http://togogenome.org/gene/188937:MA_RS07230 ^@ http://purl.uniprot.org/uniprot/Q8TQZ1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the transcriptional regulatory CopG/NikR family.|||Binds 1 nickel ion per subunit.|||Transcriptional regulator. http://togogenome.org/gene/188937:MA_RS08680 ^@ http://purl.uniprot.org/uniprot/Q8TQ77 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS16720 ^@ http://purl.uniprot.org/uniprot/Q8TL41 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. http://togogenome.org/gene/188937:MA_RS15790 ^@ http://purl.uniprot.org/uniprot/Q8TLM0 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/188937:MA_RS21700 ^@ http://purl.uniprot.org/uniprot/Q8TIJ0 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. http://togogenome.org/gene/188937:MA_RS11855 ^@ http://purl.uniprot.org/uniprot/Q8TNK0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS03105 ^@ http://purl.uniprot.org/uniprot/Q8TT47 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/188937:MA_RS18985 ^@ http://purl.uniprot.org/uniprot/Q8TJY4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS02660 ^@ http://purl.uniprot.org/uniprot/Q8TTC6 ^@ Similarity ^@ Belongs to the UPF0228 family. http://togogenome.org/gene/188937:MA_RS00125 ^@ http://purl.uniprot.org/uniprot/Q8TUP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Membrane http://togogenome.org/gene/188937:MA_RS18560 ^@ http://purl.uniprot.org/uniprot/Q8TK62 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CbiM family.|||Cell membrane|||Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.|||Membrane|||Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. http://togogenome.org/gene/188937:MA_RS04845 ^@ http://purl.uniprot.org/uniprot/Q8TS71 ^@ Function|||Similarity ^@ Acts as a methyl group carrier between MtbB and MtbA.|||Belongs to the methylamine corrinoid protein family. http://togogenome.org/gene/188937:MA_RS18230 ^@ http://purl.uniprot.org/uniprot/Q8TKC0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/188937:MA_RS03780 ^@ http://purl.uniprot.org/uniprot/Q8TSS3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SepCysS family.|||Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).|||Homodimer. Interacts with SepRS. http://togogenome.org/gene/188937:MA_RS20215 ^@ http://purl.uniprot.org/uniprot/Q8TJB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/188937:MA_RS04265 ^@ http://purl.uniprot.org/uniprot/Q8TSH7 ^@ Function|||Similarity ^@ Belongs to the LDH/MDH superfamily.|||Catalyzes the reversible oxidation of malate to oxaloacetate. http://togogenome.org/gene/188937:MA_RS19245 ^@ http://purl.uniprot.org/uniprot/Q8TJT3 ^@ Function|||Similarity ^@ Belongs to the GTP-dependent DPCK family.|||Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). http://togogenome.org/gene/188937:MA_RS20265 ^@ http://purl.uniprot.org/uniprot/Q8TJA2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/188937:MA_RS03340 ^@ http://purl.uniprot.org/uniprot/Q8TT07 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/188937:MA_RS00385 ^@ http://purl.uniprot.org/uniprot/Q8TUJ2 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/188937:MA_RS08970 ^@ http://purl.uniprot.org/uniprot/Q8TQ25 ^@ Cofactor|||Function|||Subunit ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/188937:MA_RS17990 ^@ http://purl.uniprot.org/uniprot/Q8TKG2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/188937:MA_RS18915 ^@ http://purl.uniprot.org/uniprot/Q8TJZ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NifD/NifK/NifE/NifN family.|||Homodimer or monomer (By similarity). The Ni-sirohydrochlorin a,c-diamide reductive cyclase complex is composed of a NifH homolog component CfbC and a NifD homolog component CfbD (PubMed:27846569).|||Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes both the six-electron reduction of the tetrahydroporphyrin ring system and the gamma-lactamization of the c-acetamide side chain of Ni-sirohydrochlorin a,c-diamide to yield 15,17(3)-seco-F430-17(3)-acid (seco-F430), the last intermediate in the biosynthesis of the coenzyme F430. http://togogenome.org/gene/188937:MA_RS02730 ^@ http://purl.uniprot.org/uniprot/Q8TTB4 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. http://togogenome.org/gene/188937:MA_RS21190 ^@ http://purl.uniprot.org/uniprot/Q8TIT1 ^@ Domain|||Function|||Similarity ^@ Belongs to the Nre family.|||Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.|||Involved in DNA damage repair. http://togogenome.org/gene/188937:MA_RS13800 ^@ http://purl.uniprot.org/uniprot/Q8TMK7 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/188937:MA_RS23825 ^@ http://purl.uniprot.org/uniprot/Q8THE7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS22635 ^@ http://purl.uniprot.org/uniprot/Q8TI23 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/188937:MA_RS01115 ^@ http://purl.uniprot.org/uniprot/Q8TU65 ^@ Function|||Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. http://togogenome.org/gene/188937:MA_RS07665 ^@ http://purl.uniprot.org/uniprot/Q8TQR3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/188937:MA_RS19435 ^@ http://purl.uniprot.org/uniprot/Q8TJQ0 ^@ Function|||Similarity ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. http://togogenome.org/gene/188937:MA_RS01580 ^@ http://purl.uniprot.org/uniprot/Q8TTX7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS01985 ^@ http://purl.uniprot.org/uniprot/Q8TTP7 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.|||Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction proceeds via a cis-phosphoenolate intermediate. http://togogenome.org/gene/188937:MA_RS04575 ^@ http://purl.uniprot.org/uniprot/Q8TSB9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS08200 ^@ http://purl.uniprot.org/uniprot/Q8TH29 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/188937:MA_RS12645 ^@ http://purl.uniprot.org/uniprot/Q8TN58 ^@ Function|||Subcellular Location Annotation ^@ F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||Membrane http://togogenome.org/gene/188937:MA_RS22660 ^@ http://purl.uniprot.org/uniprot/Q8TI20 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS10455 ^@ http://purl.uniprot.org/uniprot/Q8TPA6 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.|||Calcium transport is inhibited by Na(+), K(+), Li(+), Mg(2+) or Mn(2+).|||Catalyzes Na(+)/Ca(2+) exchange. The transport is electrogenic with a likely stoichiometry of 3 or more Na(+) for each Ca(2+). Is K(+)-independent.|||Cell membrane http://togogenome.org/gene/188937:MA_RS11650 ^@ http://purl.uniprot.org/uniprot/Q8TNN7 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/188937:MA_RS05975 ^@ http://purl.uniprot.org/uniprot/Q8TRM8 ^@ Similarity ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. http://togogenome.org/gene/188937:MA_RS00205 ^@ http://purl.uniprot.org/uniprot/Q8TUM6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TYW1 family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).|||Cytoplasm|||Monomer. http://togogenome.org/gene/188937:MA_RS00930 ^@ http://purl.uniprot.org/uniprot/Q8TUA2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/188937:MA_RS03065 ^@ http://purl.uniprot.org/uniprot/P58886 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrK family.|||Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit.|||Heterotetramer of 2 PyrK and 2 PyrD type B subunits.|||Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). http://togogenome.org/gene/188937:MA_RS18425 ^@ http://purl.uniprot.org/uniprot/Q8TK87 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/188937:MA_RS16615 ^@ http://purl.uniprot.org/uniprot/Q8TL61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAK/KUP transporter (TC 2.A.72) family.|||Cell membrane|||Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter. http://togogenome.org/gene/188937:MA_RS01435 ^@ http://purl.uniprot.org/uniprot/Q8TU05 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrG family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/188937:MA_RS21200 ^@ http://purl.uniprot.org/uniprot/Q8TIS9 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/188937:MA_RS16690 ^@ http://purl.uniprot.org/uniprot/Q8TL47 ^@ Similarity ^@ Belongs to the snRNP Sm proteins family. http://togogenome.org/gene/188937:MA_RS22255 ^@ http://purl.uniprot.org/uniprot/Q8TI94 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/188937:MA_RS24635 ^@ http://purl.uniprot.org/uniprot/Q8TMH6 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/188937:MA_RS05610 ^@ http://purl.uniprot.org/uniprot/Q8TRU4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/188937:MA_RS10950 ^@ http://purl.uniprot.org/uniprot/Q8TP17 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS18905 ^@ http://purl.uniprot.org/uniprot/Q8TK00 ^@ Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the CobB/CbiA family.|||Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source (Potential). Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation (PubMed:27846569). Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source (PubMed:27846569).|||Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.|||The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate. http://togogenome.org/gene/188937:MA_RS22955 ^@ http://purl.uniprot.org/uniprot/F1SVG6 ^@ Similarity ^@ Belongs to the methylamine corrinoid protein family. http://togogenome.org/gene/188937:MA_RS01375 ^@ http://purl.uniprot.org/uniprot/Q8TH26 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/188937:MA_RS15875 ^@ http://purl.uniprot.org/uniprot/Q8TLK5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/188937:MA_RS10785 ^@ http://purl.uniprot.org/uniprot/Q8TP43 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS18690 ^@ http://purl.uniprot.org/uniprot/Q8TK38 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS23180 ^@ http://purl.uniprot.org/uniprot/Q8THS6 ^@ Function|||Similarity ^@ Belongs to the MfnB family.|||Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). http://togogenome.org/gene/188937:MA_RS01265 ^@ http://purl.uniprot.org/uniprot/Q8TU38 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/188937:MA_RS03160 ^@ http://purl.uniprot.org/uniprot/Q8TT38 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/188937:MA_RS10955 ^@ http://purl.uniprot.org/uniprot/Q8TP16 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS01540 ^@ http://purl.uniprot.org/uniprot/Q8TTY5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 4 family.|||Binds 1 zinc ion per subunit.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/188937:MA_RS04515 ^@ http://purl.uniprot.org/uniprot/Q8TSD1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS05275 ^@ http://purl.uniprot.org/uniprot/Q8TRZ9 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/188937:MA_RS12580 ^@ http://purl.uniprot.org/uniprot/Q8TN69 ^@ Function|||Similarity ^@ Acts as a methyl group carrier between MtbB and MtbA.|||Belongs to the methylamine corrinoid protein family. http://togogenome.org/gene/188937:MA_RS05705 ^@ http://purl.uniprot.org/uniprot/Q8TRS5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/188937:MA_RS19440 ^@ http://purl.uniprot.org/uniprot/Q8TJP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS20550 ^@ http://purl.uniprot.org/uniprot/Q8TJ50 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro. http://togogenome.org/gene/188937:MA_RS03725 ^@ http://purl.uniprot.org/uniprot/Q8TST4 ^@ Caution|||Function|||Similarity ^@ Belongs to the UbiX/PAD1 family.|||Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/188937:MA_RS06285 ^@ http://purl.uniprot.org/uniprot/Q8TRH1 ^@ Similarity ^@ Belongs to the NifD/NifK/NifE/NifN family. http://togogenome.org/gene/188937:MA_RS05045 ^@ http://purl.uniprot.org/uniprot/Q8TS37 ^@ Function|||Similarity|||Subunit ^@ Belongs to the OMP decarboxylase family. Type 1 subfamily.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).|||Homodimer. http://togogenome.org/gene/188937:MA_RS24170 ^@ http://purl.uniprot.org/uniprot/Q8TH90 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeosine synthase type 1 family.|||Forms a robust complex with the archaeosine synthase beta subunit RaSEA. Formation of this complex highly increases lysine transfer activity (PubMed:31740832). The complex likely consists of an alpha(2)beta(2) heterotetrameric structure (By similarity).|||Functions in the biosynthesis of archaeosine, a modified nucleoside present in the dihydrouridine loop (D-loop) of archaeal tRNAs. Catalyzes the addition of L-lysine to the cyano group of 7-cyano-7-deazaguanine (preQ0)-modified tRNAs at position 15, to generate q0kN15-tRNA, a q0N lysine adduct identified as 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine. http://togogenome.org/gene/188937:MA_RS07310 ^@ http://purl.uniprot.org/uniprot/Q8TQX8 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.|||Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.|||Homotrimer. http://togogenome.org/gene/188937:MA_RS22330 ^@ http://purl.uniprot.org/uniprot/Q8TI79 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/188937:MA_RS13100 ^@ http://purl.uniprot.org/uniprot/P58863 ^@ Similarity ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/188937:MA_RS19460 ^@ http://purl.uniprot.org/uniprot/Q8TJP6 ^@ Cofactor ^@ Binds 2 irons ions per subunit via 4 cysteine residues per iron. http://togogenome.org/gene/188937:MA_RS16330 ^@ http://purl.uniprot.org/uniprot/Q8TLB4 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/188937:MA_RS05660 ^@ http://purl.uniprot.org/uniprot/Q8TRT4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/188937:MA_RS07900 ^@ http://purl.uniprot.org/uniprot/Q8TQL9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Cytoplasm|||Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.|||Part of the 50S ribosomal subunit. Probably part of the RNase P complex. http://togogenome.org/gene/188937:MA_RS05675 ^@ http://purl.uniprot.org/uniprot/Q8TRT1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/188937:MA_RS23555 ^@ http://purl.uniprot.org/uniprot/Q8THJ8 ^@ Function ^@ Protects DNA against thermal denaturation and modulates transcription. http://togogenome.org/gene/188937:MA_RS04995 ^@ http://purl.uniprot.org/uniprot/Q8TS44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.|||Cell membrane|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/188937:MA_RS05335 ^@ http://purl.uniprot.org/uniprot/Q8TRZ1 ^@ Similarity ^@ Belongs to the MscS (TC 1.A.23) family. http://togogenome.org/gene/188937:MA_RS03115 ^@ http://purl.uniprot.org/uniprot/Q8TT45 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) per subunit. http://togogenome.org/gene/188937:MA_RS22550 ^@ http://purl.uniprot.org/uniprot/Q8TI38 ^@ Similarity ^@ Belongs to the SAM hydrolase / SAM-dependent halogenase family. http://togogenome.org/gene/188937:MA_RS01715 ^@ http://purl.uniprot.org/uniprot/Q8TTV2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS00815 ^@ http://purl.uniprot.org/uniprot/Q8TUC0 ^@ Cofactor|||Disruption Phenotype|||Function|||Similarity ^@ Belongs to the PylC family.|||Binds 2 magnesium ions per subunit.|||Cells lacking this gene are unable to translate UAG as pyrrolysine, and do not produce pyrrolysine.|||Is required for the biosynthesis of pyrrolysine (PubMed:17204561, PubMed:21455182). Catalyzes the ATP-dependent ligation between (3R)-3-methyl-D-ornithine and L-lysine, leading to (3R)-3-methyl-D-ornithyl-N6-L-lysine (PubMed:21455182). http://togogenome.org/gene/188937:MA_RS08030 ^@ http://purl.uniprot.org/uniprot/Q8TQJ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS02725 ^@ http://purl.uniprot.org/uniprot/Q8TTB5 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/188937:MA_RS01460 ^@ http://purl.uniprot.org/uniprot/Q8TU00 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrD family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/188937:MA_RS00555 ^@ http://purl.uniprot.org/uniprot/Q8TUG2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. http://togogenome.org/gene/188937:MA_RS10960 ^@ http://purl.uniprot.org/uniprot/Q8TP15 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane http://togogenome.org/gene/188937:MA_RS11450 ^@ http://purl.uniprot.org/uniprot/Q8TNS3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS01450 ^@ http://purl.uniprot.org/uniprot/Q8TU02 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrB family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/188937:MA_RS00750 ^@ http://purl.uniprot.org/uniprot/Q8TUC6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS15680 ^@ http://purl.uniprot.org/uniprot/Q8TLP4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/188937:MA_RS04735 ^@ http://purl.uniprot.org/uniprot/Q8TS91 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/188937:MA_RS03800 ^@ http://purl.uniprot.org/uniprot/Q8TSR9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/188937:MA_RS09380 ^@ http://purl.uniprot.org/uniprot/Q8TPV0 ^@ Similarity|||Subunit ^@ Belongs to the MtrH family.|||May be part of a complex composed of 3 subunits; MtxA, MtxH and MtxX. http://togogenome.org/gene/188937:MA_RS17680 ^@ http://purl.uniprot.org/uniprot/Q8TKL5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/188937:MA_RS10485 ^@ http://purl.uniprot.org/uniprot/Q8TPA0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Editing domain AlaX-M subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Functions in trans to edit the amino acid moiety from mischarged charged tRNA(Ala). http://togogenome.org/gene/188937:MA_RS20275 ^@ http://purl.uniprot.org/uniprot/Q8TJA1 ^@ Similarity ^@ Belongs to the UPF0284 family. http://togogenome.org/gene/188937:MA_RS18100 ^@ http://purl.uniprot.org/uniprot/Q8TKE1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS08400 ^@ http://purl.uniprot.org/uniprot/F1SVI3 ^@ Similarity ^@ Belongs to the methylamine corrinoid protein family. http://togogenome.org/gene/188937:MA_RS06510 ^@ http://purl.uniprot.org/uniprot/P61929 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/188937:MA_RS02415 ^@ http://purl.uniprot.org/uniprot/Q8TTH3 ^@ Function|||Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 6 (HDG) family.|||Excises hypoxanthine, a deamination product of adenine, from double-stranded DNA. Acts on double-stranded DNA containing G/I, T/I, A/I and C/I base pairs, but not on single-stranded inosine-containing DNA. Has also minor xanthine DNA glycosylase activity. Lacks any detectable uracil-DNA glycosylase activity. http://togogenome.org/gene/188937:MA_RS01170 ^@ http://purl.uniprot.org/uniprot/Q8TU56 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family. Long subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Feedback inhibited by histidine. http://togogenome.org/gene/188937:MA_RS02305 ^@ http://purl.uniprot.org/uniprot/Q8TGX9 ^@ Function|||Similarity ^@ Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/188937:MA_RS06335 ^@ http://purl.uniprot.org/uniprot/Q8TRG2 ^@ Similarity ^@ Belongs to the NifD/NifK/NifE/NifN family. http://togogenome.org/gene/188937:MA_RS21480 ^@ http://purl.uniprot.org/uniprot/Q8TIM8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/188937:MA_RS01495 ^@ http://purl.uniprot.org/uniprot/Q8TTZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/188937:MA_RS17605 ^@ http://purl.uniprot.org/uniprot/Q8TKM8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer. http://togogenome.org/gene/188937:MA_RS21925 ^@ http://purl.uniprot.org/uniprot/Q8TIF2 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/188937:MA_RS20910 ^@ http://purl.uniprot.org/uniprot/Q8TIY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/188937:MA_RS14175 ^@ http://purl.uniprot.org/uniprot/Q8TMF0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS19235 ^@ http://purl.uniprot.org/uniprot/Q8TJT5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.|||Nucleus|||Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure. http://togogenome.org/gene/188937:MA_RS04645 ^@ http://purl.uniprot.org/uniprot/Q8TSA6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. http://togogenome.org/gene/188937:MA_RS06075 ^@ http://purl.uniprot.org/uniprot/Q8TRK8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/188937:MA_RS17360 ^@ http://purl.uniprot.org/uniprot/Q8TKS2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/188937:MA_RS02185 ^@ http://purl.uniprot.org/uniprot/Q8TTL3 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/188937:MA_RS05255 ^@ http://purl.uniprot.org/uniprot/Q8TS03 ^@ Similarity ^@ Belongs to the Fur family. http://togogenome.org/gene/188937:MA_RS17050 ^@ http://purl.uniprot.org/uniprot/Q8TKX5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RimK family. MptN subfamily.|||Binds 2 magnesium or manganese ions per subunit.|||Catalyzes the ATP or GTP-dependent addition of one L-glutamate molecule to tetrahydromethanopterin, producing tetrahydrosarcinapterin.|||Homodimer. http://togogenome.org/gene/188937:MA_RS19880 ^@ http://purl.uniprot.org/uniprot/Q8TJG8 ^@ Subcellular Location Annotation ^@ Encapsulin nanocompartment http://togogenome.org/gene/188937:MA_RS00045 ^@ http://purl.uniprot.org/uniprot/Q8TUQ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FTR family.|||Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/188937:MA_RS18910 ^@ http://purl.uniprot.org/uniprot/Q8TJZ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NifH/BchL/ChlL family.|||Homodimer (By similarity). The Ni-sirohydrochlorin a,c-diamide reductive cyclase complex is composed of a NifH homolog component CfbC and a NifD homolog component CfbD (PubMed:27846569).|||Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes both the six-electron reduction of the tetrahydroporphyrin ring system and the gamma-lactamization of the c-acetamide side chain of Ni-sirohydrochlorin a,c-diamide to yield 15,17(3)-seco-F430-17(3)-acid (seco-F430), the last intermediate in the biosynthesis of the coenzyme F430. http://togogenome.org/gene/188937:MA_RS16915 ^@ http://purl.uniprot.org/uniprot/Q8TL02 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aTrm56 family.|||Cytoplasm|||Homodimer.|||Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs. http://togogenome.org/gene/188937:MA_RS08570 ^@ http://purl.uniprot.org/uniprot/Q8TQ98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/188937:MA_RS14750 ^@ http://purl.uniprot.org/uniprot/Q8TM55 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/188937:MA_RS03760 ^@ http://purl.uniprot.org/uniprot/Q8TSS7 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family.|||Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). http://togogenome.org/gene/188937:MA_RS11135 ^@ http://purl.uniprot.org/uniprot/Q8TNY3 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/188937:MA_RS03205 ^@ http://purl.uniprot.org/uniprot/Q8TT29 ^@ Function|||Similarity ^@ Belongs to the TFIIB family.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/188937:MA_RS06000 ^@ http://purl.uniprot.org/uniprot/Q8TRM3 ^@ Similarity ^@ Belongs to the FBPase class 2 family. http://togogenome.org/gene/188937:MA_RS18895 ^@ http://purl.uniprot.org/uniprot/Q8TGX1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.|||Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity).|||Homodimer. http://togogenome.org/gene/188937:MA_RS00120 ^@ http://purl.uniprot.org/uniprot/Q8TUP1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS21695 ^@ http://purl.uniprot.org/uniprot/Q8TIJ1 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. http://togogenome.org/gene/188937:MA_RS21180 ^@ http://purl.uniprot.org/uniprot/Q8TIT3 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/188937:MA_RS04895 ^@ http://purl.uniprot.org/uniprot/Q8TS63 ^@ Function ^@ Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin. http://togogenome.org/gene/188937:MA_RS05645 ^@ http://purl.uniprot.org/uniprot/Q8TRT7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges. http://togogenome.org/gene/188937:MA_RS06325 ^@ http://purl.uniprot.org/uniprot/Q8TRG4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NifD/NifK/NifE/NifN family.|||Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).|||This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation. http://togogenome.org/gene/188937:MA_RS13710 ^@ http://purl.uniprot.org/uniprot/Q8TMM4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS11145 ^@ http://purl.uniprot.org/uniprot/Q8TNY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/188937:MA_RS09775 ^@ http://purl.uniprot.org/uniprot/Q8TPN2 ^@ Similarity ^@ Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/188937:MA_RS02385 ^@ http://purl.uniprot.org/uniprot/F1SVM3 ^@ Similarity ^@ Belongs to the methylamine corrinoid protein family. http://togogenome.org/gene/188937:MA_RS09270 ^@ http://purl.uniprot.org/uniprot/Q8TPX0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/188937:MA_RS00070 ^@ http://purl.uniprot.org/uniprot/Q8TUQ0 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CheB family.|||Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.|||Cytoplasm|||Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.|||Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity. http://togogenome.org/gene/188937:MA_RS19385 ^@ http://purl.uniprot.org/uniprot/Q8TJQ9 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/188937:MA_RS04935 ^@ http://purl.uniprot.org/uniprot/Q8TS56 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/188937:MA_RS05620 ^@ http://purl.uniprot.org/uniprot/Q8TRU2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/188937:MA_RS20460 ^@ http://purl.uniprot.org/uniprot/Q8TJ69 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS13905 ^@ http://purl.uniprot.org/uniprot/Q8TMJ0 ^@ Function|||Similarity ^@ Belongs to the PEP-utilizing enzyme family.|||Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. http://togogenome.org/gene/188937:MA_RS05950 ^@ http://purl.uniprot.org/uniprot/Q8TRN3 ^@ Similarity ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. http://togogenome.org/gene/188937:MA_RS09460 ^@ http://purl.uniprot.org/uniprot/Q8TPT8 ^@ Similarity ^@ Belongs to the DMRL synthase family. http://togogenome.org/gene/188937:MA_RS01415 ^@ http://purl.uniprot.org/uniprot/Q8TU10 ^@ Function|||Similarity ^@ Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).|||Belongs to the archease family. http://togogenome.org/gene/188937:MA_RS16090 ^@ http://purl.uniprot.org/uniprot/Q8TLF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Archaeal flagellum|||Belongs to the archaeal flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella. http://togogenome.org/gene/188937:MA_RS20895 ^@ http://purl.uniprot.org/uniprot/Q8TIY4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS12650 ^@ http://purl.uniprot.org/uniprot/Q8TN57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane http://togogenome.org/gene/188937:MA_RS05640 ^@ http://purl.uniprot.org/uniprot/Q8TRT8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/188937:MA_RS03430 ^@ http://purl.uniprot.org/uniprot/Q8TSZ1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.|||Monomer.|||The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity. http://togogenome.org/gene/188937:MA_RS05005 ^@ http://purl.uniprot.org/uniprot/Q8TS42 ^@ Function|||Similarity ^@ Belongs to the HARP family.|||RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. http://togogenome.org/gene/188937:MA_RS00005 ^@ http://purl.uniprot.org/uniprot/Q8TUR2 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/188937:MA_RS18555 ^@ http://purl.uniprot.org/uniprot/Q8TK63 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CbiN family.|||Cell membrane|||Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. http://togogenome.org/gene/188937:MA_RS00025 ^@ http://purl.uniprot.org/uniprot/Q8TUQ9 ^@ Function|||Similarity ^@ Belongs to the group II decarboxylase family. MfnA subfamily.|||Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis. http://togogenome.org/gene/188937:MA_RS21395 ^@ http://purl.uniprot.org/uniprot/Q9HHA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyl phosphate reductase family.|||Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS01085 ^@ http://purl.uniprot.org/uniprot/Q8TU71 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/188937:MA_RS22620 ^@ http://purl.uniprot.org/uniprot/Q8TI26 ^@ Function|||Similarity ^@ Belongs to the TBP family.|||General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. http://togogenome.org/gene/188937:MA_RS04985 ^@ http://purl.uniprot.org/uniprot/Q8TS46 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the quinolinate synthase family. Type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS06150 ^@ http://purl.uniprot.org/uniprot/Q8TRJ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS12990 ^@ http://purl.uniprot.org/uniprot/Q8TMZ6 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/188937:MA_RS05725 ^@ http://purl.uniprot.org/uniprot/Q8TRS1 ^@ Similarity ^@ Belongs to the gamma-class carbonic anhydrase family. http://togogenome.org/gene/188937:MA_RS01075 ^@ http://purl.uniprot.org/uniprot/Q8TU73 ^@ Similarity ^@ Belongs to the UPF0166 family. http://togogenome.org/gene/188937:MA_RS12000 ^@ http://purl.uniprot.org/uniprot/Q8TNH5 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. http://togogenome.org/gene/188937:MA_RS16920 ^@ http://purl.uniprot.org/uniprot/Q8TL01 ^@ Function|||Similarity ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.|||Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. http://togogenome.org/gene/188937:MA_RS07510 ^@ http://purl.uniprot.org/uniprot/Q8TQU2 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase Pus10 family.|||Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/188937:MA_RS20230 ^@ http://purl.uniprot.org/uniprot/Q8TJA9 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.|||Cell membrane|||Homodimer.|||Requires K(+) for maximal activity.|||Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane. http://togogenome.org/gene/188937:MA_RS05630 ^@ http://purl.uniprot.org/uniprot/Q8TRU0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/188937:MA_RS05695 ^@ http://purl.uniprot.org/uniprot/Q8TRS7 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Part of the 30S ribosomal subunit. Contacts protein S4.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/188937:MA_RS03915 ^@ http://purl.uniprot.org/uniprot/Q8TSP6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS12620 ^@ http://purl.uniprot.org/uniprot/Q8TN63 ^@ Function|||Similarity ^@ Belongs to the archaeal 6-HMPDK family.|||Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP). http://togogenome.org/gene/188937:MA_RS10695 ^@ http://purl.uniprot.org/uniprot/Q8TP62 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS07810 ^@ http://purl.uniprot.org/uniprot/Q8TQN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Membrane http://togogenome.org/gene/188937:MA_RS21460 ^@ http://purl.uniprot.org/uniprot/Q8TIN3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family. http://togogenome.org/gene/188937:MA_RS07480 ^@ http://purl.uniprot.org/uniprot/Q8TQV0 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. NudC subfamily. http://togogenome.org/gene/188937:MA_RS21265 ^@ http://purl.uniprot.org/uniprot/Q8TIR7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the transcriptional regulatory CopG/NikR family.|||Binds 1 nickel ion per subunit.|||Transcriptional regulator. http://togogenome.org/gene/188937:MA_RS00620 ^@ http://purl.uniprot.org/uniprot/Q8TUE8 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/188937:MA_RS21165 ^@ http://purl.uniprot.org/uniprot/Q8TIT6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/188937:MA_RS06230 ^@ http://purl.uniprot.org/uniprot/Q8TRH8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS05670 ^@ http://purl.uniprot.org/uniprot/Q8TRT2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/188937:MA_RS03930 ^@ http://purl.uniprot.org/uniprot/Q8TSP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S16 family.|||Membrane http://togogenome.org/gene/188937:MA_RS11455 ^@ http://purl.uniprot.org/uniprot/Q8TNS2 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/188937:MA_RS22700 ^@ http://purl.uniprot.org/uniprot/Q8TI14 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS05710 ^@ http://purl.uniprot.org/uniprot/Q8TRS4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/188937:MA_RS11120 ^@ http://purl.uniprot.org/uniprot/Q8TNY7 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/188937:MA_RS10480 ^@ http://purl.uniprot.org/uniprot/Q8TPA1 ^@ Subcellular Location Annotation ^@ Cell inner membrane http://togogenome.org/gene/188937:MA_RS05685 ^@ http://purl.uniprot.org/uniprot/Q8TRS9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/188937:MA_RS22165 ^@ http://purl.uniprot.org/uniprot/Q8TIB0 ^@ Similarity ^@ Belongs to the UPF0251 family. http://togogenome.org/gene/188937:MA_RS22685 ^@ http://purl.uniprot.org/uniprot/Q8TI17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BioY family.|||Cell membrane http://togogenome.org/gene/188937:MA_RS00695 ^@ http://purl.uniprot.org/uniprot/P58812 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/188937:MA_RS07700 ^@ http://purl.uniprot.org/uniprot/Q8TQQ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS08295 ^@ http://purl.uniprot.org/uniprot/Q8TQE8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS20545 ^@ http://purl.uniprot.org/uniprot/Q8TJ51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS21205 ^@ http://purl.uniprot.org/uniprot/Q8TIS8 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/188937:MA_RS08980 ^@ http://purl.uniprot.org/uniprot/Q8TQ23 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS04680 ^@ http://purl.uniprot.org/uniprot/Q8TSA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/188937:MA_RS23350 ^@ http://purl.uniprot.org/uniprot/Q8THP0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DapB family.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.|||Cytoplasm|||Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. http://togogenome.org/gene/188937:MA_RS01135 ^@ http://purl.uniprot.org/uniprot/Q8TU61 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/188937:MA_RS13930 ^@ http://purl.uniprot.org/uniprot/Q8TMI6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family.|||Binds 2 manganese ions per subunit.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/188937:MA_RS11860 ^@ http://purl.uniprot.org/uniprot/Q8TNJ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS03770 ^@ http://purl.uniprot.org/uniprot/Q8TSS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSL4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. http://togogenome.org/gene/188937:MA_RS09465 ^@ http://purl.uniprot.org/uniprot/Q8TPT7 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/188937:MA_RS00395 ^@ http://purl.uniprot.org/uniprot/P60459 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC61-beta family.|||Cell membrane|||Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer (By similarity).|||Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex (By similarity). http://togogenome.org/gene/188937:MA_RS04865 ^@ http://purl.uniprot.org/uniprot/Q8TS68 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS22305 ^@ http://purl.uniprot.org/uniprot/Q8TI84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. http://togogenome.org/gene/188937:MA_RS06830 ^@ http://purl.uniprot.org/uniprot/Q8TR65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS16210 ^@ http://purl.uniprot.org/uniprot/Q8TLD8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS11660 ^@ http://purl.uniprot.org/uniprot/Q8TNN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nurim family.|||Membrane http://togogenome.org/gene/188937:MA_RS22125 ^@ http://purl.uniprot.org/uniprot/Q8TIB8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HdrB family.|||Binds 1 [4Fe-4S] cluster.|||Cytoplasm|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Catalyzes the transfer of electrons from ferredoxin to CoM-S-S-CoB during methanogenesis from acetate. Electrons transfer from ferredoxin to CoM-S-S-CoB via HdrA2, HdrC2 and HdrB2. In addition, the complex can use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB-CoM heterodisulfide. This activity may take place during Fe(III)-dependent anaerobic methane oxidation.|||The ferredoxin/F(420)H(2)-dependent CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA2, HdrB2 and HdrC2. http://togogenome.org/gene/188937:MA_RS05625 ^@ http://purl.uniprot.org/uniprot/Q8TRU1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/188937:MA_RS10075 ^@ http://purl.uniprot.org/uniprot/Q8TPH8 ^@ Similarity ^@ Belongs to the CRISPR-associated Csm4 family. http://togogenome.org/gene/188937:MA_RS08775 ^@ http://purl.uniprot.org/uniprot/Q8TQ61 ^@ Similarity ^@ Belongs to the UPF0210 family. http://togogenome.org/gene/188937:MA_RS09820 ^@ http://purl.uniprot.org/uniprot/Q8TH29 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/188937:MA_RS05595 ^@ http://purl.uniprot.org/uniprot/Q8TRU7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e. http://togogenome.org/gene/188937:MA_RS23635 ^@ http://purl.uniprot.org/uniprot/Q8THI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/188937:MA_RS23550 ^@ http://purl.uniprot.org/uniprot/Q8THJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS03150 ^@ http://purl.uniprot.org/uniprot/Q8TT40 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/188937:MA_RS06310 ^@ http://purl.uniprot.org/uniprot/Q8TH41 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the NifH/BchL/ChlL family.|||Binds 1 [4Fe-4S] cluster per dimer.|||Homodimer.|||The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.|||The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.|||The reversible ADP-ribosylation of Arg-100 inactivates the nitrogenase reductase and regulates nitrogenase activity. http://togogenome.org/gene/188937:MA_RS17275 ^@ http://purl.uniprot.org/uniprot/P58859 ^@ Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer. http://togogenome.org/gene/188937:MA_RS04250 ^@ http://purl.uniprot.org/uniprot/Q8TSI1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/188937:MA_RS18520 ^@ http://purl.uniprot.org/uniprot/Q8TK70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic CoaD family.|||Cytoplasm|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/188937:MA_RS17650 ^@ http://purl.uniprot.org/uniprot/Q8TKM1 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/188937:MA_RS05745 ^@ http://purl.uniprot.org/uniprot/Q8TRR7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS07215 ^@ http://purl.uniprot.org/uniprot/P58834 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA-PH family.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS20115 ^@ http://purl.uniprot.org/uniprot/Q8TJD0 ^@ Similarity ^@ Belongs to the UPF0285 family. http://togogenome.org/gene/188937:MA_RS07275 ^@ http://purl.uniprot.org/uniprot/Q8TQY5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||S-layer http://togogenome.org/gene/188937:MA_RS11780 ^@ http://purl.uniprot.org/uniprot/Q8TNL5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS21920 ^@ http://purl.uniprot.org/uniprot/Q8TIF3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/188937:MA_RS18870 ^@ http://purl.uniprot.org/uniprot/Q8TK06 ^@ Function ^@ Protects DNA against thermal denaturation and modulates transcription. http://togogenome.org/gene/188937:MA_RS03755 ^@ http://purl.uniprot.org/uniprot/Q8TSS8 ^@ Biotechnology|||Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.|||Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.|||Cells have increased resistant to purine analogs 8-aza-2,6-diaminopurine (8-ADP) and 2-methylpurine (2MP). No change in growth rate in HS (minimal) broth.|||Cytoplasm|||Homodimer.|||Used for negative selection when transforming this organism. http://togogenome.org/gene/188937:MA_RS07730 ^@ http://purl.uniprot.org/uniprot/Q8TQQ1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. CofH family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.|||Consists of two subunits, CofG and CofH. http://togogenome.org/gene/188937:MA_RS20705 ^@ http://purl.uniprot.org/uniprot/Q8TJ20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GGGP/HepGP synthase family. Group II subfamily.|||Cytoplasm|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/188937:MA_RS20860 ^@ http://purl.uniprot.org/uniprot/Q8TIZ1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS06425 ^@ http://purl.uniprot.org/uniprot/Q8TRE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS06525 ^@ http://purl.uniprot.org/uniprot/Q8TRC2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/188937:MA_RS14380 ^@ http://purl.uniprot.org/uniprot/Q8TMB9 ^@ Similarity ^@ Belongs to the UPF0677 family. http://togogenome.org/gene/188937:MA_RS18390 ^@ http://purl.uniprot.org/uniprot/Q8TK95 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/188937:MA_RS04655 ^@ http://purl.uniprot.org/uniprot/Q8TSA4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/188937:MA_RS23815 ^@ http://purl.uniprot.org/uniprot/Q8THE9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS17655 ^@ http://purl.uniprot.org/uniprot/Q8TKM0 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/188937:MA_RS19700 ^@ http://purl.uniprot.org/uniprot/Q8TJK1 ^@ Activity Regulation|||Function|||Similarity ^@ Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.|||Catalyzes the transfer of a methyl group from AdoMet to arsenite, producing methylated arsenicals. Involved in the conversion of As(III) to a number of methylated products. Reduces the arsenic toxicity in the cell and may contribute to the global arsenic cycling.|||Highly dependent on the characteristics of the thiol cofactors used, with some of them (coenzyme M, homocysteine, and dithiothreitol) more efficient than GSH. http://togogenome.org/gene/188937:MA_RS05665 ^@ http://purl.uniprot.org/uniprot/Q8TRT3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/188937:MA_RS12640 ^@ http://purl.uniprot.org/uniprot/Q8TN59 ^@ Similarity ^@ Belongs to the ATPase alpha/beta chains family. http://togogenome.org/gene/188937:MA_RS03660 ^@ http://purl.uniprot.org/uniprot/Q8TSU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/188937:MA_RS23295 ^@ http://purl.uniprot.org/uniprot/Q8THQ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS04525 ^@ http://purl.uniprot.org/uniprot/Q8TSC9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS07010 ^@ http://purl.uniprot.org/uniprot/Q8TR33 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity). http://togogenome.org/gene/188937:MA_RS05915 ^@ http://purl.uniprot.org/uniprot/Q8TRN9 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/188937:MA_RS09665 ^@ http://purl.uniprot.org/uniprot/Q8TPQ4 ^@ Similarity ^@ Belongs to the HepT RNase toxin family. http://togogenome.org/gene/188937:MA_RS15010 ^@ http://purl.uniprot.org/uniprot/Q8TM11 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/188937:MA_RS11965 ^@ http://purl.uniprot.org/uniprot/Q8TNI1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/188937:MA_RS05615 ^@ http://purl.uniprot.org/uniprot/Q8TRU3 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/188937:MA_RS23530 ^@ http://purl.uniprot.org/uniprot/Q8THK3 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/188937:MA_RS05635 ^@ http://purl.uniprot.org/uniprot/Q8TRT9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/188937:MA_RS18055 ^@ http://purl.uniprot.org/uniprot/Q8TKF0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS06295 ^@ http://purl.uniprot.org/uniprot/Q8TRG9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NifD/NifK/NifE/NifN family.|||Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).|||This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation. http://togogenome.org/gene/188937:MA_RS04820 ^@ http://purl.uniprot.org/uniprot/Q8TS74 ^@ Function|||Similarity|||Subunit ^@ Acts probably as a methyl group carrier between MttB and either MtbA or MtaA.|||Belongs to the methylamine corrinoid protein family.|||Can form a complex with MttB. http://togogenome.org/gene/188937:MA_RS19720 ^@ http://purl.uniprot.org/uniprot/Q8TJJ7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/188937:MA_RS11995 ^@ http://purl.uniprot.org/uniprot/Q8TNH6 ^@ Caution|||Similarity ^@ Belongs to the peptidase S8 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/188937:MA_RS18810 ^@ http://purl.uniprot.org/uniprot/Q8TK18 ^@ Similarity ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family. http://togogenome.org/gene/188937:MA_RS22715 ^@ http://purl.uniprot.org/uniprot/Q8TI11 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS14250 ^@ http://purl.uniprot.org/uniprot/Q8TMD5 ^@ Function|||Similarity ^@ Belongs to the Thz kinase family.|||Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ). http://togogenome.org/gene/188937:MA_RS14770 ^@ http://purl.uniprot.org/uniprot/Q8TM51 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS09980 ^@ http://purl.uniprot.org/uniprot/Q8TPJ7 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 5 family. http://togogenome.org/gene/188937:MA_RS13770 ^@ http://purl.uniprot.org/uniprot/Q8TML2 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/188937:MA_RS21445 ^@ http://purl.uniprot.org/uniprot/Q8TIN6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/188937:MA_RS18225 ^@ http://purl.uniprot.org/uniprot/Q8TKC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/188937:MA_RS06565 ^@ http://purl.uniprot.org/uniprot/Q8TRB4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/188937:MA_RS12455 ^@ http://purl.uniprot.org/uniprot/Q8TN93 ^@ Function|||Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/188937:MA_RS04710 ^@ http://purl.uniprot.org/uniprot/Q8TS96 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRA-CH family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/188937:MA_RS06360 ^@ http://purl.uniprot.org/uniprot/Q8TRF7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Component of a hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. These reactions are part of the biosynthesis pathway of coenzyme B.|||Functional assignment as methanogen HACN has been made based on the presence of the YLRT motif involved in substrate specificity as discussed in PubMed:20170198.|||Heterotetramer of 2 HacA and 2 HacB proteins. Cannot form a complex with LeuC. http://togogenome.org/gene/188937:MA_RS15885 ^@ http://purl.uniprot.org/uniprot/Q8TLK3 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/188937:MA_RS24200 ^@ http://purl.uniprot.org/uniprot/Q8TH84 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase. http://togogenome.org/gene/188937:MA_RS22290 ^@ http://purl.uniprot.org/uniprot/Q8TI87 ^@ Similarity ^@ Belongs to the UPF0215 family. http://togogenome.org/gene/188937:MA_RS06300 ^@ http://purl.uniprot.org/uniprot/Q8TRG8 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/188937:MA_RS09305 ^@ http://purl.uniprot.org/uniprot/Q8TPW4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. http://togogenome.org/gene/188937:MA_RS17810 ^@ http://purl.uniprot.org/uniprot/Q8TKJ4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/188937:MA_RS16885 ^@ http://purl.uniprot.org/uniprot/Q8TL08 ^@ Similarity ^@ Belongs to the UPF0237 family. http://togogenome.org/gene/188937:MA_RS01805 ^@ http://purl.uniprot.org/uniprot/Q8TTT4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.|||Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. http://togogenome.org/gene/188937:MA_RS20985 ^@ http://purl.uniprot.org/uniprot/Q8TIW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). http://togogenome.org/gene/188937:MA_RS02560 ^@ http://purl.uniprot.org/uniprot/Q8TTE6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS08140 ^@ http://purl.uniprot.org/uniprot/Q8TQH7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/188937:MA_RS19250 ^@ http://purl.uniprot.org/uniprot/Q8TJT2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/188937:MA_RS01405 ^@ http://purl.uniprot.org/uniprot/Q8TU12 ^@ Subunit ^@ Homotetramer. http://togogenome.org/gene/188937:MA_RS05895 ^@ http://purl.uniprot.org/uniprot/Q8TRP3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS05925 ^@ http://purl.uniprot.org/uniprot/Q8TRN7 ^@ Function|||Similarity ^@ Belongs to the HypA/HybF family.|||Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. http://togogenome.org/gene/188937:MA_RS11820 ^@ http://purl.uniprot.org/uniprot/Q8TNK6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS22765 ^@ http://purl.uniprot.org/uniprot/Q8TI04 ^@ Similarity ^@ Belongs to the alkaline phosphatase family. http://togogenome.org/gene/188937:MA_RS22190 ^@ http://purl.uniprot.org/uniprot/Q8TIA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS20340 ^@ http://purl.uniprot.org/uniprot/Q8TJ91 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/188937:MA_RS19755 ^@ http://purl.uniprot.org/uniprot/Q8TJJ2 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/188937:MA_RS01420 ^@ http://purl.uniprot.org/uniprot/Q8TU09 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Monomer. http://togogenome.org/gene/188937:MA_RS17205 ^@ http://purl.uniprot.org/uniprot/Q8TKU6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 thiamine pyrophosphate per subunit.|||Involved in the biosynthesis of the coenzyme M (2-mercaptoethanesulfonic acid). Catalyzes the decarboxylation of sulfopyruvate to sulfoacetaldehyde. Is not able to decarboxylate the analogous compounds 2-oxoglutarate or 2-oxosuberate. http://togogenome.org/gene/188937:MA_RS20920 ^@ http://purl.uniprot.org/uniprot/Q8TIX9 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/188937:MA_RS22690 ^@ http://purl.uniprot.org/uniprot/Q8TI16 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.|||Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.|||Cell membrane|||Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component). http://togogenome.org/gene/188937:MA_RS01330 ^@ http://purl.uniprot.org/uniprot/Q8TU25 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/188937:MA_RS18805 ^@ http://purl.uniprot.org/uniprot/Q8TK19 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/188937:MA_RS17025 ^@ http://purl.uniprot.org/uniprot/Q8TKY0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS18200 ^@ http://purl.uniprot.org/uniprot/Q8TKC6 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/188937:MA_RS03140 ^@ http://purl.uniprot.org/uniprot/Q8TT41 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/188937:MA_RS06620 ^@ http://purl.uniprot.org/uniprot/Q8TRA5 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.|||Cytoplasm|||SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. http://togogenome.org/gene/188937:MA_RS10230 ^@ http://purl.uniprot.org/uniprot/Q8TPF0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/188937:MA_RS06920 ^@ http://purl.uniprot.org/uniprot/Q8TR50 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/188937:MA_RS20760 ^@ http://purl.uniprot.org/uniprot/Q8TJ11 ^@ Similarity ^@ Belongs to the radical SAM superfamily. KamA family. http://togogenome.org/gene/188937:MA_RS05270 ^@ http://purl.uniprot.org/uniprot/Q8TS00 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm|||Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.|||Heterodimer of two subunits, one of which binds GTP. http://togogenome.org/gene/188937:MA_RS08000 ^@ http://purl.uniprot.org/uniprot/Q8TQK3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS17160 ^@ http://purl.uniprot.org/uniprot/Q8TKV5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.|||Belongs to the peptidase S16 family. Archaeal LonB subfamily.|||Cell membrane|||Homohexamer. Organized in a ring with a central cavity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/188937:MA_RS19450 ^@ http://purl.uniprot.org/uniprot/Q8TJP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mer family.|||Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS24470 ^@ http://purl.uniprot.org/uniprot/Q8TQ53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the kinesin light chain family.|||cytoskeleton http://togogenome.org/gene/188937:MA_RS15675 ^@ http://purl.uniprot.org/uniprot/Q8TLP5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer. http://togogenome.org/gene/188937:MA_RS06815 ^@ http://purl.uniprot.org/uniprot/Q8TR67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/188937:MA_RS03125 ^@ http://purl.uniprot.org/uniprot/Q8TT44 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/188937:MA_RS16015 ^@ http://purl.uniprot.org/uniprot/Q8TLH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Archaeal flagellum|||Belongs to the archaeal flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella. http://togogenome.org/gene/188937:MA_RS00970 ^@ http://purl.uniprot.org/uniprot/Q8TU94 ^@ Function|||Similarity ^@ Belongs to the TBP family.|||General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. http://togogenome.org/gene/188937:MA_RS12915 ^@ http://purl.uniprot.org/uniprot/Q8TN09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS21095 ^@ http://purl.uniprot.org/uniprot/Q8TIV0 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. UPF0219 family. http://togogenome.org/gene/188937:MA_RS07550 ^@ http://purl.uniprot.org/uniprot/Q8TGX6 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. http://togogenome.org/gene/188937:MA_RS10435 ^@ http://purl.uniprot.org/uniprot/Q8TPA9 ^@ Similarity ^@ Belongs to the TlyA family. http://togogenome.org/gene/188937:MA_RS15825 ^@ http://purl.uniprot.org/uniprot/Q8TLL3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/188937:MA_RS00775 ^@ http://purl.uniprot.org/uniprot/P58869 ^@ Function|||Similarity ^@ Belongs to the uroporphyrinogen decarboxylase family. MtbA/MtaA subfamily.|||Methyltransferase involved in methanogenesis from methylamines methanol pathway. Catalyzes the transfer of the methyl group from the methylated corrinoid protein MtmC (MtmC1 or MtmC2) to coenzyme M, forming the substrate for coenzyme-B sulfoethylthiotransferase (By similarity). http://togogenome.org/gene/188937:MA_RS14560 ^@ http://purl.uniprot.org/uniprot/Q8TM85 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Arsenite methyltransferase family. http://togogenome.org/gene/188937:MA_RS22855 ^@ http://purl.uniprot.org/uniprot/Q8THY8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS08990 ^@ http://purl.uniprot.org/uniprot/Q8TQ21 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS10665 ^@ http://purl.uniprot.org/uniprot/Q8TP68 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/188937:MA_RS22925 ^@ http://purl.uniprot.org/uniprot/Q8THX4 ^@ Similarity ^@ Belongs to the methylamine corrinoid protein family. http://togogenome.org/gene/188937:MA_RS19670 ^@ http://purl.uniprot.org/uniprot/Q8TJK7 ^@ Similarity ^@ Belongs to the glucose-1-phosphate thymidylyltransferase family. http://togogenome.org/gene/188937:MA_RS09240 ^@ http://purl.uniprot.org/uniprot/Q8TPX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. http://togogenome.org/gene/188937:MA_RS12255 ^@ http://purl.uniprot.org/uniprot/Q8TNC6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS03410 ^@ http://purl.uniprot.org/uniprot/Q8TSZ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase small subunit family.|||Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL). http://togogenome.org/gene/188937:MA_RS17355 ^@ http://purl.uniprot.org/uniprot/Q8TKS3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/188937:MA_RS12655 ^@ http://purl.uniprot.org/uniprot/Q8TN56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Membrane http://togogenome.org/gene/188937:MA_RS09040 ^@ http://purl.uniprot.org/uniprot/Q8TQ11 ^@ Function ^@ Probably involved in the biogenesis of the ribosome. http://togogenome.org/gene/188937:MA_RS24140 ^@ http://purl.uniprot.org/uniprot/Q8TH95 ^@ Similarity ^@ Belongs to the bacterial reverse transcriptase family. http://togogenome.org/gene/188937:MA_RS23780 ^@ http://purl.uniprot.org/uniprot/Q8THF6 ^@ Cofactor|||Disruption Phenotype|||Function|||PTM|||Subcellular Location Annotation ^@ Autophosphorylates: autophosphorylation is dependent on the redox state of heme cofactor and is promoted upon reduction.|||Cells constitutively synthesize MtsF.|||Cytoplasm|||Heme-binding is redox-active and coordinates various ligands such as imidazole, dimethyl sulfide, and carbon monoxide depending on the redox state. The redox state of the heme cofactor influences on autophosphorylation activity: while reduced protein does not autophosphorylate, oxidized protein promotes autophosphorylation signal.|||Heme-binding sensor kinase component part of a two-component regulatory system involved in methyl sulfide metabolism. Does not act as a phytochrome-like photoreceptor. http://togogenome.org/gene/188937:MA_RS23850 ^@ http://purl.uniprot.org/uniprot/Q8THE3 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/188937:MA_RS18545 ^@ http://purl.uniprot.org/uniprot/Q8TK65 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). http://togogenome.org/gene/188937:MA_RS17915 ^@ http://purl.uniprot.org/uniprot/Q8TH29 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/188937:MA_RS22935 ^@ http://purl.uniprot.org/uniprot/Q8THX2 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/188937:MA_RS23700 ^@ http://purl.uniprot.org/uniprot/Q8THH1 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyl-coenzyme M reductase alpha subunit family.|||Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid (By similarity). Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state (By similarity).|||Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.|||Cytoplasm|||Is methylated on C5 of Arg-285 by the methyltransferase MA_4551. This post-translational methylation, despite being not essential in vivo, plays a role for the stability and structural integrity of MCR.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers. http://togogenome.org/gene/188937:MA_RS16725 ^@ http://purl.uniprot.org/uniprot/Q8TL39 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. Hel308 subfamily.|||DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.|||Monomer. http://togogenome.org/gene/188937:MA_RS15970 ^@ http://purl.uniprot.org/uniprot/Q8TLI4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/188937:MA_RS22850 ^@ http://purl.uniprot.org/uniprot/Q8THY9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS00050 ^@ http://purl.uniprot.org/uniprot/Q8TUQ4 ^@ Function|||Similarity ^@ Belongs to the CheD family.|||Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis. http://togogenome.org/gene/188937:MA_RS02720 ^@ http://purl.uniprot.org/uniprot/Q8TTB6 ^@ Function|||Similarity ^@ Belongs to the CbiD family.|||Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. http://togogenome.org/gene/188937:MA_RS14100 ^@ http://purl.uniprot.org/uniprot/Q8TMG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LPG synthase family.|||Membrane http://togogenome.org/gene/188937:MA_RS10930 ^@ http://purl.uniprot.org/uniprot/Q8TP21 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/188937:MA_RS18120 ^@ http://purl.uniprot.org/uniprot/Q8TKD8 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/188937:MA_RS22695 ^@ http://purl.uniprot.org/uniprot/Q8TI15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). http://togogenome.org/gene/188937:MA_RS03035 ^@ http://purl.uniprot.org/uniprot/Q8TT59 ^@ Similarity|||Subunit ^@ Belongs to the ALAD family.|||Homooctamer. http://togogenome.org/gene/188937:MA_RS21710 ^@ http://purl.uniprot.org/uniprot/Q8TII8 ^@ Similarity ^@ Belongs to the carbamoyltransferase HypF family. http://togogenome.org/gene/188937:MA_RS20855 ^@ http://purl.uniprot.org/uniprot/Q8TIZ2 ^@ Similarity ^@ Belongs to the UPF0288 family. http://togogenome.org/gene/188937:MA_RS13375 ^@ http://purl.uniprot.org/uniprot/Q8TMT1 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent DNA ligase family.|||DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. http://togogenome.org/gene/188937:MA_RS21685 ^@ http://purl.uniprot.org/uniprot/Q8TIJ3 ^@ Function|||Similarity ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/188937:MA_RS23960 ^@ http://purl.uniprot.org/uniprot/Q8THC6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.|||Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.|||Homodecamer. http://togogenome.org/gene/188937:MA_RS21380 ^@ http://purl.uniprot.org/uniprot/Q8TIP4 ^@ Cofactor|||Similarity ^@ Belongs to the UPF0292 family.|||Binds two Mg(2+) per subunit. http://togogenome.org/gene/188937:MA_RS19200 ^@ http://purl.uniprot.org/uniprot/Q8TJU2 ^@ Similarity ^@ Belongs to the UPF0179 family. http://togogenome.org/gene/188937:MA_RS21045 ^@ http://purl.uniprot.org/uniprot/Q8TIV9 ^@ Similarity ^@ Belongs to the UPF0228 family. http://togogenome.org/gene/188937:MA_RS18510 ^@ http://purl.uniprot.org/uniprot/Q8TK72 ^@ Function|||Similarity ^@ Belongs to the archaeal SPP-like hydrolase family.|||Catalyzes the dephosphorylation of 2-phosphoglycolate. http://togogenome.org/gene/188937:MA_RS06685 ^@ http://purl.uniprot.org/uniprot/Q8TR92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.|||Cytoplasm|||Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. http://togogenome.org/gene/188937:MA_RS20930 ^@ http://purl.uniprot.org/uniprot/Q8TIX7 ^@ Similarity ^@ Belongs to the PurH family. http://togogenome.org/gene/188937:MA_RS22030 ^@ http://purl.uniprot.org/uniprot/Q8TID5 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/188937:MA_RS05330 ^@ http://purl.uniprot.org/uniprot/Q8TRZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS11015 ^@ http://purl.uniprot.org/uniprot/Q8TP05 ^@ Similarity ^@ Belongs to the HsdR family. http://togogenome.org/gene/188937:MA_RS09230 ^@ http://purl.uniprot.org/uniprot/Q8TGX5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp42 subfamily.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. http://togogenome.org/gene/188937:MA_RS12855 ^@ http://purl.uniprot.org/uniprot/Q8TN20 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS13370 ^@ http://purl.uniprot.org/uniprot/Q8TMT2 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/188937:MA_RS19530 ^@ http://purl.uniprot.org/uniprot/Q8TJN2 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/188937:MA_RS07465 ^@ http://purl.uniprot.org/uniprot/Q8TQV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/188937:MA_RS17565 ^@ http://purl.uniprot.org/uniprot/Q8TKN5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS16955 ^@ http://purl.uniprot.org/uniprot/Q8TKZ3 ^@ Function|||Similarity ^@ Belongs to the CobB/CobQ family. CobQ subfamily.|||Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. http://togogenome.org/gene/188937:MA_RS22710 ^@ http://purl.uniprot.org/uniprot/Q8TI12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS06785 ^@ http://purl.uniprot.org/uniprot/Q8TR73 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the Ni-containing carbon monoxide dehydrogenase family.|||Binds 2 [Ni-4Fe-5S] clusters per homodimer.|||Binds 3 [4Fe-4S] clusters per homodimer.|||CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).|||Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer.|||Homodimer.|||This protein lacks the conserved Cys in positions 52 and 300; they are replaced by an Arg and a Glu, respectively. It is therefore possible that the C- and D-clusters are either altered or missing in this protein. http://togogenome.org/gene/188937:MA_RS04965 ^@ http://purl.uniprot.org/uniprot/Q8TS50 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NadC/ModD family.|||Hexamer formed by 3 homodimers.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/188937:MA_RS08240 ^@ http://purl.uniprot.org/uniprot/Q8TQF8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6A family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/188937:MA_RS23585 ^@ http://purl.uniprot.org/uniprot/Q8THJ2 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/188937:MA_RS07485 ^@ http://purl.uniprot.org/uniprot/Q8TQU9 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/188937:MA_RS16680 ^@ http://purl.uniprot.org/uniprot/Q8TL50 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/188937:MA_RS08220 ^@ http://purl.uniprot.org/uniprot/Q8TQG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NASP family.|||Nucleus http://togogenome.org/gene/188937:MA_RS03180 ^@ http://purl.uniprot.org/uniprot/Q8TT34 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.|||Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.|||Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/188937:MA_RS17445 ^@ http://purl.uniprot.org/uniprot/Q8TKQ6 ^@ Function|||Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family.|||Catalyzes the condensation of alpha-ketoglutarate and acetyl-CoA to form (R)-homocitrate. Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)-homo(2)citrate, and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)-homo(3)citrate. These reactions are part of the biosynthesis pathway of coenzyme B and biotin. http://togogenome.org/gene/188937:MA_RS02365 ^@ http://purl.uniprot.org/uniprot/Q8TTI1 ^@ Similarity ^@ Belongs to the glycosyltransferase 28 family. http://togogenome.org/gene/188937:MA_RS07805 ^@ http://purl.uniprot.org/uniprot/Q8TQN6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS20800 ^@ http://purl.uniprot.org/uniprot/Q8TJ03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Cytoplasm|||Functions by promoting the formation of the first peptide bond. http://togogenome.org/gene/188937:MA_RS24085 ^@ http://purl.uniprot.org/uniprot/Q8THA5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family.|||Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).|||Homodimer. http://togogenome.org/gene/188937:MA_RS03605 ^@ http://purl.uniprot.org/uniprot/Q8TSV7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HdrD family.|||Binds 2 [4Fe-4S] clusters per subunit.|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).|||The dihydromethanophenazine:CoB--CoM heterodisulfide reductase is composed of two subunits; HdrD and HdrE. http://togogenome.org/gene/188937:MA_RS18610 ^@ http://purl.uniprot.org/uniprot/Q8TK55 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Some bacteria possess a monofunctional ArgJ, i.e. capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/188937:MA_RS23595 ^@ http://purl.uniprot.org/uniprot/Q8THJ0 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/188937:MA_RS01820 ^@ http://purl.uniprot.org/uniprot/Q8TTT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/188937:MA_RS06475 ^@ http://purl.uniprot.org/uniprot/Q8TRD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS06635 ^@ http://purl.uniprot.org/uniprot/Q8TRA2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal phosphopantothenate synthetase family.|||Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.|||Homodimer. http://togogenome.org/gene/188937:MA_RS07670 ^@ http://purl.uniprot.org/uniprot/Q8TQR2 ^@ Function|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family. http://togogenome.org/gene/188937:MA_RS06435 ^@ http://purl.uniprot.org/uniprot/Q8TRE2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS16730 ^@ http://purl.uniprot.org/uniprot/Q8TL38 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS06555 ^@ http://purl.uniprot.org/uniprot/Q8TRB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Cytoplasm|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/188937:MA_RS04635 ^@ http://purl.uniprot.org/uniprot/Q8TSA8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.|||Cell membrane|||Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS). http://togogenome.org/gene/188937:MA_RS17290 ^@ http://purl.uniprot.org/uniprot/Q8TKT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm|||Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. http://togogenome.org/gene/188937:MA_RS18825 ^@ http://purl.uniprot.org/uniprot/Q8TK15 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/188937:MA_RS14060 ^@ http://purl.uniprot.org/uniprot/Q8TMG9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PEPCase type 2 family.|||Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.|||Homotetramer. http://togogenome.org/gene/188937:MA_RS06485 ^@ http://purl.uniprot.org/uniprot/Q8TRD1 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 5 family. http://togogenome.org/gene/188937:MA_RS19135 ^@ http://purl.uniprot.org/uniprot/Q8TJV6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/188937:MA_RS10570 ^@ http://purl.uniprot.org/uniprot/Q8TP84 ^@ Similarity ^@ Belongs to the NifH/BchL/ChlL family. http://togogenome.org/gene/188937:MA_RS01800 ^@ http://purl.uniprot.org/uniprot/Q8TTT5 ^@ Similarity ^@ Belongs to the NOP5/NOP56 family. http://togogenome.org/gene/188937:MA_RS00825 ^@ http://purl.uniprot.org/uniprot/Q8TUB8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS01165 ^@ http://purl.uniprot.org/uniprot/Q8TU57 ^@ Function|||Similarity ^@ Belongs to the AdoMet synthase 2 family.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/188937:MA_RS08435 ^@ http://purl.uniprot.org/uniprot/Q8TQC4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS13250 ^@ http://purl.uniprot.org/uniprot/Q8TMV3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS20370 ^@ http://purl.uniprot.org/uniprot/Q8TJ85 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS07910 ^@ http://purl.uniprot.org/uniprot/Q8TQL7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL24 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14. http://togogenome.org/gene/188937:MA_RS23710 ^@ http://purl.uniprot.org/uniprot/Q8THG9 ^@ Subunit ^@ MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known. http://togogenome.org/gene/188937:MA_RS15835 ^@ http://purl.uniprot.org/uniprot/Q8TLL1 ^@ Similarity ^@ In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/188937:MA_RS04200 ^@ http://purl.uniprot.org/uniprot/Q8TSJ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS23165 ^@ http://purl.uniprot.org/uniprot/Q8THS9 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/188937:MA_RS13175 ^@ http://purl.uniprot.org/uniprot/Q8TMW6 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/188937:MA_RS20160 ^@ http://purl.uniprot.org/uniprot/Q8TH44 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 [4Fe-4S] cluster.|||Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).|||Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. http://togogenome.org/gene/188937:MA_RS04745 ^@ http://purl.uniprot.org/uniprot/Q8TS89 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS21825 ^@ http://purl.uniprot.org/uniprot/Q8TH39 ^@ Similarity ^@ Belongs to the bacterial reverse transcriptase family. http://togogenome.org/gene/188937:MA_RS10860 ^@ http://purl.uniprot.org/uniprot/Q8TP33 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/188937:MA_RS22300 ^@ http://purl.uniprot.org/uniprot/Q8TI85 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/188937:MA_RS01505 ^@ http://purl.uniprot.org/uniprot/Q8TTZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ModE family.|||Membrane http://togogenome.org/gene/188937:MA_RS14120 ^@ http://purl.uniprot.org/uniprot/Q8TMG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.|||Carboxyl methyltransferase with activity toward prenyl lipids. In vitro, displays activity toward N-acetyl-S-farnesyl-L-cysteine (AFC) and S-farnesylthioacetic acid (FTA), an analog of AFC.|||Cell membrane http://togogenome.org/gene/188937:MA_RS09475 ^@ http://purl.uniprot.org/uniprot/Q8TPT5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal FAD synthase family.|||Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.|||Homodimer. http://togogenome.org/gene/188937:MA_RS16410 ^@ http://purl.uniprot.org/uniprot/Q8TLA2 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/188937:MA_RS17745 ^@ http://purl.uniprot.org/uniprot/Q8TKK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/188937:MA_RS08020 ^@ http://purl.uniprot.org/uniprot/Q8TQJ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS06825 ^@ http://purl.uniprot.org/uniprot/Q8TR66 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the asparaginase 1 family. GatD subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/188937:MA_RS03805 ^@ http://purl.uniprot.org/uniprot/Q8TSR8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/188937:MA_RS07150 ^@ http://purl.uniprot.org/uniprot/Q8TR06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS20535 ^@ http://purl.uniprot.org/uniprot/Q8TJ54 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.|||Cell membrane|||Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function. http://togogenome.org/gene/188937:MA_RS01770 ^@ http://purl.uniprot.org/uniprot/Q8TTU1 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/188937:MA_RS04345 ^@ http://purl.uniprot.org/uniprot/Q8TSG2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the FwdB family.|||Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.|||This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG. http://togogenome.org/gene/188937:MA_RS08480 ^@ http://purl.uniprot.org/uniprot/Q8TQB5 ^@ Similarity ^@ Belongs to the NifH/BchL/ChlL family. http://togogenome.org/gene/188937:MA_RS23720 ^@ http://purl.uniprot.org/uniprot/Q8THG7 ^@ Similarity|||Subunit ^@ Belongs to the methyl-coenzyme M reductase beta subunit family.|||Hexamer of two alpha, two beta, and two gamma chains.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers. http://togogenome.org/gene/188937:MA_RS06515 ^@ http://purl.uniprot.org/uniprot/Q8TRC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/188937:MA_RS01250 ^@ http://purl.uniprot.org/uniprot/Q8TU41 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS12850 ^@ http://purl.uniprot.org/uniprot/Q8TN21 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS11830 ^@ http://purl.uniprot.org/uniprot/Q8TNK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS07080 ^@ http://purl.uniprot.org/uniprot/Q8TR21 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/188937:MA_RS17795 ^@ http://purl.uniprot.org/uniprot/Q8TKJ7 ^@ Function|||Similarity ^@ Belongs to the PEP-utilizing enzyme family.|||Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. http://togogenome.org/gene/188937:MA_RS02840 ^@ http://purl.uniprot.org/uniprot/Q8TT96 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/188937:MA_RS22320 ^@ http://purl.uniprot.org/uniprot/Q8TI81 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. Probably involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA. http://togogenome.org/gene/188937:MA_RS00810 ^@ http://purl.uniprot.org/uniprot/Q8TUC1 ^@ Disruption Phenotype|||Function|||Similarity ^@ Belongs to the PylD family.|||Cells lacking this gene are unable to translate UAG as pyrrolysine, and do not produce pyrrolysine.|||Likely catalyzes the NAD(P)-dependent oxidative deamination of (3R)-3-methyl-D-ornithyl-N6-L-lysine, resulting in the formation of pyrrolysine after spontaneous dehydration and cyclization of the intermediate. Is required for the biosynthesis of pyrrolysine. http://togogenome.org/gene/188937:MA_RS12945 ^@ http://purl.uniprot.org/uniprot/Q8TN04 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS15185 ^@ http://purl.uniprot.org/uniprot/Q8TLX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/188937:MA_RS15025 ^@ http://purl.uniprot.org/uniprot/Q8TM08 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the GatB/GatE family. GatE subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/188937:MA_RS05605 ^@ http://purl.uniprot.org/uniprot/Q8TRU5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29. http://togogenome.org/gene/188937:MA_RS14245 ^@ http://purl.uniprot.org/uniprot/Q8TMD6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the thiamine-phosphate synthase family.|||Binds 1 Mg(2+) ion per subunit.|||Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). http://togogenome.org/gene/188937:MA_RS02300 ^@ http://purl.uniprot.org/uniprot/Q8TTJ2 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.|||Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.|||Homodecamer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/188937:MA_RS08035 ^@ http://purl.uniprot.org/uniprot/Q8TQJ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS12470 ^@ http://purl.uniprot.org/uniprot/Q8TN90 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/188937:MA_RS00580 ^@ http://purl.uniprot.org/uniprot/Q8TUF7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. http://togogenome.org/gene/188937:MA_RS10800 ^@ http://purl.uniprot.org/uniprot/Q8TH54 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/188937:MA_RS18090 ^@ http://purl.uniprot.org/uniprot/Q8TKE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS17200 ^@ http://purl.uniprot.org/uniprot/Q8TKU7 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Belongs to the threonine synthase family. Cysteate synthase subfamily.|||Homotrimer.|||Is inhibited by AP3 (DL-2-amino-3-phosphonopropionate) and, to a lesser extent, by L-aspartate or AP4 (DL-2-amino-4-phosphonobutyrate). Is also inhibited by EDTA in vitro.|||Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate. Does not display threonine synthase activity like the paralog protein ThrC. http://togogenome.org/gene/188937:MA_RS06235 ^@ http://purl.uniprot.org/uniprot/Q8TRH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/188937:MA_RS04540 ^@ http://purl.uniprot.org/uniprot/Q8TSC6 ^@ Similarity ^@ Belongs to the Mg-chelatase subunit H family. http://togogenome.org/gene/188937:MA_RS20935 ^@ http://purl.uniprot.org/uniprot/Q8TIX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS01045 ^@ http://purl.uniprot.org/uniprot/Q8TU79 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS19750 ^@ http://purl.uniprot.org/uniprot/Q8TJJ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/188937:MA_RS02535 ^@ http://purl.uniprot.org/uniprot/Q8TTF1 ^@ Similarity ^@ Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family. http://togogenome.org/gene/188937:MA_RS05265 ^@ http://purl.uniprot.org/uniprot/Q8TS01 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS00440 ^@ http://purl.uniprot.org/uniprot/Q8TUI1 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/188937:MA_RS14830 ^@ http://purl.uniprot.org/uniprot/Q8TM42 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/188937:MA_RS10070 ^@ http://purl.uniprot.org/uniprot/Q8TPH9 ^@ Similarity ^@ Belongs to the CRISPR-associated Csm3 family. http://togogenome.org/gene/188937:MA_RS20710 ^@ http://purl.uniprot.org/uniprot/Q8TJ19 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL40 family. http://togogenome.org/gene/188937:MA_RS07290 ^@ http://purl.uniprot.org/uniprot/Q8TQY2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS00415 ^@ http://purl.uniprot.org/uniprot/Q8TUI7 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.|||Has ATPase and non-specific DNA-binding activities. http://togogenome.org/gene/188937:MA_RS01105 ^@ http://purl.uniprot.org/uniprot/Q8TU67 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. http://togogenome.org/gene/188937:MA_RS24195 ^@ http://purl.uniprot.org/uniprot/Q8TH85 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS09715 ^@ http://purl.uniprot.org/uniprot/Q8TPP4 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity.|||Membrane http://togogenome.org/gene/188937:MA_RS06780 ^@ http://purl.uniprot.org/uniprot/Q8TR74 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/188937:MA_RS00180 ^@ http://purl.uniprot.org/uniprot/Q8TUN1 ^@ Function ^@ Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/188937:MA_RS10650 ^@ http://purl.uniprot.org/uniprot/P58850 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DtdA deacylase family.|||Binds 2 Zn(2+) ions per subunit.|||D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.|||Monomer. http://togogenome.org/gene/188937:MA_RS01440 ^@ http://purl.uniprot.org/uniprot/Q8TU04 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrF family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/188937:MA_RS20795 ^@ http://purl.uniprot.org/uniprot/Q8TJ04 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/188937:MA_RS01550 ^@ http://purl.uniprot.org/uniprot/Q8TTY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP19 family.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/188937:MA_RS07765 ^@ http://purl.uniprot.org/uniprot/Q8TQP4 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/188937:MA_RS12730 ^@ http://purl.uniprot.org/uniprot/Q8TN43 ^@ Similarity ^@ Belongs to the CutA family. http://togogenome.org/gene/188937:MA_RS22260 ^@ http://purl.uniprot.org/uniprot/Q8TI93 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.|||Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. http://togogenome.org/gene/188937:MA_RS01590 ^@ http://purl.uniprot.org/uniprot/Q8TTX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/188937:MA_RS19040 ^@ http://purl.uniprot.org/uniprot/Q8TJX5 ^@ Similarity ^@ Belongs to the amidinotransferase family. http://togogenome.org/gene/188937:MA_RS02760 ^@ http://purl.uniprot.org/uniprot/Q8TTB0 ^@ Function|||Similarity ^@ Acts as a methyl group carrier between MtbB and MtbA.|||Belongs to the methylamine corrinoid protein family. http://togogenome.org/gene/188937:MA_RS05055 ^@ http://purl.uniprot.org/uniprot/Q8TS35 ^@ Similarity ^@ Belongs to the Fur family. http://togogenome.org/gene/188937:MA_RS06320 ^@ http://purl.uniprot.org/uniprot/Q8TRG5 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/188937:MA_RS19590 ^@ http://purl.uniprot.org/uniprot/Q8TH29 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/188937:MA_RS20330 ^@ http://purl.uniprot.org/uniprot/Q8TJ93 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the NifH/BchL/ChlL family.|||Binds 1 [4Fe-4S] cluster per dimer.|||Homodimer.|||The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.|||The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.|||The reversible ADP-ribosylation of Arg-98 inactivates the nitrogenase reductase and regulates nitrogenase activity. http://togogenome.org/gene/188937:MA_RS15525 ^@ http://purl.uniprot.org/uniprot/Q8TLR9 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/188937:MA_RS21955 ^@ http://purl.uniprot.org/uniprot/Q8TIE6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS07705 ^@ http://purl.uniprot.org/uniprot/Q8TQQ6 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.|||Binds 1 FAD per subunit.|||Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains (By similarity) (PubMed:24214941). Requires the adjacently encoded ferredoxin MA_1485 as the electron donor (PubMed:24214941).|||Reduction reaction proceeds via syn addition of hydrogen for double bonds. http://togogenome.org/gene/188937:MA_RS19305 ^@ http://purl.uniprot.org/uniprot/Q8TJS2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Fe(2+) ion per subunit.|||Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.|||Cytoplasm|||In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.|||In the N-terminal section; belongs to the KAE1 / TsaD family.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. http://togogenome.org/gene/188937:MA_RS05310 ^@ http://purl.uniprot.org/uniprot/Q8TRZ4 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the Ni-containing carbon monoxide dehydrogenase family.|||Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.|||Binds 7 [4Fe-4S] clusters per heterotetramer.|||Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.|||Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).|||Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. http://togogenome.org/gene/188937:MA_RS19745 ^@ http://purl.uniprot.org/uniprot/Q8TJJ4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. http://togogenome.org/gene/188937:MA_RS15055 ^@ http://purl.uniprot.org/uniprot/Q8TM02 ^@ Cofactor|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HdrA family.|||Binds 1 [2Fe-2S] cluster.|||Binds 4 [4Fe-4S] cluster.|||Cytoplasm|||Induced by growth on methanol or acetate.|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Catalyzes the transfer of electrons from ferredoxin to CoM-S-S-CoB during methanogenesis from acetate. Electrons transfer from ferredoxin to CoM-S-S-CoB via HdrA2, HdrC2 and HdrB2. In addition, the complex can use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB-CoM heterodisulfide. This activity may take place during Fe(III)-dependent anaerobic methane oxidation.|||The ferredoxin/F(420)H(2)-dependent CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA2, HdrB2 and HdrC2. http://togogenome.org/gene/188937:MA_RS06530 ^@ http://purl.uniprot.org/uniprot/Q8TRC1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Part of the 30S ribosomal subunit.|||With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. http://togogenome.org/gene/188937:MA_RS05655 ^@ http://purl.uniprot.org/uniprot/Q8TRT5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/188937:MA_RS04890 ^@ http://purl.uniprot.org/uniprot/Q8TS64 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobD/CbiB family.|||Cell membrane|||Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/188937:MA_RS04400 ^@ http://purl.uniprot.org/uniprot/Q8TSF4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS01960 ^@ http://purl.uniprot.org/uniprot/Q8TTQ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS00715 ^@ http://purl.uniprot.org/uniprot/Q8TUD2 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/188937:MA_RS00690 ^@ http://purl.uniprot.org/uniprot/Q8TUD6 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/188937:MA_RS17505 ^@ http://purl.uniprot.org/uniprot/Q8TKP6 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/188937:MA_RS21950 ^@ http://purl.uniprot.org/uniprot/Q8TIE7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS18585 ^@ http://purl.uniprot.org/uniprot/Q8TGX2 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A single active site specifically recognizes both ATP and CTP and is responsible for their addition.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.|||Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.|||Homodimer. http://togogenome.org/gene/188937:MA_RS08370 ^@ http://purl.uniprot.org/uniprot/Q8TQD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS12020 ^@ http://purl.uniprot.org/uniprot/Q8TNH2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS15925 ^@ http://purl.uniprot.org/uniprot/Q8TLJ3 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/188937:MA_RS09260 ^@ http://purl.uniprot.org/uniprot/Q8TPX2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/188937:MA_RS00015 ^@ http://purl.uniprot.org/uniprot/Q8TH29 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/188937:MA_RS04900 ^@ http://purl.uniprot.org/uniprot/Q8TS62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS21560 ^@ http://purl.uniprot.org/uniprot/Q8TH29 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/188937:MA_RS03490 ^@ http://purl.uniprot.org/uniprot/Q8TSX9 ^@ Cofactor|||Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.|||Binds 5 [4Fe-4S] clusters.|||Cell membrane|||Deletion of the rnf operon abolishes growth on acetate and ferredoxin:heterodisulfide oxidoreductase-coupled Na(+) transport.|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Catalyzes Na(+) transport, most probably coupled to electron transfer from reduced ferredoxin to methanophenazine and heterodisulfide reductase. Involved in heterodisulfide reduction during methanogenesis from acetate.|||The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/188937:MA_RS16345 ^@ http://purl.uniprot.org/uniprot/Q8TLB2 ^@ Cofactor|||Disruption Phenotype|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HdrB family.|||Binds 1 [4Fe-4S] cluster.|||Cytoplasm|||Induced on trimethylamine or methanol, but not on acetate as the sole energy source.|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Probably involved in methylotrophic methanogenesis but not in aceticlastic methanogenesis.|||The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA1, HdrB1 and HdrC1.|||Triple hdrA1C1B1 deletion decreases methane production from methanol, but does not affect methanogenesis from acetate. Deletion results in up-regulation of CoB-SH and CoM-SH synthesis and transport, and methylsulfide methyltransferases. http://togogenome.org/gene/188937:MA_RS09440 ^@ http://purl.uniprot.org/uniprot/Q8TPU1 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/188937:MA_RS09960 ^@ http://purl.uniprot.org/uniprot/Q8TPK1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS09370 ^@ http://purl.uniprot.org/uniprot/Q8TPV2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer. http://togogenome.org/gene/188937:MA_RS06185 ^@ http://purl.uniprot.org/uniprot/P58796 ^@ Cofactor|||Similarity ^@ Belongs to the WrbA family.|||Binds 1 FMN per monomer. http://togogenome.org/gene/188937:MA_RS14790 ^@ http://purl.uniprot.org/uniprot/Q8TH29 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/188937:MA_RS11130 ^@ http://purl.uniprot.org/uniprot/Q8TNY4 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/188937:MA_RS07735 ^@ http://purl.uniprot.org/uniprot/Q8TQQ0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. CofH family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.|||Consists of two subunits, CofG and CofH. http://togogenome.org/gene/188937:MA_RS21425 ^@ http://purl.uniprot.org/uniprot/Q8TIN9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS10325 ^@ http://purl.uniprot.org/uniprot/Q8TPD1 ^@ Cofactor|||Function|||Subunit ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/188937:MA_RS12060 ^@ http://purl.uniprot.org/uniprot/Q8TNG3 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/188937:MA_RS24045 ^@ http://purl.uniprot.org/uniprot/Q8THA9 ^@ Function|||Similarity ^@ Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.|||Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.|||In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.|||In the N-terminal section; belongs to the formaldehyde-activating enzyme family. http://togogenome.org/gene/188937:MA_RS20140 ^@ http://purl.uniprot.org/uniprot/Q8TJC5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CdhB family.|||Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).|||Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation. http://togogenome.org/gene/188937:MA_RS22325 ^@ http://purl.uniprot.org/uniprot/Q8TI80 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/188937:MA_RS15820 ^@ http://purl.uniprot.org/uniprot/Q8TLL4 ^@ Similarity ^@ In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/188937:MA_RS03395 ^@ http://purl.uniprot.org/uniprot/P61931 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/188937:MA_RS06905 ^@ http://purl.uniprot.org/uniprot/Q8TR53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS16965 ^@ http://purl.uniprot.org/uniprot/Q8TKZ1 ^@ Caution|||Function|||Similarity ^@ Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.|||Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/188937:MA_RS23540 ^@ http://purl.uniprot.org/uniprot/Q8THK1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. RaSEA family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Forms a robust complex with the archaeosine synthase alpha subunit ArcS (PubMed:31740832). This complex likely consists of an alpha(2)beta(2) heterotetrameric structure (By similarity).|||Radical SAM enzyme involved in the synthesis of archaeosine, a modified nucleoside present in the dihydrouridine loop (D-loop) of archaeal tRNAs. Catalyzes the cleavage of the C(epsilon)-N bond of the lysine moiety of q0kN15-tRNA, leading to the formation of archaeosine at position 15 in tRNAs. http://togogenome.org/gene/188937:MA_RS20975 ^@ http://purl.uniprot.org/uniprot/Q8TIX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). http://togogenome.org/gene/188937:MA_RS02340 ^@ http://purl.uniprot.org/uniprot/Q8TTI6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS18415 ^@ http://purl.uniprot.org/uniprot/Q8TK89 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.|||Belongs to the TiaS family.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS24190 ^@ http://purl.uniprot.org/uniprot/Q8TH86 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/188937:MA_RS23065 ^@ http://purl.uniprot.org/uniprot/Q8THU8 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/188937:MA_RS02890 ^@ http://purl.uniprot.org/uniprot/Q8TT87 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/188937:MA_RS00765 ^@ http://purl.uniprot.org/uniprot/P58867 ^@ Function|||Similarity|||Subunit ^@ Acts as a methyl group carrier between MtmB and MtbA.|||Belongs to the methylamine corrinoid protein family.|||Can form a complex with MtmB. http://togogenome.org/gene/188937:MA_RS20260 ^@ http://purl.uniprot.org/uniprot/Q8TJA3 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/188937:MA_RS21690 ^@ http://purl.uniprot.org/uniprot/Q8TIJ2 ^@ Function|||Similarity ^@ Belongs to the V-ATPase F subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/188937:MA_RS09070 ^@ http://purl.uniprot.org/uniprot/Q8TQ05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). http://togogenome.org/gene/188937:MA_RS05285 ^@ http://purl.uniprot.org/uniprot/Q8TH44 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 [4Fe-4S] cluster.|||Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).|||Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. http://togogenome.org/gene/188937:MA_RS16195 ^@ http://purl.uniprot.org/uniprot/Q8TLE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS06500 ^@ http://purl.uniprot.org/uniprot/Q8TRC8 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/188937:MA_RS10065 ^@ http://purl.uniprot.org/uniprot/Q8TPI0 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated Csm2 family.|||This subunit may be involved in monitoring complementarity of crRNA and target RNA. http://togogenome.org/gene/188937:MA_RS05300 ^@ http://purl.uniprot.org/uniprot/Q8TRZ6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the CdhC family.|||Binds 1 [Ni-Fe-S] cluster.|||Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8) (Potential).|||Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex). http://togogenome.org/gene/188937:MA_RS19685 ^@ http://purl.uniprot.org/uniprot/Q8TJK4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.|||Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.|||Homodimer. http://togogenome.org/gene/188937:MA_RS23990 ^@ http://purl.uniprot.org/uniprot/Q8THC0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS09255 ^@ http://purl.uniprot.org/uniprot/Q8TPX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/188937:MA_RS05775 ^@ http://purl.uniprot.org/uniprot/Q8TRR2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/188937:MA_RS22800 ^@ http://purl.uniprot.org/uniprot/Q8THZ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS01175 ^@ http://purl.uniprot.org/uniprot/Q8TU55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS02360 ^@ http://purl.uniprot.org/uniprot/Q8TTI2 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/188937:MA_RS21960 ^@ http://purl.uniprot.org/uniprot/Q8TIE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS12550 ^@ http://purl.uniprot.org/uniprot/Q8TN75 ^@ Similarity ^@ Belongs to the HsdR family. http://togogenome.org/gene/188937:MA_RS21320 ^@ http://purl.uniprot.org/uniprot/Q8TIQ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS18740 ^@ http://purl.uniprot.org/uniprot/Q8TK32 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/188937:MA_RS23745 ^@ http://purl.uniprot.org/uniprot/Q8THG2 ^@ Activity Regulation|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.|||Belongs to the RuBisCO large chain family. Type III subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.|||Homodimer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.|||Reversibly inhibited by O(2). http://togogenome.org/gene/188937:MA_RS02775 ^@ http://purl.uniprot.org/uniprot/Q8TTA8 ^@ Function|||Similarity|||Subunit ^@ Acts probably as a methyl group carrier between MttB and either MtbA or MtaA.|||Belongs to the methylamine corrinoid protein family.|||Can form a complex with MttB. http://togogenome.org/gene/188937:MA_RS08715 ^@ http://purl.uniprot.org/uniprot/Q8TQ70 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/188937:MA_RS16775 ^@ http://purl.uniprot.org/uniprot/Q8TL28 ^@ Activity Regulation|||Cofactor|||Domain|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the peptidase M43B family.|||Binds 1 zinc ion per subunit.|||Binds 2 calcium ions per subunit.|||Consists of two subdomains separated by an active site cleft containing the catalytic zinc ion.|||Inhibited by EDTA, excess zinc, and also significantly by batimastat in vitro. Is not inhibited by other metalloprotease inhibitors like phosphoramidon, captopril and galardine or those targeting other classes of proteases.|||Metalloprotease which in vitro specifically cleaves IGFBP-2 to -6, insulin, and extracellular matrix proteins but not IGFBP-1 or IGF-II. Shows a preference for substrates with an arginine in the P1' position, the first position downstream of the scissile bond.|||Monomer.|||The inactive zymogen pro-ulilysin undergoes calcium-mediated autolytic activation to the mature ulilysin. Autoproteolytic activation entails removal of the first 60 residues and of a highly charged 20-residue C-terminal tail. http://togogenome.org/gene/188937:MA_RS07115 ^@ http://purl.uniprot.org/uniprot/Q8TR14 ^@ Function|||Similarity|||Subunit ^@ Belongs to the diphthine synthase family.|||Homodimer.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/188937:MA_RS17060 ^@ http://purl.uniprot.org/uniprot/Q8TKX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTH2 family.|||Cytoplasm|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/188937:MA_RS15390 ^@ http://purl.uniprot.org/uniprot/Q8TLT8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS16025 ^@ http://purl.uniprot.org/uniprot/Q8TLH2 ^@ Function|||Similarity ^@ Belongs to the CheD family.|||Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis. http://togogenome.org/gene/188937:MA_RS05485 ^@ http://purl.uniprot.org/uniprot/Q8TRW4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS06550 ^@ http://purl.uniprot.org/uniprot/Q8TRB7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds at least 2 Zn(2+) per subunit.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/188937:MA_RS20200 ^@ http://purl.uniprot.org/uniprot/Q8TJB5 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/188937:MA_RS08245 ^@ http://purl.uniprot.org/uniprot/Q8TQF7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6B family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/188937:MA_RS05290 ^@ http://purl.uniprot.org/uniprot/Q8TRZ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CdhD family.|||Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8) (Potential).|||Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex (By similarity). http://togogenome.org/gene/188937:MA_RS24040 ^@ http://purl.uniprot.org/uniprot/Q8THB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homotetramer; dimer of dimers.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/188937:MA_RS00460 ^@ http://purl.uniprot.org/uniprot/Q8TUH7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.|||Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).|||Homotetramer. Interacts with SepCysS. http://togogenome.org/gene/188937:MA_RS03080 ^@ http://purl.uniprot.org/uniprot/Q8TT52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm http://togogenome.org/gene/188937:MA_RS00720 ^@ http://purl.uniprot.org/uniprot/Q8TUD1 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/188937:MA_RS05935 ^@ http://purl.uniprot.org/uniprot/Q8TRN5 ^@ Similarity ^@ Belongs to the HupF/HypC family. http://togogenome.org/gene/188937:MA_RS05700 ^@ http://purl.uniprot.org/uniprot/Q8TRS6 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/188937:MA_RS18325 ^@ http://purl.uniprot.org/uniprot/Q8TH29 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/188937:MA_RS20135 ^@ http://purl.uniprot.org/uniprot/Q8TJC6 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the Ni-containing carbon monoxide dehydrogenase family.|||Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.|||Binds 7 [4Fe-4S] clusters per heterotetramer.|||Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.|||Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).|||Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. http://togogenome.org/gene/188937:MA_RS01595 ^@ http://purl.uniprot.org/uniprot/Q8TTX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS15365 ^@ http://purl.uniprot.org/uniprot/Q8TLU3 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/188937:MA_RS06110 ^@ http://purl.uniprot.org/uniprot/Q8TRK1 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.|||Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/188937:MA_RS05350 ^@ http://purl.uniprot.org/uniprot/Q8TRY8 ^@ Function|||Subunit ^@ Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/188937:MA_RS01140 ^@ http://purl.uniprot.org/uniprot/Q8TU60 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/188937:MA_RS06270 ^@ http://purl.uniprot.org/uniprot/Q8TH41 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the NifH/BchL/ChlL family.|||Binds 1 [4Fe-4S] cluster per dimer.|||Homodimer.|||The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.|||The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.|||The reversible ADP-ribosylation of Arg-100 inactivates the nitrogenase reductase and regulates nitrogenase activity. http://togogenome.org/gene/188937:MA_RS20235 ^@ http://purl.uniprot.org/uniprot/Q8TJA8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.|||Cell membrane|||Homodimer.|||Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. http://togogenome.org/gene/188937:MA_RS11670 ^@ http://purl.uniprot.org/uniprot/Q8TNN3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS01645 ^@ http://purl.uniprot.org/uniprot/Q8TTW6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the FwdB family.|||Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.|||This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG. http://togogenome.org/gene/188937:MA_RS03740 ^@ http://purl.uniprot.org/uniprot/Q8TST1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CofD family.|||Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.|||Homodimer. http://togogenome.org/gene/188937:MA_RS02255 ^@ http://purl.uniprot.org/uniprot/Q8TTK1 ^@ Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Homodimer. http://togogenome.org/gene/188937:MA_RS18060 ^@ http://purl.uniprot.org/uniprot/Q8TKE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS09975 ^@ http://purl.uniprot.org/uniprot/Q8TPJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS22315 ^@ http://purl.uniprot.org/uniprot/Q8TI82 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/188937:MA_RS01455 ^@ http://purl.uniprot.org/uniprot/Q8TU01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrC family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/188937:MA_RS07500 ^@ http://purl.uniprot.org/uniprot/Q8TQU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.|||Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure. http://togogenome.org/gene/188937:MA_RS00700 ^@ http://purl.uniprot.org/uniprot/Q8TUD5 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/188937:MA_RS23730 ^@ http://purl.uniprot.org/uniprot/Q8THG5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal DNA polymerase II family.|||Heterodimer of a large subunit and a small subunit.|||Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity). http://togogenome.org/gene/188937:MA_RS18605 ^@ http://purl.uniprot.org/uniprot/P58847 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the carbohydrate kinase PfkC family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS13190 ^@ http://purl.uniprot.org/uniprot/Q8TMW3 ^@ Similarity ^@ Belongs to the gamma-class carbonic anhydrase family. http://togogenome.org/gene/188937:MA_RS07130 ^@ http://purl.uniprot.org/uniprot/Q8TR11 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/188937:MA_RS06055 ^@ http://purl.uniprot.org/uniprot/Q8TRL2 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the MRE11/RAD32 family.|||Binds 2 manganese ions per subunit.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Nuclease activity is regulated by Rad50.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. http://togogenome.org/gene/188937:MA_RS19255 ^@ http://purl.uniprot.org/uniprot/Q8TJT1 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS31 family.|||Binds 1 zinc ion per subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/188937:MA_RS14125 ^@ http://purl.uniprot.org/uniprot/Q8TMF9 ^@ Similarity ^@ Belongs to the flavodoxin family. http://togogenome.org/gene/188937:MA_RS07360 ^@ http://purl.uniprot.org/uniprot/Q8TQW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). http://togogenome.org/gene/188937:MA_RS09940 ^@ http://purl.uniprot.org/uniprot/Q8TPK6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS08930 ^@ http://purl.uniprot.org/uniprot/Q8TQ31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mediates influx of magnesium ions.|||Membrane http://togogenome.org/gene/188937:MA_RS23765 ^@ http://purl.uniprot.org/uniprot/Q8THF9 ^@ Similarity ^@ Belongs to the methylamine corrinoid protein family. http://togogenome.org/gene/188937:MA_RS22250 ^@ http://purl.uniprot.org/uniprot/Q8TI95 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/188937:MA_RS04320 ^@ http://purl.uniprot.org/uniprot/Q8TSG7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Methanosarcinales S-layer protein family.|||Cell membrane|||Glycosylated.|||S-layer|||S-layer protein. The S-layer is a paracrystalline mono-layered assembly of proteins which coat the surface of the cell. http://togogenome.org/gene/188937:MA_RS01445 ^@ http://purl.uniprot.org/uniprot/Q8TU03 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrA family.|||Binds 1 5-hydroxybenzimidazolylcobamide group.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/188937:MA_RS20390 ^@ http://purl.uniprot.org/uniprot/Q8TJ82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS03910 ^@ http://purl.uniprot.org/uniprot/Q8TSP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family. YhdE subfamily.|||Cytoplasm|||Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/188937:MA_RS14880 ^@ http://purl.uniprot.org/uniprot/Q8TM33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS23095 ^@ http://purl.uniprot.org/uniprot/Q8THU2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeosine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs. http://togogenome.org/gene/188937:MA_RS00530 ^@ http://purl.uniprot.org/uniprot/Q8TUG6 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the HepT RNase toxin family.|||Homodimer, probably forms a complex with cognate antitoxin MA_102.|||Modified by cognate antitoxin MA_102; probably at least 2 successive AMPylation events occur on Tyr-84.|||Probable toxic component of a putative type VII toxin-antitoxin (TA) system, probably an RNase. Probably neutralized by cognate antitoxin MA_102. Neutralization may be due to AMPylation by MA_102. http://togogenome.org/gene/188937:MA_RS20355 ^@ http://purl.uniprot.org/uniprot/Q8TJ88 ^@ Function|||Similarity ^@ Belongs to the NifD/NifK/NifE/NifN family.|||This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor). http://togogenome.org/gene/188937:MA_RS21130 ^@ http://purl.uniprot.org/uniprot/Q8TIU3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/188937:MA_RS16565 ^@ http://purl.uniprot.org/uniprot/Q8TL71 ^@ Similarity|||Subunit ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Homohexamer. http://togogenome.org/gene/188937:MA_RS14350 ^@ http://purl.uniprot.org/uniprot/Q8TH54 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/188937:MA_RS18925 ^@ http://purl.uniprot.org/uniprot/Q8TJZ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CbiX family. CbiXS subfamily.|||Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis (Potential). Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation (PubMed:27846569). Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin (PubMed:27846569).|||Homotetramer; dimer of dimers. http://togogenome.org/gene/188937:MA_RS04875 ^@ http://purl.uniprot.org/uniprot/Q8TS66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. http://togogenome.org/gene/188937:MA_RS10310 ^@ http://purl.uniprot.org/uniprot/Q8TPD4 ^@ Similarity ^@ Belongs to the UPF0758 family. http://togogenome.org/gene/188937:MA_RS21675 ^@ http://purl.uniprot.org/uniprot/Q8TIJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane http://togogenome.org/gene/188937:MA_RS17875 ^@ http://purl.uniprot.org/uniprot/Q8TKI1 ^@ Similarity ^@ Belongs to the UPF0677 family. http://togogenome.org/gene/188937:MA_RS00550 ^@ http://purl.uniprot.org/uniprot/Q8TUG3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/188937:MA_RS18515 ^@ http://purl.uniprot.org/uniprot/Q8TK71 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family.|||Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. http://togogenome.org/gene/188937:MA_RS04040 ^@ http://purl.uniprot.org/uniprot/Q8TSM4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS03195 ^@ http://purl.uniprot.org/uniprot/Q8TT31 ^@ Similarity ^@ Belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/188937:MA_RS06415 ^@ http://purl.uniprot.org/uniprot/Q8TRE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/188937:MA_RS05765 ^@ http://purl.uniprot.org/uniprot/Q8TRR4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS24210 ^@ http://purl.uniprot.org/uniprot/Q8TH81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/188937:MA_RS07815 ^@ http://purl.uniprot.org/uniprot/Q8TQN4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS23485 ^@ http://purl.uniprot.org/uniprot/Q8THL2 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.|||Heterooligomer of catalytic and regulatory chains. http://togogenome.org/gene/188937:MA_RS23830 ^@ http://purl.uniprot.org/uniprot/Q8THE6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS14755 ^@ http://purl.uniprot.org/uniprot/Q8TM54 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the transcriptional regulatory CopG/NikR family.|||Binds 1 nickel ion per subunit.|||Transcriptional regulator. http://togogenome.org/gene/188937:MA_RS07695 ^@ http://purl.uniprot.org/uniprot/Q8TQQ8 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/188937:MA_RS10790 ^@ http://purl.uniprot.org/uniprot/Q8TP42 ^@ Cofactor|||Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/188937:MA_RS10300 ^@ http://purl.uniprot.org/uniprot/Q8TPD6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MobA family.|||Cytoplasm|||The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.|||Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. http://togogenome.org/gene/188937:MA_RS18920 ^@ http://purl.uniprot.org/uniprot/Q8TJZ6 ^@ Function|||Similarity ^@ Belongs to the MurCDEF family.|||Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the activation the g-propionate side chain of 15,17(3)-seco-F430-17(3)-acid (seco-F430) for intramolecular C-C bond formation to yield the carbocyclic F ring of coenzyme F430. http://togogenome.org/gene/188937:MA_RS00710 ^@ http://purl.uniprot.org/uniprot/Q8TUD3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the CofE family.|||Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.|||Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.|||Homodimer.|||Monovalent cation. The ion could be potassium. http://togogenome.org/gene/188937:MA_RS14135 ^@ http://purl.uniprot.org/uniprot/Q8TMF7 ^@ Function ^@ Involved in the transposition of the insertion sequence IS5. http://togogenome.org/gene/188937:MA_RS20345 ^@ http://purl.uniprot.org/uniprot/Q8TJ90 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NifD/NifK/NifE/NifN family.|||Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).|||This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation. http://togogenome.org/gene/188937:MA_RS10550 ^@ http://purl.uniprot.org/uniprot/Q8TH29 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/188937:MA_RS22995 ^@ http://purl.uniprot.org/uniprot/Q8THW2 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the Ni-containing carbon monoxide dehydrogenase family.|||Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.|||Binds 7 [4Fe-4S] clusters per heterotetramer.|||Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.|||Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).|||Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. http://togogenome.org/gene/188937:MA_RS19240 ^@ http://purl.uniprot.org/uniprot/Q8TJT4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt4 family.|||Heterodimer composed of Spt4 and Spt5.|||Stimulates transcription elongation. http://togogenome.org/gene/188937:MA_RS06090 ^@ http://purl.uniprot.org/uniprot/Q8TRK5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/188937:MA_RS01925 ^@ http://purl.uniprot.org/uniprot/Q8TTR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS15770 ^@ http://purl.uniprot.org/uniprot/Q8TLM4 ^@ Cofactor|||Similarity ^@ Belongs to the PdaD family.|||Binds 1 pyruvoyl group covalently per subunit. http://togogenome.org/gene/188937:MA_RS24030 ^@ http://purl.uniprot.org/uniprot/Q8THB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/188937:MA_RS14970 ^@ http://purl.uniprot.org/uniprot/Q8TM19 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the THI4 family.|||Homooctamer; tetramer of dimers.|||Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.|||This protein was originally thought to have ribose 1,5-bisphosphate isomerase activity despite the fact that some recombinant ortholog proteins were not active in vitro (PubMed:15375115, PubMed:17303759). Moreover, another protein from M.acetivorans likely possesses this activity (MA_0379). Finally, a thiamine synthase activity has been shown for the ortholog protein in M.jannaschii. http://togogenome.org/gene/188937:MA_RS22835 ^@ http://purl.uniprot.org/uniprot/Q8THZ2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS07680 ^@ http://purl.uniprot.org/uniprot/Q8TQR0 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/188937:MA_RS20995 ^@ http://purl.uniprot.org/uniprot/Q8TIW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS15775 ^@ http://purl.uniprot.org/uniprot/Q8TLM3 ^@ Function|||Similarity ^@ Belongs to the deoxyhypusine synthase family.|||Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. http://togogenome.org/gene/188937:MA_RS15305 ^@ http://purl.uniprot.org/uniprot/Q8TLV2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS20080 ^@ http://purl.uniprot.org/uniprot/Q8TJD5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity). http://togogenome.org/gene/188937:MA_RS06460 ^@ http://purl.uniprot.org/uniprot/Q8TRD6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS23975 ^@ http://purl.uniprot.org/uniprot/Q8THC3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). http://togogenome.org/gene/188937:MA_RS05780 ^@ http://purl.uniprot.org/uniprot/Q8TRR1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/188937:MA_RS23615 ^@ http://purl.uniprot.org/uniprot/Q8TH29 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/188937:MA_RS01430 ^@ http://purl.uniprot.org/uniprot/Q8TU06 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MtrH family.|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/188937:MA_RS03575 ^@ http://purl.uniprot.org/uniprot/Q8TSW4 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/188937:MA_RS02370 ^@ http://purl.uniprot.org/uniprot/Q8TTI0 ^@ Similarity ^@ Belongs to the glycosyltransferase 28 family. http://togogenome.org/gene/188937:MA_RS19205 ^@ http://purl.uniprot.org/uniprot/Q8TJU1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycerol-1-phosphate dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS00920 ^@ http://purl.uniprot.org/uniprot/Q8TUA3 ^@ Similarity ^@ Belongs to the UPF0677 family. http://togogenome.org/gene/188937:MA_RS00500 ^@ http://purl.uniprot.org/uniprot/Q8TUH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS00820 ^@ http://purl.uniprot.org/uniprot/Q8TUB9 ^@ Cofactor|||Disruption Phenotype|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. PylB family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the isomerization of L-lysine to (2R,3R)-3-methylornithine via a radical-based mechanism (Probable). Is required for the biosynthesis of pyrrolysine.|||Cells lacking this gene are unable to translate UAG as pyrrolysine, and do not produce pyrrolysine. http://togogenome.org/gene/188937:MA_RS16010 ^@ http://purl.uniprot.org/uniprot/Q8TLH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Archaeal flagellum|||Belongs to the archaeal flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella. http://togogenome.org/gene/188937:MA_RS20145 ^@ http://purl.uniprot.org/uniprot/Q8TJC4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the CdhC family.|||Binds 1 [Ni-Fe-S] cluster.|||Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8) (Potential).|||Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex). http://togogenome.org/gene/188937:MA_RS06315 ^@ http://purl.uniprot.org/uniprot/Q8TRG6 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/188937:MA_RS03170 ^@ http://purl.uniprot.org/uniprot/Q8TT36 ^@ Function|||Similarity|||Subunit ^@ Belongs to the isopentenyl phosphate kinase family.|||Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.|||Homodimer. http://togogenome.org/gene/188937:MA_RS01290 ^@ http://purl.uniprot.org/uniprot/Q8TU33 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/188937:MA_RS23725 ^@ http://purl.uniprot.org/uniprot/Q8THG6 ^@ Cofactor|||Disruption Phenotype|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MCR alpha subunit C-methyltransferase family.|||Binds at least 1 [4Fe-4S] cluster. This cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cells lacking this gene produce an active MCR lacking the C(5)-methylation of the respective arginine residue. The mutant strain shows impaired growth under stress conditions, such as the presence of 0.2 mM hydrogen peroxide (H2O2) or elevated temperature (42 degrees Celsius).|||Radical SAM methyltransferase that is responsible for the C(5)-methylation of 'Arg-285' of the methyl-coenzyme M reductase (MCR) subunit alpha McrA. This post-translational methylation, despite being not essential in vivo, plays a role for the stability and structural integrity of MCR. http://togogenome.org/gene/188937:MA_RS21440 ^@ http://purl.uniprot.org/uniprot/Q8TIN7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/188937:MA_RS09245 ^@ http://purl.uniprot.org/uniprot/Q8TPX6 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/188937:MA_RS14890 ^@ http://purl.uniprot.org/uniprot/Q8TM31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS07925 ^@ http://purl.uniprot.org/uniprot/Q8TQL4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/188937:MA_RS23705 ^@ http://purl.uniprot.org/uniprot/Q8THH0 ^@ Similarity|||Subunit ^@ Belongs to the methyl-coenzyme M reductase gamma subunit family.|||Hexamer of two alpha, two beta, and two gamma chains.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers. http://togogenome.org/gene/188937:MA_RS20970 ^@ http://purl.uniprot.org/uniprot/Q8TIX1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS13090 ^@ http://purl.uniprot.org/uniprot/Q8TMY0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/188937:MA_RS20810 ^@ http://purl.uniprot.org/uniprot/Q8TJ01 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/188937:MA_RS03975 ^@ http://purl.uniprot.org/uniprot/Q8TSN5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/188937:MA_RS01305 ^@ http://purl.uniprot.org/uniprot/Q8TU30 ^@ Similarity ^@ Belongs to the UPF0107 family. http://togogenome.org/gene/188937:MA_RS06120 ^@ http://purl.uniprot.org/uniprot/Q8TRJ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS20635 ^@ http://purl.uniprot.org/uniprot/Q8TJ32 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/188937:MA_RS03775 ^@ http://purl.uniprot.org/uniprot/Q8TSS4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/188937:MA_RS23560 ^@ http://purl.uniprot.org/uniprot/Q8THJ7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase IV family.|||Binds 1 Fe(2+) ion per subunit.|||Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.|||Homodimer. http://togogenome.org/gene/188937:MA_RS18065 ^@ http://purl.uniprot.org/uniprot/Q8TKE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS05785 ^@ http://purl.uniprot.org/uniprot/Q8TRR0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/188937:MA_RS05260 ^@ http://purl.uniprot.org/uniprot/Q8TS02 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS01410 ^@ http://purl.uniprot.org/uniprot/Q8TU11 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/188937:MA_RS05830 ^@ http://purl.uniprot.org/uniprot/Q8TRQ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS00840 ^@ http://purl.uniprot.org/uniprot/Q8TUB6 ^@ Similarity ^@ Belongs to the UPF0251 family. http://togogenome.org/gene/188937:MA_RS04945 ^@ http://purl.uniprot.org/uniprot/Q8TS54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/188937:MA_RS04410 ^@ http://purl.uniprot.org/uniprot/Q8TSF2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS08330 ^@ http://purl.uniprot.org/uniprot/Q8TQE2 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/188937:MA_RS06005 ^@ http://purl.uniprot.org/uniprot/Q8TRM2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/188937:MA_RS15830 ^@ http://purl.uniprot.org/uniprot/Q8TLL2 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/188937:MA_RS09035 ^@ http://purl.uniprot.org/uniprot/Q8TQ12 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/188937:MA_RS01490 ^@ http://purl.uniprot.org/uniprot/Q8TTZ5 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily. http://togogenome.org/gene/188937:MA_RS04750 ^@ http://purl.uniprot.org/uniprot/Q8TS88 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/188937:MA_RS23480 ^@ http://purl.uniprot.org/uniprot/Q8THL3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/188937:MA_RS00600 ^@ http://purl.uniprot.org/uniprot/Q8TUF2 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).|||Cell membrane|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. http://togogenome.org/gene/188937:MA_RS17840 ^@ http://purl.uniprot.org/uniprot/Q8TKI9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS1 family. http://togogenome.org/gene/188937:MA_RS23275 ^@ http://purl.uniprot.org/uniprot/Q8THQ5 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/188937:MA_RS07505 ^@ http://purl.uniprot.org/uniprot/Q8TQU3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/188937:MA_RS05755 ^@ http://purl.uniprot.org/uniprot/Q8TRR5 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.|||Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/188937:MA_RS09470 ^@ http://purl.uniprot.org/uniprot/Q8TPT6 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/188937:MA_RS15670 ^@ http://purl.uniprot.org/uniprot/Q8TLP6 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/188937:MA_RS03055 ^@ http://purl.uniprot.org/uniprot/Q8TT56 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/188937:MA_RS15665 ^@ http://purl.uniprot.org/uniprot/Q8TLP7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the anthranilate synthase component I family.|||Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).|||Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. http://togogenome.org/gene/188937:MA_RS09480 ^@ http://purl.uniprot.org/uniprot/Q8TPT4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the L-aspartate semialdehyde sulfurtransferase family.|||Forms homodimers. May form a complex with MA_1822.|||Required for O-acetylhomoserine sulfhydrylase (OAHS)-independent homocysteine (Hcy) biosynthesis (PubMed:25315403, PubMed:25938369). Together with MA_1822, catalyzes the condensation of sulfide with aspartate semialdehyde to generate homocysteine (Probable). Likely functions through persulfide intermediate (PubMed:28165724). http://togogenome.org/gene/188937:MA_RS11325 ^@ http://purl.uniprot.org/uniprot/Q8TNU5 ^@ Similarity ^@ Belongs to the glucose-1-phosphate thymidylyltransferase family. http://togogenome.org/gene/188937:MA_RS17570 ^@ http://purl.uniprot.org/uniprot/Q8TKN4 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/188937:MA_RS11410 ^@ http://purl.uniprot.org/uniprot/Q8TH54 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/188937:MA_RS18280 ^@ http://purl.uniprot.org/uniprot/Q8TKB4 ^@ Cofactor|||Similarity ^@ Belongs to the PdaD family.|||Binds 1 pyruvoyl group covalently per subunit. http://togogenome.org/gene/188937:MA_RS21735 ^@ http://purl.uniprot.org/uniprot/Q8TII5 ^@ Similarity ^@ Belongs to the methylamine corrinoid protein family. http://togogenome.org/gene/188937:MA_RS02855 ^@ http://purl.uniprot.org/uniprot/Q8TT93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.|||Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins (By similarity).|||Cytoplasm http://togogenome.org/gene/188937:MA_RS19115 ^@ http://purl.uniprot.org/uniprot/Q8TJW0 ^@ Function ^@ CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/188937:MA_RS04785 ^@ http://purl.uniprot.org/uniprot/Q8TS82 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/188937:MA_RS11835 ^@ http://purl.uniprot.org/uniprot/Q8TNK3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS14095 ^@ http://purl.uniprot.org/uniprot/Q8TMG4 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/188937:MA_RS03050 ^@ http://purl.uniprot.org/uniprot/Q8TT57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS20455 ^@ http://purl.uniprot.org/uniprot/Q8TJ70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS10080 ^@ http://purl.uniprot.org/uniprot/Q8TPH7 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated Csm5 family.|||This subunit might be involved in maturation of a crRNA intermediate to its mature form. http://togogenome.org/gene/188937:MA_RS19535 ^@ http://purl.uniprot.org/uniprot/Q8TJN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MntP (TC 9.B.29) family.|||Cell membrane|||Probably functions as a manganese efflux pump. http://togogenome.org/gene/188937:MA_RS13920 ^@ http://purl.uniprot.org/uniprot/Q8TMI8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/188937:MA_RS15685 ^@ http://purl.uniprot.org/uniprot/Q8TLP3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/188937:MA_RS23340 ^@ http://purl.uniprot.org/uniprot/Q8THP2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/188937:MA_RS19560 ^@ http://purl.uniprot.org/uniprot/Q8TJM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/188937:MA_RS01480 ^@ http://purl.uniprot.org/uniprot/Q8TTZ7 ^@ Function|||Similarity ^@ Belongs to the TBP family.|||General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. http://togogenome.org/gene/188937:MA_RS01300 ^@ http://purl.uniprot.org/uniprot/Q8TU31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS24185 ^@ http://purl.uniprot.org/uniprot/Q8TH87 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the archaeal DnaG primase family.|||Binds two Mg(2+) per subunit.|||Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome. http://togogenome.org/gene/188937:MA_RS02035 ^@ http://purl.uniprot.org/uniprot/Q8TTN9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS22965 ^@ http://purl.uniprot.org/uniprot/F1SVF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/188937:MA_RS14535 ^@ http://purl.uniprot.org/uniprot/Q8TM90 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS08875 ^@ http://purl.uniprot.org/uniprot/Q8TQ42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCH family.|||Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).|||Cytoplasm http://togogenome.org/gene/188937:MA_RS07725 ^@ http://purl.uniprot.org/uniprot/Q8TQQ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CofC family.|||Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.|||Homodimer. http://togogenome.org/gene/188937:MA_RS13890 ^@ http://purl.uniprot.org/uniprot/Q8TMJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/188937:MA_RS12670 ^@ http://purl.uniprot.org/uniprot/Q8TN53 ^@ Similarity ^@ Belongs to the ATPase epsilon chain family. http://togogenome.org/gene/188937:MA_RS06125 ^@ http://purl.uniprot.org/uniprot/Q8TRJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS03155 ^@ http://purl.uniprot.org/uniprot/Q8TT39 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/188937:MA_RS17460 ^@ http://purl.uniprot.org/uniprot/P58838 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/188937:MA_RS19310 ^@ http://purl.uniprot.org/uniprot/Q8TJS1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/188937:MA_RS20645 ^@ http://purl.uniprot.org/uniprot/Q8TJ31 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS03470 ^@ http://purl.uniprot.org/uniprot/Q8TSY3 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrB/RnfD family.|||Cell membrane|||Deletion of the rnf operon abolishes growth on acetate and ferredoxin:heterodisulfide oxidoreductase-coupled Na(+) transport.|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Catalyzes Na(+) transport, most probably coupled to electron transfer from reduced ferredoxin to methanophenazine and heterodisulfide reductase. Involved in heterodisulfide reduction during methanogenesis from acetate.|||The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/188937:MA_RS18085 ^@ http://purl.uniprot.org/uniprot/Q8TKE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS01180 ^@ http://purl.uniprot.org/uniprot/P58878 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS13705 ^@ http://purl.uniprot.org/uniprot/Q8TMM5 ^@ Similarity ^@ Belongs to the LOR family. http://togogenome.org/gene/188937:MA_RS23965 ^@ http://purl.uniprot.org/uniprot/Q8THC5 ^@ Function|||Similarity ^@ Belongs to the archaeal-type DHQ synthase family.|||Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis. http://togogenome.org/gene/188937:MA_RS21655 ^@ http://purl.uniprot.org/uniprot/Q8TIJ9 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/188937:MA_RS17550 ^@ http://purl.uniprot.org/uniprot/Q8TH26 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/188937:MA_RS06305 ^@ http://purl.uniprot.org/uniprot/Q8TRG7 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/188937:MA_RS17260 ^@ http://purl.uniprot.org/uniprot/Q8TKU0 ^@ Similarity ^@ Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family. http://togogenome.org/gene/188937:MA_RS22565 ^@ http://purl.uniprot.org/uniprot/Q8TI36 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS22170 ^@ http://purl.uniprot.org/uniprot/Q8TIA9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/188937:MA_RS22120 ^@ http://purl.uniprot.org/uniprot/Q8TIB9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HdrC family.|||Binds 2 [4Fe-4S] cluster.|||Cytoplasm|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Catalyzes the transfer of electrons from ferredoxin to CoM-S-S-CoB during methanogenesis from acetate. Electrons transfer from ferredoxin to CoM-S-S-CoB via HdrA2, HdrC2 and HdrB2. In addition, the complex can use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB-CoM heterodisulfide. This activity may take place during Fe(III)-dependent anaerobic methane oxidation.|||The ferredoxin/F(420)H(2)-dependent CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA2, HdrB2 and HdrC2. http://togogenome.org/gene/188937:MA_RS12625 ^@ http://purl.uniprot.org/uniprot/Q8TN62 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/188937:MA_RS07860 ^@ http://purl.uniprot.org/uniprot/Q8TQM6 ^@ Function|||Similarity ^@ Belongs to the UPF0330 family.|||Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC3 (Potential). http://togogenome.org/gene/188937:MA_RS01720 ^@ http://purl.uniprot.org/uniprot/Q8TTV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/188937:MA_RS08725 ^@ http://purl.uniprot.org/uniprot/Q8TQ69 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose 5-phosphate isomerase family.|||Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.|||Homodimer. http://togogenome.org/gene/188937:MA_RS00435 ^@ http://purl.uniprot.org/uniprot/Q8TUI2 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/188937:MA_RS08565 ^@ http://purl.uniprot.org/uniprot/Q8TQ99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS00575 ^@ http://purl.uniprot.org/uniprot/Q8TUF8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. http://togogenome.org/gene/188937:MA_RS23345 ^@ http://purl.uniprot.org/uniprot/Q8THP1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/188937:MA_RS07525 ^@ http://purl.uniprot.org/uniprot/Q8TQT9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS00215 ^@ http://purl.uniprot.org/uniprot/Q8TUM4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm|||Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.|||Heterodimer of two subunits, one of which binds GTP. http://togogenome.org/gene/188937:MA_RS04970 ^@ http://purl.uniprot.org/uniprot/Q8TS49 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/188937:MA_RS14045 ^@ http://purl.uniprot.org/uniprot/Q8TMH1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS08025 ^@ http://purl.uniprot.org/uniprot/Q8TQJ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS03320 ^@ http://purl.uniprot.org/uniprot/Q8TGX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/188937:MA_RS03135 ^@ http://purl.uniprot.org/uniprot/Q8TT42 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/188937:MA_RS20890 ^@ http://purl.uniprot.org/uniprot/Q8TIY5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity). http://togogenome.org/gene/188937:MA_RS23740 ^@ http://purl.uniprot.org/uniprot/Q8THG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUA5 family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/188937:MA_RS15190 ^@ http://purl.uniprot.org/uniprot/Q8TLX7 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).|||Cytoplasm|||Homodimer.|||The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself. http://togogenome.org/gene/188937:MA_RS22055 ^@ http://purl.uniprot.org/uniprot/P61935 ^@ Similarity ^@ Belongs to the UPF0228 family. http://togogenome.org/gene/188937:MA_RS01500 ^@ http://purl.uniprot.org/uniprot/Q8TTZ3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS02420 ^@ http://purl.uniprot.org/uniprot/Q8TTH2 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/188937:MA_RS00605 ^@ http://purl.uniprot.org/uniprot/Q8TUF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/188937:MA_RS23685 ^@ http://purl.uniprot.org/uniprot/Q8THH4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.|||Cytoplasm|||May catalyze the biosynthesis of dTMP using an unknown cosubstrate.|||Monomer. http://togogenome.org/gene/188937:MA_RS03425 ^@ http://purl.uniprot.org/uniprot/Q8TSZ2 ^@ Function|||Similarity|||Subunit ^@ Associates with stalled 50S ribosomal subunits.|||Belongs to the NEMF family.|||Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation. http://togogenome.org/gene/188937:MA_RS19620 ^@ http://purl.uniprot.org/uniprot/Q8TJL6 ^@ Similarity|||Subunit ^@ Belongs to the CMP-NeuNAc synthase family.|||Belongs to the KdsC family.|||Homotetramer. http://togogenome.org/gene/188937:MA_RS07675 ^@ http://purl.uniprot.org/uniprot/Q8TQR1 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/188937:MA_RS00330 ^@ http://purl.uniprot.org/uniprot/Q8TUK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/188937:MA_RS04565 ^@ http://purl.uniprot.org/uniprot/Q8TSC1 ^@ Similarity ^@ Belongs to the Mg-chelatase subunits D/I family. http://togogenome.org/gene/188937:MA_RS06060 ^@ http://purl.uniprot.org/uniprot/Q8TRL1 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the SMC family. RAD50 subfamily.|||Binds 1 zinc ion per homodimer.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.|||The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer. http://togogenome.org/gene/188937:MA_RS02070 ^@ http://purl.uniprot.org/uniprot/Q8TTN3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS21680 ^@ http://purl.uniprot.org/uniprot/Q8TIJ4 ^@ Function|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/188937:MA_RS00585 ^@ http://purl.uniprot.org/uniprot/Q8TUF5 ^@ Similarity ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. http://togogenome.org/gene/188937:MA_RS07110 ^@ http://purl.uniprot.org/uniprot/Q8TR15 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/188937:MA_RS08730 ^@ http://purl.uniprot.org/uniprot/Q8TQ68 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/188937:MA_RS17110 ^@ http://purl.uniprot.org/uniprot/Q8TKW5 ^@ Activity Regulation|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer. http://togogenome.org/gene/188937:MA_RS20435 ^@ http://purl.uniprot.org/uniprot/Q8TJ74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS19555 ^@ http://purl.uniprot.org/uniprot/Q8TJM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/188937:MA_RS20540 ^@ http://purl.uniprot.org/uniprot/Q8TJ53 ^@ Similarity ^@ Belongs to the UPF0166 family. http://togogenome.org/gene/188937:MA_RS07915 ^@ http://purl.uniprot.org/uniprot/Q8TQL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/188937:MA_RS04765 ^@ http://purl.uniprot.org/uniprot/P58862 ^@ Similarity ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/188937:MA_RS15965 ^@ http://purl.uniprot.org/uniprot/Q8TLI5 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/188937:MA_RS18725 ^@ http://purl.uniprot.org/uniprot/Q8TK35 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/188937:MA_RS18395 ^@ http://purl.uniprot.org/uniprot/Q8TK94 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/188937:MA_RS04640 ^@ http://purl.uniprot.org/uniprot/Q8TSA7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/188937:MA_RS04275 ^@ http://purl.uniprot.org/uniprot/Q8TSH5 ^@ Similarity ^@ Belongs to the archaeal-type GPI family. http://togogenome.org/gene/188937:MA_RS05715 ^@ http://purl.uniprot.org/uniprot/Q8TRS3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.|||Cytoplasm|||Monomer. http://togogenome.org/gene/188937:MA_RS09225 ^@ http://purl.uniprot.org/uniprot/Q8TPX8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/188937:MA_RS02820 ^@ http://purl.uniprot.org/uniprot/Q8TTA0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.|||Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.|||Monomer and homodimer. http://togogenome.org/gene/188937:MA_RS01485 ^@ http://purl.uniprot.org/uniprot/Q8TTZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/188937:MA_RS14475 ^@ http://purl.uniprot.org/uniprot/Q8TMA3 ^@ Similarity ^@ Belongs to the UPF0677 family. http://togogenome.org/gene/188937:MA_RS21215 ^@ http://purl.uniprot.org/uniprot/Q8TIS6 ^@ Similarity ^@ Belongs to the DNA photolyase class-2 family. http://togogenome.org/gene/188937:MA_RS09095 ^@ http://purl.uniprot.org/uniprot/Q8TQ00 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS00030 ^@ http://purl.uniprot.org/uniprot/Q8TUQ8 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/188937:MA_RS06725 ^@ http://purl.uniprot.org/uniprot/Q8TR85 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the HepT RNase toxin family.|||Homodimer, probably forms a complex with cognate antitoxin MA_1295.|||Modified by cognate antitoxin MA_1295; probably at least 2 successive AMPylation events occur on Tyr-82.|||Probable toxic component of a putative type VII toxin-antitoxin (TA) system, probably an RNase. Probably neutralized by cognate antitoxin MA_1295. Neutralization may be due to AMPylation by MA_1295. http://togogenome.org/gene/188937:MA_RS15810 ^@ http://purl.uniprot.org/uniprot/Q8TLL6 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/188937:MA_RS10210 ^@ http://purl.uniprot.org/uniprot/Q8TPF4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/188937:MA_RS04390 ^@ http://purl.uniprot.org/uniprot/Q8TSF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/188937:MA_RS03665 ^@ http://purl.uniprot.org/uniprot/Q8TSU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS00935 ^@ http://purl.uniprot.org/uniprot/Q8TUA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS05040 ^@ http://purl.uniprot.org/uniprot/Q8TS38 ^@ Function|||Similarity ^@ Belongs to the deoxyhypusine synthase family.|||Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. http://togogenome.org/gene/188937:MA_RS17325 ^@ http://purl.uniprot.org/uniprot/Q8TKS9 ^@ Similarity ^@ Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. http://togogenome.org/gene/188937:MA_RS22575 ^@ http://purl.uniprot.org/uniprot/Q8TI34 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGMT family.|||Cytoplasm|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.|||This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. http://togogenome.org/gene/188937:MA_RS17365 ^@ http://purl.uniprot.org/uniprot/Q8TKS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/188937:MA_RS05750 ^@ http://purl.uniprot.org/uniprot/Q8TRR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 2 subfamily.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS05305 ^@ http://purl.uniprot.org/uniprot/Q8TRZ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CdhB family.|||Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).|||Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation. http://togogenome.org/gene/188937:MA_RS21405 ^@ http://purl.uniprot.org/uniprot/Q9HH99 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm|||Mutants are auxotrophic for proline. http://togogenome.org/gene/188937:MA_RS05470 ^@ http://purl.uniprot.org/uniprot/Q8TRW8 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/188937:MA_RS07125 ^@ http://purl.uniprot.org/uniprot/Q8TR12 ^@ Similarity ^@ Belongs to the UPF0212 family. http://togogenome.org/gene/188937:MA_RS19140 ^@ http://purl.uniprot.org/uniprot/Q8TJV5 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/188937:MA_RS20990 ^@ http://purl.uniprot.org/uniprot/Q8TIW8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS12535 ^@ http://purl.uniprot.org/uniprot/Q8TN78 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/188937:MA_RS08905 ^@ http://purl.uniprot.org/uniprot/Q8TQ37 ^@ Similarity ^@ Belongs to the UPF0280 family. http://togogenome.org/gene/188937:MA_RS09970 ^@ http://purl.uniprot.org/uniprot/Q8TPJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/188937:MA_RS03175 ^@ http://purl.uniprot.org/uniprot/Q8TT35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/188937:MA_RS06445 ^@ http://purl.uniprot.org/uniprot/Q8TRD9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the FwdB family.|||Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.|||This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG. http://togogenome.org/gene/188937:MA_RS21910 ^@ http://purl.uniprot.org/uniprot/Q8TIF5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer. http://togogenome.org/gene/188937:MA_RS06520 ^@ http://purl.uniprot.org/uniprot/Q8TRC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS03475 ^@ http://purl.uniprot.org/uniprot/Q8TSY2 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RnfG family.|||Cell membrane|||Deletion of the rnf operon abolishes growth on acetate and ferredoxin:heterodisulfide oxidoreductase-coupled Na(+) transport.|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Catalyzes Na(+) transport, most probably coupled to electron transfer from reduced ferredoxin to methanophenazine and heterodisulfide reductase. Involved in heterodisulfide reduction during methanogenesis from acetate.|||The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/188937:MA_RS04625 ^@ http://purl.uniprot.org/uniprot/Q8TSB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/188937:MA_RS12635 ^@ http://purl.uniprot.org/uniprot/Q8TN60 ^@ Similarity ^@ Belongs to the ATPase gamma chain family. http://togogenome.org/gene/188937:MA_RS21355 ^@ http://purl.uniprot.org/uniprot/Q8TIQ0 ^@ Similarity|||Subunit ^@ Belongs to the HTP reductase family.|||Homodimer. http://togogenome.org/gene/188937:MA_RS02250 ^@ http://purl.uniprot.org/uniprot/Q8TTK2 ^@ Similarity ^@ Belongs to the LarC family. http://togogenome.org/gene/188937:MA_RS23855 ^@ http://purl.uniprot.org/uniprot/Q8THE2 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/188937:MA_RS10195 ^@ http://purl.uniprot.org/uniprot/Q8TPF7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/188937:MA_RS21470 ^@ http://purl.uniprot.org/uniprot/Q8TIN0 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/188937:MA_RS23680 ^@ http://purl.uniprot.org/uniprot/Q8THH5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane http://togogenome.org/gene/188937:MA_RS15065 ^@ http://purl.uniprot.org/uniprot/Q8TM00 ^@ Function|||Similarity ^@ Belongs to the ferredoxin thioredoxin reductase beta subunit family.|||Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin. http://togogenome.org/gene/188937:MA_RS10165 ^@ http://purl.uniprot.org/uniprot/Q8TPG4 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/188937:MA_RS00725 ^@ http://purl.uniprot.org/uniprot/Q8TUD0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecF subfamily.|||Cell membrane|||Involved in protein export.|||Membrane|||Part of the protein translocation apparatus. Forms a complex with SecD. http://togogenome.org/gene/188937:MA_RS02570 ^@ http://purl.uniprot.org/uniprot/Q8TTE4 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. http://togogenome.org/gene/188937:MA_RS06420 ^@ http://purl.uniprot.org/uniprot/Q8TRE5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS22610 ^@ http://purl.uniprot.org/uniprot/Q8TI28 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. http://togogenome.org/gene/188937:MA_RS16420 ^@ http://purl.uniprot.org/uniprot/Q8TLA0 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/188937:MA_RS07575 ^@ http://purl.uniprot.org/uniprot/Q8TQT0 ^@ Similarity ^@ Belongs to the PspA/IM30 family. http://togogenome.org/gene/188937:MA_RS21475 ^@ http://purl.uniprot.org/uniprot/Q8TIM9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||May be involved in maturation of the 30S ribosomal subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/188937:MA_RS16585 ^@ http://purl.uniprot.org/uniprot/Q8TL67 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS00730 ^@ http://purl.uniprot.org/uniprot/Q8TUC9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell membrane|||Involved in protein export.|||Membrane|||Part of the protein translocation apparatus. Forms a complex with SecF. http://togogenome.org/gene/188937:MA_RS04305 ^@ http://purl.uniprot.org/uniprot/Q8TSH0 ^@ Cofactor|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/188937:MA_RS16435 ^@ http://purl.uniprot.org/uniprot/Q8TL97 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS20565 ^@ http://purl.uniprot.org/uniprot/Q8TJ47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS16205 ^@ http://purl.uniprot.org/uniprot/Q8TLD9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS24325 ^@ http://purl.uniprot.org/uniprot/Q8TU85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the kinesin light chain family.|||cytoskeleton http://togogenome.org/gene/188937:MA_RS21455 ^@ http://purl.uniprot.org/uniprot/Q8TIN4 ^@ Function|||Similarity ^@ Belongs to the eIF-6 family.|||Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. http://togogenome.org/gene/188937:MA_RS23970 ^@ http://purl.uniprot.org/uniprot/Q8THC4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type-I 3-dehydroquinase family.|||Homodimer.|||Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. http://togogenome.org/gene/188937:MA_RS15570 ^@ http://purl.uniprot.org/uniprot/P58868 ^@ Function|||Similarity|||Subunit ^@ Acts as a methyl group carrier between MtmB and MtbA.|||Belongs to the methylamine corrinoid protein family.|||Can form a complex with MtmB. http://togogenome.org/gene/188937:MA_RS05825 ^@ http://purl.uniprot.org/uniprot/Q8TRQ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS01185 ^@ http://purl.uniprot.org/uniprot/Q8TU54 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FdhD family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Required for formate dehydrogenase (FDH) activity. http://togogenome.org/gene/188937:MA_RS05690 ^@ http://purl.uniprot.org/uniprot/Q8TRS8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/188937:MA_RS23935 ^@ http://purl.uniprot.org/uniprot/Q8THD0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/188937:MA_RS02880 ^@ http://purl.uniprot.org/uniprot/Q8TT89 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DHBP synthase family.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Homodimer. http://togogenome.org/gene/188937:MA_RS22005 ^@ http://purl.uniprot.org/uniprot/Q8TID9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/188937:MA_RS03400 ^@ http://purl.uniprot.org/uniprot/Q8TSZ7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/188937:MA_RS07965 ^@ http://purl.uniprot.org/uniprot/Q8TH29 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/188937:MA_RS24005 ^@ http://purl.uniprot.org/uniprot/Q8THB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/188937:MA_RS05600 ^@ http://purl.uniprot.org/uniprot/Q8TRU6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/188937:MA_RS03030 ^@ http://purl.uniprot.org/uniprot/Q8TT60 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/188937:MA_RS00985 ^@ http://purl.uniprot.org/uniprot/Q8TU91 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/188937:MA_RS19610 ^@ http://purl.uniprot.org/uniprot/Q8TJL8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS21400 ^@ http://purl.uniprot.org/uniprot/Q9HHA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate 5-kinase family.|||Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS15690 ^@ http://purl.uniprot.org/uniprot/Q8TLP2 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/188937:MA_RS01465 ^@ http://purl.uniprot.org/uniprot/Q8TTZ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrE family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/188937:MA_RS07515 ^@ http://purl.uniprot.org/uniprot/Q8TQU1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. TrmY family.|||Cytoplasm|||Homodimer.|||Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs. http://togogenome.org/gene/188937:MA_RS22015 ^@ http://purl.uniprot.org/uniprot/Q8TID7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamine synthetase family.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS08365 ^@ http://purl.uniprot.org/uniprot/Q8TQD4 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. Does not catalyze the conversion of O-acetyl-L-homoserine into threonine.|||Homotrimer.|||The N-terminal 41 amino acids are required for activity. http://togogenome.org/gene/188937:MA_RS23690 ^@ http://purl.uniprot.org/uniprot/Q8THH3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Monomer. http://togogenome.org/gene/188937:MA_RS23835 ^@ http://purl.uniprot.org/uniprot/Q8THE5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS01950 ^@ http://purl.uniprot.org/uniprot/Q8TTQ4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP. http://togogenome.org/gene/188937:MA_RS23955 ^@ http://purl.uniprot.org/uniprot/Q8THC7 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/188937:MA_RS21805 ^@ http://purl.uniprot.org/uniprot/Q8TIH1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the FwdB family.|||Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.|||This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG. http://togogenome.org/gene/188937:MA_RS08235 ^@ http://purl.uniprot.org/uniprot/Q8TQG0 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/188937:MA_RS21335 ^@ http://purl.uniprot.org/uniprot/Q8TIQ4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.|||Cell membrane|||Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function. http://togogenome.org/gene/188937:MA_RS07635 ^@ http://purl.uniprot.org/uniprot/Q8TQR9 ^@ Function|||Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family.|||Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. http://togogenome.org/gene/188937:MA_RS10730 ^@ http://purl.uniprot.org/uniprot/Q8TP54 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). http://togogenome.org/gene/188937:MA_RS19180 ^@ http://purl.uniprot.org/uniprot/Q8TJU7 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/188937:MA_RS15370 ^@ http://purl.uniprot.org/uniprot/Q8TLU2 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Potential transporter for phosphate. http://togogenome.org/gene/188937:MA_RS00685 ^@ http://purl.uniprot.org/uniprot/Q8TUD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/188937:MA_RS10005 ^@ http://purl.uniprot.org/uniprot/Q8TPJ2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/188937:MA_RS05155 ^@ http://purl.uniprot.org/uniprot/Q8TS20 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS17375 ^@ http://purl.uniprot.org/uniprot/Q8TH54 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/188937:MA_RS18005 ^@ http://purl.uniprot.org/uniprot/Q8TKF9 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/188937:MA_RS11800 ^@ http://purl.uniprot.org/uniprot/Q8TNL0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS17450 ^@ http://purl.uniprot.org/uniprot/Q8TKQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. http://togogenome.org/gene/188937:MA_RS00990 ^@ http://purl.uniprot.org/uniprot/Q8TU90 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/188937:MA_RS10415 ^@ http://purl.uniprot.org/uniprot/Q8TPB3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/188937:MA_RS13050 ^@ http://purl.uniprot.org/uniprot/Q8TMY4 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/188937:MA_RS19125 ^@ http://purl.uniprot.org/uniprot/Q8TJV8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/188937:MA_RS00010 ^@ http://purl.uniprot.org/uniprot/Q8TUR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/188937:MA_RS20155 ^@ http://purl.uniprot.org/uniprot/Q8TJC2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CdhD family.|||Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8) (Potential).|||Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex (By similarity). http://togogenome.org/gene/188937:MA_RS07685 ^@ http://purl.uniprot.org/uniprot/Q8TQQ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS13260 ^@ http://purl.uniprot.org/uniprot/Q8TMV1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/188937:MA_RS00170 ^@ http://purl.uniprot.org/uniprot/Q8TUN3 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/188937:MA_RS11125 ^@ http://purl.uniprot.org/uniprot/Q8TNY5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/188937:MA_RS05325 ^@ http://purl.uniprot.org/uniprot/P58837 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/188937:MA_RS00610 ^@ http://purl.uniprot.org/uniprot/Q8TUF0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal dihydroneopterin aldolase family.|||Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).|||Homotetramer. http://togogenome.org/gene/188937:MA_RS20350 ^@ http://purl.uniprot.org/uniprot/Q8TJ89 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NifD/NifK/NifE/NifN family.|||Binds 1 [8Fe-7S] cluster per heterodimer.|||Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).|||This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation. http://togogenome.org/gene/188937:MA_RS14645 ^@ http://purl.uniprot.org/uniprot/Q8TH39 ^@ Similarity ^@ Belongs to the bacterial reverse transcriptase family. http://togogenome.org/gene/188937:MA_RS22805 ^@ http://purl.uniprot.org/uniprot/Q8THZ8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/188937:MA_RS03245 ^@ http://purl.uniprot.org/uniprot/Q8TT22 ^@ Subcellular Location Annotation ^@ Membrane