http://togogenome.org/gene/1163748:MARHY_RS11325 ^@ http://purl.uniprot.org/uniprot/H8W938 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the aldolase class II family. MtnB subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). http://togogenome.org/gene/1163748:MARHY_RS04000 ^@ http://purl.uniprot.org/uniprot/H8W6A1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEDS family. MrdB/RodA subfamily.|||Cell inner membrane|||Membrane|||Peptidoglycan polymerase that is essential for cell wall elongation. http://togogenome.org/gene/1163748:MARHY_RS11195 ^@ http://purl.uniprot.org/uniprot/H8W8K0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell inner membrane|||Membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/1163748:MARHY_RS10070 ^@ http://purl.uniprot.org/uniprot/H8W6I5 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Cytoplasm|||Homodimer.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/1163748:MARHY_RS10725 ^@ http://purl.uniprot.org/uniprot/H8W7U2 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS09660 ^@ http://purl.uniprot.org/uniprot/H8W5U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP K family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS04990 ^@ http://purl.uniprot.org/uniprot/H8W887 ^@ Similarity ^@ Belongs to the YjdM family. http://togogenome.org/gene/1163748:MARHY_RS05265 ^@ http://purl.uniprot.org/uniprot/H8W8V3 ^@ Similarity ^@ Belongs to the HIBADH-related family. http://togogenome.org/gene/1163748:MARHY_RS02865 ^@ http://purl.uniprot.org/uniprot/H8W488 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/1163748:MARHY_RS09650 ^@ http://purl.uniprot.org/uniprot/H8W5T9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP M family.|||Cell inner membrane|||Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS15705 ^@ http://purl.uniprot.org/uniprot/H8W5Y1 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2). http://togogenome.org/gene/1163748:MARHY_RS11100 ^@ http://purl.uniprot.org/uniprot/H8W8I0 ^@ Function|||Similarity ^@ Belongs to the NadC/ModD family.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/1163748:MARHY_RS03220 ^@ http://purl.uniprot.org/uniprot/H8W4X3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Cell membrane|||Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. http://togogenome.org/gene/1163748:MARHY_RS02500 ^@ http://purl.uniprot.org/uniprot/H8WEG4 ^@ Function|||Similarity ^@ Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/1163748:MARHY_RS14820 ^@ http://purl.uniprot.org/uniprot/H8WEY2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecB family.|||Cytoplasm|||Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.|||One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. http://togogenome.org/gene/1163748:MARHY_RS11130 ^@ http://purl.uniprot.org/uniprot/H8W8I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS01125 ^@ http://purl.uniprot.org/uniprot/H8WC97 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS11800 ^@ http://purl.uniprot.org/uniprot/H8W9T6 ^@ Activity Regulation|||Caution|||Domain|||Function|||Similarity ^@ Belongs to the GlnD family.|||Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.|||Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity. http://togogenome.org/gene/1163748:MARHY_RS01735 ^@ http://purl.uniprot.org/uniprot/H8WD31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS02265 ^@ http://purl.uniprot.org/uniprot/H8WEB1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase subunit omega family.|||Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1163748:MARHY_RS15015 ^@ http://purl.uniprot.org/uniprot/H8W4L8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter large permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/1163748:MARHY_RS01500 ^@ http://purl.uniprot.org/uniprot/H8WCY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS17425 ^@ http://purl.uniprot.org/uniprot/H8W8S9 ^@ Function|||Subcellular Location Annotation ^@ Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system. http://togogenome.org/gene/1163748:MARHY_RS00705 ^@ http://purl.uniprot.org/uniprot/H8WBK2 ^@ Function|||Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate. http://togogenome.org/gene/1163748:MARHY_RS11760 ^@ http://purl.uniprot.org/uniprot/H8W9S8 ^@ Caution|||Function|||Similarity ^@ Belongs to the DXR family.|||Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS11000 ^@ http://purl.uniprot.org/uniprot/H8W8G2 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/1163748:MARHY_RS00315 ^@ http://purl.uniprot.org/uniprot/H8WAW0 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/1163748:MARHY_RS03880 ^@ http://purl.uniprot.org/uniprot/H8W677 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseB family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/1163748:MARHY_RS09995 ^@ http://purl.uniprot.org/uniprot/H8W6H0 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/1163748:MARHY_RS07835 ^@ http://purl.uniprot.org/uniprot/H8WD98 ^@ Function|||Similarity ^@ Belongs to the aconitase/IPM isomerase family.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. http://togogenome.org/gene/1163748:MARHY_RS01600 ^@ http://purl.uniprot.org/uniprot/H8WD05 ^@ Similarity ^@ Belongs to the MQO family. http://togogenome.org/gene/1163748:MARHY_RS06625 ^@ http://purl.uniprot.org/uniprot/H8WB69 ^@ Function|||Similarity ^@ Belongs to the Dus family. DusA subfamily.|||Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs. http://togogenome.org/gene/1163748:MARHY_RS11420 ^@ http://purl.uniprot.org/uniprot/H8W952 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Homodimer.|||Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. http://togogenome.org/gene/1163748:MARHY_RS12750 ^@ http://purl.uniprot.org/uniprot/H8WBF0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation.|||May be beta-lysylated on the epsilon-amino group of Lys-34 by the combined action of EpmA and EpmB, and then hydroxylated on the C5 position of the same residue by EpmC (if this protein is present). Lysylation is critical for the stimulatory effect of EF-P on peptide-bond formation. The lysylation moiety may extend toward the peptidyltransferase center and stabilize the terminal 3-CCA end of the tRNA. Hydroxylation of the C5 position on Lys-34 may allow additional potential stabilizing hydrogen-bond interactions with the P-tRNA. http://togogenome.org/gene/1163748:MARHY_RS08285 ^@ http://purl.uniprot.org/uniprot/H8WE04 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS06300 ^@ http://purl.uniprot.org/uniprot/H8WAI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliP/MopC/SpaP family.|||Cell membrane|||Membrane|||Plays a role in the flagellum-specific transport system. http://togogenome.org/gene/1163748:MARHY_RS06555 ^@ http://purl.uniprot.org/uniprot/H8WB55 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS16925 ^@ http://purl.uniprot.org/uniprot/H8W815 ^@ Similarity ^@ Belongs to the histone deacetylase family. http://togogenome.org/gene/1163748:MARHY_RS17865 ^@ http://purl.uniprot.org/uniprot/H8W9H9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. RhlE subfamily.|||Cytoplasm|||DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA. http://togogenome.org/gene/1163748:MARHY_RS10735 ^@ http://purl.uniprot.org/uniprot/H8W7U4 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/1163748:MARHY_RS12565 ^@ http://purl.uniprot.org/uniprot/H8WBB3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LptE lipoprotein family.|||Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD.|||Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. http://togogenome.org/gene/1163748:MARHY_RS01625 ^@ http://purl.uniprot.org/uniprot/H8WD09 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS04800 ^@ http://purl.uniprot.org/uniprot/H8W7N5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS00770 ^@ http://purl.uniprot.org/uniprot/H8WBL5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS12515 ^@ http://purl.uniprot.org/uniprot/H8WBA2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.|||Heterodimer composed of CysD, the smaller subunit, and CysN.|||With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD. http://togogenome.org/gene/1163748:MARHY_RS10655 ^@ http://purl.uniprot.org/uniprot/H8W7S7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS02895 ^@ http://purl.uniprot.org/uniprot/H8W495 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1163748:MARHY_RS11745 ^@ http://purl.uniprot.org/uniprot/H8W9S5 ^@ Similarity ^@ Belongs to the Skp family. http://togogenome.org/gene/1163748:MARHY_RS11755 ^@ http://purl.uniprot.org/uniprot/H8W9S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS06570 ^@ http://purl.uniprot.org/uniprot/H8WB58 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrC family.|||Cell membrane|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. http://togogenome.org/gene/1163748:MARHY_RS10075 ^@ http://purl.uniprot.org/uniprot/H8W6I6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 1 lipoyl cofactor covalently.|||E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). http://togogenome.org/gene/1163748:MARHY_RS10755 ^@ http://purl.uniprot.org/uniprot/H8W7U8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.|||Belongs to the AAA ATPase family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Homohexamer.|||In the C-terminal section; belongs to the peptidase M41 family.|||In the central section; belongs to the AAA ATPase family. http://togogenome.org/gene/1163748:MARHY_RS06255 ^@ http://purl.uniprot.org/uniprot/H8WAH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FliJ family.|||Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS02450 ^@ http://purl.uniprot.org/uniprot/H8WEF4 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/1163748:MARHY_RS14665 ^@ http://purl.uniprot.org/uniprot/H8WEV1 ^@ Cofactor|||Similarity ^@ Belongs to the WrbA family.|||Binds 1 FMN per monomer. http://togogenome.org/gene/1163748:MARHY_RS02120 ^@ http://purl.uniprot.org/uniprot/H8WDR9 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/1163748:MARHY_RS11740 ^@ http://purl.uniprot.org/uniprot/H8W9S4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the transferase hexapeptide repeat family. LpxD subfamily.|||Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.|||Homotrimer. http://togogenome.org/gene/1163748:MARHY_RS05940 ^@ http://purl.uniprot.org/uniprot/H8W9Q6 ^@ Similarity ^@ Belongs to the glycerate kinase type-1 family. http://togogenome.org/gene/1163748:MARHY_RS01805 ^@ http://purl.uniprot.org/uniprot/H8WDK4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. UvrD subfamily.|||Homodimer.|||Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. http://togogenome.org/gene/1163748:MARHY_RS00275 ^@ http://purl.uniprot.org/uniprot/H8WAV2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS10430 ^@ http://purl.uniprot.org/uniprot/H8W768 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS04095 ^@ http://purl.uniprot.org/uniprot/H8W6C1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6. http://togogenome.org/gene/1163748:MARHY_RS01880 ^@ http://purl.uniprot.org/uniprot/H8WDM0 ^@ Similarity|||Subunit ^@ Belongs to the MoaE family.|||Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis. http://togogenome.org/gene/1163748:MARHY_RS12985 ^@ http://purl.uniprot.org/uniprot/H8WC07 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MscS (TC 1.A.23) family.|||Cell inner membrane|||Homoheptamer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. http://togogenome.org/gene/1163748:MARHY_RS11255 ^@ http://purl.uniprot.org/uniprot/H8W8L2 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/1163748:MARHY_RS00835 ^@ http://purl.uniprot.org/uniprot/H8WBM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS01360 ^@ http://purl.uniprot.org/uniprot/H8WCE5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1163748:MARHY_RS12705 ^@ http://purl.uniprot.org/uniprot/H8WBE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsaE family.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS08415 ^@ http://purl.uniprot.org/uniprot/H8WEJ2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase H family.|||Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS15095 ^@ http://purl.uniprot.org/uniprot/H8W4N4 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/1163748:MARHY_RS00795 ^@ http://purl.uniprot.org/uniprot/H8WBM0 ^@ Similarity ^@ Belongs to the long-chain O-acyltransferase family. http://togogenome.org/gene/1163748:MARHY_RS11250 ^@ http://purl.uniprot.org/uniprot/H8W8L1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsB family.|||Cell inner membrane|||Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.|||Part of a complex composed of FtsB, FtsL and FtsQ. http://togogenome.org/gene/1163748:MARHY_RS10065 ^@ http://purl.uniprot.org/uniprot/H8W6I4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/1163748:MARHY_RS11375 ^@ http://purl.uniprot.org/uniprot/H8W948 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS10215 ^@ http://purl.uniprot.org/uniprot/H8W725 ^@ Similarity ^@ Belongs to the YfgM family. http://togogenome.org/gene/1163748:MARHY_RS03535 ^@ http://purl.uniprot.org/uniprot/H8W5J8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspH family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. http://togogenome.org/gene/1163748:MARHY_RS10245 ^@ http://purl.uniprot.org/uniprot/H8W731 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NDK family.|||Cytoplasm|||Homotetramer.|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/1163748:MARHY_RS15815 ^@ http://purl.uniprot.org/uniprot/H8W604 ^@ Function|||Similarity|||Subunit ^@ Belongs to the serine/threonine dehydratase family.|||Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.|||Homotetramer. http://togogenome.org/gene/1163748:MARHY_RS03725 ^@ http://purl.uniprot.org/uniprot/H8W646 ^@ Similarity ^@ Belongs to the GST superfamily. HSP26 family. http://togogenome.org/gene/1163748:MARHY_RS12460 ^@ http://purl.uniprot.org/uniprot/H8WAS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers. http://togogenome.org/gene/1163748:MARHY_RS03030 ^@ http://purl.uniprot.org/uniprot/H8W4T4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. http://togogenome.org/gene/1163748:MARHY_RS07355 ^@ http://purl.uniprot.org/uniprot/H8WCJ0 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/1163748:MARHY_RS09325 ^@ http://purl.uniprot.org/uniprot/H8W561 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/1163748:MARHY_RS01095 ^@ http://purl.uniprot.org/uniprot/H8WC91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS12755 ^@ http://purl.uniprot.org/uniprot/H8WBF1 ^@ Similarity ^@ Belongs to the radical SAM superfamily. KamA family. http://togogenome.org/gene/1163748:MARHY_RS16790 ^@ http://purl.uniprot.org/uniprot/H8W7Y8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MscS (TC 1.A.23) family.|||Cell inner membrane|||Homoheptamer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS12235 ^@ http://purl.uniprot.org/uniprot/H8WAM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A24 family.|||Cell inner membrane|||Cell membrane|||Membrane|||Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine. http://togogenome.org/gene/1163748:MARHY_RS07515 ^@ http://purl.uniprot.org/uniprot/H8WCM3 ^@ Caution|||Function|||Similarity ^@ Belongs to the LpxK family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). http://togogenome.org/gene/1163748:MARHY_RS11495 ^@ http://purl.uniprot.org/uniprot/H8W966 ^@ Function|||Similarity ^@ Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/1163748:MARHY_RS04960 ^@ http://purl.uniprot.org/uniprot/H8W879 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS06425 ^@ http://purl.uniprot.org/uniprot/H8WB28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmB/CycW/HelB family.|||Cell inner membrane|||Membrane|||Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. http://togogenome.org/gene/1163748:MARHY_RS11075 ^@ http://purl.uniprot.org/uniprot/H8W8H4 ^@ Similarity ^@ Belongs to the Cob(I)alamin adenosyltransferase family. http://togogenome.org/gene/1163748:MARHY_RS11225 ^@ http://purl.uniprot.org/uniprot/H8W8K6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.|||Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS07500 ^@ http://purl.uniprot.org/uniprot/H8WCM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS09475 ^@ http://purl.uniprot.org/uniprot/H8W5Q3 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/1163748:MARHY_RS08815 ^@ http://purl.uniprot.org/uniprot/H8W4C4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.|||Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS12550 ^@ http://purl.uniprot.org/uniprot/H8WBA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.|||Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.|||Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS05555 ^@ http://purl.uniprot.org/uniprot/H8W917 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS02485 ^@ http://purl.uniprot.org/uniprot/H8WEG1 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pantothenate synthetase family.|||Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.|||Cytoplasm|||Homodimer.|||The reaction proceeds by a bi uni uni bi ping pong mechanism. http://togogenome.org/gene/1163748:MARHY_RS06600 ^@ http://purl.uniprot.org/uniprot/H8WB64 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS11070 ^@ http://purl.uniprot.org/uniprot/H8W8H3 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/1163748:MARHY_RS00035 ^@ http://purl.uniprot.org/uniprot/H8WA86 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1163748:MARHY_RS03645 ^@ http://purl.uniprot.org/uniprot/H8W5M1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MsrQ family.|||Binds 1 FMN per subunit.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|||Cell membrane|||Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).|||Membrane|||Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain. http://togogenome.org/gene/1163748:MARHY_RS01465 ^@ http://purl.uniprot.org/uniprot/H8WCX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS01535 ^@ http://purl.uniprot.org/uniprot/H8WCZ2 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/1163748:MARHY_RS02695 ^@ http://purl.uniprot.org/uniprot/H8W457 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A monovalent cation. Ammonium or potassium.|||Belongs to the type III pantothenate kinase family.|||Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS08260 ^@ http://purl.uniprot.org/uniprot/H8WDZ8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/1163748:MARHY_RS18720 ^@ http://purl.uniprot.org/uniprot/H8WEK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dsrC/tusE family.|||Cytoplasm|||Part of a sulfur-relay system. http://togogenome.org/gene/1163748:MARHY_RS11065 ^@ http://purl.uniprot.org/uniprot/H8W8H2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/1163748:MARHY_RS01715 ^@ http://purl.uniprot.org/uniprot/H8WD28 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/1163748:MARHY_RS00245 ^@ http://purl.uniprot.org/uniprot/H8WAU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Cell membrane|||Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS11945 ^@ http://purl.uniprot.org/uniprot/H8W9W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FliS family.|||cytosol http://togogenome.org/gene/1163748:MARHY_RS10650 ^@ http://purl.uniprot.org/uniprot/H8W7S6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.|||Cell membrane|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS02345 ^@ http://purl.uniprot.org/uniprot/H8WED0 ^@ Similarity ^@ Belongs to the SOS response-associated peptidase family. http://togogenome.org/gene/1163748:MARHY_RS13460 ^@ http://purl.uniprot.org/uniprot/H8WCS1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS10540 ^@ http://purl.uniprot.org/uniprot/H8W7Q4 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/1163748:MARHY_RS00060 ^@ http://purl.uniprot.org/uniprot/H8WA91 ^@ Function|||Similarity|||Subunit ^@ A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.|||Belongs to the RecC family.|||Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. http://togogenome.org/gene/1163748:MARHY_RS06280 ^@ http://purl.uniprot.org/uniprot/H8WAH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FliL family.|||Cell inner membrane|||Controls the rotational direction of flagella during chemotaxis.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS07335 ^@ http://purl.uniprot.org/uniprot/H8WCI6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.|||Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS12520 ^@ http://purl.uniprot.org/uniprot/H8WBA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YejK family.|||nucleoid http://togogenome.org/gene/1163748:MARHY_RS05875 ^@ http://purl.uniprot.org/uniprot/H8W9N9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS12000 ^@ http://purl.uniprot.org/uniprot/H8W9X6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum|||Belongs to the bacterial flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.|||Secreted http://togogenome.org/gene/1163748:MARHY_RS14335 ^@ http://purl.uniprot.org/uniprot/H8WE76 ^@ Similarity ^@ Belongs to the long-chain O-acyltransferase family. http://togogenome.org/gene/1163748:MARHY_RS18255 ^@ http://purl.uniprot.org/uniprot/H8WA71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Cell membrane|||Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS03515 ^@ http://purl.uniprot.org/uniprot/H8W5J4 ^@ Function|||Similarity ^@ Belongs to the ribF family.|||Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD. http://togogenome.org/gene/1163748:MARHY_RS10375 ^@ http://purl.uniprot.org/uniprot/H8W757 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.|||Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS14185 ^@ http://purl.uniprot.org/uniprot/H8WE46 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the class II fructose-bisphosphate aldolase family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.|||Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.|||One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/1163748:MARHY_RS06585 ^@ http://purl.uniprot.org/uniprot/H8WB61 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrF family.|||Binds 1 [2Fe-2S] cluster.|||Cell membrane|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway. http://togogenome.org/gene/1163748:MARHY_RS08095 ^@ http://purl.uniprot.org/uniprot/H8WDW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS09965 ^@ http://purl.uniprot.org/uniprot/H8W6G4 ^@ Function ^@ Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. http://togogenome.org/gene/1163748:MARHY_RS01695 ^@ http://purl.uniprot.org/uniprot/H8WD24 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HsdR family.|||Subunit R is required for both nuclease and ATPase activities, but not for modification.|||The type I restriction/modification system is composed of three polypeptides R, M and S. http://togogenome.org/gene/1163748:MARHY_RS15080 ^@ http://purl.uniprot.org/uniprot/H8W4N1 ^@ Function|||Similarity ^@ Belongs to the aldehyde dehydrogenase family. AstD subfamily.|||Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. http://togogenome.org/gene/1163748:MARHY_RS09895 ^@ http://purl.uniprot.org/uniprot/H8W6E9 ^@ Similarity ^@ Belongs to the UPF0065 (bug) family. http://togogenome.org/gene/1163748:MARHY_RS11960 ^@ http://purl.uniprot.org/uniprot/H8W9W8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum|||Belongs to the bacterial flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.|||Secreted http://togogenome.org/gene/1163748:MARHY_RS12080 ^@ http://purl.uniprot.org/uniprot/H8W9Z4 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. http://togogenome.org/gene/1163748:MARHY_RS06575 ^@ http://purl.uniprot.org/uniprot/H8WB59 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell membrane|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||Membrane|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. http://togogenome.org/gene/1163748:MARHY_RS10090 ^@ http://purl.uniprot.org/uniprot/H8W6I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS16905 ^@ http://purl.uniprot.org/uniprot/H8W811 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/1163748:MARHY_RS16170 ^@ http://purl.uniprot.org/uniprot/H8W6N9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lipase chaperone family.|||Cell inner membrane|||May be involved in the folding of the extracellular lipase during its passage through the periplasm. http://togogenome.org/gene/1163748:MARHY_RS05510 ^@ http://purl.uniprot.org/uniprot/H8W908 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS11895 ^@ http://purl.uniprot.org/uniprot/H8W9V5 ^@ Similarity ^@ Belongs to the VgrG protein family. http://togogenome.org/gene/1163748:MARHY_RS04320 ^@ http://purl.uniprot.org/uniprot/H8W6X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS07445 ^@ http://purl.uniprot.org/uniprot/H8WCK9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the L/F-transferase family.|||Cytoplasm|||Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. http://togogenome.org/gene/1163748:MARHY_RS01100 ^@ http://purl.uniprot.org/uniprot/H8WC92 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS06435 ^@ http://purl.uniprot.org/uniprot/H8WB30 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmD/CycX/HelD family.|||Cell inner membrane|||Membrane|||Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. http://togogenome.org/gene/1163748:MARHY_RS02470 ^@ http://purl.uniprot.org/uniprot/H8WEF8 ^@ Function|||Similarity ^@ Belongs to the DHNA family.|||Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. http://togogenome.org/gene/1163748:MARHY_RS08635 ^@ http://purl.uniprot.org/uniprot/H8WEN7 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/1163748:MARHY_RS10000 ^@ http://purl.uniprot.org/uniprot/H8W6H1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.|||Cytoplasm|||In the C-terminal section; belongs to the DAO family.|||In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family. http://togogenome.org/gene/1163748:MARHY_RS07090 ^@ http://purl.uniprot.org/uniprot/H8WBX2 ^@ Cofactor|||Similarity ^@ Belongs to the ApbE family.|||Magnesium. Can also use manganese. http://togogenome.org/gene/1163748:MARHY_RS15680 ^@ http://purl.uniprot.org/uniprot/H8W5X6 ^@ Subcellular Location Annotation ^@ Cell outer membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS07025 ^@ http://purl.uniprot.org/uniprot/H8WBV8 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/1163748:MARHY_RS08330 ^@ http://purl.uniprot.org/uniprot/H8WE13 ^@ Function|||Similarity|||Subunit ^@ Belongs to the trans-sulfuration enzymes family. MetZ subfamily.|||Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.|||Homotetramer. http://togogenome.org/gene/1163748:MARHY_RS16070 ^@ http://purl.uniprot.org/uniprot/H8W6L9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter large permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/1163748:MARHY_RS10525 ^@ http://purl.uniprot.org/uniprot/H8W789 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS06250 ^@ http://purl.uniprot.org/uniprot/H8WAH1 ^@ Similarity ^@ Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily. http://togogenome.org/gene/1163748:MARHY_RS02630 ^@ http://purl.uniprot.org/uniprot/H8W446 ^@ Function|||Similarity ^@ Belongs to the anhydro-N-acetylmuramic acid kinase family.|||Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. http://togogenome.org/gene/1163748:MARHY_RS07060 ^@ http://purl.uniprot.org/uniprot/H8WBW6 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/1163748:MARHY_RS11175 ^@ http://purl.uniprot.org/uniprot/H8W8J6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.|||Binds 3 [4Fe-4S] clusters.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/1163748:MARHY_RS07825 ^@ http://purl.uniprot.org/uniprot/H8WD96 ^@ Function|||Similarity|||Subunit ^@ Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.|||Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.|||Homotetramer; dimer of dimers.|||Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate. http://togogenome.org/gene/1163748:MARHY_RS03505 ^@ http://purl.uniprot.org/uniprot/H8W5J1 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/1163748:MARHY_RS08030 ^@ http://purl.uniprot.org/uniprot/H8WDV1 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/1163748:MARHY_RS07680 ^@ http://purl.uniprot.org/uniprot/H8WD66 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48 family. BepA subfamily.|||Binds 1 zinc ion per subunit.|||Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state.|||Periplasm http://togogenome.org/gene/1163748:MARHY_RS04730 ^@ http://purl.uniprot.org/uniprot/H8W7M1 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.|||Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA. http://togogenome.org/gene/1163748:MARHY_RS07010 ^@ http://purl.uniprot.org/uniprot/H8WBV4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/1163748:MARHY_RS01610 ^@ http://purl.uniprot.org/uniprot/H8WD07 ^@ Cofactor|||PTM|||Subcellular Location Annotation ^@ Binds 2 heme groups per subunit.|||Binds 2 heme groups.|||Periplasm http://togogenome.org/gene/1163748:MARHY_RS14650 ^@ http://purl.uniprot.org/uniprot/H8WEU8 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/1163748:MARHY_RS10285 ^@ http://purl.uniprot.org/uniprot/H8W739 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YajC family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS16285 ^@ http://purl.uniprot.org/uniprot/H8W6R3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS15020 ^@ http://purl.uniprot.org/uniprot/H8W4L9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter small permease family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/1163748:MARHY_RS03995 ^@ http://purl.uniprot.org/uniprot/H8W6A0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transpeptidase family. MrdA subfamily.|||Catalyzes cross-linking of the peptidoglycan cell wall.|||Cell inner membrane http://togogenome.org/gene/1163748:MARHY_RS18195 ^@ http://purl.uniprot.org/uniprot/H8WA59 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS10700 ^@ http://purl.uniprot.org/uniprot/H8W7T6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial histone-like protein family.|||Heterodimer of an alpha and a beta chain.|||This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. http://togogenome.org/gene/1163748:MARHY_RS16785 ^@ http://purl.uniprot.org/uniprot/H8W7Y7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SelU family.|||Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS05630 ^@ http://purl.uniprot.org/uniprot/H8W933 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/1163748:MARHY_RS11270 ^@ http://purl.uniprot.org/uniprot/H8W8L5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA(Ile)-lysidine synthase family.|||Cytoplasm|||Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.|||The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding. http://togogenome.org/gene/1163748:MARHY_RS00200 ^@ http://purl.uniprot.org/uniprot/H8WAB8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/1163748:MARHY_RS15765 ^@ http://purl.uniprot.org/uniprot/H8W5Z3 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/1163748:MARHY_RS00535 ^@ http://purl.uniprot.org/uniprot/H8WB08 ^@ Similarity ^@ Belongs to the YkuD family. http://togogenome.org/gene/1163748:MARHY_RS12480 ^@ http://purl.uniprot.org/uniprot/H8WAS6 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/1163748:MARHY_RS06975 ^@ http://purl.uniprot.org/uniprot/H8WBV1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS10550 ^@ http://purl.uniprot.org/uniprot/H8W7Q6 ^@ Caution|||Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the peroxidase family. Peroxidase/catalase subfamily.|||Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.|||Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.|||Homodimer or homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS06840 ^@ http://purl.uniprot.org/uniprot/H8WBS4 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/1163748:MARHY_RS10690 ^@ http://purl.uniprot.org/uniprot/H8W7T4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LapB family.|||Cell inner membrane|||Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane. http://togogenome.org/gene/1163748:MARHY_RS00870 ^@ http://purl.uniprot.org/uniprot/H8WBN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB family.|||Cell inner membrane http://togogenome.org/gene/1163748:MARHY_RS12695 ^@ http://purl.uniprot.org/uniprot/H8WBD9 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/1163748:MARHY_RS17815 ^@ http://purl.uniprot.org/uniprot/H8W9G9 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/1163748:MARHY_RS02240 ^@ http://purl.uniprot.org/uniprot/H8WEA6 ^@ Cofactor ^@ Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/1163748:MARHY_RS17380 ^@ http://purl.uniprot.org/uniprot/H8W8S0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.|||Membrane|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule. http://togogenome.org/gene/1163748:MARHY_RS07315 ^@ http://purl.uniprot.org/uniprot/H8WCI1 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/1163748:MARHY_RS04375 ^@ http://purl.uniprot.org/uniprot/H8W6Y6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MinC family.|||Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.|||Interacts with MinD and FtsZ. http://togogenome.org/gene/1163748:MARHY_RS17365 ^@ http://purl.uniprot.org/uniprot/H8W8R7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoH subfamily.|||Cytoplasm|||Interacts with the RNA polymerase core enzyme.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. http://togogenome.org/gene/1163748:MARHY_RS04245 ^@ http://purl.uniprot.org/uniprot/H8W6W0 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Belongs to the DNA photolyase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/1163748:MARHY_RS13095 ^@ http://purl.uniprot.org/uniprot/H8WC30 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS05250 ^@ http://purl.uniprot.org/uniprot/H8W8E1 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS11545 ^@ http://purl.uniprot.org/uniprot/H8W976 ^@ Similarity ^@ Belongs to the histone deacetylase family. http://togogenome.org/gene/1163748:MARHY_RS00360 ^@ http://purl.uniprot.org/uniprot/H8WAX1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter small permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/1163748:MARHY_RS17740 ^@ http://purl.uniprot.org/uniprot/H8W9F4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Bcr/CmlA family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS03975 ^@ http://purl.uniprot.org/uniprot/H8W696 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyl phosphate reductase family.|||Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS12230 ^@ http://purl.uniprot.org/uniprot/H8WAM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS11725 ^@ http://purl.uniprot.org/uniprot/H8W9S1 ^@ Function|||Similarity ^@ Belongs to the LpxB family.|||Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. http://togogenome.org/gene/1163748:MARHY_RS12930 ^@ http://purl.uniprot.org/uniprot/H8WBZ5 ^@ Function|||Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate. http://togogenome.org/gene/1163748:MARHY_RS13730 ^@ http://purl.uniprot.org/uniprot/H8WDD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS00390 ^@ http://purl.uniprot.org/uniprot/H8WAX7 ^@ Similarity ^@ Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. http://togogenome.org/gene/1163748:MARHY_RS12385 ^@ http://purl.uniprot.org/uniprot/H8WAQ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LptA family.|||Component of the lipopolysaccharide transport and assembly complex.|||Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.|||Periplasm http://togogenome.org/gene/1163748:MARHY_RS08375 ^@ http://purl.uniprot.org/uniprot/H8WEI3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. http://togogenome.org/gene/1163748:MARHY_RS12260 ^@ http://purl.uniprot.org/uniprot/H8WAN3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DNA gyrase inhibitor YacG family.|||Binds 1 zinc ion.|||Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.|||Interacts with GyrB. http://togogenome.org/gene/1163748:MARHY_RS07205 ^@ http://purl.uniprot.org/uniprot/H8WCF8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS16840 ^@ http://purl.uniprot.org/uniprot/H8W7Z8 ^@ Similarity ^@ Belongs to the acyl coenzyme A hydrolase family. http://togogenome.org/gene/1163748:MARHY_RS08385 ^@ http://purl.uniprot.org/uniprot/H8WEI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS11320 ^@ http://purl.uniprot.org/uniprot/H8W937 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the acireductone dioxygenase (ARD) family.|||Binds 1 Fe(2+) cation per monomer.|||Binds 1 nickel ion per monomer.|||Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS06235 ^@ http://purl.uniprot.org/uniprot/H8WAG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the FliF family.|||Membrane|||The M ring may be actively involved in energy transduction.|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively. http://togogenome.org/gene/1163748:MARHY_RS01990 ^@ http://purl.uniprot.org/uniprot/H8WDP2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerC subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/1163748:MARHY_RS07410 ^@ http://purl.uniprot.org/uniprot/H8WCK1 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/1163748:MARHY_RS17805 ^@ http://purl.uniprot.org/uniprot/H8W9G7 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS11915 ^@ http://purl.uniprot.org/uniprot/H8W9V9 ^@ Function|||Similarity ^@ Belongs to the SELO family.|||Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). http://togogenome.org/gene/1163748:MARHY_RS14750 ^@ http://purl.uniprot.org/uniprot/H8WEW8 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/1163748:MARHY_RS09155 ^@ http://purl.uniprot.org/uniprot/H8W520 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS15285 ^@ http://purl.uniprot.org/uniprot/H8W583 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapB family.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. http://togogenome.org/gene/1163748:MARHY_RS06985 ^@ http://purl.uniprot.org/uniprot/H8WBV3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS02735 ^@ http://purl.uniprot.org/uniprot/H8W461 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS09600 ^@ http://purl.uniprot.org/uniprot/H8W5S9 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS06855 ^@ http://purl.uniprot.org/uniprot/H8WBS7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/1163748:MARHY_RS06730 ^@ http://purl.uniprot.org/uniprot/H8WB91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS13575 ^@ http://purl.uniprot.org/uniprot/H8WCU4 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/1163748:MARHY_RS16985 ^@ http://purl.uniprot.org/uniprot/H8W828 ^@ Similarity ^@ Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily. http://togogenome.org/gene/1163748:MARHY_RS14865 ^@ http://purl.uniprot.org/uniprot/H8W4I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS15855 ^@ http://purl.uniprot.org/uniprot/H8W614 ^@ Function ^@ This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/1163748:MARHY_RS11720 ^@ http://purl.uniprot.org/uniprot/H8W9S0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/1163748:MARHY_RS03690 ^@ http://purl.uniprot.org/uniprot/H8W5M7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.|||Cytoplasm|||Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. http://togogenome.org/gene/1163748:MARHY_RS12805 ^@ http://purl.uniprot.org/uniprot/H8WBG1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS07165 ^@ http://purl.uniprot.org/uniprot/H8WBY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS10350 ^@ http://purl.uniprot.org/uniprot/H8W752 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family.|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each. http://togogenome.org/gene/1163748:MARHY_RS05725 ^@ http://purl.uniprot.org/uniprot/H8W9K8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS11940 ^@ http://purl.uniprot.org/uniprot/H8W9W4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/1163748:MARHY_RS07405 ^@ http://purl.uniprot.org/uniprot/H8WCK0 ^@ Similarity|||Subunit ^@ Belongs to the Nudix hydrolase family. NudJ subfamily.|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS10495 ^@ http://purl.uniprot.org/uniprot/H8W782 ^@ Similarity ^@ Belongs to the nitroreductase family. http://togogenome.org/gene/1163748:MARHY_RS08245 ^@ http://purl.uniprot.org/uniprot/H8WDZ4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Homotetramer.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/1163748:MARHY_RS01135 ^@ http://purl.uniprot.org/uniprot/H8WC99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GtrA family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS05910 ^@ http://purl.uniprot.org/uniprot/H8W9P9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1163748:MARHY_RS15225 ^@ http://purl.uniprot.org/uniprot/H8W4R0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/1163748:MARHY_RS13785 ^@ http://purl.uniprot.org/uniprot/H8WDE9 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/1163748:MARHY_RS07805 ^@ http://purl.uniprot.org/uniprot/H8WD92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OpgD/OpgG family.|||Periplasm http://togogenome.org/gene/1163748:MARHY_RS12715 ^@ http://purl.uniprot.org/uniprot/H8WBE3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueG family.|||Binds 2 [4Fe-4S] clusters per monomer.|||Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS10110 ^@ http://purl.uniprot.org/uniprot/H8W6J4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1163748:MARHY_RS13130 ^@ http://purl.uniprot.org/uniprot/H8WC37 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS11050 ^@ http://purl.uniprot.org/uniprot/H8W8G9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LptF/LptG family.|||Cell inner membrane|||Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).|||Membrane|||Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. http://togogenome.org/gene/1163748:MARHY_RS04765 ^@ http://purl.uniprot.org/uniprot/H8W7M8 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS04455 ^@ http://purl.uniprot.org/uniprot/H8W702 ^@ Activity Regulation|||Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Inhibited by fructose 1,6-bisphosphate (FBP).|||Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate. http://togogenome.org/gene/1163748:MARHY_RS03100 ^@ http://purl.uniprot.org/uniprot/H8W4U9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. KdkA/RfaP family.|||Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS04690 ^@ http://purl.uniprot.org/uniprot/H8W7L3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS04890 ^@ http://purl.uniprot.org/uniprot/H8W864 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS06400 ^@ http://purl.uniprot.org/uniprot/H8WAK1 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/1163748:MARHY_RS03290 ^@ http://purl.uniprot.org/uniprot/H8W4Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PEP-utilizing enzyme family.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS11790 ^@ http://purl.uniprot.org/uniprot/H8W9T4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/1163748:MARHY_RS17375 ^@ http://purl.uniprot.org/uniprot/H8W8R9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Homodimer. Forms a membrane-associated complex with FtsX.|||Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring. http://togogenome.org/gene/1163748:MARHY_RS18315 ^@ http://purl.uniprot.org/uniprot/H8WAT6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PhyH family. EctD subfamily.|||Homodimer.|||Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine. http://togogenome.org/gene/1163748:MARHY_RS16075 ^@ http://purl.uniprot.org/uniprot/H8W6M0 ^@ Similarity ^@ Belongs to the CFA/CMAS family. http://togogenome.org/gene/1163748:MARHY_RS09665 ^@ http://purl.uniprot.org/uniprot/H8W5U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP J family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS04505 ^@ http://purl.uniprot.org/uniprot/H8W7H2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.|||Belongs to the RimM family.|||Binds ribosomal protein uS19.|||Cytoplasm|||The PRC barrel domain binds ribosomal protein uS19. http://togogenome.org/gene/1163748:MARHY_RS16955 ^@ http://purl.uniprot.org/uniprot/H8W821 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcA family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||nucleolus http://togogenome.org/gene/1163748:MARHY_RS07030 ^@ http://purl.uniprot.org/uniprot/H8WBV9 ^@ Similarity|||Subunit ^@ Belongs to the bacterial histone-like protein family.|||Heterodimer of an alpha and a beta chain. http://togogenome.org/gene/1163748:MARHY_RS11295 ^@ http://purl.uniprot.org/uniprot/H8W8M0 ^@ Similarity ^@ Belongs to the WrbA family. http://togogenome.org/gene/1163748:MARHY_RS02755 ^@ http://purl.uniprot.org/uniprot/H8W465 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/1163748:MARHY_RS10305 ^@ http://purl.uniprot.org/uniprot/H8W742 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum|||Belongs to the bacterial flagellin family.|||Secreted http://togogenome.org/gene/1163748:MARHY_RS02940 ^@ http://purl.uniprot.org/uniprot/H8W4R5 ^@ Function|||Subunit ^@ Homotetramer.|||Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. http://togogenome.org/gene/1163748:MARHY_RS04930 ^@ http://purl.uniprot.org/uniprot/H8W872 ^@ Similarity ^@ Belongs to the peptidase S13 family. http://togogenome.org/gene/1163748:MARHY_RS11290 ^@ http://purl.uniprot.org/uniprot/H8W8L9 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/1163748:MARHY_RS00945 ^@ http://purl.uniprot.org/uniprot/H8WBQ2 ^@ Similarity ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Belongs to the peroxiredoxin family. Prx6 subfamily. http://togogenome.org/gene/1163748:MARHY_RS08495 ^@ http://purl.uniprot.org/uniprot/H8WEK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS03740 ^@ http://purl.uniprot.org/uniprot/H8W649 ^@ Similarity ^@ Belongs to the UPF0102 family. http://togogenome.org/gene/1163748:MARHY_RS12610 ^@ http://purl.uniprot.org/uniprot/H8WBC2 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily.|||Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. http://togogenome.org/gene/1163748:MARHY_RS06850 ^@ http://purl.uniprot.org/uniprot/H8WBS6 ^@ Function|||Similarity ^@ Belongs to the DUF177 domain family.|||Plays a role in synthesis, processing and/or stability of 23S rRNA. http://togogenome.org/gene/1163748:MARHY_RS15790 ^@ http://purl.uniprot.org/uniprot/H8W5Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS10380 ^@ http://purl.uniprot.org/uniprot/H8W758 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS06870 ^@ http://purl.uniprot.org/uniprot/H8WBT0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.|||Homotetramer. http://togogenome.org/gene/1163748:MARHY_RS15615 ^@ http://purl.uniprot.org/uniprot/H8W5F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS02910 ^@ http://purl.uniprot.org/uniprot/H8W499 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/1163748:MARHY_RS03855 ^@ http://purl.uniprot.org/uniprot/H8W672 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/1163748:MARHY_RS03490 ^@ http://purl.uniprot.org/uniprot/H8W5I8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/1163748:MARHY_RS15115 ^@ http://purl.uniprot.org/uniprot/H8W4N8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 2 lipoyl cofactors covalently.|||Forms a 24-polypeptide structural core with octahedral symmetry.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/1163748:MARHY_RS01900 ^@ http://purl.uniprot.org/uniprot/H8WDM4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Rho family.|||Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.|||Homohexamer. The homohexamer assembles into an open ring structure. http://togogenome.org/gene/1163748:MARHY_RS13865 ^@ http://purl.uniprot.org/uniprot/H8WDG5 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/1163748:MARHY_RS08810 ^@ http://purl.uniprot.org/uniprot/H8W4C3 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.|||Synthesizes alpha-1,4-glucan chains using ADP-glucose. http://togogenome.org/gene/1163748:MARHY_RS04555 ^@ http://purl.uniprot.org/uniprot/H8W7I2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Cytoplasm|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. http://togogenome.org/gene/1163748:MARHY_RS06310 ^@ http://purl.uniprot.org/uniprot/H8WAI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliR/MopE/SpaR family.|||Cell membrane|||Membrane|||Role in flagellar biosynthesis. http://togogenome.org/gene/1163748:MARHY_RS12570 ^@ http://purl.uniprot.org/uniprot/H8WBB4 ^@ Similarity ^@ Belongs to the DNA polymerase HolA subunit family. http://togogenome.org/gene/1163748:MARHY_RS06505 ^@ http://purl.uniprot.org/uniprot/H8WB45 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. RsmC family.|||Cytoplasm|||Monomer.|||Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle. http://togogenome.org/gene/1163748:MARHY_RS03420 ^@ http://purl.uniprot.org/uniprot/H8W5H5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/1163748:MARHY_RS02525 ^@ http://purl.uniprot.org/uniprot/H8WEG9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DksA family.|||Cytoplasm|||Interacts directly with the RNA polymerase.|||Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. http://togogenome.org/gene/1163748:MARHY_RS04210 ^@ http://purl.uniprot.org/uniprot/H8W6V3 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. IspE subfamily.|||Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. http://togogenome.org/gene/1163748:MARHY_RS05915 ^@ http://purl.uniprot.org/uniprot/H8W9Q0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1163748:MARHY_RS15865 ^@ http://purl.uniprot.org/uniprot/H8W616 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. PrmA family.|||Cytoplasm|||Methylates ribosomal protein L11. http://togogenome.org/gene/1163748:MARHY_RS02255 ^@ http://purl.uniprot.org/uniprot/H8WEA9 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/1163748:MARHY_RS00880 ^@ http://purl.uniprot.org/uniprot/H8WBN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS09300 ^@ http://purl.uniprot.org/uniprot/H8W555 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/1163748:MARHY_RS06330 ^@ http://purl.uniprot.org/uniprot/H8WAI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.|||Cell membrane|||Membrane|||Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin. http://togogenome.org/gene/1163748:MARHY_RS10280 ^@ http://purl.uniprot.org/uniprot/H8W738 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell membrane|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/1163748:MARHY_RS12995 ^@ http://purl.uniprot.org/uniprot/H8WC09 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RlmJ family.|||Monomer.|||Specifically methylates the adenine in position 2030 of 23S rRNA. http://togogenome.org/gene/1163748:MARHY_RS05050 ^@ http://purl.uniprot.org/uniprot/H8W8A0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/1163748:MARHY_RS12620 ^@ http://purl.uniprot.org/uniprot/H8WBC4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. Biotin synthase family.|||Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS03065 ^@ http://purl.uniprot.org/uniprot/H8W4U2 ^@ Subcellular Location Annotation ^@ Cell outer membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS15050 ^@ http://purl.uniprot.org/uniprot/H8W4M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS11485 ^@ http://purl.uniprot.org/uniprot/H8W964 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/1163748:MARHY_RS01770 ^@ http://purl.uniprot.org/uniprot/H8WD38 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.|||Binds 2 manganese ions per subunit.|||Splits dipeptides with a prolyl residue in the C-terminal position. http://togogenome.org/gene/1163748:MARHY_RS15205 ^@ http://purl.uniprot.org/uniprot/H8W4Q6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/1163748:MARHY_RS14265 ^@ http://purl.uniprot.org/uniprot/H8WE62 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS16825 ^@ http://purl.uniprot.org/uniprot/H8W7Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS17355 ^@ http://purl.uniprot.org/uniprot/H8W8R5 ^@ Similarity ^@ Belongs to the hyi family. http://togogenome.org/gene/1163748:MARHY_RS10780 ^@ http://purl.uniprot.org/uniprot/H8W7V3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS00865 ^@ http://purl.uniprot.org/uniprot/H8WBN6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS16665 ^@ http://purl.uniprot.org/uniprot/H8W7F0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.|||Cell inner membrane http://togogenome.org/gene/1163748:MARHY_RS00460 ^@ http://purl.uniprot.org/uniprot/H8WAZ2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/1163748:MARHY_RS03050 ^@ http://purl.uniprot.org/uniprot/H8W4T8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS15065 ^@ http://purl.uniprot.org/uniprot/H8W4M8 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/1163748:MARHY_RS01945 ^@ http://purl.uniprot.org/uniprot/H8WDN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Cytoplasm|||In the N-terminal section; belongs to the lyase 1 family. Argininosuccinate lyase subfamily. http://togogenome.org/gene/1163748:MARHY_RS02845 ^@ http://purl.uniprot.org/uniprot/H8W484 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1163748:MARHY_RS18250 ^@ http://purl.uniprot.org/uniprot/H8WA70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS04055 ^@ http://purl.uniprot.org/uniprot/H8W6B3 ^@ Function|||Similarity ^@ Belongs to the MurCDEF family. Mpl subfamily.|||Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate. http://togogenome.org/gene/1163748:MARHY_RS18330 ^@ http://purl.uniprot.org/uniprot/H8WAT9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.|||Cell membrane|||Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.|||Membrane|||Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. http://togogenome.org/gene/1163748:MARHY_RS12785 ^@ http://purl.uniprot.org/uniprot/H8WBF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS10015 ^@ http://purl.uniprot.org/uniprot/H8W6H4 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS14220 ^@ http://purl.uniprot.org/uniprot/H8WE53 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/1163748:MARHY_RS12895 ^@ http://purl.uniprot.org/uniprot/H8WBI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0126 family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS11120 ^@ http://purl.uniprot.org/uniprot/H8W8I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS15335 ^@ http://purl.uniprot.org/uniprot/H8W593 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/1163748:MARHY_RS12670 ^@ http://purl.uniprot.org/uniprot/H8WBD4 ^@ Function|||Similarity ^@ Belongs to the band 7/mec-2 family. HflC subfamily.|||HflC and HflK could regulate a protease. http://togogenome.org/gene/1163748:MARHY_RS10225 ^@ http://purl.uniprot.org/uniprot/H8W727 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspG family.|||Binds 1 [4Fe-4S] cluster.|||Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. http://togogenome.org/gene/1163748:MARHY_RS08390 ^@ http://purl.uniprot.org/uniprot/H8WEI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS04845 ^@ http://purl.uniprot.org/uniprot/H8W7P5 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS10625 ^@ http://purl.uniprot.org/uniprot/H8W7S1 ^@ Similarity ^@ Belongs to the peptidase M18 family. http://togogenome.org/gene/1163748:MARHY_RS02890 ^@ http://purl.uniprot.org/uniprot/H8W494 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1163748:MARHY_RS03770 ^@ http://purl.uniprot.org/uniprot/H8W655 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transpeptidase family. FtsI subfamily.|||Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.|||Cell inner membrane http://togogenome.org/gene/1163748:MARHY_RS11815 ^@ http://purl.uniprot.org/uniprot/H8W9T9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.|||Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.|||Cytoplasm|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS02935 ^@ http://purl.uniprot.org/uniprot/H8W4R4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS07275 ^@ http://purl.uniprot.org/uniprot/H8WCH3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CcoP / FixP family.|||Binds 2 heme C groups per subunit.|||C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.|||Cell inner membrane|||Component of the cbb3-type cytochrome c oxidase. http://togogenome.org/gene/1163748:MARHY_RS04705 ^@ http://purl.uniprot.org/uniprot/H8W7L6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS04195 ^@ http://purl.uniprot.org/uniprot/H8W6V1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/1163748:MARHY_RS11235 ^@ http://purl.uniprot.org/uniprot/H8W8K8 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruD family.|||Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. http://togogenome.org/gene/1163748:MARHY_RS07620 ^@ http://purl.uniprot.org/uniprot/H8WD56 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvA family.|||Cytoplasm|||Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.|||Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/1163748:MARHY_RS17920 ^@ http://purl.uniprot.org/uniprot/H8W9Z9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer.|||Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein. http://togogenome.org/gene/1163748:MARHY_RS14780 ^@ http://purl.uniprot.org/uniprot/H8WEX4 ^@ Similarity ^@ Belongs to the SufE family. http://togogenome.org/gene/1163748:MARHY_RS15400 ^@ http://purl.uniprot.org/uniprot/H8W5B2 ^@ Similarity ^@ Belongs to the MQO family. http://togogenome.org/gene/1163748:MARHY_RS03445 ^@ http://purl.uniprot.org/uniprot/H8W5I0 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the thiamine-monophosphate kinase family.|||Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. http://togogenome.org/gene/1163748:MARHY_RS04725 ^@ http://purl.uniprot.org/uniprot/H8W7M0 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/1163748:MARHY_RS18235 ^@ http://purl.uniprot.org/uniprot/H8WA67 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/1163748:MARHY_RS11735 ^@ http://purl.uniprot.org/uniprot/H8W9S3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thioester dehydratase family. FabZ subfamily.|||Cytoplasm|||Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. http://togogenome.org/gene/1163748:MARHY_RS00255 ^@ http://purl.uniprot.org/uniprot/H8WAU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS03760 ^@ http://purl.uniprot.org/uniprot/H8W653 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmH family.|||Cytoplasm|||Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. http://togogenome.org/gene/1163748:MARHY_RS12325 ^@ http://purl.uniprot.org/uniprot/H8WAP6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. http://togogenome.org/gene/1163748:MARHY_RS07045 ^@ http://purl.uniprot.org/uniprot/H8WBW3 ^@ Caution|||Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS02135 ^@ http://purl.uniprot.org/uniprot/H8WDS3 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS16890 ^@ http://purl.uniprot.org/uniprot/H8W808 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS15255 ^@ http://purl.uniprot.org/uniprot/H8W577 ^@ Function|||Similarity ^@ Belongs to the DHPS family.|||Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives. http://togogenome.org/gene/1163748:MARHY_RS16610 ^@ http://purl.uniprot.org/uniprot/H8W7D9 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/1163748:MARHY_RS02310 ^@ http://purl.uniprot.org/uniprot/H8WEC0 ^@ Disruption Phenotype|||Function|||Induction|||Subcellular Location Annotation|||Subunit ^@ Cell inner membrane|||Expression increases during biofilm formation on n-hexadecane. Forms an operon with aupA.|||Interacts with the outer membrane protein AupA.|||Mutants show a lower rate of biofilm formation on solid paraffin and on the liquid alkane n-hexadecane, while growth on nonalkane substrates was not affected. Planktonic growth on water-soluble substrates is not affected. Mutants are impaired in the assimilation of n-hexadecane solubilized in surfactant micelles.|||Required for growth on alkanes. Probably involved in the uptake of micelle-solubilized alkanes. May facilitate the transfer of alkanes from the outer membrane to the inner membrane. http://togogenome.org/gene/1163748:MARHY_RS16415 ^@ http://purl.uniprot.org/uniprot/H8W797 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein ModA family. http://togogenome.org/gene/1163748:MARHY_RS05080 ^@ http://purl.uniprot.org/uniprot/H8W8A6 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/1163748:MARHY_RS12600 ^@ http://purl.uniprot.org/uniprot/H8WBC0 ^@ Similarity ^@ Belongs to the flagella basal body rod proteins family. http://togogenome.org/gene/1163748:MARHY_RS09215 ^@ http://purl.uniprot.org/uniprot/H8W535 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer.|||Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0). http://togogenome.org/gene/1163748:MARHY_RS18180 ^@ http://purl.uniprot.org/uniprot/H8WA56 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. http://togogenome.org/gene/1163748:MARHY_RS07600 ^@ http://purl.uniprot.org/uniprot/H8WD52 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS06710 ^@ http://purl.uniprot.org/uniprot/H8WB86 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/1163748:MARHY_RS07700 ^@ http://purl.uniprot.org/uniprot/H8WD70 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/1163748:MARHY_RS09730 ^@ http://purl.uniprot.org/uniprot/H8W5V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.|||Cell outer membrane http://togogenome.org/gene/1163748:MARHY_RS08325 ^@ http://purl.uniprot.org/uniprot/H8WE12 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS13580 ^@ http://purl.uniprot.org/uniprot/H8WCU5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS02795 ^@ http://purl.uniprot.org/uniprot/H8W474 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1163748:MARHY_RS17745 ^@ http://purl.uniprot.org/uniprot/H8W9F5 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the peroxiredoxin family. Tpx subfamily.|||Homodimer.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/1163748:MARHY_RS11920 ^@ http://purl.uniprot.org/uniprot/H8W9W0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS13180 ^@ http://purl.uniprot.org/uniprot/H8WC47 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/1163748:MARHY_RS14380 ^@ http://purl.uniprot.org/uniprot/H8WE85 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Monomer and homodimer. http://togogenome.org/gene/1163748:MARHY_RS02165 ^@ http://purl.uniprot.org/uniprot/H8WDS9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. MetX family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. http://togogenome.org/gene/1163748:MARHY_RS03225 ^@ http://purl.uniprot.org/uniprot/H8W4X4 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/1163748:MARHY_RS13630 ^@ http://purl.uniprot.org/uniprot/H8WCV8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS06135 ^@ http://purl.uniprot.org/uniprot/H8WAE7 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/1163748:MARHY_RS09165 ^@ http://purl.uniprot.org/uniprot/H8W522 ^@ Similarity ^@ Belongs to the phosphate/phosphite/phosphonate binding protein family. http://togogenome.org/gene/1163748:MARHY_RS12540 ^@ http://purl.uniprot.org/uniprot/H8WBA7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endoribonuclease YbeY family.|||Binds 1 zinc ion.|||Cytoplasm|||Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. http://togogenome.org/gene/1163748:MARHY_RS12020 ^@ http://purl.uniprot.org/uniprot/H8W9Y1 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. http://togogenome.org/gene/1163748:MARHY_RS03620 ^@ http://purl.uniprot.org/uniprot/H8W5L6 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/1163748:MARHY_RS16065 ^@ http://purl.uniprot.org/uniprot/H8W6L8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter small permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/1163748:MARHY_RS02495 ^@ http://purl.uniprot.org/uniprot/H8WEG3 ^@ Function|||Similarity ^@ Belongs to the HPPK family.|||Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway. http://togogenome.org/gene/1163748:MARHY_RS10240 ^@ http://purl.uniprot.org/uniprot/H8W730 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RlmN family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.|||Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity. http://togogenome.org/gene/1163748:MARHY_RS15310 ^@ http://purl.uniprot.org/uniprot/H8W588 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Fur family.|||Binds 1 Mn(2+) or Fe(2+) ion per subunit.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS06620 ^@ http://purl.uniprot.org/uniprot/H8WB68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transaldolase family. Type 1 subfamily.|||Cytoplasm|||Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. http://togogenome.org/gene/1163748:MARHY_RS10995 ^@ http://purl.uniprot.org/uniprot/H8W8G1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OadG family.|||Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.|||Cell membrane|||Heterotrimer of an alpha, a beta and a gamma subunit.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS11770 ^@ http://purl.uniprot.org/uniprot/H8W9T0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS15825 ^@ http://purl.uniprot.org/uniprot/H8W606 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS12005 ^@ http://purl.uniprot.org/uniprot/H8W9X8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.|||Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS05950 ^@ http://purl.uniprot.org/uniprot/H8W9Q8 ^@ Function|||Similarity ^@ In the C-terminal section; belongs to the aldehyde dehydrogenase family.|||In the N-terminal section; belongs to the proline dehydrogenase family.|||Oxidizes proline to glutamate for use as a carbon and nitrogen source. http://togogenome.org/gene/1163748:MARHY_RS01595 ^@ http://purl.uniprot.org/uniprot/H8WD04 ^@ Similarity ^@ Belongs to the AlaDH/PNT family. http://togogenome.org/gene/1163748:MARHY_RS15520 ^@ http://purl.uniprot.org/uniprot/H8W5D7 ^@ Function|||Similarity ^@ Belongs to the PqqB family.|||May be involved in the transport of PQQ or its precursor to the periplasm. http://togogenome.org/gene/1163748:MARHY_RS13125 ^@ http://purl.uniprot.org/uniprot/H8WC36 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS03700 ^@ http://purl.uniprot.org/uniprot/H8W5M9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/1163748:MARHY_RS02825 ^@ http://purl.uniprot.org/uniprot/H8W480 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/1163748:MARHY_RS06875 ^@ http://purl.uniprot.org/uniprot/H8WBT1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS02475 ^@ http://purl.uniprot.org/uniprot/H8WEF9 ^@ Function|||Similarity ^@ Belongs to the HPPK family.|||Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway. http://togogenome.org/gene/1163748:MARHY_RS10250 ^@ http://purl.uniprot.org/uniprot/H8W732 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1163748:MARHY_RS03800 ^@ http://purl.uniprot.org/uniprot/H8W661 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family. MurG subfamily.|||Cell membrane|||Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II). http://togogenome.org/gene/1163748:MARHY_RS09795 ^@ http://purl.uniprot.org/uniprot/H8W6C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS07375 ^@ http://purl.uniprot.org/uniprot/H8WCJ4 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS02275 ^@ http://purl.uniprot.org/uniprot/H8WEB3 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/1163748:MARHY_RS13635 ^@ http://purl.uniprot.org/uniprot/H8WCV9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1163748:MARHY_RS13960 ^@ http://purl.uniprot.org/uniprot/H8WDI7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.|||Cytoplasm|||Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.|||Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. http://togogenome.org/gene/1163748:MARHY_RS12485 ^@ http://purl.uniprot.org/uniprot/H8WAS7 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS07020 ^@ http://purl.uniprot.org/uniprot/H8WBV6 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/1163748:MARHY_RS06715 ^@ http://purl.uniprot.org/uniprot/H8WB87 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the selenophosphate synthase 1 family. Class I subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Homodimer.|||Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/1163748:MARHY_RS02095 ^@ http://purl.uniprot.org/uniprot/H8WDR4 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/1163748:MARHY_RS09505 ^@ http://purl.uniprot.org/uniprot/H8W5Q9 ^@ Similarity ^@ In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1163748:MARHY_RS05670 ^@ http://purl.uniprot.org/uniprot/H8W9J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MgtC/SapB family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS12330 ^@ http://purl.uniprot.org/uniprot/H8WAP7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATP phosphoribosyltransferase family. Short subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Heteromultimer composed of HisG and HisZ subunits.|||Lacks the C-terminal regulatory region which is replaced by HisZ. http://togogenome.org/gene/1163748:MARHY_RS12615 ^@ http://purl.uniprot.org/uniprot/H8WBC3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.|||Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS09670 ^@ http://purl.uniprot.org/uniprot/H8W5U3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GSP I family.|||Cell inner membrane|||Cleaved by prepilin peptidase.|||Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.|||Membrane|||Type II secretion is composed of four main components: the outer membrane complex, the inner membrane complex, the cytoplasmic secretion ATPase and the periplasm-spanning pseudopilus. http://togogenome.org/gene/1163748:MARHY_RS01895 ^@ http://purl.uniprot.org/uniprot/H8WDM3 ^@ Function|||Similarity ^@ Belongs to the MoaB/Mog family.|||May be involved in the biosynthesis of molybdopterin. http://togogenome.org/gene/1163748:MARHY_RS15175 ^@ http://purl.uniprot.org/uniprot/H8W4Q0 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/1163748:MARHY_RS17410 ^@ http://purl.uniprot.org/uniprot/H8W8S6 ^@ Similarity ^@ Belongs to the HSP15 family. http://togogenome.org/gene/1163748:MARHY_RS06885 ^@ http://purl.uniprot.org/uniprot/H8WBT3 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/1163748:MARHY_RS06370 ^@ http://purl.uniprot.org/uniprot/H8WAJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS04735 ^@ http://purl.uniprot.org/uniprot/H8W7M2 ^@ Function|||Similarity ^@ Belongs to the relA/spoT family.|||In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. http://togogenome.org/gene/1163748:MARHY_RS09255 ^@ http://purl.uniprot.org/uniprot/H8W544 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/1163748:MARHY_RS13985 ^@ http://purl.uniprot.org/uniprot/H8WDJ3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the urease gamma subunit family.|||Cytoplasm|||Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. http://togogenome.org/gene/1163748:MARHY_RS17100 ^@ http://purl.uniprot.org/uniprot/H8W852 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0410 family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS13690 ^@ http://purl.uniprot.org/uniprot/H8WDC9 ^@ Similarity ^@ Belongs to the peptidase C56 family. http://togogenome.org/gene/1163748:MARHY_RS04830 ^@ http://purl.uniprot.org/uniprot/H8W7P1 ^@ Function|||PTM|||Similarity ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.|||Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. http://togogenome.org/gene/1163748:MARHY_RS03295 ^@ http://purl.uniprot.org/uniprot/H8W4Y8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS16830 ^@ http://purl.uniprot.org/uniprot/H8W7Z6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell inner membrane|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/1163748:MARHY_RS12070 ^@ http://purl.uniprot.org/uniprot/H8W9Z2 ^@ Similarity ^@ Belongs to the bacterial sugar transferase family. http://togogenome.org/gene/1163748:MARHY_RS01260 ^@ http://purl.uniprot.org/uniprot/H8WCC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MotA family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS17435 ^@ http://purl.uniprot.org/uniprot/H8W8T2 ^@ Similarity|||Subunit ^@ Belongs to the bacterial histone-like protein family.|||Heterodimer of an alpha and a beta chain. http://togogenome.org/gene/1163748:MARHY_RS16110 ^@ http://purl.uniprot.org/uniprot/H8W6M7 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/1163748:MARHY_RS17420 ^@ http://purl.uniprot.org/uniprot/H8W8S8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.|||Binds 1 Mn(2+) ion per subunit.|||Cytoplasm|||Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS17000 ^@ http://purl.uniprot.org/uniprot/H8W831 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS04090 ^@ http://purl.uniprot.org/uniprot/H8W6C0 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with bS18 to 16S ribosomal RNA. http://togogenome.org/gene/1163748:MARHY_RS15610 ^@ http://purl.uniprot.org/uniprot/H8W5F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS01430 ^@ http://purl.uniprot.org/uniprot/H8WCX1 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS01505 ^@ http://purl.uniprot.org/uniprot/H8WCY6 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/1163748:MARHY_RS05590 ^@ http://purl.uniprot.org/uniprot/H8W924 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS12905 ^@ http://purl.uniprot.org/uniprot/H8WBI2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS13725 ^@ http://purl.uniprot.org/uniprot/H8WDD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MgtC/SapB family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS04135 ^@ http://purl.uniprot.org/uniprot/H8W6T8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.|||Cytoplasm|||Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity. http://togogenome.org/gene/1163748:MARHY_RS04115 ^@ http://purl.uniprot.org/uniprot/H8W6T4 ^@ Function|||Similarity ^@ Belongs to the alanine racemase family.|||Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. http://togogenome.org/gene/1163748:MARHY_RS15480 ^@ http://purl.uniprot.org/uniprot/H8W5C9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS06335 ^@ http://purl.uniprot.org/uniprot/H8WAI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family.|||Cell membrane|||Membrane|||Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum. http://togogenome.org/gene/1163748:MARHY_RS00170 ^@ http://purl.uniprot.org/uniprot/H8WAB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aerobic coproporphyrinogen-III oxidase family.|||Cytoplasm|||Homodimer.|||Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. http://togogenome.org/gene/1163748:MARHY_RS05275 ^@ http://purl.uniprot.org/uniprot/H8W8V6 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/1163748:MARHY_RS15745 ^@ http://purl.uniprot.org/uniprot/H8W5Y9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/1163748:MARHY_RS03710 ^@ http://purl.uniprot.org/uniprot/H8W5N1 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.|||Membrane|||The Rieske protein is a high potential 2Fe-2S protein.|||The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein. http://togogenome.org/gene/1163748:MARHY_RS17825 ^@ http://purl.uniprot.org/uniprot/H8W9H1 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/1163748:MARHY_RS08485 ^@ http://purl.uniprot.org/uniprot/H8WEK7 ^@ Similarity ^@ Belongs to the DsrF/TusC family. http://togogenome.org/gene/1163748:MARHY_RS09790 ^@ http://purl.uniprot.org/uniprot/H8W6C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 1 family.|||Periplasm http://togogenome.org/gene/1163748:MARHY_RS03305 ^@ http://purl.uniprot.org/uniprot/H8W4Z0 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||Allosterically activated by HslU binding.|||Belongs to the peptidase T1B family. HslV subfamily.|||Cytoplasm|||Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. http://togogenome.org/gene/1163748:MARHY_RS09150 ^@ http://purl.uniprot.org/uniprot/H8W519 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS04550 ^@ http://purl.uniprot.org/uniprot/H8W7I1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS05775 ^@ http://purl.uniprot.org/uniprot/H8W9L8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS13455 ^@ http://purl.uniprot.org/uniprot/H8WCS0 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/1163748:MARHY_RS09640 ^@ http://purl.uniprot.org/uniprot/H8W5T7 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/1163748:MARHY_RS01350 ^@ http://purl.uniprot.org/uniprot/H8WCE3 ^@ Similarity ^@ Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family. http://togogenome.org/gene/1163748:MARHY_RS14735 ^@ http://purl.uniprot.org/uniprot/H8WEW5 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/1163748:MARHY_RS02150 ^@ http://purl.uniprot.org/uniprot/H8WDS6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/1163748:MARHY_RS06325 ^@ http://purl.uniprot.org/uniprot/H8WAI6 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/1163748:MARHY_RS14215 ^@ http://purl.uniprot.org/uniprot/H8WE52 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/1163748:MARHY_RS02145 ^@ http://purl.uniprot.org/uniprot/H8WDS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||Cytoplasm|||Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/1163748:MARHY_RS15045 ^@ http://purl.uniprot.org/uniprot/H8W4M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS08590 ^@ http://purl.uniprot.org/uniprot/H8WEM8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS14330 ^@ http://purl.uniprot.org/uniprot/H8WE75 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS04185 ^@ http://purl.uniprot.org/uniprot/H8W6U9 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/1163748:MARHY_RS16675 ^@ http://purl.uniprot.org/uniprot/H8W7F2 ^@ Function ^@ Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals. http://togogenome.org/gene/1163748:MARHY_RS09270 ^@ http://purl.uniprot.org/uniprot/H8W547 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.|||Belongs to the azoreductase type 1 family.|||Binds 1 FMN per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones. http://togogenome.org/gene/1163748:MARHY_RS13375 ^@ http://purl.uniprot.org/uniprot/H8WCQ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS09565 ^@ http://purl.uniprot.org/uniprot/H8W5S2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/1163748:MARHY_RS02590 ^@ http://purl.uniprot.org/uniprot/H8W438 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the thiamine-phosphate synthase family.|||Binds 1 Mg(2+) ion per subunit.|||Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS17085 ^@ http://purl.uniprot.org/uniprot/H8W849 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS00500 ^@ http://purl.uniprot.org/uniprot/H8WB00 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS12720 ^@ http://purl.uniprot.org/uniprot/H8WBE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-to-5' exoribonuclease specific for small oligoribonucleotides.|||Belongs to the oligoribonuclease family.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS02905 ^@ http://purl.uniprot.org/uniprot/H8W498 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/1163748:MARHY_RS07480 ^@ http://purl.uniprot.org/uniprot/H8WCL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS16370 ^@ http://purl.uniprot.org/uniprot/H8W6T1 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/1163748:MARHY_RS10310 ^@ http://purl.uniprot.org/uniprot/H8W743 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum|||Belongs to the flagella basal body rod proteins family.|||Secreted http://togogenome.org/gene/1163748:MARHY_RS01175 ^@ http://purl.uniprot.org/uniprot/H8WCA7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS08820 ^@ http://purl.uniprot.org/uniprot/H8W4C5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.|||Homotetramer.|||Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. http://togogenome.org/gene/1163748:MARHY_RS15885 ^@ http://purl.uniprot.org/uniprot/H8W620 ^@ Domain|||Similarity ^@ Belongs to the PurH family.|||The IMP cyclohydrolase activity resides in the N-terminal region. http://togogenome.org/gene/1163748:MARHY_RS04290 ^@ http://purl.uniprot.org/uniprot/H8W6W9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS13235 ^@ http://purl.uniprot.org/uniprot/H8WC59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AzlC family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS06375 ^@ http://purl.uniprot.org/uniprot/H8WAJ6 ^@ Similarity ^@ Belongs to the MotB family. http://togogenome.org/gene/1163748:MARHY_RS10315 ^@ http://purl.uniprot.org/uniprot/H8W744 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space.|||In the C-terminal section; belongs to the glycosyl hydrolase 73 family.|||In the N-terminal section; belongs to the FlgJ family.|||Periplasm http://togogenome.org/gene/1163748:MARHY_RS07795 ^@ http://purl.uniprot.org/uniprot/H8WD89 ^@ Similarity ^@ Belongs to the UDPGP type 2 family. http://togogenome.org/gene/1163748:MARHY_RS03625 ^@ http://purl.uniprot.org/uniprot/H8W5L7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/1163748:MARHY_RS11245 ^@ http://purl.uniprot.org/uniprot/H8W8L0 ^@ Function|||Similarity ^@ Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). http://togogenome.org/gene/1163748:MARHY_RS03845 ^@ http://purl.uniprot.org/uniprot/H8W670 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/1163748:MARHY_RS06540 ^@ http://purl.uniprot.org/uniprot/H8WB52 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.|||Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS03705 ^@ http://purl.uniprot.org/uniprot/H8W5N0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/1163748:MARHY_RS12605 ^@ http://purl.uniprot.org/uniprot/H8WBC1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dethiobiotin synthetase family.|||Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS03300 ^@ http://purl.uniprot.org/uniprot/H8W4Y9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.|||Belongs to the ClpX chaperone family. HslU subfamily.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS05535 ^@ http://purl.uniprot.org/uniprot/H8W913 ^@ Similarity ^@ Belongs to the HMG-CoA lyase family. http://togogenome.org/gene/1163748:MARHY_RS10345 ^@ http://purl.uniprot.org/uniprot/H8W751 ^@ Function|||Similarity ^@ Belongs to the FlgD family.|||Required for flagellar hook formation. May act as a scaffolding protein. http://togogenome.org/gene/1163748:MARHY_RS06075 ^@ http://purl.uniprot.org/uniprot/H8WAD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS06845 ^@ http://purl.uniprot.org/uniprot/H8WBS5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family. YceF subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/1163748:MARHY_RS00025 ^@ http://purl.uniprot.org/uniprot/H8WA84 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/1163748:MARHY_RS16765 ^@ http://purl.uniprot.org/uniprot/H8W7Y3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SNF2/RAD54 helicase family. RapA subfamily.|||Interacts with the RNAP. Has a higher affinity for the core RNAP than for the holoenzyme. Its ATPase activity is stimulated by binding to RNAP.|||Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair. http://togogenome.org/gene/1163748:MARHY_RS10795 ^@ http://purl.uniprot.org/uniprot/H8W7V6 ^@ Caution|||Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Belongs to the MsrB Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS05790 ^@ http://purl.uniprot.org/uniprot/H8W9M1 ^@ Similarity ^@ Belongs to the peptidase S16 family. http://togogenome.org/gene/1163748:MARHY_RS15040 ^@ http://purl.uniprot.org/uniprot/H8W4M3 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 3 family. http://togogenome.org/gene/1163748:MARHY_RS08310 ^@ http://purl.uniprot.org/uniprot/H8WE09 ^@ Function|||Similarity ^@ Belongs to the folylpolyglutamate synthase family.|||Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. http://togogenome.org/gene/1163748:MARHY_RS07625 ^@ http://purl.uniprot.org/uniprot/H8WD57 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvB family.|||Cytoplasm|||Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.|||Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA. http://togogenome.org/gene/1163748:MARHY_RS09805 ^@ http://purl.uniprot.org/uniprot/H8W6D0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MlaE permease family.|||Cell inner membrane|||Membrane|||Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.|||The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD). http://togogenome.org/gene/1163748:MARHY_RS00110 ^@ http://purl.uniprot.org/uniprot/H8WAA1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Cell outer membrane|||Homodimer.|||Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids. http://togogenome.org/gene/1163748:MARHY_RS13990 ^@ http://purl.uniprot.org/uniprot/H8WDJ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UreD family.|||Cytoplasm|||Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.|||UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. http://togogenome.org/gene/1163748:MARHY_RS14855 ^@ http://purl.uniprot.org/uniprot/H8W4I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS04140 ^@ http://purl.uniprot.org/uniprot/H8W6U0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CpxP/Spy family.|||Periplasm http://togogenome.org/gene/1163748:MARHY_RS01015 ^@ http://purl.uniprot.org/uniprot/H8WC74 ^@ Function|||Similarity ^@ Belongs to the CobU/CobP family.|||Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. http://togogenome.org/gene/1163748:MARHY_RS15740 ^@ http://purl.uniprot.org/uniprot/H8W5Y8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.|||The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. http://togogenome.org/gene/1163748:MARHY_RS17935 ^@ http://purl.uniprot.org/uniprot/H8WA03 ^@ Function|||Similarity ^@ Belongs to the GMC oxidoreductase family.|||Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. http://togogenome.org/gene/1163748:MARHY_RS04060 ^@ http://purl.uniprot.org/uniprot/H8W6B4 ^@ Caution|||Function|||Similarity ^@ Belongs to the UbiX/PAD1 family.|||Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS12130 ^@ http://purl.uniprot.org/uniprot/H8WAK7 ^@ Similarity ^@ Belongs to the polysaccharide synthase family. http://togogenome.org/gene/1163748:MARHY_RS17660 ^@ http://purl.uniprot.org/uniprot/H8W9D6 ^@ Function|||Similarity ^@ Belongs to the vsr family.|||May nick specific sequences that contain T:G mispairs resulting from m5C-deamination. http://togogenome.org/gene/1163748:MARHY_RS05825 ^@ http://purl.uniprot.org/uniprot/H8W9M8 ^@ Similarity ^@ In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family. http://togogenome.org/gene/1163748:MARHY_RS04940 ^@ http://purl.uniprot.org/uniprot/H8W875 ^@ Similarity ^@ Belongs to the Gfa family. http://togogenome.org/gene/1163748:MARHY_RS03815 ^@ http://purl.uniprot.org/uniprot/H8W664 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsQ/DivIB family. FtsQ subfamily.|||Cell inner membrane|||Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.|||Part of a complex composed of FtsB, FtsL and FtsQ. http://togogenome.org/gene/1163748:MARHY_RS05585 ^@ http://purl.uniprot.org/uniprot/H8W923 ^@ Similarity ^@ Belongs to the CmpA/NrtA family. http://togogenome.org/gene/1163748:MARHY_RS10705 ^@ http://purl.uniprot.org/uniprot/H8W7T8 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS1 family.|||Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. http://togogenome.org/gene/1163748:MARHY_RS04390 ^@ http://purl.uniprot.org/uniprot/H8W6Y9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DNA polymerase type-Y family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Monomer.|||Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. http://togogenome.org/gene/1163748:MARHY_RS12530 ^@ http://purl.uniprot.org/uniprot/H8WBA5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methylthiotransferase family. MiaB subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS04980 ^@ http://purl.uniprot.org/uniprot/H8W883 ^@ Similarity ^@ Belongs to the UPF0178 family. http://togogenome.org/gene/1163748:MARHY_RS08335 ^@ http://purl.uniprot.org/uniprot/H8WE14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FtsK/SpoIIIE/SftA family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS06795 ^@ http://purl.uniprot.org/uniprot/H8WBR4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class II aldolase/RraA-like family.|||Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.|||Homotrimer. http://togogenome.org/gene/1163748:MARHY_RS05545 ^@ http://purl.uniprot.org/uniprot/H8W915 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/1163748:MARHY_RS07830 ^@ http://purl.uniprot.org/uniprot/H8WD97 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/1163748:MARHY_RS07590 ^@ http://purl.uniprot.org/uniprot/H8WD50 ^@ Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS09510 ^@ http://purl.uniprot.org/uniprot/H8W5R0 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/1163748:MARHY_RS05215 ^@ http://purl.uniprot.org/uniprot/H8W8D3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein PotD/PotF family.|||Periplasm|||Required for the activity of the bacterial periplasmic transport system of putrescine. http://togogenome.org/gene/1163748:MARHY_RS03235 ^@ http://purl.uniprot.org/uniprot/H8W4X6 ^@ Function|||Similarity ^@ Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process.|||Belongs to the Nudix hydrolase family. NudF subfamily. http://togogenome.org/gene/1163748:MARHY_RS11210 ^@ http://purl.uniprot.org/uniprot/H8W8K3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoS subfamily.|||Cytoplasm|||Interacts with the RNA polymerase core enzyme.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. http://togogenome.org/gene/1163748:MARHY_RS13245 ^@ http://purl.uniprot.org/uniprot/H8WC61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS06665 ^@ http://purl.uniprot.org/uniprot/H8WB77 ^@ Function|||Similarity ^@ Belongs to the methylglyoxal synthase family.|||Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. http://togogenome.org/gene/1163748:MARHY_RS09230 ^@ http://purl.uniprot.org/uniprot/H8W538 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MerT family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS01915 ^@ http://purl.uniprot.org/uniprot/H8WDM7 ^@ Function|||Subcellular Location Annotation ^@ Cell inner membrane|||Involved in a late step of protoheme IX synthesis.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS07340 ^@ http://purl.uniprot.org/uniprot/H8WCI7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS10560 ^@ http://purl.uniprot.org/uniprot/H8W7Q8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 90 family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Molecular chaperone. Has ATPase activity. http://togogenome.org/gene/1163748:MARHY_RS01870 ^@ http://purl.uniprot.org/uniprot/H8WDL8 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/1163748:MARHY_RS12320 ^@ http://purl.uniprot.org/uniprot/H8WAP5 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS06095 ^@ http://purl.uniprot.org/uniprot/H8WAE2 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/1163748:MARHY_RS02750 ^@ http://purl.uniprot.org/uniprot/H8W464 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/1163748:MARHY_RS15160 ^@ http://purl.uniprot.org/uniprot/H8W4P7 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS00225 ^@ http://purl.uniprot.org/uniprot/H8WAC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS15215 ^@ http://purl.uniprot.org/uniprot/H8W4Q8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/1163748:MARHY_RS17735 ^@ http://purl.uniprot.org/uniprot/H8W9F3 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS15735 ^@ http://purl.uniprot.org/uniprot/H8W5Y7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatB family.|||Cell membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.|||The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. http://togogenome.org/gene/1163748:MARHY_RS01115 ^@ http://purl.uniprot.org/uniprot/H8WC95 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS13240 ^@ http://purl.uniprot.org/uniprot/H8WC60 ^@ Function|||Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. http://togogenome.org/gene/1163748:MARHY_RS03105 ^@ http://purl.uniprot.org/uniprot/H8W4V0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS17495 ^@ http://purl.uniprot.org/uniprot/H8W8U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS02780 ^@ http://purl.uniprot.org/uniprot/H8W470 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/1163748:MARHY_RS05650 ^@ http://purl.uniprot.org/uniprot/H8W9J3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS06340 ^@ http://purl.uniprot.org/uniprot/H8WAI9 ^@ Similarity ^@ Belongs to the ParA family. MinD subfamily. http://togogenome.org/gene/1163748:MARHY_RS15240 ^@ http://purl.uniprot.org/uniprot/H8W4R2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS09980 ^@ http://purl.uniprot.org/uniprot/H8W6G7 ^@ Function|||Similarity ^@ Belongs to the FlgM family.|||Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA. http://togogenome.org/gene/1163748:MARHY_RS05295 ^@ http://purl.uniprot.org/uniprot/H8W8W0 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS18265 ^@ http://purl.uniprot.org/uniprot/H8WA73 ^@ Function|||Similarity ^@ Belongs to the ParB family.|||Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication. http://togogenome.org/gene/1163748:MARHY_RS07580 ^@ http://purl.uniprot.org/uniprot/H8WD48 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS14370 ^@ http://purl.uniprot.org/uniprot/H8WE83 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS06905 ^@ http://purl.uniprot.org/uniprot/H8WBT7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Catalyzes the sodium-dependent uptake of extracellular L-proline.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS17415 ^@ http://purl.uniprot.org/uniprot/H8W8S7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HSP33 family.|||Cytoplasm|||Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.|||Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive. http://togogenome.org/gene/1163748:MARHY_RS11820 ^@ http://purl.uniprot.org/uniprot/H8W9U0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M20A family. DapE subfamily.|||Binds 2 Zn(2+) or Co(2+) ions per subunit.|||Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS09105 ^@ http://purl.uniprot.org/uniprot/H8W509 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS18135 ^@ http://purl.uniprot.org/uniprot/H8WA46 ^@ Function|||Similarity ^@ Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates.|||Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.|||Catalyzes the hydrolysis of short-chain aliphatic amides to their corresponding organic acids with release of ammonia. http://togogenome.org/gene/1163748:MARHY_RS07935 ^@ http://purl.uniprot.org/uniprot/H8WDC0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS14625 ^@ http://purl.uniprot.org/uniprot/H8WEU3 ^@ Similarity|||Subunit ^@ Belongs to the Ahb/Nir family.|||Probably forms a complex composed of NirD, NirL, NirG and NirH. All proteins are required for the total conversion of siroheme to didecarboxysiroheme. http://togogenome.org/gene/1163748:MARHY_RS14500 ^@ http://purl.uniprot.org/uniprot/H8WER8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS08645 ^@ http://purl.uniprot.org/uniprot/H8WEP0 ^@ Similarity ^@ Belongs to the ETF beta-subunit/FixA family. http://togogenome.org/gene/1163748:MARHY_RS00690 ^@ http://purl.uniprot.org/uniprot/H8WBJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS12535 ^@ http://purl.uniprot.org/uniprot/H8WBA6 ^@ Similarity ^@ Belongs to the PhoH family. http://togogenome.org/gene/1163748:MARHY_RS00935 ^@ http://purl.uniprot.org/uniprot/H8WBQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS03590 ^@ http://purl.uniprot.org/uniprot/H8W5K9 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.|||In the C-terminal section; belongs to the NAD synthetase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS11535 ^@ http://purl.uniprot.org/uniprot/H8W974 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RdgC family.|||May be involved in recombination.|||nucleoid http://togogenome.org/gene/1163748:MARHY_RS00755 ^@ http://purl.uniprot.org/uniprot/H8WBL2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1163748:MARHY_RS15710 ^@ http://purl.uniprot.org/uniprot/H8W5Y2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiJ family.|||Cytoplasm|||Required for ubiquinone (coenzyme Q) biosynthesis. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates. http://togogenome.org/gene/1163748:MARHY_RS15210 ^@ http://purl.uniprot.org/uniprot/H8W4Q7 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/1163748:MARHY_RS00960 ^@ http://purl.uniprot.org/uniprot/H8WBQ5 ^@ Function|||Similarity ^@ Belongs to the esterase D family.|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/1163748:MARHY_RS17700 ^@ http://purl.uniprot.org/uniprot/H8W9E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS02245 ^@ http://purl.uniprot.org/uniprot/H8WEA7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNase PH family.|||Homohexameric ring arranged as a trimer of dimers.|||Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. http://togogenome.org/gene/1163748:MARHY_RS05600 ^@ http://purl.uniprot.org/uniprot/H8W926 ^@ Function|||Similarity ^@ Belongs to the cyanase family.|||Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. http://togogenome.org/gene/1163748:MARHY_RS16975 ^@ http://purl.uniprot.org/uniprot/H8W826 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.|||Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS12310 ^@ http://purl.uniprot.org/uniprot/H8WAP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZapG family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS16710 ^@ http://purl.uniprot.org/uniprot/H8W7G0 ^@ Similarity ^@ Belongs to the peptidase S11 family. http://togogenome.org/gene/1163748:MARHY_RS15140 ^@ http://purl.uniprot.org/uniprot/H8W4P3 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/1163748:MARHY_RS04465 ^@ http://purl.uniprot.org/uniprot/H8W704 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS00010 ^@ http://purl.uniprot.org/uniprot/H8WA81 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA. http://togogenome.org/gene/1163748:MARHY_RS06755 ^@ http://purl.uniprot.org/uniprot/H8WB94 ^@ Similarity ^@ Belongs to the PTPS family. QueD subfamily. http://togogenome.org/gene/1163748:MARHY_RS03375 ^@ http://purl.uniprot.org/uniprot/H8W5G6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.|||Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).|||Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS00525 ^@ http://purl.uniprot.org/uniprot/H8WB06 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/1163748:MARHY_RS10140 ^@ http://purl.uniprot.org/uniprot/H8W6K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal stress protein A family.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS06065 ^@ http://purl.uniprot.org/uniprot/H8WAD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial secretin family. GSP D subfamily.|||Cell outer membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS13540 ^@ http://purl.uniprot.org/uniprot/H8WCT7 ^@ Similarity ^@ Belongs to the adrenodoxin/putidaredoxin family. http://togogenome.org/gene/1163748:MARHY_RS12315 ^@ http://purl.uniprot.org/uniprot/H8WAP4 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/1163748:MARHY_RS07615 ^@ http://purl.uniprot.org/uniprot/H8WD55 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvC family.|||Binds 2 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/1163748:MARHY_RS12655 ^@ http://purl.uniprot.org/uniprot/H8WBD1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.|||Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS15275 ^@ http://purl.uniprot.org/uniprot/H8W581 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS16900 ^@ http://purl.uniprot.org/uniprot/H8W810 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/1163748:MARHY_RS11780 ^@ http://purl.uniprot.org/uniprot/H8W9T2 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS04885 ^@ http://purl.uniprot.org/uniprot/H8W863 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS10060 ^@ http://purl.uniprot.org/uniprot/H8W6I3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/1163748:MARHY_RS06825 ^@ http://purl.uniprot.org/uniprot/H8WBS0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase E/G family. RNase E subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per homotetramer.|||Cell inner membrane|||Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Within the RNA degradosome, RNase E assembles into a homotetramer formed by a dimer of dimers.|||Cytoplasm|||Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. http://togogenome.org/gene/1163748:MARHY_RS08850 ^@ http://purl.uniprot.org/uniprot/H8W4D1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TrkH potassium transport family.|||Cell inner membrane|||Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS15075 ^@ http://purl.uniprot.org/uniprot/H8W4N0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinylarginine dihydrolase family.|||Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS05655 ^@ http://purl.uniprot.org/uniprot/H8W9J4 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Cell inner membrane|||Homodimer.|||Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.|||The transmembrane domain is a dimerization domain. http://togogenome.org/gene/1163748:MARHY_RS09160 ^@ http://purl.uniprot.org/uniprot/H8W521 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS05175 ^@ http://purl.uniprot.org/uniprot/H8W8C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS04575 ^@ http://purl.uniprot.org/uniprot/H8W7I6 ^@ Function|||Similarity ^@ An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.|||Belongs to the SdhE FAD assembly factor family. http://togogenome.org/gene/1163748:MARHY_RS16865 ^@ http://purl.uniprot.org/uniprot/H8W803 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1163748:MARHY_RS12730 ^@ http://purl.uniprot.org/uniprot/H8WBE6 ^@ Similarity ^@ Belongs to the MotB family. http://togogenome.org/gene/1163748:MARHY_RS03865 ^@ http://purl.uniprot.org/uniprot/H8W674 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the GTP cyclohydrolase II family.|||Binds 1 zinc ion per subunit.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. http://togogenome.org/gene/1163748:MARHY_RS00875 ^@ http://purl.uniprot.org/uniprot/H8WBN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS09590 ^@ http://purl.uniprot.org/uniprot/H8W5S7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.|||Cell membrane|||Forms a complex with DabB.|||Part of an energy-coupled inorganic carbon pump. http://togogenome.org/gene/1163748:MARHY_RS05680 ^@ http://purl.uniprot.org/uniprot/H8W9J9 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/1163748:MARHY_RS03905 ^@ http://purl.uniprot.org/uniprot/H8W682 ^@ Function|||Similarity ^@ Belongs to the dihydrofolate reductase family.|||Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. http://togogenome.org/gene/1163748:MARHY_RS17520 ^@ http://purl.uniprot.org/uniprot/H8W8U9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Fur family.|||Binds 1 Mn(2+) or Fe(2+) ion per subunit.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS03630 ^@ http://purl.uniprot.org/uniprot/H8W5L8 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS14360 ^@ http://purl.uniprot.org/uniprot/H8WE81 ^@ Subcellular Location Annotation ^@ Cell inner membrane http://togogenome.org/gene/1163748:MARHY_RS10685 ^@ http://purl.uniprot.org/uniprot/H8W7T3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the OMP decarboxylase family. Type 1 subfamily.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS03525 ^@ http://purl.uniprot.org/uniprot/H8W5J6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell membrane|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/1163748:MARHY_RS16100 ^@ http://purl.uniprot.org/uniprot/H8W6M5 ^@ Similarity ^@ Belongs to the Dps family. http://togogenome.org/gene/1163748:MARHY_RS04665 ^@ http://purl.uniprot.org/uniprot/H8W7K7 ^@ Function|||Similarity ^@ Belongs to the esterase D family.|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/1163748:MARHY_RS16850 ^@ http://purl.uniprot.org/uniprot/H8W800 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS05960 ^@ http://purl.uniprot.org/uniprot/H8W9R0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS02770 ^@ http://purl.uniprot.org/uniprot/H8W468 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1163748:MARHY_RS12490 ^@ http://purl.uniprot.org/uniprot/H8WAS8 ^@ Function|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.|||This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/1163748:MARHY_RS06780 ^@ http://purl.uniprot.org/uniprot/H8WB99 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/1163748:MARHY_RS04485 ^@ http://purl.uniprot.org/uniprot/H8W708 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS17715 ^@ http://purl.uniprot.org/uniprot/H8W9E8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS04160 ^@ http://purl.uniprot.org/uniprot/H8W6U4 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/1163748:MARHY_RS07850 ^@ http://purl.uniprot.org/uniprot/H8WDA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial sugar transferase family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS17065 ^@ http://purl.uniprot.org/uniprot/H8W845 ^@ Subcellular Location Annotation ^@ Cell inner membrane http://togogenome.org/gene/1163748:MARHY_RS07560 ^@ http://purl.uniprot.org/uniprot/H8WCN3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS09930 ^@ http://purl.uniprot.org/uniprot/H8W6F6 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS16020 ^@ http://purl.uniprot.org/uniprot/H8W6K9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS15730 ^@ http://purl.uniprot.org/uniprot/H8W5Y6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatA/E family.|||Cell membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.|||The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. http://togogenome.org/gene/1163748:MARHY_RS09470 ^@ http://purl.uniprot.org/uniprot/H8W5Q2 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS09750 ^@ http://purl.uniprot.org/uniprot/H8W5V9 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS11995 ^@ http://purl.uniprot.org/uniprot/H8W9X5 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/1163748:MARHY_RS09690 ^@ http://purl.uniprot.org/uniprot/H8W5U7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Acts as a molecular motor to provide the energy that is required for assembly of the pseudopilus and the extrusion of substrates generated in the cytoplasm.|||Belongs to the GSP E family.|||Cell inner membrane http://togogenome.org/gene/1163748:MARHY_RS13085 ^@ http://purl.uniprot.org/uniprot/H8WC28 ^@ Similarity ^@ In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family. http://togogenome.org/gene/1163748:MARHY_RS03440 ^@ http://purl.uniprot.org/uniprot/H8W5H9 ^@ Function|||Similarity ^@ Belongs to the NusB family.|||Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. http://togogenome.org/gene/1163748:MARHY_RS01240 ^@ http://purl.uniprot.org/uniprot/H8WCC1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS09845 ^@ http://purl.uniprot.org/uniprot/H8W6D8 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/1163748:MARHY_RS03080 ^@ http://purl.uniprot.org/uniprot/H8W4U5 ^@ Function|||Similarity ^@ Belongs to the GlnE family.|||Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell. http://togogenome.org/gene/1163748:MARHY_RS02920 ^@ http://purl.uniprot.org/uniprot/H8W4A1 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/1163748:MARHY_RS16750 ^@ http://purl.uniprot.org/uniprot/H8W7H0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS00180 ^@ http://purl.uniprot.org/uniprot/H8WAB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MotA family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS16810 ^@ http://purl.uniprot.org/uniprot/H8W7Z2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS02600 ^@ http://purl.uniprot.org/uniprot/H8W440 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HemJ family.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|||Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS17555 ^@ http://purl.uniprot.org/uniprot/H8W9B3 ^@ Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase I family.|||Homopolymer. http://togogenome.org/gene/1163748:MARHY_RS01285 ^@ http://purl.uniprot.org/uniprot/H8WCD0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.|||Binds 1 FAD per subunit.|||May have a photoreceptor function. http://togogenome.org/gene/1163748:MARHY_RS00165 ^@ http://purl.uniprot.org/uniprot/H8WAB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUA5 family. TsaC subfamily.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. http://togogenome.org/gene/1163748:MARHY_RS07555 ^@ http://purl.uniprot.org/uniprot/H8WCN2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.|||Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.|||Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS03370 ^@ http://purl.uniprot.org/uniprot/H8W5G5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS16230 ^@ http://purl.uniprot.org/uniprot/H8W6Q1 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PdxA family.|||Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).|||Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).|||Cytoplasm|||Homodimer.|||The active site is located at the dimer interface. http://togogenome.org/gene/1163748:MARHY_RS02915 ^@ http://purl.uniprot.org/uniprot/H8W4A0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1163748:MARHY_RS05575 ^@ http://purl.uniprot.org/uniprot/H8W921 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/1163748:MARHY_RS03870 ^@ http://purl.uniprot.org/uniprot/H8W675 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family. DXPS subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS14495 ^@ http://purl.uniprot.org/uniprot/H8WER7 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/1163748:MARHY_RS04235 ^@ http://purl.uniprot.org/uniprot/H8W6V8 ^@ Function|||Similarity ^@ Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.|||Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. http://togogenome.org/gene/1163748:MARHY_RS14940 ^@ http://purl.uniprot.org/uniprot/H8W4K3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS16500 ^@ http://purl.uniprot.org/uniprot/H8W7B4 ^@ Caution|||Function|||Similarity ^@ Belongs to the dUTPase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/1163748:MARHY_RS04275 ^@ http://purl.uniprot.org/uniprot/H8W6W6 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/1163748:MARHY_RS07435 ^@ http://purl.uniprot.org/uniprot/H8WCK7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/1163748:MARHY_RS11460 ^@ http://purl.uniprot.org/uniprot/H8W959 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecX family.|||Cytoplasm|||Modulates RecA activity. http://togogenome.org/gene/1163748:MARHY_RS11475 ^@ http://purl.uniprot.org/uniprot/H8W962 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/1163748:MARHY_RS01780 ^@ http://purl.uniprot.org/uniprot/H8WD40 ^@ Function|||Similarity ^@ Belongs to the bacterioferritin family.|||Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex. http://togogenome.org/gene/1163748:MARHY_RS04215 ^@ http://purl.uniprot.org/uniprot/H8W6V4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LolB family.|||Cell outer membrane|||Membrane|||Monomer.|||Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. http://togogenome.org/gene/1163748:MARHY_RS08265 ^@ http://purl.uniprot.org/uniprot/H8WDZ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 1 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/1163748:MARHY_RS14275 ^@ http://purl.uniprot.org/uniprot/H8WE64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS09295 ^@ http://purl.uniprot.org/uniprot/H8W554 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS18280 ^@ http://purl.uniprot.org/uniprot/H8WA76 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/1163748:MARHY_RS09135 ^@ http://purl.uniprot.org/uniprot/H8W515 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS10080 ^@ http://purl.uniprot.org/uniprot/H8W6I7 ^@ Function|||Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family.|||E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). http://togogenome.org/gene/1163748:MARHY_RS14680 ^@ http://purl.uniprot.org/uniprot/H8WEV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS03415 ^@ http://purl.uniprot.org/uniprot/H8W5H4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS06430 ^@ http://purl.uniprot.org/uniprot/H8WB29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmC/CycZ/HelC family.|||Cell inner membrane|||Membrane|||Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. http://togogenome.org/gene/1163748:MARHY_RS08170 ^@ http://purl.uniprot.org/uniprot/H8WDX9 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS12675 ^@ http://purl.uniprot.org/uniprot/H8WBD5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. HflK subfamily.|||HflC and HflK could encode or regulate a protease.|||HflC and HflK may interact to form a multimeric complex.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS10340 ^@ http://purl.uniprot.org/uniprot/H8W750 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family. http://togogenome.org/gene/1163748:MARHY_RS09235 ^@ http://purl.uniprot.org/uniprot/H8W539 ^@ Function ^@ Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site. http://togogenome.org/gene/1163748:MARHY_RS01890 ^@ http://purl.uniprot.org/uniprot/H8WDM2 ^@ Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. http://togogenome.org/gene/1163748:MARHY_RS01105 ^@ http://purl.uniprot.org/uniprot/H8WC93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP38/TMEM64 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS08460 ^@ http://purl.uniprot.org/uniprot/H8WEK2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NfuA family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is presumably bound at the interface of two monomers.|||Homodimer.|||Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. http://togogenome.org/gene/1163748:MARHY_RS08320 ^@ http://purl.uniprot.org/uniprot/H8WE11 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS12585 ^@ http://purl.uniprot.org/uniprot/H8WBB7 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS05205 ^@ http://purl.uniprot.org/uniprot/H8W8D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS00240 ^@ http://purl.uniprot.org/uniprot/H8WAU5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Cell membrane|||Membrane|||Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). http://togogenome.org/gene/1163748:MARHY_RS16490 ^@ http://purl.uniprot.org/uniprot/H8W7B2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS10020 ^@ http://purl.uniprot.org/uniprot/H8W6H5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZipA family.|||Cell inner membrane|||Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.|||Interacts with FtsZ via their C-terminal domains. http://togogenome.org/gene/1163748:MARHY_RS04305 ^@ http://purl.uniprot.org/uniprot/H8W6X2 ^@ Function|||Subcellular Location Annotation ^@ Cell inner membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system. http://togogenome.org/gene/1163748:MARHY_RS15560 ^@ http://purl.uniprot.org/uniprot/H8W5E5 ^@ Cofactor|||Similarity ^@ Belongs to the bacterial PQQ dehydrogenase family.|||Binds 1 Ca(2+) ion per subunit.|||Binds 1 PQQ group per subunit. http://togogenome.org/gene/1163748:MARHY_RS01765 ^@ http://purl.uniprot.org/uniprot/H8WD37 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS08780 ^@ http://purl.uniprot.org/uniprot/H8W4B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS04190 ^@ http://purl.uniprot.org/uniprot/H8W6V0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/1163748:MARHY_RS03990 ^@ http://purl.uniprot.org/uniprot/H8W699 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase RlmH family.|||Cytoplasm|||Homodimer.|||Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. http://togogenome.org/gene/1163748:MARHY_RS12660 ^@ http://purl.uniprot.org/uniprot/H8WBD2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/1163748:MARHY_RS04145 ^@ http://purl.uniprot.org/uniprot/H8W6U1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS07525 ^@ http://purl.uniprot.org/uniprot/H8WCM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.|||Belongs to the KdsB family.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS08805 ^@ http://purl.uniprot.org/uniprot/H8W4C2 ^@ Similarity ^@ Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/1163748:MARHY_RS14730 ^@ http://purl.uniprot.org/uniprot/H8WEW4 ^@ Similarity ^@ Belongs to the thioester dehydratase family. FabA subfamily. http://togogenome.org/gene/1163748:MARHY_RS03790 ^@ http://purl.uniprot.org/uniprot/H8W659 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS00040 ^@ http://purl.uniprot.org/uniprot/H8WA87 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS08565 ^@ http://purl.uniprot.org/uniprot/H8WEM3 ^@ Similarity ^@ Belongs to the CFA/CMAS family. http://togogenome.org/gene/1163748:MARHY_RS16190 ^@ http://purl.uniprot.org/uniprot/H8W6P3 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1163748:MARHY_RS03060 ^@ http://purl.uniprot.org/uniprot/H8W4U0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS10085 ^@ http://purl.uniprot.org/uniprot/H8W6I8 ^@ Similarity ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. http://togogenome.org/gene/1163748:MARHY_RS12380 ^@ http://purl.uniprot.org/uniprot/H8WAQ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LptC family.|||Cell inner membrane|||Component of the lipopolysaccharide transport and assembly complex. Interacts with LptA and the LptBFG transporter complex.|||Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. http://togogenome.org/gene/1163748:MARHY_RS10210 ^@ http://purl.uniprot.org/uniprot/H8W724 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BamB family.|||Cell outer membrane|||Part of the Bam complex.|||Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. http://togogenome.org/gene/1163748:MARHY_RS04050 ^@ http://purl.uniprot.org/uniprot/H8W6B2 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-allosteric. http://togogenome.org/gene/1163748:MARHY_RS14995 ^@ http://purl.uniprot.org/uniprot/H8W4L4 ^@ Cofactor|||Function ^@ Binds 2 [4Fe-4S] clusters.|||Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. http://togogenome.org/gene/1163748:MARHY_RS11045 ^@ http://purl.uniprot.org/uniprot/H8W8G8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LptF/LptG family.|||Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).|||Membrane|||Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. http://togogenome.org/gene/1163748:MARHY_RS16195 ^@ http://purl.uniprot.org/uniprot/H8W6P4 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/1163748:MARHY_RS16930 ^@ http://purl.uniprot.org/uniprot/H8W816 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS03520 ^@ http://purl.uniprot.org/uniprot/H8W5J5 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS00990 ^@ http://purl.uniprot.org/uniprot/H8WBR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS16540 ^@ http://purl.uniprot.org/uniprot/H8W7C2 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/1163748:MARHY_RS10965 ^@ http://purl.uniprot.org/uniprot/H8W8F5 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/1163748:MARHY_RS04230 ^@ http://purl.uniprot.org/uniprot/H8W6V7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/1163748:MARHY_RS12590 ^@ http://purl.uniprot.org/uniprot/H8WBB8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS13435 ^@ http://purl.uniprot.org/uniprot/H8WCR5 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/1163748:MARHY_RS06090 ^@ http://purl.uniprot.org/uniprot/H8WAE1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS17395 ^@ http://purl.uniprot.org/uniprot/H8W8S3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the FPG family.|||Binds 1 zinc ion per subunit.|||Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS01840 ^@ http://purl.uniprot.org/uniprot/H8WDL2 ^@ Similarity ^@ Belongs to the Rsd/AlgQ family. http://togogenome.org/gene/1163748:MARHY_RS05835 ^@ http://purl.uniprot.org/uniprot/H8W9N0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS16420 ^@ http://purl.uniprot.org/uniprot/H8W798 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell inner membrane|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/1163748:MARHY_RS06305 ^@ http://purl.uniprot.org/uniprot/H8WAI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliQ/MopD/SpaQ family.|||Cell membrane|||Membrane|||Role in flagellar biosynthesis. http://togogenome.org/gene/1163748:MARHY_RS12420 ^@ http://purl.uniprot.org/uniprot/H8WAR5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS10130 ^@ http://purl.uniprot.org/uniprot/H8W6J9 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/1163748:MARHY_RS15250 ^@ http://purl.uniprot.org/uniprot/H8W576 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/1163748:MARHY_RS01365 ^@ http://purl.uniprot.org/uniprot/H8WCE6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS16240 ^@ http://purl.uniprot.org/uniprot/H8W6Q3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LptD family.|||Cell outer membrane|||Component of the lipopolysaccharide transport and assembly complex. Interacts with LptE and LptA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. http://togogenome.org/gene/1163748:MARHY_RS10290 ^@ http://purl.uniprot.org/uniprot/H8W740 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).|||Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1. http://togogenome.org/gene/1163748:MARHY_RS08830 ^@ http://purl.uniprot.org/uniprot/H8W4C7 ^@ Similarity ^@ Belongs to the disproportionating enzyme family. http://togogenome.org/gene/1163748:MARHY_RS16475 ^@ http://purl.uniprot.org/uniprot/H8W7A9 ^@ Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. ArgA subfamily.|||Cytoplasm|||In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role. http://togogenome.org/gene/1163748:MARHY_RS04495 ^@ http://purl.uniprot.org/uniprot/H8W711 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule. http://togogenome.org/gene/1163748:MARHY_RS11685 ^@ http://purl.uniprot.org/uniprot/H8W9A3 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/1163748:MARHY_RS16740 ^@ http://purl.uniprot.org/uniprot/H8W7G8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS17870 ^@ http://purl.uniprot.org/uniprot/H8W9I0 ^@ Similarity ^@ Belongs to the Lgt family. http://togogenome.org/gene/1163748:MARHY_RS12775 ^@ http://purl.uniprot.org/uniprot/H8WBF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.|||Cell membrane|||Heterotetramer composed of ParC and ParE.|||Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. http://togogenome.org/gene/1163748:MARHY_RS01255 ^@ http://purl.uniprot.org/uniprot/H8WCC4 ^@ Similarity ^@ Belongs to the MotB family. http://togogenome.org/gene/1163748:MARHY_RS13285 ^@ http://purl.uniprot.org/uniprot/H8WC69 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS15880 ^@ http://purl.uniprot.org/uniprot/H8W619 ^@ Similarity ^@ Belongs to the transcriptional regulatory Fis family. http://togogenome.org/gene/1163748:MARHY_RS04020 ^@ http://purl.uniprot.org/uniprot/H8W6A5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LipB family.|||Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.|||Cytoplasm|||In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. http://togogenome.org/gene/1163748:MARHY_RS00365 ^@ http://purl.uniprot.org/uniprot/H8WAX2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter large permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/1163748:MARHY_RS15715 ^@ http://purl.uniprot.org/uniprot/H8W5Y3 ^@ Function|||Similarity ^@ Belongs to the ABC1 family. UbiB subfamily.|||Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. http://togogenome.org/gene/1163748:MARHY_RS04795 ^@ http://purl.uniprot.org/uniprot/H8W7N4 ^@ Function|||Similarity ^@ Belongs to the aspartate/glutamate racemases family.|||Provides the (R)-glutamate required for cell wall biosynthesis. http://togogenome.org/gene/1163748:MARHY_RS06925 ^@ http://purl.uniprot.org/uniprot/H8WBU1 ^@ Similarity ^@ Belongs to the ferredoxin--NADP reductase type 1 family. http://togogenome.org/gene/1163748:MARHY_RS10720 ^@ http://purl.uniprot.org/uniprot/H8W7U1 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS03570 ^@ http://purl.uniprot.org/uniprot/H8W5K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP H family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS13155 ^@ http://purl.uniprot.org/uniprot/H8WC42 ^@ Function|||Similarity ^@ Belongs to the nucleoside phosphorylase PpnP family.|||Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. http://togogenome.org/gene/1163748:MARHY_RS06535 ^@ http://purl.uniprot.org/uniprot/H8WB51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS00740 ^@ http://purl.uniprot.org/uniprot/H8WBK9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the pyridoxamine 5'-phosphate oxidase family.|||Binds 1 FMN per subunit.|||Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS03775 ^@ http://purl.uniprot.org/uniprot/H8W656 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurE subfamily.|||Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.|||Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS11260 ^@ http://purl.uniprot.org/uniprot/H8W8L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KdsA family.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS02790 ^@ http://purl.uniprot.org/uniprot/H8W460 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/1163748:MARHY_RS02880 ^@ http://purl.uniprot.org/uniprot/H8W491 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/1163748:MARHY_RS15445 ^@ http://purl.uniprot.org/uniprot/H8W5C2 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Cytoplasm|||Homotetramer.|||Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.|||There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors. http://togogenome.org/gene/1163748:MARHY_RS15165 ^@ http://purl.uniprot.org/uniprot/H8W4P8 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS08965 ^@ http://purl.uniprot.org/uniprot/H8W4G2 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/1163748:MARHY_RS03315 ^@ http://purl.uniprot.org/uniprot/H8W4Z2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS14225 ^@ http://purl.uniprot.org/uniprot/H8WE54 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 3 family. http://togogenome.org/gene/1163748:MARHY_RS02805 ^@ http://purl.uniprot.org/uniprot/H8W476 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1163748:MARHY_RS13395 ^@ http://purl.uniprot.org/uniprot/H8WCQ5 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/1163748:MARHY_RS10180 ^@ http://purl.uniprot.org/uniprot/H8W718 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily. http://togogenome.org/gene/1163748:MARHY_RS02785 ^@ http://purl.uniprot.org/uniprot/H8W471 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS13340 ^@ http://purl.uniprot.org/uniprot/H8WCP2 ^@ Similarity ^@ Belongs to the UPF0065 (bug) family. http://togogenome.org/gene/1163748:MARHY_RS03850 ^@ http://purl.uniprot.org/uniprot/H8W671 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/1163748:MARHY_RS04085 ^@ http://purl.uniprot.org/uniprot/H8W6B9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.|||Cytoplasm|||Specifically methylates the ribose of guanosine 2251 in 23S rRNA. http://togogenome.org/gene/1163748:MARHY_RS17335 ^@ http://purl.uniprot.org/uniprot/H8W8R0 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family. GreB subfamily.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length. http://togogenome.org/gene/1163748:MARHY_RS02830 ^@ http://purl.uniprot.org/uniprot/H8W481 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/1163748:MARHY_RS10730 ^@ http://purl.uniprot.org/uniprot/H8W7U3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS15395 ^@ http://purl.uniprot.org/uniprot/H8W5B1 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/1163748:MARHY_RS13980 ^@ http://purl.uniprot.org/uniprot/H8WDJ1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the urease beta subunit family.|||Cytoplasm|||Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. http://togogenome.org/gene/1163748:MARHY_RS09725 ^@ http://purl.uniprot.org/uniprot/H8W5V4 ^@ Similarity ^@ Belongs to the MbcT/ParT/Res family. http://togogenome.org/gene/1163748:MARHY_RS18240 ^@ http://purl.uniprot.org/uniprot/H8WA68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. http://togogenome.org/gene/1163748:MARHY_RS16290 ^@ http://purl.uniprot.org/uniprot/H8W6R4 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/1163748:MARHY_RS14815 ^@ http://purl.uniprot.org/uniprot/H8WEY1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.|||Cytoplasm|||Homodimer.|||Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. http://togogenome.org/gene/1163748:MARHY_RS10765 ^@ http://purl.uniprot.org/uniprot/H8W7V0 ^@ Similarity ^@ Belongs to the peptidase S16 family. http://togogenome.org/gene/1163748:MARHY_RS12810 ^@ http://purl.uniprot.org/uniprot/H8WBG2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type II topoisomerase GyrB family.|||Belongs to the type II topoisomerase family. ParE type 1 subfamily.|||Heterotetramer composed of ParC and ParE.|||Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. http://togogenome.org/gene/1163748:MARHY_RS12225 ^@ http://purl.uniprot.org/uniprot/H8WAM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP E family.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS06565 ^@ http://purl.uniprot.org/uniprot/H8WB57 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrB/RnfD family.|||Cell membrane|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. http://togogenome.org/gene/1163748:MARHY_RS04535 ^@ http://purl.uniprot.org/uniprot/H8W7H8 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/1163748:MARHY_RS16460 ^@ http://purl.uniprot.org/uniprot/H8W7A6 ^@ Similarity ^@ Belongs to the phosphoribulokinase family. http://togogenome.org/gene/1163748:MARHY_RS10260 ^@ http://purl.uniprot.org/uniprot/H8W734 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/1163748:MARHY_RS03900 ^@ http://purl.uniprot.org/uniprot/H8W681 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS14065 ^@ http://purl.uniprot.org/uniprot/H8WE21 ^@ Function|||Similarity ^@ Belongs to the TrhO family.|||Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs. http://togogenome.org/gene/1163748:MARHY_RS02190 ^@ http://purl.uniprot.org/uniprot/H8WDT4 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/1163748:MARHY_RS12250 ^@ http://purl.uniprot.org/uniprot/H8WAN1 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/1163748:MARHY_RS08670 ^@ http://purl.uniprot.org/uniprot/H8WEP5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS16770 ^@ http://purl.uniprot.org/uniprot/H8W7Y4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CysZ family.|||Cell inner membrane|||High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway. http://togogenome.org/gene/1163748:MARHY_RS15430 ^@ http://purl.uniprot.org/uniprot/H8W5B9 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/1163748:MARHY_RS10360 ^@ http://purl.uniprot.org/uniprot/H8W754 ^@ Cofactor|||Similarity ^@ Belongs to the nitroreductase family.|||Binds 1 FMN per subunit. http://togogenome.org/gene/1163748:MARHY_RS06240 ^@ http://purl.uniprot.org/uniprot/H8WAG8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliG family.|||Cell inner membrane|||FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS16200 ^@ http://purl.uniprot.org/uniprot/H8W6P5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoid occlusion factor SlmA family.|||Homodimer. Interacts with FtsZ.|||Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.|||nucleoid http://togogenome.org/gene/1163748:MARHY_RS15330 ^@ http://purl.uniprot.org/uniprot/H8W592 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS09225 ^@ http://purl.uniprot.org/uniprot/H8W537 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MerP family.|||Involved in mercury resistance. Acts as a mercury scavenger that specifically binds to a mercuric ion in the periplasm and probably passes it to the cytoplasmic mercuric reductase MerA via the mercuric transport protein MerT.|||Monomer.|||Periplasm http://togogenome.org/gene/1163748:MARHY_RS17800 ^@ http://purl.uniprot.org/uniprot/H8W9G6 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS04675 ^@ http://purl.uniprot.org/uniprot/H8W7K9 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS02760 ^@ http://purl.uniprot.org/uniprot/H8W466 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/1163748:MARHY_RS08795 ^@ http://purl.uniprot.org/uniprot/H8W4C0 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/1163748:MARHY_RS05190 ^@ http://purl.uniprot.org/uniprot/H8W8C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS03985 ^@ http://purl.uniprot.org/uniprot/H8W698 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Iojap/RsfS family.|||Cytoplasm|||Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.|||Interacts with ribosomal protein uL14 (rplN). http://togogenome.org/gene/1163748:MARHY_RS12920 ^@ http://purl.uniprot.org/uniprot/H8WBZ3 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ 2 residues (Tyr-54 and Arg-57) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.|||Belongs to the sirtuin family. Class III subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. http://togogenome.org/gene/1163748:MARHY_RS11200 ^@ http://purl.uniprot.org/uniprot/H8W8K1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/1163748:MARHY_RS12680 ^@ http://purl.uniprot.org/uniprot/H8WBD6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/1163748:MARHY_RS08650 ^@ http://purl.uniprot.org/uniprot/H8WEP1 ^@ Cofactor|||Similarity ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer. http://togogenome.org/gene/1163748:MARHY_RS13105 ^@ http://purl.uniprot.org/uniprot/H8WC32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.|||Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS07595 ^@ http://purl.uniprot.org/uniprot/H8WD51 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS13145 ^@ http://purl.uniprot.org/uniprot/H8WC40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.|||Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS03610 ^@ http://purl.uniprot.org/uniprot/H8W5L3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ClpA/ClpB family.|||Cytoplasm|||Homohexamer. The oligomerization is ATP-dependent.|||Homohexamer; The oligomerization is ATP-dependent.|||Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. http://togogenome.org/gene/1163748:MARHY_RS07690 ^@ http://purl.uniprot.org/uniprot/H8WD68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS11575 ^@ http://purl.uniprot.org/uniprot/H8W982 ^@ Function|||Similarity ^@ Belongs to the peptidase M16 family.|||Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin. http://togogenome.org/gene/1163748:MARHY_RS15725 ^@ http://purl.uniprot.org/uniprot/H8W5Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA-PH family.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS16085 ^@ http://purl.uniprot.org/uniprot/H8W6M2 ^@ Subcellular Location Annotation ^@ Cell outer membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS05695 ^@ http://purl.uniprot.org/uniprot/H8W9K2 ^@ Similarity ^@ Belongs to the PhzF family. http://togogenome.org/gene/1163748:MARHY_RS11180 ^@ http://purl.uniprot.org/uniprot/H8W8J7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.|||Binds 2 [4Fe-4S] clusters per subunit.|||Cell inner membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/1163748:MARHY_RS17060 ^@ http://purl.uniprot.org/uniprot/H8W844 ^@ Function|||Similarity ^@ Belongs to the aconitase/IPM isomerase family.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. http://togogenome.org/gene/1163748:MARHY_RS03875 ^@ http://purl.uniprot.org/uniprot/H8W676 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/1163748:MARHY_RS02175 ^@ http://purl.uniprot.org/uniprot/H8WDT1 ^@ Similarity ^@ Belongs to the YggT family. http://togogenome.org/gene/1163748:MARHY_RS11040 ^@ http://purl.uniprot.org/uniprot/H8W8G7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS02850 ^@ http://purl.uniprot.org/uniprot/H8W485 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/1163748:MARHY_RS15290 ^@ http://purl.uniprot.org/uniprot/H8W584 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/1163748:MARHY_RS07305 ^@ http://purl.uniprot.org/uniprot/H8WCH9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.|||Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS08235 ^@ http://purl.uniprot.org/uniprot/H8WDZ2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS09595 ^@ http://purl.uniprot.org/uniprot/H8W5S8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the inorganic carbon transporter (TC 9.A.2) DabB family.|||Cell membrane|||Forms a complex with DabA.|||Membrane|||Part of an energy-coupled inorganic carbon pump. http://togogenome.org/gene/1163748:MARHY_RS07070 ^@ http://purl.uniprot.org/uniprot/H8WBW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial glucokinase family.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS03960 ^@ http://purl.uniprot.org/uniprot/H8W693 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DedA family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS13350 ^@ http://purl.uniprot.org/uniprot/H8WCP5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS02765 ^@ http://purl.uniprot.org/uniprot/H8W467 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1163748:MARHY_RS04525 ^@ http://purl.uniprot.org/uniprot/H8W7H6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thioredoxin family. DsbC subfamily.|||Periplasm|||Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. http://togogenome.org/gene/1163748:MARHY_RS17795 ^@ http://purl.uniprot.org/uniprot/H8W9G5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS03715 ^@ http://purl.uniprot.org/uniprot/H8W5N2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.|||Membrane|||The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein. http://togogenome.org/gene/1163748:MARHY_RS08435 ^@ http://purl.uniprot.org/uniprot/H8WEJ6 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/1163748:MARHY_RS12340 ^@ http://purl.uniprot.org/uniprot/H8WAP9 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/1163748:MARHY_RS08405 ^@ http://purl.uniprot.org/uniprot/H8WEJ0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Binds 2 Zn(2+) ions per subunit.|||Monomer.|||Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. http://togogenome.org/gene/1163748:MARHY_RS03595 ^@ http://purl.uniprot.org/uniprot/H8W5L0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BamD family.|||Cell outer membrane|||Part of the Bam complex.|||Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. http://togogenome.org/gene/1163748:MARHY_RS16920 ^@ http://purl.uniprot.org/uniprot/H8W814 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS00630 ^@ http://purl.uniprot.org/uniprot/H8WBI6 ^@ Similarity ^@ Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family. http://togogenome.org/gene/1163748:MARHY_RS14885 ^@ http://purl.uniprot.org/uniprot/H8W4J3 ^@ Function|||Similarity ^@ Belongs to the Fe(2+)-trafficking protein family.|||Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. http://togogenome.org/gene/1163748:MARHY_RS05055 ^@ http://purl.uniprot.org/uniprot/H8W8A1 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/1163748:MARHY_RS02480 ^@ http://purl.uniprot.org/uniprot/H8WEG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI family.|||Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS11500 ^@ http://purl.uniprot.org/uniprot/H8W967 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS09575 ^@ http://purl.uniprot.org/uniprot/H8W5S4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.|||Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.|||The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP). http://togogenome.org/gene/1163748:MARHY_RS03755 ^@ http://purl.uniprot.org/uniprot/H8W652 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MraZ family.|||Forms oligomers.|||nucleoid http://togogenome.org/gene/1163748:MARHY_RS06740 ^@ http://purl.uniprot.org/uniprot/H8WB93 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS14635 ^@ http://purl.uniprot.org/uniprot/H8WEU5 ^@ Similarity|||Subunit ^@ Belongs to the Ahb/Nir family.|||Probably forms a complex composed of NirD, NirL, NirG and NirH. All proteins are required for the total conversion of siroheme to didecarboxysiroheme. http://togogenome.org/gene/1163748:MARHY_RS14005 ^@ http://purl.uniprot.org/uniprot/H8WDJ7 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS00320 ^@ http://purl.uniprot.org/uniprot/H8WAW1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS03495 ^@ http://purl.uniprot.org/uniprot/H8W5I9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS04700 ^@ http://purl.uniprot.org/uniprot/H8W7L5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribonuclease III family.|||Cytoplasm|||Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS02745 ^@ http://purl.uniprot.org/uniprot/H8W463 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/1163748:MARHY_RS09125 ^@ http://purl.uniprot.org/uniprot/H8W513 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS14490 ^@ http://purl.uniprot.org/uniprot/H8WER6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase U32 family. UbiU subfamily.|||Forms an heterodimer with UbiV.|||Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiV, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway. http://togogenome.org/gene/1163748:MARHY_RS15925 ^@ http://purl.uniprot.org/uniprot/H8W629 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS11980 ^@ http://purl.uniprot.org/uniprot/H8W9X2 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/1163748:MARHY_RS02985 ^@ http://purl.uniprot.org/uniprot/H8W4S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS12685 ^@ http://purl.uniprot.org/uniprot/H8WBD7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Hfq family.|||Homohexamer.|||RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. http://togogenome.org/gene/1163748:MARHY_RS16265 ^@ http://purl.uniprot.org/uniprot/H8W6Q9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit.|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. http://togogenome.org/gene/1163748:MARHY_RS04850 ^@ http://purl.uniprot.org/uniprot/H8W7P6 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1163748:MARHY_RS06785 ^@ http://purl.uniprot.org/uniprot/H8WBA0 ^@ Function|||Similarity ^@ Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.|||Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. http://togogenome.org/gene/1163748:MARHY_RS00610 ^@ http://purl.uniprot.org/uniprot/H8WB22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS03285 ^@ http://purl.uniprot.org/uniprot/H8W4Y6 ^@ Function|||Similarity ^@ Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.|||Belongs to the Nudix hydrolase family. RppH subfamily. http://togogenome.org/gene/1163748:MARHY_RS01390 ^@ http://purl.uniprot.org/uniprot/H8WCF1 ^@ PTM ^@ Binds 1 heme group per subunit. http://togogenome.org/gene/1163748:MARHY_RS00280 ^@ http://purl.uniprot.org/uniprot/H8WAV3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.|||Cell membrane|||Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS06970 ^@ http://purl.uniprot.org/uniprot/H8WBV0 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS06445 ^@ http://purl.uniprot.org/uniprot/H8WB32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS07630 ^@ http://purl.uniprot.org/uniprot/H8WD58 ^@ Similarity ^@ Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. http://togogenome.org/gene/1163748:MARHY_RS05745 ^@ http://purl.uniprot.org/uniprot/H8W9L2 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/1163748:MARHY_RS02185 ^@ http://purl.uniprot.org/uniprot/H8WDT3 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. http://togogenome.org/gene/1163748:MARHY_RS04520 ^@ http://purl.uniprot.org/uniprot/H8W7H5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerD subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/1163748:MARHY_RS15135 ^@ http://purl.uniprot.org/uniprot/H8W4P2 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/1163748:MARHY_RS12525 ^@ http://purl.uniprot.org/uniprot/H8WBA4 ^@ Caution|||Function|||Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.|||Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS08160 ^@ http://purl.uniprot.org/uniprot/H8WDX7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the helicase family. DinG subfamily. Type 1 sub-subfamily.|||Binds 1 [4Fe-4S] cluster.|||DNA-dependent ATPase and 5'-3' DNA helicase. http://togogenome.org/gene/1163748:MARHY_RS17385 ^@ http://purl.uniprot.org/uniprot/H8W8S1 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. RsmD family.|||Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle. http://togogenome.org/gene/1163748:MARHY_RS05300 ^@ http://purl.uniprot.org/uniprot/H8W8W1 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS01975 ^@ http://purl.uniprot.org/uniprot/H8WDN9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/1163748:MARHY_RS02250 ^@ http://purl.uniprot.org/uniprot/H8WEA8 ^@ Similarity ^@ Belongs to the YicC/YloC family. http://togogenome.org/gene/1163748:MARHY_RS08615 ^@ http://purl.uniprot.org/uniprot/H8WEN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS12450 ^@ http://purl.uniprot.org/uniprot/H8WAS1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MreD family.|||Cell inner membrane|||Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS08720 ^@ http://purl.uniprot.org/uniprot/H8W4A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS02725 ^@ http://purl.uniprot.org/uniprot/H8W460 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/1163748:MARHY_RS08685 ^@ http://purl.uniprot.org/uniprot/H8WEP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 1 family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS00300 ^@ http://purl.uniprot.org/uniprot/H8WAV7 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/1163748:MARHY_RS12170 ^@ http://purl.uniprot.org/uniprot/H8WAL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS03470 ^@ http://purl.uniprot.org/uniprot/H8W5I4 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS17975 ^@ http://purl.uniprot.org/uniprot/H8WA11 ^@ Similarity ^@ Belongs to the Gfa family. http://togogenome.org/gene/1163748:MARHY_RS09285 ^@ http://purl.uniprot.org/uniprot/H8W550 ^@ Similarity ^@ Belongs to the PhzF family. http://togogenome.org/gene/1163748:MARHY_RS06580 ^@ http://purl.uniprot.org/uniprot/H8WB60 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell membrane|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||Membrane|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. http://togogenome.org/gene/1163748:MARHY_RS12375 ^@ http://purl.uniprot.org/uniprot/H8WAQ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the KdsC family.|||Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.|||Homotetramer. http://togogenome.org/gene/1163748:MARHY_RS13100 ^@ http://purl.uniprot.org/uniprot/H8WC31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS12740 ^@ http://purl.uniprot.org/uniprot/H8WBE8 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).|||Cell membrane|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase. http://togogenome.org/gene/1163748:MARHY_RS05125 ^@ http://purl.uniprot.org/uniprot/H8W8B5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS05615 ^@ http://purl.uniprot.org/uniprot/H8W929 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/1163748:MARHY_RS15545 ^@ http://purl.uniprot.org/uniprot/H8W5E2 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS08490 ^@ http://purl.uniprot.org/uniprot/H8WEK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DsrE/TusD family.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS00020 ^@ http://purl.uniprot.org/uniprot/H8WA83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/1163748:MARHY_RS16760 ^@ http://purl.uniprot.org/uniprot/H8W7Y2 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS03485 ^@ http://purl.uniprot.org/uniprot/H8W5I7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/1163748:MARHY_RS15860 ^@ http://purl.uniprot.org/uniprot/H8W615 ^@ Function|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.|||This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/1163748:MARHY_RS04530 ^@ http://purl.uniprot.org/uniprot/H8W7H7 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS07055 ^@ http://purl.uniprot.org/uniprot/H8WBW5 ^@ Similarity ^@ Belongs to the KHG/KDPG aldolase family. http://togogenome.org/gene/1163748:MARHY_RS02465 ^@ http://purl.uniprot.org/uniprot/H8WEF7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsY family.|||Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Probably interacts with PlsX. http://togogenome.org/gene/1163748:MARHY_RS10500 ^@ http://purl.uniprot.org/uniprot/H8W783 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS15575 ^@ http://purl.uniprot.org/uniprot/H8W5E8 ^@ Cofactor|||Similarity ^@ Belongs to the bacterial PQQ dehydrogenase family.|||Binds 1 Ca(2+) ion per subunit.|||Binds 1 PQQ group per subunit. http://togogenome.org/gene/1163748:MARHY_RS10545 ^@ http://purl.uniprot.org/uniprot/H8W7Q5 ^@ Function|||Similarity ^@ Belongs to the Dus family. DusC subfamily.|||Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. http://togogenome.org/gene/1163748:MARHY_RS18310 ^@ http://purl.uniprot.org/uniprot/H8WAT5 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS11275 ^@ http://purl.uniprot.org/uniprot/H8W8L6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccA family.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS09580 ^@ http://purl.uniprot.org/uniprot/H8W5S5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Membrane|||Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.|||The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP). http://togogenome.org/gene/1163748:MARHY_RS10445 ^@ http://purl.uniprot.org/uniprot/H8W772 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase class-2 family.|||Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. http://togogenome.org/gene/1163748:MARHY_RS04785 ^@ http://purl.uniprot.org/uniprot/H8W7N2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Cell membrane|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/1163748:MARHY_RS09850 ^@ http://purl.uniprot.org/uniprot/H8W6D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AzlC family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS04515 ^@ http://purl.uniprot.org/uniprot/H8W7H4 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/1163748:MARHY_RS08755 ^@ http://purl.uniprot.org/uniprot/H8W4B1 ^@ Similarity ^@ Belongs to the phosphate/phosphite/phosphonate binding protein family. http://togogenome.org/gene/1163748:MARHY_RS03600 ^@ http://purl.uniprot.org/uniprot/H8W5L1 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/1163748:MARHY_RS17390 ^@ http://purl.uniprot.org/uniprot/H8W8S2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS15370 ^@ http://purl.uniprot.org/uniprot/H8W5A6 ^@ Similarity ^@ Belongs to the SOS response-associated peptidase family. http://togogenome.org/gene/1163748:MARHY_RS01510 ^@ http://purl.uniprot.org/uniprot/H8WCY7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter large permease family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/1163748:MARHY_RS13665 ^@ http://purl.uniprot.org/uniprot/H8WDC3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial microcompartment|||Belongs to the EutB family.|||Binds between the large and small subunits.|||Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.|||The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards. http://togogenome.org/gene/1163748:MARHY_RS08360 ^@ http://purl.uniprot.org/uniprot/H8WEI0 ^@ Function|||Similarity ^@ Belongs to the class-I DAHP synthase family.|||Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). http://togogenome.org/gene/1163748:MARHY_RS01060 ^@ http://purl.uniprot.org/uniprot/H8WC84 ^@ Caution|||Similarity ^@ Belongs to the CobB/CobQ family. CobQ subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS07640 ^@ http://purl.uniprot.org/uniprot/H8WD60 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ExbD/TolR family.|||Cell inner membrane|||Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.|||The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer. http://togogenome.org/gene/1163748:MARHY_RS06530 ^@ http://purl.uniprot.org/uniprot/H8WB50 ^@ Similarity ^@ Belongs to the YkuD family. http://togogenome.org/gene/1163748:MARHY_RS14455 ^@ http://purl.uniprot.org/uniprot/H8WEQ9 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS01170 ^@ http://purl.uniprot.org/uniprot/H8WCA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS01420 ^@ http://purl.uniprot.org/uniprot/H8WCW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EamA transporter family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS06440 ^@ http://purl.uniprot.org/uniprot/H8WB31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmE/CycJ family.|||Cell membrane|||Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. http://togogenome.org/gene/1163748:MARHY_RS11170 ^@ http://purl.uniprot.org/uniprot/H8W8J5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell inner membrane|||Membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/1163748:MARHY_RS15325 ^@ http://purl.uniprot.org/uniprot/H8W591 ^@ Similarity ^@ Belongs to the ribosome association toxin RatA family. http://togogenome.org/gene/1163748:MARHY_RS07440 ^@ http://purl.uniprot.org/uniprot/H8WCK8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the R-transferase family. Bpt subfamily.|||Cytoplasm|||Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate. http://togogenome.org/gene/1163748:MARHY_RS01785 ^@ http://purl.uniprot.org/uniprot/H8WD41 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/1163748:MARHY_RS16235 ^@ http://purl.uniprot.org/uniprot/H8W6Q2 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.|||Periplasm|||The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition. http://togogenome.org/gene/1163748:MARHY_RS08710 ^@ http://purl.uniprot.org/uniprot/H8WEQ4 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/1163748:MARHY_RS06960 ^@ http://purl.uniprot.org/uniprot/H8WBU8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LpxH family.|||Belongs to the metallophosphoesterase superfamily. YfcE family.|||Binds 2 Mn(2+) ions per subunit in a binuclear metal center.|||Cell inner membrane|||Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. http://togogenome.org/gene/1163748:MARHY_RS03820 ^@ http://purl.uniprot.org/uniprot/H8W665 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.|||Cell membrane|||Self-interacts. Interacts with FtsZ. http://togogenome.org/gene/1163748:MARHY_RS03720 ^@ http://purl.uniprot.org/uniprot/H8W645 ^@ Cofactor ^@ Binds 1 heme c group covalently per subunit. http://togogenome.org/gene/1163748:MARHY_RS03685 ^@ http://purl.uniprot.org/uniprot/H8W5M6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Acetylates the N-terminal alanine of ribosomal protein bS18.|||Belongs to the acetyltransferase family. RimI subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS04825 ^@ http://purl.uniprot.org/uniprot/H8W7P0 ^@ Similarity ^@ Belongs to the fatty acyl-CoA reductase family. http://togogenome.org/gene/1163748:MARHY_RS01025 ^@ http://purl.uniprot.org/uniprot/H8WC76 ^@ Function|||Similarity ^@ Belongs to the CobT family.|||Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). http://togogenome.org/gene/1163748:MARHY_RS11135 ^@ http://purl.uniprot.org/uniprot/H8W8I7 ^@ Function|||Similarity ^@ Belongs to the GART family.|||Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. http://togogenome.org/gene/1163748:MARHY_RS14850 ^@ http://purl.uniprot.org/uniprot/H8W4I6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/1163748:MARHY_RS18245 ^@ http://purl.uniprot.org/uniprot/H8WA69 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS09655 ^@ http://purl.uniprot.org/uniprot/H8W5U0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP L family.|||Cell inner membrane|||Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS04780 ^@ http://purl.uniprot.org/uniprot/H8W7N1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmJ family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the guanosine in position 1516 of 16S rRNA. http://togogenome.org/gene/1163748:MARHY_RS15055 ^@ http://purl.uniprot.org/uniprot/H8W4M6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.|||Binds 1 zinc ion per subunit.|||Transforms N(2)-succinylglutamate into succinate and glutamate. http://togogenome.org/gene/1163748:MARHY_RS07395 ^@ http://purl.uniprot.org/uniprot/H8WCJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HflD family.|||Cell membrane|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS10335 ^@ http://purl.uniprot.org/uniprot/H8W749 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family. http://togogenome.org/gene/1163748:MARHY_RS05860 ^@ http://purl.uniprot.org/uniprot/H8W9N6 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/1163748:MARHY_RS07760 ^@ http://purl.uniprot.org/uniprot/H8WD82 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/1163748:MARHY_RS16005 ^@ http://purl.uniprot.org/uniprot/H8W6K5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS14190 ^@ http://purl.uniprot.org/uniprot/H8WE47 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS05890 ^@ http://purl.uniprot.org/uniprot/H8W9P3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS11155 ^@ http://purl.uniprot.org/uniprot/H8W8J1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Catalyzes the deamination of dCTP to dUTP.|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS15460 ^@ http://purl.uniprot.org/uniprot/H8W5C5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS06450 ^@ http://purl.uniprot.org/uniprot/H8WB33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the thioredoxin family. DsbE subfamily.|||Cell inner membrane http://togogenome.org/gene/1163748:MARHY_RS15755 ^@ http://purl.uniprot.org/uniprot/H8W5Z1 ^@ Similarity ^@ Belongs to the UbiH/COQ6 family. http://togogenome.org/gene/1163748:MARHY_RS16660 ^@ http://purl.uniprot.org/uniprot/H8W7E9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiC family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway. http://togogenome.org/gene/1163748:MARHY_RS03795 ^@ http://purl.uniprot.org/uniprot/H8W660 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEDS family. FtsW subfamily.|||Cell inner membrane|||Membrane|||Peptidoglycan polymerase that is essential for cell division. http://togogenome.org/gene/1163748:MARHY_RS00140 ^@ http://purl.uniprot.org/uniprot/H8WAA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Cytoplasm|||Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. http://togogenome.org/gene/1163748:MARHY_RS14880 ^@ http://purl.uniprot.org/uniprot/H8W4J2 ^@ Cofactor|||Function|||Similarity ^@ Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).|||Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/1163748:MARHY_RS07450 ^@ http://purl.uniprot.org/uniprot/H8WCL0 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS05200 ^@ http://purl.uniprot.org/uniprot/H8W8D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS04265 ^@ http://purl.uniprot.org/uniprot/H8W6W4 ^@ Cofactor|||Similarity ^@ Belongs to the RimK family.|||Binds 2 magnesium or manganese ions per subunit. http://togogenome.org/gene/1163748:MARHY_RS10710 ^@ http://purl.uniprot.org/uniprot/H8W7T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS03945 ^@ http://purl.uniprot.org/uniprot/H8W690 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS06290 ^@ http://purl.uniprot.org/uniprot/H8WAH9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliN/MopA/SpaO family.|||Cell membrane|||FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS18335 ^@ http://purl.uniprot.org/uniprot/H8WAU0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RnpA family.|||Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.|||RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. http://togogenome.org/gene/1163748:MARHY_RS05975 ^@ http://purl.uniprot.org/uniprot/H8W9R2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS16895 ^@ http://purl.uniprot.org/uniprot/H8W809 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS15425 ^@ http://purl.uniprot.org/uniprot/H8W5B8 ^@ Cofactor|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein. http://togogenome.org/gene/1163748:MARHY_RS04540 ^@ http://purl.uniprot.org/uniprot/H8W7H9 ^@ Similarity ^@ Belongs to the RecJ family. http://togogenome.org/gene/1163748:MARHY_RS03895 ^@ http://purl.uniprot.org/uniprot/H8W680 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS17985 ^@ http://purl.uniprot.org/uniprot/H8WA13 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS00465 ^@ http://purl.uniprot.org/uniprot/H8WAZ3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS08640 ^@ http://purl.uniprot.org/uniprot/H8WEN8 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/1163748:MARHY_RS02285 ^@ http://purl.uniprot.org/uniprot/H8WEB5 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS01250 ^@ http://purl.uniprot.org/uniprot/H8WCC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS04105 ^@ http://purl.uniprot.org/uniprot/H8W6C3 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/1163748:MARHY_RS06560 ^@ http://purl.uniprot.org/uniprot/H8WB56 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NqrA family.|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. http://togogenome.org/gene/1163748:MARHY_RS02550 ^@ http://purl.uniprot.org/uniprot/H8WEH4 ^@ Function|||Similarity ^@ Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).|||In the C-terminal section; belongs to the transpeptidase family.|||In the N-terminal section; belongs to the glycosyltransferase 51 family. http://togogenome.org/gene/1163748:MARHY_RS03785 ^@ http://purl.uniprot.org/uniprot/H8W658 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS06455 ^@ http://purl.uniprot.org/uniprot/H8WB34 ^@ Function|||Similarity ^@ Belongs to the CcmH/CycL/Ccl2/NrfF family.|||Possible subunit of a heme lyase. http://togogenome.org/gene/1163748:MARHY_RS11450 ^@ http://purl.uniprot.org/uniprot/H8W957 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||In the N-terminal section; belongs to the FGAMS family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. http://togogenome.org/gene/1163748:MARHY_RS03675 ^@ http://purl.uniprot.org/uniprot/H8W5M4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.|||Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS18225 ^@ http://purl.uniprot.org/uniprot/H8WA65 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/1163748:MARHY_RS08020 ^@ http://purl.uniprot.org/uniprot/H8WDU9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DnaX/STICHEL family.|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/1163748:MARHY_RS09570 ^@ http://purl.uniprot.org/uniprot/H8W5S3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic sulfate-binding protein family.|||Periplasm http://togogenome.org/gene/1163748:MARHY_RS03860 ^@ http://purl.uniprot.org/uniprot/H8W673 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/1163748:MARHY_RS06085 ^@ http://purl.uniprot.org/uniprot/H8WAE0 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/1163748:MARHY_RS13400 ^@ http://purl.uniprot.org/uniprot/H8WCQ7 ^@ Similarity ^@ Belongs to the elongation factor P family. http://togogenome.org/gene/1163748:MARHY_RS10520 ^@ http://purl.uniprot.org/uniprot/H8W788 ^@ Similarity ^@ Belongs to the aspartate/glutamate racemases family. http://togogenome.org/gene/1163748:MARHY_RS13845 ^@ http://purl.uniprot.org/uniprot/H8WDG1 ^@ Similarity ^@ Belongs to the LOG family. http://togogenome.org/gene/1163748:MARHY_RS08045 ^@ http://purl.uniprot.org/uniprot/H8WDV4 ^@ Similarity ^@ Belongs to the UPF0260 family. http://togogenome.org/gene/1163748:MARHY_RS07175 ^@ http://purl.uniprot.org/uniprot/H8WBZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS03500 ^@ http://purl.uniprot.org/uniprot/H8W5J0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate 5-kinase family.|||Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS11265 ^@ http://purl.uniprot.org/uniprot/H8W8L4 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS12865 ^@ http://purl.uniprot.org/uniprot/H8WBH3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/1163748:MARHY_RS11730 ^@ http://purl.uniprot.org/uniprot/H8W9S2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transferase hexapeptide repeat family. LpxA subfamily.|||Cytoplasm|||Homotrimer.|||Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. http://togogenome.org/gene/1163748:MARHY_RS09915 ^@ http://purl.uniprot.org/uniprot/H8W6F3 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS02980 ^@ http://purl.uniprot.org/uniprot/H8W4S4 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/1163748:MARHY_RS10355 ^@ http://purl.uniprot.org/uniprot/H8W753 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family.|||Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.|||The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod. http://togogenome.org/gene/1163748:MARHY_RS03780 ^@ http://purl.uniprot.org/uniprot/H8W657 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurF subfamily.|||Cytoplasm|||Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. http://togogenome.org/gene/1163748:MARHY_RS06145 ^@ http://purl.uniprot.org/uniprot/H8WAE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Cell membrane|||Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).|||Membrane http://togogenome.org/gene/1163748:MARHY_RS04645 ^@ http://purl.uniprot.org/uniprot/H8W7K3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS07390 ^@ http://purl.uniprot.org/uniprot/H8WCJ7 ^@ Function|||Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate. http://togogenome.org/gene/1163748:MARHY_RS11030 ^@ http://purl.uniprot.org/uniprot/H8W8G5 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/1163748:MARHY_RS07220 ^@ http://purl.uniprot.org/uniprot/H8WCG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OmpP1/FadL family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS05750 ^@ http://purl.uniprot.org/uniprot/H8W9L3 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. http://togogenome.org/gene/1163748:MARHY_RS04125 ^@ http://purl.uniprot.org/uniprot/H8W6T6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family.|||Binds 1 Mg(2+) ion per monomer.|||Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. http://togogenome.org/gene/1163748:MARHY_RS09685 ^@ http://purl.uniprot.org/uniprot/H8W5U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS05140 ^@ http://purl.uniprot.org/uniprot/H8W8B8 ^@ Similarity ^@ Belongs to the VgrG protein family. http://togogenome.org/gene/1163748:MARHY_RS14630 ^@ http://purl.uniprot.org/uniprot/H8WEU4 ^@ Similarity|||Subunit ^@ Belongs to the Ahb/Nir family.|||Probably forms a complex composed of NirD, NirL, NirG and NirH. All proteins are required for the total conversion of siroheme to didecarboxysiroheme. http://togogenome.org/gene/1163748:MARHY_RS04630 ^@ http://purl.uniprot.org/uniprot/H8W7J8 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/1163748:MARHY_RS16565 ^@ http://purl.uniprot.org/uniprot/H8W7C9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/1163748:MARHY_RS01455 ^@ http://purl.uniprot.org/uniprot/H8WCX6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.|||Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD). http://togogenome.org/gene/1163748:MARHY_RS16025 ^@ http://purl.uniprot.org/uniprot/H8W6L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS03890 ^@ http://purl.uniprot.org/uniprot/H8W679 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS04430 ^@ http://purl.uniprot.org/uniprot/H8W6Z7 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/1163748:MARHY_RS16575 ^@ http://purl.uniprot.org/uniprot/H8W7D1 ^@ Function|||PTM|||Similarity ^@ An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.|||Belongs to the polyphosphate kinase 1 (PPK1) family.|||Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). http://togogenome.org/gene/1163748:MARHY_RS18150 ^@ http://purl.uniprot.org/uniprot/H8WA49 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS08100 ^@ http://purl.uniprot.org/uniprot/H8WDW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS05185 ^@ http://purl.uniprot.org/uniprot/H8W8C7 ^@ Similarity ^@ Belongs to the proline racemase family. http://togogenome.org/gene/1163748:MARHY_RS05675 ^@ http://purl.uniprot.org/uniprot/H8W9J8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS04710 ^@ http://purl.uniprot.org/uniprot/H8W7L7 ^@ Function|||Similarity ^@ Belongs to the RecO family.|||Involved in DNA repair and RecF pathway recombination. http://togogenome.org/gene/1163748:MARHY_RS14010 ^@ http://purl.uniprot.org/uniprot/H8WDJ8 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS15320 ^@ http://purl.uniprot.org/uniprot/H8W590 ^@ Similarity ^@ Belongs to the UPF0125 (RnfH) family. http://togogenome.org/gene/1163748:MARHY_RS07660 ^@ http://purl.uniprot.org/uniprot/H8WD64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CpoB family.|||Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.|||Periplasm http://togogenome.org/gene/1163748:MARHY_RS16990 ^@ http://purl.uniprot.org/uniprot/H8W829 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/1163748:MARHY_RS16340 ^@ http://purl.uniprot.org/uniprot/H8W6S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS14295 ^@ http://purl.uniprot.org/uniprot/H8WE68 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS16520 ^@ http://purl.uniprot.org/uniprot/H8W7B8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/1163748:MARHY_RS08860 ^@ http://purl.uniprot.org/uniprot/H8W4D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS12860 ^@ http://purl.uniprot.org/uniprot/H8WBH2 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS16225 ^@ http://purl.uniprot.org/uniprot/H8W6Q0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/1163748:MARHY_RS14985 ^@ http://purl.uniprot.org/uniprot/H8W4L2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Bcr/CmlA family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS12360 ^@ http://purl.uniprot.org/uniprot/H8WAQ3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MlaE permease family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.|||The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD). http://togogenome.org/gene/1163748:MARHY_RS18210 ^@ http://purl.uniprot.org/uniprot/H8WA62 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS10205 ^@ http://purl.uniprot.org/uniprot/H8W723 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/1163748:MARHY_RS05920 ^@ http://purl.uniprot.org/uniprot/H8W9Q1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial histone-like protein family.|||Heterodimer of an alpha and a beta chain.|||This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. http://togogenome.org/gene/1163748:MARHY_RS04895 ^@ http://purl.uniprot.org/uniprot/H8W865 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1163748:MARHY_RS13310 ^@ http://purl.uniprot.org/uniprot/H8WCN6 ^@ Similarity ^@ Belongs to the 2-oxoadipate dioxygenase/decarboxylase family. http://togogenome.org/gene/1163748:MARHY_RS07420 ^@ http://purl.uniprot.org/uniprot/H8WCK3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ClpS family.|||Binds to the N-terminal domain of the chaperone ClpA.|||Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation. http://togogenome.org/gene/1163748:MARHY_RS02930 ^@ http://purl.uniprot.org/uniprot/H8W4A3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/1163748:MARHY_RS08775 ^@ http://purl.uniprot.org/uniprot/H8W4B5 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/1163748:MARHY_RS04615 ^@ http://purl.uniprot.org/uniprot/H8W7J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS00680 ^@ http://purl.uniprot.org/uniprot/H8WBJ6 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/1163748:MARHY_RS14755 ^@ http://purl.uniprot.org/uniprot/H8WEW9 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/1163748:MARHY_RS05525 ^@ http://purl.uniprot.org/uniprot/H8W911 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS12665 ^@ http://purl.uniprot.org/uniprot/H8WBD3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.|||Cytoplasm|||Heteromultimer composed of HisG and HisZ subunits.|||Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.|||This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one. http://togogenome.org/gene/1163748:MARHY_RS05495 ^@ http://purl.uniprot.org/uniprot/H8W905 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAD-like hydrolase superfamily. PhnX family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Involved in phosphonate degradation. http://togogenome.org/gene/1163748:MARHY_RS01195 ^@ http://purl.uniprot.org/uniprot/H8WCB2 ^@ Function ^@ Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. http://togogenome.org/gene/1163748:MARHY_RS08400 ^@ http://purl.uniprot.org/uniprot/H8WEI8 ^@ Similarity ^@ Belongs to the transglycosylase Slt family. http://togogenome.org/gene/1163748:MARHY_RS12640 ^@ http://purl.uniprot.org/uniprot/H8WBC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response.|||Belongs to the SrkA/RdoA protein kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS12030 ^@ http://purl.uniprot.org/uniprot/H8W9Y3 ^@ Cofactor ^@ Binds 2 Mg(2+) ions per monomer. http://togogenome.org/gene/1163748:MARHY_RS02820 ^@ http://purl.uniprot.org/uniprot/H8W479 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/1163748:MARHY_RS16815 ^@ http://purl.uniprot.org/uniprot/H8W7Z3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/1163748:MARHY_RS04225 ^@ http://purl.uniprot.org/uniprot/H8W6V6 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/1163748:MARHY_RS04975 ^@ http://purl.uniprot.org/uniprot/H8W882 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS16755 ^@ http://purl.uniprot.org/uniprot/H8W7H1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.|||Cell membrane|||Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane|||Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function. http://togogenome.org/gene/1163748:MARHY_RS03920 ^@ http://purl.uniprot.org/uniprot/H8W685 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the haloalkane dehalogenase family. Type 1 subfamily.|||Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS07965 ^@ http://purl.uniprot.org/uniprot/H8WDT8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS05210 ^@ http://purl.uniprot.org/uniprot/H8W8D2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.|||Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD). http://togogenome.org/gene/1163748:MARHY_RS02445 ^@ http://purl.uniprot.org/uniprot/A0A8B0N6E7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoD/SigA subfamily.|||Cytoplasm|||Interacts transiently with the RNA polymerase catalytic core.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. http://togogenome.org/gene/1163748:MARHY_RS00940 ^@ http://purl.uniprot.org/uniprot/H8WBQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NlpA lipoprotein family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS14810 ^@ http://purl.uniprot.org/uniprot/H8WEY0 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/1163748:MARHY_RS05570 ^@ http://purl.uniprot.org/uniprot/H8W920 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS18230 ^@ http://purl.uniprot.org/uniprot/H8WA66 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase gamma chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. http://togogenome.org/gene/1163748:MARHY_RS03330 ^@ http://purl.uniprot.org/uniprot/H8W5F7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.|||Binds 1 zinc ion per subunit.|||Binds the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1163748:MARHY_RS15640 ^@ http://purl.uniprot.org/uniprot/H8W5W8 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily. http://togogenome.org/gene/1163748:MARHY_RS16000 ^@ http://purl.uniprot.org/uniprot/H8W6K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.|||Cell inner membrane http://togogenome.org/gene/1163748:MARHY_RS18455 ^@ http://purl.uniprot.org/uniprot/H8W497 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/1163748:MARHY_RS16700 ^@ http://purl.uniprot.org/uniprot/H8W7F8 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/1163748:MARHY_RS01750 ^@ http://purl.uniprot.org/uniprot/H8WD34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS04510 ^@ http://purl.uniprot.org/uniprot/H8W7H3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/1163748:MARHY_RS00100 ^@ http://purl.uniprot.org/uniprot/H8WA99 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS16640 ^@ http://purl.uniprot.org/uniprot/H8W7E5 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/1163748:MARHY_RS09560 ^@ http://purl.uniprot.org/uniprot/H8W5S1 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS05490 ^@ http://purl.uniprot.org/uniprot/H8W904 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.|||Homodimer.|||Involved in phosphonate degradation. http://togogenome.org/gene/1163748:MARHY_RS06295 ^@ http://purl.uniprot.org/uniprot/H8WAI0 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliO/MopB family.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS08305 ^@ http://purl.uniprot.org/uniprot/H8WE08 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccD/PCCB family.|||Binds 1 zinc ion per subunit.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS01820 ^@ http://purl.uniprot.org/uniprot/H8WDK7 ^@ Similarity ^@ Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. http://togogenome.org/gene/1163748:MARHY_RS10105 ^@ http://purl.uniprot.org/uniprot/H8W6J3 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/1163748:MARHY_RS03410 ^@ http://purl.uniprot.org/uniprot/H8W5H3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.|||Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.|||Cytoplasm|||Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).|||The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.|||The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1. http://togogenome.org/gene/1163748:MARHY_RS17220 ^@ http://purl.uniprot.org/uniprot/H8W8N5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS11925 ^@ http://purl.uniprot.org/uniprot/H8W9W1 ^@ Similarity ^@ Belongs to the UPF0234 family. http://togogenome.org/gene/1163748:MARHY_RS06150 ^@ http://purl.uniprot.org/uniprot/H8WAE9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS13135 ^@ http://purl.uniprot.org/uniprot/H8WC38 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS10745 ^@ http://purl.uniprot.org/uniprot/H8W7U6 ^@ PTM|||Similarity|||Subunit ^@ Belongs to the gamma-glutamyltransferase family.|||Cleaved by autocatalysis into a large and a small subunit.|||This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide. http://togogenome.org/gene/1163748:MARHY_RS10320 ^@ http://purl.uniprot.org/uniprot/H8W745 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.|||Bacterial flagellum basal body|||Belongs to the FlgI family.|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. http://togogenome.org/gene/1163748:MARHY_RS04715 ^@ http://purl.uniprot.org/uniprot/H8W7L8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP synthase family.|||Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.|||Cytoplasm|||Homooctamer; tetramer of dimers. http://togogenome.org/gene/1163748:MARHY_RS08255 ^@ http://purl.uniprot.org/uniprot/H8WDZ6 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS10670 ^@ http://purl.uniprot.org/uniprot/H8W7T0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/1163748:MARHY_RS14830 ^@ http://purl.uniprot.org/uniprot/H8WEY4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the BPG-independent phosphoglycerate mutase family.|||Binds 2 manganese ions per subunit.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS00520 ^@ http://purl.uniprot.org/uniprot/H8WB05 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS04365 ^@ http://purl.uniprot.org/uniprot/H8W6Y4 ^@ Function|||Similarity ^@ Belongs to the MinE family.|||Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. http://togogenome.org/gene/1163748:MARHY_RS02810 ^@ http://purl.uniprot.org/uniprot/H8W477 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/1163748:MARHY_RS05605 ^@ http://purl.uniprot.org/uniprot/H8W927 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS14960 ^@ http://purl.uniprot.org/uniprot/H8W4K7 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS15515 ^@ http://purl.uniprot.org/uniprot/H8W5D6 ^@ Function|||Similarity ^@ Belongs to the PqqC family.|||Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ. http://togogenome.org/gene/1163748:MARHY_RS13935 ^@ http://purl.uniprot.org/uniprot/H8WDI0 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/1163748:MARHY_RS06810 ^@ http://purl.uniprot.org/uniprot/H8WBR7 ^@ Similarity ^@ Belongs to the YciI family. http://togogenome.org/gene/1163748:MARHY_RS04865 ^@ http://purl.uniprot.org/uniprot/H8W7P9 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1163748:MARHY_RS09755 ^@ http://purl.uniprot.org/uniprot/H8W5W0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS14905 ^@ http://purl.uniprot.org/uniprot/H8W4J6 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/1163748:MARHY_RS04325 ^@ http://purl.uniprot.org/uniprot/H8W6X6 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/1163748:MARHY_RS15820 ^@ http://purl.uniprot.org/uniprot/H8W605 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose 5-phosphate isomerase family.|||Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS09625 ^@ http://purl.uniprot.org/uniprot/H8W5T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS01210 ^@ http://purl.uniprot.org/uniprot/H8WCB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS15280 ^@ http://purl.uniprot.org/uniprot/H8W582 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/1163748:MARHY_RS11750 ^@ http://purl.uniprot.org/uniprot/H8W9S6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BamA family.|||Cell outer membrane|||Part of the Bam complex.|||Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. http://togogenome.org/gene/1163748:MARHY_RS13140 ^@ http://purl.uniprot.org/uniprot/H8WC39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.|||Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS07015 ^@ http://purl.uniprot.org/uniprot/H8WBV5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/1163748:MARHY_RS17210 ^@ http://purl.uniprot.org/uniprot/H8W8N3 ^@ Similarity ^@ Belongs to the PspA/IM30 family. http://togogenome.org/gene/1163748:MARHY_RS11510 ^@ http://purl.uniprot.org/uniprot/H8W969 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. http://togogenome.org/gene/1163748:MARHY_RS03230 ^@ http://purl.uniprot.org/uniprot/H8W4X5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS06355 ^@ http://purl.uniprot.org/uniprot/H8WAJ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CheZ family.|||Cytoplasm|||Homodimer.|||Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P). http://togogenome.org/gene/1163748:MARHY_RS12055 ^@ http://purl.uniprot.org/uniprot/H8W9Y9 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS06320 ^@ http://purl.uniprot.org/uniprot/H8WAI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS11505 ^@ http://purl.uniprot.org/uniprot/H8W968 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. UbiG/COQ3 family.|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/1163748:MARHY_RS11365 ^@ http://purl.uniprot.org/uniprot/H8W946 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS05905 ^@ http://purl.uniprot.org/uniprot/H8W9P8 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/1163748:MARHY_RS00185 ^@ http://purl.uniprot.org/uniprot/H8WAB5 ^@ Similarity ^@ Belongs to the MotB family. http://togogenome.org/gene/1163748:MARHY_RS15760 ^@ http://purl.uniprot.org/uniprot/H8W5Z2 ^@ Similarity ^@ Belongs to the UbiH/COQ6 family. http://togogenome.org/gene/1163748:MARHY_RS15655 ^@ http://purl.uniprot.org/uniprot/H8W5X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS02640 ^@ http://purl.uniprot.org/uniprot/H8W448 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS13070 ^@ http://purl.uniprot.org/uniprot/H8WC24 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/1163748:MARHY_RS08270 ^@ http://purl.uniprot.org/uniprot/H8WE00 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS15155 ^@ http://purl.uniprot.org/uniprot/H8W4P6 ^@ Similarity ^@ Belongs to the leucine-binding protein family. http://togogenome.org/gene/1163748:MARHY_RS02900 ^@ http://purl.uniprot.org/uniprot/H8W496 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/1163748:MARHY_RS03425 ^@ http://purl.uniprot.org/uniprot/H8W5H6 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion.|||Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.|||In the C-terminal section; belongs to the HTP reductase family.|||In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/1163748:MARHY_RS07505 ^@ http://purl.uniprot.org/uniprot/H8WCM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS16855 ^@ http://purl.uniprot.org/uniprot/H8W801 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0014 family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS04005 ^@ http://purl.uniprot.org/uniprot/H8W6A2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RlpA family.|||Cell membrane|||Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. http://togogenome.org/gene/1163748:MARHY_RS13670 ^@ http://purl.uniprot.org/uniprot/H8WDC4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial microcompartment|||Belongs to the EutC family.|||Binds between the large and small subunits.|||Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.|||The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards. http://togogenome.org/gene/1163748:MARHY_RS16800 ^@ http://purl.uniprot.org/uniprot/H8W7Z0 ^@ Similarity ^@ Belongs to the UbiH/COQ6 family. http://togogenome.org/gene/1163748:MARHY_RS09350 ^@ http://purl.uniprot.org/uniprot/H8W566 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/1163748:MARHY_RS00605 ^@ http://purl.uniprot.org/uniprot/H8WB21 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/1163748:MARHY_RS03980 ^@ http://purl.uniprot.org/uniprot/H8W697 ^@ Function|||Similarity ^@ Belongs to the NadD family.|||Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). http://togogenome.org/gene/1163748:MARHY_RS10040 ^@ http://purl.uniprot.org/uniprot/H8W6H9 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/1163748:MARHY_RS03935 ^@ http://purl.uniprot.org/uniprot/H8W688 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS02800 ^@ http://purl.uniprot.org/uniprot/H8W475 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||Methylated by PrmB.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/1163748:MARHY_RS13975 ^@ http://purl.uniprot.org/uniprot/H8WDJ0 ^@ Cofactor|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.|||Binds 2 nickel ions per subunit.|||Carbamylation allows a single lysine to coordinate two nickel ions.|||Carboxylation allows a single lysine to coordinate two nickel ions.|||Cytoplasm|||Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. http://togogenome.org/gene/1163748:MARHY_RS03805 ^@ http://purl.uniprot.org/uniprot/H8W662 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS06920 ^@ http://purl.uniprot.org/uniprot/H8WBU0 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS03830 ^@ http://purl.uniprot.org/uniprot/H8W667 ^@ Function|||Similarity ^@ Belongs to the LpxC family.|||Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. http://togogenome.org/gene/1163748:MARHY_RS16205 ^@ http://purl.uniprot.org/uniprot/H8W6P6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ThiG family.|||Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.|||Cytoplasm|||Homotetramer. Forms heterodimers with either ThiH or ThiS. http://togogenome.org/gene/1163748:MARHY_RS11555 ^@ http://purl.uniprot.org/uniprot/H8W978 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS06590 ^@ http://purl.uniprot.org/uniprot/H8WB62 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ApbE family.|||Cell inner membrane|||Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.|||Magnesium. Can also use manganese. http://togogenome.org/gene/1163748:MARHY_RS09370 ^@ http://purl.uniprot.org/uniprot/H8W571 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS10195 ^@ http://purl.uniprot.org/uniprot/H8W721 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/1163748:MARHY_RS12650 ^@ http://purl.uniprot.org/uniprot/H8WBD0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.|||Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS00095 ^@ http://purl.uniprot.org/uniprot/H8WA98 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS03765 ^@ http://purl.uniprot.org/uniprot/H8W654 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsL family.|||Cell inner membrane|||Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.|||Membrane|||Part of a complex composed of FtsB, FtsL and FtsQ. http://togogenome.org/gene/1163748:MARHY_RS03270 ^@ http://purl.uniprot.org/uniprot/H8W4Y3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/1163748:MARHY_RS12195 ^@ http://purl.uniprot.org/uniprot/H8WAM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol monophosphatase superfamily. CysQ family.|||Cell inner membrane|||Converts adenosine-3',5'-bisphosphate (PAP) to AMP. http://togogenome.org/gene/1163748:MARHY_RS11160 ^@ http://purl.uniprot.org/uniprot/H8W8J3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer.|||In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.|||In the N-terminal section; belongs to the MIP18 family. http://togogenome.org/gene/1163748:MARHY_RS06965 ^@ http://purl.uniprot.org/uniprot/H8WBU9 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/1163748:MARHY_RS09250 ^@ http://purl.uniprot.org/uniprot/H8W543 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS09280 ^@ http://purl.uniprot.org/uniprot/H8W549 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS16965 ^@ http://purl.uniprot.org/uniprot/H8W824 ^@ Subcellular Location Annotation ^@ Cell outer membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS06360 ^@ http://purl.uniprot.org/uniprot/H8WAJ3 ^@ Function ^@ Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY. http://togogenome.org/gene/1163748:MARHY_RS07940 ^@ http://purl.uniprot.org/uniprot/H8WDC1 ^@ Similarity ^@ Belongs to the asparagine synthetase family. http://togogenome.org/gene/1163748:MARHY_RS11035 ^@ http://purl.uniprot.org/uniprot/H8W8G6 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS03260 ^@ http://purl.uniprot.org/uniprot/H8W4Y1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the vitamin-B12 independent methionine synthase family.|||Binds 1 zinc ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation. http://togogenome.org/gene/1163748:MARHY_RS14840 ^@ http://purl.uniprot.org/uniprot/H8WEY6 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/1163748:MARHY_RS09400 ^@ http://purl.uniprot.org/uniprot/H8W5N5 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS12370 ^@ http://purl.uniprot.org/uniprot/H8WAQ5 ^@ Similarity ^@ Belongs to the SIS family. GutQ/KpsF subfamily. http://togogenome.org/gene/1163748:MARHY_RS09865 ^@ http://purl.uniprot.org/uniprot/H8W6E2 ^@ PTM ^@ Binds 2 heme c groups covalently per subunit. http://togogenome.org/gene/1163748:MARHY_RS02235 ^@ http://purl.uniprot.org/uniprot/H8WEA5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS14570 ^@ http://purl.uniprot.org/uniprot/H8WET2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS01070 ^@ http://purl.uniprot.org/uniprot/H8WC86 ^@ Function|||Similarity ^@ Belongs to the CobB/CobQ family. CobQ subfamily.|||Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. http://togogenome.org/gene/1163748:MARHY_RS13380 ^@ http://purl.uniprot.org/uniprot/H8WCQ2 ^@ Similarity ^@ Belongs to the transglycosylase Slt family. http://togogenome.org/gene/1163748:MARHY_RS15230 ^@ http://purl.uniprot.org/uniprot/H8W4R1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RimP family.|||Cytoplasm|||Required for maturation of 30S ribosomal subunits. http://togogenome.org/gene/1163748:MARHY_RS02605 ^@ http://purl.uniprot.org/uniprot/H8W441 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS15720 ^@ http://purl.uniprot.org/uniprot/H8W5Y4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRA-CH family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS14585 ^@ http://purl.uniprot.org/uniprot/H8WET5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS00050 ^@ http://purl.uniprot.org/uniprot/H8WA89 ^@ Function|||Similarity|||Subunit ^@ A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.|||Belongs to the RecD family.|||Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. http://togogenome.org/gene/1163748:MARHY_RS10415 ^@ http://purl.uniprot.org/uniprot/H8W765 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS06285 ^@ http://purl.uniprot.org/uniprot/H8WAH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliM family.|||Cell inner membrane|||FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS01590 ^@ http://purl.uniprot.org/uniprot/H8WD03 ^@ Function ^@ The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. http://togogenome.org/gene/1163748:MARHY_RS11525 ^@ http://purl.uniprot.org/uniprot/H8W972 ^@ Similarity ^@ Belongs to the UPF0246 family. http://togogenome.org/gene/1163748:MARHY_RS11825 ^@ http://purl.uniprot.org/uniprot/H8W9U1 ^@ Similarity ^@ Belongs to the SlyX family. http://togogenome.org/gene/1163748:MARHY_RS05885 ^@ http://purl.uniprot.org/uniprot/H8W9P2 ^@ Function|||Subcellular Location Annotation ^@ Cell inner membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system. http://togogenome.org/gene/1163748:MARHY_RS03530 ^@ http://purl.uniprot.org/uniprot/H8W5J7 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/1163748:MARHY_RS10295 ^@ http://purl.uniprot.org/uniprot/H8W741 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueA family.|||Cytoplasm|||Monomer.|||Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). http://togogenome.org/gene/1163748:MARHY_RS16510 ^@ http://purl.uniprot.org/uniprot/H8W7B6 ^@ Similarity ^@ Belongs to the UPF0758 family. http://togogenome.org/gene/1163748:MARHY_RS06045 ^@ http://purl.uniprot.org/uniprot/H8WAD2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/1163748:MARHY_RS10740 ^@ http://purl.uniprot.org/uniprot/H8W7U5 ^@ Function|||Similarity ^@ Belongs to the PurU family.|||Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). http://togogenome.org/gene/1163748:MARHY_RS16645 ^@ http://purl.uniprot.org/uniprot/H8W7E6 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase family. http://togogenome.org/gene/1163748:MARHY_RS05665 ^@ http://purl.uniprot.org/uniprot/H8W9J6 ^@ Cofactor ^@ Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/1163748:MARHY_RS00635 ^@ http://purl.uniprot.org/uniprot/H8WBI7 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS06550 ^@ http://purl.uniprot.org/uniprot/H8WB54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.|||Cytoplasm|||In the C-terminal section; belongs to the helicase family. RecG subfamily.|||In the N-terminal section; belongs to the UvrB family. http://togogenome.org/gene/1163748:MARHY_RS09905 ^@ http://purl.uniprot.org/uniprot/H8W6F1 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/1163748:MARHY_RS06315 ^@ http://purl.uniprot.org/uniprot/H8WAI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type III secretion exporter family.|||Cell membrane|||Membrane|||Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin. http://togogenome.org/gene/1163748:MARHY_RS04155 ^@ http://purl.uniprot.org/uniprot/H8W6U3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS03405 ^@ http://purl.uniprot.org/uniprot/H8W5H2 ^@ Domain|||Function|||Similarity ^@ Belongs to the RecA family. RadA subfamily.|||DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.|||Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.|||The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. http://togogenome.org/gene/1163748:MARHY_RS14690 ^@ http://purl.uniprot.org/uniprot/H8WEV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS01330 ^@ http://purl.uniprot.org/uniprot/H8WCD9 ^@ Similarity ^@ Belongs to the mandelate racemase/muconate lactonizing enzyme family. http://togogenome.org/gene/1163748:MARHY_RS12470 ^@ http://purl.uniprot.org/uniprot/H8WAS4 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/1163748:MARHY_RS06830 ^@ http://purl.uniprot.org/uniprot/H8WBS2 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/1163748:MARHY_RS04470 ^@ http://purl.uniprot.org/uniprot/H8W705 ^@ Similarity ^@ Belongs to the glutaredoxin family. Monothiol subfamily. http://togogenome.org/gene/1163748:MARHY_RS01435 ^@ http://purl.uniprot.org/uniprot/H8WCX2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS01640 ^@ http://purl.uniprot.org/uniprot/H8WD12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HupC/HyaC/HydC family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS18275 ^@ http://purl.uniprot.org/uniprot/H8WA75 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. http://togogenome.org/gene/1163748:MARHY_RS16135 ^@ http://purl.uniprot.org/uniprot/H8W6N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS14430 ^@ http://purl.uniprot.org/uniprot/H8WE95 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS12240 ^@ http://purl.uniprot.org/uniprot/H8WAM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CoaE family.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS09535 ^@ http://purl.uniprot.org/uniprot/H8W5R5 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS09735 ^@ http://purl.uniprot.org/uniprot/H8W5V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS15300 ^@ http://purl.uniprot.org/uniprot/H8W586 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/1163748:MARHY_RS13620 ^@ http://purl.uniprot.org/uniprot/H8WCV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 51 family.|||Cell inner membrane|||Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors. http://togogenome.org/gene/1163748:MARHY_RS09985 ^@ http://purl.uniprot.org/uniprot/H8W6G8 ^@ Function|||Similarity ^@ Belongs to the FlgN family.|||Required for the efficient initiation of filament assembly. http://togogenome.org/gene/1163748:MARHY_RS06365 ^@ http://purl.uniprot.org/uniprot/H8WAJ4 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CheB family.|||Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.|||Cytoplasm|||Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.|||Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity. http://togogenome.org/gene/1163748:MARHY_RS03450 ^@ http://purl.uniprot.org/uniprot/H8W5I1 ^@ Function|||Subcellular Location Annotation ^@ Cell inner membrane|||Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). http://togogenome.org/gene/1163748:MARHY_RS04015 ^@ http://purl.uniprot.org/uniprot/H8W6A4 ^@ Similarity ^@ Belongs to the UPF0250 family. http://togogenome.org/gene/1163748:MARHY_RS09960 ^@ http://purl.uniprot.org/uniprot/H8W6G3 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS15890 ^@ http://purl.uniprot.org/uniprot/H8W621 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/1163748:MARHY_RS01515 ^@ http://purl.uniprot.org/uniprot/H8WCY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter small permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/1163748:MARHY_RS14195 ^@ http://purl.uniprot.org/uniprot/H8WE48 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS07190 ^@ http://purl.uniprot.org/uniprot/H8WCF5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS04110 ^@ http://purl.uniprot.org/uniprot/H8W6C4 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. http://togogenome.org/gene/1163748:MARHY_RS04150 ^@ http://purl.uniprot.org/uniprot/H8W6U2 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/1163748:MARHY_RS07065 ^@ http://purl.uniprot.org/uniprot/H8WBW7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IlvD/Edd family.|||Binds 1 [4Fe-4S] cluster.|||Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate. http://togogenome.org/gene/1163748:MARHY_RS12735 ^@ http://purl.uniprot.org/uniprot/H8WBE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS15810 ^@ http://purl.uniprot.org/uniprot/H8W602 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/1163748:MARHY_RS03915 ^@ http://purl.uniprot.org/uniprot/H8W684 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/1163748:MARHY_RS06895 ^@ http://purl.uniprot.org/uniprot/H8WBT5 ^@ Function|||Similarity ^@ Belongs to the thymidylate kinase family.|||Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. http://togogenome.org/gene/1163748:MARHY_RS02585 ^@ http://purl.uniprot.org/uniprot/H8W437 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS02110 ^@ http://purl.uniprot.org/uniprot/H8WDR7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.|||Homodimer or homotetramer. http://togogenome.org/gene/1163748:MARHY_RS01305 ^@ http://purl.uniprot.org/uniprot/H8WCD4 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/1163748:MARHY_RS05255 ^@ http://purl.uniprot.org/uniprot/H8W8E2 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/1163748:MARHY_RS15035 ^@ http://purl.uniprot.org/uniprot/H8W4M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS05705 ^@ http://purl.uniprot.org/uniprot/H8W9K4 ^@ Similarity ^@ In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1163748:MARHY_RS11165 ^@ http://purl.uniprot.org/uniprot/H8W8J4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. http://togogenome.org/gene/1163748:MARHY_RS15305 ^@ http://purl.uniprot.org/uniprot/H8W587 ^@ Function|||Similarity ^@ Belongs to the RecN family.|||May be involved in recombinational repair of damaged DNA. http://togogenome.org/gene/1163748:MARHY_RS06000 ^@ http://purl.uniprot.org/uniprot/H8W9R7 ^@ Function|||Similarity ^@ Belongs to the RmuC family.|||Involved in DNA recombination. http://togogenome.org/gene/1163748:MARHY_RS16270 ^@ http://purl.uniprot.org/uniprot/H8W6R0 ^@ Function|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.|||Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. http://togogenome.org/gene/1163748:MARHY_RS09740 ^@ http://purl.uniprot.org/uniprot/H8W5V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS04500 ^@ http://purl.uniprot.org/uniprot/H8W712 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/1163748:MARHY_RS15295 ^@ http://purl.uniprot.org/uniprot/H8W585 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/1163748:MARHY_RS08420 ^@ http://purl.uniprot.org/uniprot/H8WEJ3 ^@ Function|||Subunit ^@ DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease. http://togogenome.org/gene/1163748:MARHY_RS12335 ^@ http://purl.uniprot.org/uniprot/H8WAP8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS08300 ^@ http://purl.uniprot.org/uniprot/H8WE07 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/1163748:MARHY_RS15850 ^@ http://purl.uniprot.org/uniprot/H8W613 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type-II 3-dehydroquinase family.|||Catalyzes a trans-dehydration via an enolate intermediate.|||Homododecamer. http://togogenome.org/gene/1163748:MARHY_RS14860 ^@ http://purl.uniprot.org/uniprot/H8W4I8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/1163748:MARHY_RS10120 ^@ http://purl.uniprot.org/uniprot/H8W6J6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/1163748:MARHY_RS10675 ^@ http://purl.uniprot.org/uniprot/H8W7T1 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1163748:MARHY_RS11240 ^@ http://purl.uniprot.org/uniprot/H8W8K9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IspF family.|||Binds 1 divalent metal cation per subunit.|||Homotrimer.|||Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS08455 ^@ http://purl.uniprot.org/uniprot/H8WEK1 ^@ Domain|||Function|||Similarity ^@ Belongs to the vitamin-B12 dependent methionine synthase family.|||Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.|||Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin. http://togogenome.org/gene/1163748:MARHY_RS10325 ^@ http://purl.uniprot.org/uniprot/H8W746 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.|||Bacterial flagellum basal body|||Belongs to the FlgH family.|||Cell outer membrane|||Membrane|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. http://togogenome.org/gene/1163748:MARHY_RS07245 ^@ http://purl.uniprot.org/uniprot/H8WCG6 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TtcA family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.|||Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.|||Cytoplasm|||Homodimer.|||The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster. http://togogenome.org/gene/1163748:MARHY_RS08290 ^@ http://purl.uniprot.org/uniprot/H8WE05 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/1163748:MARHY_RS06865 ^@ http://purl.uniprot.org/uniprot/H8WBS9 ^@ Similarity ^@ Belongs to the fabD family. http://togogenome.org/gene/1163748:MARHY_RS13405 ^@ http://purl.uniprot.org/uniprot/H8WCQ8 ^@ Similarity ^@ Belongs to the acyl coenzyme A hydrolase family. http://togogenome.org/gene/1163748:MARHY_RS08825 ^@ http://purl.uniprot.org/uniprot/H8W4C6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 57 family. http://togogenome.org/gene/1163748:MARHY_RS10025 ^@ http://purl.uniprot.org/uniprot/H8W6H6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/1163748:MARHY_RS06230 ^@ http://purl.uniprot.org/uniprot/H8WAG6 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliE family. http://togogenome.org/gene/1163748:MARHY_RS11230 ^@ http://purl.uniprot.org/uniprot/H8W8K7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/1163748:MARHY_RS15220 ^@ http://purl.uniprot.org/uniprot/H8W4Q9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/1163748:MARHY_RS08180 ^@ http://purl.uniprot.org/uniprot/H8WDY1 ^@ Cofactor ^@ Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/1163748:MARHY_RS06050 ^@ http://purl.uniprot.org/uniprot/H8WAD3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/1163748:MARHY_RS09875 ^@ http://purl.uniprot.org/uniprot/H8W6E5 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/1163748:MARHY_RS18300 ^@ http://purl.uniprot.org/uniprot/H8WAT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS03825 ^@ http://purl.uniprot.org/uniprot/H8W666 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/1163748:MARHY_RS00145 ^@ http://purl.uniprot.org/uniprot/H8WAA7 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/1163748:MARHY_RS11795 ^@ http://purl.uniprot.org/uniprot/H8W9T5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/1163748:MARHY_RS14705 ^@ http://purl.uniprot.org/uniprot/H8WEV9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/1163748:MARHY_RS15960 ^@ http://purl.uniprot.org/uniprot/H8W637 ^@ Cofactor ^@ Can also use Mn(2+) ion. http://togogenome.org/gene/1163748:MARHY_RS04950 ^@ http://purl.uniprot.org/uniprot/H8W877 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS05900 ^@ http://purl.uniprot.org/uniprot/H8W9P6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/1163748:MARHY_RS15685 ^@ http://purl.uniprot.org/uniprot/H8W5X7 ^@ Similarity ^@ Belongs to the long-chain O-acyltransferase family. http://togogenome.org/gene/1163748:MARHY_RS15830 ^@ http://purl.uniprot.org/uniprot/H8W607 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/1163748:MARHY_RS01790 ^@ http://purl.uniprot.org/uniprot/H8WD42 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phospholipase A1 family.|||Binds 1 Ca(2+) ion per monomer. In the dimeric form the Ca(2+) is bound by different amino acids with binding of each Ca(2+) shared with ligands coming from each monomer. The Ca(2+) ion may have a role in catalysis.|||Cell outer membrane|||Homodimer; dimerization is reversible, and the dimeric form is the active one.|||Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS02875 ^@ http://purl.uniprot.org/uniprot/H8W490 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/1163748:MARHY_RS14245 ^@ http://purl.uniprot.org/uniprot/H8WE58 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.|||Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS07840 ^@ http://purl.uniprot.org/uniprot/H8WD99 ^@ Similarity ^@ Belongs to the PrpF family. http://togogenome.org/gene/1163748:MARHY_RS03055 ^@ http://purl.uniprot.org/uniprot/H8W4T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS00125 ^@ http://purl.uniprot.org/uniprot/H8WAA3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1163748:MARHY_RS08550 ^@ http://purl.uniprot.org/uniprot/H8WEM0 ^@ Cofactor|||Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/1163748:MARHY_RS00235 ^@ http://purl.uniprot.org/uniprot/H8WAU3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS18155 ^@ http://purl.uniprot.org/uniprot/H8WA50 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS06805 ^@ http://purl.uniprot.org/uniprot/H8WBR6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS06790 ^@ http://purl.uniprot.org/uniprot/H8WBA1 ^@ Function|||Similarity ^@ Belongs to the PEP-utilizing enzyme family.|||Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. http://togogenome.org/gene/1163748:MARHY_RS06980 ^@ http://purl.uniprot.org/uniprot/H8WBV2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the malate synthase family. GlcB subfamily.|||Cytoplasm|||Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS05195 ^@ http://purl.uniprot.org/uniprot/H8W8C9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS03395 ^@ http://purl.uniprot.org/uniprot/H8W5H0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS05970 ^@ http://purl.uniprot.org/uniprot/H8W9R1 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/1163748:MARHY_RS12900 ^@ http://purl.uniprot.org/uniprot/H8WBI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS02490 ^@ http://purl.uniprot.org/uniprot/H8WEG2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/1163748:MARHY_RS11810 ^@ http://purl.uniprot.org/uniprot/H8W9T8 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/1163748:MARHY_RS08680 ^@ http://purl.uniprot.org/uniprot/H8WEP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 2 family.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS12710 ^@ http://purl.uniprot.org/uniprot/H8WBE2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS01340 ^@ http://purl.uniprot.org/uniprot/H8WCE1 ^@ Similarity ^@ Belongs to the intradiol ring-cleavage dioxygenase family. http://togogenome.org/gene/1163748:MARHY_RS14390 ^@ http://purl.uniprot.org/uniprot/H8WE87 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS09675 ^@ http://purl.uniprot.org/uniprot/H8W5U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP H family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS15800 ^@ http://purl.uniprot.org/uniprot/H8W600 ^@ Function|||Similarity|||Subunit ^@ Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.|||Belongs to the ZapA family. Type 1 subfamily.|||Homodimer. Interacts with FtsZ. http://togogenome.org/gene/1163748:MARHY_RS04770 ^@ http://purl.uniprot.org/uniprot/H8W7M9 ^@ Similarity ^@ Belongs to the KAE1 / TsaD family. TsaB subfamily. http://togogenome.org/gene/1163748:MARHY_RS09710 ^@ http://purl.uniprot.org/uniprot/H8W5V1 ^@ Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS08350 ^@ http://purl.uniprot.org/uniprot/H8WEH8 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1163748:MARHY_RS10715 ^@ http://purl.uniprot.org/uniprot/H8W7U0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS02455 ^@ http://purl.uniprot.org/uniprot/H8WEF5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/1163748:MARHY_RS12475 ^@ http://purl.uniprot.org/uniprot/H8WAS5 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/1163748:MARHY_RS09525 ^@ http://purl.uniprot.org/uniprot/H8W5R3 ^@ Function|||Similarity ^@ Belongs to the BCKDHA family.|||The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/1163748:MARHY_RS13695 ^@ http://purl.uniprot.org/uniprot/H8WDD0 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/1163748:MARHY_RS01490 ^@ http://purl.uniprot.org/uniprot/H8WCY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS15910 ^@ http://purl.uniprot.org/uniprot/H8W626 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1163748:MARHY_RS01585 ^@ http://purl.uniprot.org/uniprot/H8WD02 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNT beta subunit family.|||Cell inner membrane|||Heterodimer of an alpha and a beta chain.|||Membrane|||The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. http://togogenome.org/gene/1163748:MARHY_RS13325 ^@ http://purl.uniprot.org/uniprot/H8WCN9 ^@ Similarity ^@ Belongs to the YkuD family. http://togogenome.org/gene/1163748:MARHY_RS10125 ^@ http://purl.uniprot.org/uniprot/H8W6J8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. Thiolase family.|||Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.|||Cytoplasm|||Heterotetramer of two alpha chains (FadB) and two beta chains (FadA). http://togogenome.org/gene/1163748:MARHY_RS07535 ^@ http://purl.uniprot.org/uniprot/H8WCM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurB family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS18220 ^@ http://purl.uniprot.org/uniprot/H8WA64 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/1163748:MARHY_RS16275 ^@ http://purl.uniprot.org/uniprot/H8W6R1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the anthranilate synthase component I family.|||Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).|||Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. http://togogenome.org/gene/1163748:MARHY_RS04080 ^@ http://purl.uniprot.org/uniprot/H8W6B8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.|||Belongs to the RNR ribonuclease family. RNase R subfamily.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS16120 ^@ http://purl.uniprot.org/uniprot/H8W6M9 ^@ Function|||Similarity ^@ Belongs to the class-I DAHP synthase family.|||Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). http://togogenome.org/gene/1163748:MARHY_RS07260 ^@ http://purl.uniprot.org/uniprot/H8WCG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/1163748:MARHY_RS02855 ^@ http://purl.uniprot.org/uniprot/H8W486 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1163748:MARHY_RS15915 ^@ http://purl.uniprot.org/uniprot/H8W627 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS13970 ^@ http://purl.uniprot.org/uniprot/H8WDI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UreE family.|||Cytoplasm|||Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. http://togogenome.org/gene/1163748:MARHY_RS08240 ^@ http://purl.uniprot.org/uniprot/H8WDZ3 ^@ Function|||Similarity ^@ Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.|||Methylates ribosomal protein uL3 on a specific glutamine residue. http://togogenome.org/gene/1163748:MARHY_RS07610 ^@ http://purl.uniprot.org/uniprot/H8WD54 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1163748:MARHY_RS12300 ^@ http://purl.uniprot.org/uniprot/H8WAP1 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/1163748:MARHY_RS08010 ^@ http://purl.uniprot.org/uniprot/H8WDU7 ^@ Similarity ^@ Belongs to the glucose-6-phosphate 1-epimerase family. http://togogenome.org/gene/1163748:MARHY_RS12390 ^@ http://purl.uniprot.org/uniprot/H8WAQ9 ^@ Function|||Similarity ^@ Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.|||Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system. http://togogenome.org/gene/1163748:MARHY_RS06890 ^@ http://purl.uniprot.org/uniprot/H8WBT4 ^@ Function|||Similarity ^@ Belongs to the transglycosylase MltG family.|||Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. http://togogenome.org/gene/1163748:MARHY_RS11785 ^@ http://purl.uniprot.org/uniprot/H8W9T3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS02740 ^@ http://purl.uniprot.org/uniprot/H8W462 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/1163748:MARHY_RS18075 ^@ http://purl.uniprot.org/uniprot/H8WA34 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS06500 ^@ http://purl.uniprot.org/uniprot/H8WB43 ^@ Function|||Similarity ^@ Belongs to the beta-class carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/1163748:MARHY_RS01875 ^@ http://purl.uniprot.org/uniprot/H8WDL9 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MobA family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.|||Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. http://togogenome.org/gene/1163748:MARHY_RS11600 ^@ http://purl.uniprot.org/uniprot/H8W986 ^@ Similarity ^@ Belongs to the AlaDH/PNT family. http://togogenome.org/gene/1163748:MARHY_RS13075 ^@ http://purl.uniprot.org/uniprot/H8WC25 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS13090 ^@ http://purl.uniprot.org/uniprot/H8WC29 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1163748:MARHY_RS13880 ^@ http://purl.uniprot.org/uniprot/H8WDG8 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/1163748:MARHY_RS16300 ^@ http://purl.uniprot.org/uniprot/H8W6R7 ^@ Similarity ^@ Belongs to the IucA/IucC family. http://togogenome.org/gene/1163748:MARHY_RS16875 ^@ http://purl.uniprot.org/uniprot/H8W805 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS08675 ^@ http://purl.uniprot.org/uniprot/H8WEP6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1163748:MARHY_RS11690 ^@ http://purl.uniprot.org/uniprot/H8W9A4 ^@ Similarity ^@ Belongs to the type IA topoisomerase family. http://togogenome.org/gene/1163748:MARHY_RS08520 ^@ http://purl.uniprot.org/uniprot/H8WEL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Catalyzes the ferrous insertion into protoporphyrin IX.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS11025 ^@ http://purl.uniprot.org/uniprot/H8W8G4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).|||Belongs to the CsrA/RsmA family.|||Cytoplasm|||Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core. http://togogenome.org/gene/1163748:MARHY_RS01325 ^@ http://purl.uniprot.org/uniprot/H8WCD8 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1163748:MARHY_RS07675 ^@ http://purl.uniprot.org/uniprot/H8WD65 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the quinolinate synthase family. Type 1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Cytoplasm http://togogenome.org/gene/1163748:MARHY_RS03045 ^@ http://purl.uniprot.org/uniprot/H8W4T7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutamine synthetase family.|||Cytoplasm|||Oligomer of 12 subunits arranged in the form of two hexagons. http://togogenome.org/gene/1163748:MARHY_RS07330 ^@ http://purl.uniprot.org/uniprot/H8WCI5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DEAD box helicase family. RhlB subfamily.|||Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.|||Cytoplasm|||DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA. http://togogenome.org/gene/1163748:MARHY_RS02815 ^@ http://purl.uniprot.org/uniprot/H8W478 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/1163748:MARHY_RS04330 ^@ http://purl.uniprot.org/uniprot/H8W6X7 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS11315 ^@ http://purl.uniprot.org/uniprot/H8W936 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.|||Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).|||Binds 1 Mg(2+) ion per subunit.|||Monomer. http://togogenome.org/gene/1163748:MARHY_RS01905 ^@ http://purl.uniprot.org/uniprot/H8WDM5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UbiD family.|||Binds 1 prenylated FMN (prenyl-FMN) per subunit.|||Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.|||Cell membrane|||Homohexamer. http://togogenome.org/gene/1163748:MARHY_RS04065 ^@ http://purl.uniprot.org/uniprot/H8W6B5 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1163748:MARHY_RS07170 ^@ http://purl.uniprot.org/uniprot/H8WBY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane