http://togogenome.org/gene/2027290:CYG50_RS11400 ^@ http://purl.uniprot.org/uniprot/A0A345LSC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 3 family.|||Cell membrane|||NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/2027290:CYG50_RS04730 ^@ http://purl.uniprot.org/uniprot/A0A345LVS3 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS1 family.|||Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. http://togogenome.org/gene/2027290:CYG50_RS20285 ^@ http://purl.uniprot.org/uniprot/A0A345LYT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FliQ/MopD/SpaQ family.|||Cell membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS19760 ^@ http://purl.uniprot.org/uniprot/A0A345LZ21 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2027290:CYG50_RS01755 ^@ http://purl.uniprot.org/uniprot/A0A345LXC8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.|||Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.|||Cytoplasm|||Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).|||The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.|||The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1. http://togogenome.org/gene/2027290:CYG50_RS06395 ^@ http://purl.uniprot.org/uniprot/A0A345LUX1 ^@ Similarity ^@ Belongs to the phage portal family. PBSX subfamily. http://togogenome.org/gene/2027290:CYG50_RS04045 ^@ http://purl.uniprot.org/uniprot/A0A345LW57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gluconeogenesis factor family.|||Cytoplasm|||Required for morphogenesis under gluconeogenic growth conditions. http://togogenome.org/gene/2027290:CYG50_RS18155 ^@ http://purl.uniprot.org/uniprot/A0A345LZV7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/2027290:CYG50_RS22325 ^@ http://purl.uniprot.org/uniprot/A0A345LXQ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.|||The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. http://togogenome.org/gene/2027290:CYG50_RS18100 ^@ http://purl.uniprot.org/uniprot/A0A345LZW8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/2027290:CYG50_RS17440 ^@ http://purl.uniprot.org/uniprot/A0A345M077 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ArgR family.|||Cytoplasm|||Regulates arginine biosynthesis genes. http://togogenome.org/gene/2027290:CYG50_RS15960 ^@ http://purl.uniprot.org/uniprot/A0A345M103 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS16080 ^@ http://purl.uniprot.org/uniprot/A0A345M0X9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FrdC family.|||Cell membrane|||Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).|||Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth. Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones. http://togogenome.org/gene/2027290:CYG50_RS12045 ^@ http://purl.uniprot.org/uniprot/A0A345LS11 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.|||Cytoplasm|||Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.|||Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. http://togogenome.org/gene/2027290:CYG50_RS18150 ^@ http://purl.uniprot.org/uniprot/A0A345LZV8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/2027290:CYG50_RS04085 ^@ http://purl.uniprot.org/uniprot/A0A345LW49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS17135 ^@ http://purl.uniprot.org/uniprot/A0A8I2AMT5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RraB family.|||Cytoplasm|||Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.|||Interacts with the C-terminal region of Rne.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/2027290:CYG50_RS00635 ^@ http://purl.uniprot.org/uniprot/A0A345LR93 ^@ Function ^@ TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites. http://togogenome.org/gene/2027290:CYG50_RS17330 ^@ http://purl.uniprot.org/uniprot/A0A345M096 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/2027290:CYG50_RS19835 ^@ http://purl.uniprot.org/uniprot/A0A345LZ07 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||Monomer. http://togogenome.org/gene/2027290:CYG50_RS00935 ^@ http://purl.uniprot.org/uniprot/A0A345LRE4 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/2027290:CYG50_RS02085 ^@ http://purl.uniprot.org/uniprot/A0A345LX61 ^@ Similarity ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. http://togogenome.org/gene/2027290:CYG50_RS18110 ^@ http://purl.uniprot.org/uniprot/A0A345LZW6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/2027290:CYG50_RS02260 ^@ http://purl.uniprot.org/uniprot/A0A345LX25 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.|||Cell membrane|||Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS14975 ^@ http://purl.uniprot.org/uniprot/A0A345M1J1 ^@ Function|||Similarity ^@ Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.|||Belongs to the Nudix hydrolase family. RppH subfamily. http://togogenome.org/gene/2027290:CYG50_RS12020 ^@ http://purl.uniprot.org/uniprot/A0A345LS16 ^@ Similarity ^@ Belongs to the adrenodoxin/putidaredoxin family. http://togogenome.org/gene/2027290:CYG50_RS11370 ^@ http://purl.uniprot.org/uniprot/A0A345LSC9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 1 family.|||Cell membrane|||Membrane|||NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. http://togogenome.org/gene/2027290:CYG50_RS11500 ^@ http://purl.uniprot.org/uniprot/A0A345LSA5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2027290:CYG50_RS14860 ^@ http://purl.uniprot.org/uniprot/A0A345M1L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0382 family.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS20570 ^@ http://purl.uniprot.org/uniprot/A0A345LYM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GlpE family.|||Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.|||Cytoplasm http://togogenome.org/gene/2027290:CYG50_RS04905 ^@ http://purl.uniprot.org/uniprot/A0A345LVN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GhoT/OrtT toxin family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS18195 ^@ http://purl.uniprot.org/uniprot/A0A345LZU9 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/2027290:CYG50_RS01900 ^@ http://purl.uniprot.org/uniprot/A0A345LXA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS14745 ^@ http://purl.uniprot.org/uniprot/A0A345M1N2 ^@ Similarity ^@ Belongs to the skp family. http://togogenome.org/gene/2027290:CYG50_RS11380 ^@ http://purl.uniprot.org/uniprot/A0A345LSC8 ^@ Function|||Similarity ^@ Belongs to the complex I 51 kDa subunit family.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. http://togogenome.org/gene/2027290:CYG50_RS14170 ^@ http://purl.uniprot.org/uniprot/A0A345M1Y6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DksA family.|||Cytoplasm|||Interacts directly with the RNA polymerase.|||Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. http://togogenome.org/gene/2027290:CYG50_RS06295 ^@ http://purl.uniprot.org/uniprot/A0A345LUY9 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/2027290:CYG50_RS04295 ^@ http://purl.uniprot.org/uniprot/A0A345LW09 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Catalyzes the deamination of dCTP to dUTP.|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2027290:CYG50_RS12955 ^@ http://purl.uniprot.org/uniprot/A0A345M2L3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.|||Cell membrane|||Self-interacts. Interacts with FtsZ. http://togogenome.org/gene/2027290:CYG50_RS17565 ^@ http://purl.uniprot.org/uniprot/A0A345M055 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with bS18 to 16S ribosomal RNA. http://togogenome.org/gene/2027290:CYG50_RS16500 ^@ http://purl.uniprot.org/uniprot/A0A345M0P9 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS00300 ^@ http://purl.uniprot.org/uniprot/A0A345LR33 ^@ Similarity ^@ Belongs to the site-specific recombinase resolvase family. http://togogenome.org/gene/2027290:CYG50_RS09325 ^@ http://purl.uniprot.org/uniprot/A0A345LTF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS14640 ^@ http://purl.uniprot.org/uniprot/A0A345M1Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nlpA lipoprotein family.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS04180 ^@ http://purl.uniprot.org/uniprot/A0A345LW31 ^@ Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase I family.|||Homopolymer.|||Toroid-shaped homodecamer, composed of two pentamers of five dimers. http://togogenome.org/gene/2027290:CYG50_RS05415 ^@ http://purl.uniprot.org/uniprot/A0A345LVF3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family.|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each. http://togogenome.org/gene/2027290:CYG50_RS21200 ^@ http://purl.uniprot.org/uniprot/A0A345LYB2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/2027290:CYG50_RS21195 ^@ http://purl.uniprot.org/uniprot/A0A345LYB3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/2027290:CYG50_RS00645 ^@ http://purl.uniprot.org/uniprot/A0A345LR95 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Bcr/CmlA family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS03830 ^@ http://purl.uniprot.org/uniprot/A0A345LW98 ^@ Cofactor|||Similarity ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/2027290:CYG50_RS06005 ^@ http://purl.uniprot.org/uniprot/A0A345LV45 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2027290:CYG50_RS20575 ^@ http://purl.uniprot.org/uniprot/A0A345LYM8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NfuA family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is presumably bound at the interface of two monomers.|||Homodimer.|||Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. http://togogenome.org/gene/2027290:CYG50_RS01300 ^@ http://purl.uniprot.org/uniprot/A0A345LRL1 ^@ Similarity ^@ Belongs to the aminoglycoside phosphotransferase family. http://togogenome.org/gene/2027290:CYG50_RS18175 ^@ http://purl.uniprot.org/uniprot/A0A345LZV3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/2027290:CYG50_RS15600 ^@ http://purl.uniprot.org/uniprot/A0A345M172 ^@ Similarity ^@ Belongs to the GST superfamily. HSP26 family. http://togogenome.org/gene/2027290:CYG50_RS11990 ^@ http://purl.uniprot.org/uniprot/A0A345LS21 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NDK family.|||Cytoplasm|||Homotetramer.|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/2027290:CYG50_RS12950 ^@ http://purl.uniprot.org/uniprot/A0A345M2L4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/2027290:CYG50_RS06290 ^@ http://purl.uniprot.org/uniprot/A0A345LUZ0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/2027290:CYG50_RS19910 ^@ http://purl.uniprot.org/uniprot/A0A345LYZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal stress protein A family.|||Cytoplasm http://togogenome.org/gene/2027290:CYG50_RS01265 ^@ http://purl.uniprot.org/uniprot/A0A345LRK5 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/2027290:CYG50_RS02115 ^@ http://purl.uniprot.org/uniprot/A0A345LX55 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecF subfamily.|||Cell membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/2027290:CYG50_RS19380 ^@ http://purl.uniprot.org/uniprot/A0A345LZ89 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2027290:CYG50_RS18210 ^@ http://purl.uniprot.org/uniprot/A0A345LZU6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2027290:CYG50_RS05530 ^@ http://purl.uniprot.org/uniprot/A0A345LVC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliN/MopA/SpaO family.|||Cell membrane|||FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS09590 ^@ http://purl.uniprot.org/uniprot/A0A345LTA4 ^@ Similarity ^@ Belongs to the UPF0181 family. http://togogenome.org/gene/2027290:CYG50_RS02010 ^@ http://purl.uniprot.org/uniprot/A0A345LX79 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/2027290:CYG50_RS15710 ^@ http://purl.uniprot.org/uniprot/A0A345M150 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RapZ-like family. RapZ subfamily.|||Homotrimer.|||Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS. http://togogenome.org/gene/2027290:CYG50_RS01100 ^@ http://purl.uniprot.org/uniprot/A0A345LRH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thioredoxin family. DsbC subfamily.|||Periplasm|||Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. http://togogenome.org/gene/2027290:CYG50_RS18115 ^@ http://purl.uniprot.org/uniprot/A0A345LZW5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/2027290:CYG50_RS01350 ^@ http://purl.uniprot.org/uniprot/A0A345LRA2 ^@ Function ^@ Involved in the transposition of the insertion sequence. http://togogenome.org/gene/2027290:CYG50_RS21465 ^@ http://purl.uniprot.org/uniprot/A0A345LY60 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/2027290:CYG50_RS00385 ^@ http://purl.uniprot.org/uniprot/A0A345LR49 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2027290:CYG50_RS11385 ^@ http://purl.uniprot.org/uniprot/A0A345LSC7 ^@ Similarity ^@ Belongs to the complex I 24 kDa subunit family. http://togogenome.org/gene/2027290:CYG50_RS10695 ^@ http://purl.uniprot.org/uniprot/A0A345LSQ3 ^@ Cofactor ^@ Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/2027290:CYG50_RS18200 ^@ http://purl.uniprot.org/uniprot/A0A345LZU8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/2027290:CYG50_RS14340 ^@ http://purl.uniprot.org/uniprot/A0A345M1V5 ^@ Similarity ^@ Belongs to the UPF0423 family. http://togogenome.org/gene/2027290:CYG50_RS14145 ^@ http://purl.uniprot.org/uniprot/A0A345M1Z1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HesB/IscA family.|||Binds 1 iron-sulfur cluster per subunit.|||Homodimer.|||Required for insertion of 4Fe-4S clusters for at least IspG. http://togogenome.org/gene/2027290:CYG50_RS15605 ^@ http://purl.uniprot.org/uniprot/A0A345M171 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/2027290:CYG50_RS15620 ^@ http://purl.uniprot.org/uniprot/A0A345M168 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZapG family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS16165 ^@ http://purl.uniprot.org/uniprot/A0A345M0W2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/2027290:CYG50_RS01505 ^@ http://purl.uniprot.org/uniprot/A0A345LXH7 ^@ Similarity ^@ Belongs to the CbbQ/NirQ/NorQ/GpvN family. http://togogenome.org/gene/2027290:CYG50_RS18170 ^@ http://purl.uniprot.org/uniprot/A0A345LZV4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/2027290:CYG50_RS01295 ^@ http://purl.uniprot.org/uniprot/A0A345LRL0 ^@ Function|||Similarity ^@ Belongs to the DHPS family.|||Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives. http://togogenome.org/gene/2027290:CYG50_RS03560 ^@ http://purl.uniprot.org/uniprot/A0A345LWE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase RlmH family.|||Cytoplasm|||Homodimer.|||Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. http://togogenome.org/gene/2027290:CYG50_RS07220 ^@ http://purl.uniprot.org/uniprot/A0A345LUH8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/2027290:CYG50_RS04125 ^@ http://purl.uniprot.org/uniprot/A0A345LW41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0410 family.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS05595 ^@ http://purl.uniprot.org/uniprot/A0A345LVB7 ^@ Similarity ^@ Belongs to the EcnA/EcnB lipoprotein family. http://togogenome.org/gene/2027290:CYG50_RS01490 ^@ http://purl.uniprot.org/uniprot/A0A345LXI0 ^@ Caution|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2027290:CYG50_RS08065 ^@ http://purl.uniprot.org/uniprot/A0A345LU28 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Cytoplasm|||Homodimer.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/2027290:CYG50_RS00670 ^@ http://purl.uniprot.org/uniprot/A0A345LRA0 ^@ Function|||Similarity ^@ Belongs to the dihydrofolate reductase family.|||Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. http://togogenome.org/gene/2027290:CYG50_RS04960 ^@ http://purl.uniprot.org/uniprot/A0A345LVN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dsrC/tusE family.|||Cytoplasm|||Interacts with the TusBCD complex. Interacts with MnmA.|||Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Could accept sulfur from TusD. http://togogenome.org/gene/2027290:CYG50_RS11520 ^@ http://purl.uniprot.org/uniprot/A0A345M2S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DedA family.|||Cell membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS04165 ^@ http://purl.uniprot.org/uniprot/A0A345M307 ^@ Similarity ^@ Belongs to the YjdM family. http://togogenome.org/gene/2027290:CYG50_RS14735 ^@ http://purl.uniprot.org/uniprot/A0A345M1N4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thioester dehydratase family. FabZ subfamily.|||Cytoplasm|||Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. http://togogenome.org/gene/2027290:CYG50_RS12015 ^@ http://purl.uniprot.org/uniprot/A0A345LS17 ^@ Function|||Similarity ^@ Belongs to the IscX family.|||May function as iron donor in the assembly of iron-sulfur clusters. http://togogenome.org/gene/2027290:CYG50_RS00595 ^@ http://purl.uniprot.org/uniprot/A0A345LR85 ^@ Similarity ^@ Belongs to the site-specific recombinase resolvase family. http://togogenome.org/gene/2027290:CYG50_RS11625 ^@ http://purl.uniprot.org/uniprot/A0A345LS82 ^@ Function|||Similarity ^@ Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.|||Methylates ribosomal protein uL3 on a specific glutamine residue. http://togogenome.org/gene/2027290:CYG50_RS03815 ^@ http://purl.uniprot.org/uniprot/A0A345LWA1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b560 family.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH).|||Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.|||The heme is bound between the two transmembrane subunits. http://togogenome.org/gene/2027290:CYG50_RS06185 ^@ http://purl.uniprot.org/uniprot/A0A345LV10 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2027290:CYG50_RS17260 ^@ http://purl.uniprot.org/uniprot/A0A345M0A6 ^@ Similarity ^@ Belongs to the RelB/DinJ antitoxin family. http://togogenome.org/gene/2027290:CYG50_RS16285 ^@ http://purl.uniprot.org/uniprot/A0A345M0T9 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial microcompartment|||Belongs to the bacterial microcompartments protein family. http://togogenome.org/gene/2027290:CYG50_RS12750 ^@ http://purl.uniprot.org/uniprot/A0A345M2Q0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/2027290:CYG50_RS03880 ^@ http://purl.uniprot.org/uniprot/A0A345LW88 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ExbB/TolQ family.|||Cell inner membrane|||Membrane|||Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction.|||The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer. http://togogenome.org/gene/2027290:CYG50_RS19105 ^@ http://purl.uniprot.org/uniprot/A0A345LZE0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoid occlusion factor SlmA family.|||Homodimer. Interacts with FtsZ.|||Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.|||nucleoid http://togogenome.org/gene/2027290:CYG50_RS03810 ^@ http://purl.uniprot.org/uniprot/A0A345LWA2 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/2027290:CYG50_RS15610 ^@ http://purl.uniprot.org/uniprot/A0A345M170 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/2027290:CYG50_RS18090 ^@ http://purl.uniprot.org/uniprot/A0A345LZX0 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/2027290:CYG50_RS19530 ^@ http://purl.uniprot.org/uniprot/A0A345LZ59 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/2027290:CYG50_RS02280 ^@ http://purl.uniprot.org/uniprot/A0A345LX21 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Cell membrane|||Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.|||Heterooctamer of two A chains, two B chains, two C chains and two D chains.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS06080 ^@ http://purl.uniprot.org/uniprot/A0A345LV30 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/2027290:CYG50_RS02365 ^@ http://purl.uniprot.org/uniprot/A0A345LX04 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/2027290:CYG50_RS14040 ^@ http://purl.uniprot.org/uniprot/A0A345M211 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YbaB/EbfC family.|||Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.|||Homodimer.|||nucleoid http://togogenome.org/gene/2027290:CYG50_RS22660 ^@ http://purl.uniprot.org/uniprot/A0A345LXK4 ^@ Function|||Similarity ^@ Belongs to the dihydrofolate reductase family.|||Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. http://togogenome.org/gene/2027290:CYG50_RS20790 ^@ http://purl.uniprot.org/uniprot/A0A345LYI9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutamine synthetase family.|||Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.|||Cytoplasm|||Oligomer of 12 subunits arranged in the form of two hexagons. http://togogenome.org/gene/2027290:CYG50_RS17205 ^@ http://purl.uniprot.org/uniprot/A0A345M0B6 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/2027290:CYG50_RS22705 ^@ http://purl.uniprot.org/uniprot/A0A345LXJ7 ^@ Similarity ^@ Belongs to the class-A beta-lactamase family. http://togogenome.org/gene/2027290:CYG50_RS11235 ^@ http://purl.uniprot.org/uniprot/A0A345LSF6 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the RcsB family.|||Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions.|||Interacts with RcsD.|||Phosphorylated and activated by RcsD. http://togogenome.org/gene/2027290:CYG50_RS04560 ^@ http://purl.uniprot.org/uniprot/A0A345LVV6 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/2027290:CYG50_RS13355 ^@ http://purl.uniprot.org/uniprot/A0A345M2E0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NapF family.|||Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, before its export into the periplasm.|||Cytoplasm|||Interacts with the cytoplasmic NapA precursor. http://togogenome.org/gene/2027290:CYG50_RS17605 ^@ http://purl.uniprot.org/uniprot/A0A345M047 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/2027290:CYG50_RS18190 ^@ http://purl.uniprot.org/uniprot/A0A345LZV0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/2027290:CYG50_RS21600 ^@ http://purl.uniprot.org/uniprot/A0A345LY40 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase S24 family.|||Homodimer.|||Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. http://togogenome.org/gene/2027290:CYG50_RS18105 ^@ http://purl.uniprot.org/uniprot/A0A345LZW7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/2027290:CYG50_RS19560 ^@ http://purl.uniprot.org/uniprot/A0A345LZ53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS16230 ^@ http://purl.uniprot.org/uniprot/A0A345M0V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS12385 ^@ http://purl.uniprot.org/uniprot/A0A345LRU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/2027290:CYG50_RS04430 ^@ http://purl.uniprot.org/uniprot/A0A345LVY2 ^@ Similarity|||Subunit ^@ Belongs to the glutaredoxin family.|||Monomer. http://togogenome.org/gene/2027290:CYG50_RS11355 ^@ http://purl.uniprot.org/uniprot/A0A345LSD2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Cell membrane|||Membrane|||NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/2027290:CYG50_RS19455 ^@ http://purl.uniprot.org/uniprot/A0A345LZ73 ^@ Function|||Similarity ^@ Belongs to the dihydrofolate reductase family.|||Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. http://togogenome.org/gene/2027290:CYG50_RS18085 ^@ http://purl.uniprot.org/uniprot/A0A345LZX1 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/2027290:CYG50_RS02275 ^@ http://purl.uniprot.org/uniprot/A0A345LX22 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heme-copper respiratory oxidase family.|||Membrane|||The cytochrome bo(3) ubiquinol oxidase complex is a heterooctamer of two A chains, two B chains, two C chains and two D chains. http://togogenome.org/gene/2027290:CYG50_RS16280 ^@ http://purl.uniprot.org/uniprot/A0A345M0U0 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial microcompartment|||Belongs to the bacterial microcompartments protein family. http://togogenome.org/gene/2027290:CYG50_RS17360 ^@ http://purl.uniprot.org/uniprot/A0A345M093 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS11985 ^@ http://purl.uniprot.org/uniprot/A0A345M2S1 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RlmN family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.|||Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity. http://togogenome.org/gene/2027290:CYG50_RS15785 ^@ http://purl.uniprot.org/uniprot/A0A345M135 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MreD family.|||Cell inner membrane|||Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS18460 ^@ http://purl.uniprot.org/uniprot/A0A345LZQ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZapB family.|||Cytoplasm|||Homodimer. The ends of the coiled-coil dimer bind to each other, forming polymers. Interacts with FtsZ.|||Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. http://togogenome.org/gene/2027290:CYG50_RS01315 ^@ http://purl.uniprot.org/uniprot/A0A345LR86 ^@ Similarity ^@ Belongs to the class-A beta-lactamase family. http://togogenome.org/gene/2027290:CYG50_RS21310 ^@ http://purl.uniprot.org/uniprot/A0A345LY90 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2027290:CYG50_RS06855 ^@ http://purl.uniprot.org/uniprot/A0A345LUN7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2027290:CYG50_RS19750 ^@ http://purl.uniprot.org/uniprot/A0A345LZ23 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2027290:CYG50_RS03595 ^@ http://purl.uniprot.org/uniprot/A0A345LWD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS04765 ^@ http://purl.uniprot.org/uniprot/A0A345LVR6 ^@ Similarity ^@ Belongs to the UPF0434 family. http://togogenome.org/gene/2027290:CYG50_RS09440 ^@ http://purl.uniprot.org/uniprot/A0A345LTD0 ^@ Function|||Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. http://togogenome.org/gene/2027290:CYG50_RS19755 ^@ http://purl.uniprot.org/uniprot/A0A345LZ22 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/2027290:CYG50_RS09285 ^@ http://purl.uniprot.org/uniprot/A0A345LTF9 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/2027290:CYG50_RS18965 ^@ http://purl.uniprot.org/uniprot/A0A345LZG5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecB family.|||Cytoplasm|||Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.|||One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. http://togogenome.org/gene/2027290:CYG50_RS16695 ^@ http://purl.uniprot.org/uniprot/A0A345M0L1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2027290:CYG50_RS19565 ^@ http://purl.uniprot.org/uniprot/A0A345LZ52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Cell membrane|||Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS19315 ^@ http://purl.uniprot.org/uniprot/A0A345LZA2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.|||Cell membrane|||Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.|||Membrane|||Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. http://togogenome.org/gene/2027290:CYG50_RS16490 ^@ http://purl.uniprot.org/uniprot/A0A8I2AD47 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/2027290:CYG50_RS09625 ^@ http://purl.uniprot.org/uniprot/A0A345LT98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0266 family.|||Cell membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS12135 ^@ http://purl.uniprot.org/uniprot/A0A345LRZ4 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/2027290:CYG50_RS03845 ^@ http://purl.uniprot.org/uniprot/A0A345LW95 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/2027290:CYG50_RS15730 ^@ http://purl.uniprot.org/uniprot/A0A345M146 ^@ Similarity ^@ Belongs to the UPF0307 family. http://togogenome.org/gene/2027290:CYG50_RS15340 ^@ http://purl.uniprot.org/uniprot/A0A345M1C0 ^@ Similarity ^@ Belongs to the HupF/HypC family. http://togogenome.org/gene/2027290:CYG50_RS15175 ^@ http://purl.uniprot.org/uniprot/A0A345M1F3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/2027290:CYG50_RS01610 ^@ http://purl.uniprot.org/uniprot/A0A345LXF6 ^@ Function ^@ Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways. http://togogenome.org/gene/2027290:CYG50_RS15840 ^@ http://purl.uniprot.org/uniprot/A0A345M126 ^@ Function|||Similarity|||Subunit ^@ Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters.|||Belongs to the transcriptional regulatory Fis family.|||Homodimer. http://togogenome.org/gene/2027290:CYG50_RS18955 ^@ http://purl.uniprot.org/uniprot/A0A345LZG7 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/2027290:CYG50_RS04670 ^@ http://purl.uniprot.org/uniprot/A0A345LVT5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Fur family.|||Binds 1 Mn(2+) or Fe(2+) ion per subunit.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2027290:CYG50_RS06685 ^@ http://purl.uniprot.org/uniprot/A0A345LUR6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane.|||Belongs to the Lpp family.|||Cell outer membrane|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||cell wall http://togogenome.org/gene/2027290:CYG50_RS17630 ^@ http://purl.uniprot.org/uniprot/A0A345M042 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsaE family.|||Cytoplasm http://togogenome.org/gene/2027290:CYG50_RS13930 ^@ http://purl.uniprot.org/uniprot/A0A345M231 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/2027290:CYG50_RS02220 ^@ http://purl.uniprot.org/uniprot/A0A345LX33 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseB family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/2027290:CYG50_RS17390 ^@ http://purl.uniprot.org/uniprot/A0A345M087 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/2027290:CYG50_RS22280 ^@ http://purl.uniprot.org/uniprot/A0A345LXR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate.|||Cytoplasm http://togogenome.org/gene/2027290:CYG50_RS17345 ^@ http://purl.uniprot.org/uniprot/A0A345M376 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RimP family.|||Cytoplasm|||Required for maturation of 30S ribosomal subunits. http://togogenome.org/gene/2027290:CYG50_RS00345 ^@ http://purl.uniprot.org/uniprot/A0A345LXJ0 ^@ Function|||Similarity ^@ Belongs to the DHPS family.|||Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives. http://togogenome.org/gene/2027290:CYG50_RS18330 ^@ http://purl.uniprot.org/uniprot/A0A345LZT3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Homodimer.|||Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. http://togogenome.org/gene/2027290:CYG50_RS03900 ^@ http://purl.uniprot.org/uniprot/A0A345LW84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Pal lipoprotein family.|||Cell outer membrane|||Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.|||The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer. http://togogenome.org/gene/2027290:CYG50_RS16290 ^@ http://purl.uniprot.org/uniprot/A0A345M0T8 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial microcompartment|||Belongs to the bacterial microcompartments protein family. http://togogenome.org/gene/2027290:CYG50_RS06165 ^@ http://purl.uniprot.org/uniprot/A0A345LV13 ^@ Similarity ^@ Belongs to the UPF0339 family. Duplicated subfamily. http://togogenome.org/gene/2027290:CYG50_RS12595 ^@ http://purl.uniprot.org/uniprot/A0A345LRQ9 ^@ Similarity ^@ Belongs to the FrmR/RcnR family. http://togogenome.org/gene/2027290:CYG50_RS01345 ^@ http://purl.uniprot.org/uniprot/A0A345LRL9 ^@ Function|||Similarity ^@ Belongs to the antibiotic N-acetyltransferase family.|||Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin. http://togogenome.org/gene/2027290:CYG50_RS00295 ^@ http://purl.uniprot.org/uniprot/A0A345LR32 ^@ Similarity ^@ Belongs to the transposase 7 family. http://togogenome.org/gene/2027290:CYG50_RS19080 ^@ http://purl.uniprot.org/uniprot/A0A345LZE3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/2027290:CYG50_RS19770 ^@ http://purl.uniprot.org/uniprot/A0A345LZ19 ^@ Similarity ^@ Belongs to the transposase 7 family. http://togogenome.org/gene/2027290:CYG50_RS12795 ^@ http://purl.uniprot.org/uniprot/A0A345M2P2 ^@ Function|||Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate. http://togogenome.org/gene/2027290:CYG50_RS18125 ^@ http://purl.uniprot.org/uniprot/A0A345LZW3 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2027290:CYG50_RS06660 ^@ http://purl.uniprot.org/uniprot/A0A345LUS1 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/2027290:CYG50_RS00650 ^@ http://purl.uniprot.org/uniprot/A0A345LR96 ^@ Function|||Similarity ^@ Belongs to the DHPS family.|||Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives. http://togogenome.org/gene/2027290:CYG50_RS22655 ^@ http://purl.uniprot.org/uniprot/A0A345LXK5 ^@ Similarity ^@ Belongs to the class-D beta-lactamase family. http://togogenome.org/gene/2027290:CYG50_RS16075 ^@ http://purl.uniprot.org/uniprot/A0A345M0Y0 ^@ Cofactor|||Similarity ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/2027290:CYG50_RS04535 ^@ http://purl.uniprot.org/uniprot/A0A345LVW1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/2027290:CYG50_RS03325 ^@ http://purl.uniprot.org/uniprot/A0A345LWI3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/2027290:CYG50_RS15325 ^@ http://purl.uniprot.org/uniprot/A0A345M1C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.|||Cytoplasm|||Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.|||Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. http://togogenome.org/gene/2027290:CYG50_RS01935 ^@ http://purl.uniprot.org/uniprot/A0A345LX94 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/2027290:CYG50_RS14810 ^@ http://purl.uniprot.org/uniprot/A0A345M1M0 ^@ Similarity ^@ Belongs to the UPF0325 family. http://togogenome.org/gene/2027290:CYG50_RS15300 ^@ http://purl.uniprot.org/uniprot/A0A345M1C8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the urease gamma subunit family.|||Cytoplasm|||Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. http://togogenome.org/gene/2027290:CYG50_RS02250 ^@ http://purl.uniprot.org/uniprot/A0A345LX27 ^@ Similarity ^@ Belongs to the UPF0234 family. http://togogenome.org/gene/2027290:CYG50_RS21080 ^@ http://purl.uniprot.org/uniprot/A0A345LYD5 ^@ Similarity ^@ Belongs to the phosphoribulokinase family. http://togogenome.org/gene/2027290:CYG50_RS18550 ^@ http://purl.uniprot.org/uniprot/A0A345LZP4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/2027290:CYG50_RS18180 ^@ http://purl.uniprot.org/uniprot/A0A345LZV2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2027290:CYG50_RS01030 ^@ http://purl.uniprot.org/uniprot/A0A345LRG0 ^@ Caution|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2027290:CYG50_RS19915 ^@ http://purl.uniprot.org/uniprot/A0A345LYZ2 ^@ Function|||Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. http://togogenome.org/gene/2027290:CYG50_RS00335 ^@ http://purl.uniprot.org/uniprot/A0A345LR40 ^@ Similarity ^@ Belongs to the bacterial reverse transcriptase family. http://togogenome.org/gene/2027290:CYG50_RS00685 ^@ http://purl.uniprot.org/uniprot/A0A345LRA2 ^@ Function ^@ Involved in the transposition of the insertion sequence. http://togogenome.org/gene/2027290:CYG50_RS16270 ^@ http://purl.uniprot.org/uniprot/A0A345M0U2 ^@ Similarity ^@ Belongs to the CcmL/EutN family. http://togogenome.org/gene/2027290:CYG50_RS00630 ^@ http://purl.uniprot.org/uniprot/A0A345LR92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. TCR/Tet family.|||Membrane|||Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter. http://togogenome.org/gene/2027290:CYG50_RS06845 ^@ http://purl.uniprot.org/uniprot/A0A345LUN9 ^@ Similarity ^@ Belongs to the PspA/IM30 family. http://togogenome.org/gene/2027290:CYG50_RS01595 ^@ http://purl.uniprot.org/uniprot/A0A345LXF9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer.|||Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0). http://togogenome.org/gene/2027290:CYG50_RS11395 ^@ http://purl.uniprot.org/uniprot/A0A345LSC5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 20 kDa subunit family.|||Binds 1 [4Fe-4S] cluster.|||Cell membrane|||NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/2027290:CYG50_RS01575 ^@ http://purl.uniprot.org/uniprot/A0A345LXG3 ^@ Function ^@ Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site. http://togogenome.org/gene/2027290:CYG50_RS13330 ^@ http://purl.uniprot.org/uniprot/A0A345M2E5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NapB family.|||Binds 2 heme C groups per subunit.|||Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.|||Electron transfer subunit of the periplasmic nitrate reductase complex NapAB.|||Periplasm http://togogenome.org/gene/2027290:CYG50_RS18215 ^@ http://purl.uniprot.org/uniprot/A0A345LZU5 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||Methylated by PrmB.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/2027290:CYG50_RS16085 ^@ http://purl.uniprot.org/uniprot/A0A345M0X8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FrdD family.|||Cell membrane|||Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).|||Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth. Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones. http://togogenome.org/gene/2027290:CYG50_RS12040 ^@ http://purl.uniprot.org/uniprot/A0A345LS12 ^@ Function|||Similarity ^@ A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.|||Belongs to the NifU family. http://togogenome.org/gene/2027290:CYG50_RS18810 ^@ http://purl.uniprot.org/uniprot/A0A345LZJ3 ^@ Subcellular Location Annotation ^@ Cell inner membrane http://togogenome.org/gene/2027290:CYG50_RS06100 ^@ http://purl.uniprot.org/uniprot/A0A345LV26 ^@ Similarity ^@ Belongs to the SorC transcriptional regulatory family. http://togogenome.org/gene/2027290:CYG50_RS18440 ^@ http://purl.uniprot.org/uniprot/A0A345LZR2 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||Allosterically activated by HslU binding.|||Belongs to the peptidase T1B family. HslV subfamily.|||Cytoplasm|||Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. http://togogenome.org/gene/2027290:CYG50_RS09360 ^@ http://purl.uniprot.org/uniprot/A0A345LTE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone-like protein H-NS family.|||nucleoid http://togogenome.org/gene/2027290:CYG50_RS18205 ^@ http://purl.uniprot.org/uniprot/A0A345LZU7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/2027290:CYG50_RS02270 ^@ http://purl.uniprot.org/uniprot/A0A345LX23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Cell membrane|||Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.|||Heterooctamer of two A chains, two B chains, two C chains and two D chains.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS11365 ^@ http://purl.uniprot.org/uniprot/A0A345LSD0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 23 kDa subunit family.|||Binds 2 [4Fe-4S] clusters per subunit.|||Cell membrane|||NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/2027290:CYG50_RS15795 ^@ http://purl.uniprot.org/uniprot/A0A345M133 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers. http://togogenome.org/gene/2027290:CYG50_RS14780 ^@ http://purl.uniprot.org/uniprot/A0A345M1M6 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by GTP. Inhibited by UTP.|||Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2027290:CYG50_RS10865 ^@ http://purl.uniprot.org/uniprot/A0A345LSM1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/2027290:CYG50_RS02105 ^@ http://purl.uniprot.org/uniprot/A0A345LX57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YajC family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS01040 ^@ http://purl.uniprot.org/uniprot/A0A345LRG2 ^@ Similarity ^@ Belongs to the CbbQ/NirQ/NorQ/GpvN family. http://togogenome.org/gene/2027290:CYG50_RS09345 ^@ http://purl.uniprot.org/uniprot/A0A345LTE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS19740 ^@ http://purl.uniprot.org/uniprot/A0A345LZ25 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ArsB family.|||Cell membrane|||Involved in arsenical resistance. Thought to form the channel of an arsenite pump.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS12085 ^@ http://purl.uniprot.org/uniprot/A0A345LS03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter small permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/2027290:CYG50_RS01585 ^@ http://purl.uniprot.org/uniprot/A0A345LXG1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MerP family.|||Involved in mercury resistance. Acts as a mercury scavenger that specifically binds to a mercuric ion in the periplasm and probably passes it to the cytoplasmic mercuric reductase MerA via the mercuric transport protein MerT.|||Monomer.|||Periplasm http://togogenome.org/gene/2027290:CYG50_RS07800 ^@ http://purl.uniprot.org/uniprot/A0A345LU74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS12345 ^@ http://purl.uniprot.org/uniprot/A0A345LRV4 ^@ Function ^@ Acts as a radical domain for damaged PFL and possibly other radical proteins. http://togogenome.org/gene/2027290:CYG50_RS03520 ^@ http://purl.uniprot.org/uniprot/A0A345LWE9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2027290:CYG50_RS18095 ^@ http://purl.uniprot.org/uniprot/A0A345LZW9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/2027290:CYG50_RS01425 ^@ http://purl.uniprot.org/uniprot/A0A345LXJ0 ^@ Function|||Similarity ^@ Belongs to the DHPS family.|||Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives. http://togogenome.org/gene/2027290:CYG50_RS10940 ^@ http://purl.uniprot.org/uniprot/A0A345LSK8 ^@ Similarity ^@ Belongs to the UPF0265 family. http://togogenome.org/gene/2027290:CYG50_RS11350 ^@ http://purl.uniprot.org/uniprot/A0A345LSD3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2027290:CYG50_RS19745 ^@ http://purl.uniprot.org/uniprot/A0A345LZ24 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/2027290:CYG50_RS18160 ^@ http://purl.uniprot.org/uniprot/A0A345LZV6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2027290:CYG50_RS15210 ^@ http://purl.uniprot.org/uniprot/A0A345M1E6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HdeB family.|||Periplasm|||Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins. http://togogenome.org/gene/2027290:CYG50_RS01385 ^@ http://purl.uniprot.org/uniprot/A0A345LRM6 ^@ Similarity ^@ Belongs to the ner transcriptional regulatory family. http://togogenome.org/gene/2027290:CYG50_RS02695 ^@ http://purl.uniprot.org/uniprot/A0A345LWU5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/2027290:CYG50_RS19075 ^@ http://purl.uniprot.org/uniprot/A0A345LZE4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/2027290:CYG50_RS11065 ^@ http://purl.uniprot.org/uniprot/A0A345LSI4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/2027290:CYG50_RS20635 ^@ http://purl.uniprot.org/uniprot/A0A345LYL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS04585 ^@ http://purl.uniprot.org/uniprot/A0A345LVV1 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2027290:CYG50_RS02775 ^@ http://purl.uniprot.org/uniprot/A0A345LWT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmB/CycW/HelB family.|||Cell inner membrane|||Membrane|||Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. http://togogenome.org/gene/2027290:CYG50_RS17320 ^@ http://purl.uniprot.org/uniprot/A0A345M098 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/2027290:CYG50_RS03025 ^@ http://purl.uniprot.org/uniprot/A0A345LWN5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Fe(2+)-trafficking protein family.|||Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.|||Monomer. http://togogenome.org/gene/2027290:CYG50_RS00655 ^@ http://purl.uniprot.org/uniprot/A0A345LR97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS03490 ^@ http://purl.uniprot.org/uniprot/A0A345LWF5 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/2027290:CYG50_RS17340 ^@ http://purl.uniprot.org/uniprot/A0A345M094 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/2027290:CYG50_RS18165 ^@ http://purl.uniprot.org/uniprot/A0A345LZV5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/2027290:CYG50_RS01580 ^@ http://purl.uniprot.org/uniprot/A0A345LXG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MerT family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS02825 ^@ http://purl.uniprot.org/uniprot/A0A345LWS3 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS19330 ^@ http://purl.uniprot.org/uniprot/A0A345LZ99 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/2027290:CYG50_RS02235 ^@ http://purl.uniprot.org/uniprot/A0A345LX30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hok/gef family.|||Cell inner membrane http://togogenome.org/gene/2027290:CYG50_RS12035 ^@ http://purl.uniprot.org/uniprot/A0A345LS13 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HesB/IscA family.|||Binds 2 iron ions per dimer. The dimer may bind additional iron ions.|||Homodimer; may form tetramers and higher multimers.|||Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. http://togogenome.org/gene/2027290:CYG50_RS18185 ^@ http://purl.uniprot.org/uniprot/A0A345LZV1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/2027290:CYG50_RS02230 ^@ http://purl.uniprot.org/uniprot/A0A345LX30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hok/gef family.|||Cell inner membrane http://togogenome.org/gene/2027290:CYG50_RS22665 ^@ http://purl.uniprot.org/uniprot/A0A345LR97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS03820 ^@ http://purl.uniprot.org/uniprot/A0A345LWA0 ^@ Cofactor|||Function|||Subcellular Location Annotation ^@ Cell inner membrane|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH).|||The heme is bound between the two transmembrane subunits. http://togogenome.org/gene/2027290:CYG50_RS16050 ^@ http://purl.uniprot.org/uniprot/A0A345M0Y5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.|||Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS11310 ^@ http://purl.uniprot.org/uniprot/A0A345LSE1 ^@ Caution|||Function|||Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.|||Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2027290:CYG50_RS14680 ^@ http://purl.uniprot.org/uniprot/A0A345M393 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. http://togogenome.org/gene/2027290:CYG50_RS01190 ^@ http://purl.uniprot.org/uniprot/A0A345LRJ2 ^@ Similarity ^@ Belongs to the type IA topoisomerase family. http://togogenome.org/gene/2027290:CYG50_RS00700 ^@ http://purl.uniprot.org/uniprot/A0A345LRA4 ^@ Similarity ^@ Belongs to the site-specific recombinase resolvase family. http://togogenome.org/gene/2027290:CYG50_RS11975 ^@ http://purl.uniprot.org/uniprot/A0A345LS23 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspG family.|||Binds 1 [4Fe-4S] cluster.|||Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. http://togogenome.org/gene/2027290:CYG50_RS04675 ^@ http://purl.uniprot.org/uniprot/A0A345LVT4 ^@ Function|||Similarity ^@ Belongs to the flavodoxin family.|||Low-potential electron donor to a number of redox enzymes. http://togogenome.org/gene/2027290:CYG50_RS02310 ^@ http://purl.uniprot.org/uniprot/A0A345LX15 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/2027290:CYG50_RS12945 ^@ http://purl.uniprot.org/uniprot/A0A345M2L5 ^@ Function|||Similarity ^@ Belongs to the LpxC family.|||Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. http://togogenome.org/gene/2027290:CYG50_RS18220 ^@ http://purl.uniprot.org/uniprot/A0A345LZU4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/2027290:CYG50_RS06760 ^@ http://purl.uniprot.org/uniprot/A0A345LUQ5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the glyoxalase I family.|||Binds 1 nickel ion per subunit.|||Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.|||Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. http://togogenome.org/gene/2027290:CYG50_RS14555 ^@ http://purl.uniprot.org/uniprot/A0A345M1R3 ^@ Cofactor|||Similarity ^@ Belongs to the PTPS family. QueD subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/2027290:CYG50_RS18130 ^@ http://purl.uniprot.org/uniprot/A0A345LZW2 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/2027290:CYG50_RS18050 ^@ http://purl.uniprot.org/uniprot/A0A345LZX6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/2027290:CYG50_RS22670 ^@ http://purl.uniprot.org/uniprot/A0A345LXJ0 ^@ Function|||Similarity ^@ Belongs to the DHPS family.|||Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives. http://togogenome.org/gene/2027290:CYG50_RS00765 ^@ http://purl.uniprot.org/uniprot/A0A345LRB3 ^@ Similarity ^@ Belongs to the class-A beta-lactamase family. http://togogenome.org/gene/2027290:CYG50_RS18145 ^@ http://purl.uniprot.org/uniprot/A0A345LZV9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/2027290:CYG50_RS13300 ^@ http://purl.uniprot.org/uniprot/A0A345M2F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the thioredoxin family. DsbE subfamily.|||Cell inner membrane http://togogenome.org/gene/2027290:CYG50_RS11615 ^@ http://purl.uniprot.org/uniprot/A0A345LS84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS04890 ^@ http://purl.uniprot.org/uniprot/A0A345LVP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribosome modulation factor family.|||Cytoplasm|||During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes). http://togogenome.org/gene/2027290:CYG50_RS19035 ^@ http://purl.uniprot.org/uniprot/A0A345LZF1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/2027290:CYG50_RS05220 ^@ http://purl.uniprot.org/uniprot/A0A345LVJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MgtC/SapB family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS06285 ^@ http://purl.uniprot.org/uniprot/A0A345LUZ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-3 family.|||Cytoplasm|||IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.|||Monomer. http://togogenome.org/gene/2027290:CYG50_RS16370 ^@ http://purl.uniprot.org/uniprot/A0A8I2AP55 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/2027290:CYG50_RS03965 ^@ http://purl.uniprot.org/uniprot/A0A345LW73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.|||Belongs to the AcrZ family.|||Cell membrane|||Part of the AcrA-AcrB-AcrZ-TolC efflux pump, interacts directly with AcrB. http://togogenome.org/gene/2027290:CYG50_RS05630 ^@ http://purl.uniprot.org/uniprot/A0A345LVB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FliS family.|||cytosol http://togogenome.org/gene/2027290:CYG50_RS22615 ^@ http://purl.uniprot.org/uniprot/A0A345LXK9 ^@ Similarity ^@ Belongs to the transposase 7 family. http://togogenome.org/gene/2027290:CYG50_RS09615 ^@ http://purl.uniprot.org/uniprot/A0A345LTA0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2027290:CYG50_RS07795 ^@ http://purl.uniprot.org/uniprot/A0A345LU75 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtJ subfamily.|||Catalyzes the excretion of spermidine.|||Cell membrane|||Forms a complex with MdtI.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS02130 ^@ http://purl.uniprot.org/uniprot/A0A345LX52 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.|||Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers. http://togogenome.org/gene/2027290:CYG50_RS04355 ^@ http://purl.uniprot.org/uniprot/A0A345LVZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/2027290:CYG50_RS18420 ^@ http://purl.uniprot.org/uniprot/A0A345LZR6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.|||Binds 1 zinc ion per subunit.|||Binds the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2027290:CYG50_RS12725 ^@ http://purl.uniprot.org/uniprot/A0A345M2Q5 ^@ Similarity ^@ Belongs to the SdhE FAD assembly factor family. http://togogenome.org/gene/2027290:CYG50_RS07075 ^@ http://purl.uniprot.org/uniprot/A0A345LUK0 ^@ Function ^@ Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. http://togogenome.org/gene/2027290:CYG50_RS05565 ^@ http://purl.uniprot.org/uniprot/A0A345LVC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliG family.|||Cell inner membrane|||FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS14505 ^@ http://purl.uniprot.org/uniprot/A0A345M1S3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IspF family.|||Binds 1 divalent metal cation per subunit.|||Homotrimer.|||Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). http://togogenome.org/gene/2027290:CYG50_RS04895 ^@ http://purl.uniprot.org/uniprot/A0A345LVP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thioester dehydratase family. FabA subfamily.|||Cytoplasm|||Homodimer.|||Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. http://togogenome.org/gene/2027290:CYG50_RS00315 ^@ http://purl.uniprot.org/uniprot/A0A345LR36 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family. http://togogenome.org/gene/2027290:CYG50_RS01470 ^@ http://purl.uniprot.org/uniprot/A0A345LXI4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2027290:CYG50_RS18135 ^@ http://purl.uniprot.org/uniprot/A0A345LZW1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/2027290:CYG50_RS10890 ^@ http://purl.uniprot.org/uniprot/A0A345LSL7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/2027290:CYG50_RS00600 ^@ http://purl.uniprot.org/uniprot/A0A345LR86 ^@ Similarity ^@ Belongs to the class-A beta-lactamase family. http://togogenome.org/gene/2027290:CYG50_RS00320 ^@ http://purl.uniprot.org/uniprot/A0A345LR37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS09065 ^@ http://purl.uniprot.org/uniprot/A0A345LTJ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell inner membrane|||Membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/2027290:CYG50_RS16740 ^@ http://purl.uniprot.org/uniprot/A0A345M0K2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2027290:CYG50_RS18410 ^@ http://purl.uniprot.org/uniprot/A0A345LZR8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MetJ family.|||Cytoplasm|||Does not bind DNA by a helix-turn-helix motif.|||Homodimer.|||This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. http://togogenome.org/gene/2027290:CYG50_RS01680 ^@ http://purl.uniprot.org/uniprot/A0A345LXE2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.|||Homohexamer; trimer of homodimers. http://togogenome.org/gene/2027290:CYG50_RS21215 ^@ http://purl.uniprot.org/uniprot/A0A345LYA9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2027290:CYG50_RS05310 ^@ http://purl.uniprot.org/uniprot/A0A345LVH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MotA family.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS12920 ^@ http://purl.uniprot.org/uniprot/A0A345M2L9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DNA gyrase inhibitor YacG family.|||Binds 1 zinc ion.|||Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.|||Interacts with GyrB. http://togogenome.org/gene/2027290:CYG50_RS13315 ^@ http://purl.uniprot.org/uniprot/A0A345M2E8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmD/CycX/HelD family.|||Cell inner membrane|||Membrane|||Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. http://togogenome.org/gene/2027290:CYG50_RS14515 ^@ http://purl.uniprot.org/uniprot/A0A345M1S1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsB family.|||Cell inner membrane|||Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.|||Part of a complex composed of FtsB, FtsL and FtsQ. http://togogenome.org/gene/2027290:CYG50_RS17405 ^@ http://purl.uniprot.org/uniprot/A0A345M084 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/2027290:CYG50_RS12305 ^@ http://purl.uniprot.org/uniprot/A0A345LRW2 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/2027290:CYG50_RS00340 ^@ http://purl.uniprot.org/uniprot/A0A345LR97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS03600 ^@ http://purl.uniprot.org/uniprot/A0A345M313 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS18535 ^@ http://purl.uniprot.org/uniprot/A0A345LZP7 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/2027290:CYG50_RS02135 ^@ http://purl.uniprot.org/uniprot/A0A345LX51 ^@ Function|||Similarity ^@ Belongs to the NusB family.|||Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. http://togogenome.org/gene/2027290:CYG50_RS05300 ^@ http://purl.uniprot.org/uniprot/A0A345LVH5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FlhD family.|||Cytoplasm|||Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.|||Homodimer; disulfide-linked. Forms a heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.|||The C-terminal region contains a putative helix-turn-helix (HTH) motif, suggesting that this region may bind DNA. http://togogenome.org/gene/2027290:CYG50_RS15965 ^@ http://purl.uniprot.org/uniprot/A0A345M102 ^@ Similarity ^@ Belongs to the leucine-binding protein family. http://togogenome.org/gene/2027290:CYG50_RS01275 ^@ http://purl.uniprot.org/uniprot/A0A345LRK7 ^@ Similarity ^@ Belongs to the ParB family. http://togogenome.org/gene/2027290:CYG50_RS11855 ^@ http://purl.uniprot.org/uniprot/A0A345LS46 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2027290:CYG50_RS06315 ^@ http://purl.uniprot.org/uniprot/A0A345LUY6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial histone-like protein family.|||Heterodimer of an alpha and a beta chain.|||This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. http://togogenome.org/gene/2027290:CYG50_RS00725 ^@ http://purl.uniprot.org/uniprot/A0A345LRA8 ^@ Similarity ^@ Belongs to the site-specific recombinase resolvase family. http://togogenome.org/gene/2027290:CYG50_RS21225 ^@ http://purl.uniprot.org/uniprot/A0A345LYA7 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/2027290:CYG50_RS14200 ^@ http://purl.uniprot.org/uniprot/A0A345M1Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS15990 ^@ http://purl.uniprot.org/uniprot/A0A345M0Z7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Homodimer. Forms a membrane-associated complex with FtsX.|||Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring. http://togogenome.org/gene/2027290:CYG50_RS20630 ^@ http://purl.uniprot.org/uniprot/A0A345M349 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell inner membrane|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/2027290:CYG50_RS00605 ^@ http://purl.uniprot.org/uniprot/A0A345LR87 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. Aminoglycoside resistance family.|||Specifically methylates the N7 position of guanine 1405 in 16S rRNA. Confers resistance to various aminoglycosides. http://togogenome.org/gene/2027290:CYG50_RS21220 ^@ http://purl.uniprot.org/uniprot/A0A345LYA8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NusG family.|||Monomer. Interacts with the transcription termination factor Rho and with RNA polymerase.|||Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination. http://togogenome.org/gene/2027290:CYG50_RS03980 ^@ http://purl.uniprot.org/uniprot/A0A345LW70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell inner membrane|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/2027290:CYG50_RS10200 ^@ http://purl.uniprot.org/uniprot/A0A345LSZ9 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/2027290:CYG50_RS15640 ^@ http://purl.uniprot.org/uniprot/A0A345M164 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/2027290:CYG50_RS19555 ^@ http://purl.uniprot.org/uniprot/A0A345LZ54 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS14785 ^@ http://purl.uniprot.org/uniprot/A0A345M1M5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/2027290:CYG50_RS02465 ^@ http://purl.uniprot.org/uniprot/A0A345LWY8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EcpA/MatB fimbrillin family.|||Fimbrium|||Self-associates. Forms filaments. Interacts with EcpD. http://togogenome.org/gene/2027290:CYG50_RS18120 ^@ http://purl.uniprot.org/uniprot/A0A345LZW4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2027290:CYG50_RS05435 ^@ http://purl.uniprot.org/uniprot/A0A345LVE9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family.|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each. http://togogenome.org/gene/2027290:CYG50_RS22715 ^@ http://purl.uniprot.org/uniprot/A0A345LXJ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2027290:CYG50_RS05210 ^@ http://purl.uniprot.org/uniprot/A0A345LVJ2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2027290:CYG50_RS01780 ^@ http://purl.uniprot.org/uniprot/A0A345LXC3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the YjjX NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Homodimer.|||Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/2027290:CYG50_RS17435 ^@ http://purl.uniprot.org/uniprot/A0A345M078 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Catalyzes the reversible oxidation of malate to oxaloacetate.|||Homodimer. http://togogenome.org/gene/2027290:CYG50_RS03275 ^@ http://purl.uniprot.org/uniprot/A0A345LWI9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).|||Belongs to the CsrA/RsmA family.|||Cytoplasm|||Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core. http://togogenome.org/gene/2027290:CYG50_RS17555 ^@ http://purl.uniprot.org/uniprot/A0A345M057 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6. http://togogenome.org/gene/2027290:CYG50_RS04735 ^@ http://purl.uniprot.org/uniprot/A0A345LVS2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial histone-like protein family.|||Heterodimer of an alpha and a beta chain.|||This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. http://togogenome.org/gene/2027290:CYG50_RS01465 ^@ http://purl.uniprot.org/uniprot/A0A345LXI5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/2027290:CYG50_RS12990 ^@ http://purl.uniprot.org/uniprot/A0A345M2K6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell membrane|||Membrane http://togogenome.org/gene/2027290:CYG50_RS04280 ^@ http://purl.uniprot.org/uniprot/A0A345LW12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/2027290:CYG50_RS03535 ^@ http://purl.uniprot.org/uniprot/A0A345LWE6 ^@ Similarity ^@ Belongs to the UPF0250 family.