http://togogenome.org/gene/1432656:X802_RS04115 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJQ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS04950 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK32 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the UPF0165 family. http://togogenome.org/gene/1432656:X802_RS07970 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLL2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1432656:X802_RS06650 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKY5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS07595 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLE5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/1432656:X802_RS00395 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHT3 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Monomer. http://togogenome.org/gene/1432656:X802_RS02665 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIY4 ^@ Similarity ^@ Belongs to the enolase family. http://togogenome.org/gene/1432656:X802_RS07790 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLG4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the thymidylate synthase ThyX family.|||Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.|||Homotetramer. http://togogenome.org/gene/1432656:X802_RS01315 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIA3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/1432656:X802_RS08600 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Membrane http://togogenome.org/gene/1432656:X802_RS03620 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJB8 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/1432656:X802_RS01245 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI82 ^@ Similarity ^@ Belongs to the UPF0166 family. http://togogenome.org/gene/1432656:X802_RS06345 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKR9 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/1432656:X802_RS10545 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMW3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6A family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/1432656:X802_RS01810 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIJ0 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/1432656:X802_RS00130 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHP4 ^@ Similarity ^@ Belongs to the GbsR family. http://togogenome.org/gene/1432656:X802_RS03775 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CitM (TC 2.A.11) transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS01545 ^@ http://purl.uniprot.org/uniprot/A0A0X1KID7 ^@ Similarity ^@ Belongs to the snRNP Sm proteins family. http://togogenome.org/gene/1432656:X802_RS06095 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKN0 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/1432656:X802_RS01575 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIF5 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/1432656:X802_RS09730 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMH1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the THI4 family.|||Homooctamer; tetramer of dimers.|||Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS05060 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK79 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/1432656:X802_RS02680 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIZ0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1432656:X802_RS04485 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJV3 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS02880 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 2 subfamily.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS08845 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.|||Belongs to the TiaS family.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS09605 ^@ http://purl.uniprot.org/uniprot/A0A0X1KME3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.|||Membrane http://togogenome.org/gene/1432656:X802_RS10005 ^@ http://purl.uniprot.org/uniprot/A0A0X1KML0 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/1432656:X802_RS01585 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIE6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS00570 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHW7 ^@ Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/1432656:X802_RS10340 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMU4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/1432656:X802_RS03635 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJH5 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Potential transporter for phosphate. http://togogenome.org/gene/1432656:X802_RS05460 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKD9 ^@ Similarity ^@ Belongs to the ACC deaminase/D-cysteine desulfhydrase family. http://togogenome.org/gene/1432656:X802_RS06300 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CetZ family.|||Cytoplasm|||Involved in cell shape control. http://togogenome.org/gene/1432656:X802_RS04215 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJS8 ^@ Similarity ^@ Belongs to the UPF0252 family. http://togogenome.org/gene/1432656:X802_RS08500 ^@ http://purl.uniprot.org/uniprot/A0A0X1KNF5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS06620 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKU2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.|||Belongs to the Holliday junction resolvase Hjc family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer. http://togogenome.org/gene/1432656:X802_RS03625 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJF7 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/1432656:X802_RS07335 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL95 ^@ Cofactor ^@ Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/1432656:X802_RS06895 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.|||Catalyzes the oxidation of L-aspartate to iminoaspartate.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS03725 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJE2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS08755 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLW5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1432656:X802_RS01715 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIH6 ^@ Similarity ^@ Belongs to the UPF0292 family. http://togogenome.org/gene/1432656:X802_RS06025 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKK6 ^@ Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Toxic component of a toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/1432656:X802_RS05105 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK48 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS08520 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLW8 ^@ Caution|||Function|||Similarity ^@ Belongs to the UbiX/PAD1 family.|||Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS08060 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLM0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M54 family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.|||Monomer.|||Probable zinc metalloprotease whose natural substrate is unknown. http://togogenome.org/gene/1432656:X802_RS00690 ^@ http://purl.uniprot.org/uniprot/A0A0X1KN06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS09610 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMF8 ^@ Similarity ^@ In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family. http://togogenome.org/gene/1432656:X802_RS10445 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMU8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS07395 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLD3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.|||Membrane http://togogenome.org/gene/1432656:X802_RS09305 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM85 ^@ Caution|||Function|||Similarity ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS03465 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJB5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS03760 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJH2 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/1432656:X802_RS10080 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMP6 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/1432656:X802_RS02640 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIW7 ^@ Similarity ^@ Belongs to the FUN14 family. http://togogenome.org/gene/1432656:X802_RS05160 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/1432656:X802_RS03730 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJH7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS06960 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL13 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS02480 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIT5 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/1432656:X802_RS01675 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIF4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.|||Cell membrane|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/1432656:X802_RS04505 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/1432656:X802_RS04605 ^@ http://purl.uniprot.org/uniprot/A0A0X1KN47 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 38 family. http://togogenome.org/gene/1432656:X802_RS00430 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHV0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 4 family.|||Binds 1 zinc ion per subunit.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/1432656:X802_RS02160 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIP3 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/1432656:X802_RS09245 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM71 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GGGP/HepGP synthase family. Group II subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/1432656:X802_RS06265 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKR1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt4 family.|||Heterodimer composed of Spt4 and Spt5.|||Stimulates transcription elongation. http://togogenome.org/gene/1432656:X802_RS03685 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJE4 ^@ Similarity ^@ Belongs to the UPF0273 family. http://togogenome.org/gene/1432656:X802_RS04720 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJY1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M32 family.|||Binds 1 zinc ion per subunit.|||Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. http://togogenome.org/gene/1432656:X802_RS06455 ^@ http://purl.uniprot.org/uniprot/A0A0X1KND5 ^@ Function ^@ Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/1432656:X802_RS04725 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK02 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/1432656:X802_RS03015 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ37 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1432656:X802_RS06950 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL10 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/1432656:X802_RS01730 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIG9 ^@ Similarity ^@ Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/1432656:X802_RS04925 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK24 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/1432656:X802_RS07550 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLC6 ^@ Function|||Similarity ^@ Belongs to the CobB/CobQ family. CobQ subfamily.|||Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. http://togogenome.org/gene/1432656:X802_RS05510 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the branched-chain polyamine synthase family.|||Cytoplasm|||Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine. http://togogenome.org/gene/1432656:X802_RS03555 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJD2 ^@ Similarity ^@ Belongs to the HupF/HypC family. http://togogenome.org/gene/1432656:X802_RS06135 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKR0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS03925 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJL0 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the UPF0165 family. http://togogenome.org/gene/1432656:X802_RS02250 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIR4 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the UPF0165 family. http://togogenome.org/gene/1432656:X802_RS00560 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHW8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS06890 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL38 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the quinolinate synthase family. Type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS05725 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKI3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal phosphopantothenate synthetase family.|||Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.|||Homodimer. http://togogenome.org/gene/1432656:X802_RS06390 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKT8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PurS family.|||Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/1432656:X802_RS01890 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIK0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the archaeal FAD synthase family.|||Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS02345 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIV3 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family. http://togogenome.org/gene/1432656:X802_RS01420 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIC8 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/1432656:X802_RS03855 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-archaeol synthase family.|||Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.|||Cell membrane http://togogenome.org/gene/1432656:X802_RS06645 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKX1 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/1432656:X802_RS10085 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMN0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1432656:X802_RS08325 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLR1 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/1432656:X802_RS08975 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1432656:X802_RS05250 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKA2 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/1432656:X802_RS05150 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK87 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.|||Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.|||Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers. http://togogenome.org/gene/1432656:X802_RS09440 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMB5 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1432656:X802_RS01140 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/1432656:X802_RS04065 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJP6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C15 family.|||Cytoplasm|||Homotetramer.|||Removes 5-oxoproline from various penultimate amino acid residues except L-proline. http://togogenome.org/gene/1432656:X802_RS08650 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLU9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1432656:X802_RS04270 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJQ0 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72. http://togogenome.org/gene/1432656:X802_RS03640 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/1432656:X802_RS01215 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI68 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS09920 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMK9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/1432656:X802_RS09125 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM52 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS02190 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIP7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose 5-phosphate isomerase family.|||Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.|||Homodimer. http://togogenome.org/gene/1432656:X802_RS04670 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJX1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.|||Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS03000 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ53 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/1432656:X802_RS01785 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIH8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Part of the 30S ribosomal subunit.|||With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. http://togogenome.org/gene/1432656:X802_RS02910 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ44 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1432656:X802_RS02340 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIR7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS05455 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKB7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS01770 ^@ http://purl.uniprot.org/uniprot/A0A0X1KII6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1432656:X802_RS08775 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM01 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.|||Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. http://togogenome.org/gene/1432656:X802_RS08790 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLZ0 ^@ Function|||Similarity ^@ Belongs to the PEP-utilizing enzyme family.|||Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. http://togogenome.org/gene/1432656:X802_RS07690 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLI6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Binds 2 Mg(2+) or Mn(2+) ions per subunit.|||Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.|||Cell membrane http://togogenome.org/gene/1432656:X802_RS10470 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMV7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/1432656:X802_RS00050 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1432656:X802_RS08030 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLL4 ^@ Similarity ^@ Belongs to the UPF0201 family. http://togogenome.org/gene/1432656:X802_RS09660 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMG7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS07515 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLD7 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family.|||Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). http://togogenome.org/gene/1432656:X802_RS08770 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLY5 ^@ Similarity ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. http://togogenome.org/gene/1432656:X802_RS09380 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMA4 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/1432656:X802_RS05205 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS04200 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJN8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS01190 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI72 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS08470 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLR7 ^@ Similarity ^@ Belongs to the UPF0107 family. http://togogenome.org/gene/1432656:X802_RS09710 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMH7 ^@ Function|||Similarity ^@ Belongs to the archaeal IMP cyclohydrolase family.|||Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP. http://togogenome.org/gene/1432656:X802_RS01380 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI97 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. C-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/1432656:X802_RS02500 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIV8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family. YhdE subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/1432656:X802_RS07865 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endonuclease V family.|||Cytoplasm|||DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. http://togogenome.org/gene/1432656:X802_RS06200 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKM4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/1432656:X802_RS00590 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHY9 ^@ Function|||Similarity ^@ Belongs to the THEP1 NTPase family.|||Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency. http://togogenome.org/gene/1432656:X802_RS01285 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI76 ^@ Similarity ^@ Belongs to the transcriptional regulator TrmB family. http://togogenome.org/gene/1432656:X802_RS01625 ^@ http://purl.uniprot.org/uniprot/A0A0X1KII1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS10285 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMU6 ^@ Similarity ^@ Belongs to the UPF0127 family. http://togogenome.org/gene/1432656:X802_RS09875 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMJ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/1432656:X802_RS07750 ^@ http://purl.uniprot.org/uniprot/A0A0X1KNB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS09955 ^@ http://purl.uniprot.org/uniprot/A0A0X1KML1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/1432656:X802_RS04615 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJW6 ^@ Function|||Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family.|||Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. http://togogenome.org/gene/1432656:X802_RS02610 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIX9 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.|||Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Homohexamer. Dimer of a homotrimer.|||Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. http://togogenome.org/gene/1432656:X802_RS10290 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMT2 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/1432656:X802_RS09665 ^@ http://purl.uniprot.org/uniprot/A0A0X1KME0 ^@ Caution|||Function|||Similarity ^@ Belongs to the TBP family.|||General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS02150 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIN5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS03935 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJK5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS00345 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHS6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS07695 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLE9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aTrm56 family.|||Cytoplasm|||Homodimer.|||Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs. http://togogenome.org/gene/1432656:X802_RS07045 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL68 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/1432656:X802_RS08925 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM10 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Forms a Heterooligomeric complex of two stacked eight-membered rings.|||Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. http://togogenome.org/gene/1432656:X802_RS01325 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIB5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS08840 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM02 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/1432656:X802_RS10430 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMR4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycerol-1-phosphate dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS06670 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKV1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS10065 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/1432656:X802_RS05285 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK96 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrK family.|||Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit.|||Heterotetramer of 2 PyrK and 2 PyrD type B subunits.|||Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). http://togogenome.org/gene/1432656:X802_RS06850 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS03735 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJF4 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs. http://togogenome.org/gene/1432656:X802_RS07725 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLH5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS07890 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLI1 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase Pus10 family.|||Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/1432656:X802_RS09845 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMI4 ^@ Function ^@ CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/1432656:X802_RS09975 ^@ http://purl.uniprot.org/uniprot/A0A0X1KML3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1432656:X802_RS10375 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMT7 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS03805 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJJ0 ^@ Similarity ^@ Belongs to the UPF0175 family. http://togogenome.org/gene/1432656:X802_RS06740 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL16 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/1432656:X802_RS08565 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLU8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.|||Monomer.|||The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity. http://togogenome.org/gene/1432656:X802_RS04875 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK37 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS02660 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIV7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/1432656:X802_RS06840 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL28 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC61-beta family.|||Cell membrane|||Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.|||Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.|||Membrane http://togogenome.org/gene/1432656:X802_RS08690 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLW9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS07175 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL49 ^@ Similarity ^@ Belongs to the UPF0251 family. http://togogenome.org/gene/1432656:X802_RS04140 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJQ8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS02690 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIW2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/1432656:X802_RS06760 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). http://togogenome.org/gene/1432656:X802_RS10145 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMN9 ^@ Similarity ^@ Belongs to the aspartate/glutamate racemases family. http://togogenome.org/gene/1432656:X802_RS03965 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJJ1 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/1432656:X802_RS03815 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJK2 ^@ Similarity ^@ Belongs to the archaeosine synthase type 1 family. http://togogenome.org/gene/1432656:X802_RS08645 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLY4 ^@ Similarity ^@ Belongs to the BlaI transcriptional regulatory family. http://togogenome.org/gene/1432656:X802_RS04970 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK57 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.|||Heterooligomer of catalytic and regulatory chains. http://togogenome.org/gene/1432656:X802_RS07710 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLG9 ^@ Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Toxic component of a toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/1432656:X802_RS10265 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMQ1 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/1432656:X802_RS00205 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHP9 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/1432656:X802_RS06130 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal histone HMF family.|||Chromosome|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS03660 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic CoaD family.|||Cytoplasm|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/1432656:X802_RS10515 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMV8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.|||Homodimer.|||Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. http://togogenome.org/gene/1432656:X802_RS09500 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMC3 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/1432656:X802_RS06865 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL11 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/1432656:X802_RS03850 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJK8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/1432656:X802_RS07660 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLF2 ^@ Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 2 family. http://togogenome.org/gene/1432656:X802_RS00150 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHP3 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/1432656:X802_RS02115 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIR3 ^@ Similarity ^@ Belongs to the HPS/KGPDC family. HPS subfamily.|||Belongs to the SIS family. PHI subfamily. http://togogenome.org/gene/1432656:X802_RS09670 ^@ http://purl.uniprot.org/uniprot/A0A0X1KME9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/1432656:X802_RS07820 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLI3 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/1432656:X802_RS03020 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ11 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e. http://togogenome.org/gene/1432656:X802_RS00535 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.|||Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS03405 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJA4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/1432656:X802_RS08350 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLP8 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/1432656:X802_RS10115 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMN2 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/1432656:X802_RS06195 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKS1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/1432656:X802_RS05230 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK74 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/1432656:X802_RS00380 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHU4 ^@ Function|||Similarity ^@ Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.|||Belongs to the archease family. http://togogenome.org/gene/1432656:X802_RS07720 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLH7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS03560 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJE8 ^@ Similarity ^@ Belongs to the HypD family. http://togogenome.org/gene/1432656:X802_RS04230 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJS6 ^@ Subunit ^@ Homotetramer. http://togogenome.org/gene/1432656:X802_RS08710 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLX0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1432656:X802_RS01765 ^@ http://purl.uniprot.org/uniprot/A0A0X1KII0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds at least 2 Zn(2+) per subunit.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1432656:X802_RS03310 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ71 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS03915 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJI8 ^@ Function|||Similarity ^@ Belongs to the group II decarboxylase family. MfnA subfamily.|||Catalyzes the decarboxylation of L-aspartate to produce beta-alanine. http://togogenome.org/gene/1432656:X802_RS02695 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ07 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/1432656:X802_RS06290 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKS5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TYW1 family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).|||Cytoplasm|||Monomer. http://togogenome.org/gene/1432656:X802_RS10540 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMV0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6B family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/1432656:X802_RS01495 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIC9 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/1432656:X802_RS00330 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHT4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS09695 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMG0 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/1432656:X802_RS08980 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS08665 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLW4 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/1432656:X802_RS04305 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJS4 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/1432656:X802_RS08630 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS01485 ^@ http://purl.uniprot.org/uniprot/A0A0X1KID0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PNP/UDP phosphorylase family.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS06190 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKN7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. Probably involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.|||Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA. http://togogenome.org/gene/1432656:X802_RS08525 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLU6 ^@ Function|||Similarity ^@ Belongs to the adenylate cyclase family. DacZ subfamily.|||Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. http://togogenome.org/gene/1432656:X802_RS06485 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/1432656:X802_RS00490 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Archaeal flagellum|||Belongs to the archaeal flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella. http://togogenome.org/gene/1432656:X802_RS00055 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHM8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS02895 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS00625 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1432656:X802_RS01410 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/1432656:X802_RS06120 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKP5 ^@ Function|||Similarity ^@ Belongs to the TFIIB family.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/1432656:X802_RS02520 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIT6 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/1432656:X802_RS07645 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLD8 ^@ Function|||Similarity ^@ Belongs to the NOP10 family.|||Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. http://togogenome.org/gene/1432656:X802_RS02325 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIS6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/1432656:X802_RS09140 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM73 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ 2 residues (Tyr-65 and Arg-68) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.|||Belongs to the sirtuin family. Class III subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. http://togogenome.org/gene/1432656:X802_RS09510 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/1432656:X802_RS02825 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1432656:X802_RS08655 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLW1 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/1432656:X802_RS00025 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHM3 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/1432656:X802_RS02920 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIZ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/1432656:X802_RS10060 ^@ http://purl.uniprot.org/uniprot/A0A0X1KML4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1432656:X802_RS05540 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKG0 ^@ Similarity ^@ Belongs to the UPF0282 family. http://togogenome.org/gene/1432656:X802_RS05935 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKJ1 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the thiamine-monophosphate kinase family.|||Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. http://togogenome.org/gene/1432656:X802_RS04580 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJZ1 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72. http://togogenome.org/gene/1432656:X802_RS01720 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIG6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal DnaG primase family.|||Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. http://togogenome.org/gene/1432656:X802_RS10525 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMV6 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. http://togogenome.org/gene/1432656:X802_RS06990 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1432656:X802_RS04915 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK34 ^@ Similarity ^@ Belongs to the BtpA family. http://togogenome.org/gene/1432656:X802_RS07610 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLE2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1432656:X802_RS07985 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS05965 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKJ5 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/1432656:X802_RS06985 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL30 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 57 family. http://togogenome.org/gene/1432656:X802_RS06260 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKN4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.|||Nucleus|||Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure. http://togogenome.org/gene/1432656:X802_RS06165 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKM0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DtdA deacylase family.|||Binds 2 Zn(2+) ions per subunit.|||D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.|||Monomer. http://togogenome.org/gene/1432656:X802_RS02845 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIY1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/1432656:X802_RS02885 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ20 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/1432656:X802_RS04335 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJR0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Potential transporter for phosphate. http://togogenome.org/gene/1432656:X802_RS07855 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLI9 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the asparaginase 1 family. GatD subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/1432656:X802_RS05675 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKF5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS00270 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHR5 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1432656:X802_RS00555 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHW9 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/1432656:X802_RS07870 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLJ2 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the archaeal riboflavin kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS04535 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJW4 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. http://togogenome.org/gene/1432656:X802_RS05755 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/1432656:X802_RS01635 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIF0 ^@ Similarity ^@ Belongs to the DeoC/FbaB aldolase family. http://togogenome.org/gene/1432656:X802_RS01185 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI71 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS01150 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI58 ^@ Caution|||Domain|||Function|||Similarity ^@ Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family.|||Contains two alpha-helical subdomains, with the 8-oxoguanine binding site located in a cleft at their interface. Contains a helix-hairpin-helix (HhH) structural motif and a Gly/Pro-rich sequence followed by a conserved Asp (HhH-GPD motif).|||DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS08675 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLX8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1432656:X802_RS09585 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS01550 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIE7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/1432656:X802_RS10325 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMS7 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/1432656:X802_RS02015 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/1432656:X802_RS06365 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKT1 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/1432656:X802_RS01075 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI38 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/1432656:X802_RS02755 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIZ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1432656:X802_RS03370 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ81 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS08785 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLZ9 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/1432656:X802_RS01440 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIB8 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. PoK subfamily.|||Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway. http://togogenome.org/gene/1432656:X802_RS05380 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKC9 ^@ Similarity ^@ Belongs to the UPF0215 family. http://togogenome.org/gene/1432656:X802_RS04860 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homotetramer; dimer of dimers.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/1432656:X802_RS07910 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/1432656:X802_RS00845 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI05 ^@ Function|||Similarity ^@ Belongs to the archaeal 6-HMPDK family.|||Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP). http://togogenome.org/gene/1432656:X802_RS00185 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHQ4 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/1432656:X802_RS07990 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS06845 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKZ0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Homodimer.|||Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS01425 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIA9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 57 family. http://togogenome.org/gene/1432656:X802_RS04190 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJR9 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/1432656:X802_RS05880 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKJ0 ^@ Cofactor|||Function|||Subunit ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/1432656:X802_RS07130 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL54 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/1432656:X802_RS03980 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJJ6 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/1432656:X802_RS06770 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKY7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/1432656:X802_RS07125 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL39 ^@ Cofactor|||Similarity ^@ Belongs to the PdaD family.|||Binds 1 pyruvoyl group covalently per subunit. http://togogenome.org/gene/1432656:X802_RS09345 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM88 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/1432656:X802_RS06055 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKM6 ^@ Similarity ^@ Belongs to the NOP5/NOP56 family. http://togogenome.org/gene/1432656:X802_RS10460 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMX6 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/1432656:X802_RS05290 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK83 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. http://togogenome.org/gene/1432656:X802_RS08455 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLW0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS01130 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI61 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/1432656:X802_RS04965 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK43 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/1432656:X802_RS05095 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK54 ^@ Function|||Similarity ^@ Belongs to the FAU-1 family.|||Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences. http://togogenome.org/gene/1432656:X802_RS03700 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJE5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecF subfamily.|||Cell membrane|||Involved in protein export.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the protein translocation apparatus. Forms a complex with SecD. http://togogenome.org/gene/1432656:X802_RS06885 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL06 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NadC/ModD family.|||Hexamer formed by 3 homodimers.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/1432656:X802_RS08595 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLX5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/1432656:X802_RS00650 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHY0 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/1432656:X802_RS09885 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMH4 ^@ Function ^@ CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/1432656:X802_RS05560 ^@ http://purl.uniprot.org/uniprot/A0A0X1KNE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1432656:X802_RS01690 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIF8 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/1432656:X802_RS07810 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLI4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1432656:X802_RS01790 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIK6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1432656:X802_RS00045 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHM2 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily. http://togogenome.org/gene/1432656:X802_RS04945 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK64 ^@ Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Toxic component of a toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/1432656:X802_RS02375 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIT4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS02170 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIQ0 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/1432656:X802_RS02060 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Cytoplasm|||Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.|||Part of the 50S ribosomal subunit. Probably part of the RNase P complex. http://togogenome.org/gene/1432656:X802_RS06610 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKV6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS07700 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLG2 ^@ Similarity ^@ Belongs to the SAM hydrolase / SAM-dependent halogenase family. http://togogenome.org/gene/1432656:X802_RS01340 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIA1 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/1432656:X802_RS04170 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJP1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.|||Homodimer. http://togogenome.org/gene/1432656:X802_RS10030 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMN8 ^@ Similarity ^@ Belongs to the peptidase S9C family. http://togogenome.org/gene/1432656:X802_RS06970 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL55 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/1432656:X802_RS03525 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJD7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS02760 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIZ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/1432656:X802_RS06715 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS03665 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJH3 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/1432656:X802_RS00190 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHQ0 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/1432656:X802_RS06175 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKP8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.|||Membrane http://togogenome.org/gene/1432656:X802_RS05305 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS03970 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJM3 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the UPF0165 family. http://togogenome.org/gene/1432656:X802_RS00375 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHT9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/1432656:X802_RS01570 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIG8 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the MRE11/RAD32 family.|||Binds 2 manganese ions per subunit.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Nuclease activity is regulated by Rad50.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. http://togogenome.org/gene/1432656:X802_RS06310 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKP4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS05275 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK84 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAC-alpha family.|||Contacts the emerging nascent chain on the ribosome.|||Homodimer. Interacts with the ribosome. Binds ribosomal RNA. http://togogenome.org/gene/1432656:X802_RS10165 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMP3 ^@ Function|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro. http://togogenome.org/gene/1432656:X802_RS05300 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1432656:X802_RS06375 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKR2 ^@ Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. http://togogenome.org/gene/1432656:X802_RS08380 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/1432656:X802_RS08050 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLK7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS1 family. http://togogenome.org/gene/1432656:X802_RS10190 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMQ2 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/1432656:X802_RS07715 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS07570 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLE7 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/1432656:X802_RS09725 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMG2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. http://togogenome.org/gene/1432656:X802_RS03565 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJD4 ^@ Similarity ^@ Belongs to the carbamoyltransferase HypF family. http://togogenome.org/gene/1432656:X802_RS01985 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIL7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1432656:X802_RS04775 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJZ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS02685 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIY7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/1432656:X802_RS01680 ^@ http://purl.uniprot.org/uniprot/A0A0X1KII8 ^@ Function ^@ Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA. http://togogenome.org/gene/1432656:X802_RS05330 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK94 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutamine synthetase family.|||Cytoplasm|||Oligomer of 12 subunits arranged in the form of two hexagons. http://togogenome.org/gene/1432656:X802_RS07450 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLE3 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/1432656:X802_RS09420 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMA5 ^@ Similarity ^@ Belongs to the UPF0248 family. http://togogenome.org/gene/1432656:X802_RS00575 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHY7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.|||Belongs to the histone-like Alba family.|||Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.|||Chromosome|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/1432656:X802_RS06140 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKL4 ^@ Function|||Similarity ^@ Belongs to the HARP family.|||RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. http://togogenome.org/gene/1432656:X802_RS04780 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS04480 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJX3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Homohexamer. Dimer of a homotrimer. http://togogenome.org/gene/1432656:X802_RS03550 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJE0 ^@ Similarity ^@ Belongs to the HupF/HypC family. http://togogenome.org/gene/1432656:X802_RS04685 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK11 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1432656:X802_RS08055 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLM7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/1432656:X802_RS08965 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM41 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSL4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. http://togogenome.org/gene/1432656:X802_RS03650 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJD5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. http://togogenome.org/gene/1432656:X802_RS00010 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHM0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase IV family.|||Binds 1 Fe(2+) ion per subunit.|||Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.|||Homodimer. http://togogenome.org/gene/1432656:X802_RS09745 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMG9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS05355 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKB2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase small subunit family.|||Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/1432656:X802_RS05370 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKD8 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/1432656:X802_RS02745 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIY9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1432656:X802_RS08950 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM13 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS07210 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL99 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/1432656:X802_RS01220 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI99 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/1432656:X802_RS10530 ^@ http://purl.uniprot.org/uniprot/A0A0X1KN09 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/1432656:X802_RS01735 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIJ7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.|||Binds 1 Mn(2+) ion per subunit.|||Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS01900 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIJ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the OMP decarboxylase family. Type 1 subfamily.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).|||Homodimer. http://togogenome.org/gene/1432656:X802_RS05645 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKH2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS04180 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJR5 ^@ Similarity ^@ Belongs to the MoaD family. http://togogenome.org/gene/1432656:X802_RS07200 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL76 ^@ Function|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro. http://togogenome.org/gene/1432656:X802_RS03180 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS01565 ^@ http://purl.uniprot.org/uniprot/A0A0X1KID5 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the SMC family. RAD50 subfamily.|||Binds 1 zinc ion per homodimer.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.|||The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer. http://togogenome.org/gene/1432656:X802_RS06860 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL31 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/1432656:X802_RS02370 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIT2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS01435 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIC1 ^@ Function|||Similarity|||Subunit ^@ Associates with stalled 50S ribosomal subunits.|||Belongs to the NEMF family.|||Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation. http://togogenome.org/gene/1432656:X802_RS06075 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/1432656:X802_RS09720 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMF7 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/1432656:X802_RS07930 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLJ0 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/1432656:X802_RS01910 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIJ9 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/1432656:X802_RS10200 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMM5 ^@ Similarity ^@ Belongs to the aspartate/glutamate racemases family. http://togogenome.org/gene/1432656:X802_RS10355 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMS6 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. http://togogenome.org/gene/1432656:X802_RS10385 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS04985 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK51 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/1432656:X802_RS03630 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJC9 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/1432656:X802_RS09150 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM67 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1432656:X802_RS09230 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM91 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/1432656:X802_RS02390 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIV5 ^@ Similarity|||Subunit ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Homohexamer. http://togogenome.org/gene/1432656:X802_RS05870 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKI0 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/1432656:X802_RS06040 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKK8 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. UPF0219 family. http://togogenome.org/gene/1432656:X802_RS03270 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ58 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. http://togogenome.org/gene/1432656:X802_RS06105 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKK9 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/1432656:X802_RS06110 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS03110 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ60 ^@ Similarity ^@ Belongs to the complex I 24 kDa subunit family. http://togogenome.org/gene/1432656:X802_RS04460 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJS7 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family.|||Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. http://togogenome.org/gene/1432656:X802_RS03105 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ65 ^@ Similarity ^@ Belongs to the complex I 51 kDa subunit family. http://togogenome.org/gene/1432656:X802_RS00275 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHS1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1432656:X802_RS05090 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK55 ^@ Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Toxic component of a toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/1432656:X802_RS09540 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMC8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the rubredoxin family.|||Binds 1 Fe(3+) ion per subunit.|||Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule. http://togogenome.org/gene/1432656:X802_RS10465 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMV3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.|||Belongs to the AAA ATPase family.|||Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.|||Cytoplasm|||Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets. http://togogenome.org/gene/1432656:X802_RS03480 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJA0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS05655 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKE8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS02315 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/1432656:X802_RS08320 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLP7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeosine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs. http://togogenome.org/gene/1432656:X802_RS02970 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ06 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1432656:X802_RS05635 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKD5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS04890 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK09 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1432656:X802_RS05360 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK98 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. http://togogenome.org/gene/1432656:X802_RS01210 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI84 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/1432656:X802_RS00565 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHX5 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/1432656:X802_RS06975 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL34 ^@ Similarity ^@ Belongs to the UPF0146 family. http://togogenome.org/gene/1432656:X802_RS08485 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLV5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS01705 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal histone HMF family.|||Chromosome|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS06170 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKR5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/1432656:X802_RS04340 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJT3 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/1432656:X802_RS01040 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 'phage' integrase family. XerA subfamily.|||Cytoplasm|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. http://togogenome.org/gene/1432656:X802_RS05440 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKB3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/1432656:X802_RS02295 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIU2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/1432656:X802_RS01385 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIB1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. N-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/1432656:X802_RS08680 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLW3 ^@ Similarity ^@ Belongs to the peptidase C56 family. http://togogenome.org/gene/1432656:X802_RS07050 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL36 ^@ Similarity ^@ Belongs to the organic radical-activating enzymes family. http://togogenome.org/gene/1432656:X802_RS05375 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKB4 ^@ Similarity ^@ Belongs to the CutA family. http://togogenome.org/gene/1432656:X802_RS02055 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIN9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/1432656:X802_RS09765 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMF5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/1432656:X802_RS07355 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLA9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS08750 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM04 ^@ Similarity ^@ Belongs to the NodU/CmcH family. http://togogenome.org/gene/1432656:X802_RS04445 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJT1 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/1432656:X802_RS08075 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLN5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS08025 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLM5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS07365 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL92 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1432656:X802_RS00865 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI18 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS08745 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/1432656:X802_RS03445 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ85 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MobA family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.|||Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. http://togogenome.org/gene/1432656:X802_RS05910 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKI7 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/1432656:X802_RS01300 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI85 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL20 family.|||Part of the 50S ribosomal subunit. Binds 23S rRNA. http://togogenome.org/gene/1432656:X802_RS00485 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Archaeal flagellum|||Belongs to the archaeal flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella. http://togogenome.org/gene/1432656:X802_RS02140 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIN8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS07205 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL63 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/1432656:X802_RS09355 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM95 ^@ Function|||Similarity ^@ Belongs to the TFIIB family.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/1432656:X802_RS01145 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI65 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta-RFA-P synthase family.|||Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).|||Homodimer. http://togogenome.org/gene/1432656:X802_RS05475 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKC6 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS02890 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ13 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS03225 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ74 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS08140 ^@ http://purl.uniprot.org/uniprot/A0A0X1KNB6 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/1432656:X802_RS10450 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMY5 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/1432656:X802_RS03610 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJG1 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/1432656:X802_RS06360 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKQ7 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/1432656:X802_RS05225 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK97 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/1432656:X802_RS05265 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGMT family.|||Cytoplasm|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. http://togogenome.org/gene/1432656:X802_RS03195 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ56 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/1432656:X802_RS03120 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ73 ^@ Cofactor ^@ Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/1432656:X802_RS09535 ^@ http://purl.uniprot.org/uniprot/A0A0X1KME4 ^@ Similarity ^@ Belongs to the desulfoferrodoxin family. http://togogenome.org/gene/1432656:X802_RS01875 ^@ http://purl.uniprot.org/uniprot/A0A0X1KII2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS01290 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI89 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.|||In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.|||In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.|||Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.|||Monomer.|||This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures. http://togogenome.org/gene/1432656:X802_RS09835 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMG4 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/1432656:X802_RS02200 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIQ8 ^@ Similarity ^@ Belongs to the ParA family. MinD subfamily. http://togogenome.org/gene/1432656:X802_RS03470 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ87 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS04515 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJY0 ^@ Function|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/1432656:X802_RS03420 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ75 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/1432656:X802_RS05220 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK85 ^@ Similarity ^@ Belongs to the malic enzymes family. http://togogenome.org/gene/1432656:X802_RS04435 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJW0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal DNA polymerase II family.|||Heterodimer of a large subunit and a small subunit.|||Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. http://togogenome.org/gene/1432656:X802_RS01175 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI60 ^@ Caution|||Function|||Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS06580 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclic 2,3-diphosphoglycerate synthetase family.|||Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS02985 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ42 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/1432656:X802_RS05555 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS09340 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM79 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||May be involved in maturation of the 30S ribosomal subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1432656:X802_RS03900 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJK7 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/1432656:X802_RS06280 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKT2 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS31 family.|||Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1432656:X802_RS04525 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJU5 ^@ Function|||Similarity ^@ Belongs to the V-ATPase F subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/1432656:X802_RS05835 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKH0 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A single active site specifically recognizes both ATP and CTP and is responsible for their addition.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.|||Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.|||Homodimer. http://togogenome.org/gene/1432656:X802_RS10300 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMT0 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/1432656:X802_RS09285 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM69 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LamB/PxpA family.|||Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.|||Forms a complex composed of PxpA, PxpB and PxpC. http://togogenome.org/gene/1432656:X802_RS07510 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLD9 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/1432656:X802_RS04770 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK14 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/1432656:X802_RS02080 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIN0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS02875 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ12 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/1432656:X802_RS10020 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mediates influx of magnesium ions.|||Membrane http://togogenome.org/gene/1432656:X802_RS01270 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI78 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/1432656:X802_RS04495 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJV2 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/1432656:X802_RS04465 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NucS endonuclease family.|||Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS03605 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJE3 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/1432656:X802_RS08740 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLZ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1432656:X802_RS05640 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKD6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS06385 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKV4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/1432656:X802_RS04085 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJN4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS03265 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ72 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp41 subfamily.|||Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS01525 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIF3 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/1432656:X802_RS03070 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ35 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1432656:X802_RS05140 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK75 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/1432656:X802_RS09980 ^@ http://purl.uniprot.org/uniprot/A0A0X1KML9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS05810 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKH1 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/1432656:X802_RS00355 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHS9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS08035 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLN0 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1432656:X802_RS08280 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS10425 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMY3 ^@ Similarity ^@ Belongs to the UPF0179 family. http://togogenome.org/gene/1432656:X802_RS08920 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM06 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS00400 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHT7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. http://togogenome.org/gene/1432656:X802_RS00235 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHR2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the carbohydrate kinase PfkC family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS04235 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJR4 ^@ Similarity ^@ Belongs to the UPF0147 family. http://togogenome.org/gene/1432656:X802_RS03005 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ25 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/1432656:X802_RS09930 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMM6 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/1432656:X802_RS07430 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL98 ^@ Similarity ^@ Belongs to the UPF0128 family. http://togogenome.org/gene/1432656:X802_RS02485 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIX1 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/1432656:X802_RS02285 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIT7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS08560 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLT9 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/1432656:X802_RS07915 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLK4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/1432656:X802_RS08475 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLU1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS02535 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUA5 family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/1432656:X802_RS01835 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIJ6 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/1432656:X802_RS01205 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI63 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. TrmY family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs. http://togogenome.org/gene/1432656:X802_RS08300 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.|||Membrane http://togogenome.org/gene/1432656:X802_RS03590 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJD3 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/1432656:X802_RS10275 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMS2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS01345 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIA2 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/1432656:X802_RS00475 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Archaeal flagellum|||Belongs to the archaeal flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella. http://togogenome.org/gene/1432656:X802_RS02400 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIW3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS06565 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS02935 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ32 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/1432656:X802_RS05985 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKK1 ^@ Function|||Similarity ^@ Belongs to the TBP family.|||General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. http://togogenome.org/gene/1432656:X802_RS09135 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM83 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS02050 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIL3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL24 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14. http://togogenome.org/gene/1432656:X802_RS05495 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKD1 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase. http://togogenome.org/gene/1432656:X802_RS10135 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMP0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcA family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||nucleolus http://togogenome.org/gene/1432656:X802_RS07605 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLD6 ^@ Similarity ^@ Belongs to the SfsA family. http://togogenome.org/gene/1432656:X802_RS07095 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL60 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/1432656:X802_RS02995 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ17 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/1432656:X802_RS06825 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL14 ^@ Similarity ^@ In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/1432656:X802_RS09090 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM64 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin alpha subunit family.|||Belongs to the prefoldin subunit alpha family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/1432656:X802_RS03280 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ88 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/1432656:X802_RS07850 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLH3 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the GatB/GatE family. GatE subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/1432656:X802_RS00300 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHS0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/1432656:X802_RS06980 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL42 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS05335 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK93 ^@ Similarity ^@ Belongs to the UPF0216 family. http://togogenome.org/gene/1432656:X802_RS02410 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIR6 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/1432656:X802_RS03875 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJK3 ^@ Similarity ^@ Belongs to the UPF0252 family. http://togogenome.org/gene/1432656:X802_RS08020 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLQ4 ^@ Similarity ^@ Belongs to the UPF0200 family. http://togogenome.org/gene/1432656:X802_RS07100 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL51 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the YjjX NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/1432656:X802_RS00595 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHX1 ^@ Function|||Similarity ^@ Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/1432656:X802_RS05125 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK58 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcL subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/1432656:X802_RS08405 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLS4 ^@ Cofactor|||Function|||Subunit ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/1432656:X802_RS07110 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL78 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS02440 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS08315 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLQ6 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Potential transporter for phosphate. http://togogenome.org/gene/1432656:X802_RS03425 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJC3 ^@ Similarity ^@ Belongs to the UPF0175 family. http://togogenome.org/gene/1432656:X802_RS05075 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK78 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family. RadB subfamily.|||Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. http://togogenome.org/gene/1432656:X802_RS06995 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1432656:X802_RS05950 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKK5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS08760 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLY1 ^@ Similarity ^@ Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/1432656:X802_RS03705 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJG9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell membrane|||Involved in protein export.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the protein translocation apparatus. Forms a complex with SecF. http://togogenome.org/gene/1432656:X802_RS04630 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJV6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/1432656:X802_RS03415 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJA5 ^@ Function|||Similarity ^@ Belongs to the HypA/HybF family.|||Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. http://togogenome.org/gene/1432656:X802_RS01925 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIL1 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the UPF0165 family. http://togogenome.org/gene/1432656:X802_RS00530 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHW6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS04590 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJV5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Forms a Heterooligomeric complex of two stacked eight-membered rings.|||Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. http://togogenome.org/gene/1432656:X802_RS04885 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS01805 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIH2 ^@ Caution|||Function|||Similarity ^@ Belongs to the Nre family.|||Involved in DNA damage repair.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS08615 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLV4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/1432656:X802_RS01855 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GDT1 family.|||Membrane http://togogenome.org/gene/1432656:X802_RS03190 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ82 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/1432656:X802_RS09360 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMC2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA. http://togogenome.org/gene/1432656:X802_RS02945 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ02 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1432656:X802_RS09855 ^@ http://purl.uniprot.org/uniprot/A0A0X1KML2 ^@ Similarity ^@ In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.|||In the central section; belongs to the CRISPR-associated helicase Cas3 family. http://togogenome.org/gene/1432656:X802_RS07835 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLH1 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/1432656:X802_RS06180 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKQ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SPT5 family.|||Belongs to the archaeal Spt5 family.|||Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).|||Stimulates transcription elongation. http://togogenome.org/gene/1432656:X802_RS07665 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLI8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ADP-dependent glucokinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS07795 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLH9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1432656:X802_RS05390 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKA7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvT family.|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/1432656:X802_RS06545 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKV2 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/1432656:X802_RS00255 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHQ8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS01045 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI43 ^@ Function|||Miscellaneous|||Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.|||Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.|||Reaction proceeds via a cis-phosphoenolate intermediate. http://togogenome.org/gene/1432656:X802_RS08820 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Cytoplasm|||Functions by promoting the formation of the first peptide bond. http://togogenome.org/gene/1432656:X802_RS07640 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLH4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-alpha family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/1432656:X802_RS01095 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI54 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS06550 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS07035 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL40 ^@ Similarity ^@ Belongs to the transcriptional regulator TrmB family. http://togogenome.org/gene/1432656:X802_RS04360 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJR6 ^@ Similarity ^@ Belongs to the peptidase S9C family. http://togogenome.org/gene/1432656:X802_RS09185 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM93 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1432656:X802_RS05245 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK70 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/1432656:X802_RS08890 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM11 ^@ Function|||Similarity ^@ Belongs to the deoxyhypusine synthase family.|||Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. http://togogenome.org/gene/1432656:X802_RS04110 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJM0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS06255 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKT5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/1432656:X802_RS00620 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1432656:X802_RS01995 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIM1 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/1432656:X802_RS03250 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ93 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/1432656:X802_RS05885 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKH6 ^@ Function|||Subunit ^@ Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/1432656:X802_RS07895 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLJ6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/1432656:X802_RS07580 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RAD3/XPD subfamily.|||Nucleus http://togogenome.org/gene/1432656:X802_RS02405 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIU0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.|||Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.|||Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1432656:X802_RS07025 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1432656:X802_RS07540 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLB8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/1432656:X802_RS04760 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK17 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/1432656:X802_RS00310 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHS7 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/1432656:X802_RS01155 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS02940 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ21 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1432656:X802_RS10360 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMV5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/1432656:X802_RS01540 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIE3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of glycine to tRNA(Gly).|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS01760 ^@ http://purl.uniprot.org/uniprot/A0A0X1KII4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Cytoplasm|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1432656:X802_RS06350 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKR4 ^@ Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Toxic component of a toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/1432656:X802_RS09630 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMF2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS04510 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJT8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS04165 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJR8 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/1432656:X802_RS06690 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL05 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS03410 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJB7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the transcriptional regulatory CopG/NikR family.|||Binds 1 nickel ion per subunit.|||Transcriptional regulator. http://togogenome.org/gene/1432656:X802_RS02065 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIQ1 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruD family.|||Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. http://togogenome.org/gene/1432656:X802_RS05525 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKE9 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/1432656:X802_RS03710 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJG3 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/1432656:X802_RS01395 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1432656:X802_RS07065 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL44 ^@ Function|||Similarity ^@ Belongs to the UPF0330 family.|||Possibly the antitoxin component of a toxin-antitoxin (TA) module. http://togogenome.org/gene/1432656:X802_RS03260 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJA6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp42 subfamily.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. http://togogenome.org/gene/1432656:X802_RS04330 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJS2 ^@ Similarity ^@ Belongs to the carbamate kinase family. http://togogenome.org/gene/1432656:X802_RS07230 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS01100 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI48 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS07785 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm http://togogenome.org/gene/1432656:X802_RS07225 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS07545 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLD4 ^@ Similarity ^@ Belongs to the UPF0284 family. http://togogenome.org/gene/1432656:X802_RS05240 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK88 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/1432656:X802_RS06270 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKP6 ^@ Function|||Similarity ^@ Belongs to the GTP-dependent DPCK family.|||Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). http://togogenome.org/gene/1432656:X802_RS01470 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIE4 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/1432656:X802_RS09105 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM49 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/1432656:X802_RS09865 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMJ3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/1432656:X802_RS09130 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM55 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS05855 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKI4 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase class-2 family.|||Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. http://togogenome.org/gene/1432656:X802_RS07615 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLH8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1432656:X802_RS06725 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm|||Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.|||Heterodimer of two subunits, one of which binds GTP. http://togogenome.org/gene/1432656:X802_RS02950 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ43 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/1432656:X802_RS00360 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHU1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS08815 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS02595 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIX0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/1432656:X802_RS06425 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKR7 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/1432656:X802_RS07440 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLA6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidine kinase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/1432656:X802_RS01250 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI75 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.|||Cell membrane|||Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane|||Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function. http://togogenome.org/gene/1432656:X802_RS04520 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJV0 ^@ Function|||Similarity ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/1432656:X802_RS05630 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKF8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS01505 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1432656:X802_RS02805 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ26 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/1432656:X802_RS01050 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI37 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/1432656:X802_RS04440 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJU2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA polymerase delta/II small subunit family.|||Heterodimer of a large subunit and a small subunit.|||Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. http://togogenome.org/gene/1432656:X802_RS10260 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMN3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/1432656:X802_RS04130 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJQ7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS02955 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ15 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/1432656:X802_RS01775 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIH4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/1432656:X802_RS06685 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKW9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS01745 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIG3 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/1432656:X802_RS06355 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKV3 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the UPF0165 family. http://togogenome.org/gene/1432656:X802_RS09690 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMH3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the GTP cyclohydrolase II family.|||Binds 1 zinc ion per subunit.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.|||In the N-terminal section; belongs to the DHBP synthase family. http://togogenome.org/gene/1432656:X802_RS00610 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHY1 ^@ Similarity ^@ Belongs to the transcriptional regulator TrmB family. http://togogenome.org/gene/1432656:X802_RS03205 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ99 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/1432656:X802_RS07445 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS03040 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ41 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/1432656:X802_RS05595 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKC7 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family. http://togogenome.org/gene/1432656:X802_RS01860 ^@ http://purl.uniprot.org/uniprot/A0A0X1KII9 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1432656:X802_RS03670 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJF2 ^@ Cofactor|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/1432656:X802_RS07115 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL46 ^@ Function|||Similarity|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.|||Homodimer or homotetramer. http://togogenome.org/gene/1432656:X802_RS02650 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIY0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL40 family. http://togogenome.org/gene/1432656:X802_RS07010 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL21 ^@ Similarity ^@ Belongs to the transcriptional regulator TrmB family. http://togogenome.org/gene/1432656:X802_RS06635 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKV8 ^@ Similarity ^@ Belongs to the complex I 49 kDa subunit family. http://togogenome.org/gene/1432656:X802_RS03010 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ69 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29. http://togogenome.org/gene/1432656:X802_RS09815 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMH8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/1432656:X802_RS01780 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NusA family.|||Cytoplasm|||Participates in transcription termination. http://togogenome.org/gene/1432656:X802_RS08635 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLX2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal-type GPI family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1432656:X802_RS08080 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLM4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/1432656:X802_RS05920 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS00365 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHT2 ^@ Function ^@ Probably involved in the biogenesis of the ribosome. http://togogenome.org/gene/1432656:X802_RS02555 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIW1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/1432656:X802_RS00295 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHR7 ^@ Similarity ^@ Belongs to the UPF0440 family. http://togogenome.org/gene/1432656:X802_RS01305 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI95 ^@ Function|||Similarity ^@ Belongs to the eIF-6 family.|||Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. http://togogenome.org/gene/1432656:X802_RS10155 ^@ http://purl.uniprot.org/uniprot/A0A0X1KML8 ^@ Similarity ^@ Belongs to the UPF0212 family. http://togogenome.org/gene/1432656:X802_RS00405 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHU2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/1432656:X802_RS07655 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLE6 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/1432656:X802_RS02145 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIP9 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/1432656:X802_RS01510 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIE2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the isopentenyl phosphate kinase family.|||Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.|||Homodimer. http://togogenome.org/gene/1432656:X802_RS06125 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKN3 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/1432656:X802_RS04255 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJS3 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/1432656:X802_RS02905 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ05 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1432656:X802_RS06380 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKR3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/1432656:X802_RS04300 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJT5 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the FBP aldolase/phosphatase family.|||Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).|||Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.|||Homooctamer; dimer of tetramers. http://togogenome.org/gene/1432656:X802_RS02795 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ16 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.|||Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/1432656:X802_RS00540 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHY3 ^@ Similarity ^@ Belongs to the RuvB family. http://togogenome.org/gene/1432656:X802_RS04530 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJY3 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. http://togogenome.org/gene/1432656:X802_RS01595 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIG1 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.|||Belongs to the RuBisCO large chain family. Type III subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.|||Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits. http://togogenome.org/gene/1432656:X802_RS06185 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKP0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/1432656:X802_RS06805 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKY4 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1432656:X802_RS07145 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL74 ^@ Function|||Similarity ^@ Belongs to the AdoMet synthase 2 family.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/1432656:X802_RS06205 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKQ0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Catalyzes the deamination of dCTP to dUTP.|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS00615 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHX9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS02820 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS07900 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLI5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.|||Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure. http://togogenome.org/gene/1432656:X802_RS10110 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMM1 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1432656:X802_RS06050 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKP3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.|||Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. http://togogenome.org/gene/1432656:X802_RS04855 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK08 ^@ Function|||Similarity|||Subunit ^@ Belongs to the diphthine synthase family.|||Homodimer.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/1432656:X802_RS08930 ^@ http://purl.uniprot.org/uniprot/A0A0X1KM16 ^@ Similarity ^@ Belongs to the protein kinase superfamily. BUD32 family. http://togogenome.org/gene/1432656:X802_RS04820 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK23 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS09705 ^@ http://purl.uniprot.org/uniprot/A0A0X1KMF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/1432656:X802_RS02070 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTH2 family.|||Cytoplasm|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/1432656:X802_RS02965 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ27 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges. http://togogenome.org/gene/1432656:X802_RS08250 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLN1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/1432656:X802_RS00385 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHU7 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/1432656:X802_RS07000 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL27 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 1 family. http://togogenome.org/gene/1432656:X802_RS06675 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKY0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS06275 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKN9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/1432656:X802_RS01230 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI67 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1432656:X802_RS02670 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/1432656:X802_RS01225 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI91 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/1432656:X802_RS02900 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ30 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/1432656:X802_RS03460 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJC8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS05840 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKF4 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/1432656:X802_RS02930 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ28 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/1432656:X802_RS02990 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ33 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1432656:X802_RS06870 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL22 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/1432656:X802_RS01120 ^@ http://purl.uniprot.org/uniprot/A0A0X1KI70 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1432656:X802_RS02960 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ57 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Located at the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1432656:X802_RS05185 ^@ http://purl.uniprot.org/uniprot/A0A0X1KK66 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/1432656:X802_RS00335 ^@ http://purl.uniprot.org/uniprot/A0A0X1KHT5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS07370 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLD2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobD/CbiB family.|||Cell membrane|||Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1432656:X802_RS01450 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIB4 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent DNA ligase family.|||DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. http://togogenome.org/gene/1432656:X802_RS08830 ^@ http://purl.uniprot.org/uniprot/A0A0X1KLZ3 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.|||Has ATPase and non-specific DNA-binding activities. http://togogenome.org/gene/1432656:X802_RS02215 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIP6 ^@ Function|||Similarity ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.|||Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. http://togogenome.org/gene/1432656:X802_RS04145 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJP2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1432656:X802_RS07020 ^@ http://purl.uniprot.org/uniprot/A0A0X1KL65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1432656:X802_RS02915 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJ19 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Part of the 30S ribosomal subunit. Contacts protein S4.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1432656:X802_RS02750 ^@ http://purl.uniprot.org/uniprot/A0A0X1KIW8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1432656:X802_RS06410 ^@ http://purl.uniprot.org/uniprot/A0A0X1KKS3 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/1432656:X802_RS03785 ^@ http://purl.uniprot.org/uniprot/A0A0X1KJG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S16 family.|||Membrane