http://togogenome.org/gene/1705394:SP60_RS07855 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXN2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/1705394:SP60_RS04100 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEJ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/1705394:SP60_RS06415 ^@ http://purl.uniprot.org/uniprot/A0A0M4PL81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS06125 ^@ http://purl.uniprot.org/uniprot/A0A0M4PL77 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).|||Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1. http://togogenome.org/gene/1705394:SP60_RS06740 ^@ http://purl.uniprot.org/uniprot/A0A0M5LJD8 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the RuBisCO large chain family. Type I subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Heterohexadecamer of 8 large chains and 8 small chains.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.|||The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric 'cap' on each end of the 'barrel'. http://togogenome.org/gene/1705394:SP60_RS05580 ^@ http://purl.uniprot.org/uniprot/A0A0M4PNH4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/1705394:SP60_RS07850 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUK9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS01520 ^@ http://purl.uniprot.org/uniprot/A0A0M4NSY9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/1705394:SP60_RS08330 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWH3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS06640 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXS5 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/1705394:SP60_RS05025 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHB0 ^@ Similarity ^@ Belongs to the site-specific recombinase resolvase family. http://togogenome.org/gene/1705394:SP60_RS01440 ^@ http://purl.uniprot.org/uniprot/A0A0M4PM76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.|||Cytoplasm|||Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. http://togogenome.org/gene/1705394:SP60_RS01060 ^@ http://purl.uniprot.org/uniprot/A0A0M4NSV4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspG family.|||Binds 1 [4Fe-4S] cluster.|||Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. http://togogenome.org/gene/1705394:SP60_RS06205 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJH3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ClpA/ClpB family.|||Cytoplasm|||Homohexamer. The oligomerization is ATP-dependent.|||Homohexamer; The oligomerization is ATP-dependent.|||Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. http://togogenome.org/gene/1705394:SP60_RS04675 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEU5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS01135 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTR7 ^@ Similarity ^@ Belongs to the asparagine synthetase family. http://togogenome.org/gene/1705394:SP60_RS05200 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurF subfamily.|||Cytoplasm|||Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. http://togogenome.org/gene/1705394:SP60_RS07965 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUL3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LipB family.|||Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.|||Cytoplasm|||In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. http://togogenome.org/gene/1705394:SP60_RS08130 ^@ http://purl.uniprot.org/uniprot/A0A0M4PPC5 ^@ Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family. http://togogenome.org/gene/1705394:SP60_RS06720 ^@ http://purl.uniprot.org/uniprot/A0A0M4PL98 ^@ Function|||Similarity ^@ Belongs to the RuBisCO large chain family. Type II subfamily.|||RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site. http://togogenome.org/gene/1705394:SP60_RS01160 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHW6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1705394:SP60_RS05775 ^@ http://purl.uniprot.org/uniprot/A0A0M4PNK1 ^@ Function|||Similarity ^@ Belongs to the precorrin methyltransferase family.|||In the C-terminal section; belongs to the precorrin methyltransferase family.|||In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.|||Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. http://togogenome.org/gene/1705394:SP60_RS05790 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUD9 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/1705394:SP60_RS04005 ^@ http://purl.uniprot.org/uniprot/A0A0M5LHI5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS00525 ^@ http://purl.uniprot.org/uniprot/A0A0M4PJI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.|||Cell membrane|||Self-interacts. Interacts with FtsZ. http://togogenome.org/gene/1705394:SP60_RS04295 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU23 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. http://togogenome.org/gene/1705394:SP60_RS00650 ^@ http://purl.uniprot.org/uniprot/A0A0M4NVF7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Homotetramer.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/1705394:SP60_RS03650 ^@ http://purl.uniprot.org/uniprot/A0A0M4NIM0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccD/PCCB family.|||Binds 1 zinc ion per subunit.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS08115 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUF2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the selenophosphate synthase 1 family. Class I subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Homodimer.|||Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/1705394:SP60_RS06120 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU87 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS04225 ^@ http://purl.uniprot.org/uniprot/A0A0M4NIS9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS03865 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU69 ^@ Function ^@ This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/1705394:SP60_RS05130 ^@ http://purl.uniprot.org/uniprot/A0A0M5LES3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/1705394:SP60_RS00530 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTW2 ^@ Caution|||Function|||Similarity ^@ Belongs to the Dus family. DusA subfamily.|||Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS06220 ^@ http://purl.uniprot.org/uniprot/A0A0M4PNQ9 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/1705394:SP60_RS01170 ^@ http://purl.uniprot.org/uniprot/A0A0M4NW88 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/1705394:SP60_RS00190 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHK0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aerobic coproporphyrinogen-III oxidase family.|||Cytoplasm|||Homodimer.|||Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. http://togogenome.org/gene/1705394:SP60_RS01890 ^@ http://purl.uniprot.org/uniprot/A0A0M4P872 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerD subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/1705394:SP60_RS03255 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEW8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS03450 ^@ http://purl.uniprot.org/uniprot/A0A0M4NTG1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the trans-sulfuration enzymes family. MetZ subfamily.|||Catalyzes the formation of L-homocysteine from O-succinyl-L-homoserine (OSHS) and hydrogen sulfide.|||Homotetramer. http://togogenome.org/gene/1705394:SP60_RS03920 ^@ http://purl.uniprot.org/uniprot/A0A0M4P8V7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the BPG-independent phosphoglycerate mutase family.|||Binds 2 manganese ions per subunit.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.|||Monomer. http://togogenome.org/gene/1705394:SP60_RS01480 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTZ2 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/1705394:SP60_RS06890 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXB9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NapD family.|||Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.|||Cytoplasm|||Interacts with the cytoplasmic NapA precursor. http://togogenome.org/gene/1705394:SP60_RS07930 ^@ http://purl.uniprot.org/uniprot/A0A0M4NI77 ^@ Function|||Similarity ^@ Belongs to the Ap4A hydrolase family.|||Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP. http://togogenome.org/gene/1705394:SP60_RS04640 ^@ http://purl.uniprot.org/uniprot/A0A0M4P944 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-allosteric. http://togogenome.org/gene/1705394:SP60_RS02570 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU30 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/1705394:SP60_RS04390 ^@ http://purl.uniprot.org/uniprot/A0A0M4PN12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmI family.|||Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS04180 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU19 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/1705394:SP60_RS01005 ^@ http://purl.uniprot.org/uniprot/A0A0M4P7X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS02015 ^@ http://purl.uniprot.org/uniprot/A0A0M4NGF5 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/1705394:SP60_RS06215 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEU4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS06845 ^@ http://purl.uniprot.org/uniprot/A0A0M4P9T7 ^@ Similarity|||Subunit ^@ Belongs to the MoaE family.|||Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis. http://togogenome.org/gene/1705394:SP60_RS07005 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUB4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS07915 ^@ http://purl.uniprot.org/uniprot/A0A0M4PP99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS01700 ^@ http://purl.uniprot.org/uniprot/A0A0M4NI21 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS01430 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTZ0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1705394:SP60_RS00050 ^@ http://purl.uniprot.org/uniprot/A0A0M5LIW7 ^@ Caution|||Function|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. http://togogenome.org/gene/1705394:SP60_RS02645 ^@ http://purl.uniprot.org/uniprot/A0A0M4PMK5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/1705394:SP60_RS01615 ^@ http://purl.uniprot.org/uniprot/A0A0M4P837 ^@ Similarity ^@ Belongs to the YciI family. http://togogenome.org/gene/1705394:SP60_RS04845 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWQ5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endoribonuclease YbeY family.|||Binds 1 zinc ion.|||Cytoplasm|||Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. http://togogenome.org/gene/1705394:SP60_RS05850 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS06585 ^@ http://purl.uniprot.org/uniprot/A0A0M4PNV3 ^@ Similarity ^@ Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. http://togogenome.org/gene/1705394:SP60_RS07675 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEX3 ^@ Similarity ^@ Belongs to the HesB/IscA family. http://togogenome.org/gene/1705394:SP60_RS02960 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEH7 ^@ Function|||Similarity ^@ Belongs to the helicase family. RecG subfamily.|||Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). http://togogenome.org/gene/1705394:SP60_RS05375 ^@ http://purl.uniprot.org/uniprot/A0A0M4NTZ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1705394:SP60_RS04320 ^@ http://purl.uniprot.org/uniprot/A0A0M4PN04 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.|||Cell membrane|||Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane|||Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function. http://togogenome.org/gene/1705394:SP60_RS01130 ^@ http://purl.uniprot.org/uniprot/A0A0M4NG57 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase H family.|||Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Monomer. http://togogenome.org/gene/1705394:SP60_RS07635 ^@ http://purl.uniprot.org/uniprot/A0A0M4NI45 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/1705394:SP60_RS07105 ^@ http://purl.uniprot.org/uniprot/A0A0M5LJE7 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/1705394:SP60_RS01725 ^@ http://purl.uniprot.org/uniprot/A0A0M4NVQ7 ^@ Function|||Similarity ^@ Belongs to the LpxK family.|||Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). http://togogenome.org/gene/1705394:SP60_RS02545 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEG7 ^@ Function|||Similarity ^@ Belongs to the glucose-1-phosphate thymidylyltransferase family.|||Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. http://togogenome.org/gene/1705394:SP60_RS04365 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKM4 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/1705394:SP60_RS03780 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEI0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase gamma chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. http://togogenome.org/gene/1705394:SP60_RS07820 ^@ http://purl.uniprot.org/uniprot/A0A0M4PLM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.|||Membrane http://togogenome.org/gene/1705394:SP60_RS05545 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU68 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS06645 ^@ http://purl.uniprot.org/uniprot/A0A0M5LET2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvC family.|||Binds 2 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/1705394:SP60_RS07900 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thioester dehydratase family. FabZ subfamily.|||Cytoplasm|||Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. http://togogenome.org/gene/1705394:SP60_RS04750 ^@ http://purl.uniprot.org/uniprot/A0A0M4NX78 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/1705394:SP60_RS02000 ^@ http://purl.uniprot.org/uniprot/A0A0M4PMD9 ^@ Similarity ^@ Belongs to the polysaccharide synthase family. http://togogenome.org/gene/1705394:SP60_RS05810 ^@ http://purl.uniprot.org/uniprot/A0A0M4P9H2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/1705394:SP60_RS01860 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTU1 ^@ Similarity ^@ Belongs to the DsrF/TusC family. http://togogenome.org/gene/1705394:SP60_RS03660 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEP2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS00540 ^@ http://purl.uniprot.org/uniprot/A0A0M4NW33 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/1705394:SP60_RS01210 ^@ http://purl.uniprot.org/uniprot/A0A0M4P7Z8 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. RsmD family.|||Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle. http://togogenome.org/gene/1705394:SP60_RS03195 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWS4 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/1705394:SP60_RS05720 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWY8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.|||Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS02650 ^@ http://purl.uniprot.org/uniprot/A0A0M4NW00 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/1705394:SP60_RS04250 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWI1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1705394:SP60_RS00570 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUF6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the pyridoxamine 5'-phosphate oxidase family.|||Binds 1 FMN per subunit.|||Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS06560 ^@ http://purl.uniprot.org/uniprot/A0A0M4PL83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS01845 ^@ http://purl.uniprot.org/uniprot/A0A0M4NI36 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS02985 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEG8 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. http://togogenome.org/gene/1705394:SP60_RS04665 ^@ http://purl.uniprot.org/uniprot/A0A0M4NX71 ^@ Similarity ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. http://togogenome.org/gene/1705394:SP60_RS01090 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHV9 ^@ Similarity ^@ Belongs to the ribosome association toxin RatA family. http://togogenome.org/gene/1705394:SP60_RS05240 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUB9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS00765 ^@ http://purl.uniprot.org/uniprot/A0A0M5LE91 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the thiamine-monophosphate kinase family.|||Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. http://togogenome.org/gene/1705394:SP60_RS00295 ^@ http://purl.uniprot.org/uniprot/A0A0M4NVA9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the Rho family.|||Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.|||Homohexamer. The homohexamer assembles into an open ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS06405 ^@ http://purl.uniprot.org/uniprot/A0A0M5LL84 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the D-alanine--D-alanine ligase family.|||Binds 2 magnesium or manganese ions per subunit.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS06015 ^@ http://purl.uniprot.org/uniprot/A0A0M5LJC0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS06700 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHU2 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/1705394:SP60_RS06725 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJN4 ^@ Similarity ^@ Belongs to the CbbQ/NirQ/NorQ/GpvN family. http://togogenome.org/gene/1705394:SP60_RS03285 ^@ http://purl.uniprot.org/uniprot/A0A0M4PMR6 ^@ Cofactor|||Similarity ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit. http://togogenome.org/gene/1705394:SP60_RS05235 ^@ http://purl.uniprot.org/uniprot/A0A0M4PNC9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/1705394:SP60_RS07480 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXJ2 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/1705394:SP60_RS04065 ^@ http://purl.uniprot.org/uniprot/A0A0M4P8X4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dethiobiotin synthetase family.|||Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS00225 ^@ http://purl.uniprot.org/uniprot/A0A0M4NSL6 ^@ Function|||Similarity ^@ Belongs to the RmuC family.|||Involved in DNA recombination. http://togogenome.org/gene/1705394:SP60_RS07415 ^@ http://purl.uniprot.org/uniprot/A0A0M4NUK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/1705394:SP60_RS08120 ^@ http://purl.uniprot.org/uniprot/A0A0M4NY86 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SelU family.|||Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.|||Monomer. http://togogenome.org/gene/1705394:SP60_RS06090 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUE9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS08020 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUL5 ^@ Function|||Similarity ^@ Belongs to the band 7/mec-2 family. HflC subfamily.|||HflC and HflK could regulate a protease. http://togogenome.org/gene/1705394:SP60_RS01205 ^@ http://purl.uniprot.org/uniprot/A0A0M4NG65 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/1705394:SP60_RS05980 ^@ http://purl.uniprot.org/uniprot/A0A0M4PL59 ^@ Similarity ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. http://togogenome.org/gene/1705394:SP60_RS01925 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWF5 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS04045 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU75 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/1705394:SP60_RS03745 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEI9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.|||Cell membrane|||Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. http://togogenome.org/gene/1705394:SP60_RS01985 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWG1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS03665 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU01 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.|||Binds 1 zinc ion per subunit.|||Binds the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1705394:SP60_RS05380 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHF1 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/1705394:SP60_RS03425 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWU7 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS05575 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEM0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose 5-phosphate isomerase family.|||Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS05435 ^@ http://purl.uniprot.org/uniprot/A0A0M4NU04 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/1705394:SP60_RS04040 ^@ http://purl.uniprot.org/uniprot/A0A0M4PMW9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/1705394:SP60_RS07145 ^@ http://purl.uniprot.org/uniprot/A0A0M4P9W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS03115 ^@ http://purl.uniprot.org/uniprot/A0A0M4PLU5 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/1705394:SP60_RS06005 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXK5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/1705394:SP60_RS03575 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU58 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/1705394:SP60_RS05140 ^@ http://purl.uniprot.org/uniprot/A0A0M4PNC1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation.|||May be beta-lysylated on the epsilon-amino group of Lys-34 by the combined action of EpmA and EpmB, and then hydroxylated on the C5 position of the same residue by EpmC (if this protein is present). Lysylation is critical for the stimulatory effect of EF-P on peptide-bond formation. The lysylation moiety may extend toward the peptidyltransferase center and stabilize the terminal 3-CCA end of the tRNA. Hydroxylation of the C5 position on Lys-34 may allow additional potential stabilizing hydrogen-bond interactions with the P-tRNA. http://togogenome.org/gene/1705394:SP60_RS05095 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHB9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.|||Binds 2 [4Fe-4S] clusters per subunit.|||Cell inner membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/1705394:SP60_RS05425 ^@ http://purl.uniprot.org/uniprot/A0A0M4PNF6 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/1705394:SP60_RS00035 ^@ http://purl.uniprot.org/uniprot/A0A0M4PJD5 ^@ Function|||Similarity ^@ Belongs to the relA/spoT family.|||In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. http://togogenome.org/gene/1705394:SP60_RS00985 ^@ http://purl.uniprot.org/uniprot/A0A0M4NVI9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/1705394:SP60_RS02655 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTW9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LpxH family.|||Binds 2 Mn(2+) ions per subunit in a binuclear metal center.|||Cell inner membrane|||Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. http://togogenome.org/gene/1705394:SP60_RS05310 ^@ http://purl.uniprot.org/uniprot/A0A0M4NTY5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1705394:SP60_RS07685 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXL6 ^@ Function|||Similarity ^@ Belongs to the heat shock protein 70 family.|||Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. http://togogenome.org/gene/1705394:SP60_RS05645 ^@ http://purl.uniprot.org/uniprot/A0A0M4PNI3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 49 kDa subunit family.|||Cell membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/1705394:SP60_RS05880 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA-PH family.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS01285 ^@ http://purl.uniprot.org/uniprot/A0A0M4NG67 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/1705394:SP60_RS06045 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHM2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1705394:SP60_RS05655 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU72 ^@ Function|||Similarity ^@ Belongs to the complex I 51 kDa subunit family.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. http://togogenome.org/gene/1705394:SP60_RS01535 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTZ4 ^@ Cofactor|||Similarity ^@ Belongs to the PTPS family. QueD subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1705394:SP60_RS06155 ^@ http://purl.uniprot.org/uniprot/A0A0M4NX39 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I fumarase family.|||Catalyzes the reversible hydration of fumarate to (S)-malate.|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS02430 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEQ0 ^@ Similarity ^@ Belongs to the NodU/CmcH family. http://togogenome.org/gene/1705394:SP60_RS03140 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEP1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/1705394:SP60_RS01380 ^@ http://purl.uniprot.org/uniprot/A0A0M4NG78 ^@ Function|||Similarity ^@ Belongs to the NadD family.|||Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). http://togogenome.org/gene/1705394:SP60_RS05075 ^@ http://purl.uniprot.org/uniprot/A0A0M4PNB5 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/1705394:SP60_RS01570 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTT1 ^@ Similarity ^@ Belongs to the nitroreductase family. HadB/RutE subfamily. http://togogenome.org/gene/1705394:SP60_RS03625 ^@ http://purl.uniprot.org/uniprot/A0A0M4NGZ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS05485 ^@ http://purl.uniprot.org/uniprot/A0A0M4PNG6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M17 family.|||Binds 2 manganese ions per subunit.|||Cytoplasm|||Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. http://togogenome.org/gene/1705394:SP60_RS03645 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKE4 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/1705394:SP60_RS05245 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXK5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/1705394:SP60_RS00760 ^@ http://purl.uniprot.org/uniprot/A0A0M4P7U6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DksA family.|||Cytoplasm|||Interacts directly with the RNA polymerase.|||Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. http://togogenome.org/gene/1705394:SP60_RS00890 ^@ http://purl.uniprot.org/uniprot/A0A0M4NVI1 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/1705394:SP60_RS03760 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWC0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the KdsC family.|||Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.|||Homotetramer. http://togogenome.org/gene/1705394:SP60_RS04505 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKN8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. http://togogenome.org/gene/1705394:SP60_RS01885 ^@ http://purl.uniprot.org/uniprot/A0A0M4NGD7 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/1705394:SP60_RS01530 ^@ http://purl.uniprot.org/uniprot/A0A0M4P830 ^@ Function|||Similarity ^@ Belongs to the GTP cyclohydrolase IV family.|||Converts GTP to 7,8-dihydroneopterin triphosphate. http://togogenome.org/gene/1705394:SP60_RS02580 ^@ http://purl.uniprot.org/uniprot/A0A0M4PMJ7 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1705394:SP60_RS03095 ^@ http://purl.uniprot.org/uniprot/A0A0M4P8K9 ^@ Function|||Similarity ^@ Belongs to the DHNA family.|||Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. http://togogenome.org/gene/1705394:SP60_RS05670 ^@ http://purl.uniprot.org/uniprot/A0A0M4P9F6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 23 kDa subunit family.|||Binds 2 [4Fe-4S] clusters per subunit.|||Cell membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/1705394:SP60_RS00550 ^@ http://purl.uniprot.org/uniprot/A0A0M4PLZ9 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/1705394:SP60_RS05275 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKW3 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/1705394:SP60_RS02595 ^@ http://purl.uniprot.org/uniprot/A0A0M4NGN5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/1705394:SP60_RS02045 ^@ http://purl.uniprot.org/uniprot/A0A0M4NI58 ^@ Similarity ^@ Belongs to the asparagine synthetase family. http://togogenome.org/gene/1705394:SP60_RS07010 ^@ http://purl.uniprot.org/uniprot/A0A0M4PLD3 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS01635 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTT3 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/1705394:SP60_RS08135 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUL9 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/1705394:SP60_RS03280 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEN3 ^@ Function|||Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate. http://togogenome.org/gene/1705394:SP60_RS04470 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWK5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family.|||Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS00510 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTP9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/1705394:SP60_RS04080 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKJ3 ^@ Cofactor ^@ Binds 1 heme c group covalently per subunit. http://togogenome.org/gene/1705394:SP60_RS00500 ^@ http://purl.uniprot.org/uniprot/A0A0M4NSP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS07655 ^@ http://purl.uniprot.org/uniprot/A0A0M4PLK5 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/1705394:SP60_RS03440 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS04925 ^@ http://purl.uniprot.org/uniprot/A0A0M4NTV0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/1705394:SP60_RS02560 ^@ http://purl.uniprot.org/uniprot/A0A0M4NIB4 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/1705394:SP60_RS06745 ^@ http://purl.uniprot.org/uniprot/A0A0M4PNW9 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the RuBisCO small chain family.|||Heterohexadecamer of 8 large and 8 small subunits.|||RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site. Although the small subunit is not catalytic it is essential for maximal activity.|||The basic functional RuBisCO is composed of a large chain homodimer in a 'head-to-tail' conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric 'cap' on each end of the 'barrel'. http://togogenome.org/gene/1705394:SP60_RS00610 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHQ9 ^@ Function|||Similarity ^@ Belongs to the OMP decarboxylase family.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). http://togogenome.org/gene/1705394:SP60_RS00995 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTX6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS04265 ^@ http://purl.uniprot.org/uniprot/A0A0M4NH39 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS04525 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.|||Cell inner membrane http://togogenome.org/gene/1705394:SP60_RS04660 ^@ http://purl.uniprot.org/uniprot/A0A0M4NIY2 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1705394:SP60_RS06055 ^@ http://purl.uniprot.org/uniprot/A0A0M5LL68 ^@ Function|||Similarity|||Subunit ^@ Belongs to the anthranilate synthase component I family.|||Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).|||Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. http://togogenome.org/gene/1705394:SP60_RS00565 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTQ1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS03905 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU09 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/1705394:SP60_RS07240 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJU4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/1705394:SP60_RS00300 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTP1 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/1705394:SP60_RS07060 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHX9 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. http://togogenome.org/gene/1705394:SP60_RS06580 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUA2 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvB family.|||Cytoplasm|||Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.|||Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA. http://togogenome.org/gene/1705394:SP60_RS08325 ^@ http://purl.uniprot.org/uniprot/A0A0M4PMY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS02965 ^@ http://purl.uniprot.org/uniprot/A0A0M4PK75 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiC family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway. http://togogenome.org/gene/1705394:SP60_RS06565 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJM1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/1705394:SP60_RS06595 ^@ http://purl.uniprot.org/uniprot/A0A0M4NUC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ExbD/TolR family.|||Cell inner membrane|||Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.|||The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer. http://togogenome.org/gene/1705394:SP60_RS03220 ^@ http://purl.uniprot.org/uniprot/A0A0M4NTE2 ^@ Similarity ^@ Belongs to the UPF0125 (RnfH) family. http://togogenome.org/gene/1705394:SP60_RS01305 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS05100 ^@ http://purl.uniprot.org/uniprot/A0A0M4P991 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrB/RnfD family.|||Cell inner membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/1705394:SP60_RS06965 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS04385 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEQ9 ^@ Similarity ^@ Belongs to the UPF0102 family. http://togogenome.org/gene/1705394:SP60_RS03740 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/1705394:SP60_RS08145 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Catalyzes the ferrous insertion into protoporphyrin IX.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS00785 ^@ http://purl.uniprot.org/uniprot/A0A0M4NW57 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/1705394:SP60_RS07185 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUC0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1705394:SP60_RS01850 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dsrC/tusE family.|||Cytoplasm|||Part of a sulfur-relay system. http://togogenome.org/gene/1705394:SP60_RS00040 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHI4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BamD family.|||Cell outer membrane|||Part of the Bam complex.|||Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. http://togogenome.org/gene/1705394:SP60_RS03045 ^@ http://purl.uniprot.org/uniprot/A0A0M4NIG4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/1705394:SP60_RS05960 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHL3 ^@ Function|||Similarity ^@ Belongs to the PEP-utilizing enzyme family.|||Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. http://togogenome.org/gene/1705394:SP60_RS04495 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU92 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the class II fructose-bisphosphate aldolase family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.|||Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.|||One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/1705394:SP60_RS07885 ^@ http://purl.uniprot.org/uniprot/A0A0M4PLN1 ^@ Function|||Similarity ^@ Belongs to the Fe(2+)-trafficking protein family.|||Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. http://togogenome.org/gene/1705394:SP60_RS07670 ^@ http://purl.uniprot.org/uniprot/A0A0M4NY35 ^@ Function|||Similarity ^@ A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.|||Belongs to the NifU family. http://togogenome.org/gene/1705394:SP60_RS03570 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKD7 ^@ Similarity ^@ Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. http://togogenome.org/gene/1705394:SP60_RS07305 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS03040 ^@ http://purl.uniprot.org/uniprot/A0A0M4PK82 ^@ Cofactor ^@ Binds 2 Mg(2+) ions per monomer. http://togogenome.org/gene/1705394:SP60_RS03125 ^@ http://purl.uniprot.org/uniprot/A0A0M4NIH2 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/1705394:SP60_RS01510 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.|||Cytoplasm|||Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. http://togogenome.org/gene/1705394:SP60_RS02240 ^@ http://purl.uniprot.org/uniprot/A0A0M4NGI6 ^@ Similarity ^@ Belongs to the polysaccharide synthase family. http://togogenome.org/gene/1705394:SP60_RS05335 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKX1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/1705394:SP60_RS04315 ^@ http://purl.uniprot.org/uniprot/A0A0M4NYC7 ^@ Function ^@ DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes. http://togogenome.org/gene/1705394:SP60_RS05065 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXA9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.|||Belongs to the AAA ATPase family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Homohexamer.|||In the C-terminal section; belongs to the peptidase M41 family.|||In the central section; belongs to the AAA ATPase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS04485 ^@ http://purl.uniprot.org/uniprot/A0A0M4NH56 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1705394:SP60_RS04355 ^@ http://purl.uniprot.org/uniprot/A0A0M5LHJ5 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/1705394:SP60_RS03890 ^@ http://purl.uniprot.org/uniprot/A0A0M4PMV9 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2). http://togogenome.org/gene/1705394:SP60_RS00160 ^@ http://purl.uniprot.org/uniprot/A0A0M4NSK8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS06375 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUF9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1705394:SP60_RS04260 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FtsK/SpoIIIE/SftA family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS06440 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS05820 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS04500 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEJ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/1705394:SP60_RS07435 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUJ5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. http://togogenome.org/gene/1705394:SP60_RS08150 ^@ http://purl.uniprot.org/uniprot/A0A0M4NUU1 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/1705394:SP60_RS02540 ^@ http://purl.uniprot.org/uniprot/A0A0M4P8E8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.|||Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS01465 ^@ http://purl.uniprot.org/uniprot/A0A0M4P821 ^@ Cofactor|||Function ^@ Binds 2 [4Fe-4S] clusters.|||Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. http://togogenome.org/gene/1705394:SP60_RS04725 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKR3 ^@ Function|||Similarity ^@ Belongs to the LpxB family.|||Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. http://togogenome.org/gene/1705394:SP60_RS00180 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTN7 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/1705394:SP60_RS07090 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmC/CycZ/HelC family.|||Cell inner membrane|||Membrane|||Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. http://togogenome.org/gene/1705394:SP60_RS00175 ^@ http://purl.uniprot.org/uniprot/A0A0M5LKJ4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. Biotin synthase family.|||Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS01235 ^@ http://purl.uniprot.org/uniprot/A0A0M4NW96 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS06535 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHS7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit.|||Binds 2 divalent ions per subunit.|||Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.|||Cytoplasm|||Homotetramer; dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS00520 ^@ http://purl.uniprot.org/uniprot/A0A0M5LKK4 ^@ Function|||Similarity ^@ Belongs to the LpxC family.|||Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. http://togogenome.org/gene/1705394:SP60_RS03250 ^@ http://purl.uniprot.org/uniprot/A0A0M5LHG5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial diacylglycerol kinase family.|||Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.|||Cell inner membrane|||Membrane|||Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents. http://togogenome.org/gene/1705394:SP60_RS07665 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.|||Cytoplasm|||Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.|||Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. http://togogenome.org/gene/1705394:SP60_RS04800 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.|||Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS03055 ^@ http://purl.uniprot.org/uniprot/A0A0M5LJ47 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/1705394:SP60_RS07300 ^@ http://purl.uniprot.org/uniprot/A0A0M4PLG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dsrC/tusE family.|||Cytoplasm|||Part of a sulfur-relay system. http://togogenome.org/gene/1705394:SP60_RS03590 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWW3 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/1705394:SP60_RS06040 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUE7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/1705394:SP60_RS00475 ^@ http://purl.uniprot.org/uniprot/A0A0M4NW26 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/1705394:SP60_RS03030 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.|||Cytoplasm|||DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. http://togogenome.org/gene/1705394:SP60_RS04670 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU99 ^@ Cofactor|||Similarity ^@ Belongs to the rubredoxin family.|||Binds 1 Fe(3+) ion per subunit. http://togogenome.org/gene/1705394:SP60_RS04255 ^@ http://purl.uniprot.org/uniprot/A0A0M4NTN8 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/1705394:SP60_RS05885 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU80 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRA-CH family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS00400 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHM7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/1705394:SP60_RS01865 ^@ http://purl.uniprot.org/uniprot/A0A0M4PMC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DsrE/TusD family.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS07425 ^@ http://purl.uniprot.org/uniprot/A0A0M4P9Z9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule. http://togogenome.org/gene/1705394:SP60_RS02630 ^@ http://purl.uniprot.org/uniprot/A0A0M4NIC4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.|||Homotetramer. http://togogenome.org/gene/1705394:SP60_RS06915 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHW7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NapF family.|||Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, before its export into the periplasm.|||Cytoplasm|||Interacts with the cytoplasmic NapA precursor. http://togogenome.org/gene/1705394:SP60_RS07065 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUB6 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/1705394:SP60_RS02590 ^@ http://purl.uniprot.org/uniprot/A0A0M4NT87 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/1705394:SP60_RS01495 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEC8 ^@ Similarity ^@ Belongs to the cyclophilin-type PPIase family. http://togogenome.org/gene/1705394:SP60_RS04035 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEQ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA. http://togogenome.org/gene/1705394:SP60_RS05360 ^@ http://purl.uniprot.org/uniprot/A0A0M4PNE6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/1705394:SP60_RS01140 ^@ http://purl.uniprot.org/uniprot/A0A0M4P7Y9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/1705394:SP60_RS00695 ^@ http://purl.uniprot.org/uniprot/A0A0M4PJK8 ^@ Similarity ^@ Belongs to the RelE toxin family. http://togogenome.org/gene/1705394:SP60_RS00665 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTW6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS05090 ^@ http://purl.uniprot.org/uniprot/A0A0M4NTW3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.|||Binds 3 [4Fe-4S] clusters.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/1705394:SP60_RS04645 ^@ http://purl.uniprot.org/uniprot/A0A0M5LKX0 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/1705394:SP60_RS04115 ^@ http://purl.uniprot.org/uniprot/A0A0M4NTM2 ^@ Function|||Similarity ^@ Belongs to the ribF family.|||Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD. http://togogenome.org/gene/1705394:SP60_RS06755 ^@ http://purl.uniprot.org/uniprot/A0A0M4NUD6 ^@ Similarity ^@ Belongs to the CbbQ/NirQ/NorQ/GpvN family. http://togogenome.org/gene/1705394:SP60_RS00670 ^@ http://purl.uniprot.org/uniprot/A0A0M4PLS6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/1705394:SP60_RS06385 ^@ http://purl.uniprot.org/uniprot/A0A0M4NUA4 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/1705394:SP60_RS07350 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUC6 ^@ Similarity ^@ Belongs to the YjdM family. http://togogenome.org/gene/1705394:SP60_RS04730 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUA1 ^@ Function|||Similarity ^@ Belongs to the NadC/ModD family.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/1705394:SP60_RS04515 ^@ http://purl.uniprot.org/uniprot/A0A0M4NX54 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/1705394:SP60_RS04375 ^@ http://purl.uniprot.org/uniprot/A0A0M4NX37 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/1705394:SP60_RS03875 ^@ http://purl.uniprot.org/uniprot/A0A0M4NIQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS03785 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU05 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/1705394:SP60_RS05690 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS06340 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEN4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS04030 ^@ http://purl.uniprot.org/uniprot/A0A0M4NX04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/1705394:SP60_RS06270 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXN7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.|||Membrane|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule. http://togogenome.org/gene/1705394:SP60_RS05105 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUB5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RnfG family.|||Cell inner membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/1705394:SP60_RS03475 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YajC family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS00545 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEK3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS03970 ^@ http://purl.uniprot.org/uniprot/A0A0M4PMW5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase U32 family. UbiV subfamily.|||Forms an heterodimer with UbiU.|||Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiU, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway. http://togogenome.org/gene/1705394:SP60_RS03585 ^@ http://purl.uniprot.org/uniprot/A0A0M4NIL6 ^@ Similarity ^@ Belongs to the UPF0246 family. http://togogenome.org/gene/1705394:SP60_RS05940 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter large permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/1705394:SP60_RS07150 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUI5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/1705394:SP60_RS01620 ^@ http://purl.uniprot.org/uniprot/A0A0M5LKV4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapB family.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.|||Cytoplasm|||Homotetramer.|||Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. http://togogenome.org/gene/1705394:SP60_RS05490 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUC9 ^@ Function|||Similarity ^@ Belongs to the nucleoside phosphorylase PpnP family.|||Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. http://togogenome.org/gene/1705394:SP60_RS07575 ^@ http://purl.uniprot.org/uniprot/A0A0M4NI37 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/1705394:SP60_RS01920 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTU3 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/1705394:SP60_RS01960 ^@ http://purl.uniprot.org/uniprot/A0A0M4P881 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dsrC/tusE family.|||Cytoplasm|||Part of a sulfur-relay system. http://togogenome.org/gene/1705394:SP60_RS05085 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell inner membrane|||Membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/1705394:SP60_RS01695 ^@ http://purl.uniprot.org/uniprot/A0A0M4PJV8 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/1705394:SP60_RS08420 ^@ http://purl.uniprot.org/uniprot/A0A0M4P9L1 ^@ Function|||Similarity ^@ Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.|||Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. http://togogenome.org/gene/1705394:SP60_RS06370 ^@ http://purl.uniprot.org/uniprot/A0A0M4PNS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS07070 ^@ http://purl.uniprot.org/uniprot/A0A0M4P9V7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6. http://togogenome.org/gene/1705394:SP60_RS01750 ^@ http://purl.uniprot.org/uniprot/A0A0M4P855 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcdB/MmdB/OadB family.|||Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.|||Cell membrane|||Heterotrimer of an alpha, a beta and a gamma subunit.|||Membrane http://togogenome.org/gene/1705394:SP60_RS06470 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU98 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS04765 ^@ http://purl.uniprot.org/uniprot/A0A0M4PN84 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS00245 ^@ http://purl.uniprot.org/uniprot/A0A0M5LH86 ^@ Function|||Similarity ^@ Belongs to the DUF177 domain family.|||Plays a role in synthesis, processing and/or stability of 23S rRNA. http://togogenome.org/gene/1705394:SP60_RS06165 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter large permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/1705394:SP60_RS07455 ^@ http://purl.uniprot.org/uniprot/A0A0M4NY11 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/1705394:SP60_RS05355 ^@ http://purl.uniprot.org/uniprot/A0A0M5LET6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/1705394:SP60_RS04635 ^@ http://purl.uniprot.org/uniprot/A0A0M4NH72 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1705394:SP60_RS07295 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUC4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1705394:SP60_RS04140 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKK0 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/1705394:SP60_RS01020 ^@ http://purl.uniprot.org/uniprot/A0A0M4PJP0 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/1705394:SP60_RS06335 ^@ http://purl.uniprot.org/uniprot/A0A0M4P9M9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HemJ family.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|||Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/1705394:SP60_RS06135 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transpeptidase family. MrdA subfamily.|||Catalyzes cross-linking of the peptidoglycan cell wall.|||Cell inner membrane http://togogenome.org/gene/1705394:SP60_RS04710 ^@ http://purl.uniprot.org/uniprot/A0A0M4P953 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the L/F-transferase family.|||Cytoplasm|||Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. http://togogenome.org/gene/1705394:SP60_RS06360 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXP5 ^@ Function|||Similarity ^@ Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.|||Belongs to the Nudix hydrolase family. RppH subfamily. http://togogenome.org/gene/1705394:SP60_RS07535 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEX7 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/1705394:SP60_RS01400 ^@ http://purl.uniprot.org/uniprot/A0A0M4PJS6 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/1705394:SP60_RS06145 ^@ http://purl.uniprot.org/uniprot/A0A0M5LF19 ^@ Similarity ^@ Belongs to the MreC family. http://togogenome.org/gene/1705394:SP60_RS05325 ^@ http://purl.uniprot.org/uniprot/A0A0M4P9B6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/1705394:SP60_RS03480 ^@ http://purl.uniprot.org/uniprot/A0A0M4NIK7 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS00750 ^@ http://purl.uniprot.org/uniprot/A0A0M4NSS3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the serine/threonine dehydratase family.|||Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.|||Homotetramer. http://togogenome.org/gene/1705394:SP60_RS01350 ^@ http://purl.uniprot.org/uniprot/A0A0M4NVM3 ^@ Similarity ^@ Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. http://togogenome.org/gene/1705394:SP60_RS00480 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS06710 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS01420 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUM5 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/1705394:SP60_RS04090 ^@ http://purl.uniprot.org/uniprot/A0A0M4NX11 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.|||Membrane|||The Rieske protein is a high potential 2Fe-2S protein.|||The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein. http://togogenome.org/gene/1705394:SP60_RS03085 ^@ http://purl.uniprot.org/uniprot/A0A0M5LET3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the thioredoxin family. DsbA subfamily.|||Periplasm http://togogenome.org/gene/1705394:SP60_RS06280 ^@ http://purl.uniprot.org/uniprot/A0A0M5LES5 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/1705394:SP60_RS01630 ^@ http://purl.uniprot.org/uniprot/A0A0M4NI12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KdsA family.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS01145 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEA0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 1 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/1705394:SP60_RS00440 ^@ http://purl.uniprot.org/uniprot/A0A0M4NSN7 ^@ Function ^@ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/1705394:SP60_RS03465 ^@ http://purl.uniprot.org/uniprot/A0A0M5LL04 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecF subfamily.|||Cell membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/1705394:SP60_RS07075 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEQ4 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with bS18 to 16S ribosomal RNA. http://togogenome.org/gene/1705394:SP60_RS00165 ^@ http://purl.uniprot.org/uniprot/A0A0M4NFT9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family. MurG subfamily.|||Cell membrane|||Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS03240 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTY7 ^@ Function|||Similarity ^@ Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.|||Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system. http://togogenome.org/gene/1705394:SP60_RS05390 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUC5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/1705394:SP60_RS00515 ^@ http://purl.uniprot.org/uniprot/A0A0M4P7R4 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/1705394:SP60_RS01525 ^@ http://purl.uniprot.org/uniprot/A0A0M4NG93 ^@ Function|||Similarity ^@ Belongs to the class-I DAHP synthase family.|||Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). http://togogenome.org/gene/1705394:SP60_RS06620 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEP5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS04900 ^@ http://purl.uniprot.org/uniprot/A0A0M5LJ91 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/1705394:SP60_RS02675 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU34 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YciB family.|||Cell inner membrane|||Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis. http://togogenome.org/gene/1705394:SP60_RS05070 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEV2 ^@ Function|||Similarity ^@ Belongs to the DHPS family.|||Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives. http://togogenome.org/gene/1705394:SP60_RS06025 ^@ http://purl.uniprot.org/uniprot/A0A0M4PNN0 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/1705394:SP60_RS03885 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEQ7 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/1705394:SP60_RS07630 ^@ http://purl.uniprot.org/uniprot/A0A0M4NUM5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1705394:SP60_RS06695 ^@ http://purl.uniprot.org/uniprot/A0A0M4NKD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1705394:SP60_RS00795 ^@ http://purl.uniprot.org/uniprot/A0A0M5LIZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate 5-kinase family.|||Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS02610 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEF2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LptF/LptG family.|||Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).|||Membrane|||Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. http://togogenome.org/gene/1705394:SP60_RS04590 ^@ http://purl.uniprot.org/uniprot/A0A0M4NIX4 ^@ Similarity ^@ Belongs to the sulfate adenylyltransferase family. http://togogenome.org/gene/1705394:SP60_RS01540 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEA8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.|||Cell membrane|||Heterotetramer composed of ParC and ParE.|||Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. http://togogenome.org/gene/1705394:SP60_RS03120 ^@ http://purl.uniprot.org/uniprot/A0A0M4NK87 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/1705394:SP60_RS04520 ^@ http://purl.uniprot.org/uniprot/A0A0M5LJ83 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/1705394:SP60_RS05535 ^@ http://purl.uniprot.org/uniprot/A0A0M4P9E1 ^@ Function|||Similarity ^@ Belongs to the thymidylate kinase family.|||Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. http://togogenome.org/gene/1705394:SP60_RS05255 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHD4 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||Methylated by PrmB.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/1705394:SP60_RS03330 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS00115 ^@ http://purl.uniprot.org/uniprot/A0A0M5LKQ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS00005 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTN2 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.|||In the C-terminal section; belongs to the NAD synthetase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS07190 ^@ http://purl.uniprot.org/uniprot/A0A0M4PP22 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1705394:SP60_RS08025 ^@ http://purl.uniprot.org/uniprot/A0A0M5LHS7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.|||Cytoplasm|||Heteromultimer composed of HisG and HisZ subunits.|||Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.|||This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one. http://togogenome.org/gene/1705394:SP60_RS04190 ^@ http://purl.uniprot.org/uniprot/A0A0M4NH35 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Binds 1 copper ion per subunit, denoted as copper B.|||Binds 2 heme groups per subunit, denoted as high- and low-spin.|||Membrane http://togogenome.org/gene/1705394:SP60_RS05865 ^@ http://purl.uniprot.org/uniprot/A0A0M4NX05 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.|||The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. http://togogenome.org/gene/1705394:SP60_RS02670 ^@ http://purl.uniprot.org/uniprot/A0A0M4P8G6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvT family.|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/1705394:SP60_RS07500 ^@ http://purl.uniprot.org/uniprot/A0A0M4PA06 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS1 family.|||Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. http://togogenome.org/gene/1705394:SP60_RS05305 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWU4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/1705394:SP60_RS04790 ^@ http://purl.uniprot.org/uniprot/A0A0M4P960 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS01355 ^@ http://purl.uniprot.org/uniprot/A0A0M4NSX8 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/1705394:SP60_RS01760 ^@ http://purl.uniprot.org/uniprot/A0A0M4PJW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OadG family.|||Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.|||Cell membrane http://togogenome.org/gene/1705394:SP60_RS07785 ^@ http://purl.uniprot.org/uniprot/A0A0M4NUP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsuA/YedE (TC 9.B.102) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS02405 ^@ http://purl.uniprot.org/uniprot/A0A0M5LKR3 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/1705394:SP60_RS07830 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUE2 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/1705394:SP60_RS03655 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWX1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/1705394:SP60_RS05860 ^@ http://purl.uniprot.org/uniprot/A0A0M4PNL0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS00125 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS00305 ^@ http://purl.uniprot.org/uniprot/A0A0M4NSM1 ^@ Activity Regulation|||Caution|||Domain|||Function|||Similarity ^@ Belongs to the GlnD family.|||Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.|||Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity. http://togogenome.org/gene/1705394:SP60_RS00255 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsX family.|||Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.|||Cytoplasm|||Homodimer. Probably interacts with PlsY. http://togogenome.org/gene/1705394:SP60_RS05345 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJ77 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1705394:SP60_RS02535 ^@ http://purl.uniprot.org/uniprot/A0A0M4NGM9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family.|||Binds 1 Mg(2+) ion per monomer.|||Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. http://togogenome.org/gene/1705394:SP60_RS00410 ^@ http://purl.uniprot.org/uniprot/A0A0M4NW17 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/1705394:SP60_RS04345 ^@ http://purl.uniprot.org/uniprot/A0A0M4NH43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/1705394:SP60_RS07700 ^@ http://purl.uniprot.org/uniprot/A0A0M4NUN4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer.|||In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.|||In the N-terminal section; belongs to the MIP18 family. http://togogenome.org/gene/1705394:SP60_RS06460 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHR8 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/1705394:SP60_RS00450 ^@ http://purl.uniprot.org/uniprot/A0A0M4P7Q6 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/1705394:SP60_RS00575 ^@ http://purl.uniprot.org/uniprot/A0A0M4NSQ3 ^@ Similarity ^@ Belongs to the UbiH/COQ6 family. http://togogenome.org/gene/1705394:SP60_RS06450 ^@ http://purl.uniprot.org/uniprot/A0A0M4NX72 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseA family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/1705394:SP60_RS06075 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXL5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SoxA family.|||Binds 2 heme groups per subunit.|||Heterodimer of SoxA and SoxX.|||Periplasm http://togogenome.org/gene/1705394:SP60_RS02970 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU40 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.|||Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS05230 ^@ http://purl.uniprot.org/uniprot/A0A0M4NUY8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/1705394:SP60_RS01990 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU10 ^@ Similarity ^@ Belongs to the UDPGP type 2 family. http://togogenome.org/gene/1705394:SP60_RS05635 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXH0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 20 kDa subunit family.|||Binds 1 [4Fe-4S] cluster.|||Cell membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/1705394:SP60_RS01245 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXS9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.|||Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS05350 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXE2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1705394:SP60_RS06350 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJJ1 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/1705394:SP60_RS03435 ^@ http://purl.uniprot.org/uniprot/A0A0M4PMS8 ^@ Function ^@ Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. http://togogenome.org/gene/1705394:SP60_RS03810 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU67 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS04880 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKS8 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/1705394:SP60_RS05320 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU61 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/1705394:SP60_RS04055 ^@ http://purl.uniprot.org/uniprot/A0A0M4NTL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS04135 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEJ0 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1705394:SP60_RS07165 ^@ http://purl.uniprot.org/uniprot/A0A0M4PLF0 ^@ Similarity ^@ Belongs to the RecJ family. http://togogenome.org/gene/1705394:SP60_RS01335 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEM5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the FPG family.|||Binds 1 zinc ion per subunit.|||Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.|||Monomer. http://togogenome.org/gene/1705394:SP60_RS00095 ^@ http://purl.uniprot.org/uniprot/A0A0M4NFT0 ^@ Domain|||Function|||Similarity ^@ Belongs to the vitamin-B12 dependent methionine synthase family.|||Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.|||Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin. http://togogenome.org/gene/1705394:SP60_RS03770 ^@ http://purl.uniprot.org/uniprot/A0A0M4NH04 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/1705394:SP60_RS00980 ^@ http://purl.uniprot.org/uniprot/A0A0M4PM32 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS00370 ^@ http://purl.uniprot.org/uniprot/A0A0M4NSM9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YbaB/EbfC family.|||Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.|||Homodimer.|||nucleoid http://togogenome.org/gene/1705394:SP60_RS07280 ^@ http://purl.uniprot.org/uniprot/A0A0M4NI01 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS02605 ^@ http://purl.uniprot.org/uniprot/A0A0M4P8F7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ClpS family.|||Binds to the N-terminal domain of the chaperone ClpA.|||Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation. http://togogenome.org/gene/1705394:SP60_RS01965 ^@ http://purl.uniprot.org/uniprot/A0A0M5LKW4 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS01500 ^@ http://purl.uniprot.org/uniprot/A0A0M4PM84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS03135 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.|||Catalyzes the oxidation of L-aspartate to iminoaspartate.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS00955 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHU3 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1705394:SP60_RS03290 ^@ http://purl.uniprot.org/uniprot/A0A0M4NW70 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/1705394:SP60_RS03790 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. http://togogenome.org/gene/1705394:SP60_RS04165 ^@ http://purl.uniprot.org/uniprot/A0A0M5LJ74 ^@ Caution|||Function|||Similarity ^@ Belongs to the DXR family.|||Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS08010 ^@ http://purl.uniprot.org/uniprot/A0A0M4NI85 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LptD family.|||Cell outer membrane|||Component of the lipopolysaccharide transport and assembly complex. Interacts with LptE and LptA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. http://togogenome.org/gene/1705394:SP60_RS00140 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEC3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DHBP synthase family.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Homodimer.|||In the C-terminal section; belongs to the GTP cyclohydrolase II family.|||In the N-terminal section; belongs to the DHBP synthase family. http://togogenome.org/gene/1705394:SP60_RS06785 ^@ http://purl.uniprot.org/uniprot/A0A0M4PLA7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS06190 ^@ http://purl.uniprot.org/uniprot/A0A0M4PL78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell inner membrane|||Membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/1705394:SP60_RS03775 ^@ http://purl.uniprot.org/uniprot/A0A0M4P8T9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/1705394:SP60_RS07680 ^@ http://purl.uniprot.org/uniprot/A0A0M4PP77 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HscB family.|||Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA.|||Interacts with HscA and stimulates its ATPase activity. http://togogenome.org/gene/1705394:SP60_RS01935 ^@ http://purl.uniprot.org/uniprot/A0A0M4PMD1 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/1705394:SP60_RS04465 ^@ http://purl.uniprot.org/uniprot/A0A0M4PN21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.|||Cell inner membrane|||Cell membrane|||Membrane|||Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. http://togogenome.org/gene/1705394:SP60_RS05795 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS01745 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTT7 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanD family.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.|||Cytoplasm|||Heterooctamer of four alpha and four beta subunits.|||Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus. http://togogenome.org/gene/1705394:SP60_RS07385 ^@ http://purl.uniprot.org/uniprot/A0A0M4NY06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP synthase family.|||Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.|||Cytoplasm|||Homooctamer; tetramer of dimers. http://togogenome.org/gene/1705394:SP60_RS03830 ^@ http://purl.uniprot.org/uniprot/A0A0M4NTJ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/1705394:SP60_RS02600 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTW7 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/1705394:SP60_RS03600 ^@ http://purl.uniprot.org/uniprot/A0A0M4PMU1 ^@ Function|||Similarity ^@ Belongs to the dihydrofolate reductase family.|||Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. http://togogenome.org/gene/1705394:SP60_RS04400 ^@ http://purl.uniprot.org/uniprot/A0A0M5LJI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CoaE family.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS05340 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUC3 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1705394:SP60_RS03265 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU50 ^@ Function|||Similarity ^@ Belongs to the beta-class carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/1705394:SP60_RS01085 ^@ http://purl.uniprot.org/uniprot/A0A0M4PJP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/1705394:SP60_RS04625 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWM3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.|||Cell membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. http://togogenome.org/gene/1705394:SP60_RS05925 ^@ http://purl.uniprot.org/uniprot/A0A0M5LES0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS03005 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTX9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/1705394:SP60_RS07245 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUC2 ^@ Domain|||Function|||Similarity ^@ Belongs to the RecA family. RadA subfamily.|||DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.|||Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.|||The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. http://togogenome.org/gene/1705394:SP60_RS05805 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHJ8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M20A family. DapE subfamily.|||Binds 2 Zn(2+) or Co(2+) ions per subunit.|||Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS01225 ^@ http://purl.uniprot.org/uniprot/A0A0M4PJR3 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/1705394:SP60_RS04050 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWF1 ^@ Similarity ^@ Belongs to the phosphoribulokinase family. http://togogenome.org/gene/1705394:SP60_RS05755 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS08175 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS05050 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyl phosphate reductase family.|||Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS04745 ^@ http://purl.uniprot.org/uniprot/A0A0M4NIZ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoD/SigA subfamily.|||Cytoplasm|||Interacts transiently with the RNA polymerase catalytic core.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. http://togogenome.org/gene/1705394:SP60_RS05225 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEL4 ^@ Similarity ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family. http://togogenome.org/gene/1705394:SP60_RS00485 ^@ http://purl.uniprot.org/uniprot/A0A0M5LED7 ^@ Function|||Similarity ^@ Belongs to the QueH family.|||Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). http://togogenome.org/gene/1705394:SP60_RS04300 ^@ http://purl.uniprot.org/uniprot/A0A0M4NX30 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YqgF HJR family.|||Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS07880 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/1705394:SP60_RS03560 ^@ http://purl.uniprot.org/uniprot/A0A0M4P8R4 ^@ Subcellular Location Annotation ^@ Cell inner membrane http://togogenome.org/gene/1705394:SP60_RS07605 ^@ http://purl.uniprot.org/uniprot/A0A0M4NY27 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS02005 ^@ http://purl.uniprot.org/uniprot/A0A0M4NVT5 ^@ Similarity ^@ Belongs to the bacterial sugar transferase family. http://togogenome.org/gene/1705394:SP60_RS05815 ^@ http://purl.uniprot.org/uniprot/A0A0M5LHM1 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/1705394:SP60_RS04105 ^@ http://purl.uniprot.org/uniprot/A0A0M4PMX7 ^@ Function|||Similarity ^@ Belongs to the anhydro-N-acetylmuramic acid kinase family.|||Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. http://togogenome.org/gene/1705394:SP60_RS03915 ^@ http://purl.uniprot.org/uniprot/A0A0M4NH17 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/1705394:SP60_RS05455 ^@ http://purl.uniprot.org/uniprot/A0A0M5LHL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/1705394:SP60_RS05445 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHG0 ^@ PTM ^@ Binds 2 heme c groups covalently per subunit. http://togogenome.org/gene/1705394:SP60_RS04335 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RimP family.|||Cytoplasm|||Required for maturation of 30S ribosomal subunits. http://togogenome.org/gene/1705394:SP60_RS01095 ^@ http://purl.uniprot.org/uniprot/A0A0M4NW81 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/1705394:SP60_RS06705 ^@ http://purl.uniprot.org/uniprot/A0A0M4P9S0 ^@ Function|||Similarity ^@ Belongs to the PurU family.|||Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). http://togogenome.org/gene/1705394:SP60_RS00910 ^@ http://purl.uniprot.org/uniprot/A0A0M4P7W4 ^@ Function|||Subunit ^@ DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease. http://togogenome.org/gene/1705394:SP60_RS07310 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXZ8 ^@ Function|||Similarity ^@ Belongs to the ParB family.|||Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication. http://togogenome.org/gene/1705394:SP60_RS01460 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTS7 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.|||Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA. http://togogenome.org/gene/1705394:SP60_RS05460 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKY7 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/1705394:SP60_RS00260 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHL0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/1705394:SP60_RS00855 ^@ http://purl.uniprot.org/uniprot/A0A0M4PJM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS06365 ^@ http://purl.uniprot.org/uniprot/A0A0M5LJD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS04215 ^@ http://purl.uniprot.org/uniprot/A0A0M5LL21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS04110 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWG3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS03415 ^@ http://purl.uniprot.org/uniprot/A0A0M4NIK0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS05895 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEN1 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/1705394:SP60_RS01485 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHZ4 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1705394:SP60_RS04230 ^@ http://purl.uniprot.org/uniprot/A0A0M4NX26 ^@ Similarity ^@ Belongs to the CbbQ/NirQ/NorQ/GpvN family. http://togogenome.org/gene/1705394:SP60_RS01955 ^@ http://purl.uniprot.org/uniprot/A0A0M4NGE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. PrmA family.|||Cytoplasm|||Methylates ribosomal protein L11. http://togogenome.org/gene/1705394:SP60_RS04160 ^@ http://purl.uniprot.org/uniprot/A0A0M4NX19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS04695 ^@ http://purl.uniprot.org/uniprot/A0A0M4NTS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0126 family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS03410 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKC1 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/1705394:SP60_RS05710 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU74 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily.|||Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. http://togogenome.org/gene/1705394:SP60_RS00270 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseB family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/1705394:SP60_RS04060 ^@ http://purl.uniprot.org/uniprot/A0A0M4NH29 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS07030 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUI1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS06865 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Cytoplasm|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. http://togogenome.org/gene/1705394:SP60_RS05595 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS00505 ^@ http://purl.uniprot.org/uniprot/A0A0M4NFX8 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS06575 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEU9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LolB family.|||Cell outer membrane|||Membrane|||Monomer. http://togogenome.org/gene/1705394:SP60_RS04890 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU45 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/1705394:SP60_RS06805 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEW1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS07340 ^@ http://purl.uniprot.org/uniprot/A0A0M4NUJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell membrane http://togogenome.org/gene/1705394:SP60_RS04085 ^@ http://purl.uniprot.org/uniprot/A0A0M4NIR8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.|||Membrane|||The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein. http://togogenome.org/gene/1705394:SP60_RS05600 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU70 ^@ Cofactor|||Similarity ^@ Belongs to the PyrK family.|||Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/1705394:SP60_RS05265 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEL2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/1705394:SP60_RS03470 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTZ5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell membrane|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/1705394:SP60_RS01910 ^@ http://purl.uniprot.org/uniprot/A0A0M4NI43 ^@ Cofactor ^@ Can also use Mn(2+) ion. http://togogenome.org/gene/1705394:SP60_RS04565 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXV4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1705394:SP60_RS06590 ^@ http://purl.uniprot.org/uniprot/A0A0M4NX88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS03870 ^@ http://purl.uniprot.org/uniprot/A0A0M5LET5 ^@ Function|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.|||This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/1705394:SP60_RS00800 ^@ http://purl.uniprot.org/uniprot/A0A0M4PM22 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1705394:SP60_RS02160 ^@ http://purl.uniprot.org/uniprot/A0A0M4P8A6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS05135 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU54 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/1705394:SP60_RS03610 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.|||Cytoplasm|||In the C-terminal section; belongs to the helicase family. RecG subfamily.|||In the N-terminal section; belongs to the UvrB family. http://togogenome.org/gene/1705394:SP60_RS01220 ^@ http://purl.uniprot.org/uniprot/A0A0M5LKU4 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/1705394:SP60_RS00200 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerC subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/1705394:SP60_RS03850 ^@ http://purl.uniprot.org/uniprot/A0A0M4P8U7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1705394:SP60_RS07095 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmE/CycJ family.|||Cell membrane|||Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. http://togogenome.org/gene/1705394:SP60_RS05385 ^@ http://purl.uniprot.org/uniprot/A0A0M4P9C5 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/1705394:SP60_RS00250 ^@ http://purl.uniprot.org/uniprot/A0A0M4PJF5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/1705394:SP60_RS03805 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Cell membrane|||Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.|||Membrane http://togogenome.org/gene/1705394:SP60_RS07940 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/1705394:SP60_RS05630 ^@ http://purl.uniprot.org/uniprot/A0A0M5LL76 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 3 family.|||Cell membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/1705394:SP60_RS03420 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTZ3 ^@ Cofactor|||Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/1705394:SP60_RS06035 ^@ http://purl.uniprot.org/uniprot/A0A0M4NU67 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/1705394:SP60_RS07585 ^@ http://purl.uniprot.org/uniprot/A0A0M5LL46 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1705394:SP60_RS05280 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJ70 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/1705394:SP60_RS07615 ^@ http://purl.uniprot.org/uniprot/A0A0M5LF51 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/1705394:SP60_RS01290 ^@ http://purl.uniprot.org/uniprot/A0A0M4P807 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/1705394:SP60_RS03860 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKH0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type-II 3-dehydroquinase family.|||Catalyzes a trans-dehydration via an enolate intermediate.|||Homododecamer. http://togogenome.org/gene/1705394:SP60_RS06520 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUA0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1705394:SP60_RS05450 ^@ http://purl.uniprot.org/uniprot/A0A0M4P9D5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/1705394:SP60_RS03975 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWE2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase U32 family. UbiU subfamily.|||Forms an heterodimer with UbiV.|||Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiV, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway. http://togogenome.org/gene/1705394:SP60_RS07440 ^@ http://purl.uniprot.org/uniprot/A0A0M5LER3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATP phosphoribosyltransferase family. Short subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Heteromultimer composed of HisG and HisZ subunits.|||Lacks the C-terminal regulatory region which is replaced by HisZ. http://togogenome.org/gene/1705394:SP60_RS05640 ^@ http://purl.uniprot.org/uniprot/A0A0M5LJB1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 30 kDa subunit family.|||Cell membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/1705394:SP60_RS05270 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU59 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/1705394:SP60_RS01175 ^@ http://purl.uniprot.org/uniprot/A0A0M5LJ04 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the helicase family. DinG subfamily. Type 1 sub-subfamily.|||Binds 1 [4Fe-4S] cluster.|||DNA-dependent ATPase and 5'-3' DNA helicase. http://togogenome.org/gene/1705394:SP60_RS05550 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKZ8 ^@ Similarity ^@ Belongs to the LOG family. http://togogenome.org/gene/1705394:SP60_RS05165 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUB7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/1705394:SP60_RS04490 ^@ http://purl.uniprot.org/uniprot/A0A0M4P923 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/1705394:SP60_RS06210 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXM9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.|||Cytoplasm|||Homodimer.|||Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. http://togogenome.org/gene/1705394:SP60_RS03105 ^@ http://purl.uniprot.org/uniprot/A0A0M4PK90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS08040 ^@ http://purl.uniprot.org/uniprot/A0A0M4PAG7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS06505 ^@ http://purl.uniprot.org/uniprot/A0A0M5LF28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS03295 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTY9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/1705394:SP60_RS01265 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUF8 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/1705394:SP60_RS04350 ^@ http://purl.uniprot.org/uniprot/A0A0M4P905 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/1705394:SP60_RS03065 ^@ http://purl.uniprot.org/uniprot/A0A0M4PMP5 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS07970 ^@ http://purl.uniprot.org/uniprot/A0A0M4NK29 ^@ Similarity ^@ Belongs to the UPF0250 family. http://togogenome.org/gene/1705394:SP60_RS05740 ^@ http://purl.uniprot.org/uniprot/A0A0M4P9G4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/1705394:SP60_RS07195 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXF7 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/1705394:SP60_RS03445 ^@ http://purl.uniprot.org/uniprot/A0A0M4NW86 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS06475 ^@ http://purl.uniprot.org/uniprot/A0A0M4P9P5 ^@ Similarity ^@ Belongs to the PhoH family. http://togogenome.org/gene/1705394:SP60_RS01775 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU02 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/1705394:SP60_RS06235 ^@ http://purl.uniprot.org/uniprot/A0A0M4NU90 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Monomer.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/1705394:SP60_RS07835 ^@ http://purl.uniprot.org/uniprot/A0A0M4NY51 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/1705394:SP60_RS05685 ^@ http://purl.uniprot.org/uniprot/A0A0M4PL07 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS05370 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU63 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/1705394:SP60_RS07270 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS01260 ^@ http://purl.uniprot.org/uniprot/A0A0M4PM60 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/1705394:SP60_RS06995 ^@ http://purl.uniprot.org/uniprot/A0A0M4P9V0 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/1705394:SP60_RS00045 ^@ http://purl.uniprot.org/uniprot/A0A0M4NVY0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS06540 ^@ http://purl.uniprot.org/uniprot/A0A0M4P9Q4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmB/CycW/HelB family.|||Cell inner membrane|||Membrane|||Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. http://togogenome.org/gene/1705394:SP60_RS04770 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWP3 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/1705394:SP60_RS05675 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUD5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 6 family.|||Cell membrane|||Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/1705394:SP60_RS06825 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUA9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/1705394:SP60_RS04855 ^@ http://purl.uniprot.org/uniprot/A0A0M4NTU4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccA family.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS07460 ^@ http://purl.uniprot.org/uniprot/A0A0M5LJF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS00895 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTR0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.|||Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.|||Homotetramer; dimer of dimers.|||Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate. http://togogenome.org/gene/1705394:SP60_RS06650 ^@ http://purl.uniprot.org/uniprot/A0A0M4PNW1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS01545 ^@ http://purl.uniprot.org/uniprot/A0A0M4PJU2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family.|||Homotetramer.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/1705394:SP60_RS02955 ^@ http://purl.uniprot.org/uniprot/A0A0M4P8J3 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/1705394:SP60_RS03400 ^@ http://purl.uniprot.org/uniprot/A0A0M4PPF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A24 family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS03730 ^@ http://purl.uniprot.org/uniprot/A0A0M4NIM9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/1705394:SP60_RS01900 ^@ http://purl.uniprot.org/uniprot/A0A0M4PJX5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class II aldolase/RraA-like family.|||Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.|||Homotrimer. http://togogenome.org/gene/1705394:SP60_RS04120 ^@ http://purl.uniprot.org/uniprot/A0A0M4NH32 ^@ Cofactor|||Function|||Similarity ^@ Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).|||Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/1705394:SP60_RS05935 ^@ http://purl.uniprot.org/uniprot/A0A0M4NX13 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MraZ family.|||Forms oligomers.|||nucleoid http://togogenome.org/gene/1705394:SP60_RS06100 ^@ http://purl.uniprot.org/uniprot/A0A0M4NU75 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion.|||Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.|||In the C-terminal section; belongs to the HTP reductase family.|||In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/1705394:SP60_RS03495 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU56 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/1705394:SP60_RS04955 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU47 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily. http://togogenome.org/gene/1705394:SP60_RS03640 ^@ http://purl.uniprot.org/uniprot/A0A0M5LHH7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspH family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. http://togogenome.org/gene/1705394:SP60_RS01010 ^@ http://purl.uniprot.org/uniprot/A0A0M4NK63 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||In the N-terminal section; belongs to the FGAMS family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. http://togogenome.org/gene/1705394:SP60_RS02550 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTW5 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. http://togogenome.org/gene/1705394:SP60_RS00365 ^@ http://purl.uniprot.org/uniprot/A0A0M4NVB9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DnaX/STICHEL family.|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/1705394:SP60_RS02395 ^@ http://purl.uniprot.org/uniprot/A0A0M4P8C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gmhB family.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS06490 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUG3 ^@ Similarity ^@ Belongs to the SCO1/2 family. http://togogenome.org/gene/1705394:SP60_RS08030 ^@ http://purl.uniprot.org/uniprot/A0A0M4PLQ5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/1705394:SP60_RS05290 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUC1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1705394:SP60_RS00310 ^@ http://purl.uniprot.org/uniprot/A0A0M4NFV3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Monomer. http://togogenome.org/gene/1705394:SP60_RS05410 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXE9 ^@ Caution|||Function|||Similarity ^@ Belongs to the UbiX/PAD1 family.|||Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS06635 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUA4 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/1705394:SP60_RS07170 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJT6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS07705 ^@ http://purl.uniprot.org/uniprot/A0A0M4NI51 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. http://togogenome.org/gene/1705394:SP60_RS00905 ^@ http://purl.uniprot.org/uniprot/A0A0M4NG31 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase subunit omega family.|||Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1705394:SP60_RS01410 ^@ http://purl.uniprot.org/uniprot/A0A0M4PAA8 ^@ Similarity ^@ Belongs to the radical SAM superfamily. KamA family. http://togogenome.org/gene/1705394:SP60_RS00660 ^@ http://purl.uniprot.org/uniprot/A0A0M4NSR5 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/1705394:SP60_RS00820 ^@ http://purl.uniprot.org/uniprot/A0A0M4NG22 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS06905 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUH7 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.|||Binds 1 [4Fe-4S] cluster.|||Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.|||Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.|||Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.|||Periplasm|||Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. http://togogenome.org/gene/1705394:SP60_RS03225 ^@ http://purl.uniprot.org/uniprot/A0A0M4NGV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS00885 ^@ http://purl.uniprot.org/uniprot/A0A0M4PM28 ^@ Function|||Similarity ^@ Belongs to the aconitase/IPM isomerase family.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. http://togogenome.org/gene/1705394:SP60_RS05680 ^@ http://purl.uniprot.org/uniprot/A0A0M5LL64 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Cell membrane|||Membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/1705394:SP60_RS05750 ^@ http://purl.uniprot.org/uniprot/A0A0M4PL15 ^@ Function|||Similarity ^@ Belongs to the GART family.|||Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. http://togogenome.org/gene/1705394:SP60_RS06990 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHX2 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/1705394:SP60_RS06150 ^@ http://purl.uniprot.org/uniprot/A0A0M4PNP7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers. http://togogenome.org/gene/1705394:SP60_RS02415 ^@ http://purl.uniprot.org/uniprot/A0A0M4PK39 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SIS family. GmhA subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate. http://togogenome.org/gene/1705394:SP60_RS07690 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUD8 ^@ Similarity ^@ Belongs to the adrenodoxin/putidaredoxin family. http://togogenome.org/gene/1705394:SP60_RS04935 ^@ http://purl.uniprot.org/uniprot/A0A0M4P976 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Belongs to the DNA photolyase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/1705394:SP60_RS03275 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWT0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/1705394:SP60_RS07025 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXW9 ^@ Similarity ^@ Belongs to the YfgM family. http://togogenome.org/gene/1705394:SP60_RS07860 ^@ http://purl.uniprot.org/uniprot/A0A0M4NUQ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type II topoisomerase GyrB family.|||Belongs to the type II topoisomerase family. ParE type 1 subfamily.|||Heterotetramer composed of ParC and ParE.|||Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. http://togogenome.org/gene/1705394:SP60_RS04020 ^@ http://purl.uniprot.org/uniprot/A0A0M4NIR1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/1705394:SP60_RS05210 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJ63 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/1705394:SP60_RS03515 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS06030 ^@ http://purl.uniprot.org/uniprot/A0A0M4NX21 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/1705394:SP60_RS00265 ^@ http://purl.uniprot.org/uniprot/A0A0M4NVZ9 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/1705394:SP60_RS06020 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU83 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/1705394:SP60_RS00405 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTP5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS05730 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUD7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/1705394:SP60_RS07490 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUJ7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS04125 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU17 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MetA family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS03035 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEG1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1705394:SP60_RS00580 ^@ http://purl.uniprot.org/uniprot/A0A0M4NFZ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS02075 ^@ http://purl.uniprot.org/uniprot/A0A0M4NT42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.|||Belongs to the KdsB family.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS07470 ^@ http://purl.uniprot.org/uniprot/A0A0M4PP51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.|||Cytoplasm|||Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity. http://togogenome.org/gene/1705394:SP60_RS06105 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS07845 ^@ http://purl.uniprot.org/uniprot/A0A0M4PP90 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/1705394:SP60_RS03935 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS07890 ^@ http://purl.uniprot.org/uniprot/A0A0M4NK21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurJ/MviN family.|||Cell inner membrane|||Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.|||Membrane http://togogenome.org/gene/1705394:SP60_RS03910 ^@ http://purl.uniprot.org/uniprot/A0A0M4NTK2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/1705394:SP60_RS01930 ^@ http://purl.uniprot.org/uniprot/A0A0M5LJ23 ^@ Similarity ^@ Belongs to the MlaA family. http://togogenome.org/gene/1705394:SP60_RS03700 ^@ http://purl.uniprot.org/uniprot/A0A0M4P8T0 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/1705394:SP60_RS04540 ^@ http://purl.uniprot.org/uniprot/A0A0M4PPG2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transferase hexapeptide repeat family.|||Cytoplasm|||Homotrimer. http://togogenome.org/gene/1705394:SP60_RS01040 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEJ3 ^@ Function|||Similarity ^@ Belongs to the TrhO family.|||Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs. http://togogenome.org/gene/1705394:SP60_RS06345 ^@ http://purl.uniprot.org/uniprot/A0A0M4PL80 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/1705394:SP60_RS03205 ^@ http://purl.uniprot.org/uniprot/A0A0M5LER7 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/1705394:SP60_RS00825 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTQ8 ^@ Similarity|||Subunit ^@ Belongs to the ALAD family.|||Homooctamer. http://togogenome.org/gene/1705394:SP60_RS01815 ^@ http://purl.uniprot.org/uniprot/A0A0M4NT17 ^@ Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the CobB/CbiA family.|||Belongs to the CobB/CobQ family. CobQ subfamily.|||Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.|||Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.|||The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate. http://togogenome.org/gene/1705394:SP60_RS07620 ^@ http://purl.uniprot.org/uniprot/A0A0M4PP69 ^@ Function|||Similarity ^@ Acts on leucine, isoleucine and valine.|||Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1705394:SP60_RS02475 ^@ http://purl.uniprot.org/uniprot/A0A0M4P8D8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS05475 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXF3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. http://togogenome.org/gene/1705394:SP60_RS07950 ^@ http://purl.uniprot.org/uniprot/A0A0M5LL56 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/1705394:SP60_RS00060 ^@ http://purl.uniprot.org/uniprot/A0A0M4PLU4 ^@ Similarity ^@ Belongs to the UPF0178 family. http://togogenome.org/gene/1705394:SP60_RS05565 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUD1 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/1705394:SP60_RS05465 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJ93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/1705394:SP60_RS02195 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTV3 ^@ Similarity ^@ Belongs to the antibiotic N-acetyltransferase family. http://togogenome.org/gene/1705394:SP60_RS00185 ^@ http://purl.uniprot.org/uniprot/A0A0M4PJE9 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/1705394:SP60_RS07320 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEW7 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/1705394:SP60_RS07250 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXZ1 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/1705394:SP60_RS00880 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEF5 ^@ Similarity ^@ Belongs to the PrpF family. http://togogenome.org/gene/1705394:SP60_RS04760 ^@ http://purl.uniprot.org/uniprot/A0A0M5LER6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-to-5' exoribonuclease specific for small oligoribonucleotides.|||Belongs to the oligoribonuclease family.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS00790 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTX0 ^@ Function|||Similarity ^@ Belongs to the HPPK family.|||Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway. http://togogenome.org/gene/1705394:SP60_RS04220 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS01735 ^@ http://purl.uniprot.org/uniprot/A0A0M4NT09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.|||Membrane http://togogenome.org/gene/1705394:SP60_RS06715 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUA6 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1705394:SP60_RS03680 ^@ http://purl.uniprot.org/uniprot/A0A0M4NTI0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.|||Cytoplasm|||Homotrimer.|||In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/1705394:SP60_RS00835 ^@ http://purl.uniprot.org/uniprot/A0A0M4P7V3 ^@ Caution|||Function|||PTM|||Similarity ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.|||Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS04340 ^@ http://purl.uniprot.org/uniprot/A0A0M4NTP4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/1705394:SP60_RS05470 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU66 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/1705394:SP60_RS05285 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXD3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/1705394:SP60_RS04560 ^@ http://purl.uniprot.org/uniprot/A0A0M4P937 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA polymerase type-A family.|||In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.|||Single-chain monomer with multiple functions. http://togogenome.org/gene/1705394:SP60_RS00805 ^@ http://purl.uniprot.org/uniprot/A0A0M4NVH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Cell membrane|||Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. http://togogenome.org/gene/1705394:SP60_RS05080 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS07020 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJR5 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/1705394:SP60_RS07380 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJW4 ^@ Function|||Similarity ^@ Belongs to the RecO family.|||Involved in DNA repair and RecF pathway recombination. http://togogenome.org/gene/1705394:SP60_RS07495 ^@ http://purl.uniprot.org/uniprot/A0A0M4NI26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS05155 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXV9 ^@ Similarity ^@ Belongs to the UPF0260 family. http://togogenome.org/gene/1705394:SP60_RS07780 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsuA/YedE (TC 9.B.102) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS05330 ^@ http://purl.uniprot.org/uniprot/A0A0M5LL49 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/1705394:SP60_RS02410 ^@ http://purl.uniprot.org/uniprot/A0A0M4NK79 ^@ Function|||Similarity|||Subunit ^@ Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.|||Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.|||Homodimer.|||In the C-terminal section; belongs to the cytidylyltransferase family.|||In the N-terminal section; belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/1705394:SP60_RS05665 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHI3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 1 family.|||Cell membrane|||Membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. http://togogenome.org/gene/1705394:SP60_RS00675 ^@ http://purl.uniprot.org/uniprot/A0A0M4NG06 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1705394:SP60_RS03150 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU46 ^@ Similarity ^@ Belongs to the transcriptional regulatory Fis family. http://togogenome.org/gene/1705394:SP60_RS07100 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the thioredoxin family. DsbE subfamily.|||Cell inner membrane http://togogenome.org/gene/1705394:SP60_RS01455 ^@ http://purl.uniprot.org/uniprot/A0A0M4NG86 ^@ Similarity ^@ Belongs to the YkuD family. http://togogenome.org/gene/1705394:SP60_RS02635 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWM5 ^@ Similarity ^@ Belongs to the fabD family. http://togogenome.org/gene/1705394:SP60_RS00335 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHL7 ^@ Function|||Similarity ^@ Belongs to the peptidase S11 family.|||Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. http://togogenome.org/gene/1705394:SP60_RS01385 ^@ http://purl.uniprot.org/uniprot/A0A0M4P814 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Iojap/RsfS family.|||Cytoplasm|||Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.|||Interacts with ribosomal protein uL14 (rplN). http://togogenome.org/gene/1705394:SP60_RS06095 ^@ http://purl.uniprot.org/uniprot/A0A0M4NX31 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS00150 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTU8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1705394:SP60_RS05480 ^@ http://purl.uniprot.org/uniprot/A0A0M5LET0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thioredoxin family. DsbC subfamily.|||Periplasm|||Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. http://togogenome.org/gene/1705394:SP60_RS08050 ^@ http://purl.uniprot.org/uniprot/A0A0M4NK42 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase T family.|||Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein.|||Homodimer.|||Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis. http://togogenome.org/gene/1705394:SP60_RS07865 ^@ http://purl.uniprot.org/uniprot/A0A0M4NI68 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/1705394:SP60_RS01580 ^@ http://purl.uniprot.org/uniprot/A0A0M4NVP3 ^@ Similarity ^@ Belongs to the alpha-acetolactate decarboxylase family. http://togogenome.org/gene/1705394:SP60_RS03180 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS07140 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHY6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. http://togogenome.org/gene/1705394:SP60_RS05220 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXC5 ^@ Similarity ^@ Belongs to the SIS family. GutQ/KpsF subfamily. http://togogenome.org/gene/1705394:SP60_RS07400 ^@ http://purl.uniprot.org/uniprot/A0A0M4PP44 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. UbiG/COQ3 family.|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/1705394:SP60_RS03880 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWY9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HesB/IscA family.|||Binds 1 iron-sulfur cluster per subunit.|||Homodimer.|||Required for insertion of 4Fe-4S clusters for at least IspG. http://togogenome.org/gene/1705394:SP60_RS05930 ^@ http://purl.uniprot.org/uniprot/A0A0M4PNL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmH family.|||Cytoplasm|||Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. http://togogenome.org/gene/1705394:SP60_RS05585 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWX2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||Cytoplasm|||Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/1705394:SP60_RS06425 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXQ1 ^@ Function|||Similarity ^@ Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). http://togogenome.org/gene/1705394:SP60_RS05825 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUH2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/1705394:SP60_RS03565 ^@ http://purl.uniprot.org/uniprot/A0A0M5LKU0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS03460 ^@ http://purl.uniprot.org/uniprot/A0A0M4P8Q1 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/1705394:SP60_RS05190 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS05115 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKU8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS01670 ^@ http://purl.uniprot.org/uniprot/A0A0M4NT03 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/1705394:SP60_RS01150 ^@ http://purl.uniprot.org/uniprot/A0A0M4PJQ6 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvA family.|||Cytoplasm|||Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.|||Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/1705394:SP60_RS04840 ^@ http://purl.uniprot.org/uniprot/A0A0M4PN90 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. PriA subfamily.|||Component of the primosome.|||Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. http://togogenome.org/gene/1705394:SP60_RS03455 ^@ http://purl.uniprot.org/uniprot/A0A0M4NGX4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thioester dehydratase family. FabA subfamily.|||Cytoplasm|||Homodimer.|||Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. http://togogenome.org/gene/1705394:SP60_RS01030 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTR3 ^@ Similarity ^@ Belongs to the glutaredoxin family. Monothiol subfamily. http://togogenome.org/gene/1705394:SP60_RS03175 ^@ http://purl.uniprot.org/uniprot/A0A0M5LKT1 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/1705394:SP60_RS02615 ^@ http://purl.uniprot.org/uniprot/A0A0M4PK55 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS03090 ^@ http://purl.uniprot.org/uniprot/A0A0M4NGT5 ^@ Function|||Similarity ^@ Belongs to the HPPK family.|||Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway. http://togogenome.org/gene/1705394:SP60_RS01280 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTY6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.|||Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).|||Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS06860 ^@ http://purl.uniprot.org/uniprot/A0A0M4PLB6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.|||Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS04850 ^@ http://purl.uniprot.org/uniprot/A0A0M4NYD3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA(Ile)-lysidine synthase family.|||Cytoplasm|||Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.|||The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding. http://togogenome.org/gene/1705394:SP60_RS00375 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTV6 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/1705394:SP60_RS00495 ^@ http://purl.uniprot.org/uniprot/A0A0M4NVD8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.|||Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS04150 ^@ http://purl.uniprot.org/uniprot/A0A0M4NK94 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/1705394:SP60_RS05295 ^@ http://purl.uniprot.org/uniprot/A0A0M5LJA1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/1705394:SP60_RS04015 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKI6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1705394:SP60_RS03165 ^@ http://purl.uniprot.org/uniprot/A0A0M4NGU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS03335 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKB4 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/1705394:SP60_RS03925 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU71 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit.|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. http://togogenome.org/gene/1705394:SP60_RS05110 ^@ http://purl.uniprot.org/uniprot/A0A0M5LHK7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueA family.|||Cytoplasm|||Monomer.|||Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). http://togogenome.org/gene/1705394:SP60_RS06140 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MreD family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS03820 ^@ http://purl.uniprot.org/uniprot/A0A0M4PMV4 ^@ Function|||Similarity ^@ Belongs to the RecN family.|||May be involved in recombinational repair of damaged DNA. http://togogenome.org/gene/1705394:SP60_RS05045 ^@ http://purl.uniprot.org/uniprot/A0A0M4PPG9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS00740 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTW8 ^@ Cofactor ^@ Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/1705394:SP60_RS01390 ^@ http://purl.uniprot.org/uniprot/A0A0M5LHB9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase RlmH family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. http://togogenome.org/gene/1705394:SP60_RS05365 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWV3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/1705394:SP60_RS06085 ^@ http://purl.uniprot.org/uniprot/A0A0M4PNN7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1705394:SP60_RS05405 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJ85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS00420 ^@ http://purl.uniprot.org/uniprot/A0A0M5LIX7 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/1705394:SP60_RS02325 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTV7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HisA/HisF family.|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/1705394:SP60_RS06815 ^@ http://purl.uniprot.org/uniprot/A0A0M4PNX7 ^@ Similarity ^@ Belongs to the MoaD family. http://togogenome.org/gene/1705394:SP60_RS03010 ^@ http://purl.uniprot.org/uniprot/A0A0M4NTB8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/1705394:SP60_RS01720 ^@ http://purl.uniprot.org/uniprot/A0A0M4PMA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.|||Belongs to the KdsB family.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS03825 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWC5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS01770 ^@ http://purl.uniprot.org/uniprot/A0A0M4NYA8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/1705394:SP60_RS07220 ^@ http://purl.uniprot.org/uniprot/A0A0M4PAF7 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/1705394:SP60_RS03795 ^@ http://purl.uniprot.org/uniprot/A0A0M4NIP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Membrane http://togogenome.org/gene/1705394:SP60_RS06530 ^@ http://purl.uniprot.org/uniprot/A0A0M4NUB5 ^@ Cofactor|||Similarity ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit. http://togogenome.org/gene/1705394:SP60_RS01180 ^@ http://purl.uniprot.org/uniprot/A0A0M4PM52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TrkH potassium transport family.|||Cell inner membrane|||Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.|||Membrane http://togogenome.org/gene/1705394:SP60_RS04475 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU29 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/1705394:SP60_RS00285 ^@ http://purl.uniprot.org/uniprot/A0A0M4PPD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS05260 ^@ http://purl.uniprot.org/uniprot/A0A0M4P9A8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1705394:SP60_RS07870 ^@ http://purl.uniprot.org/uniprot/A0A0M4PA46 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/1705394:SP60_RS01080 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTR5 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/1705394:SP60_RS02990 ^@ http://purl.uniprot.org/uniprot/A0A0M4PMN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS00025 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTU4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TolB family.|||Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.|||Periplasm|||The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer. http://togogenome.org/gene/1705394:SP60_RS03100 ^@ http://purl.uniprot.org/uniprot/A0A0M5LKZ5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsY family.|||Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Probably interacts with PlsX. http://togogenome.org/gene/1705394:SP60_RS07180 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEW9 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/1705394:SP60_RS03070 ^@ http://purl.uniprot.org/uniprot/A0A0M4NW42 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/1705394:SP60_RS08170 ^@ http://purl.uniprot.org/uniprot/A0A0M5LES8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS00380 ^@ http://purl.uniprot.org/uniprot/A0A0M4NFW2 ^@ Cofactor|||Similarity ^@ Belongs to the glyoxalase I family.|||Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits. http://togogenome.org/gene/1705394:SP60_RS05760 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS01250 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Cell membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS08015 ^@ http://purl.uniprot.org/uniprot/A0A0M4PA67 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. HflK subfamily.|||HflC and HflK could encode or regulate a protease.|||HflC and HflK may interact to form a multimeric complex.|||Membrane http://togogenome.org/gene/1705394:SP60_RS07905 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEY3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the transferase hexapeptide repeat family. LpxD subfamily.|||Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.|||Homotrimer. http://togogenome.org/gene/1705394:SP60_RS01295 ^@ http://purl.uniprot.org/uniprot/A0A0M5LKN9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS05735 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHJ0 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS06555 ^@ http://purl.uniprot.org/uniprot/A0A0M5LHN9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Fur family.|||Binds 1 Mn(2+) or Fe(2+) ion per subunit.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS01070 ^@ http://purl.uniprot.org/uniprot/A0A0M4P7Y0 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RlmN family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.|||Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity. http://togogenome.org/gene/1705394:SP60_RS06260 ^@ http://purl.uniprot.org/uniprot/A0A0M4PL79 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/1705394:SP60_RS06790 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUH3 ^@ Similarity ^@ Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. http://togogenome.org/gene/1705394:SP60_RS04775 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/1705394:SP60_RS04905 ^@ http://purl.uniprot.org/uniprot/A0A0M4PN98 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Cell inner membrane|||Homodimer.|||Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.|||The transmembrane domain is a dimerization domain. http://togogenome.org/gene/1705394:SP60_RS01995 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEI1 ^@ Similarity ^@ Belongs to the GPI family. http://togogenome.org/gene/1705394:SP60_RS07235 ^@ http://purl.uniprot.org/uniprot/A0A0M4PLF8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS00135 ^@ http://purl.uniprot.org/uniprot/A0A0M4NVY7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.|||Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers. http://togogenome.org/gene/1705394:SP60_RS03605 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWA4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family. YceF subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/1705394:SP60_RS05915 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJD7 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/1705394:SP60_RS02510 ^@ http://purl.uniprot.org/uniprot/A0A0M4PMI9 ^@ Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 2 family. http://togogenome.org/gene/1705394:SP60_RS05315 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHE3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/1705394:SP60_RS03690 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU62 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/1705394:SP60_RS01820 ^@ http://purl.uniprot.org/uniprot/A0A0M4NGD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NrfD family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS03060 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/1705394:SP60_RS00460 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTP7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/1705394:SP60_RS07445 ^@ http://purl.uniprot.org/uniprot/A0A0M4PLI1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS03155 ^@ http://purl.uniprot.org/uniprot/A0A0M4NW50 ^@ Domain|||Similarity ^@ Belongs to the PurH family.|||The IMP cyclohydrolase activity resides in the N-terminal region. http://togogenome.org/gene/1705394:SP60_RS07275 ^@ http://purl.uniprot.org/uniprot/A0A0M4NUJ0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS07085 ^@ http://purl.uniprot.org/uniprot/A0A0M4PLE2 ^@ Similarity ^@ Belongs to the KAE1 / TsaD family. TsaB subfamily. http://togogenome.org/gene/1705394:SP60_RS03360 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PilY1 family.|||Fimbrium http://togogenome.org/gene/1705394:SP60_RS00780 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHS9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pantothenate synthetase family.|||Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.|||Cytoplasm|||Homodimer.|||The reaction proceeds by a bi uni uni bi ping pong mechanism. http://togogenome.org/gene/1705394:SP60_RS06225 ^@ http://purl.uniprot.org/uniprot/A0A0M4NX46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Cytoplasm|||In the N-terminal section; belongs to the lyase 1 family. Argininosuccinate lyase subfamily. http://togogenome.org/gene/1705394:SP60_RS04575 ^@ http://purl.uniprot.org/uniprot/A0A0M4PKP8 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the thiamine-phosphate synthase family.|||Binds 1 Mg(2+) ion per subunit.|||Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1705394:SP60_RS03735 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU03 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RnpA family.|||Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.|||RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. http://togogenome.org/gene/1705394:SP60_RS01715 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEN5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS06570 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXR8 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/1705394:SP60_RS03395 ^@ http://purl.uniprot.org/uniprot/A0A0M4P8P3 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/1705394:SP60_RS05625 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJA7 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/1705394:SP60_RS00205 ^@ http://purl.uniprot.org/uniprot/A0A0M5LEJ5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 90 family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Molecular chaperone. Has ATPase activity. http://togogenome.org/gene/1705394:SP60_RS06420 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJJ9 ^@ Similarity|||Subunit ^@ Belongs to the IspF family.|||Homotrimer. http://togogenome.org/gene/1705394:SP60_RS06240 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHP7 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/1705394:SP60_RS04885 ^@ http://purl.uniprot.org/uniprot/A0A0M4NJ03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane http://togogenome.org/gene/1705394:SP60_RS06050 ^@ http://purl.uniprot.org/uniprot/A0A0M4P9J8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1705394:SP60_RS05905 ^@ http://purl.uniprot.org/uniprot/A0A0M4PL50 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/1705394:SP60_RS07370 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUJ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/1705394:SP60_RS02640 ^@ http://purl.uniprot.org/uniprot/A0A0M5LJ38 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/1705394:SP60_RS07055 ^@ http://purl.uniprot.org/uniprot/A0A0M4NUG8 ^@ Function|||Similarity ^@ Belongs to the alanine racemase family.|||Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. http://togogenome.org/gene/1705394:SP60_RS01660 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTZ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ThiG family.|||Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.|||Cytoplasm|||Homotetramer. Forms heterodimers with either ThiH or ThiS. http://togogenome.org/gene/1705394:SP60_RS01270 ^@ http://purl.uniprot.org/uniprot/A0A0M4NVL5 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/1705394:SP60_RS07365 ^@ http://purl.uniprot.org/uniprot/A0A0M4PLH3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribonuclease III family.|||Cytoplasm|||Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS00215 ^@ http://purl.uniprot.org/uniprot/A0A0M4NV99 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/1705394:SP60_RS02665 ^@ http://purl.uniprot.org/uniprot/A0A0M4NGP2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/1705394:SP60_RS05250 ^@ http://purl.uniprot.org/uniprot/A0A0M4NTX7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1705394:SP60_RS07925 ^@ http://purl.uniprot.org/uniprot/A0A0M4NUQ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the diaminopimelate epimerase family.|||Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS01215 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTY4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/1705394:SP60_RS05300 ^@ http://purl.uniprot.org/uniprot/A0A0M4PND7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1705394:SP60_RS01255 ^@ http://purl.uniprot.org/uniprot/A0A0M3TTS1 ^@ Function|||Similarity ^@ Belongs to the SELO family.|||Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). http://togogenome.org/gene/1705394:SP60_RS03075 ^@ http://purl.uniprot.org/uniprot/A0A0M4NTC6 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS05055 ^@ http://purl.uniprot.org/uniprot/A0A0M3TUB2 ^@ Similarity ^@ Belongs to the DNA polymerase HolA subunit family. http://togogenome.org/gene/1705394:SP60_RS02345 ^@ http://purl.uniprot.org/uniprot/A0A0M4PK31 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/1705394:SP60_RS05660 ^@ http://purl.uniprot.org/uniprot/A0A0M4NU27 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the complex I 75 kDa subunit family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/1705394:SP60_RS03340 ^@ http://purl.uniprot.org/uniprot/A0A0M4NIJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial secretin family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/1705394:SP60_RS06820 ^@ http://purl.uniprot.org/uniprot/A0A0M4NXB4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Monomer and homodimer. http://togogenome.org/gene/1705394:SP60_RS07285 ^@ http://purl.uniprot.org/uniprot/A0A0M4P9Y1 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/1705394:SP60_RS01230 ^@ http://purl.uniprot.org/uniprot/A0A0M4NHX3 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/1705394:SP60_RS05650 ^@ http://purl.uniprot.org/uniprot/A0A0M4NWY0 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/1705394:SP60_RS04325 ^@ http://purl.uniprot.org/uniprot/A0A0M3TU86 ^@ Similarity ^@ Belongs to the prokaryotic GSH synthase family. http://togogenome.org/gene/1705394:SP60_RS06835 ^@ http://purl.uniprot.org/uniprot/A0A0M4NUE2 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MobA family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.|||Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.