purl.uniprot.org/uniprot/A0A6P3TX45 ^@ Caution|||Similarity ^@ Belongs to the p23/wos2 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MMGT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TL79|||http://purl.uniprot.org/uniprot/W5PPL4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane magnesium transporter (TC 1.A.67) family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:METTL23 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8B7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C1H1orf189 ^@ http://purl.uniprot.org/uniprot/A0A6P3E778 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GDF9 ^@ http://purl.uniprot.org/uniprot/A0A0M4MFY8|||http://purl.uniprot.org/uniprot/B7U471|||http://purl.uniprot.org/uniprot/O77681 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked (By similarity).|||Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.|||Ovarian physiology and fertility are controlled by endocrine and paracrine signals. These act in a species-dependent manner and determine the ovulation quota in different mammalian species. While humans, and mammals such as the cow or red deer, normally ovulate only one egg per cycle, other mammals such as mouse and pig can ovulate in excess of ten per cycle. The mechanisms that regulate the species-specific differences in the number of follicles that go onto ovulate during each reproductive cycle are poorly understood. According to PubMed:21970812, mRNA expression levels of GDF9 and BMP15 are tightly coregulated within each species and influence species-specific ovulation-rates.|||Phosphorylated; phosphorylation is critical for GDF9 function.|||Required for ovarian folliculogenesis.|||Secreted http://togogenome.org/gene/9940:EDN1 ^@ http://purl.uniprot.org/uniprot/Q9BG76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).|||Secreted http://togogenome.org/gene/9940:DYNC1LI2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJH4|||http://purl.uniprot.org/uniprot/W5NVS4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.|||Belongs to the dynein light intermediate chain family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytoskeleton http://togogenome.org/gene/9940:SMIM19 ^@ http://purl.uniprot.org/uniprot/A0A6P7DIC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM19 family.|||Membrane http://togogenome.org/gene/9940:ANXA3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YIG9|||http://purl.uniprot.org/uniprot/W5QBI9 ^@ Caution|||Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:S100A2 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZ25 ^@ Caution|||Similarity ^@ Belongs to the S-100 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CHRAC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHC0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRKRA ^@ http://purl.uniprot.org/uniprot/A0A6P3E673|||http://purl.uniprot.org/uniprot/W5Q7A3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRKRA family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||perinuclear region http://togogenome.org/gene/9940:TMEM39A ^@ http://purl.uniprot.org/uniprot/A0A6P3DZL5|||http://purl.uniprot.org/uniprot/W5QEN7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CEP76 ^@ http://purl.uniprot.org/uniprot/A0A6P3YSP6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP76 family.|||Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||centriole http://togogenome.org/gene/9940:CDH8 ^@ http://purl.uniprot.org/uniprot/W5NUI5 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:C3H2orf68 ^@ http://purl.uniprot.org/uniprot/A0A6P3E771 ^@ Caution|||Similarity ^@ Belongs to the UPF0561 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LASP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDE6|||http://purl.uniprot.org/uniprot/W5PK26 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9940:GRIA2 ^@ http://purl.uniprot.org/uniprot/W5P8A7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9940:DHFR ^@ http://purl.uniprot.org/uniprot/W5PZI9 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/9940:LOC105616394 ^@ http://purl.uniprot.org/uniprot/W5NPN0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9940:LOC101109530 ^@ http://purl.uniprot.org/uniprot/W5Q9P5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:RMND5B ^@ http://purl.uniprot.org/uniprot/A0A836D352 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NT5E ^@ http://purl.uniprot.org/uniprot/A0A6P3E6T1|||http://purl.uniprot.org/uniprot/W5PUV3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-nucleotidase family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRKACA ^@ http://purl.uniprot.org/uniprot/A0A836D2R9|||http://purl.uniprot.org/uniprot/Q9MZD9 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2. Both isoforms 1 and 2 forms activate cAMP-sensitive PKAI and PKAII holoenzymes by interacting with regulatory subunit (R) of PKA, PRKAR1A/PKR1 and PRKAR2A/PKR2, respectively. Interacts with NFKB1, NFKB2 and NFKBIA in platelets; these interactions are disrupted by thrombin and collagen. Binds to ABL1 in spermatozoa and with CDC25B in oocytes (By similarity) Interacts with APOBEC3G and AICDA (By similarity). Interacts with RAB13; downstream effector of RAB13 involved in tight junction assembly (By similarity). Found in a complex at least composed of MROH2B, PRKACA isoform 2 and TCP11 (By similarity). Interacts with MROH2B (By similarity). Interacts with HSF1 (By similarity). Isoform 2 interacts with TCP11 (By similarity). Interacts with TBC1D31; in the regulation of OFD1 (By similarity).|||Allosterically activated by various compounds, including ATP. Activated by cAMP; the nucleotide acts as a dynamic and allosteric activator by coupling the two lobes of apo PKA, enhancing the enzyme dynamics synchronously and priming it for catalysis.|||Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.|||Autophosphorylated. Phosphorylation is enhanced by vitamin K(2). Phosphorylated on threonine and serine residues. Phosphorylation on Thr-198 is required for full activity (By similarity).|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.|||Cell membrane|||Cytoplasm|||Isoform 2 is sperm specific.|||Membrane|||Mitochondrion|||Nucleus|||Phosphorylated at Tyr-331 by activated receptor tyrosine kinases EGFR and PDGFR; this increases catalytic efficiency.|||Phosphorylates a large number of substrates in the cytoplasm and the nucleus (By similarity). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (By similarity). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (By similarity). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis most probably through the regulation of OFD1 in ciliogenesis (By similarity). Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA. Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (By similarity).|||Predominant somatic isoform.|||Sperm specific.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||acrosome|||flagellum http://togogenome.org/gene/9940:LOC101115172 ^@ http://purl.uniprot.org/uniprot/W5PWD7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9940:CLVS1 ^@ http://purl.uniprot.org/uniprot/W5Q4N0 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Vesicle|||clathrin-coated vesicle|||trans-Golgi network membrane http://togogenome.org/gene/9940:ENTPD4 ^@ http://purl.uniprot.org/uniprot/W5PK69 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9940:TAF13 ^@ http://purl.uniprot.org/uniprot/A0A6P3E476|||http://purl.uniprot.org/uniprot/W5QCJ9 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101116157 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7U8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101117960 ^@ http://purl.uniprot.org/uniprot/W5NXY7 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9940:AFM ^@ http://purl.uniprot.org/uniprot/W5PXI3 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9940:NAA10 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHQ2 ^@ Caution|||Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CYP1A1 ^@ http://purl.uniprot.org/uniprot/P56591 ^@ Caution|||Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15alpha and C16alpha positions. Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation. Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system. Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer. May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent).|||Belongs to the cytochrome P450 family.|||By oxygen; in lung.|||Cytoplasm|||Endoplasmic reticulum membrane|||Increased expression of this enzyme in lung due to oxygen exposure has been related to hyperoxic injury in microvascular endothelium.|||Interacts with cytosolic chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria. Interacts (via mitochondrial targeting signal) with TOMM40 (via N-terminus); this interaction is required for translocation across the mitochondrial outer membrane.|||It is uncertain whether Met-1 or Met-4 is the initiator.|||Microsome membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9940:RIT1 ^@ http://purl.uniprot.org/uniprot/A0A836D9Y5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C15H11orf58 ^@ http://purl.uniprot.org/uniprot/A0A6P3EKA0|||http://purl.uniprot.org/uniprot/W5P6R9 ^@ Caution|||Similarity ^@ Belongs to the SMAP family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RIOK1 ^@ http://purl.uniprot.org/uniprot/W5Q8K2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/9940:MIF ^@ http://purl.uniprot.org/uniprot/A0A835ZR82|||http://purl.uniprot.org/uniprot/Q1ZZU7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MIF family.|||Cytoplasm|||Homotrimer (By similarity). Interacts with CXCR2 extracellular domain (By similarity). Interacts with the CD74 extracellular domain, USO1, COPS5 and BNIPL (By similarity).|||Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CD320 ^@ http://purl.uniprot.org/uniprot/W5P0H1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:LOC106991327 ^@ http://purl.uniprot.org/uniprot/A0A835ZJ51|||http://purl.uniprot.org/uniprot/K4P217 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL22 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AVPR2 ^@ http://purl.uniprot.org/uniprot/E3VJQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.|||Membrane http://togogenome.org/gene/9940:IGFBP4 ^@ http://purl.uniprot.org/uniprot/B5AZT5 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds IGF2 more than IGF1.|||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9940:HMGN4 ^@ http://purl.uniprot.org/uniprot/A0A6P7D826 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9940:INSYN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TIA8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KCTD13 ^@ http://purl.uniprot.org/uniprot/A0A6P3ERM0|||http://purl.uniprot.org/uniprot/W5P4N7 ^@ Caution|||Similarity ^@ Belongs to the BACURD family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FABP4 ^@ http://purl.uniprot.org/uniprot/A9YUY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm http://togogenome.org/gene/9940:CDH19 ^@ http://purl.uniprot.org/uniprot/W5P4R8 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:LOC100134870 ^@ http://purl.uniprot.org/uniprot/A0A0F6YFJ0|||http://purl.uniprot.org/uniprot/P68056 ^@ Function|||Miscellaneous|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the globin family.|||Heterotetramer of two alpha chains and two beta chains.|||Involved in oxygen transport from the lung to the various peripheral tissues.|||Red blood cells.|||This type of beta-C chain is found when anemia has been experimentally produced. http://togogenome.org/gene/9940:GOLPH3L ^@ http://purl.uniprot.org/uniprot/A0A836APL5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||trans-Golgi network membrane http://togogenome.org/gene/9940:GJB6 ^@ http://purl.uniprot.org/uniprot/A0A6P3TQW7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9940:EXTL2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E466 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9940:ABHD14B ^@ http://purl.uniprot.org/uniprot/A0A6P3EC93 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CZIB ^@ http://purl.uniprot.org/uniprot/W5P893 ^@ Similarity ^@ Belongs to the UPF0587 family. http://togogenome.org/gene/9940:PUS3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFD5|||http://purl.uniprot.org/uniprot/A0A6P3T4D7 ^@ Caution|||Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CLRN2 ^@ http://purl.uniprot.org/uniprot/A0A836D4T8|||http://purl.uniprot.org/uniprot/W5PL63 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:JOSD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YIU8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PROS1 ^@ http://purl.uniprot.org/uniprot/W5Q749 ^@ Caution|||Function ^@ Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:LOC101122597 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDN3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NQO1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFH4|||http://purl.uniprot.org/uniprot/W5P093 ^@ Caution|||Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KCNG3 ^@ http://purl.uniprot.org/uniprot/W5PC39 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9940:CNFN ^@ http://purl.uniprot.org/uniprot/W5PCW7 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9940:PGAP1 ^@ http://purl.uniprot.org/uniprot/W5Q0I0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI inositol-deacylase family.|||Endoplasmic reticulum membrane|||Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.|||Membrane http://togogenome.org/gene/9940:RAP1GDS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6Q7|||http://purl.uniprot.org/uniprot/W5Q4B7 ^@ Caution|||Subcellular Location Annotation ^@ Endoplasmic reticulum|||Mitochondrion|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytosol http://togogenome.org/gene/9940:KLHL9 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9E2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:YME1L1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E908 ^@ Caution|||Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DR1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6P8|||http://purl.uniprot.org/uniprot/W5Q5L9 ^@ Caution|||Similarity ^@ Belongs to the NC2 beta/DR1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRIM37 ^@ http://purl.uniprot.org/uniprot/A0A6P3TWF5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UPK1B ^@ http://purl.uniprot.org/uniprot/W5QEI2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tetraspanin (TM4SF) family.|||Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).|||Membrane http://togogenome.org/gene/9940:GK2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAI2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FGGY kinase family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SELE ^@ http://purl.uniprot.org/uniprot/Q95LG2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selectin/LECAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9940:HBM ^@ http://purl.uniprot.org/uniprot/W5PMN1 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9940:RPL32 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECF2|||http://purl.uniprot.org/uniprot/W5Q000 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AGBL5 ^@ http://purl.uniprot.org/uniprot/W5QCN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Midbody|||Nucleus|||cytosol|||spindle http://togogenome.org/gene/9940:LHX4 ^@ http://purl.uniprot.org/uniprot/W5Q9X8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:XCL1 ^@ http://purl.uniprot.org/uniprot/A0A6P9FNA1|||http://purl.uniprot.org/uniprot/Q867A6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Belongs to the intercrine gamma family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AQP11 ^@ http://purl.uniprot.org/uniprot/W5PB79 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|||Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:GJD2 ^@ http://purl.uniprot.org/uniprot/W5QFG4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9940:ORMDL3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDG1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORM family.|||Endoplasmic reticulum membrane|||Interacts with SPTLC1.|||Membrane|||Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ACSM2B ^@ http://purl.uniprot.org/uniprot/W5PTC2 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9940:ATP2C1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TG41|||http://purl.uniprot.org/uniprot/W5PI39 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Golgi stack membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. Homodimer.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||trans-Golgi network membrane http://togogenome.org/gene/9940:APOO ^@ http://purl.uniprot.org/uniprot/A0A6P3EEV2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HADH ^@ http://purl.uniprot.org/uniprot/W5PEH2 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/9940:LOC105608906 ^@ http://purl.uniprot.org/uniprot/W5QEA3 ^@ Similarity ^@ Belongs to the HSBP1 family. http://togogenome.org/gene/9940:RNF34 ^@ http://purl.uniprot.org/uniprot/A0A6P3T6A0|||http://purl.uniprot.org/uniprot/W5PYL3 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9940:KBTBD8 ^@ http://purl.uniprot.org/uniprot/A0A6P3EPD8|||http://purl.uniprot.org/uniprot/W5PLA2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KBTBD8 family.|||Golgi apparatus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||spindle http://togogenome.org/gene/9940:MRPL18 ^@ http://purl.uniprot.org/uniprot/W5P386 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL18 family. http://togogenome.org/gene/9940:XPNPEP3 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECJ5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CMKLR1 ^@ http://purl.uniprot.org/uniprot/A0A835ZZJ9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TBCCD1 ^@ http://purl.uniprot.org/uniprot/W5QH62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCC family.|||centrosome|||spindle pole http://togogenome.org/gene/9940:METTL4 ^@ http://purl.uniprot.org/uniprot/H9CJU7 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/9940:LOC101114968 ^@ http://purl.uniprot.org/uniprot/W5P577 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family. CENP-S/MHF1 subfamily.|||Nucleus|||kinetochore http://togogenome.org/gene/9940:GYG1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YFI9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101102824 ^@ http://purl.uniprot.org/uniprot/W5PUV7 ^@ Similarity ^@ Belongs to the TACO1 family. http://togogenome.org/gene/9940:GTF2H3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHT2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB4 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.|||Nucleus|||Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPL8 ^@ http://purl.uniprot.org/uniprot/A0A6P3EG68|||http://purl.uniprot.org/uniprot/W5PSW9 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL2 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PIP4K2A ^@ http://purl.uniprot.org/uniprot/A0A6P3EEK8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IL13 ^@ http://purl.uniprot.org/uniprot/Q0PW91 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-4/IL-13 family.|||Interacts with IL13RA2.|||Secreted http://togogenome.org/gene/9940:KRT74 ^@ http://purl.uniprot.org/uniprot/W5Q659 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9940:KEF53_p13 ^@ http://purl.uniprot.org/uniprot/A0A0E3JG63|||http://purl.uniprot.org/uniprot/O78747 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 1 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9940:SLC9A9 ^@ http://purl.uniprot.org/uniprot/W5P6Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9940:NOL12 ^@ http://purl.uniprot.org/uniprot/A0A6P3ECI0|||http://purl.uniprot.org/uniprot/W5PX01 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP17 family.|||Interacts with KIAA1191.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:RAB39A ^@ http://purl.uniprot.org/uniprot/A0A6P3ECQ8|||http://purl.uniprot.org/uniprot/W5PMH4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IRF1 ^@ http://purl.uniprot.org/uniprot/Q9BG75 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9940:KCNA10 ^@ http://purl.uniprot.org/uniprot/W5PPM2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9940:KLF9 ^@ http://purl.uniprot.org/uniprot/A0A6P3E995 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101104364 ^@ http://purl.uniprot.org/uniprot/W5PJ06 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:LOC101114777 ^@ http://purl.uniprot.org/uniprot/W5Q5T8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:RPS17 ^@ http://purl.uniprot.org/uniprot/A0A6P3CXL7|||http://purl.uniprot.org/uniprot/K4P486 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101112257 ^@ http://purl.uniprot.org/uniprot/W5PSL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PLAC1 family.|||Secreted http://togogenome.org/gene/9940:TLR7 ^@ http://purl.uniprot.org/uniprot/B5DC92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Endoplasmic reticulum membrane|||Lysosome|||Membrane|||phagosome http://togogenome.org/gene/9940:FGGY ^@ http://purl.uniprot.org/uniprot/W5PF90 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/9940:PROKR2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EET3|||http://purl.uniprot.org/uniprot/W5Q7K4 ^@ Caution|||Similarity ^@ Belongs to the G-protein coupled receptor 1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TRAF1 ^@ http://purl.uniprot.org/uniprot/W5P6H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9940:TENT5B ^@ http://purl.uniprot.org/uniprot/W5P139 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9940:MASTL ^@ http://purl.uniprot.org/uniprot/A0A6P3TJ63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Nucleus|||centrosome http://togogenome.org/gene/9940:HYAL2 ^@ http://purl.uniprot.org/uniprot/A0A835ZNQ6|||http://purl.uniprot.org/uniprot/Q8SQG7 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a receptor for the Jaagsiekte sheep retrovirus (JSRV), which induces ovine pulmonary adenocarcinoma. A possible mechanism is that binding to JSRV envelope proteins may liberate the oncogenic factor MST1R that is normally negatively regulated by HYAL2, leading to oncogenic transformation.|||Belongs to the glycosyl hydrolase 56 family.|||Cell membrane|||Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity).|||Interacts with MST1R (By similarity). Interacts with Jaagsiekte sheep retrovirus (JSRV) envelope proteins.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CD3E ^@ http://purl.uniprot.org/uniprot/P29328|||http://purl.uniprot.org/uniprot/Q3S1N5 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Membrane|||Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.|||Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.|||The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. Interacts with CD6. Interacts with NCK1. Interacts with NUMB; this interaction is important for TCR-CD3 internalization and subsequent degradation. http://togogenome.org/gene/9940:CYGB ^@ http://purl.uniprot.org/uniprot/A0A6P3CXP0|||http://purl.uniprot.org/uniprot/C8BKE0 ^@ Caution|||Similarity ^@ Belongs to the globin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SSTR3 ^@ http://purl.uniprot.org/uniprot/W5QG61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:SMAP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E662 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EIF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDI7 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/9940:IGF2BP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YL83|||http://purl.uniprot.org/uniprot/M4R4L7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||P-body|||Stress granule|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||filopodium|||lamellipodium http://togogenome.org/gene/9940:GPSM3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YP89 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OSGEPL1 ^@ http://purl.uniprot.org/uniprot/A0A836AME1|||http://purl.uniprot.org/uniprot/W5Q489 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion|||Monomer.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC25A10 ^@ http://purl.uniprot.org/uniprot/B2MVX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9940:MAEL ^@ http://purl.uniprot.org/uniprot/A0A6P3E7I9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the maelstrom family.|||Nucleus|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARL14EPL ^@ http://purl.uniprot.org/uniprot/A0A6P3TI40 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EIF1AD ^@ http://purl.uniprot.org/uniprot/A0A6P3EPQ5|||http://purl.uniprot.org/uniprot/W5NSN1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the EIF1AD family.|||Interacts with GAPDH and STAT1.|||Plays a role into cellular response to oxidative stress. Decreases cell proliferation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C3H2orf42 ^@ http://purl.uniprot.org/uniprot/A0A6P3E279 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MPP7 ^@ http://purl.uniprot.org/uniprot/W5Q1H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||adherens junction|||tight junction http://togogenome.org/gene/9940:APOF ^@ http://purl.uniprot.org/uniprot/A0A836A872 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CSN1S1 ^@ http://purl.uniprot.org/uniprot/G3LUQ4|||http://purl.uniprot.org/uniprot/P04653 ^@ Function|||Polymorphism|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ At least four alleles are known. The sequence shown is that of allele A. The frequency of variant Thr-209 is 0.263, 0.122 and 0.191 in Italian breeds Comisana, Sarda and Sopravissana, respectively.|||Belongs to the alpha-casein family.|||Important role in the capacity of milk to transport calcium phosphate.|||Mammary gland specific. Secreted in milk.|||Secreted http://togogenome.org/gene/9940:SCD ^@ http://purl.uniprot.org/uniprot/O62849 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Endoplasmic reticulum membrane|||Expected to bind 2 Fe(2+) ions per subunit.|||Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/9940:DVL2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EIF7|||http://purl.uniprot.org/uniprot/W5PMC0 ^@ Caution|||Similarity ^@ Belongs to the DSH family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CNTF ^@ http://purl.uniprot.org/uniprot/A0A6P3ED95|||http://purl.uniprot.org/uniprot/W5PNJ0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNTF family.|||CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRPL48 ^@ http://purl.uniprot.org/uniprot/A0A6P3ED45 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PIR ^@ http://purl.uniprot.org/uniprot/A0A6P3EH18 ^@ Caution|||Similarity ^@ Belongs to the pirin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC105608827 ^@ http://purl.uniprot.org/uniprot/A0A836A6D3 ^@ Caution|||Function|||Similarity ^@ Belongs to the universal ribosomal protein uL11 family.|||Binds directly to 26S ribosomal RNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LIN9 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE22 ^@ Caution|||Similarity ^@ Belongs to the lin-9 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101114385 ^@ http://purl.uniprot.org/uniprot/W5P9F1 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:F2RL2 ^@ http://purl.uniprot.org/uniprot/W5Q630 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9940:MAP4K1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TZD5 ^@ Caution|||Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CYB561 ^@ http://purl.uniprot.org/uniprot/A0A835ZVR5|||http://purl.uniprot.org/uniprot/Q95204 ^@ Caution|||Cofactor|||Function|||Subcellular Location Annotation ^@ Binds 2 heme b groups non-covalently.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce monodehydro-L-ascorbate radical in the lumen of secretory vesicles. It is therefore involved the regeneration and homeostasis within secretory vesicles of ascorbate which in turn provides reducing equivalents needed to support the activity of intravesicular enzymes.|||chromaffin granule membrane http://togogenome.org/gene/9940:BCL2L11 ^@ http://purl.uniprot.org/uniprot/A0A6P3TPJ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Bcl-2 family.|||Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1.|||Induces apoptosis and anoikis. http://togogenome.org/gene/9940:LOC101116849 ^@ http://purl.uniprot.org/uniprot/A0A6P3E945 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SMC3 ^@ http://purl.uniprot.org/uniprot/W5PJ45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC3 subfamily.|||Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.|||Nucleus|||centromere http://togogenome.org/gene/9940:TSPAN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3DYP9|||http://purl.uniprot.org/uniprot/A0A6P3T8R3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CNTN1 ^@ http://purl.uniprot.org/uniprot/W5QF51 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. Contactin family. http://togogenome.org/gene/9940:KLHL13 ^@ http://purl.uniprot.org/uniprot/A0A6P3YQE1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ALDOA ^@ http://purl.uniprot.org/uniprot/A0A6P7DGM3 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9940:SACM1L ^@ http://purl.uniprot.org/uniprot/A0A836CUA3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MMP2 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQM5|||http://purl.uniprot.org/uniprot/C8BKE4 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M10A family.|||Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||extracellular matrix http://togogenome.org/gene/9940:CCR7 ^@ http://purl.uniprot.org/uniprot/W5PZG4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9940:KRT2.11 ^@ http://purl.uniprot.org/uniprot/E3VW87 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9940:CIDEA ^@ http://purl.uniprot.org/uniprot/A0A835ZV84 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MDM4 ^@ http://purl.uniprot.org/uniprot/A0A6P7ELG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.|||Nucleus http://togogenome.org/gene/9940:ZNF75D ^@ http://purl.uniprot.org/uniprot/A0A835ZHV9 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NR1H4 ^@ http://purl.uniprot.org/uniprot/W5PWS7|||http://purl.uniprot.org/uniprot/W5PWT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9940:PON1 ^@ http://purl.uniprot.org/uniprot/W5NY46 ^@ Cofactor|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit. http://togogenome.org/gene/9940:NAPA ^@ http://purl.uniprot.org/uniprot/A0A6P3YML3|||http://purl.uniprot.org/uniprot/W5PNM6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101104165 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9940:LOC101122140 ^@ http://purl.uniprot.org/uniprot/A0A6P3YS28|||http://purl.uniprot.org/uniprot/W5PVN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.|||Nucleus http://togogenome.org/gene/9940:TSPAN31 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAQ2|||http://purl.uniprot.org/uniprot/W5P5M1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCDC60 ^@ http://purl.uniprot.org/uniprot/A0A836A1Y7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ARID2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E355 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CES2 ^@ http://purl.uniprot.org/uniprot/W5NX87 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/9940:ARFRP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TJ40 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPM1G ^@ http://purl.uniprot.org/uniprot/A0A6P3E2H7|||http://purl.uniprot.org/uniprot/W5QDE0 ^@ Caution|||Similarity ^@ Belongs to the PP2C family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:JPT1 ^@ http://purl.uniprot.org/uniprot/W5PNC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9940:LOC101109939 ^@ http://purl.uniprot.org/uniprot/W5P8W4 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9940:SNX16 ^@ http://purl.uniprot.org/uniprot/A0A6P3E997 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101108669 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDR8|||http://purl.uniprot.org/uniprot/W5Q462 ^@ Caution|||Similarity ^@ Belongs to the fructosamine kinase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC12A6 ^@ http://purl.uniprot.org/uniprot/A0A6P3TQM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9940:CDH7 ^@ http://purl.uniprot.org/uniprot/W5P4X1 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:COQ3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBS4|||http://purl.uniprot.org/uniprot/W5PQM3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Mitochondrion inner membrane|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NCEH1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E538|||http://purl.uniprot.org/uniprot/W5QHT6 ^@ Caution|||Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:IKZF3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E846 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRPL13 ^@ http://purl.uniprot.org/uniprot/A0A836CZE8|||http://purl.uniprot.org/uniprot/W5Q7J1 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL13 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RACGAP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E2T2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RBM26 ^@ http://purl.uniprot.org/uniprot/A0A6P3THG9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TLR8 ^@ http://purl.uniprot.org/uniprot/A0A6P3TAK9|||http://purl.uniprot.org/uniprot/B5DC93 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PIGM ^@ http://purl.uniprot.org/uniprot/A0A6P3DZU2|||http://purl.uniprot.org/uniprot/W5PBS7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGM family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PAGE4 ^@ http://purl.uniprot.org/uniprot/W5PEQ5 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9940:AK8 ^@ http://purl.uniprot.org/uniprot/A0A836AHU6|||http://purl.uniprot.org/uniprot/W5P6Y6 ^@ Caution|||Similarity ^@ Belongs to the adenylate kinase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AVPI1 ^@ http://purl.uniprot.org/uniprot/W5PNG1 ^@ Function ^@ May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling. http://togogenome.org/gene/9940:MEP1B ^@ http://purl.uniprot.org/uniprot/W5P7X2 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9940:TRAPPC13 ^@ http://purl.uniprot.org/uniprot/A0A6P3TFY9 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the TRAPPC13 family.|||Part of the multisubunit TRAPP (transport protein particle) complex.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:INTS9 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8D6|||http://purl.uniprot.org/uniprot/W5Q078 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:INSL5 ^@ http://purl.uniprot.org/uniprot/A0A836ADC1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DUSP21 ^@ http://purl.uniprot.org/uniprot/A0A6P3YQ13 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NR1I2 ^@ http://purl.uniprot.org/uniprot/W5QEY2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9940:SEC22C ^@ http://purl.uniprot.org/uniprot/W5NZS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/9940:MAPKAP1 ^@ http://purl.uniprot.org/uniprot/Q6QD73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the SIN1 family.|||Cell membrane|||Cytoplasmic vesicle|||Nucleus|||Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts with ATF2, MAP3K2 and MAPK8. Interacts with GTP-bound HRAS and KRAS. Interacts with IFNAR2, NBN and SGK1. Interacts with CCDC28B (By similarity).|||Present in the lumenal epithelium and glandular epithelium of endometrium (at protein level).|||Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (By similarity). http://togogenome.org/gene/9940:SRL ^@ http://purl.uniprot.org/uniprot/A0A6P3ELZ5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:APOC3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EK75 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C3 family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POP5 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE28 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:TMEM203 ^@ http://purl.uniprot.org/uniprot/A0A6P3E208 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC7A8 ^@ http://purl.uniprot.org/uniprot/W5QDJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Membrane http://togogenome.org/gene/9940:ARSK ^@ http://purl.uniprot.org/uniprot/W5Q736 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9940:B3GALT2 ^@ http://purl.uniprot.org/uniprot/W5P4J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9940:NUCKS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YKC9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TBCE ^@ http://purl.uniprot.org/uniprot/A0A6P3T647 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCE family.|||Cytoplasm http://togogenome.org/gene/9940:TMEM230 ^@ http://purl.uniprot.org/uniprot/A0A6P3EIP8|||http://purl.uniprot.org/uniprot/A0A836CXT4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Early endosome|||Endosome|||Involved in trafficking and recycling of synaptic vesicles.|||Late endosome|||Membrane|||Recycling endosome|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Vesicle|||autophagosome|||synaptic vesicle|||trans-Golgi network http://togogenome.org/gene/9940:PELO ^@ http://purl.uniprot.org/uniprot/W5PER0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||Interacts with PINK1, ABCE1 and CNOT4.|||May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs.|||Nucleus http://togogenome.org/gene/9940:PARP4 ^@ http://purl.uniprot.org/uniprot/W5PYD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARTD/PARP family.|||Nucleus http://togogenome.org/gene/9940:PARP1 ^@ http://purl.uniprot.org/uniprot/W5NRR3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARTD/PARP family.|||Chromosome|||Interacts (when auto-poly-ADP-ribosylated) with AIFM1.|||Nucleus|||Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.|||This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. http://togogenome.org/gene/9940:ATP6V1B2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E804 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ATPase alpha/beta chains family.|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits. http://togogenome.org/gene/9940:EIF3D ^@ http://purl.uniprot.org/uniprot/A0A6P3E842|||http://purl.uniprot.org/uniprot/W5QC84 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit D family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Cytoplasm|||Phosphorylated upon DNA damage, probably by ATM or ATR.|||The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. http://togogenome.org/gene/9940:DLC1 ^@ http://purl.uniprot.org/uniprot/W5PJ35 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.|||Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration.|||Membrane|||focal adhesion http://togogenome.org/gene/9940:SERPINA5 ^@ http://purl.uniprot.org/uniprot/A0A6P3EIG5 ^@ Caution|||Similarity ^@ Belongs to the serpin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAM20B ^@ http://purl.uniprot.org/uniprot/A0A6P3EEC4|||http://purl.uniprot.org/uniprot/A0A6P3YKJ8 ^@ Caution|||Similarity ^@ Belongs to the FAM20 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAM219A ^@ http://purl.uniprot.org/uniprot/A0A6P3YFT0 ^@ Caution|||Similarity ^@ Belongs to the FAM219 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EDN3 ^@ http://purl.uniprot.org/uniprot/R9THX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9940:SLC25A38 ^@ http://purl.uniprot.org/uniprot/B2MVX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.|||Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis.|||Mitochondrion inner membrane|||Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis. http://togogenome.org/gene/9940:LOC101120664 ^@ http://purl.uniprot.org/uniprot/W5PRK0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:LNPK ^@ http://purl.uniprot.org/uniprot/W5NPP8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lunapark family.|||Endoplasmic reticulum membrane|||Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.|||Plays a role in determining ER morphology.|||The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. http://togogenome.org/gene/9940:LEXM ^@ http://purl.uniprot.org/uniprot/A0A836APK6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:VCAN ^@ http://purl.uniprot.org/uniprot/W5Q233 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aggrecan/versican proteoglycan family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9940:LOC101119282 ^@ http://purl.uniprot.org/uniprot/W5QC62 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9940:CLIC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3ENU0 ^@ Caution|||Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cell membrane|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane|||Nucleus membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PCOLCE2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E759|||http://purl.uniprot.org/uniprot/W5P7E7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDK5RAP3 ^@ http://purl.uniprot.org/uniprot/W5PCA6 ^@ Similarity ^@ Belongs to the CDK5RAP3 family. http://togogenome.org/gene/9940:LOC443269 ^@ http://purl.uniprot.org/uniprot/A0A836A3D4|||http://purl.uniprot.org/uniprot/W5NYE4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CBWD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9A9 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily. http://togogenome.org/gene/9940:LOC101104613 ^@ http://purl.uniprot.org/uniprot/W5PW15 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Vesicle http://togogenome.org/gene/9940:HTT ^@ http://purl.uniprot.org/uniprot/B7U9A4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the huntingtin family.|||Cytoplasm|||May play a role in microtubule-mediated transport or vesicle function.|||Nucleus http://togogenome.org/gene/9940:TNPO3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E482 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101122332 ^@ http://purl.uniprot.org/uniprot/A0A6P3ESL9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TBCB ^@ http://purl.uniprot.org/uniprot/A0A6P3E9Q7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCB family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TOB2 ^@ http://purl.uniprot.org/uniprot/A0A6P3CXD1|||http://purl.uniprot.org/uniprot/A0A6P7DRZ4 ^@ Caution|||Similarity ^@ Belongs to the BTG family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NOP16 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9G2|||http://purl.uniprot.org/uniprot/W5NVT8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP16 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:ACSM4 ^@ http://purl.uniprot.org/uniprot/W5PTX6 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9940:SGK1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6W0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POLE3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7Q0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101110534 ^@ http://purl.uniprot.org/uniprot/A0A835ZS57 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRPL11 ^@ http://purl.uniprot.org/uniprot/W5P547 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/9940:GBA2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5W7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the non-lysosomal glucosylceramidase family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRR15 ^@ http://purl.uniprot.org/uniprot/I3QHL1 ^@ Similarity ^@ Belongs to the PRR15 family. http://togogenome.org/gene/9940:PTGDS ^@ http://purl.uniprot.org/uniprot/A0A836D2V4|||http://purl.uniprot.org/uniprot/Q9XSM0 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the calycin superfamily. Lipocalin family.|||Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).|||Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.|||Golgi apparatus|||In the male reproductive system, it is expressed in the testis and epididymis, and is secreted into the seminal fluid.|||Membrane|||Monomer.|||Nucleus membrane|||Rough endoplasmic reticulum|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||perinuclear region http://togogenome.org/gene/9940:PON3 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4H3 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C1QTNF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TS36 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAM149B1 ^@ http://purl.uniprot.org/uniprot/W5PC66 ^@ Similarity ^@ Belongs to the FAM149 family. http://togogenome.org/gene/9940:BABAM1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDG9|||http://purl.uniprot.org/uniprot/A0A836D1E5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BABAM1 family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KIF24 ^@ http://purl.uniprot.org/uniprot/W5PHT1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9940:C1H1orf210 ^@ http://purl.uniprot.org/uniprot/A0A6P3TBQ3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DCBLD1 ^@ http://purl.uniprot.org/uniprot/W5PG18 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:GTF2H1 ^@ http://purl.uniprot.org/uniprot/W5PIV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/9940:MRPL9 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZ06|||http://purl.uniprot.org/uniprot/W5QIR3 ^@ Caution|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:B3GALT5 ^@ http://purl.uniprot.org/uniprot/W5Q2B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9940:MPL ^@ http://purl.uniprot.org/uniprot/A0A6P3E4W9 ^@ Caution|||Similarity ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GGPS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGM3|||http://purl.uniprot.org/uniprot/W5NZX6 ^@ Caution|||Similarity ^@ Belongs to the FPP/GGPP synthase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MAP2K2 ^@ http://purl.uniprot.org/uniprot/W5PM87 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9940:DNAJB1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5H5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PPIC ^@ http://purl.uniprot.org/uniprot/W5QC54 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9940:CIB1 ^@ http://purl.uniprot.org/uniprot/A0A836CUH8|||http://purl.uniprot.org/uniprot/B1A8Z2 ^@ Caution|||Domain|||Function|||Miscellaneous|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Apical cell membrane|||Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells (By similarity).|||Cell membrane|||Cytoplasm|||Expressed strongly in testis. Expressed weakly in liver, kidney and spleen.|||Membrane|||Monomer. Interacts with the heterodimeric integrin alpha-IIb/beta3 (ITGA2B-ITGB3). Interacts with ITGA2B (via cytoplasmic domain); the interaction is direct and calcium-dependent. Interacts with the protein kinases PLK2/SNK and PRKDC (via the region immediately upstream of the kinase domain). Interacts with PLK3; the interaction inhibits PLK3 kinase activity. Interacts with PSEN2. Interacts (via C-terminus) with F8. Interacts with NBR1 (via C-terminus). Interacts with FEZ1 (via C-terminus). Interacts with UBR5 (via C-terminus); the interaction is sensitive to DNA damage, and may target CIB1 for ubiquitin-mediated degradation. Interacts with IFI6; the interaction is direct. Interacts with BCL2. Interacts with ITPR3; the interaction occurs in a calcium dependent manner. Interacts with PTK2/FAK1. Interacts with MAP3K5; the interaction inhibits MAP3K5 activation by phosphorylation, and its subsequent interaction with TRAF2. Interacts (via C-terminal region) with STMN2 (via the N-terminal region); the interaction is direct, occurs in a calcium-dependent manner and attenuates the STMN2-induced neurite outgrowth inhibition. Interacts with SPHK1, the interaction occurs in a calcium-dependent manner. Interacts with ITGA2B (via C-terminal cytoplasmic tail); the interaction occurs upon platelet aggregation and is stabilized/increased in a calcium and magnesium-dependent manner. Interacts with PAK1 (via N-terminal region); the interaction is direct and occurs in a calcium-dependent manner. Interacts with RAC3 (via C-terminal region); the interaction induces their association with the cytoskeleton upon alpha-IIb/beta3 integrin-mediated adhesion. Interacts with ITGA5 and ITGAV. Interacts with MYO1C. Interacts with ITGA2B (via C-terminal cytoplasmic tail region). Interacts (via C-terminal region) with PPP3R1; the interaction increases upon cardiomyocytes hypertrophy. Interacts with CACNA1C; the interaction increases upon cardiomyocytes hypertrophy. Interacts with TAS1R2 (via C-terminus); this interaction is independent of the myristoylation state of CIB1 (By similarity). Interacts and forms a complex with TMC6 and TMC8 (By similarity).|||Nucleus|||Perikaryon|||The EF-hands may also bind magnesium ions in the presence of high Mg(2+) levels and low Ca(2+) levels.|||The binding of either calcium or magnesium significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||centrosome|||cytoskeleton|||filopodium tip|||growth cone|||lamellipodium|||neuron projection|||perinuclear region|||ruffle membrane|||sarcolemma http://togogenome.org/gene/9940:GPX5 ^@ http://purl.uniprot.org/uniprot/H9TN93 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9940:STX1B ^@ http://purl.uniprot.org/uniprot/P61268 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the syntaxin family.|||Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca(2+)-dependent (By similarity).|||Membrane|||Phosphorylated by CK2.|||Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity). http://togogenome.org/gene/9940:AMIGO2 ^@ http://purl.uniprot.org/uniprot/A0A836AL07|||http://purl.uniprot.org/uniprot/W5Q8K7 ^@ Caution|||Similarity ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MCM6 ^@ http://purl.uniprot.org/uniprot/W5PLR4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9940:PSMC3 ^@ http://purl.uniprot.org/uniprot/A0A835ZRX0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MAP2K5 ^@ http://purl.uniprot.org/uniprot/W5QAG1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9940:TDGF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EPK3|||http://purl.uniprot.org/uniprot/W5PE44 ^@ Caution|||Similarity ^@ Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POLR2D ^@ http://purl.uniprot.org/uniprot/A0A6P3E645|||http://purl.uniprot.org/uniprot/W5Q389 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCDC196 ^@ http://purl.uniprot.org/uniprot/A0A836D0C3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C4BPB ^@ http://purl.uniprot.org/uniprot/L8E9Q6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:WNT2 ^@ http://purl.uniprot.org/uniprot/Q09YI4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).|||Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.|||Secreted|||extracellular matrix http://togogenome.org/gene/9940:BTN1A1 ^@ http://purl.uniprot.org/uniprot/W5NPT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/9940:PIGV ^@ http://purl.uniprot.org/uniprot/W5P1Z1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGV family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.|||Membrane http://togogenome.org/gene/9940:KRTAP1-3 ^@ http://purl.uniprot.org/uniprot/A0A6P3CWT8|||http://purl.uniprot.org/uniprot/Q7JFW9 ^@ Caution|||Function ^@ The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa).|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EEF1D ^@ http://purl.uniprot.org/uniprot/Q717R8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EF-1-beta/EF-1-delta family.|||EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.|||EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. http://togogenome.org/gene/9940:RAB5B ^@ http://purl.uniprot.org/uniprot/A0A6P3TLQ8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POLR2H ^@ http://purl.uniprot.org/uniprot/A0A6P3E6X1|||http://purl.uniprot.org/uniprot/W5QHC1 ^@ Caution|||Function|||Similarity ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ING4 ^@ http://purl.uniprot.org/uniprot/W5PB26 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9940:NCF4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EB22 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LTA ^@ http://purl.uniprot.org/uniprot/W5PF86 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.|||Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.|||Membrane|||Secreted http://togogenome.org/gene/9940:AFG3L2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EL65 ^@ Caution|||Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DPF2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EPQ1|||http://purl.uniprot.org/uniprot/W5PY56 ^@ Caution|||Similarity ^@ Belongs to the requiem/DPF family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HCRTR2 ^@ http://purl.uniprot.org/uniprot/W5P9D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:IP6K1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YNZ5 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9940:SENP1 ^@ http://purl.uniprot.org/uniprot/W5QDE6 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9940:ENTPD5 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGD5 ^@ Caution|||Similarity ^@ Belongs to the GDA1/CD39 NTPase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TMED5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E457|||http://purl.uniprot.org/uniprot/A0A6P7E6I8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Interacts with TMED9 and TMED10.|||Membrane|||Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cis-Golgi network membrane http://togogenome.org/gene/9940:ARRB1 ^@ http://purl.uniprot.org/uniprot/W5PNY5 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9940:ITGA10 ^@ http://purl.uniprot.org/uniprot/W5QHG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9940:LOC101122148 ^@ http://purl.uniprot.org/uniprot/A0A836ADP7 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ATP6V0A2 ^@ http://purl.uniprot.org/uniprot/W5NXR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/9940:ITPRIPL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E2V1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HNRNPH1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TRT6|||http://purl.uniprot.org/uniprot/A0A6P7E1X5|||http://purl.uniprot.org/uniprot/A0A836D2J1 ^@ Caution|||Subcellular Location Annotation ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleoplasm http://togogenome.org/gene/9940:NR3C1 ^@ http://purl.uniprot.org/uniprot/B0LSR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Mitochondrion|||Nucleus|||centrosome|||spindle http://togogenome.org/gene/9940:GINS1 ^@ http://purl.uniprot.org/uniprot/A0A6P7ERV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS1/PSF1 family.|||Chromosome|||Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.|||Nucleus|||Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/9940:ARL4C ^@ http://purl.uniprot.org/uniprot/A0A6P9FQH7|||http://purl.uniprot.org/uniprot/C5IWU5 ^@ Caution|||Similarity ^@ Belongs to the small GTPase superfamily. Arf family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC13A2 ^@ http://purl.uniprot.org/uniprot/W5QAI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9940:CENPO ^@ http://purl.uniprot.org/uniprot/A0A6P3TAG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-O/MCM21 family.|||Nucleus http://togogenome.org/gene/9940:PPP2R3A ^@ http://purl.uniprot.org/uniprot/A0A6P3YIV7 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101105336 ^@ http://purl.uniprot.org/uniprot/A0A6P3EA32|||http://purl.uniprot.org/uniprot/W5NTE7 ^@ Caution|||Similarity ^@ Belongs to the universal ribosomal protein uL6 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HYLS1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EPH8|||http://purl.uniprot.org/uniprot/A0A6P7D8N1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HYLS1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||centriole|||cilium http://togogenome.org/gene/9940:ADAMTSL4 ^@ http://purl.uniprot.org/uniprot/A0A6P3YII0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MED31 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7T0|||http://purl.uniprot.org/uniprot/W5NSW9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 31 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:YWHAZ ^@ http://purl.uniprot.org/uniprot/H9CJU6 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9940:LOC101119459 ^@ http://purl.uniprot.org/uniprot/A0A6P7DXZ0 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion membrane http://togogenome.org/gene/9940:TP53 ^@ http://purl.uniprot.org/uniprot/P51664 ^@ Cofactor|||Disease Annotation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation of Lys-371 by CREBBP enhances transcriptional activity. Acetylation of Lys-371 by EP300. Deacetylation of Lys-371 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylation by SIRT2 impairs its ability to induce transcription activation in a AKT-dependent manner. Acetylation at Lys-370 increases stability. Deacetylation at Lys-370 by SIRT6 decreases its stability, thereby regulating cell senescence.|||Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Endoplasmic reticulum|||Forms homodimers and homotetramers (By similarity). Binds DNA as a homotetramer. Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1. Interacts with WWOX. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity. Interacts with ARMC10, BANP, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation. Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-371) with L3MBTL1. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with AURKB, SETD2, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2. Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by cyclosporin A (CsA). Interacts with SNAI1; the interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion. Interacts with KAT6A. Interacts with UBC9. Interacts with ZNF385B; the interaction is direct. Interacts (via DNA-binding domain) with ZNF385A; the interaction is direct and enhances p53/TP53 transactivation functions on cell-cycle arrest target genes, resulting in growth arrest (By similarity). Interacts with ANKRD2. Interacts with RFFL and RNF34; involved in p53/TP53 ubiquitination. Interacts with MTA1 and COP1. Interacts with CCAR2 (via N-terminus). Interacts with MORC3. Interacts (via C-terminus) with POU4F2 (via C-terminus). Interacts (via oligomerization region) with NOP53; the interaction is direct and may prevent the MDM2-mediated proteasomal degradation of TP53. Interacts with AFG1L; mediates mitochondrial translocation of TP53. Interacts with UBD (By similarity). Interacts with TAF6 (By similarity). Interacts with C10orf90/FATS; the interaction inhibits binding of TP53 and MDM2 (By similarity). Interacts with NUPR1; interaction is stress-dependent. Forms a complex with EP300 and NUPR1; this complex binds CDKN1A promoter leading to transcriptional induction of CDKN1A (By similarity). Interacts with PRMT5 in response to DNA damage; the interaction is TTC5/STRAP dependent (By similarity). Interacts with PPP1R13L (via SH3 domain and ANK repeats); the interaction inhibits pro-apoptotic activity of p53/TP53 (By similarity). Interacts with PPP1R13B/ASPP1 and TP53BP2/ASPP2; the interactions promotes pro-apoptotic activity (By similarity). When phosphorylated at Ser-15, interacts with DDX3X and gamma-tubulin (By similarity). Interacts with KAT7/HBO1; leading to inhibit histone acetyltransferase activity of KAT7/HBO1 (By similarity). Interacts with S100A4; this interaction promotes TP53 degradation (By similarity). Interacts with TTC5/STRAP; the interaction may result in increased mitochondrial-dependent apoptosis (By similarity). Interacts with NQO1; this interaction is NADH-dependent, stabilizes TP53 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome (By similarity). Interacts with DAZAP2 at TP53 target gene promoters; the interaction is triggered by DNA damage and leads to modulation of the expression of a subset of TP53 target genes, reducing DNA damage-induced cell death by limiting the expression of cell death-mediating TP53 target genes (By similarity). Interacts (via N-terminus) with ZNF768 (via zinc-finger domains); interaction might be facilitated by TP53 oligomerization state (By similarity).|||Mitochondrion matrix|||Monomethylated at Lys-361 by SETD7, leading to stabilization and increased transcriptional activation. Monomethylated at Lys-359 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity. Lys-361 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-359. Dimethylated at Lys-361 by EHMT1 and EHMT2. Monomethylated at Lys-371 by KMT5A, promoting interaction with L3MBTL1 and leading to repress transcriptional activity. Demethylation of dimethylated Lys-359 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation (By similarity). Monomethylated at Arg-322 and dimethylated at Arg-324 and Arg-326 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity (By similarity).|||Nucleus|||PML body|||Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylated on Thr-18 by VRK1, which may prevent the interaction with MDM2. Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2. Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis. Phosphorylated on Ser-33 by CDK7 in a CAK complex in response to DNA damage. Phosphorylated by HIPK1. Phosphorylated on Ser-381 following UV but not gamma irradiation. Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15 and Ser-33, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated at Ser-304 and Ser-381 by CDK2 in response to DNA-damage (By similarity). Phosphorylation at Ser-15 is required for interaction with DDX3X and gamma-tubulin (By similarity).|||Sumoylated with SUMO1. Sumoylated at Lys-375 by UBC9 (By similarity).|||The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase.|||Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. Ubiquitinated by MKRN1, which leads to proteasomal degradation. Deubiquitinated by USP10, leading to stabilize it. Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation. Ubiquitination by TOPORS induces degradation. Deubiquitination by USP7, leading to stabilize it. Ubiquitinated by COP1, which leads to proteasomal degradation (By similarity). Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 (By similarity). Polyubiquitinated by C10orf90/FATS, polyubiquitination is 'Lys-48'-linkage independent and non-proteolytic, leading to TP53 stabilization (By similarity).|||centrosome|||p53 is found in increased amounts in a wide variety of transformed cells. p53 is frequently mutated or inactivated in many types of cancer. http://togogenome.org/gene/9940:SESN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EFT6|||http://purl.uniprot.org/uniprot/W5PM00 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FYN ^@ http://purl.uniprot.org/uniprot/A0A6P3E6N0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9940:BECN1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EHI7|||http://purl.uniprot.org/uniprot/W5P0K1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.|||Belongs to the beclin family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Mitochondrion membrane|||Plays a central role in autophagy.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||autophagosome|||trans-Golgi network membrane http://togogenome.org/gene/9940:CAPN2 ^@ http://purl.uniprot.org/uniprot/A0A6P3CWW1|||http://purl.uniprot.org/uniprot/A8IF71 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C2 family.|||Cell membrane|||Cytoplasm|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CDC25A ^@ http://purl.uniprot.org/uniprot/A0A6P3YNZ8 ^@ Caution|||Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101107724 ^@ http://purl.uniprot.org/uniprot/W5QF97 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:ARHGEF12 ^@ http://purl.uniprot.org/uniprot/W5Q7F5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Membrane http://togogenome.org/gene/9940:AVL9 ^@ http://purl.uniprot.org/uniprot/W5PA78 ^@ Subcellular Location Annotation ^@ Endosome|||Recycling endosome http://togogenome.org/gene/9940:LOC101107541 ^@ http://purl.uniprot.org/uniprot/W5PJY7 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9940:LRP10 ^@ http://purl.uniprot.org/uniprot/A0A6P3E5X6|||http://purl.uniprot.org/uniprot/W5QDQ0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:HAMP ^@ http://purl.uniprot.org/uniprot/E0X9N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hepcidin family.|||Secreted http://togogenome.org/gene/9940:SPRYD4 ^@ http://purl.uniprot.org/uniprot/A0A836D5G0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MAMDC2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E879 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPRD1A ^@ http://purl.uniprot.org/uniprot/A0A6P3EL18|||http://purl.uniprot.org/uniprot/W5P6D8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PXT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3TEF8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MAPK13 ^@ http://purl.uniprot.org/uniprot/B6Z9S6 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Interacts with MAPK8IP2. http://togogenome.org/gene/9940:EIF1AX ^@ http://purl.uniprot.org/uniprot/B9VH02 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. http://togogenome.org/gene/9940:IGF2BP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E515|||http://purl.uniprot.org/uniprot/W5QH89 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||P-body|||Stress granule|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:OCIAD1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6W1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OCIAD1 family.|||Endosome|||Interacts with STAT3.|||Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.|||The OCIA domain is necessary and sufficient for endosomal localization. http://togogenome.org/gene/9940:SFXN1 ^@ http://purl.uniprot.org/uniprot/B2LU20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. May also transport other amino acids including alanine and cysteine.|||Belongs to the sideroflexin family.|||Mitochondrion inner membrane http://togogenome.org/gene/9940:CARHSP1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EE35 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SMYD4 ^@ http://purl.uniprot.org/uniprot/A0A836CYA8 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CALCB ^@ http://purl.uniprot.org/uniprot/B3IWF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcitonin family.|||Secreted|||Stimulates cAMP production via the calcitonin receptor (CT) but not via the CT-like (CL) receptor. http://togogenome.org/gene/9940:SNRPG ^@ http://purl.uniprot.org/uniprot/A0A6P3E742|||http://purl.uniprot.org/uniprot/W5QEL2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||cytosol http://togogenome.org/gene/9940:ANP32A ^@ http://purl.uniprot.org/uniprot/A0A6P3E5U7 ^@ Caution|||Similarity ^@ Belongs to the ANP32 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CAMK2A ^@ http://purl.uniprot.org/uniprot/A0A6P3E9R3|||http://purl.uniprot.org/uniprot/W5PAI9 ^@ Caution|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101111669 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJL4 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ACACA ^@ http://purl.uniprot.org/uniprot/Q28559 ^@ Activity Regulation|||Cofactor|||Domain|||Function|||Induction|||PTM|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Binds 2 magnesium or manganese ions per subunit.|||Consists of an N-terminal biotin carboxylation/carboxylase (BC) domain that catalyzes the ATP-dependent transient carboxylation of the biotin covalently attached to the central biotinyl-binding/biotin carboxyl carrier (BCC) domain. The C-terminal carboxyl transferase (CT) domain catalyzes the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA to produce malonyl-CoA.|||Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.|||Expressed at high levels in mammary gland.|||Induced in mammary gland during lactation.|||Inhibited by phosphorylation (By similarity). Citrate promotes oligomerization of the protein into filaments that correspond to the most active form of the carboxylase (By similarity).|||Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity.|||Phosphorylation at Ser-80 by AMPK inactivates enzyme activity.|||Phosphorylation on Ser-1263 is required for interaction with BRCA1.|||The biotin cofactor is covalently attached to the central biotinyl-binding domain and is required for the catalytic activity.|||cytosol http://togogenome.org/gene/9940:MYSM1 ^@ http://purl.uniprot.org/uniprot/A0A6P3DYB9|||http://purl.uniprot.org/uniprot/A0A6P3TK77 ^@ Caution|||Similarity ^@ Belongs to the peptidase M67A family. MYSM1 subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LYRM2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EGX4|||http://purl.uniprot.org/uniprot/W5PSX8 ^@ Caution|||Similarity ^@ Belongs to the complex I LYR family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LAS1L ^@ http://purl.uniprot.org/uniprot/A0A6P3ERW4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MRPS31 ^@ http://purl.uniprot.org/uniprot/W5PIG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS31 family.|||Mitochondrion http://togogenome.org/gene/9940:GART ^@ http://purl.uniprot.org/uniprot/A0A6P3TRW3 ^@ Similarity ^@ In the C-terminal section; belongs to the GART family.|||In the N-terminal section; belongs to the GARS family.|||In the central section; belongs to the AIR synthase family. http://togogenome.org/gene/9940:ZNF18 ^@ http://purl.uniprot.org/uniprot/A0A6P3TWV3 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CASQ1 ^@ http://purl.uniprot.org/uniprot/W5PF00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/9940:MRPL50 ^@ http://purl.uniprot.org/uniprot/W5PCC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL50 family.|||Mitochondrion http://togogenome.org/gene/9940:RHOJ ^@ http://purl.uniprot.org/uniprot/A0A6P3E7Y1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ECSCR ^@ http://purl.uniprot.org/uniprot/A0A6P3E5Z1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:POU4F3 ^@ http://purl.uniprot.org/uniprot/A0A6P3YJ45|||http://purl.uniprot.org/uniprot/W5NYL1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101120093 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7N8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SRPX2 ^@ http://purl.uniprot.org/uniprot/W5NW55 ^@ Caution|||Subcellular Location Annotation ^@ Cell surface|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Synapse http://togogenome.org/gene/9940:ARL5C ^@ http://purl.uniprot.org/uniprot/A0A6P3CWZ6|||http://purl.uniprot.org/uniprot/A0A6P7EHS6 ^@ Caution|||Similarity ^@ Belongs to the small GTPase superfamily. Arf family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101116441 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6N5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101119277 ^@ http://purl.uniprot.org/uniprot/A0A6P3TGI3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DESI2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJJ9 ^@ Caution|||Similarity ^@ Belongs to the DeSI family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SLC6A4 ^@ http://purl.uniprot.org/uniprot/Q9GMA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.|||Cell membrane|||Endomembrane system|||Endosome membrane|||Membrane|||Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.|||Synapse|||focal adhesion http://togogenome.org/gene/9940:LOC101115597 ^@ http://purl.uniprot.org/uniprot/A0A6P3TXD0|||http://purl.uniprot.org/uniprot/W5NRS4 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RRP8 ^@ http://purl.uniprot.org/uniprot/A0A6P3EAC4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. RRP8 family.|||Component of the eNoSC complex.|||Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||nucleolus http://togogenome.org/gene/9940:ENPP3 ^@ http://purl.uniprot.org/uniprot/W5PXE0 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9940:SLC16A7 ^@ http://purl.uniprot.org/uniprot/A0A6P3E392|||http://purl.uniprot.org/uniprot/A0A6P3TQ29 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Cytoplasm|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AOC2 ^@ http://purl.uniprot.org/uniprot/W5P132 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/9940:C21H11orf54 ^@ http://purl.uniprot.org/uniprot/A0A6P3EP88|||http://purl.uniprot.org/uniprot/A0A6P7D971 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.|||Monomer.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NAV3 ^@ http://purl.uniprot.org/uniprot/W5Q062 ^@ Similarity ^@ Belongs to the Nav/unc-53 family. http://togogenome.org/gene/9940:ADRB2 ^@ http://purl.uniprot.org/uniprot/B3GN12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.|||Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.|||Cell membrane|||Early endosome|||Golgi apparatus|||Membrane http://togogenome.org/gene/9940:NT5C2 ^@ http://purl.uniprot.org/uniprot/A0A835ZS04|||http://purl.uniprot.org/uniprot/W5NYF9 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PRLH ^@ http://purl.uniprot.org/uniprot/A0A836APA5|||http://purl.uniprot.org/uniprot/Q8WN12 ^@ Caution|||Function|||Subcellular Location Annotation|||Tissue Specificity ^@ More abundantly expressed in the brainstem than the hypothalamus.|||Secreted|||Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TLX2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E2S8|||http://purl.uniprot.org/uniprot/W5PT83 ^@ Caution|||Subcellular Location Annotation ^@ Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GJA8 ^@ http://purl.uniprot.org/uniprot/P55917 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ A hemichannel or connexon is composed of a hexamer of connexins. A functional gap junction is formed by the apposition of two hemichannels (PubMed:30542154). Forms heteromeric channels with GJA3 (PubMed:30542154).|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Detected in eye lens (at protein level) (PubMed:30542154). Eye lens (PubMed:8654111).|||Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.|||gap junction http://togogenome.org/gene/9940:STK4 ^@ http://purl.uniprot.org/uniprot/A0A6P3EF43 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MAX ^@ http://purl.uniprot.org/uniprot/A0A6P3TJ07 ^@ Caution|||Similarity ^@ Belongs to the MAX family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CENPL ^@ http://purl.uniprot.org/uniprot/W5PSJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-L/IML3 family.|||Nucleus http://togogenome.org/gene/9940:PTPRA ^@ http://purl.uniprot.org/uniprot/A0A6P3YLZ4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MEAF6 ^@ http://purl.uniprot.org/uniprot/A0A6P3YIL4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EAF6 family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.|||Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||kinetochore|||nucleolus http://togogenome.org/gene/9940:PLEKHO1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YF55 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC105601867 ^@ http://purl.uniprot.org/uniprot/W5PJG0 ^@ Function|||Similarity ^@ Belongs to the SAA family.|||Major acute phase reactant. Apolipoprotein of the HDL complex. http://togogenome.org/gene/9940:COL4A6 ^@ http://purl.uniprot.org/uniprot/W5QAD7 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9940:LOC101121200 ^@ http://purl.uniprot.org/uniprot/W5PBA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9940:SHARPIN ^@ http://purl.uniprot.org/uniprot/A0A6P3EC45 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CCDC25 ^@ http://purl.uniprot.org/uniprot/W5PZL7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC25 family.|||Cell membrane|||Endomembrane system|||Interacts (via cytoplasmic region) with ILK. http://togogenome.org/gene/9940:CCL25 ^@ http://purl.uniprot.org/uniprot/Q1WLQ0 ^@ Similarity ^@ Belongs to the intercrine beta (chemokine CC) family. http://togogenome.org/gene/9940:CYP3A24 ^@ http://purl.uniprot.org/uniprot/A0A835ZU24|||http://purl.uniprot.org/uniprot/Q29496 ^@ Caution|||Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane|||P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MARS1 ^@ http://purl.uniprot.org/uniprot/W5P929 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9940:CNN2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9K2|||http://purl.uniprot.org/uniprot/W5PLD5 ^@ Caution|||Function|||Similarity ^@ Belongs to the calponin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/9940:EEF1AKMT1 ^@ http://purl.uniprot.org/uniprot/A0A6P7EED0|||http://purl.uniprot.org/uniprot/A0A836AAH2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.|||Cytoplasm|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure. http://togogenome.org/gene/9940:PDGFD ^@ http://purl.uniprot.org/uniprot/W5NZA8 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the PDGF/VEGF growth factor family.|||Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:LOC101113221 ^@ http://purl.uniprot.org/uniprot/A0A6P3E105 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm|||podosome http://togogenome.org/gene/9940:C1H3orf70 ^@ http://purl.uniprot.org/uniprot/A0A6P3E6W7 ^@ Caution|||Similarity ^@ Belongs to the UPF0524 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LST1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EPZ5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SAR1B ^@ http://purl.uniprot.org/uniprot/A0A6P3E9L2|||http://purl.uniprot.org/uniprot/W5PXU2 ^@ Caution|||Similarity ^@ Belongs to the small GTPase superfamily. Arf family.|||Belongs to the small GTPase superfamily. SAR1 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SAMM50 ^@ http://purl.uniprot.org/uniprot/A0A6P3E440|||http://purl.uniprot.org/uniprot/W5QD80 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SAM50/omp85 family.|||Mitochondrion outer membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:TEX30 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7I1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MND1 ^@ http://purl.uniprot.org/uniprot/A0A6P3YM90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MND1 family.|||Nucleus|||Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. http://togogenome.org/gene/9940:LOC101108528 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7C4|||http://purl.uniprot.org/uniprot/A0A6P3TVJ9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.|||Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. http://togogenome.org/gene/9940:HPCAL1 ^@ http://purl.uniprot.org/uniprot/A0A6P7DRY4|||http://purl.uniprot.org/uniprot/B3VSB7 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the recoverin family.|||May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.|||Membrane|||Probably binds two or three calcium ions.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NLN ^@ http://purl.uniprot.org/uniprot/W5P7V5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/9940:KCNV1 ^@ http://purl.uniprot.org/uniprot/W5PQQ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.|||Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.|||Membrane|||Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. http://togogenome.org/gene/9940:SCRN3 ^@ http://purl.uniprot.org/uniprot/A0A836D6L5|||http://purl.uniprot.org/uniprot/W5NQ77 ^@ Caution|||Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ALOXE3 ^@ http://purl.uniprot.org/uniprot/W5QBT2 ^@ Caution|||Similarity ^@ Belongs to the lipoxygenase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:FGF10 ^@ http://purl.uniprot.org/uniprot/A0A6P9FN95|||http://purl.uniprot.org/uniprot/Q9N1B9 ^@ Caution|||Similarity ^@ Belongs to the heparin-binding growth factors family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101115964 ^@ http://purl.uniprot.org/uniprot/W5PEQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9940:CAPN3 ^@ http://purl.uniprot.org/uniprot/Q9TTH8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Activated by micromolar concentrations of calcium and inhibited by calpastatin.|||Belongs to the peptidase C2 family.|||Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53.|||Cytoplasm|||Homodimer; via EF-hand domain 4. Interacts with TTN/titin. Interacts with CMYA5; this interaction, which results in CMYA5 proteolysis, may protect CAPN3 from autolysis. Interacts with SIMC1. Interacts with UTP25; the interaction is required for CAPN3 translocation to the nucleolus.|||Skeletal muscle.|||nucleolus http://togogenome.org/gene/9940:RPS21 ^@ http://purl.uniprot.org/uniprot/A0A6P3TTE5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the 40S small ribosomal subunit.|||Endoplasmic reticulum|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/9940:TSPAN6 ^@ http://purl.uniprot.org/uniprot/A0A6P3ESK1|||http://purl.uniprot.org/uniprot/W5NW65 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:C3H12orf60 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4E0 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101112427 ^@ http://purl.uniprot.org/uniprot/P79360 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Secreted http://togogenome.org/gene/9940:KEF53_p02 ^@ http://purl.uniprot.org/uniprot/A0A0E3GL06|||http://purl.uniprot.org/uniprot/O78757 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 6 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9940:FABP5 ^@ http://purl.uniprot.org/uniprot/B9VH00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm http://togogenome.org/gene/9940:EIF3H ^@ http://purl.uniprot.org/uniprot/A0A6P3E950|||http://purl.uniprot.org/uniprot/W5PLY1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit H family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KLHL28 ^@ http://purl.uniprot.org/uniprot/A0A6P3EBX4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MAF1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E734 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAF1 family.|||Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:KIF5A ^@ http://purl.uniprot.org/uniprot/A0A6P3TJZ4|||http://purl.uniprot.org/uniprot/W5P814 ^@ Caution|||Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MTRF1 ^@ http://purl.uniprot.org/uniprot/A0A836AA35|||http://purl.uniprot.org/uniprot/W5PAN4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:JCHAIN ^@ http://purl.uniprot.org/uniprot/A0A6P3EAG2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:DHRS7B ^@ http://purl.uniprot.org/uniprot/A0A6P3TKZ0 ^@ Caution|||Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NUDCD1 ^@ http://purl.uniprot.org/uniprot/A0A836A1E0 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EIF4A1 ^@ http://purl.uniprot.org/uniprot/A0A6P3THY7 ^@ Caution|||Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CYP11B1 ^@ http://purl.uniprot.org/uniprot/P51663 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11-deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).|||Belongs to the cytochrome P450 family.|||Mitochondrion inner membrane http://togogenome.org/gene/9940:PLAU ^@ http://purl.uniprot.org/uniprot/C6GBR3 ^@ Caution|||Function ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. http://togogenome.org/gene/9940:LOC101113001 ^@ http://purl.uniprot.org/uniprot/A0A8N7XJ95 ^@ Caution|||Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Membrane|||Mitochondrion inner membrane|||The Rieske protein is a high potential 2Fe-2S protein.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ENSA ^@ http://purl.uniprot.org/uniprot/A0A6P3E4D8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LPCAT2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EJE1|||http://purl.uniprot.org/uniprot/W5Q9N1 ^@ Caution|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MS4A5 ^@ http://purl.uniprot.org/uniprot/W5PTZ0 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9940:UGT1A3 ^@ http://purl.uniprot.org/uniprot/F1CGV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9940:ICAM1 ^@ http://purl.uniprot.org/uniprot/O97692 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/9940:TRAPPC3 ^@ http://purl.uniprot.org/uniprot/W5QEE5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/9940:LOC101114535 ^@ http://purl.uniprot.org/uniprot/W5P2M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9940:VANGL1 ^@ http://purl.uniprot.org/uniprot/A0A836APY7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FGFR1OP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TQI1|||http://purl.uniprot.org/uniprot/W5QEZ4 ^@ Caution|||Similarity ^@ Belongs to the SIKE family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ANO10 ^@ http://purl.uniprot.org/uniprot/A0A6P3YN03|||http://purl.uniprot.org/uniprot/A0A6P3YRK3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PITX2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDK3|||http://purl.uniprot.org/uniprot/W5NZR7|||http://purl.uniprot.org/uniprot/W5NZR8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:ACAD11 ^@ http://purl.uniprot.org/uniprot/W5PGK3 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9940:ITM2C ^@ http://purl.uniprot.org/uniprot/B3VSC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/9940:BAG2 ^@ http://purl.uniprot.org/uniprot/A0A6P3YN50 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RRP7A ^@ http://purl.uniprot.org/uniprot/A0A6P3EBG5|||http://purl.uniprot.org/uniprot/W5QCE3 ^@ Caution|||Similarity ^@ Belongs to the RRP7 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPL36 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9C5|||http://purl.uniprot.org/uniprot/W5PBV8 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101102105 ^@ http://purl.uniprot.org/uniprot/A0A6P3E4F9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cornifin (SPRR) family.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101104199 ^@ http://purl.uniprot.org/uniprot/A0A6P3TEB4 ^@ Caution|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CD3D ^@ http://purl.uniprot.org/uniprot/A0A836A3J9|||http://purl.uniprot.org/uniprot/P18438 ^@ Caution|||Function|||PTM|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ CD3D is mostly present on T-lymphocytes with its TCR-CD3 partners. Present also in fetal NK-cells.|||Cell membrane|||Membrane|||Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells.|||Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.|||The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. Interacts with coreceptors CD4 and CD8.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EEF1B2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EA03|||http://purl.uniprot.org/uniprot/A0A6P7DWW1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the EF-1-beta/EF-1-delta family.|||EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.|||EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PLEKHB2 ^@ http://purl.uniprot.org/uniprot/A0A6P3E8F6 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BST-2B ^@ http://purl.uniprot.org/uniprot/A0A6P3TDB9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MAP3K14 ^@ http://purl.uniprot.org/uniprot/W5PL35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Cytoplasm|||Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. http://togogenome.org/gene/9940:HAX1 ^@ http://purl.uniprot.org/uniprot/A0A6P3DZ39|||http://purl.uniprot.org/uniprot/W5NW58 ^@ Caution|||Function|||Similarity ^@ Belongs to the HAX1 family.|||Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:PMM2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EQN8|||http://purl.uniprot.org/uniprot/A0A6P3TGC7|||http://purl.uniprot.org/uniprot/W5P5K7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:MNAT1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7X7 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Associates with CDK7 and cyclin H.|||Nucleus|||Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GRIN3A ^@ http://purl.uniprot.org/uniprot/W5PC38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9940:SLC25A14 ^@ http://purl.uniprot.org/uniprot/A0A6P9FQQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9940:LOC101105910 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDX4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UBL3 ^@ http://purl.uniprot.org/uniprot/W5PQV5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9940:ABT1 ^@ http://purl.uniprot.org/uniprot/W5QBC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF2/ABP1 family.|||nucleolus http://togogenome.org/gene/9940:BMP2 ^@ http://purl.uniprot.org/uniprot/A0A6P3EET8 ^@ Caution|||Similarity ^@ Belongs to the TGF-beta family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:FAM126B ^@ http://purl.uniprot.org/uniprot/W5Q5I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM126 family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9940:CDS2 ^@ http://purl.uniprot.org/uniprot/W5Q768 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Membrane http://togogenome.org/gene/9940:TMEM39B ^@ http://purl.uniprot.org/uniprot/A0A6P3E966 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:NFYC ^@ http://purl.uniprot.org/uniprot/A0A6P3T7T4 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:BHMT ^@ http://purl.uniprot.org/uniprot/W5Q723 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 zinc ion per subunit.|||Homotetramer.|||Involved in the regulation of homocysteine metabolism. http://togogenome.org/gene/9940:SLC12A2 ^@ http://purl.uniprot.org/uniprot/A0A6P3TDR7|||http://purl.uniprot.org/uniprot/W5Q867 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9940:LUC7L3 ^@ http://purl.uniprot.org/uniprot/W5NZF3 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9940:CTHRC1 ^@ http://purl.uniprot.org/uniprot/A0A6P3E7B1 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GOLGA5 ^@ http://purl.uniprot.org/uniprot/W5PUW5 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.|||Membrane http://togogenome.org/gene/9940:SAMHD1 ^@ http://purl.uniprot.org/uniprot/W5Q5R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAMHD1 family.|||Chromosome http://togogenome.org/gene/9940:RELL1 ^@ http://purl.uniprot.org/uniprot/A0A6P3EDX6|||http://purl.uniprot.org/uniprot/W5PJ17 ^@ Caution|||Similarity ^@ Belongs to the RELT family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RERG ^@ http://purl.uniprot.org/uniprot/A0A6P3E3E3 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UBE3A ^@ http://purl.uniprot.org/uniprot/A0A6P3TD73|||http://purl.uniprot.org/uniprot/A0A6P3YNJ3 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EIF3M ^@ http://purl.uniprot.org/uniprot/A0A6P3EMK2|||http://purl.uniprot.org/uniprot/W5Q519 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Belongs to the eIF-3 subunit M family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:GUCA2A ^@ http://purl.uniprot.org/uniprot/A0A6P9FQB0|||http://purl.uniprot.org/uniprot/A6YT16 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:CFD ^@ http://purl.uniprot.org/uniprot/A0A6P3TSE6|||http://purl.uniprot.org/uniprot/W5PJ66 ^@ Caution|||Function ^@ Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:AK3 ^@ http://purl.uniprot.org/uniprot/W5PVD4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/9940:IPO8 ^@ http://purl.uniprot.org/uniprot/A0A6P3E3B2 ^@ Caution|||Subcellular Location Annotation ^@ Cytoplasm|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101120446 ^@ http://purl.uniprot.org/uniprot/A0A6P3TBU2 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:EPC1 ^@ http://purl.uniprot.org/uniprot/W5PV36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/9940:TBC1D19 ^@ http://purl.uniprot.org/uniprot/A0A6P3EF11 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:SHMT1 ^@ http://purl.uniprot.org/uniprot/A0A6P7EF41|||http://purl.uniprot.org/uniprot/P35623 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Cytoplasm|||Homotetramer (PubMed:7607226). Identified in complex with ABRAXAS2 and the other subunits of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1.|||In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.|||Interconversion of serine and glycine.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:RPRD1B ^@ http://purl.uniprot.org/uniprot/A0A6P3EJ06|||http://purl.uniprot.org/uniprot/W5QAP8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LAMP5 ^@ http://purl.uniprot.org/uniprot/A0A6P3YPD5|||http://purl.uniprot.org/uniprot/W5PJK0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:LOC101113159 ^@ http://purl.uniprot.org/uniprot/C9EI15 ^@ Function ^@ The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa). http://togogenome.org/gene/9940:CNOT10 ^@ http://purl.uniprot.org/uniprot/W5Q117 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT10 family.|||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9940:LAMA4 ^@ http://purl.uniprot.org/uniprot/A0A6P3TGC1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9940:IL23A ^@ http://purl.uniprot.org/uniprot/D6CIQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9940:UTP3 ^@ http://purl.uniprot.org/uniprot/A0A6P3EF77|||http://purl.uniprot.org/uniprot/W5PD55 ^@ Caution|||Similarity ^@ Belongs to the SAS10 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:UBE2N ^@ http://purl.uniprot.org/uniprot/C5IS99 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9940:B4GALT7 ^@ http://purl.uniprot.org/uniprot/D1H0P5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9940:GHR ^@ http://purl.uniprot.org/uniprot/Q28575 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Cell membrane|||On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2.|||On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain. Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation.|||On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity).|||Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).|||Secreted|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation.|||The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).|||The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.|||The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization. http://togogenome.org/gene/9940:FAM163B ^@ http://purl.uniprot.org/uniprot/W5NYR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/9940:CXCL8 ^@ http://purl.uniprot.org/uniprot/P36925|||http://purl.uniprot.org/uniprot/S5TPE2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.|||Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.|||Homodimer.|||Homodimer. Interacts with TNFAIP6 (via Link domain); this interaction interferes with chemokine binding to glycosaminoglycans.|||Secreted http://togogenome.org/gene/9940:NDUFA2 ^@ http://purl.uniprot.org/uniprot/A0A8N7XJ49 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/9940:METTL5 ^@ http://purl.uniprot.org/uniprot/A0A6P3E9P9 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.