http://togogenome.org/gene/1318466:BN854_RS05120 ^@ http://purl.uniprot.org/uniprot/U4KLC0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsY family.|||Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.|||Cell membrane|||Probably interacts with PlsX. http://togogenome.org/gene/1318466:BN854_RS04560 ^@ http://purl.uniprot.org/uniprot/U4KRV5 ^@ Similarity ^@ Belongs to the lipase/esterase LIP3/BchO family. http://togogenome.org/gene/1318466:BN854_RS00795 ^@ http://purl.uniprot.org/uniprot/U4KQZ5 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/1318466:BN854_RS04485 ^@ http://purl.uniprot.org/uniprot/U4KRV0 ^@ Similarity|||Subunit ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.|||Homodimer. http://togogenome.org/gene/1318466:BN854_RS01945 ^@ http://purl.uniprot.org/uniprot/U4KK83 ^@ Function|||Similarity ^@ Belongs to the mannonate dehydratase family.|||Catalyzes the dehydration of D-mannonate. http://togogenome.org/gene/1318466:BN854_RS05960 ^@ http://purl.uniprot.org/uniprot/U4KS62 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/1318466:BN854_RS05810 ^@ http://purl.uniprot.org/uniprot/U4KS50 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS00705 ^@ http://purl.uniprot.org/uniprot/U4KNF5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/1318466:BN854_RS06285 ^@ http://purl.uniprot.org/uniprot/U4KLQ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1318466:BN854_RS06365 ^@ http://purl.uniprot.org/uniprot/U4KLK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS06335 ^@ http://purl.uniprot.org/uniprot/U4KLQ5 ^@ Caution|||Function|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. http://togogenome.org/gene/1318466:BN854_RS06225 ^@ http://purl.uniprot.org/uniprot/U4KS84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase gamma chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. http://togogenome.org/gene/1318466:BN854_RS02815 ^@ http://purl.uniprot.org/uniprot/U4KRG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS05565 ^@ http://purl.uniprot.org/uniprot/U4KQJ2 ^@ Function|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.|||This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/1318466:BN854_RS07830 ^@ http://purl.uniprot.org/uniprot/U4KJT6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell membrane http://togogenome.org/gene/1318466:BN854_RS01885 ^@ http://purl.uniprot.org/uniprot/U4KP21 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS04585 ^@ http://purl.uniprot.org/uniprot/U4KRV7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 28 family. http://togogenome.org/gene/1318466:BN854_RS01835 ^@ http://purl.uniprot.org/uniprot/U4KP13 ^@ Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. http://togogenome.org/gene/1318466:BN854_RS05485 ^@ http://purl.uniprot.org/uniprot/U4KL85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1318466:BN854_RS07105 ^@ http://purl.uniprot.org/uniprot/U4KSF8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family. YhdE subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/1318466:BN854_RS00685 ^@ http://purl.uniprot.org/uniprot/U4KQY6 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the HPrK/P family.|||Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.|||Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).|||Homohexamer.|||The Walker A ATP-binding motif also binds Pi and PPi. http://togogenome.org/gene/1318466:BN854_RS07000 ^@ http://purl.uniprot.org/uniprot/U4KQP7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS06020 ^@ http://purl.uniprot.org/uniprot/U4KLF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS05420 ^@ http://purl.uniprot.org/uniprot/U4KLE6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DNA polymerase type-Y family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Monomer.|||Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. http://togogenome.org/gene/1318466:BN854_RS06765 ^@ http://purl.uniprot.org/uniprot/U4KQP1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1318466:BN854_RS03715 ^@ http://purl.uniprot.org/uniprot/U4KRN1 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/1318466:BN854_RS03640 ^@ http://purl.uniprot.org/uniprot/U4KRM4 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. http://togogenome.org/gene/1318466:BN854_RS07360 ^@ http://purl.uniprot.org/uniprot/U4KJJ9 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/1318466:BN854_RS01385 ^@ http://purl.uniprot.org/uniprot/U4KNR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Cytoplasm|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. http://togogenome.org/gene/1318466:BN854_RS03535 ^@ http://purl.uniprot.org/uniprot/U4KPR5 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/1318466:BN854_RS00510 ^@ http://purl.uniprot.org/uniprot/U4KNC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/1318466:BN854_RS03345 ^@ http://purl.uniprot.org/uniprot/U4KPN5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Cell membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1318466:BN854_RS06715 ^@ http://purl.uniprot.org/uniprot/U4KQN9 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1318466:BN854_RS05260 ^@ http://purl.uniprot.org/uniprot/U4KS09 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS06300 ^@ http://purl.uniprot.org/uniprot/U4KS88 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/1318466:BN854_RS07200 ^@ http://purl.uniprot.org/uniprot/U4KLV0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DnaX/STICHEL family.|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/1318466:BN854_RS03030 ^@ http://purl.uniprot.org/uniprot/U4KKM8 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily. http://togogenome.org/gene/1318466:BN854_RS02505 ^@ http://purl.uniprot.org/uniprot/U4KKG9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS02895 ^@ http://purl.uniprot.org/uniprot/U4KKJ6 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/1318466:BN854_RS01715 ^@ http://purl.uniprot.org/uniprot/U4KNY0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1318466:BN854_RS00295 ^@ http://purl.uniprot.org/uniprot/U4KJP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nlpA lipoprotein family.|||Membrane http://togogenome.org/gene/1318466:BN854_RS06730 ^@ http://purl.uniprot.org/uniprot/U4KLX0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/1318466:BN854_RS04860 ^@ http://purl.uniprot.org/uniprot/U4KRX8 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/1318466:BN854_RS04435 ^@ http://purl.uniprot.org/uniprot/U4KRU6 ^@ Similarity ^@ Belongs to the PNP/UDP phosphorylase family. http://togogenome.org/gene/1318466:BN854_RS02365 ^@ http://purl.uniprot.org/uniprot/U4KP95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/1318466:BN854_RS02985 ^@ http://purl.uniprot.org/uniprot/U4KPJ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of glycine to tRNA(Gly).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1318466:BN854_RS03965 ^@ http://purl.uniprot.org/uniprot/U4KKX0 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/1318466:BN854_RS01695 ^@ http://purl.uniprot.org/uniprot/U4KR63 ^@ Similarity ^@ Belongs to the LOG family. http://togogenome.org/gene/1318466:BN854_RS06320 ^@ http://purl.uniprot.org/uniprot/U4KQM3 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. http://togogenome.org/gene/1318466:BN854_RS06085 ^@ http://purl.uniprot.org/uniprot/U4KLM6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS04565 ^@ http://purl.uniprot.org/uniprot/U4KL45 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/1318466:BN854_RS02455 ^@ http://purl.uniprot.org/uniprot/U4KKG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CoaE family.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS01310 ^@ http://purl.uniprot.org/uniprot/U4KNQ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/1318466:BN854_RS04385 ^@ http://purl.uniprot.org/uniprot/U4KRU2 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).|||Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS02420 ^@ http://purl.uniprot.org/uniprot/U4KRC9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/1318466:BN854_RS06270 ^@ http://purl.uniprot.org/uniprot/U4KQM1 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/1318466:BN854_RS05245 ^@ http://purl.uniprot.org/uniprot/U4KLD4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS02235 ^@ http://purl.uniprot.org/uniprot/U4KKB5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS03495 ^@ http://purl.uniprot.org/uniprot/U4KKR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS03690 ^@ http://purl.uniprot.org/uniprot/U4KRM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS00600 ^@ http://purl.uniprot.org/uniprot/U4KJK9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI family.|||Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS05410 ^@ http://purl.uniprot.org/uniprot/U4KQI6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AP endonuclease 2 family.|||Binds 3 Zn(2+) ions.|||Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. http://togogenome.org/gene/1318466:BN854_RS06420 ^@ http://purl.uniprot.org/uniprot/U4KQM7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1318466:BN854_RS00490 ^@ http://purl.uniprot.org/uniprot/U4KQX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribonuclease M5 family.|||Cytoplasm|||Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step. http://togogenome.org/gene/1318466:BN854_RS03305 ^@ http://purl.uniprot.org/uniprot/U4KKP4 ^@ Similarity ^@ In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.|||In the N-terminal section; belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1318466:BN854_RS04410 ^@ http://purl.uniprot.org/uniprot/U4KRU4 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/1318466:BN854_RS01840 ^@ http://purl.uniprot.org/uniprot/U4KR84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1318466:BN854_RS02015 ^@ http://purl.uniprot.org/uniprot/U4KR97 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS04890 ^@ http://purl.uniprot.org/uniprot/U4KL83 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS01830 ^@ http://purl.uniprot.org/uniprot/U4KK12 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS07180 ^@ http://purl.uniprot.org/uniprot/U4KQQ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS05560 ^@ http://purl.uniprot.org/uniprot/U4KL95 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccD/PCCB family.|||Binds 1 zinc ion per subunit.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS05570 ^@ http://purl.uniprot.org/uniprot/U4KS32 ^@ Function ^@ This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/1318466:BN854_RS03665 ^@ http://purl.uniprot.org/uniprot/U4KRM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/1318466:BN854_RS04755 ^@ http://purl.uniprot.org/uniprot/U4KQD3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS01525 ^@ http://purl.uniprot.org/uniprot/U4KNS8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/1318466:BN854_RS05985 ^@ http://purl.uniprot.org/uniprot/U4KS64 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS06675 ^@ http://purl.uniprot.org/uniprot/U4KLU2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/1318466:BN854_RS07155 ^@ http://purl.uniprot.org/uniprot/U4KSG2 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS04970 ^@ http://purl.uniprot.org/uniprot/U4KLA3 ^@ Function|||Similarity ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.|||In the C-terminal section; belongs to the NAD synthetase family. http://togogenome.org/gene/1318466:BN854_RS02855 ^@ http://purl.uniprot.org/uniprot/U4KKB0 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 9 family. http://togogenome.org/gene/1318466:BN854_RS02620 ^@ http://purl.uniprot.org/uniprot/U4KRE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1318466:BN854_RS07910 ^@ http://purl.uniprot.org/uniprot/U4KSE4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of a guanine in 16S rRNA. http://togogenome.org/gene/1318466:BN854_RS06145 ^@ http://purl.uniprot.org/uniprot/U4KLH3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.|||Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).|||Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS05580 ^@ http://purl.uniprot.org/uniprot/U4KLH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0410 family.|||Membrane http://togogenome.org/gene/1318466:BN854_RS02450 ^@ http://purl.uniprot.org/uniprot/U4KKE0 ^@ Similarity|||Subunit ^@ Belongs to the FPG family.|||Monomer. http://togogenome.org/gene/1318466:BN854_RS04720 ^@ http://purl.uniprot.org/uniprot/U4KL76 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/1318466:BN854_RS04865 ^@ http://purl.uniprot.org/uniprot/U4KL80 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/1318466:BN854_RS02020 ^@ http://purl.uniprot.org/uniprot/U4KK91 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS02410 ^@ http://purl.uniprot.org/uniprot/U4KK61 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/1318466:BN854_RS02055 ^@ http://purl.uniprot.org/uniprot/U4KK31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-C family. PolC subfamily.|||Cytoplasm|||Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/1318466:BN854_RS04620 ^@ http://purl.uniprot.org/uniprot/U4KL66 ^@ Similarity ^@ Belongs to the lipase/esterase LIP3/BchO family. http://togogenome.org/gene/1318466:BN854_RS02600 ^@ http://purl.uniprot.org/uniprot/U4KKF9 ^@ Similarity ^@ Belongs to the UxaA family. http://togogenome.org/gene/1318466:BN854_RS06785 ^@ http://purl.uniprot.org/uniprot/U4KLS1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/1318466:BN854_RS02330 ^@ http://purl.uniprot.org/uniprot/U4KKF0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. PriA subfamily.|||Component of the primosome.|||Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. http://togogenome.org/gene/1318466:BN854_RS02325 ^@ http://purl.uniprot.org/uniprot/U4KKC6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/1318466:BN854_RS01245 ^@ http://purl.uniprot.org/uniprot/U4KJZ7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1318466:BN854_RS06195 ^@ http://purl.uniprot.org/uniprot/U4KLH9 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/1318466:BN854_RS04630 ^@ http://purl.uniprot.org/uniprot/U4KQB8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/1318466:BN854_RS06445 ^@ http://purl.uniprot.org/uniprot/U4KQM8 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/1318466:BN854_RS06305 ^@ http://purl.uniprot.org/uniprot/U4KLQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS00875 ^@ http://purl.uniprot.org/uniprot/U4KJW3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/1318466:BN854_RS04895 ^@ http://purl.uniprot.org/uniprot/U4KL94 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1318466:BN854_RS04450 ^@ http://purl.uniprot.org/uniprot/U4KKW9 ^@ Caution|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS04705 ^@ http://purl.uniprot.org/uniprot/U4KQC7 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/1318466:BN854_RS05390 ^@ http://purl.uniprot.org/uniprot/U4KLE4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS01360 ^@ http://purl.uniprot.org/uniprot/U4KNQ8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M3B family.|||Binds 1 zinc ion.|||Has oligopeptidase activity and degrades a variety of small bioactive peptides. http://togogenome.org/gene/1318466:BN854_RS00760 ^@ http://purl.uniprot.org/uniprot/U4KJM2 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-I family. http://togogenome.org/gene/1318466:BN854_RS05440 ^@ http://purl.uniprot.org/uniprot/U4KS22 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseA family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/1318466:BN854_RS03215 ^@ http://purl.uniprot.org/uniprot/U4KKF7 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/1318466:BN854_RS06580 ^@ http://purl.uniprot.org/uniprot/U4KLT2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1318466:BN854_RS01345 ^@ http://purl.uniprot.org/uniprot/U4KK08 ^@ Similarity ^@ Belongs to the AlaDH/PNT family. http://togogenome.org/gene/1318466:BN854_RS00005 ^@ http://purl.uniprot.org/uniprot/U4KJL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/1318466:BN854_RS02685 ^@ http://purl.uniprot.org/uniprot/U4KK88 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/1318466:BN854_RS06025 ^@ http://purl.uniprot.org/uniprot/U4KQL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS00210 ^@ http://purl.uniprot.org/uniprot/U4KJP0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1318466:BN854_RS00605 ^@ http://purl.uniprot.org/uniprot/U4KND9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsaE family.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS03760 ^@ http://purl.uniprot.org/uniprot/U4KPV1 ^@ Similarity ^@ Belongs to the peptidase S51 family. http://togogenome.org/gene/1318466:BN854_RS06220 ^@ http://purl.uniprot.org/uniprot/U4KQL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/1318466:BN854_RS06990 ^@ http://purl.uniprot.org/uniprot/U4KLY9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ApbE family.|||Cell inner membrane|||Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.|||Magnesium. Can also use manganese. http://togogenome.org/gene/1318466:BN854_RS01230 ^@ http://purl.uniprot.org/uniprot/U4KJT0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/1318466:BN854_RS03275 ^@ http://purl.uniprot.org/uniprot/U4KRJ5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/1318466:BN854_RS02525 ^@ http://purl.uniprot.org/uniprot/U4KKE9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1318466:BN854_RS07025 ^@ http://purl.uniprot.org/uniprot/U4KQP8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS05075 ^@ http://purl.uniprot.org/uniprot/U4KL30 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/1318466:BN854_RS06390 ^@ http://purl.uniprot.org/uniprot/U4KLK6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS01395 ^@ http://purl.uniprot.org/uniprot/U4KK14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmG family. TrmFO subfamily.|||Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS04905 ^@ http://purl.uniprot.org/uniprot/U4KQF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/1318466:BN854_RS05630 ^@ http://purl.uniprot.org/uniprot/U4KLH6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1318466:BN854_RS02435 ^@ http://purl.uniprot.org/uniprot/U4KK62 ^@ Function|||Similarity ^@ Belongs to the UPF0122 family.|||Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein. http://togogenome.org/gene/1318466:BN854_RS07035 ^@ http://purl.uniprot.org/uniprot/U4KLW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/1318466:BN854_RS05575 ^@ http://purl.uniprot.org/uniprot/U4KLG4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS06450 ^@ http://purl.uniprot.org/uniprot/U4KS97 ^@ Similarity ^@ Belongs to the peptidase C59 family. http://togogenome.org/gene/1318466:BN854_RS01785 ^@ http://purl.uniprot.org/uniprot/U4KK07 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Cytoplasm|||Homodimer.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/1318466:BN854_RS06330 ^@ http://purl.uniprot.org/uniprot/U4KLQ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6. http://togogenome.org/gene/1318466:BN854_RS05070 ^@ http://purl.uniprot.org/uniprot/U4KLB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.|||Belongs to the RNR ribonuclease family. RNase R subfamily.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS06415 ^@ http://purl.uniprot.org/uniprot/U4KLK9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1318466:BN854_RS01995 ^@ http://purl.uniprot.org/uniprot/U4KK89 ^@ Similarity ^@ Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. http://togogenome.org/gene/1318466:BN854_RS06215 ^@ http://purl.uniprot.org/uniprot/U4KLI3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/1318466:BN854_RS02540 ^@ http://purl.uniprot.org/uniprot/U4KPC3 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvA family.|||Cytoplasm|||Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.|||Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/1318466:BN854_RS00270 ^@ http://purl.uniprot.org/uniprot/U4KJN8 ^@ Similarity ^@ Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/1318466:BN854_RS04395 ^@ http://purl.uniprot.org/uniprot/U4KL40 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/1318466:BN854_RS06175 ^@ http://purl.uniprot.org/uniprot/U4KQL7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase RlmH family.|||Cytoplasm|||Homodimer.|||Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. http://togogenome.org/gene/1318466:BN854_RS02825 ^@ http://purl.uniprot.org/uniprot/U4KKK6 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/1318466:BN854_RS06745 ^@ http://purl.uniprot.org/uniprot/U4KSD5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1318466:BN854_RS07515 ^@ http://purl.uniprot.org/uniprot/U4KLY4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS01900 ^@ http://purl.uniprot.org/uniprot/U4KKA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS01570 ^@ http://purl.uniprot.org/uniprot/U4KR51 ^@ Function|||Similarity ^@ Belongs to the TrhO family.|||Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs. http://togogenome.org/gene/1318466:BN854_RS04570 ^@ http://purl.uniprot.org/uniprot/U4KL60 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/1318466:BN854_RS06490 ^@ http://purl.uniprot.org/uniprot/U4KQN0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1318466:BN854_RS07310 ^@ http://purl.uniprot.org/uniprot/U4KSH3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1318466:BN854_RS06685 ^@ http://purl.uniprot.org/uniprot/U4KLP6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/1318466:BN854_RS06960 ^@ http://purl.uniprot.org/uniprot/U4KLW3 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidine kinase family.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS02475 ^@ http://purl.uniprot.org/uniprot/U4KKE3 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS01170 ^@ http://purl.uniprot.org/uniprot/U4KJZ0 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/1318466:BN854_RS07500 ^@ http://purl.uniprot.org/uniprot/U4KSB4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS02925 ^@ http://purl.uniprot.org/uniprot/U4KKL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS06665 ^@ http://purl.uniprot.org/uniprot/U4KQN7 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/1318466:BN854_RS02085 ^@ http://purl.uniprot.org/uniprot/U4KP52 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/1318466:BN854_RS01555 ^@ http://purl.uniprot.org/uniprot/U4KK42 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/1318466:BN854_RS00640 ^@ http://purl.uniprot.org/uniprot/U4KJS9 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/1318466:BN854_RS03480 ^@ http://purl.uniprot.org/uniprot/U4KKJ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/1318466:BN854_RS06515 ^@ http://purl.uniprot.org/uniprot/U4KQN1 ^@ Function|||Similarity ^@ Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.|||Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.|||Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. http://togogenome.org/gene/1318466:BN854_RS04695 ^@ http://purl.uniprot.org/uniprot/U4KL73 ^@ Similarity ^@ Belongs to the ribF family. http://togogenome.org/gene/1318466:BN854_RS04510 ^@ http://purl.uniprot.org/uniprot/U4KRV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0154 family.|||Membrane http://togogenome.org/gene/1318466:BN854_RS05320 ^@ http://purl.uniprot.org/uniprot/U4KLE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/1318466:BN854_RS02810 ^@ http://purl.uniprot.org/uniprot/U4KPG3 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1318466:BN854_RS06055 ^@ http://purl.uniprot.org/uniprot/U4KS70 ^@ Similarity ^@ Belongs to the helicase family. RecG subfamily. http://togogenome.org/gene/1318466:BN854_RS02115 ^@ http://purl.uniprot.org/uniprot/U4KP57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS06680 ^@ http://purl.uniprot.org/uniprot/U4KLU4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/1318466:BN854_RS06265 ^@ http://purl.uniprot.org/uniprot/U4KLI9 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/1318466:BN854_RS02080 ^@ http://purl.uniprot.org/uniprot/U4KK34 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/1318466:BN854_RS07075 ^@ http://purl.uniprot.org/uniprot/U4KQQ0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.|||Belongs to the organic radical-activating enzymes family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS01630 ^@ http://purl.uniprot.org/uniprot/U4KK47 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/1318466:BN854_RS02920 ^@ http://purl.uniprot.org/uniprot/U4KKJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS06010 ^@ http://purl.uniprot.org/uniprot/U4KLL7 ^@ Function|||Similarity ^@ Belongs to the flavodoxin family.|||Low-potential electron donor to a number of redox enzymes. http://togogenome.org/gene/1318466:BN854_RS03045 ^@ http://purl.uniprot.org/uniprot/U4KRH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/1318466:BN854_RS06370 ^@ http://purl.uniprot.org/uniprot/U4KQM5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/1318466:BN854_RS04335 ^@ http://purl.uniprot.org/uniprot/U4KRT9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS02510 ^@ http://purl.uniprot.org/uniprot/U4KK69 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/1318466:BN854_RS02575 ^@ http://purl.uniprot.org/uniprot/U4KKF6 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS02065 ^@ http://purl.uniprot.org/uniprot/U4KRA1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1318466:BN854_RS06760 ^@ http://purl.uniprot.org/uniprot/U4KLR9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/1318466:BN854_RS02970 ^@ http://purl.uniprot.org/uniprot/U4KKK4 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/1318466:BN854_RS07510 ^@ http://purl.uniprot.org/uniprot/U4KQP5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS05090 ^@ http://purl.uniprot.org/uniprot/U4KLA7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the BPG-independent phosphoglycerate mutase family.|||Binds 2 manganese ions per subunit.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.|||Monomer. http://togogenome.org/gene/1318466:BN854_RS01240 ^@ http://purl.uniprot.org/uniprot/U4KR30 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.|||Cell inner membrane|||Mediates magnesium influx to the cytosol.|||Membrane http://togogenome.org/gene/1318466:BN854_RS01190 ^@ http://purl.uniprot.org/uniprot/U4KR26 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/1318466:BN854_RS03335 ^@ http://purl.uniprot.org/uniprot/U4KKR3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS02490 ^@ http://purl.uniprot.org/uniprot/U4KPB6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/1318466:BN854_RS05165 ^@ http://purl.uniprot.org/uniprot/U4KLB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS00235 ^@ http://purl.uniprot.org/uniprot/U4KJP2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS05635 ^@ http://purl.uniprot.org/uniprot/U4KLA5 ^@ Similarity ^@ Belongs to the UDP-N-acetylglucosamine 2-epimerase family. http://togogenome.org/gene/1318466:BN854_RS06725 ^@ http://purl.uniprot.org/uniprot/U4KLV2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/1318466:BN854_RS04310 ^@ http://purl.uniprot.org/uniprot/U4KQ72 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/1318466:BN854_RS03455 ^@ http://purl.uniprot.org/uniprot/U4KKS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS03880 ^@ http://purl.uniprot.org/uniprot/U4KPW4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A monovalent cation. Ammonium or potassium.|||Belongs to the type III pantothenate kinase family.|||Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS05115 ^@ http://purl.uniprot.org/uniprot/U4KLB0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type II topoisomerase family. ParE type 2 subfamily.|||Heterotetramer composed of ParC and ParE.|||Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. http://togogenome.org/gene/1318466:BN854_RS03195 ^@ http://purl.uniprot.org/uniprot/U4KPL9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the KduI family.|||Binds 1 zinc ion per subunit.|||Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate. http://togogenome.org/gene/1318466:BN854_RS00515 ^@ http://purl.uniprot.org/uniprot/U4KQX2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.|||Cytoplasm|||In the C-terminal section; belongs to the helicase family. RecG subfamily.|||In the N-terminal section; belongs to the UvrB family. http://togogenome.org/gene/1318466:BN854_RS03890 ^@ http://purl.uniprot.org/uniprot/U4KKV8 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/1318466:BN854_RS06795 ^@ http://purl.uniprot.org/uniprot/U4KSE0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1318466:BN854_RS04670 ^@ http://purl.uniprot.org/uniprot/U4KL72 ^@ Similarity ^@ Belongs to the antibiotic N-acetyltransferase family. http://togogenome.org/gene/1318466:BN854_RS07245 ^@ http://purl.uniprot.org/uniprot/U4KM18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1318466:BN854_RS06435 ^@ http://purl.uniprot.org/uniprot/U4KLR4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/1318466:BN854_RS05160 ^@ http://purl.uniprot.org/uniprot/U4KS02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS01990 ^@ http://purl.uniprot.org/uniprot/U4KR96 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS04590 ^@ http://purl.uniprot.org/uniprot/U4KL49 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS04685 ^@ http://purl.uniprot.org/uniprot/U4KRW5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/1318466:BN854_RS04050 ^@ http://purl.uniprot.org/uniprot/U4KKR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS03020 ^@ http://purl.uniprot.org/uniprot/U4KRH5 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/1318466:BN854_RS02095 ^@ http://purl.uniprot.org/uniprot/U4KK99 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/1318466:BN854_RS06060 ^@ http://purl.uniprot.org/uniprot/U4KLM3 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family. http://togogenome.org/gene/1318466:BN854_RS00505 ^@ http://purl.uniprot.org/uniprot/U4KJK5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/1318466:BN854_RS06625 ^@ http://purl.uniprot.org/uniprot/U4KLT4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.|||Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.|||Cell membrane|||Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component). http://togogenome.org/gene/1318466:BN854_RS00615 ^@ http://purl.uniprot.org/uniprot/U4KJS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acetylates the N-terminal alanine of ribosomal protein bS18.|||Belongs to the acetyltransferase family. RimI subfamily.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS02005 ^@ http://purl.uniprot.org/uniprot/U4KK27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1318466:BN854_RS04520 ^@ http://purl.uniprot.org/uniprot/U4KL55 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphopentomutase family.|||Binds 1 or 2 manganese ions.|||Cytoplasm|||Phosphotransfer between the C1 and C5 carbon atoms of pentose. http://togogenome.org/gene/1318466:BN854_RS06505 ^@ http://purl.uniprot.org/uniprot/U4KLS3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/1318466:BN854_RS05555 ^@ http://purl.uniprot.org/uniprot/U4KLG8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccA family.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS03710 ^@ http://purl.uniprot.org/uniprot/U4KPU4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/1318466:BN854_RS04915 ^@ http://purl.uniprot.org/uniprot/U4KL87 ^@ Function|||Similarity ^@ Belongs to the relA/spoT family.|||In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. http://togogenome.org/gene/1318466:BN854_RS04965 ^@ http://purl.uniprot.org/uniprot/U4KL93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS06205 ^@ http://purl.uniprot.org/uniprot/U4KLP0 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/1318466:BN854_RS00850 ^@ http://purl.uniprot.org/uniprot/U4KJW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/1318466:BN854_RS06670 ^@ http://purl.uniprot.org/uniprot/U4KSC0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/1318466:BN854_RS02615 ^@ http://purl.uniprot.org/uniprot/U4KPD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1318466:BN854_RS07495 ^@ http://purl.uniprot.org/uniprot/U4KLJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/1318466:BN854_RS00160 ^@ http://purl.uniprot.org/uniprot/U4KJN4 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/1318466:BN854_RS03605 ^@ http://purl.uniprot.org/uniprot/U4KKK8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS06940 ^@ http://purl.uniprot.org/uniprot/U4KLY3 ^@ Similarity ^@ Belongs to the transketolase family. http://togogenome.org/gene/1318466:BN854_RS03290 ^@ http://purl.uniprot.org/uniprot/U4KKG6 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/1318466:BN854_RS06070 ^@ http://purl.uniprot.org/uniprot/U4KLG3 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/1318466:BN854_RS06360 ^@ http://purl.uniprot.org/uniprot/U4KLQ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/1318466:BN854_RS05830 ^@ http://purl.uniprot.org/uniprot/U4KQK3 ^@ Similarity ^@ Belongs to the V-ATPase D subunit family. http://togogenome.org/gene/1318466:BN854_RS02975 ^@ http://purl.uniprot.org/uniprot/U4KKM3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/1318466:BN854_RS02605 ^@ http://purl.uniprot.org/uniprot/U4KKI1 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family. http://togogenome.org/gene/1318466:BN854_RS02200 ^@ http://purl.uniprot.org/uniprot/U4KP68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/1318466:BN854_RS01295 ^@ http://purl.uniprot.org/uniprot/U4KK01 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/1318466:BN854_RS05180 ^@ http://purl.uniprot.org/uniprot/U4KQH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GtrA family.|||Membrane http://togogenome.org/gene/1318466:BN854_RS06440 ^@ http://purl.uniprot.org/uniprot/U4KLL2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/1318466:BN854_RS01865 ^@ http://purl.uniprot.org/uniprot/U4KR86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS06235 ^@ http://purl.uniprot.org/uniprot/U4KLP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. http://togogenome.org/gene/1318466:BN854_RS00500 ^@ http://purl.uniprot.org/uniprot/U4KJS2 ^@ Function|||Similarity ^@ Belongs to the SpoVG family.|||Could be involved in septation. http://togogenome.org/gene/1318466:BN854_RS04495 ^@ http://purl.uniprot.org/uniprot/U4KL52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/1318466:BN854_RS01100 ^@ http://purl.uniprot.org/uniprot/U4KJY6 ^@ Similarity ^@ Belongs to the XFP family. http://togogenome.org/gene/1318466:BN854_RS01910 ^@ http://purl.uniprot.org/uniprot/U4KP25 ^@ Similarity ^@ Belongs to the peptidase M29 family. http://togogenome.org/gene/1318466:BN854_RS05910 ^@ http://purl.uniprot.org/uniprot/U4KS58 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS06570 ^@ http://purl.uniprot.org/uniprot/U4KSA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS04265 ^@ http://purl.uniprot.org/uniprot/U4KRT3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS06375 ^@ http://purl.uniprot.org/uniprot/U4KS92 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/1318466:BN854_RS07030 ^@ http://purl.uniprot.org/uniprot/U4KSF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS00040 ^@ http://purl.uniprot.org/uniprot/U4KJI7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/1318466:BN854_RS07205 ^@ http://purl.uniprot.org/uniprot/U4KQQ5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS03350 ^@ http://purl.uniprot.org/uniprot/U4KRK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/1318466:BN854_RS02845 ^@ http://purl.uniprot.org/uniprot/U4KKJ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS02520 ^@ http://purl.uniprot.org/uniprot/U4KRD6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/1318466:BN854_RS02225 ^@ http://purl.uniprot.org/uniprot/U4KP72 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. http://togogenome.org/gene/1318466:BN854_RS02180 ^@ http://purl.uniprot.org/uniprot/U4KRA9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1318466:BN854_RS06510 ^@ http://purl.uniprot.org/uniprot/U4KLM2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/1318466:BN854_RS03490 ^@ http://purl.uniprot.org/uniprot/U4KRL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS07565 ^@ http://purl.uniprot.org/uniprot/U4KKV0 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/1318466:BN854_RS05535 ^@ http://purl.uniprot.org/uniprot/U4KL91 ^@ Function|||Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.|||Homotetramer. http://togogenome.org/gene/1318466:BN854_RS03205 ^@ http://purl.uniprot.org/uniprot/U4KKN2 ^@ Function|||Similarity ^@ Belongs to the HrcA family.|||Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. http://togogenome.org/gene/1318466:BN854_RS02555 ^@ http://purl.uniprot.org/uniprot/U4KKH5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell membrane|||Membrane http://togogenome.org/gene/1318466:BN854_RS07130 ^@ http://purl.uniprot.org/uniprot/U4KSG0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1318466:BN854_RS07270 ^@ http://purl.uniprot.org/uniprot/U4KM21 ^@ Function|||Similarity ^@ Belongs to the thymidylate kinase family.|||Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. http://togogenome.org/gene/1318466:BN854_RS00155 ^@ http://purl.uniprot.org/uniprot/U4KJM3 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/1318466:BN854_RS01355 ^@ http://purl.uniprot.org/uniprot/U4KJU7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS07195 ^@ http://purl.uniprot.org/uniprot/U4KM12 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YbaB/EbfC family.|||Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.|||Homodimer.|||nucleoid http://togogenome.org/gene/1318466:BN854_RS00860 ^@ http://purl.uniprot.org/uniprot/U4KNI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/1318466:BN854_RS02370 ^@ http://purl.uniprot.org/uniprot/U4KRC5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF2.|||Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. http://togogenome.org/gene/1318466:BN854_RS03660 ^@ http://purl.uniprot.org/uniprot/U4KPT5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type-II 3-dehydroquinase family.|||Catalyzes a trans-dehydration via an enolate intermediate.|||Homododecamer. http://togogenome.org/gene/1318466:BN854_RS06050 ^@ http://purl.uniprot.org/uniprot/U4KQL2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsX family.|||Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.|||Cytoplasm|||Homodimer. Probably interacts with PlsY. http://togogenome.org/gene/1318466:BN854_RS04815 ^@ http://purl.uniprot.org/uniprot/U4KL74 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/1318466:BN854_RS02335 ^@ http://purl.uniprot.org/uniprot/U4KK56 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/1318466:BN854_RS03685 ^@ http://purl.uniprot.org/uniprot/U4KPU0 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/1318466:BN854_RS00165 ^@ http://purl.uniprot.org/uniprot/U4KJJ2 ^@ Function|||Similarity ^@ A P subtype restriction enzyme that recognizes the double-stranded unmethylated sequence 5'-GATC-3'.|||Belongs to the DpnII type II restriction endonuclease family. http://togogenome.org/gene/1318466:BN854_RS00305 ^@ http://purl.uniprot.org/uniprot/U4KJJ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS02210 ^@ http://purl.uniprot.org/uniprot/U4KKB2 ^@ Similarity ^@ Belongs to the V-ATPase F subunit family. http://togogenome.org/gene/1318466:BN854_RS00300 ^@ http://purl.uniprot.org/uniprot/U4KJQ0 ^@ Similarity ^@ Belongs to the peptidase S51 family. http://togogenome.org/gene/1318466:BN854_RS03440 ^@ http://purl.uniprot.org/uniprot/U4KPP8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS05175 ^@ http://purl.uniprot.org/uniprot/U4KL44 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M3B family.|||Binds 1 zinc ion.|||Has oligopeptidase activity and degrades a variety of small bioactive peptides. http://togogenome.org/gene/1318466:BN854_RS01270 ^@ http://purl.uniprot.org/uniprot/U4KJZ9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/1318466:BN854_RS07240 ^@ http://purl.uniprot.org/uniprot/U4KLZ2 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 1 family. http://togogenome.org/gene/1318466:BN854_RS07545 ^@ http://purl.uniprot.org/uniprot/U4KRB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/1318466:BN854_RS04960 ^@ http://purl.uniprot.org/uniprot/U4KRY6 ^@ Function|||Similarity ^@ Belongs to the RecD family. RecD-like subfamily.|||DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity. http://togogenome.org/gene/1318466:BN854_RS05435 ^@ http://purl.uniprot.org/uniprot/U4KQI7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseB family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/1318466:BN854_RS06660 ^@ http://purl.uniprot.org/uniprot/U4KLP2 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/1318466:BN854_RS01425 ^@ http://purl.uniprot.org/uniprot/U4KK24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/1318466:BN854_RS03560 ^@ http://purl.uniprot.org/uniprot/U4KPR8 ^@ Similarity ^@ Belongs to the Iojap/RsfS family. http://togogenome.org/gene/1318466:BN854_RS03220 ^@ http://purl.uniprot.org/uniprot/U4KPM1 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/1318466:BN854_RS02070 ^@ http://purl.uniprot.org/uniprot/U4KK96 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1318466:BN854_RS02205 ^@ http://purl.uniprot.org/uniprot/U4KRB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane http://togogenome.org/gene/1318466:BN854_RS02175 ^@ http://purl.uniprot.org/uniprot/U4KP64 ^@ Similarity ^@ Belongs to the CvfB family. http://togogenome.org/gene/1318466:BN854_RS02385 ^@ http://purl.uniprot.org/uniprot/U4KK59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RecX family.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS02830 ^@ http://purl.uniprot.org/uniprot/U4KKA7 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/1318466:BN854_RS03670 ^@ http://purl.uniprot.org/uniprot/U4KKT7 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/1318466:BN854_RS06920 ^@ http://purl.uniprot.org/uniprot/U4KLS7 ^@ Similarity ^@ Belongs to the ParB family. http://togogenome.org/gene/1318466:BN854_RS05965 ^@ http://purl.uniprot.org/uniprot/U4KLL1 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS03930 ^@ http://purl.uniprot.org/uniprot/U4KPX3 ^@ Similarity ^@ Belongs to the UDPGP type 2 family. http://togogenome.org/gene/1318466:BN854_RS04545 ^@ http://purl.uniprot.org/uniprot/U4KL57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/1318466:BN854_RS01365 ^@ http://purl.uniprot.org/uniprot/U4KR39 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/1318466:BN854_RS00675 ^@ http://purl.uniprot.org/uniprot/U4KJL4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/1318466:BN854_RS02955 ^@ http://purl.uniprot.org/uniprot/U4KKC4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/1318466:BN854_RS02990 ^@ http://purl.uniprot.org/uniprot/U4KRH3 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/1318466:BN854_RS05550 ^@ http://purl.uniprot.org/uniprot/U4KLG1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/1318466:BN854_RS06635 ^@ http://purl.uniprot.org/uniprot/U4KLN9 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/1318466:BN854_RS04465 ^@ http://purl.uniprot.org/uniprot/U4KL33 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/1318466:BN854_RS05430 ^@ http://purl.uniprot.org/uniprot/U4KL78 ^@ Similarity ^@ Belongs to the TlyA family. http://togogenome.org/gene/1318466:BN854_RS05945 ^@ http://purl.uniprot.org/uniprot/U4KLL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS04710 ^@ http://purl.uniprot.org/uniprot/U4KRW6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.|||Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.|||Homodimer. http://togogenome.org/gene/1318466:BN854_RS00345 ^@ http://purl.uniprot.org/uniprot/U4KJP8 ^@ Function|||Similarity ^@ Belongs to the PduL family.|||Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. http://togogenome.org/gene/1318466:BN854_RS06775 ^@ http://purl.uniprot.org/uniprot/U4KLV5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/1318466:BN854_RS04910 ^@ http://purl.uniprot.org/uniprot/U4KRY2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1318466:BN854_RS00635 ^@ http://purl.uniprot.org/uniprot/U4KQY1 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/1318466:BN854_RS06690 ^@ http://purl.uniprot.org/uniprot/U4KQN8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/1318466:BN854_RS06965 ^@ http://purl.uniprot.org/uniprot/U4KLY6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.|||Binds the 23S rRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1318466:BN854_RS05950 ^@ http://purl.uniprot.org/uniprot/U4KLE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS05365 ^@ http://purl.uniprot.org/uniprot/U4KLE1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS02405 ^@ http://purl.uniprot.org/uniprot/U4KKF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.|||Cytoplasm|||Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity. http://togogenome.org/gene/1318466:BN854_RS07890 ^@ http://purl.uniprot.org/uniprot/U4KLL9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MrnC RNase family.|||Cytoplasm|||Homodimer.|||Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors. http://togogenome.org/gene/1318466:BN854_RS06695 ^@ http://purl.uniprot.org/uniprot/U4KSC2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1318466:BN854_RS02545 ^@ http://purl.uniprot.org/uniprot/U4KRD8 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvB family.|||Cytoplasm|||Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.|||Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA. http://togogenome.org/gene/1318466:BN854_RS05310 ^@ http://purl.uniprot.org/uniprot/U4KS13 ^@ Similarity ^@ Belongs to the peptidase M13 family. http://togogenome.org/gene/1318466:BN854_RS03470 ^@ http://purl.uniprot.org/uniprot/U4KRL0 ^@ Similarity ^@ Belongs to the SHMT family. http://togogenome.org/gene/1318466:BN854_RS06750 ^@ http://purl.uniprot.org/uniprot/U4KLV4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/1318466:BN854_RS00700 ^@ http://purl.uniprot.org/uniprot/U4KJL6 ^@ Function|||Similarity ^@ Belongs to the WhiA family.|||Involved in cell division and chromosome segregation. http://togogenome.org/gene/1318466:BN854_RS00310 ^@ http://purl.uniprot.org/uniprot/U4KN89 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS02075 ^@ http://purl.uniprot.org/uniprot/U4KKC2 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RlmN family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.|||Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. http://togogenome.org/gene/1318466:BN854_RS06790 ^@ http://purl.uniprot.org/uniprot/U4KQP2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/1318466:BN854_RS01180 ^@ http://purl.uniprot.org/uniprot/U4KJS3 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.|||Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. http://togogenome.org/gene/1318466:BN854_RS06500 ^@ http://purl.uniprot.org/uniprot/U4KLR8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1318466:BN854_RS02150 ^@ http://purl.uniprot.org/uniprot/U4KP61 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1318466:BN854_RS03510 ^@ http://purl.uniprot.org/uniprot/U4KPR1 ^@ Similarity ^@ Belongs to the UPF0473 family. http://togogenome.org/gene/1318466:BN854_RS05335 ^@ http://purl.uniprot.org/uniprot/U4KS15 ^@ Similarity ^@ Belongs to the carotenoid/retinoid oxidoreductase family. http://togogenome.org/gene/1318466:BN854_RS05255 ^@ http://purl.uniprot.org/uniprot/U4KQI0 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/1318466:BN854_RS05425 ^@ http://purl.uniprot.org/uniprot/U4KLF4 ^@ Function|||Similarity ^@ Belongs to the RecN family.|||May be involved in recombinational repair of damaged DNA. http://togogenome.org/gene/1318466:BN854_RS07020 ^@ http://purl.uniprot.org/uniprot/U4KLT7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.|||Binds 2 [4Fe-4S] clusters per subunit.|||Cell membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/1318466:BN854_RS00670 ^@ http://purl.uniprot.org/uniprot/U4KJU1 ^@ Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. http://togogenome.org/gene/1318466:BN854_RS02220 ^@ http://purl.uniprot.org/uniprot/U4KK45 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. http://togogenome.org/gene/1318466:BN854_RS05385 ^@ http://purl.uniprot.org/uniprot/U4KS19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS01470 ^@ http://purl.uniprot.org/uniprot/U4KK28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uridine kinase family.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS06740 ^@ http://purl.uniprot.org/uniprot/U4KQP0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/1318466:BN854_RS07095 ^@ http://purl.uniprot.org/uniprot/U4KLU5 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/1318466:BN854_RS05360 ^@ http://purl.uniprot.org/uniprot/U4KS17 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/1318466:BN854_RS03115 ^@ http://purl.uniprot.org/uniprot/U4KRI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PEP-utilizing enzyme family.|||Cytoplasm|||General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). http://togogenome.org/gene/1318466:BN854_RS03120 ^@ http://purl.uniprot.org/uniprot/U4KKM2 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/1318466:BN854_RS05135 ^@ http://purl.uniprot.org/uniprot/U4KS00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/1318466:BN854_RS04075 ^@ http://purl.uniprot.org/uniprot/U4KKY4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/1318466:BN854_RS04415 ^@ http://purl.uniprot.org/uniprot/U4KL28 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/1318466:BN854_RS04715 ^@ http://purl.uniprot.org/uniprot/U4KL62 ^@ Caution|||Function|||Similarity ^@ Belongs to the RNase HII family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS03645 ^@ http://purl.uniprot.org/uniprot/U4KKT5 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/1318466:BN854_RS06295 ^@ http://purl.uniprot.org/uniprot/U4KQM2 ^@ Function ^@ Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. http://togogenome.org/gene/1318466:BN854_RS05000 ^@ http://purl.uniprot.org/uniprot/U4KL21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/1318466:BN854_RS04610 ^@ http://purl.uniprot.org/uniprot/U4KRV9 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by fructose 1,6-bisphosphate (FBP).|||Belongs to the LDH/MDH superfamily. LDH family.|||Catalyzes the conversion of lactate to pyruvate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS04985 ^@ http://purl.uniprot.org/uniprot/U4KRY8 ^@ Function|||Similarity ^@ Belongs to the methylglyoxal synthase family.|||Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. http://togogenome.org/gene/1318466:BN854_RS03940 ^@ http://purl.uniprot.org/uniprot/U4KKW7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/1318466:BN854_RS00325 ^@ http://purl.uniprot.org/uniprot/U4KJQ3 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS01325 ^@ http://purl.uniprot.org/uniprot/U4KK09 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1318466:BN854_RS00035 ^@ http://purl.uniprot.org/uniprot/U4KJM1 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/1318466:BN854_RS00290 ^@ http://purl.uniprot.org/uniprot/U4KQV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1318466:BN854_RS04460 ^@ http://purl.uniprot.org/uniprot/U4KRU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1318466:BN854_RS01255 ^@ http://purl.uniprot.org/uniprot/U4KJT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS02580 ^@ http://purl.uniprot.org/uniprot/U4KKH8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/1318466:BN854_RS01430 ^@ http://purl.uniprot.org/uniprot/U4KJV6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer. http://togogenome.org/gene/1318466:BN854_RS04525 ^@ http://purl.uniprot.org/uniprot/U4KKX6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerC subfamily.|||Belongs to the 'phage' integrase family. XerD subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/1318466:BN854_RS07440 ^@ http://purl.uniprot.org/uniprot/U4KKM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/1318466:BN854_RS06995 ^@ http://purl.uniprot.org/uniprot/U4KLT6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS01620 ^@ http://purl.uniprot.org/uniprot/U4KNV2 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/1318466:BN854_RS02440 ^@ http://purl.uniprot.org/uniprot/U4KPA8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/1318466:BN854_RS06800 ^@ http://purl.uniprot.org/uniprot/U4KLV8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/1318466:BN854_RS07520 ^@ http://purl.uniprot.org/uniprot/U4KSH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Cell membrane|||Membrane http://togogenome.org/gene/1318466:BN854_RS04515 ^@ http://purl.uniprot.org/uniprot/U4KL39 ^@ Similarity ^@ Belongs to the asparaginase 1 family. http://togogenome.org/gene/1318466:BN854_RS06075 ^@ http://purl.uniprot.org/uniprot/U4KQL3 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/1318466:BN854_RS02820 ^@ http://purl.uniprot.org/uniprot/U4KKI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS04675 ^@ http://purl.uniprot.org/uniprot/U4KKZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm|||Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. http://togogenome.org/gene/1318466:BN854_RS06610 ^@ http://purl.uniprot.org/uniprot/U4KLN6 ^@ Function|||Similarity ^@ Belongs to the thymidylate kinase family.|||Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. http://togogenome.org/gene/1318466:BN854_RS07060 ^@ http://purl.uniprot.org/uniprot/U4KLX3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/1318466:BN854_RS02110 ^@ http://purl.uniprot.org/uniprot/U4KK36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS00015 ^@ http://purl.uniprot.org/uniprot/U4KJI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA which binds and tethers DNA polymerases and other proteins to the DNA. The DNA replisome complex has a single clamp-loading complex (3 tau and 1 each of delta, delta', psi and chi subunits) which binds 3 Pol III cores (1 core on the leading strand and 2 on the lagging strand) each with a beta sliding clamp dimer. Additional proteins in the replisome are other copies of gamma, psi and chi, Ssb, DNA helicase and RNA primase. http://togogenome.org/gene/1318466:BN854_RS06590 ^@ http://purl.uniprot.org/uniprot/U4KQN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmI family.|||Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS06340 ^@ http://purl.uniprot.org/uniprot/U4KLK0 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with bS18 to 16S ribosomal RNA. http://togogenome.org/gene/1318466:BN854_RS05590 ^@ http://purl.uniprot.org/uniprot/U4KQJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/1318466:BN854_RS00495 ^@ http://purl.uniprot.org/uniprot/U4KJR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/1318466:BN854_RS03165 ^@ http://purl.uniprot.org/uniprot/U4KKF1 ^@ Similarity ^@ Belongs to the KHG/KDPG aldolase family. http://togogenome.org/gene/1318466:BN854_RS02230 ^@ http://purl.uniprot.org/uniprot/U4KRB3 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/1318466:BN854_RS03985 ^@ http://purl.uniprot.org/uniprot/U4KRQ0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecU family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation. http://togogenome.org/gene/1318466:BN854_RS04920 ^@ http://purl.uniprot.org/uniprot/U4KL97 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1318466:BN854_RS06805 ^@ http://purl.uniprot.org/uniprot/U4KLX7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1318466:BN854_RS07185 ^@ http://purl.uniprot.org/uniprot/U4KSG4 ^@ Similarity ^@ Belongs to the RpoE family. http://togogenome.org/gene/1318466:BN854_RS05490 ^@ http://purl.uniprot.org/uniprot/U4KQI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1318466:BN854_RS00520 ^@ http://purl.uniprot.org/uniprot/U4KJR6 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/1318466:BN854_RS02550 ^@ http://purl.uniprot.org/uniprot/U4KKF2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueA family.|||Cytoplasm|||Monomer.|||Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). http://togogenome.org/gene/1318466:BN854_RS07340 ^@ http://purl.uniprot.org/uniprot/U4KM04 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RnpA family.|||Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.|||RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. http://togogenome.org/gene/1318466:BN854_RS01215 ^@ http://purl.uniprot.org/uniprot/U4KR28 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1318466:BN854_RS05540 ^@ http://purl.uniprot.org/uniprot/U4KQJ1 ^@ Similarity ^@ Belongs to the fabD family. http://togogenome.org/gene/1318466:BN854_RS04665 ^@ http://purl.uniprot.org/uniprot/U4KL56 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/1318466:BN854_RS05380 ^@ http://purl.uniprot.org/uniprot/U4KQI5 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/1318466:BN854_RS01140 ^@ http://purl.uniprot.org/uniprot/U4KR22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1318466:BN854_RS07070 ^@ http://purl.uniprot.org/uniprot/U4KLU3 ^@ Function|||Similarity ^@ Belongs to the QueH family.|||Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). http://togogenome.org/gene/1318466:BN854_RS06720 ^@ http://purl.uniprot.org/uniprot/U4KSD0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/1318466:BN854_RS02865 ^@ http://purl.uniprot.org/uniprot/U4KRG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/1318466:BN854_RS05860 ^@ http://purl.uniprot.org/uniprot/U4KS54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane http://togogenome.org/gene/1318466:BN854_RS02675 ^@ http://purl.uniprot.org/uniprot/U4KKG8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.|||Cytoplasm|||Homotrimer.|||In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS04615 ^@ http://purl.uniprot.org/uniprot/U4KL50 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/1318466:BN854_RS04995 ^@ http://purl.uniprot.org/uniprot/U4KLA6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase subunit omega family.|||Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1318466:BN854_RS02670 ^@ http://purl.uniprot.org/uniprot/U4KRE8 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/1318466:BN854_RS01780 ^@ http://purl.uniprot.org/uniprot/U4KK87 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/1318466:BN854_RS06000 ^@ http://purl.uniprot.org/uniprot/U4KQL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS01415 ^@ http://purl.uniprot.org/uniprot/U4KR43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS02805 ^@ http://purl.uniprot.org/uniprot/U4KKA4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20B family.|||Binds 2 Zn(2+) ions per subunit. http://togogenome.org/gene/1318466:BN854_RS05185 ^@ http://purl.uniprot.org/uniprot/U4KS03 ^@ Similarity ^@ Belongs to the peptidase S66 family. http://togogenome.org/gene/1318466:BN854_RS02290 ^@ http://purl.uniprot.org/uniprot/U4KP82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/1318466:BN854_RS07120 ^@ http://purl.uniprot.org/uniprot/U4KLU6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.|||Belongs to the AAA ATPase family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Homohexamer.|||In the C-terminal section; belongs to the peptidase M41 family.|||In the central section; belongs to the AAA ATPase family. http://togogenome.org/gene/1318466:BN854_RS04795 ^@ http://purl.uniprot.org/uniprot/U4KL84 ^@ Similarity ^@ Belongs to the diphosphomevalonate decarboxylase family. http://togogenome.org/gene/1318466:BN854_RS03695 ^@ http://purl.uniprot.org/uniprot/U4KKU0 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/1318466:BN854_RS03675 ^@ http://purl.uniprot.org/uniprot/U4KKU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS01895 ^@ http://purl.uniprot.org/uniprot/U4KK79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS00905 ^@ http://purl.uniprot.org/uniprot/U4KJP3 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/1318466:BN854_RS02305 ^@ http://purl.uniprot.org/uniprot/U4KKE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/1318466:BN854_RS03235 ^@ http://purl.uniprot.org/uniprot/U4KKQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1318466:BN854_RS02870 ^@ http://purl.uniprot.org/uniprot/U4KKJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/1318466:BN854_RS04080 ^@ http://purl.uniprot.org/uniprot/U4KKZ3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/1318466:BN854_RS07100 ^@ http://purl.uniprot.org/uniprot/U4KQQ1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HSP33 family.|||Cytoplasm|||Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.|||Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive. http://togogenome.org/gene/1318466:BN854_RS06100 ^@ http://purl.uniprot.org/uniprot/U4KQL4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/1318466:BN854_RS01605 ^@ http://purl.uniprot.org/uniprot/U4KK44 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/1318466:BN854_RS04975 ^@ http://purl.uniprot.org/uniprot/U4KL19 ^@ Function|||Similarity ^@ Belongs to the NadD family.|||Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). http://togogenome.org/gene/1318466:BN854_RS00910 ^@ http://purl.uniprot.org/uniprot/U4KNI9 ^@ Similarity|||Subunit ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1318466:BN854_RS07190 ^@ http://purl.uniprot.org/uniprot/U4KLY7 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/1318466:BN854_RS00775 ^@ http://purl.uniprot.org/uniprot/U4KJU5 ^@ Similarity ^@ Belongs to the peptidase C15 family. http://togogenome.org/gene/1318466:BN854_RS03325 ^@ http://purl.uniprot.org/uniprot/U4KRJ9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/1318466:BN854_RS04885 ^@ http://purl.uniprot.org/uniprot/U4KRY0 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/1318466:BN854_RS01435 ^@ http://purl.uniprot.org/uniprot/U4KNR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/1318466:BN854_RS02430 ^@ http://purl.uniprot.org/uniprot/U4KKG2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Membrane|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/1318466:BN854_RS02300 ^@ http://purl.uniprot.org/uniprot/U4KKC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RimP family.|||Cytoplasm|||Required for maturation of 30S ribosomal subunits. http://togogenome.org/gene/1318466:BN854_RS06430 ^@ http://purl.uniprot.org/uniprot/U4KLR1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/1318466:BN854_RS00765 ^@ http://purl.uniprot.org/uniprot/U4KNG3 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/1318466:BN854_RS07055 ^@ http://purl.uniprot.org/uniprot/U4KSF4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 28 family. http://togogenome.org/gene/1318466:BN854_RS05530 ^@ http://purl.uniprot.org/uniprot/U4KLG5 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/1318466:BN854_RS03655 ^@ http://purl.uniprot.org/uniprot/U4KKL4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1318466:BN854_RS03960 ^@ http://purl.uniprot.org/uniprot/U4KRP7 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/1318466:BN854_RS04320 ^@ http://purl.uniprot.org/uniprot/U4KL32 ^@ Similarity ^@ Belongs to the BMP lipoprotein family. http://togogenome.org/gene/1318466:BN854_RS06250 ^@ http://purl.uniprot.org/uniprot/U4KS86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Membrane http://togogenome.org/gene/1318466:BN854_RS00780 ^@ http://purl.uniprot.org/uniprot/U4KJV2 ^@ Function|||Subunit ^@ Heterodimer of an alpha and a beta chain.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/1318466:BN854_RS03600 ^@ http://purl.uniprot.org/uniprot/U4KKU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/1318466:BN854_RS05315 ^@ http://purl.uniprot.org/uniprot/U4KLD5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1318466:BN854_RS01845 ^@ http://purl.uniprot.org/uniprot/U4KK75 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/1318466:BN854_RS01590 ^@ http://purl.uniprot.org/uniprot/U4KNU7 ^@ Similarity ^@ Belongs to the glycerate kinase type-1 family. http://togogenome.org/gene/1318466:BN854_RS04340 ^@ http://purl.uniprot.org/uniprot/U4KL20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS05065 ^@ http://purl.uniprot.org/uniprot/U4KLA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/1318466:BN854_RS07210 ^@ http://purl.uniprot.org/uniprot/U4KSG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MgtC/SapB family.|||Membrane http://togogenome.org/gene/1318466:BN854_RS02905 ^@ http://purl.uniprot.org/uniprot/U4KKB6 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/1318466:BN854_RS03010 ^@ http://purl.uniprot.org/uniprot/U4KPJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS02890 ^@ http://purl.uniprot.org/uniprot/U4KRG6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M32 family.|||Binds 1 zinc ion per subunit.|||Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. http://togogenome.org/gene/1318466:BN854_RS01335 ^@ http://purl.uniprot.org/uniprot/U4KNQ4 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Homodimer. http://togogenome.org/gene/1318466:BN854_RS00240 ^@ http://purl.uniprot.org/uniprot/U4KQV2 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/1318466:BN854_RS07110 ^@ http://purl.uniprot.org/uniprot/U4KLX9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA(Ile)-lysidine synthase family.|||Cytoplasm|||Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.|||The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding. http://togogenome.org/gene/1318466:BN854_RS02875 ^@ http://purl.uniprot.org/uniprot/U4KKL2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DtxR/MntR family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1318466:BN854_RS03240 ^@ http://purl.uniprot.org/uniprot/U4KKG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1318466:BN854_RS04950 ^@ http://purl.uniprot.org/uniprot/U4KL16 ^@ Similarity ^@ Belongs to the aldose epimerase family. http://togogenome.org/gene/1318466:BN854_RS05010 ^@ http://purl.uniprot.org/uniprot/U4KRZ0 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/1318466:BN854_RS05780 ^@ http://purl.uniprot.org/uniprot/U4KQK1 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/1318466:BN854_RS04700 ^@ http://purl.uniprot.org/uniprot/U4KKZ4 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/1318466:BN854_RS07115 ^@ http://purl.uniprot.org/uniprot/U4KM03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS01000 ^@ http://purl.uniprot.org/uniprot/U4KJQ2 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/1318466:BN854_RS00090 ^@ http://purl.uniprot.org/uniprot/U4KJI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/1318466:BN854_RS06955 ^@ http://purl.uniprot.org/uniprot/U4KSE6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).|||Homodimer. http://togogenome.org/gene/1318466:BN854_RS06045 ^@ http://purl.uniprot.org/uniprot/U4KLG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribonuclease III family.|||Cytoplasm|||Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.|||Homodimer. http://togogenome.org/gene/1318466:BN854_RS04880 ^@ http://purl.uniprot.org/uniprot/U4KQE7 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/1318466:BN854_RS00620 ^@ http://purl.uniprot.org/uniprot/U4KJT5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. http://togogenome.org/gene/1318466:BN854_RS03885 ^@ http://purl.uniprot.org/uniprot/U4KRP1 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/1318466:BN854_RS05680 ^@ http://purl.uniprot.org/uniprot/U4KLI2 ^@ Similarity ^@ Belongs to the bacterial sugar transferase family. http://togogenome.org/gene/1318466:BN854_RS05585 ^@ http://purl.uniprot.org/uniprot/U4KL98 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS03650 ^@ http://purl.uniprot.org/uniprot/U4KKU5 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1318466:BN854_RS07065 ^@ http://purl.uniprot.org/uniprot/U4KLZ8 ^@ Similarity ^@ Belongs to the formate--tetrahydrofolate ligase family. http://togogenome.org/gene/1318466:BN854_RS07345 ^@ http://purl.uniprot.org/uniprot/U4KM30 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/1318466:BN854_RS05840 ^@ http://purl.uniprot.org/uniprot/U4KLJ7 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. http://togogenome.org/gene/1318466:BN854_RS07150 ^@ http://purl.uniprot.org/uniprot/U4KQQ3 ^@ Cofactor ^@ Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/1318466:BN854_RS05370 ^@ http://purl.uniprot.org/uniprot/U4KLE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.|||Could methylate the ribose at the nucleotide 34 wobble position in tRNA.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS05400 ^@ http://purl.uniprot.org/uniprot/U4KLF1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1318466:BN854_RS05835 ^@ http://purl.uniprot.org/uniprot/U4KS52 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. http://togogenome.org/gene/1318466:BN854_RS01315 ^@ http://purl.uniprot.org/uniprot/U4KR35 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/1318466:BN854_RS03005 ^@ http://purl.uniprot.org/uniprot/U4KKD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/1318466:BN854_RS03505 ^@ http://purl.uniprot.org/uniprot/U4KKJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YqgF HJR family.|||Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.|||Cytoplasm http://togogenome.org/gene/1318466:BN854_RS05465 ^@ http://purl.uniprot.org/uniprot/U4KQI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1318466:BN854_RS02650 ^@ http://purl.uniprot.org/uniprot/U4KKG5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 28 family. http://togogenome.org/gene/1318466:BN854_RS01890 ^@ http://purl.uniprot.org/uniprot/U4KR88 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS04640 ^@ http://purl.uniprot.org/uniprot/U4KL53 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS06735 ^@ http://purl.uniprot.org/uniprot/U4KLR6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/1318466:BN854_RS06770 ^@ http://purl.uniprot.org/uniprot/U4KSD8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/1318466:BN854_RS03595 ^@ http://purl.uniprot.org/uniprot/U4KKS9 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/1318466:BN854_RS02945 ^@ http://purl.uniprot.org/uniprot/U4KKK1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Membrane http://togogenome.org/gene/1318466:BN854_RS05110 ^@ http://purl.uniprot.org/uniprot/U4KRZ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.|||Cell membrane|||Heterotetramer composed of ParC and ParE.|||Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. http://togogenome.org/gene/1318466:BN854_RS00030 ^@ http://purl.uniprot.org/uniprot/U4KJL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/1318466:BN854_RS02965 ^@ http://purl.uniprot.org/uniprot/U4KRH1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endoribonuclease YbeY family.|||Binds 1 zinc ion.|||Cytoplasm|||Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. http://togogenome.org/gene/1318466:BN854_RS05460 ^@ http://purl.uniprot.org/uniprot/U4KL81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1318466:BN854_RS02445 ^@ http://purl.uniprot.org/uniprot/U4KRD1 ^@ Function|||Similarity ^@ Belongs to the DNA polymerase type-A family.|||In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. http://togogenome.org/gene/1318466:BN854_RS07330 ^@ http://purl.uniprot.org/uniprot/U4KQR0 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.|||Belongs to the KhpB RNA-binding protein family.|||Cytoplasm|||Forms a complex with KhpA.|||Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH and R3H).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS04390 ^@ http://purl.uniprot.org/uniprot/U4KL25 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1318466:BN854_RS06140 ^@ http://purl.uniprot.org/uniprot/U4KLN5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1318466:BN854_RS07040 ^@ http://purl.uniprot.org/uniprot/U4KLZ6 ^@ Similarity ^@ Belongs to the OsmC/Ohr family. http://togogenome.org/gene/1318466:BN854_RS07250 ^@ http://purl.uniprot.org/uniprot/U4KLV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1318466:BN854_RS06230 ^@ http://purl.uniprot.org/uniprot/U4KLP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/1318466:BN854_RS03085 ^@ http://purl.uniprot.org/uniprot/U4KPK4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS06240 ^@ http://purl.uniprot.org/uniprot/U4KLI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Membrane http://togogenome.org/gene/1318466:BN854_RS05150 ^@ http://purl.uniprot.org/uniprot/U4KL41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/1318466:BN854_RS07385 ^@ http://purl.uniprot.org/uniprot/U4KR44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane http://togogenome.org/gene/1318466:BN854_RS06460 ^@ http://purl.uniprot.org/uniprot/U4KLR7 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/1318466:BN854_RS05980 ^@ http://purl.uniprot.org/uniprot/U4KQK9 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-allosteric. http://togogenome.org/gene/1318466:BN854_RS00130 ^@ http://purl.uniprot.org/uniprot/U4KJM0 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/1318466:BN854_RS01510 ^@ http://purl.uniprot.org/uniprot/U4KK26 ^@ Caution|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated Cas9 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA). Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs. PAM recognition is also required for catalytic activity.|||Has 2 endonuclease domains. The discontinuous RuvC-like domain cleaves the target DNA noncomplementary to crRNA while the HNH nuclease domain cleaves the target DNA complementary to crRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Binds crRNA and tracrRNA. http://togogenome.org/gene/1318466:BN854_RS05290 ^@ http://purl.uniprot.org/uniprot/U4KLD2 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/1318466:BN854_RS03355 ^@ http://purl.uniprot.org/uniprot/U4KKP9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1318466:BN854_RS07320 ^@ http://purl.uniprot.org/uniprot/U4KM27 ^@ Function|||Similarity ^@ Belongs to the RmuC family.|||Involved in DNA recombination. http://togogenome.org/gene/1318466:BN854_RS02800 ^@ http://purl.uniprot.org/uniprot/U4KKK3 ^@ Similarity|||Subunit ^@ Belongs to the RNase H family.|||Monomer. http://togogenome.org/gene/1318466:BN854_RS06165 ^@ http://purl.uniprot.org/uniprot/U4KLN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MscL family.|||Cell membrane|||Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.|||Homopentamer.|||Membrane http://togogenome.org/gene/1318466:BN854_RS06780 ^@ http://purl.uniprot.org/uniprot/U4KLX5 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/1318466:BN854_RS06315 ^@ http://purl.uniprot.org/uniprot/U4KLJ6 ^@ Similarity ^@ Belongs to the Dps family. http://togogenome.org/gene/1318466:BN854_RS01375 ^@ http://purl.uniprot.org/uniprot/U4KK17 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/1318466:BN854_RS03915 ^@ http://purl.uniprot.org/uniprot/U4KKW2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/1318466:BN854_RS02880 ^@ http://purl.uniprot.org/uniprot/U4KKB3 ^@ Similarity ^@ Belongs to the 6-phosphogluconate dehydrogenase family. http://togogenome.org/gene/1318466:BN854_RS03910 ^@ http://purl.uniprot.org/uniprot/U4KRP2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-3 family.|||Cytoplasm|||IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.|||Monomer. http://togogenome.org/gene/1318466:BN854_RS06645 ^@ http://purl.uniprot.org/uniprot/U4KSB7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/1318466:BN854_RS02780 ^@ http://purl.uniprot.org/uniprot/U4KKA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NlpA lipoprotein family.|||Membrane