http://togogenome.org/gene/224914:BME_RS03815 ^@ http://purl.uniprot.org/uniprot/Q8YHN3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/224914:BME_RS07515 ^@ http://purl.uniprot.org/uniprot/Q8YFL5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DHBP synthase family.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Homodimer.|||In the C-terminal section; belongs to the GTP cyclohydrolase II family.|||In the N-terminal section; belongs to the DHBP synthase family. http://togogenome.org/gene/224914:BME_RS07725 ^@ http://purl.uniprot.org/uniprot/Q8YFH2 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/224914:BME_RS01145 ^@ http://purl.uniprot.org/uniprot/P67539 ^@ Domain|||Similarity ^@ Belongs to the PurH family.|||The IMP cyclohydrolase activity resides in the N-terminal region. http://togogenome.org/gene/224914:BME_RS10480 ^@ http://purl.uniprot.org/uniprot/Q8YDW3 ^@ Function|||Subunit ^@ E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).|||Homodimer. Part of the 2-oxoglutarate dehydrogenase (OGDH) complex composed of E1 (2-oxoglutarate dehydrogenase), E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase); the complex contains multiple copies of the three enzymatic components (E1, E2 and E3). http://togogenome.org/gene/224914:BME_RS03080 ^@ http://purl.uniprot.org/uniprot/Q8YI27 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/224914:BME_RS06080 ^@ http://purl.uniprot.org/uniprot/Q8YGF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.|||Cell inner membrane|||Cell membrane|||Membrane http://togogenome.org/gene/224914:BME_RS12280 ^@ http://purl.uniprot.org/uniprot/Q8YCV1 ^@ Similarity ^@ Belongs to the SorC transcriptional regulatory family. http://togogenome.org/gene/224914:BME_RS00050 ^@ http://purl.uniprot.org/uniprot/Q8YJS2 ^@ Function|||Similarity ^@ Belongs to the ParB family.|||Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication. http://togogenome.org/gene/224914:BME_RS13610 ^@ http://purl.uniprot.org/uniprot/D0B707 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Cell inner membrane|||Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP. http://togogenome.org/gene/224914:BME_RS13155 ^@ http://purl.uniprot.org/uniprot/Q8YCC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/224914:BME_RS04525 ^@ http://purl.uniprot.org/uniprot/Q8YH95 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRA-CH family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/224914:BME_RS13490 ^@ http://purl.uniprot.org/uniprot/Q8YC59 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/224914:BME_RS04250 ^@ http://purl.uniprot.org/uniprot/Q8YHF0 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/224914:BME_RS05955 ^@ http://purl.uniprot.org/uniprot/Q8YGH6 ^@ Similarity ^@ Belongs to the UPF0174 family. http://togogenome.org/gene/224914:BME_RS06680 ^@ http://purl.uniprot.org/uniprot/Q8YG35 ^@ Function|||Similarity ^@ Belongs to the GlnE family.|||Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell. http://togogenome.org/gene/224914:BME_RS12845 ^@ http://purl.uniprot.org/uniprot/Q8YCI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Membrane http://togogenome.org/gene/224914:BME_RS09075 ^@ http://purl.uniprot.org/uniprot/Q8YEP5 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/224914:BME_RS09830 ^@ http://purl.uniprot.org/uniprot/Q8YE93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/224914:BME_RS06055 ^@ http://purl.uniprot.org/uniprot/Q8YGF5 ^@ Similarity ^@ Belongs to the GppA/Ppx family. http://togogenome.org/gene/224914:BME_RS07760 ^@ http://purl.uniprot.org/uniprot/Q8YFG4 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/224914:BME_RS13920 ^@ http://purl.uniprot.org/uniprot/Q8YBX4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS02370 ^@ http://purl.uniprot.org/uniprot/Q8YIH0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.|||Membrane|||The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein. http://togogenome.org/gene/224914:BME_RS16800 ^@ http://purl.uniprot.org/uniprot/Q8YEL5 ^@ Similarity ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family. http://togogenome.org/gene/224914:BME_RS12580 ^@ http://purl.uniprot.org/uniprot/Q8YCN7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.|||Cell inner membrane|||Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (NikD and NikE), two transmembrane proteins (NikB and NikC) and a solute-binding protein (NikA). http://togogenome.org/gene/224914:BME_RS10730 ^@ http://purl.uniprot.org/uniprot/Q8YDR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Membrane http://togogenome.org/gene/224914:BME_RS07580 ^@ http://purl.uniprot.org/uniprot/Q8YFK1 ^@ Cofactor|||Similarity ^@ Belongs to the GARS family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/224914:BME_RS08635 ^@ http://purl.uniprot.org/uniprot/Q8YEY9 ^@ Function|||Similarity ^@ Belongs to the TenA family.|||Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. http://togogenome.org/gene/224914:BME_RS13335 ^@ http://purl.uniprot.org/uniprot/Q8YC87 ^@ Similarity ^@ Belongs to the 3-oxoacid CoA-transferase subunit B family. http://togogenome.org/gene/224914:BME_RS01160 ^@ http://purl.uniprot.org/uniprot/Q8YJ50 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell inner membrane http://togogenome.org/gene/224914:BME_RS03895 ^@ http://purl.uniprot.org/uniprot/P66350 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/224914:BME_RS10745 ^@ http://purl.uniprot.org/uniprot/Q8YDR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 1 family.|||Periplasm http://togogenome.org/gene/224914:BME_RS03290 ^@ http://purl.uniprot.org/uniprot/Q8YHY0 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/224914:BME_RS00400 ^@ http://purl.uniprot.org/uniprot/Q8YJJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS15300 ^@ http://purl.uniprot.org/uniprot/Q8YB49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/224914:BME_RS00795 ^@ http://purl.uniprot.org/uniprot/Q8YJB8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsK/SpoIIIE/SftA family.|||Cell inner membrane|||Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase (By similarity).|||Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).|||Homohexamer. Forms a ring that surrounds DNA (By similarity). http://togogenome.org/gene/224914:BME_RS01440 ^@ http://purl.uniprot.org/uniprot/P52558 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/224914:BME_RS02655 ^@ http://purl.uniprot.org/uniprot/Q8YIB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoD/SigA subfamily.|||Cytoplasm|||Interacts transiently with the RNA polymerase catalytic core.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. http://togogenome.org/gene/224914:BME_RS01900 ^@ http://purl.uniprot.org/uniprot/Q8YIQ7 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/224914:BME_RS01475 ^@ http://purl.uniprot.org/uniprot/Q8YIY5 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/224914:BME_RS04830 ^@ http://purl.uniprot.org/uniprot/Q8YH35 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.|||In the C-terminal section; belongs to the NAD synthetase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/224914:BME_RS06230 ^@ http://purl.uniprot.org/uniprot/Q8YGC2 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. http://togogenome.org/gene/224914:BME_RS13645 ^@ http://purl.uniprot.org/uniprot/Q8YC29 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. RimO subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS03875 ^@ http://purl.uniprot.org/uniprot/Q8YHM1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/224914:BME_RS02000 ^@ http://purl.uniprot.org/uniprot/Q8YIP2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/224914:BME_RS00790 ^@ http://purl.uniprot.org/uniprot/Q8YJB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/224914:BME_RS13650 ^@ http://purl.uniprot.org/uniprot/P49944 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the bacterioferritin family.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.|||Binds 2 iron ions per subunit. The catalytic dinuclear iron-binding site within each subunit is known as the ferroxidase center.|||Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.|||Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex. http://togogenome.org/gene/224914:BME_RS01190 ^@ http://purl.uniprot.org/uniprot/Q8YJ44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS01095 ^@ http://purl.uniprot.org/uniprot/Q8YJ64 ^@ Function|||Similarity ^@ Belongs to the beta-class carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/224914:BME_RS09890 ^@ http://purl.uniprot.org/uniprot/Q8YE79 ^@ Function|||Similarity|||Subunit ^@ Belongs to the OMP decarboxylase family. Type 1 subfamily.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).|||Homodimer. http://togogenome.org/gene/224914:BME_RS05965 ^@ http://purl.uniprot.org/uniprot/Q8YGH4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.|||Cell inner membrane|||Homodimer.|||Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. http://togogenome.org/gene/224914:BME_RS05215 ^@ http://purl.uniprot.org/uniprot/Q8YGW3 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/224914:BME_RS03320 ^@ http://purl.uniprot.org/uniprot/Q8YHX5 ^@ Similarity ^@ Belongs to the UPF0053 family. Hemolysin C subfamily. http://togogenome.org/gene/224914:BME_RS06515 ^@ http://purl.uniprot.org/uniprot/Q8YG65 ^@ Disruption Phenotype|||Function|||Similarity ^@ Belongs to the RelA/SpoT family.|||Cells show morphological abnormalities such as branching and swelling forms during vegetative growth. It is unable to persist during stationary phase, presumably because of nutrient limitation occurring during this growth phase. It shows an important growth defect in human HeLa cells and in ovine macrophages MOCL3. At four weeks post infection the number of viable bacteria (deletion mutant) in mouse spleen is markedly reduced compared to the wild-type. The deletion mutant shows very low levels or absence of VirB at all time points of growth.|||Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. It is necessary for persistence in mice, essential for intracellular growth of Brucella and required for expression of the type IV secretion system VirB and therefore plays a role in adaptation of Brucella to its intracellular host environment. http://togogenome.org/gene/224914:BME_RS03755 ^@ http://purl.uniprot.org/uniprot/Q8GH23 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity).|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex (By similarity).|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/224914:BME_RS09345 ^@ http://purl.uniprot.org/uniprot/Q8YEJ3 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/224914:BME_RS14680 ^@ http://purl.uniprot.org/uniprot/Q8YBI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Cell membrane http://togogenome.org/gene/224914:BME_RS04415 ^@ http://purl.uniprot.org/uniprot/P63814 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/224914:BME_RS11845 ^@ http://purl.uniprot.org/uniprot/Q8YD37 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS05630 ^@ http://purl.uniprot.org/uniprot/Q8YGN5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PurS family.|||Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/224914:BME_RS08220 ^@ http://purl.uniprot.org/uniprot/Q7CNT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UreE family.|||Cytoplasm|||Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. http://togogenome.org/gene/224914:BME_RS11355 ^@ http://purl.uniprot.org/uniprot/Q8YDE1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.|||Cytoplasm|||Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/224914:BME_RS07960 ^@ http://purl.uniprot.org/uniprot/Q8YFC4 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/224914:BME_RS03935 ^@ http://purl.uniprot.org/uniprot/P67008 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS11545 ^@ http://purl.uniprot.org/uniprot/P66242 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/224914:BME_RS12715 ^@ http://purl.uniprot.org/uniprot/Q8YCL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AzlC family.|||Membrane http://togogenome.org/gene/224914:BME_RS07140 ^@ http://purl.uniprot.org/uniprot/Q8YFU3 ^@ Similarity ^@ Belongs to the polysaccharide synthase family. http://togogenome.org/gene/224914:BME_RS11535 ^@ http://purl.uniprot.org/uniprot/Q8YDA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.|||Cell inner membrane|||Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.|||Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. http://togogenome.org/gene/224914:BME_RS14800 ^@ http://purl.uniprot.org/uniprot/Q8YBF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.|||Membrane http://togogenome.org/gene/224914:BME_RS12615 ^@ http://purl.uniprot.org/uniprot/Q8YCN1 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/224914:BME_RS11735 ^@ http://purl.uniprot.org/uniprot/Q8YD64 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/224914:BME_RS15475 ^@ http://purl.uniprot.org/uniprot/Q8YB15 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family.|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each. http://togogenome.org/gene/224914:BME_RS06380 ^@ http://purl.uniprot.org/uniprot/Q8YG94 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/224914:BME_RS08090 ^@ http://purl.uniprot.org/uniprot/Q8YF97 ^@ Function|||Similarity|||Subunit ^@ Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.|||Homotetramer.|||Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP. http://togogenome.org/gene/224914:BME_RS14390 ^@ http://purl.uniprot.org/uniprot/Q8YBP0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial solute-binding protein 5 family.|||Periplasm|||Probably part of an ABC transporter complex that could be involved in peptide import.|||The complex is composed of two ATP-binding proteins (BMEII0863 and BMEII0864), two transmembrane proteins (BMEII0860 and BMEII0861) and a solute-binding protein (BMEII0859). http://togogenome.org/gene/224914:BME_RS01615 ^@ http://purl.uniprot.org/uniprot/P66742 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvA family.|||Cytoplasm|||Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.|||Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/224914:BME_RS05890 ^@ http://purl.uniprot.org/uniprot/Q8YGI7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COX15/CtaA family. Type 2 subfamily.|||Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.|||Cell membrane|||Interacts with CtaB. http://togogenome.org/gene/224914:BME_RS03700 ^@ http://purl.uniprot.org/uniprot/P64024 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/224914:BME_RS04370 ^@ http://purl.uniprot.org/uniprot/Q8YHC6 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/224914:BME_RS00880 ^@ http://purl.uniprot.org/uniprot/Q8YJA1 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/224914:BME_RS13770 ^@ http://purl.uniprot.org/uniprot/Q8YC05 ^@ Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Homodimer. http://togogenome.org/gene/224914:BME_RS00460 ^@ http://purl.uniprot.org/uniprot/Q8YJI4 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/224914:BME_RS09750 ^@ http://purl.uniprot.org/uniprot/Q8YEA9 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. http://togogenome.org/gene/224914:BME_RS01585 ^@ http://purl.uniprot.org/uniprot/Q8YIW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/224914:BME_RS12820 ^@ http://purl.uniprot.org/uniprot/Q8YCI8 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/224914:BME_RS00735 ^@ http://purl.uniprot.org/uniprot/Q8YJD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/224914:BME_RS15710 ^@ http://purl.uniprot.org/uniprot/Q8YAW8 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/224914:BME_RS00200 ^@ http://purl.uniprot.org/uniprot/Q8YJN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0053 family. Hemolysin C subfamily.|||Membrane http://togogenome.org/gene/224914:BME_RS11220 ^@ http://purl.uniprot.org/uniprot/Q8YDG6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial solute-binding protein 5 family.|||Periplasm|||Probably part of an ABC transporter complex that could be involved in peptide import.|||The complex is composed of two ATP-binding proteins (BMEII0205 and BMEII0206), two transmembrane proteins (BMEII0207/BMEII0208 and BMEII0209) and a solute-binding protein (BMEII0210). http://togogenome.org/gene/224914:BME_RS12935 ^@ http://purl.uniprot.org/uniprot/P62921 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/224914:BME_RS09940 ^@ http://purl.uniprot.org/uniprot/P66265 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/224914:BME_RS14635 ^@ http://purl.uniprot.org/uniprot/Q8YBJ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS09465 ^@ http://purl.uniprot.org/uniprot/Q8YEG8 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/224914:BME_RS09910 ^@ http://purl.uniprot.org/uniprot/Q8YE76 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock (By similarity). http://togogenome.org/gene/224914:BME_RS11455 ^@ http://purl.uniprot.org/uniprot/Q8YDB9 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. http://togogenome.org/gene/224914:BME_RS15055 ^@ http://purl.uniprot.org/uniprot/Q8YB99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/224914:BME_RS09455 ^@ http://purl.uniprot.org/uniprot/Q8YEH0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DnaX/STICHEL family.|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/224914:BME_RS13085 ^@ http://purl.uniprot.org/uniprot/Q8YCE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 1 family.|||Part of a binding-protein-dependent transport system for a sugar.|||Periplasm http://togogenome.org/gene/224914:BME_RS11500 ^@ http://purl.uniprot.org/uniprot/Q8YDB0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M20A family. DapE subfamily.|||Binds 2 Zn(2+) or Co(2+) ions per subunit.|||Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.|||Homodimer. http://togogenome.org/gene/224914:BME_RS09450 ^@ http://purl.uniprot.org/uniprot/Q8YEH1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/224914:BME_RS00475 ^@ http://purl.uniprot.org/uniprot/Q8YJI0 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/224914:BME_RS13545 ^@ http://purl.uniprot.org/uniprot/Q8YC50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LPG synthase family.|||Membrane http://togogenome.org/gene/224914:BME_RS12030 ^@ http://purl.uniprot.org/uniprot/Q8YD01 ^@ Similarity ^@ Belongs to the surface antigen msp4 family. http://togogenome.org/gene/224914:BME_RS11115 ^@ http://purl.uniprot.org/uniprot/Q8YDI8 ^@ Similarity ^@ Belongs to the four-carbon acid sugar kinase family. http://togogenome.org/gene/224914:BME_RS04150 ^@ http://purl.uniprot.org/uniprot/P0A3P4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the transferase hexapeptide repeat family. LpxD subfamily.|||Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.|||Homotrimer. http://togogenome.org/gene/224914:BME_RS06510 ^@ http://purl.uniprot.org/uniprot/P65910 ^@ Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer. http://togogenome.org/gene/224914:BME_RS02355 ^@ http://purl.uniprot.org/uniprot/Q8YIH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/224914:BME_RS01505 ^@ http://purl.uniprot.org/uniprot/Q8YIX9 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/224914:BME_RS14880 ^@ http://purl.uniprot.org/uniprot/Q8YBD5 ^@ Cofactor|||Subcellular Location Annotation ^@ Binds 1 copper ion per subunit.|||Periplasm http://togogenome.org/gene/224914:BME_RS05705 ^@ http://purl.uniprot.org/uniprot/Q8YGM0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.|||Cell inner membrane|||Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.|||The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE). http://togogenome.org/gene/224914:BME_RS04555 ^@ http://purl.uniprot.org/uniprot/Q8YH89 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/224914:BME_RS05800 ^@ http://purl.uniprot.org/uniprot/Q8YGK1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 20 kDa subunit family.|||Binds 1 [4Fe-4S] cluster.|||Cell inner membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity). http://togogenome.org/gene/224914:BME_RS10100 ^@ http://purl.uniprot.org/uniprot/P64351 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA-PH family.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS09540 ^@ http://purl.uniprot.org/uniprot/Q8YEF2 ^@ Similarity ^@ Belongs to the HMG-CoA lyase family. http://togogenome.org/gene/224914:BME_RS04420 ^@ http://purl.uniprot.org/uniprot/Q8YHB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).|||Periplasm http://togogenome.org/gene/224914:BME_RS00520 ^@ http://purl.uniprot.org/uniprot/Q8YJH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.|||Cell inner membrane|||Cell membrane|||Membrane http://togogenome.org/gene/224914:BME_RS03490 ^@ http://purl.uniprot.org/uniprot/Q8YHU2 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/224914:BME_RS00030 ^@ http://purl.uniprot.org/uniprot/Q8YJS6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits. http://togogenome.org/gene/224914:BME_RS07160 ^@ http://purl.uniprot.org/uniprot/Q8YFT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BioY family.|||Cell membrane http://togogenome.org/gene/224914:BME_RS12680 ^@ http://purl.uniprot.org/uniprot/Q8YCL8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/224914:BME_RS05235 ^@ http://purl.uniprot.org/uniprot/Q8YGV9 ^@ Function|||Similarity ^@ Belongs to the anhydro-N-acetylmuramic acid kinase family.|||Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. http://togogenome.org/gene/224914:BME_RS05675 ^@ http://purl.uniprot.org/uniprot/Q8YGM6 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TtcA family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.|||Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.|||Cytoplasm|||Homodimer.|||The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster. http://togogenome.org/gene/224914:BME_RS04650 ^@ http://purl.uniprot.org/uniprot/Q8YH70 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/224914:BME_RS05100 ^@ http://purl.uniprot.org/uniprot/Q8YGY6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Monomer and homodimer. http://togogenome.org/gene/224914:BME_RS11275 ^@ http://purl.uniprot.org/uniprot/Q8YDF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Cell membrane http://togogenome.org/gene/224914:BME_RS05275 ^@ http://purl.uniprot.org/uniprot/Q8YGV2 ^@ Similarity|||Subcellular Location Annotation ^@ Cell inner membrane|||In the C-terminal section; belongs to the transpeptidase family.|||In the N-terminal section; belongs to the glycosyltransferase 51 family.|||Membrane http://togogenome.org/gene/224914:BME_RS04120 ^@ http://purl.uniprot.org/uniprot/Q8YHH4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by GTP. Inhibited by UTP.|||Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/224914:BME_RS13760 ^@ http://purl.uniprot.org/uniprot/Q8YC08 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/224914:BME_RS11205 ^@ http://purl.uniprot.org/uniprot/Q8YDH0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system (By similarity).|||The complex is composed of two ATP-binding proteins (BMEII0205 and BMEII0206), two transmembrane proteins (BMEII0207/BMEII0208 and BMEII0209) and a solute-binding protein (BMEII0210). http://togogenome.org/gene/224914:BME_RS10220 ^@ http://purl.uniprot.org/uniprot/Q8YE14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell inner membrane|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/224914:BME_RS05650 ^@ http://purl.uniprot.org/uniprot/Q8YGN1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/224914:BME_RS07590 ^@ http://purl.uniprot.org/uniprot/Q8YFJ9 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/224914:BME_RS12235 ^@ http://purl.uniprot.org/uniprot/Q8YCW0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Cell membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/224914:BME_RS02120 ^@ http://purl.uniprot.org/uniprot/Q7CNV1 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Essential protein that plays a role in the control of cell division, possibly through the transcriptional regulation of ccrM, rpoD, pleC, minC and ftsZ genes. http://togogenome.org/gene/224914:BME_RS05570 ^@ http://purl.uniprot.org/uniprot/P63450 ^@ Function|||PTM|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group (By similarity).|||Carrier of the growing fatty acid chain in fatty acid biosynthesis. Is involved in the transfer of long hydroxylated fatty acids to lipid A (By similarity).|||Cytoplasm http://togogenome.org/gene/224914:BME_RS09645 ^@ http://purl.uniprot.org/uniprot/Q8YED0 ^@ Similarity ^@ Belongs to the peptidase M17 family. http://togogenome.org/gene/224914:BME_RS14850 ^@ http://purl.uniprot.org/uniprot/Q8YBE1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase U32 family. UbiU subfamily.|||Forms an heterodimer with UbiV.|||Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiV, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway. http://togogenome.org/gene/224914:BME_RS12770 ^@ http://purl.uniprot.org/uniprot/Q8YCK0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the carboxylate-amine ligase family. Glutamate--cysteine ligase type 2 subfamily.|||Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily.|||Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC).|||Homodimer or monomer when oxidized or reduced, respectively.|||chloroplast http://togogenome.org/gene/224914:BME_RS07365 ^@ http://purl.uniprot.org/uniprot/Q8YFP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transglycosylase MltG family.|||Cell inner membrane|||Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. http://togogenome.org/gene/224914:BME_RS13240 ^@ http://purl.uniprot.org/uniprot/Q8YCA7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial solute-binding protein 1 family.|||Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Binds G3P.|||Periplasm|||The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB). http://togogenome.org/gene/224914:BME_RS07930 ^@ http://purl.uniprot.org/uniprot/Q8YFD1 ^@ Similarity ^@ Belongs to the ferredoxin--NADP reductase type 1 family. http://togogenome.org/gene/224914:BME_RS09740 ^@ http://purl.uniprot.org/uniprot/Q8YEB1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/224914:BME_RS10445 ^@ http://purl.uniprot.org/uniprot/Q8YDX1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MgtC/SapB family.|||Cell inner membrane|||Virulence factor required for growth in low Mg(2+) medium and for intramacrophage survival. May be involved in regulating membrane potential by activating Na(+)/K(+)-ATPase (By similarity). http://togogenome.org/gene/224914:BME_RS03605 ^@ http://purl.uniprot.org/uniprot/Q8YHS1 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/224914:BME_RS13015 ^@ http://purl.uniprot.org/uniprot/Q8YCF2 ^@ Function|||Similarity ^@ Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.|||Belongs to the AhpD family. http://togogenome.org/gene/224914:BME_RS04720 ^@ http://purl.uniprot.org/uniprot/Q8YH55 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DksA family.|||Cytoplasm|||Interacts directly with the RNA polymerase.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. http://togogenome.org/gene/224914:BME_RS14990 ^@ http://purl.uniprot.org/uniprot/Q8YBB2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the multicopper oxidase family.|||Binds 1 Cu(+) ion.|||Homotrimer.|||Periplasm http://togogenome.org/gene/224914:BME_RS01235 ^@ http://purl.uniprot.org/uniprot/P63660 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/224914:BME_RS11190 ^@ http://purl.uniprot.org/uniprot/Q8YDH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 5 family.|||Periplasm http://togogenome.org/gene/224914:BME_RS13575 ^@ http://purl.uniprot.org/uniprot/Q8YC44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.|||Cytoplasm|||In the C-terminal section; belongs to the helicase family. RecG subfamily.|||In the N-terminal section; belongs to the UvrB family. http://togogenome.org/gene/224914:BME_RS10345 ^@ http://purl.uniprot.org/uniprot/P0C537 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/224914:BME_RS09620 ^@ http://purl.uniprot.org/uniprot/P66501 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/224914:BME_RS13840 ^@ http://purl.uniprot.org/uniprot/Q8YBZ0 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/224914:BME_RS09415 ^@ http://purl.uniprot.org/uniprot/Q8YEH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Cell membrane|||Membrane http://togogenome.org/gene/224914:BME_RS04265 ^@ http://purl.uniprot.org/uniprot/Q8YHE7 ^@ Function|||Subunit ^@ Heterodimer of an alpha and a beta chain.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/224914:BME_RS05240 ^@ http://purl.uniprot.org/uniprot/Q8YGV8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/224914:BME_RS02185 ^@ http://purl.uniprot.org/uniprot/Q8YIK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Cell membrane|||Membrane http://togogenome.org/gene/224914:BME_RS10115 ^@ http://purl.uniprot.org/uniprot/Q8YE35 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/224914:BME_RS11045 ^@ http://purl.uniprot.org/uniprot/Q8YDJ6 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily. http://togogenome.org/gene/224914:BME_RS02335 ^@ http://purl.uniprot.org/uniprot/P63850 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aerobic coproporphyrinogen-III oxidase family.|||Cytoplasm|||Homodimer.|||Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. http://togogenome.org/gene/224914:BME_RS13425 ^@ http://purl.uniprot.org/uniprot/P66215 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/224914:BME_RS06655 ^@ http://purl.uniprot.org/uniprot/Q8YG40 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS08710 ^@ http://purl.uniprot.org/uniprot/Q8YEX3 ^@ Function|||Similarity|||Subunit ^@ APS kinase catalyzes the synthesis of activated sulfate.|||Belongs to the APS kinase family.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.|||Catalyzes the synthesis of activated sulfate.|||Heterodimer composed of CysD, the smaller subunit, and CysN.|||In the C-terminal section; belongs to the APS kinase family.|||In the N-terminal section; belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.|||Proposed to provide activated sulfate for transfer to Nod factor. ATP sulfurylase may be the GTPase, regulating ATP sulfurylase activity.|||Sulfate-activating enzymes, NodP and NodQ, may be physically associated.|||With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD. http://togogenome.org/gene/224914:BME_RS10340 ^@ http://purl.uniprot.org/uniprot/Q8YDZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TrbL/VirB6 family.|||Cell inner membrane http://togogenome.org/gene/224914:BME_RS10995 ^@ http://purl.uniprot.org/uniprot/Q8YDK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliR/MopE/SpaR family.|||Cell membrane|||Membrane|||Role in flagellar biosynthesis. http://togogenome.org/gene/224914:BME_RS07475 ^@ http://purl.uniprot.org/uniprot/Q8YFM3 ^@ Similarity ^@ Belongs to the TlyA family. http://togogenome.org/gene/224914:BME_RS05765 ^@ http://purl.uniprot.org/uniprot/Q8YGK8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 23 kDa subunit family.|||Binds 2 [4Fe-4S] clusters per subunit.|||Cell inner membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/224914:BME_RS01875 ^@ http://purl.uniprot.org/uniprot/Q8YIR2 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/224914:BME_RS07985 ^@ http://purl.uniprot.org/uniprot/Q8YFB8 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/224914:BME_RS14775 ^@ http://purl.uniprot.org/uniprot/Q8YBF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Cell membrane http://togogenome.org/gene/224914:BME_RS03760 ^@ http://purl.uniprot.org/uniprot/Q8YHP4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/224914:BME_RS00925 ^@ http://purl.uniprot.org/uniprot/Q8YJ91 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ClpA/ClpB family.|||Cytoplasm|||Homohexamer. The oligomerization is ATP-dependent (By similarity).|||Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).|||The Clp repeat (R) domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer (By similarity). http://togogenome.org/gene/224914:BME_RS01375 ^@ http://purl.uniprot.org/uniprot/Q8YJ04 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family.|||Cell inner membrane|||Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB). http://togogenome.org/gene/224914:BME_RS09030 ^@ http://purl.uniprot.org/uniprot/Q8YEQ5 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/224914:BME_RS03020 ^@ http://purl.uniprot.org/uniprot/Q8YI40 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Bcr/CmlA family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/224914:BME_RS13270 ^@ http://purl.uniprot.org/uniprot/Q8YCA0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS08620 ^@ http://purl.uniprot.org/uniprot/Q8YEZ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ThiG family.|||Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.|||Cytoplasm|||Homotetramer. Forms heterodimers with either ThiH or ThiS. http://togogenome.org/gene/224914:BME_RS07685 ^@ http://purl.uniprot.org/uniprot/P0A4D9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/224914:BME_RS01610 ^@ http://purl.uniprot.org/uniprot/Q8YIV7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvC family.|||Binds 2 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/224914:BME_RS02550 ^@ http://purl.uniprot.org/uniprot/P64271 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/224914:BME_RS10860 ^@ http://purl.uniprot.org/uniprot/Q8YDN6 ^@ Similarity ^@ Belongs to the HpcH/HpaI aldolase family. http://togogenome.org/gene/224914:BME_RS15315 ^@ http://purl.uniprot.org/uniprot/Q8YB47 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATP phosphoribosyltransferase family. Short subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).|||Cytoplasm|||Heteromultimer composed of HisG and HisZ subunits.|||Lacks the C-terminal regulatory region which is replaced by HisZ. http://togogenome.org/gene/224914:BME_RS12685 ^@ http://purl.uniprot.org/uniprot/Q8YCL7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IlvD/Edd family.|||Binds 1 [4Fe-4S] cluster.|||Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate. http://togogenome.org/gene/224914:BME_RS01265 ^@ http://purl.uniprot.org/uniprot/Q8YJ27 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS10125 ^@ http://purl.uniprot.org/uniprot/P64366 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS01560 ^@ http://purl.uniprot.org/uniprot/P66183 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.|||Binds the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/224914:BME_RS04360 ^@ http://purl.uniprot.org/uniprot/Q8YHC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/224914:BME_RS13870 ^@ http://purl.uniprot.org/uniprot/Q8YBY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Cell membrane http://togogenome.org/gene/224914:BME_RS14135 ^@ http://purl.uniprot.org/uniprot/Q8YBT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/224914:BME_RS14190 ^@ http://purl.uniprot.org/uniprot/Q8YBS0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/224914:BME_RS08225 ^@ http://purl.uniprot.org/uniprot/Q8YF72 ^@ Cofactor|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.|||Binds 2 nickel ions per subunit.|||Carboxylation allows a single lysine to coordinate two nickel ions.|||Cytoplasm|||Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. http://togogenome.org/gene/224914:BME_RS07470 ^@ http://purl.uniprot.org/uniprot/Q8YFM4 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/224914:BME_RS13430 ^@ http://purl.uniprot.org/uniprot/Q8YC70 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS08645 ^@ http://purl.uniprot.org/uniprot/Q8YEY7 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/224914:BME_RS06360 ^@ http://purl.uniprot.org/uniprot/Q8YG97 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS07425 ^@ http://purl.uniprot.org/uniprot/Q8YFN3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS14600 ^@ http://purl.uniprot.org/uniprot/Q8YBK0 ^@ Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 2 family. http://togogenome.org/gene/224914:BME_RS03795 ^@ http://purl.uniprot.org/uniprot/Q8YHN7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/224914:BME_RS02040 ^@ http://purl.uniprot.org/uniprot/Q8YIN4 ^@ Cofactor ^@ Can also use Mn(2+) ion. http://togogenome.org/gene/224914:BME_RS15720 ^@ http://purl.uniprot.org/uniprot/Q8YAW6 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/224914:BME_RS01255 ^@ http://purl.uniprot.org/uniprot/Q8YJ29 ^@ Activity Regulation|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4-hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell mitogen. Plays an important role in the regulation of intra- and extracellular amino acid pools, allowing the bacterium to profit from host precursors and enzymatic pathways.|||Belongs to the proline racemase family.|||Homodimer.|||Inhibited by iodoacetate, iodoacetamide and by high amounts (10 mM) of pyrrole-2-carboxylic acid (PYC). Not inhibited by PYC at 1 mM.|||This enzyme does not require pyridoxal phosphate (PLP) as a cofactor. http://togogenome.org/gene/224914:BME_RS03200 ^@ http://purl.uniprot.org/uniprot/Q8YI02 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UreD family.|||Cytoplasm|||Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.|||UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. http://togogenome.org/gene/224914:BME_RS02880 ^@ http://purl.uniprot.org/uniprot/Q8YI66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family. MurG subfamily.|||Cell inner membrane|||Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II). http://togogenome.org/gene/224914:BME_RS04245 ^@ http://purl.uniprot.org/uniprot/Q8YHF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KdsA family.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS06665 ^@ http://purl.uniprot.org/uniprot/Q8YG38 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/224914:BME_RS02395 ^@ http://purl.uniprot.org/uniprot/Q8YIG5 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/224914:BME_RS06245 ^@ http://purl.uniprot.org/uniprot/Q8YGB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS12660 ^@ http://purl.uniprot.org/uniprot/Q8YCM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Cell membrane http://togogenome.org/gene/224914:BME_RS01815 ^@ http://purl.uniprot.org/uniprot/Q8YIS2 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/224914:BME_RS02890 ^@ http://purl.uniprot.org/uniprot/Q8YI64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurB family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS07545 ^@ http://purl.uniprot.org/uniprot/Q8YFL0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/224914:BME_RS11695 ^@ http://purl.uniprot.org/uniprot/P0A4R0 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MsrP family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).|||Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.|||Periplasm|||Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. http://togogenome.org/gene/224914:BME_RS11955 ^@ http://purl.uniprot.org/uniprot/Q8YD16 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/224914:BME_RS02665 ^@ http://purl.uniprot.org/uniprot/Q8YIB0 ^@ Similarity ^@ Belongs to the UPF0260 family. http://togogenome.org/gene/224914:BME_RS10765 ^@ http://purl.uniprot.org/uniprot/Q8YDQ6 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/224914:BME_RS15485 ^@ http://purl.uniprot.org/uniprot/Q8YB13 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family.|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each. http://togogenome.org/gene/224914:BME_RS10050 ^@ http://purl.uniprot.org/uniprot/Q8YE49 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/224914:BME_RS09085 ^@ http://purl.uniprot.org/uniprot/Q8YEP3 ^@ Similarity ^@ Belongs to the PhzF family. http://togogenome.org/gene/224914:BME_RS14525 ^@ http://purl.uniprot.org/uniprot/Q8YBL4 ^@ Similarity ^@ Belongs to the UPF0423 family. http://togogenome.org/gene/224914:BME_RS07720 ^@ http://purl.uniprot.org/uniprot/Q8YFH3 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/224914:BME_RS13570 ^@ http://purl.uniprot.org/uniprot/Q8YC45 ^@ Similarity ^@ Belongs to the SdhE FAD assembly factor family. http://togogenome.org/gene/224914:BME_RS01325 ^@ http://purl.uniprot.org/uniprot/P66205 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/224914:BME_RS10960 ^@ http://purl.uniprot.org/uniprot/Q8YDL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum|||Belongs to the bacterial flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.|||Secreted http://togogenome.org/gene/224914:BME_RS15445 ^@ http://purl.uniprot.org/uniprot/Q8YB21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliP/MopC/SpaP family.|||Cell membrane|||Membrane|||Plays a role in the flagellum-specific transport system. http://togogenome.org/gene/224914:BME_RS00645 ^@ http://purl.uniprot.org/uniprot/Q8YJE7 ^@ Function|||Similarity ^@ Belongs to the LDH/MDH superfamily. MDH type 3 family.|||Catalyzes the reversible oxidation of malate to oxaloacetate. http://togogenome.org/gene/224914:BME_RS00495 ^@ http://purl.uniprot.org/uniprot/Q8YJH6 ^@ Similarity ^@ Belongs to the asparaginase 1 family. http://togogenome.org/gene/224914:BME_RS08760 ^@ http://purl.uniprot.org/uniprot/Q8YEW2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PAPS reductase family. CysH subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS02800 ^@ http://purl.uniprot.org/uniprot/Q8YI85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69) family.|||Cell membrane|||Membrane http://togogenome.org/gene/224914:BME_RS02635 ^@ http://purl.uniprot.org/uniprot/Q8YIB8 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/224914:BME_RS04430 ^@ http://purl.uniprot.org/uniprot/P65948 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueA family.|||Cytoplasm|||Monomer.|||Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). http://togogenome.org/gene/224914:BME_RS14205 ^@ http://purl.uniprot.org/uniprot/P65447 ^@ Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family. http://togogenome.org/gene/224914:BME_RS15665 ^@ http://purl.uniprot.org/uniprot/Q8YAX7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Homodimer. http://togogenome.org/gene/224914:BME_RS13110 ^@ http://purl.uniprot.org/uniprot/Q8YCD6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS06695 ^@ http://purl.uniprot.org/uniprot/Q8YG32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1C family.|||Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions.|||Periplasm http://togogenome.org/gene/224914:BME_RS06540 ^@ http://purl.uniprot.org/uniprot/Q8YG60 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/224914:BME_RS11895 ^@ http://purl.uniprot.org/uniprot/Q8YD27 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase S12 family.|||Homodimer.|||Hydrolyzes N-terminal residues in D-amino acid-containing peptides.|||Inhibited by beta-lactam compounds such as 6-aminopenicillic acid, 7-aminocephalosporanic acid, benzylpenicillin and ampicillin. Inhibited by p-chloromercuribenzoate. http://togogenome.org/gene/224914:BME_RS00820 ^@ http://purl.uniprot.org/uniprot/Q8YJB3 ^@ Similarity ^@ Belongs to the YciI family. http://togogenome.org/gene/224914:BME_RS15195 ^@ http://purl.uniprot.org/uniprot/Q8YB71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Cell membrane|||Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. http://togogenome.org/gene/224914:BME_RS10320 ^@ http://purl.uniprot.org/uniprot/Q9RPY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PtlA family.|||Cell membrane http://togogenome.org/gene/224914:BME_RS01690 ^@ http://purl.uniprot.org/uniprot/Q8YIU5 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. http://togogenome.org/gene/224914:BME_RS02615 ^@ http://purl.uniprot.org/uniprot/Q8YIC2 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/224914:BME_RS07355 ^@ http://purl.uniprot.org/uniprot/P65217 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/224914:BME_RS04655 ^@ http://purl.uniprot.org/uniprot/Q8YH69 ^@ Function|||Similarity|||Subunit ^@ Belongs to the serine/threonine dehydratase family.|||Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.|||Homotetramer. http://togogenome.org/gene/224914:BME_RS02405 ^@ http://purl.uniprot.org/uniprot/Q8YIG3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/224914:BME_RS13485 ^@ http://purl.uniprot.org/uniprot/Q8YC60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YqgF nuclease family.|||Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS10185 ^@ http://purl.uniprot.org/uniprot/Q8YE20 ^@ Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). http://togogenome.org/gene/224914:BME_RS09725 ^@ http://purl.uniprot.org/uniprot/Q8YEB4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/224914:BME_RS00415 ^@ http://purl.uniprot.org/uniprot/Q8YJJ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS15080 ^@ http://purl.uniprot.org/uniprot/Q8YB94 ^@ Similarity ^@ Belongs to the DapA family. http://togogenome.org/gene/224914:BME_RS15505 ^@ http://purl.uniprot.org/uniprot/Q8YB09 ^@ Similarity ^@ Belongs to the hyi family. http://togogenome.org/gene/224914:BME_RS14865 ^@ http://purl.uniprot.org/uniprot/Q8YBD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Cell membrane http://togogenome.org/gene/224914:BME_RS11610 ^@ http://purl.uniprot.org/uniprot/Q8YD88 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/224914:BME_RS04115 ^@ http://purl.uniprot.org/uniprot/P64048 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS09745 ^@ http://purl.uniprot.org/uniprot/P67212 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RimP family.|||Cytoplasm|||Required for maturation of 30S ribosomal subunits. http://togogenome.org/gene/224914:BME_RS01015 ^@ http://purl.uniprot.org/uniprot/Q8YJ80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/224914:BME_RS05940 ^@ http://purl.uniprot.org/uniprot/Q8YGH9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/224914:BME_RS01170 ^@ http://purl.uniprot.org/uniprot/Q8YJ48 ^@ Function|||PTM|||Similarity ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.|||Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. http://togogenome.org/gene/224914:BME_RS06075 ^@ http://purl.uniprot.org/uniprot/Q8YGF1 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/224914:BME_RS05985 ^@ http://purl.uniprot.org/uniprot/Q8YGH0 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion.|||Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.|||In the C-terminal section; belongs to the HTP reductase family.|||In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/224914:BME_RS13465 ^@ http://purl.uniprot.org/uniprot/Q8YC64 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsY family.|||Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.|||Cell inner membrane|||Probably interacts with PlsX. http://togogenome.org/gene/224914:BME_RS02565 ^@ http://purl.uniprot.org/uniprot/Q8YID3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TrkH potassium transport family.|||Cell inner membrane|||Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.|||Membrane http://togogenome.org/gene/224914:BME_RS01230 ^@ http://purl.uniprot.org/uniprot/Q8YJ35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/224914:BME_RS10475 ^@ http://purl.uniprot.org/uniprot/Q8YDW4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 1 lipoyl cofactor covalently.|||Forms a 24-polypeptide structural core with octahedral symmetry.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/224914:BME_RS09410 ^@ http://purl.uniprot.org/uniprot/Q8YEH9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Cell membrane|||Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.|||Heterooctamer of two A chains, two B chains, two C chains and two D chains.|||Membrane http://togogenome.org/gene/224914:BME_RS01300 ^@ http://purl.uniprot.org/uniprot/Q8YJ19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS03075 ^@ http://purl.uniprot.org/uniprot/Q8YI28 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/224914:BME_RS04665 ^@ http://purl.uniprot.org/uniprot/Q8YH68 ^@ Cofactor|||Similarity ^@ Belongs to the WrbA family.|||Binds 1 FMN per monomer. http://togogenome.org/gene/224914:BME_RS05655 ^@ http://purl.uniprot.org/uniprot/Q8YGN0 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/224914:BME_RS00570 ^@ http://purl.uniprot.org/uniprot/Q8YJG2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell inner membrane|||Cytoplasm|||May bind 1 zinc ion per subunit.|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/224914:BME_RS12695 ^@ http://purl.uniprot.org/uniprot/Q8YCL5 ^@ Caution|||Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/224914:BME_RS14825 ^@ http://purl.uniprot.org/uniprot/Q8YBE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PpiC/parvulin rotamase family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/224914:BME_RS01040 ^@ http://purl.uniprot.org/uniprot/P67516 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase RlmH family.|||Cytoplasm|||Homodimer.|||Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. http://togogenome.org/gene/224914:BME_RS14395 ^@ http://purl.uniprot.org/uniprot/Q8YBN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for the translocation of the substrate across the membrane (By similarity).|||The complex is composed of two ATP-binding proteins (BMEII0863 and BMEII0864), two transmembrane proteins (BMEII0860 and BMEII0861) and a solute-binding protein (BMEII0859). http://togogenome.org/gene/224914:BME_RS05580 ^@ http://purl.uniprot.org/uniprot/Q8YGP5 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/224914:BME_RS10945 ^@ http://purl.uniprot.org/uniprot/Q8YDL7 ^@ Caution|||Disruption Phenotype|||Function|||Miscellaneous ^@ Inactivation of the ftcR gene down-regulates the activity of the fliF promoter region and the production of both flgE and fliC proteins during vegetative growth or during macrophage infection. This mutant also lacks the flagellar structures under growth conditions in which the wild-type strain is flagellated. The mutant is not attenuated in cellular infection models but exhibits a marked virulence defect after 4 weeks or more of infection in mice.|||Lacks the conserved Asp residue in position 50 usually required for phosphorylation. The Glu residue in position 50 may mimic constitutive phosphorylation and allow FtcR to bypass the requirement for phosphorylation.|||Required for transcription of the fliF gene during vegetative and intracellular growth and for production of the two flagellar components flgE and fliC during vegetative growth. Specifically binds to the fliF promoter region. Could mediate the action of VjbR on flagellar gene expression.|||There is no cognate histidine kinase partner identified so far for FtcR. http://togogenome.org/gene/224914:BME_RS11410 ^@ http://purl.uniprot.org/uniprot/Q8YDC8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DapB family.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.|||Cytoplasm|||Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. http://togogenome.org/gene/224914:BME_RS03965 ^@ http://purl.uniprot.org/uniprot/P63631 ^@ Function|||Similarity ^@ Belongs to the aspartate/glutamate racemases family.|||Provides the (R)-glutamate required for cell wall biosynthesis. http://togogenome.org/gene/224914:BME_RS10705 ^@ http://purl.uniprot.org/uniprot/Q8YDR8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Probably part of an ABC transporter complex. Probably responsible for the translocation of the substrate across the membrane (Probable).|||The complex is composed of two ATP-binding proteins (BMEII0108), two transmembrane proteins (BMEII0107) and a solute-binding protein (BMEII0109). http://togogenome.org/gene/224914:BME_RS10395 ^@ http://purl.uniprot.org/uniprot/Q8YDY3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the threonine aldolase family.|||Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde.|||Homotetramer. http://togogenome.org/gene/224914:BME_RS03840 ^@ http://purl.uniprot.org/uniprot/Q8YHM8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/224914:BME_RS11850 ^@ http://purl.uniprot.org/uniprot/Q8YD36 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS01295 ^@ http://purl.uniprot.org/uniprot/Q8YJ20 ^@ Function ^@ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. http://togogenome.org/gene/224914:BME_RS08290 ^@ http://purl.uniprot.org/uniprot/P65452 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS04215 ^@ http://purl.uniprot.org/uniprot/Q8YHF7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer. http://togogenome.org/gene/224914:BME_RS04140 ^@ http://purl.uniprot.org/uniprot/Q8YHH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Cell inner membrane http://togogenome.org/gene/224914:BME_RS06375 ^@ http://purl.uniprot.org/uniprot/P65680 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PdxA family.|||Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).|||Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).|||Cytoplasm|||Homodimer.|||The active site is located at the dimer interface. http://togogenome.org/gene/224914:BME_RS05420 ^@ http://purl.uniprot.org/uniprot/P66879 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/224914:BME_RS00900 ^@ http://purl.uniprot.org/uniprot/Q8YJ97 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/224914:BME_RS13415 ^@ http://purl.uniprot.org/uniprot/Q8YC73 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Essential protein that is involved in the control of cell division, probably through the regulation of ctrA. Its phosphorylation status is regulated by PdhS (By similarity).|||Interacts with DivL, PleC, DivJ and PdhS. http://togogenome.org/gene/224914:BME_RS11605 ^@ http://purl.uniprot.org/uniprot/Q8YD89 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system. http://togogenome.org/gene/224914:BME_RS03045 ^@ http://purl.uniprot.org/uniprot/Q8YI34 ^@ Function|||Similarity ^@ Belongs to the band 7/mec-2 family. HflC subfamily.|||HflC and HflK could regulate a protease. http://togogenome.org/gene/224914:BME_RS03175 ^@ http://purl.uniprot.org/uniprot/Q8YI08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CbiQ family.|||Membrane http://togogenome.org/gene/224914:BME_RS03790 ^@ http://purl.uniprot.org/uniprot/Q8YHN8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/224914:BME_RS07350 ^@ http://purl.uniprot.org/uniprot/Q8YFQ2 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/224914:BME_RS08965 ^@ http://purl.uniprot.org/uniprot/Q8YER8 ^@ Similarity ^@ Belongs to the YkuD family. http://togogenome.org/gene/224914:BME_RS11960 ^@ http://purl.uniprot.org/uniprot/Q8YD15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.|||Membrane|||Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/224914:BME_RS12090 ^@ http://purl.uniprot.org/uniprot/Q8YCY9 ^@ Similarity|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/224914:BME_RS11025 ^@ http://purl.uniprot.org/uniprot/Q8YDK0 ^@ Cofactor|||Similarity ^@ Belongs to the Fur family.|||Binds 1 Mn(2+) or Fe(2+) ion per subunit.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/224914:BME_RS09170 ^@ http://purl.uniprot.org/uniprot/Q8YEM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmB/CycW/HelB family.|||Cell inner membrane|||Membrane|||Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. http://togogenome.org/gene/224914:BME_RS07100 ^@ http://purl.uniprot.org/uniprot/F8WJX9 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/224914:BME_RS11810 ^@ http://purl.uniprot.org/uniprot/P66514 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/224914:BME_RS14500 ^@ http://purl.uniprot.org/uniprot/Q8YBL9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/224914:BME_RS01625 ^@ http://purl.uniprot.org/uniprot/Q8YIV4 ^@ Similarity ^@ Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. http://togogenome.org/gene/224914:BME_RS09835 ^@ http://purl.uniprot.org/uniprot/P63361 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.|||Cell inner membrane|||Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS). http://togogenome.org/gene/224914:BME_RS02065 ^@ http://purl.uniprot.org/uniprot/Q8YIN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Cell membrane http://togogenome.org/gene/224914:BME_RS12210 ^@ http://purl.uniprot.org/uniprot/P65275 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 1 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/224914:BME_RS11460 ^@ http://purl.uniprot.org/uniprot/Q8YDB8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell inner membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/224914:BME_RS04270 ^@ http://purl.uniprot.org/uniprot/Q8YHE6 ^@ Function|||Subunit ^@ Heterodimer of an alpha and a beta chain.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/224914:BME_RS15490 ^@ http://purl.uniprot.org/uniprot/Q8YB12 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family.|||Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.|||The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod. http://togogenome.org/gene/224914:BME_RS11975 ^@ http://purl.uniprot.org/uniprot/Q8YD12 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the urocanase family.|||Binds 1 NAD(+) per subunit.|||Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS06495 ^@ http://purl.uniprot.org/uniprot/Q8YG69 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS05780 ^@ http://purl.uniprot.org/uniprot/Q8YGK5 ^@ Function|||Similarity ^@ Belongs to the complex I 51 kDa subunit family.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. http://togogenome.org/gene/224914:BME_RS05875 ^@ http://purl.uniprot.org/uniprot/Q8YGJ0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/224914:BME_RS12080 ^@ http://purl.uniprot.org/uniprot/Q8YCZ1 ^@ Similarity ^@ Belongs to the UPF0309 family. http://togogenome.org/gene/224914:BME_RS00700 ^@ http://purl.uniprot.org/uniprot/P66651 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.|||Belongs to the RimM family.|||Binds ribosomal protein uS19.|||Cytoplasm|||The PRC barrel domain binds ribosomal protein uS19. http://togogenome.org/gene/224914:BME_RS00165 ^@ http://purl.uniprot.org/uniprot/Q8YJP5 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/224914:BME_RS03765 ^@ http://purl.uniprot.org/uniprot/Q8YHP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS13500 ^@ http://purl.uniprot.org/uniprot/Q8YC57 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/224914:BME_RS10350 ^@ http://purl.uniprot.org/uniprot/Q9RPX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the virB8 family.|||Cell inner membrane http://togogenome.org/gene/224914:BME_RS07370 ^@ http://purl.uniprot.org/uniprot/Q8YFP7 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/224914:BME_RS01580 ^@ http://purl.uniprot.org/uniprot/Q8YIW3 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/224914:BME_RS06260 ^@ http://purl.uniprot.org/uniprot/Q8YGB6 ^@ Similarity ^@ Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. http://togogenome.org/gene/224914:BME_RS07700 ^@ http://purl.uniprot.org/uniprot/F8WJP7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase C chain family.|||Cell inner membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.|||Membrane http://togogenome.org/gene/224914:BME_RS10885 ^@ http://purl.uniprot.org/uniprot/Q8YDN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Xylose importer (TC 3.A.1.2.4) family.|||Cell inner membrane|||Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (XylG), two transmembrane proteins (XylH) and a solute-binding protein (XylF). http://togogenome.org/gene/224914:BME_RS13810 ^@ http://purl.uniprot.org/uniprot/F8WJP0 ^@ Cofactor ^@ Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/224914:BME_RS12310 ^@ http://purl.uniprot.org/uniprot/Q8YCU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS07390 ^@ http://purl.uniprot.org/uniprot/Q8YFP0 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with bS18 to 16S ribosomal RNA. http://togogenome.org/gene/224914:BME_RS04540 ^@ http://purl.uniprot.org/uniprot/Q8YH92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell inner membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/224914:BME_RS03770 ^@ http://purl.uniprot.org/uniprot/P64024 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/224914:BME_RS13475 ^@ http://purl.uniprot.org/uniprot/P65611 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. http://togogenome.org/gene/224914:BME_RS15070 ^@ http://purl.uniprot.org/uniprot/Q8YB97 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS10195 ^@ http://purl.uniprot.org/uniprot/P67193 ^@ Function|||Similarity ^@ Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.|||Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. http://togogenome.org/gene/224914:BME_RS15325 ^@ http://purl.uniprot.org/uniprot/Q8YB45 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/224914:BME_RS08780 ^@ http://purl.uniprot.org/uniprot/P67228 ^@ Similarity ^@ Belongs to the UPF0102 family. http://togogenome.org/gene/224914:BME_RS10105 ^@ http://purl.uniprot.org/uniprot/Q8YE37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). http://togogenome.org/gene/224914:BME_RS00685 ^@ http://purl.uniprot.org/uniprot/Q8YJE1 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/224914:BME_RS12270 ^@ http://purl.uniprot.org/uniprot/Q8YCV3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Catalyzes the isomerization of D-erythrulose-4P to L-erythrulose-1P.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/224914:BME_RS13075 ^@ http://purl.uniprot.org/uniprot/Q8YCE3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FdhD family.|||Cytoplasm|||Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. http://togogenome.org/gene/224914:BME_RS03775 ^@ http://purl.uniprot.org/uniprot/P66324 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/224914:BME_RS03905 ^@ http://purl.uniprot.org/uniprot/Q8YHL5 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/224914:BME_RS06945 ^@ http://purl.uniprot.org/uniprot/Q8YFY3 ^@ Function ^@ Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity). http://togogenome.org/gene/224914:BME_RS09270 ^@ http://purl.uniprot.org/uniprot/Q8YEK8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/224914:BME_RS09845 ^@ http://purl.uniprot.org/uniprot/Q8YE90 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell inner membrane|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/224914:BME_RS09110 ^@ http://purl.uniprot.org/uniprot/Q8YEN8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.|||Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.|||The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP). http://togogenome.org/gene/224914:BME_RS11710 ^@ http://purl.uniprot.org/uniprot/Q8YD69 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily. http://togogenome.org/gene/224914:BME_RS00830 ^@ http://purl.uniprot.org/uniprot/Q8YJB1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. http://togogenome.org/gene/224914:BME_RS07420 ^@ http://purl.uniprot.org/uniprot/Q8YFN4 ^@ Domain|||Function|||Similarity ^@ Belongs to the RecA family. RadA subfamily.|||DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.|||Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.|||The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. http://togogenome.org/gene/224914:BME_RS05310 ^@ http://purl.uniprot.org/uniprot/Q8YGU6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type-II 3-dehydroquinase family.|||Catalyzes a trans-dehydration via an enolate intermediate.|||Homododecamer. http://togogenome.org/gene/224914:BME_RS04155 ^@ http://purl.uniprot.org/uniprot/Q8YHG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thioester dehydratase family. FabZ subfamily.|||Cytoplasm|||Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity). http://togogenome.org/gene/224914:BME_RS07710 ^@ http://purl.uniprot.org/uniprot/Q8YFH5 ^@ Function|||Similarity ^@ A possible function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex.|||Belongs to the bacterial AtpI family. http://togogenome.org/gene/224914:BME_RS09840 ^@ http://purl.uniprot.org/uniprot/Q8YE91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell inner membrane|||Membrane http://togogenome.org/gene/224914:BME_RS07630 ^@ http://purl.uniprot.org/uniprot/Q8YFJ0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/224914:BME_RS09785 ^@ http://purl.uniprot.org/uniprot/Q8YEA2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methylthiotransferase family. MiaB subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.|||Cytoplasm|||Monomer. http://togogenome.org/gene/224914:BME_RS03620 ^@ http://purl.uniprot.org/uniprot/Q8YHR8 ^@ Similarity ^@ Belongs to the RecJ family. http://togogenome.org/gene/224914:BME_RS07705 ^@ http://purl.uniprot.org/uniprot/Q8YFH6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase A chain family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. http://togogenome.org/gene/224914:BME_RS04210 ^@ http://purl.uniprot.org/uniprot/P66988 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/224914:BME_RS00815 ^@ http://purl.uniprot.org/uniprot/Q8YJB4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/224914:BME_RS08070 ^@ http://purl.uniprot.org/uniprot/Q8YFA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm|||Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. http://togogenome.org/gene/224914:BME_RS13280 ^@ http://purl.uniprot.org/uniprot/Q8YC98 ^@ Similarity ^@ Belongs to the class-II fumarase/aspartase family. http://togogenome.org/gene/224914:BME_RS14785 ^@ http://purl.uniprot.org/uniprot/Q8YBF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 1 family.|||Periplasm http://togogenome.org/gene/224914:BME_RS13625 ^@ http://purl.uniprot.org/uniprot/Q8YC34 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/224914:BME_RS00020 ^@ http://purl.uniprot.org/uniprot/Q8YJS9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Rho family.|||Cell inner membrane|||Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.|||Homohexamer. The homohexamer assembles into an open ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/224914:BME_RS00195 ^@ http://purl.uniprot.org/uniprot/P63615 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.|||Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).|||Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).|||Cytoplasm http://togogenome.org/gene/224914:BME_RS09225 ^@ http://purl.uniprot.org/uniprot/Q8YEL6 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/224914:BME_RS04170 ^@ http://purl.uniprot.org/uniprot/Q8YHG6 ^@ Function|||Similarity ^@ Belongs to the LpxB family.|||Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. http://togogenome.org/gene/224914:BME_RS13020 ^@ http://purl.uniprot.org/uniprot/Q8YCF1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS11865 ^@ http://purl.uniprot.org/uniprot/Q8YD33 ^@ Function ^@ Component of an amino-acid transport system. http://togogenome.org/gene/224914:BME_RS12180 ^@ http://purl.uniprot.org/uniprot/Q8YCX3 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/224914:BME_RS02875 ^@ http://purl.uniprot.org/uniprot/Q8YI67 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS12875 ^@ http://purl.uniprot.org/uniprot/Q8YCH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Cell membrane http://togogenome.org/gene/224914:BME_RS02380 ^@ http://purl.uniprot.org/uniprot/P63542 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/224914:BME_RS05680 ^@ http://purl.uniprot.org/uniprot/Q8YGM5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/224914:BME_RS14855 ^@ http://purl.uniprot.org/uniprot/Q8YBE0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase U32 family. UbiV subfamily.|||Forms an heterodimer with UbiU.|||Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiU, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway. http://togogenome.org/gene/224914:BME_RS00895 ^@ http://purl.uniprot.org/uniprot/Q8YJ98 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. UbiG/COQ3 family.|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/224914:BME_RS04395 ^@ http://purl.uniprot.org/uniprot/Q8YHC0 ^@ Function|||Similarity ^@ Belongs to the ribose 1,5-bisphosphokinase family.|||Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). http://togogenome.org/gene/224914:BME_RS04075 ^@ http://purl.uniprot.org/uniprot/Q9K5F1 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/224914:BME_RS10280 ^@ http://purl.uniprot.org/uniprot/P0A3D6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Catalyzes the ferrous insertion into protoporphyrin IX.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS00175 ^@ http://purl.uniprot.org/uniprot/Q8YJP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccA family.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS07655 ^@ http://purl.uniprot.org/uniprot/Q8YFI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Cell inner membrane|||In the C-terminal section; belongs to the peptidase S49 family.|||In the N-terminal section; belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.|||Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. http://togogenome.org/gene/224914:BME_RS05635 ^@ http://purl.uniprot.org/uniprot/Q8YGN4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/224914:BME_RS13185 ^@ http://purl.uniprot.org/uniprot/Q8YCC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/224914:BME_RS06975 ^@ http://purl.uniprot.org/uniprot/Q8YFX6 ^@ Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate. http://togogenome.org/gene/224914:BME_RS10190 ^@ http://purl.uniprot.org/uniprot/Q8YE19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family. YceF subfamily.|||Cytoplasm|||Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/224914:BME_RS13525 ^@ http://purl.uniprot.org/uniprot/Q8YC53 ^@ Function|||Induction|||PTM ^@ FMN binds covalently to cysteine after exposure to blue light and this bond is spontaneously broken in the dark. However, this protein presents an adduct state that is extremely and unusually stable and does not decay measurably in 2h.|||Induced after invasion of host macrophages.|||Photosensitive kinase that is involved in increased bacterial virulence upon exposure to light. Once ejected from an infected animal host, sunlight acts as an environmental signal that increases the virulence of the bacterium, preparing it for infection of the next host. This photoreceptor protein is directly related to the bacterium's survival and replication within host macrophages. http://togogenome.org/gene/224914:BME_RS00320 ^@ http://purl.uniprot.org/uniprot/Q8YJL1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Homodimer. Forms a membrane-associated complex with FtsX.|||Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring. http://togogenome.org/gene/224914:BME_RS04815 ^@ http://purl.uniprot.org/uniprot/Q8YH37 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.|||In the N-terminal section; belongs to the malic enzymes family. http://togogenome.org/gene/224914:BME_RS11180 ^@ http://purl.uniprot.org/uniprot/Q8YDH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Cell membrane http://togogenome.org/gene/224914:BME_RS02445 ^@ http://purl.uniprot.org/uniprot/Q8YIF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell inner membrane http://togogenome.org/gene/224914:BME_RS08510 ^@ http://purl.uniprot.org/uniprot/Q8YF14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Membrane http://togogenome.org/gene/224914:BME_RS03720 ^@ http://purl.uniprot.org/uniprot/Q8YHQ1 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/224914:BME_RS00635 ^@ http://purl.uniprot.org/uniprot/P0A3P1 ^@ Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the rhizobiaceae omp19 lipoprotein family.|||Cell outer membrane|||Elicits an immune response in humans, mice, sheep and goats infected with B.melitensis or B.abortus, but not in B.abortus-infected cattle. http://togogenome.org/gene/224914:BME_RS01620 ^@ http://purl.uniprot.org/uniprot/Q8YIV5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvB family.|||Cytoplasm|||Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.|||Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA. http://togogenome.org/gene/224914:BME_RS02415 ^@ http://purl.uniprot.org/uniprot/Q8YIG1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/224914:BME_RS09235 ^@ http://purl.uniprot.org/uniprot/P65722 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/224914:BME_RS04385 ^@ http://purl.uniprot.org/uniprot/Q8YHC2 ^@ Function|||Subunit ^@ Homotetramer.|||Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. http://togogenome.org/gene/224914:BME_RS08300 ^@ http://purl.uniprot.org/uniprot/Q8YF59 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. http://togogenome.org/gene/224914:BME_RS10640 ^@ http://purl.uniprot.org/uniprot/Q8YDT3 ^@ Similarity ^@ Belongs to the ParB family. http://togogenome.org/gene/224914:BME_RS10135 ^@ http://purl.uniprot.org/uniprot/Q8YE30 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.|||Belongs to the ClpX chaperone family. HslU subfamily.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS12170 ^@ http://purl.uniprot.org/uniprot/Q8YCX5 ^@ Similarity ^@ Belongs to the UPF0434 family. http://togogenome.org/gene/224914:BME_RS15285 ^@ http://purl.uniprot.org/uniprot/Q8YB53 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/224914:BME_RS05785 ^@ http://purl.uniprot.org/uniprot/Q8YGK4 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/224914:BME_RS01645 ^@ http://purl.uniprot.org/uniprot/Q93TG4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TolB family.|||Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.|||Periplasm|||The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer. http://togogenome.org/gene/224914:BME_RS05465 ^@ http://purl.uniprot.org/uniprot/Q8YGR9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/224914:BME_RS15350 ^@ http://purl.uniprot.org/uniprot/Q8YB40 ^@ Cofactor|||Function ^@ Binds 2 [4Fe-4S] clusters.|||Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. http://togogenome.org/gene/224914:BME_RS03485 ^@ http://purl.uniprot.org/uniprot/Q8YHU3 ^@ Function|||Similarity ^@ Belongs to the CbiD family.|||Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. http://togogenome.org/gene/224914:BME_RS04180 ^@ http://purl.uniprot.org/uniprot/Q8YHG4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Monomer. http://togogenome.org/gene/224914:BME_RS04750 ^@ http://purl.uniprot.org/uniprot/Q8YH49 ^@ Function|||Similarity ^@ Belongs to the DHNA family.|||Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. http://togogenome.org/gene/224914:BME_RS10910 ^@ http://purl.uniprot.org/uniprot/Q8YDM5 ^@ Caution|||Disruption Phenotype|||Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ A fliC mutant is attenuated in a murine model of infection. As the infection progresses, the number of cfu per spleen from mice infected with the mutant is significantly lower than the number from mice infected with the wild-type.|||Bacterial flagellum|||Belongs to the bacterial flagellin family.|||Despite the presence of a stop codon in position 243 in the fliF gene and in position 127 in the flhA gene, it has been shown that B.melitensis is able to express genes corresponding to the M ring, the hook and the filament of the flagellar apparatus in the early log phase of growth in 2YT broth. Under these conditions, a polar and sheathed flagellar structure is visible by transmission electron microscopy.|||Expressed at the onset of the exponential phase (after 4, 8 and 12 hours of culture) but not at later time points.|||Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella (By similarity). The flagellum is required to cause a persistent disease in a murine model of infection.|||Secreted http://togogenome.org/gene/224914:BME_RS02575 ^@ http://purl.uniprot.org/uniprot/Q8YID1 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/224914:BME_RS00825 ^@ http://purl.uniprot.org/uniprot/P64186 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS03940 ^@ http://purl.uniprot.org/uniprot/Q8YHK7 ^@ Cofactor|||Similarity ^@ Belongs to the alkaline phosphatase family.|||Binds 1 Mg(2+) ion.|||Binds 2 Zn(2+) ions. http://togogenome.org/gene/224914:BME_RS13560 ^@ http://purl.uniprot.org/uniprot/Q8YC47 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/224914:BME_RS12555 ^@ http://purl.uniprot.org/uniprot/Q8YCP2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transcriptional regulatory CopG/NikR family.|||Binds 1 nickel ion per subunit.|||Homotetramer.|||Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel (By similarity). http://togogenome.org/gene/224914:BME_RS03970 ^@ http://purl.uniprot.org/uniprot/P0A3T2 ^@ Miscellaneous ^@ Brucella abortus is the causative agent for brucellosis in cattle and man. http://togogenome.org/gene/224914:BME_RS14000 ^@ http://purl.uniprot.org/uniprot/Q8YBV7 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. BioZ family.|||Involved in the formation of the biotin precursor pimeloyl-ACP. Catalyzes the condensation of glutaryl-CoA, an intermediate in lysine degradation, with malonyl-ACP to produce 3-oxopimeloyl-ACP. http://togogenome.org/gene/224914:BME_RS11510 ^@ http://purl.uniprot.org/uniprot/Q8YDA8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transferase hexapeptide repeat family.|||Cytoplasm|||Homotrimer. http://togogenome.org/gene/224914:BME_RS11600 ^@ http://purl.uniprot.org/uniprot/Q8YD90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system. http://togogenome.org/gene/224914:BME_RS01055 ^@ http://purl.uniprot.org/uniprot/Q8YJ72 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/224914:BME_RS08790 ^@ http://purl.uniprot.org/uniprot/Q8YEV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||Cytoplasm|||Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/224914:BME_RS03540 ^@ http://purl.uniprot.org/uniprot/Q8YHT3 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/224914:BME_RS06030 ^@ http://purl.uniprot.org/uniprot/P63646 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the R-transferase family. Bpt subfamily.|||Cytoplasm|||Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate. http://togogenome.org/gene/224914:BME_RS10360 ^@ http://purl.uniprot.org/uniprot/Q8YDZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TrbI/VirB10 family.|||Cell membrane http://togogenome.org/gene/224914:BME_RS13495 ^@ http://purl.uniprot.org/uniprot/P64203 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/224914:BME_RS06200 ^@ http://purl.uniprot.org/uniprot/Q8YGC8 ^@ Function ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. http://togogenome.org/gene/224914:BME_RS04920 ^@ http://purl.uniprot.org/uniprot/Q8YH17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.|||Cytoplasm|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.|||Monomer. http://togogenome.org/gene/224914:BME_RS03845 ^@ http://purl.uniprot.org/uniprot/P66399 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/224914:BME_RS08670 ^@ http://purl.uniprot.org/uniprot/Q8YEY0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/224914:BME_RS07380 ^@ http://purl.uniprot.org/uniprot/Q8YFP3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.|||Homotetramer. http://togogenome.org/gene/224914:BME_RS01380 ^@ http://purl.uniprot.org/uniprot/Q8YJ03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell inner membrane|||Part of the ABC transporter complex ThiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate across the membrane.|||The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB). http://togogenome.org/gene/224914:BME_RS05530 ^@ http://purl.uniprot.org/uniprot/Q8YGQ5 ^@ Caution|||Function|||Similarity ^@ Belongs to the Dus family. DusA subfamily.|||Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/224914:BME_RS04145 ^@ http://purl.uniprot.org/uniprot/Q8YHH0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BamA family.|||Cell outer membrane|||Part of the Bam complex.|||Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. http://togogenome.org/gene/224914:BME_RS04935 ^@ http://purl.uniprot.org/uniprot/Q8YH14 ^@ Function|||Similarity ^@ Belongs to the peptidase S11 family.|||Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. http://togogenome.org/gene/224914:BME_RS06575 ^@ http://purl.uniprot.org/uniprot/Q7CNU3 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alphaproteobacteria porin family.|||Cell outer membrane|||Consists of 16-stranded beta-barrel sheets, with large surface-exposed loops, that form a transmembrane pore at the center of each barrel. The pore is partially ocluded by a peptide loop that folds into the pore lumen.|||Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.|||Monomer.|||The pore formed by Omp2a is larger than the one formed by Omp2b. Omp2b pores have optimal permeability to allow growth and protection against harmful compounds. The larger pore formed by Omp2a may be advantageous for intracellular growth, when the bacterium is competing with the host cell for nutrients whose concentration is particularly low within the phagosome. http://togogenome.org/gene/224914:BME_RS05345 ^@ http://purl.uniprot.org/uniprot/P64197 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/224914:BME_RS11450 ^@ http://purl.uniprot.org/uniprot/P67384 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell inner membrane http://togogenome.org/gene/224914:BME_RS12260 ^@ http://purl.uniprot.org/uniprot/Q8YCV5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the class II fructose-bisphosphate aldolase family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.|||Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.|||One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/224914:BME_RS09635 ^@ http://purl.uniprot.org/uniprot/Q8YED2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the FPG family.|||Binds 1 zinc ion per subunit.|||Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.|||Monomer. http://togogenome.org/gene/224914:BME_RS04160 ^@ http://purl.uniprot.org/uniprot/P65320 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transferase hexapeptide repeat family. LpxA subfamily.|||Cytoplasm|||Homotrimer.|||Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. http://togogenome.org/gene/224914:BME_RS15030 ^@ http://purl.uniprot.org/uniprot/Q8YBA4 ^@ Function ^@ Part of the operon norEFCBQD encoding nitric oxide reductase. Essential virulence factor, probably involved in the detoxification of nitric oxide (NO) produced in the macrophages during the innate response against infection (By similarity). http://togogenome.org/gene/224914:BME_RS03355 ^@ http://purl.uniprot.org/uniprot/Q8YHW8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS07935 ^@ http://purl.uniprot.org/uniprot/P65654 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/224914:BME_RS00580 ^@ http://purl.uniprot.org/uniprot/Q8YJG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PpiC/parvulin rotamase family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/224914:BME_RS06520 ^@ http://purl.uniprot.org/uniprot/Q8YG64 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase subunit omega family.|||Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/224914:BME_RS10215 ^@ http://purl.uniprot.org/uniprot/Q8YE15 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family.|||Cell inner membrane|||Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (ModC), two transmembrane proteins (ModB) and a solute-binding protein (ModA). http://togogenome.org/gene/224914:BME_RS13005 ^@ http://purl.uniprot.org/uniprot/Q8YCF4 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/224914:BME_RS07520 ^@ http://purl.uniprot.org/uniprot/P63607 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Homotetramer.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/224914:BME_RS08075 ^@ http://purl.uniprot.org/uniprot/P63566 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/224914:BME_RS05770 ^@ http://purl.uniprot.org/uniprot/Q8YGK7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 1 family.|||Cell inner membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. http://togogenome.org/gene/224914:BME_RS06415 ^@ http://purl.uniprot.org/uniprot/Q8YG86 ^@ Similarity ^@ Belongs to the SOS response-associated peptidase family. http://togogenome.org/gene/224914:BME_RS03340 ^@ http://purl.uniprot.org/uniprot/Q8YHX1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cell inner membrane|||Membrane|||Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.|||The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP). http://togogenome.org/gene/224914:BME_RS09990 ^@ http://purl.uniprot.org/uniprot/P67003 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/224914:BME_RS11965 ^@ http://purl.uniprot.org/uniprot/Q8YD14 ^@ Function ^@ Acts on leucine, isoleucine and valine. http://togogenome.org/gene/224914:BME_RS04875 ^@ http://purl.uniprot.org/uniprot/Q8YH26 ^@ Function|||Similarity|||Subunit ^@ Belongs to the P(II) protein family.|||Homotrimer.|||In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP. P-II-UMP allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme. Conversely, in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP, these events are reversed. http://togogenome.org/gene/224914:BME_RS10880 ^@ http://purl.uniprot.org/uniprot/Q8YDN1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS01750 ^@ http://purl.uniprot.org/uniprot/Q8YIT3 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/224914:BME_RS05105 ^@ http://purl.uniprot.org/uniprot/Q8YGY5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MobA family.|||Cytoplasm|||Monomer.|||The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.|||Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. http://togogenome.org/gene/224914:BME_RS03205 ^@ http://purl.uniprot.org/uniprot/Q8YI01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.|||Cytoplasm|||Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.|||Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. http://togogenome.org/gene/224914:BME_RS15050 ^@ http://purl.uniprot.org/uniprot/Q8YBA0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS03100 ^@ http://purl.uniprot.org/uniprot/Q8YI23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAK/KUP transporter (TC 2.A.72) family.|||Cell inner membrane|||Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter. http://togogenome.org/gene/224914:BME_RS05155 ^@ http://purl.uniprot.org/uniprot/Q8YGX5 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/224914:BME_RS15625 ^@ http://purl.uniprot.org/uniprot/Q8YAY5 ^@ Disruption Phenotype|||Function|||Miscellaneous ^@ As bacterial aggregation is one of the initial steps of biofilm formation, the clumping phenotype observed in the vjbR mutant suggests that B.melitensis might be able to form biofilms.|||Cells show down-regulated expression of both virB operon and flagellar genes either during culture in bacteriological medium or during intracellular infection. They also show no flgE or fliC production between the end of the latent phase of growth and the beginning of the exponential phase. The vjbR mutant is also strongly attenuated in a mouse model of infection, probably because it is defective in intracellular survival. When cultures reach high density, cells aggregate and form clumps. The mutant is able to produce EPS containing alpha-mannopyranosyl and/or alpha-glucopyranosyl residues as well as a beta-linked glucan that seem to be a component of the extracellular matrix of the aggregates.|||Transcriptional regulator involved in the global control of Brucella gene expression. Mediates the effects of the quorum sensing autoinducer C12-HSL (N-dodecanoyl-homoserine lactone) on a large and diverse number of genes, including the virB operon and the flagellar genes fliF and flgE, which are activated in the absence of C12-HSL. Regulates virulence factors as well as several membrane structures. Implicated in the control of outer membrane composition. Plays a role in the expression of genes involved in the EPS synthesis and/or export. Mediates the inhibitory effect of C12-HSL on B.melitensis intracellular replication. Could activate expression of ftcR. http://togogenome.org/gene/224914:BME_RS02060 ^@ http://purl.uniprot.org/uniprot/Q8YIN1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.|||Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD). http://togogenome.org/gene/224914:BME_RS06085 ^@ http://purl.uniprot.org/uniprot/Q8YGE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.|||Cell inner membrane|||Cell membrane|||Membrane http://togogenome.org/gene/224914:BME_RS04065 ^@ http://purl.uniprot.org/uniprot/Q8YHI4 ^@ Similarity ^@ Belongs to the peptidase S11 family. http://togogenome.org/gene/224914:BME_RS01435 ^@ http://purl.uniprot.org/uniprot/P52559 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Homodimer. http://togogenome.org/gene/224914:BME_RS07910 ^@ http://purl.uniprot.org/uniprot/Q8YFD6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proline racemase family.|||Homotetramer.|||In vitro, catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp) and that of trans-3-hydroxy-L-proline (t3LHyp) to cis-3-hydroxy-D-proline (c3DHyp), albeit with very low efficiency. The physiological substrate may be different (PubMed:24980702). Displays neither proline racemase activity nor t3LHyp dehydratase activity (PubMed:17849014, PubMed:24980702). http://togogenome.org/gene/224914:BME_RS05140 ^@ http://purl.uniprot.org/uniprot/Q8YGX8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/224914:BME_RS04295 ^@ http://purl.uniprot.org/uniprot/Q8YHE1 ^@ Similarity ^@ Belongs to the ribosome association toxin RatA family. http://togogenome.org/gene/224914:BME_RS09150 ^@ http://purl.uniprot.org/uniprot/Q8YEN0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer. http://togogenome.org/gene/224914:BME_RS14505 ^@ http://purl.uniprot.org/uniprot/Q8YBL8 ^@ Similarity ^@ Belongs to the XFP family. http://togogenome.org/gene/224914:BME_RS13460 ^@ http://purl.uniprot.org/uniprot/Q8YC65 ^@ Similarity ^@ Belongs to the DprA/Smf family. http://togogenome.org/gene/224914:BME_RS08705 ^@ http://purl.uniprot.org/uniprot/Q8YEX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol monophosphatase superfamily. CysQ family.|||Cell inner membrane|||Converts adenosine-3',5'-bisphosphate (PAP) to AMP. http://togogenome.org/gene/224914:BME_RS09875 ^@ http://purl.uniprot.org/uniprot/Q8YE82 ^@ Cofactor|||Similarity ^@ Belongs to the prokaryotic GSH synthase family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/224914:BME_RS06700 ^@ http://purl.uniprot.org/uniprot/Q8YG31 ^@ Function|||Similarity ^@ Belongs to the CcmH/CycL/Ccl2/NrfF family.|||Possible subunit of a heme lyase. http://togogenome.org/gene/224914:BME_RS01225 ^@ http://purl.uniprot.org/uniprot/Q8YJ36 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase gamma chain family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. http://togogenome.org/gene/224914:BME_RS05790 ^@ http://purl.uniprot.org/uniprot/Q8YGK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 49 kDa subunit family.|||Cell inner membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/224914:BME_RS03810 ^@ http://purl.uniprot.org/uniprot/Q8YHN4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/224914:BME_RS01705 ^@ http://purl.uniprot.org/uniprot/P65878 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/224914:BME_RS00110 ^@ http://purl.uniprot.org/uniprot/Q8YJQ8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/224914:BME_RS13510 ^@ http://purl.uniprot.org/uniprot/Q8YC56 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type II topoisomerase GyrB family.|||Belongs to the type II topoisomerase family. ParE type 1 subfamily.|||Heterotetramer composed of ParC and ParE.|||Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. http://togogenome.org/gene/224914:BME_RS00160 ^@ http://purl.uniprot.org/uniprot/Q8YJP6 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily. http://togogenome.org/gene/224914:BME_RS10180 ^@ http://purl.uniprot.org/uniprot/P63824 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CoaE family.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS03855 ^@ http://purl.uniprot.org/uniprot/Q8YHM5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/224914:BME_RS03500 ^@ http://purl.uniprot.org/uniprot/Q8YHU0 ^@ Function ^@ Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin. http://togogenome.org/gene/224914:BME_RS00250 ^@ http://purl.uniprot.org/uniprot/P66140 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/224914:BME_RS08865 ^@ http://purl.uniprot.org/uniprot/Q8YEU0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.|||Cytoplasm|||Interacts with 100S ribosomes.|||Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. http://togogenome.org/gene/224914:BME_RS10840 ^@ http://purl.uniprot.org/uniprot/Q8YDP0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/224914:BME_RS03740 ^@ http://purl.uniprot.org/uniprot/Q8YHP8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/224914:BME_RS14270 ^@ http://purl.uniprot.org/uniprot/F8WJX4 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/224914:BME_RS01385 ^@ http://purl.uniprot.org/uniprot/Q8YJ02 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial solute-binding protein 1 family.|||Part of the ABC transporter complex ThiBPQ involved in thiamine import.|||Periplasm|||The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB). http://togogenome.org/gene/224914:BME_RS13275 ^@ http://purl.uniprot.org/uniprot/Q8YC99 ^@ Function|||Similarity ^@ Belongs to the leucine-binding protein family.|||Component of an amino-acid transport system. http://togogenome.org/gene/224914:BME_RS14415 ^@ http://purl.uniprot.org/uniprot/Q8YBN5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system (By similarity).|||The complex is composed of two ATP-binding proteins (BMEII0863 and BMEII0864), two transmembrane proteins (BMEII0860 and BMEII0861) and a solute-binding protein (BMEII0859). http://togogenome.org/gene/224914:BME_RS14595 ^@ http://purl.uniprot.org/uniprot/Q8YBK1 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/224914:BME_RS12130 ^@ http://purl.uniprot.org/uniprot/P0A2X9 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/224914:BME_RS01840 ^@ http://purl.uniprot.org/uniprot/Q8YIR8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.|||Belongs to the Fur family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/224914:BME_RS07155 ^@ http://purl.uniprot.org/uniprot/Q8YFU0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ureidoglycolate lyase family.|||Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source.|||Homodimer. http://togogenome.org/gene/224914:BME_RS04465 ^@ http://purl.uniprot.org/uniprot/Q8YHA5 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/224914:BME_RS01060 ^@ http://purl.uniprot.org/uniprot/Q8YJ71 ^@ Function|||Similarity ^@ Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.|||Belongs to the Nudix hydrolase family. RppH subfamily. http://togogenome.org/gene/224914:BME_RS12005 ^@ http://purl.uniprot.org/uniprot/Q8YD06 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/224914:BME_RS13050 ^@ http://purl.uniprot.org/uniprot/Q8YCE8 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/224914:BME_RS04125 ^@ http://purl.uniprot.org/uniprot/P94340 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/224914:BME_RS00595 ^@ http://purl.uniprot.org/uniprot/Q8YJF7 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/224914:BME_RS09490 ^@ http://purl.uniprot.org/uniprot/Q8YEG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS06400 ^@ http://purl.uniprot.org/uniprot/Q8YG89 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. http://togogenome.org/gene/224914:BME_RS04220 ^@ http://purl.uniprot.org/uniprot/Q8YHF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PpiC/parvulin rotamase family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/224914:BME_RS00860 ^@ http://purl.uniprot.org/uniprot/Q8YJA5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS03960 ^@ http://purl.uniprot.org/uniprot/Q8YHK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.|||Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/224914:BME_RS13115 ^@ http://purl.uniprot.org/uniprot/Q8YCD5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.|||Cytoplasm|||Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. http://togogenome.org/gene/224914:BME_RS00585 ^@ http://purl.uniprot.org/uniprot/Q8YJF9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Some bacteria possess a monofunctional ArgJ, i.e. capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/224914:BME_RS12305 ^@ http://purl.uniprot.org/uniprot/Q8YCU6 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/224914:BME_RS12160 ^@ http://purl.uniprot.org/uniprot/Q8YCX7 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/224914:BME_RS07335 ^@ http://purl.uniprot.org/uniprot/Q8YFQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Cell membrane|||Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.|||Membrane http://togogenome.org/gene/224914:BME_RS12385 ^@ http://purl.uniprot.org/uniprot/Q8YCS8 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/224914:BME_RS00065 ^@ http://purl.uniprot.org/uniprot/Q8YJR9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS05175 ^@ http://purl.uniprot.org/uniprot/Q8YGX0 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/224914:BME_RS11385 ^@ http://purl.uniprot.org/uniprot/Q8YDD2 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/224914:BME_RS13420 ^@ http://purl.uniprot.org/uniprot/Q8YC72 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/224914:BME_RS03040 ^@ http://purl.uniprot.org/uniprot/Q8YI35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. HflK subfamily.|||HflC and HflK could encode or regulate a protease.|||HflC and HflK may interact to form a multimeric complex.|||Membrane http://togogenome.org/gene/224914:BME_RS11485 ^@ http://purl.uniprot.org/uniprot/P64132 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/224914:BME_RS10370 ^@ http://purl.uniprot.org/uniprot/Q8YDY8 ^@ Subcellular Location Annotation ^@ Cell outer membrane http://togogenome.org/gene/224914:BME_RS15615 ^@ http://purl.uniprot.org/uniprot/Q8YAY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type III secretion exporter family.|||Cell membrane|||Membrane|||Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin. http://togogenome.org/gene/224914:BME_RS00510 ^@ http://purl.uniprot.org/uniprot/Q8YJH3 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/224914:BME_RS12925 ^@ http://purl.uniprot.org/uniprot/Q8YCH0 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/224914:BME_RS06250 ^@ http://purl.uniprot.org/uniprot/Q8YGB8 ^@ Function|||Similarity ^@ Belongs to the GART family.|||Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. http://togogenome.org/gene/224914:BME_RS04225 ^@ http://purl.uniprot.org/uniprot/Q8YHF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/224914:BME_RS10400 ^@ http://purl.uniprot.org/uniprot/Q8YDY2 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/224914:BME_RS14735 ^@ http://purl.uniprot.org/uniprot/Q8YBH0 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/224914:BME_RS02205 ^@ http://purl.uniprot.org/uniprot/Q8YIK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Cell membrane http://togogenome.org/gene/224914:BME_RS15660 ^@ http://purl.uniprot.org/uniprot/Q8YAX8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.|||Cell inner membrane|||Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD). http://togogenome.org/gene/224914:BME_RS08730 ^@ http://purl.uniprot.org/uniprot/Q8YEW8 ^@ Domain|||Function|||Similarity ^@ Belongs to the vitamin-B12 dependent methionine synthase family.|||Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.|||Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin. http://togogenome.org/gene/224914:BME_RS15280 ^@ http://purl.uniprot.org/uniprot/P0A342 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||By heat shock.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/224914:BME_RS08915 ^@ http://purl.uniprot.org/uniprot/Q8YES8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell inner membrane|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/224914:BME_RS14435 ^@ http://purl.uniprot.org/uniprot/Q8YBN1 ^@ Function|||Similarity ^@ Belongs to the leucine-binding protein family.|||Component of an amino-acid transport system. http://togogenome.org/gene/224914:BME_RS14115 ^@ http://purl.uniprot.org/uniprot/Q8YBT5 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/224914:BME_RS03215 ^@ http://purl.uniprot.org/uniprot/Q8YHZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UreE family.|||Cytoplasm|||Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. http://togogenome.org/gene/224914:BME_RS11840 ^@ http://purl.uniprot.org/uniprot/Q8YD38 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/224914:BME_RS10615 ^@ http://purl.uniprot.org/uniprot/Q8YDT8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS06535 ^@ http://purl.uniprot.org/uniprot/P66858 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/224914:BME_RS09555 ^@ http://purl.uniprot.org/uniprot/Q8YEE8 ^@ Function|||Similarity ^@ Belongs to the leucine-binding protein family.|||Component of an amino-acid transport system. http://togogenome.org/gene/224914:BME_RS03865 ^@ http://purl.uniprot.org/uniprot/P66570 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/224914:BME_RS01185 ^@ http://purl.uniprot.org/uniprot/Q8YJ45 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. http://togogenome.org/gene/224914:BME_RS00770 ^@ http://purl.uniprot.org/uniprot/Q8YJC4 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein. http://togogenome.org/gene/224914:BME_RS04400 ^@ http://purl.uniprot.org/uniprot/Q8YHB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/224914:BME_RS09010 ^@ http://purl.uniprot.org/uniprot/Q8YEQ9 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. http://togogenome.org/gene/224914:BME_RS10585 ^@ http://purl.uniprot.org/uniprot/Q8YDU4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the P-Pant transferase superfamily. EntD family.|||EntB, EntD, EntE, and EntF form a multienzyme complex called enterobactin synthase.|||Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. Plays an essential role in the assembly of the enterobactin by catalyzing the transfer of the 4'-phosphopantetheine (Ppant) moiety from coenzyme A to the apo-domains of both EntB (ArCP domain) and EntF (PCP domain) to yield their holo-forms which make them competent for the activation of 2,3-dihydroxybenzoate (DHB) and L-serine, respectively. http://togogenome.org/gene/224914:BME_RS02950 ^@ http://purl.uniprot.org/uniprot/Q8YI52 ^@ Similarity ^@ Belongs to the SCO1/2 family. http://togogenome.org/gene/224914:BME_RS05560 ^@ http://purl.uniprot.org/uniprot/Q8YGP9 ^@ Similarity ^@ Belongs to the aldose epimerase family. http://togogenome.org/gene/224914:BME_RS14955 ^@ http://purl.uniprot.org/uniprot/Q8YBC0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/224914:BME_RS05470 ^@ http://purl.uniprot.org/uniprot/P63933 ^@ Similarity ^@ Belongs to the dGTPase family. Type 2 subfamily. http://togogenome.org/gene/224914:BME_RS04860 ^@ http://purl.uniprot.org/uniprot/Q8YH29 ^@ Function|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.|||Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. http://togogenome.org/gene/224914:BME_RS07610 ^@ http://purl.uniprot.org/uniprot/Q8YFJ4 ^@ Similarity ^@ Belongs to the RelE toxin family. http://togogenome.org/gene/224914:BME_RS13950 ^@ http://purl.uniprot.org/uniprot/Q8YBW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS04000 ^@ http://purl.uniprot.org/uniprot/Q8YHJ6 ^@ Similarity ^@ Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family. http://togogenome.org/gene/224914:BME_RS04240 ^@ http://purl.uniprot.org/uniprot/Q8YHF2 ^@ Activity Regulation|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer. http://togogenome.org/gene/224914:BME_RS10275 ^@ http://purl.uniprot.org/uniprot/P0A3N8 ^@ Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the rhizobiaceae omp10 lipoprotein family.|||Cell outer membrane|||Elicits an immune response in B.melitensis-infected sheep but not in B.abortus-infected cattle. http://togogenome.org/gene/224914:BME_RS03030 ^@ http://purl.uniprot.org/uniprot/P67042 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/224914:BME_RS03900 ^@ http://purl.uniprot.org/uniprot/Q8YHL6 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/224914:BME_RS01350 ^@ http://purl.uniprot.org/uniprot/Q8YJ09 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/224914:BME_RS12480 ^@ http://purl.uniprot.org/uniprot/Q8YCR0 ^@ Similarity ^@ Belongs to the UPF0166 family. http://togogenome.org/gene/224914:BME_RS09165 ^@ http://purl.uniprot.org/uniprot/Q8YEM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmC/CycZ/HelC family.|||Cell inner membrane|||Membrane|||Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. http://togogenome.org/gene/224914:BME_RS13095 ^@ http://purl.uniprot.org/uniprot/Q8YCE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Cell membrane http://togogenome.org/gene/224914:BME_RS06330 ^@ http://purl.uniprot.org/uniprot/Q8YGA3 ^@ Similarity ^@ Belongs to the DinB family. http://togogenome.org/gene/224914:BME_RS05515 ^@ http://purl.uniprot.org/uniprot/Q8YGQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell inner membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. http://togogenome.org/gene/224914:BME_RS13225 ^@ http://purl.uniprot.org/uniprot/Q8YCB1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. sn-glycerol-3-phosphate importer (TC 3.A.1.1.3) family.|||Cell inner membrane|||Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB). http://togogenome.org/gene/224914:BME_RS00450 ^@ http://purl.uniprot.org/uniprot/Q8YJI7 ^@ Similarity ^@ Belongs to the ETF beta-subunit/FixA family. http://togogenome.org/gene/224914:BME_RS14740 ^@ http://purl.uniprot.org/uniprot/P65546 ^@ Function|||Similarity ^@ Belongs to the NrdI family.|||Probably involved in ribonucleotide reductase function. http://togogenome.org/gene/224914:BME_RS05745 ^@ http://purl.uniprot.org/uniprot/Q8YGL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Membrane http://togogenome.org/gene/224914:BME_RS10695 ^@ http://purl.uniprot.org/uniprot/Q8YDS0 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane|||Heme transporter.|||Induced in absence of iron. http://togogenome.org/gene/224914:BME_RS04290 ^@ http://purl.uniprot.org/uniprot/P65281 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS09090 ^@ http://purl.uniprot.org/uniprot/Q8YEP2 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/224914:BME_RS10500 ^@ http://purl.uniprot.org/uniprot/Q8YDV9 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/224914:BME_RS06645 ^@ http://purl.uniprot.org/uniprot/Q8YG42 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/224914:BME_RS09935 ^@ http://purl.uniprot.org/uniprot/P66101 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/224914:BME_RS15180 ^@ http://purl.uniprot.org/uniprot/P65489 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/224914:BME_RS01775 ^@ http://purl.uniprot.org/uniprot/F8WJP5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ExbD/TolR family.|||Cell membrane|||Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.|||Membrane|||The accessory proteins ExbB and ExbD seem to form a complex with TonB. http://togogenome.org/gene/224914:BME_RS04930 ^@ http://purl.uniprot.org/uniprot/Q8YH15 ^@ Function|||Similarity ^@ Belongs to the thymidylate kinase family.|||Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. http://togogenome.org/gene/224914:BME_RS10625 ^@ http://purl.uniprot.org/uniprot/Q8YDT6 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/224914:BME_RS15190 ^@ http://purl.uniprot.org/uniprot/P65325 ^@ Function|||Similarity ^@ Belongs to the LpxK family.|||Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). http://togogenome.org/gene/224914:BME_RS03780 ^@ http://purl.uniprot.org/uniprot/Q8YHP0 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||Methylated by PrmB.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/224914:BME_RS07405 ^@ http://purl.uniprot.org/uniprot/Q8YFN7 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/224914:BME_RS00740 ^@ http://purl.uniprot.org/uniprot/P66078 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/224914:BME_RS11490 ^@ http://purl.uniprot.org/uniprot/Q8YDB2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer. http://togogenome.org/gene/224914:BME_RS15295 ^@ http://purl.uniprot.org/uniprot/Q8YB50 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Cytoplasm|||Homotetramer.|||Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.|||There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors. http://togogenome.org/gene/224914:BME_RS10020 ^@ http://purl.uniprot.org/uniprot/Q8YE56 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/224914:BME_RS06705 ^@ http://purl.uniprot.org/uniprot/Q8YG30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/224914:BME_RS07375 ^@ http://purl.uniprot.org/uniprot/P63437 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS08180 ^@ http://purl.uniprot.org/uniprot/Q8YF79 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20 family.|||Binds 2 Zn(2+) ions per subunit. http://togogenome.org/gene/224914:BME_RS00060 ^@ http://purl.uniprot.org/uniprot/Q8YJS0 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/224914:BME_RS07295 ^@ http://purl.uniprot.org/uniprot/Q8YFR2 ^@ Similarity ^@ Belongs to the pseudomonas-type ThrB family. http://togogenome.org/gene/224914:BME_RS11335 ^@ http://purl.uniprot.org/uniprot/Q8YDE5 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/224914:BME_RS05750 ^@ http://purl.uniprot.org/uniprot/Q8YGL1 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/224914:BME_RS05085 ^@ http://purl.uniprot.org/uniprot/Q8YGY9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I fumarase family.|||Catalyzes the reversible hydration of fumarate to (S)-malate.|||Homodimer. http://togogenome.org/gene/224914:BME_RS14570 ^@ http://purl.uniprot.org/uniprot/Q8YBK6 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/224914:BME_RS14860 ^@ http://purl.uniprot.org/uniprot/Q8YBD9 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/224914:BME_RS06045 ^@ http://purl.uniprot.org/uniprot/P67012 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/224914:BME_RS14945 ^@ http://purl.uniprot.org/uniprot/Q8YBC2 ^@ Similarity ^@ Belongs to the MbcT/ParT/Res family. http://togogenome.org/gene/224914:BME_RS06300 ^@ http://purl.uniprot.org/uniprot/Q8YGA9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/224914:BME_RS03545 ^@ http://purl.uniprot.org/uniprot/Q8YHT2 ^@ Similarity ^@ Belongs to the CobH/CbiC family. http://togogenome.org/gene/224914:BME_RS10315 ^@ http://purl.uniprot.org/uniprot/Q8YDZ5 ^@ Similarity ^@ Belongs to the virb1 family. http://togogenome.org/gene/224914:BME_RS03195 ^@ http://purl.uniprot.org/uniprot/Q8YI03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urea transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/224914:BME_RS03565 ^@ http://purl.uniprot.org/uniprot/P65955 ^@ Similarity ^@ Belongs to the UPF0758 family. http://togogenome.org/gene/224914:BME_RS12175 ^@ http://purl.uniprot.org/uniprot/Q8YCX4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/224914:BME_RS00755 ^@ http://purl.uniprot.org/uniprot/Q8YJC7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b560 family.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH).|||Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.|||The heme is bound between the two transmembrane subunits. http://togogenome.org/gene/224914:BME_RS07575 ^@ http://purl.uniprot.org/uniprot/Q8YFK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.|||Cell inner membrane http://togogenome.org/gene/224914:BME_RS01890 ^@ http://purl.uniprot.org/uniprot/Q8YIQ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS02870 ^@ http://purl.uniprot.org/uniprot/Q8YI68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).|||Cytoplasm http://togogenome.org/gene/224914:BME_RS05430 ^@ http://purl.uniprot.org/uniprot/Q8YGS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell inner membrane|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.|||The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. http://togogenome.org/gene/224914:BME_RS07110 ^@ http://purl.uniprot.org/uniprot/F8WJP6 ^@ Disruption Phenotype|||Function|||Similarity|||Subunit ^@ Belongs to the Fmt family.|||Deletion mutant is completely O-antigen-negative.|||Homodimer.|||Involved in the lipopolysaccharide (LPS) O-antigen biosynthesis (PubMed:11081580). Catalyzes the transfer of a formyl group to GDP-perosamine, leading to the formation of GDP-N-formylperosamine (PubMed:11081580, PubMed:28636341). In vitro, can also function on GDP-3-deoxyperosamine, thereby providing an enzymatic method for producing a novel trideoxysugar not found in nature (PubMed:28636341). http://togogenome.org/gene/224914:BME_RS00040 ^@ http://purl.uniprot.org/uniprot/Q8YJS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. http://togogenome.org/gene/224914:BME_RS08925 ^@ http://purl.uniprot.org/uniprot/Q8YES6 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. http://togogenome.org/gene/224914:BME_RS03220 ^@ http://purl.uniprot.org/uniprot/Q8YHZ8 ^@ Cofactor|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.|||Binds 2 nickel ions per subunit.|||Carboxylation allows a single lysine to coordinate two nickel ions.|||Cytoplasm|||Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. http://togogenome.org/gene/224914:BME_RS13555 ^@ http://purl.uniprot.org/uniprot/Q8YC48 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.|||Cytoplasm|||Homotrimer.|||In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/224914:BME_RS12560 ^@ http://purl.uniprot.org/uniprot/Q8YCP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 5 family.|||Periplasm http://togogenome.org/gene/224914:BME_RS10925 ^@ http://purl.uniprot.org/uniprot/Q8YDM1 ^@ Similarity ^@ Belongs to the MotB family. http://togogenome.org/gene/224914:BME_RS07950 ^@ http://purl.uniprot.org/uniprot/Q8YFC6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS03730 ^@ http://purl.uniprot.org/uniprot/Q8YHP9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex (By similarity). http://togogenome.org/gene/224914:BME_RS15650 ^@ http://purl.uniprot.org/uniprot/Q8YAY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Cell membrane http://togogenome.org/gene/224914:BME_RS11135 ^@ http://purl.uniprot.org/uniprot/Q8YDI4 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/224914:BME_RS10815 ^@ http://purl.uniprot.org/uniprot/Q8YDP5 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/224914:BME_RS04825 ^@ http://purl.uniprot.org/uniprot/Q8YH36 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Monomer. http://togogenome.org/gene/224914:BME_RS04455 ^@ http://purl.uniprot.org/uniprot/Q8YHA8 ^@ Similarity ^@ To bacterial alkanal monooxygenase alpha and beta chains. http://togogenome.org/gene/224914:BME_RS13990 ^@ http://purl.uniprot.org/uniprot/Q8YBV9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dethiobiotin synthetase family.|||Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/224914:BME_RS05990 ^@ http://purl.uniprot.org/uniprot/P67311 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/224914:BME_RS09435 ^@ http://purl.uniprot.org/uniprot/Q8YEH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.|||Belongs to the KdsB family.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS09175 ^@ http://purl.uniprot.org/uniprot/Q8YEM5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.|||Cell inner membrane|||Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB). http://togogenome.org/gene/224914:BME_RS09710 ^@ http://purl.uniprot.org/uniprot/Q8YEB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm|||Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. http://togogenome.org/gene/224914:BME_RS01105 ^@ http://purl.uniprot.org/uniprot/Q8YJ61 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Cell inner membrane|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule. http://togogenome.org/gene/224914:BME_RS05870 ^@ http://purl.uniprot.org/uniprot/Q8YGJ1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/224914:BME_RS05510 ^@ http://purl.uniprot.org/uniprot/Q8YGQ9 ^@ Function|||Similarity ^@ Belongs to the CobT family.|||Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). http://togogenome.org/gene/224914:BME_RS00915 ^@ http://purl.uniprot.org/uniprot/Q8YJ94 ^@ Function|||Similarity ^@ Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.|||Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. http://togogenome.org/gene/224914:BME_RS07020 ^@ http://purl.uniprot.org/uniprot/Q8YFW7 ^@ Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 2 family. http://togogenome.org/gene/224914:BME_RS09180 ^@ http://purl.uniprot.org/uniprot/Q8YEM3 ^@ Function|||Similarity ^@ Belongs to the aconitase/IPM isomerase family.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. http://togogenome.org/gene/224914:BME_RS07300 ^@ http://purl.uniprot.org/uniprot/Q8YFR1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspH family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. http://togogenome.org/gene/224914:BME_RS00005 ^@ http://purl.uniprot.org/uniprot/Q8YJT1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/224914:BME_RS12050 ^@ http://purl.uniprot.org/uniprot/Q8YCZ7 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/224914:BME_RS11260 ^@ http://purl.uniprot.org/uniprot/Q7CNS6 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/224914:BME_RS10010 ^@ http://purl.uniprot.org/uniprot/Q8YE58 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccD/PCCB family.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS03830 ^@ http://purl.uniprot.org/uniprot/Q8YHN0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/224914:BME_RS00905 ^@ http://purl.uniprot.org/uniprot/Q8YJ96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PEP-utilizing enzyme family.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS07415 ^@ http://purl.uniprot.org/uniprot/Q8YFN5 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. http://togogenome.org/gene/224914:BME_RS15640 ^@ http://purl.uniprot.org/uniprot/Q8YAY2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS11280 ^@ http://purl.uniprot.org/uniprot/Q7CNS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system. http://togogenome.org/gene/224914:BME_RS02400 ^@ http://purl.uniprot.org/uniprot/P65863 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/224914:BME_RS10680 ^@ http://purl.uniprot.org/uniprot/Q8YDS3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS01500 ^@ http://purl.uniprot.org/uniprot/Q8YIY0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/224914:BME_RS06620 ^@ http://purl.uniprot.org/uniprot/Q8YG46 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/224914:BME_RS13820 ^@ http://purl.uniprot.org/uniprot/Q8YBZ5 ^@ Similarity ^@ Belongs to the peptidase S58 family. http://togogenome.org/gene/224914:BME_RS07305 ^@ http://purl.uniprot.org/uniprot/Q8YFR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF1 family.|||Cell membrane http://togogenome.org/gene/224914:BME_RS06315 ^@ http://purl.uniprot.org/uniprot/P65396 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaE family.|||Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity).|||Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis (By similarity). http://togogenome.org/gene/224914:BME_RS09160 ^@ http://purl.uniprot.org/uniprot/Q8YEM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmD/CycX/HelD family.|||Cell inner membrane|||Membrane|||Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. http://togogenome.org/gene/224914:BME_RS14690 ^@ http://purl.uniprot.org/uniprot/Q8YBH8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.|||Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD). http://togogenome.org/gene/224914:BME_RS03975 ^@ http://purl.uniprot.org/uniprot/Q8YHK1 ^@ Function|||Subcellular Location Annotation ^@ Cell inner membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system. http://togogenome.org/gene/224914:BME_RS07865 ^@ http://purl.uniprot.org/uniprot/Q8YFE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polysaccharide deacetylase family.|||Cytoplasm|||Is involved in generating a small heat-stable compound (Nod), an acylated oligomer of N-acetylglucosamine, that stimulates mitosis in various plant protoplasts. http://togogenome.org/gene/224914:BME_RS00630 ^@ http://purl.uniprot.org/uniprot/Q8YJF0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the diaminopimelate epimerase family.|||Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/224914:BME_RS03945 ^@ http://purl.uniprot.org/uniprot/Q8YHK6 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/224914:BME_RS06500 ^@ http://purl.uniprot.org/uniprot/Q8YG68 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Monomer. http://togogenome.org/gene/224914:BME_RS11525 ^@ http://purl.uniprot.org/uniprot/Q8YDA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS03575 ^@ http://purl.uniprot.org/uniprot/Q8YHS6 ^@ Similarity ^@ Belongs to the SfsA family. http://togogenome.org/gene/224914:BME_RS04755 ^@ http://purl.uniprot.org/uniprot/Q8YH48 ^@ Function|||Similarity ^@ Belongs to the DHPS family.|||Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives. http://togogenome.org/gene/224914:BME_RS04380 ^@ http://purl.uniprot.org/uniprot/Q8YHC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/224914:BME_RS04135 ^@ http://purl.uniprot.org/uniprot/Q8YHH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Cell inner membrane http://togogenome.org/gene/224914:BME_RS12745 ^@ http://purl.uniprot.org/uniprot/Q8YCK5 ^@ Function|||Similarity ^@ Belongs to the glutamine synthetase family.|||Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. http://togogenome.org/gene/224914:BME_RS07900 ^@ http://purl.uniprot.org/uniprot/Q8YFD8 ^@ Similarity ^@ Belongs to the IalB family. http://togogenome.org/gene/224914:BME_RS09200 ^@ http://purl.uniprot.org/uniprot/Q8YEL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/224914:BME_RS07255 ^@ http://purl.uniprot.org/uniprot/Q8YFS0 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/224914:BME_RS05665 ^@ http://purl.uniprot.org/uniprot/Q8YGM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Bcr/CmlA family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/224914:BME_RS00380 ^@ http://purl.uniprot.org/uniprot/Q8YJK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS01685 ^@ http://purl.uniprot.org/uniprot/Q8YIU6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS04640 ^@ http://purl.uniprot.org/uniprot/Q8YH72 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/224914:BME_RS05425 ^@ http://purl.uniprot.org/uniprot/Q8YGS6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/224914:BME_RS07755 ^@ http://purl.uniprot.org/uniprot/Q8YFG5 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/224914:BME_RS04350 ^@ http://purl.uniprot.org/uniprot/P0A3G7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Hfq family.|||Homohexamer.|||RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. http://togogenome.org/gene/224914:BME_RS02930 ^@ http://purl.uniprot.org/uniprot/Q8YI56 ^@ Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. http://togogenome.org/gene/224914:BME_RS08595 ^@ http://purl.uniprot.org/uniprot/Q8YEZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/224914:BME_RS00555 ^@ http://purl.uniprot.org/uniprot/Q8YJG5 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/224914:BME_RS05415 ^@ http://purl.uniprot.org/uniprot/Q8YGS8 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/224914:BME_RS07990 ^@ http://purl.uniprot.org/uniprot/Q8YFB7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MscL family.|||Cell inner membrane|||Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.|||Homopentamer. http://togogenome.org/gene/224914:BME_RS10290 ^@ http://purl.uniprot.org/uniprot/Q8YE00 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS03160 ^@ http://purl.uniprot.org/uniprot/Q8YI11 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.|||Cell inner membrane|||Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function. http://togogenome.org/gene/224914:BME_RS08940 ^@ http://purl.uniprot.org/uniprot/Q8YES3 ^@ Activity Regulation|||Domain|||Function|||Similarity ^@ Belongs to the GlnD family.|||Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.|||Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.|||Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity. http://togogenome.org/gene/224914:BME_RS01855 ^@ http://purl.uniprot.org/uniprot/Q8YIR6 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/224914:BME_RS01285 ^@ http://purl.uniprot.org/uniprot/Q8YJ23 ^@ Function|||Similarity ^@ Belongs to the leucine-binding protein family.|||Component of an amino-acid transport system. http://togogenome.org/gene/224914:BME_RS00660 ^@ http://purl.uniprot.org/uniprot/Q8YJE4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the alpha-ketoglutarate dehydrogenase family.|||E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).|||Homodimer. Part of the 2-oxoglutarate dehydrogenase (OGDH) complex composed of E1 (2-oxoglutarate dehydrogenase), E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase); the complex contains multiple copies of the three enzymatic components (E1, E2 and E3). http://togogenome.org/gene/224914:BME_RS01960 ^@ http://purl.uniprot.org/uniprot/Q8YIQ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS11590 ^@ http://purl.uniprot.org/uniprot/Q8YD92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Cell membrane|||Membrane|||Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/224914:BME_RS09730 ^@ http://purl.uniprot.org/uniprot/Q8YEB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/224914:BME_RS06325 ^@ http://purl.uniprot.org/uniprot/Q8YGA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NDK family.|||Cytoplasm|||Homotetramer.|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/224914:BME_RS02250 ^@ http://purl.uniprot.org/uniprot/Q8YIJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.|||Membrane http://togogenome.org/gene/224914:BME_RS14475 ^@ http://purl.uniprot.org/uniprot/Q8YBM4 ^@ Function|||Similarity ^@ Belongs to the leucine-binding protein family.|||Component of an amino-acid transport system. http://togogenome.org/gene/224914:BME_RS09035 ^@ http://purl.uniprot.org/uniprot/Q8YEQ4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/224914:BME_RS09100 ^@ http://purl.uniprot.org/uniprot/P63353 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.|||Cell inner membrane|||Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP). http://togogenome.org/gene/224914:BME_RS10170 ^@ http://purl.uniprot.org/uniprot/Q8YE23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecB family.|||Cytoplasm|||Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.|||One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. http://togogenome.org/gene/224914:BME_RS05935 ^@ http://purl.uniprot.org/uniprot/P64390 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial histone-like protein family.|||Heterodimer of an alpha and a beta chain.|||This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. http://togogenome.org/gene/224914:BME_RS05625 ^@ http://purl.uniprot.org/uniprot/Q8YGN6 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/224914:BME_RS06460 ^@ http://purl.uniprot.org/uniprot/Q8YG76 ^@ Function|||Similarity ^@ Belongs to the RecO family.|||Involved in DNA repair and RecF pathway recombination. http://togogenome.org/gene/224914:BME_RS06305 ^@ http://purl.uniprot.org/uniprot/Q8YGA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/224914:BME_RS06530 ^@ http://purl.uniprot.org/uniprot/Q8YG62 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family. http://togogenome.org/gene/224914:BME_RS06980 ^@ http://purl.uniprot.org/uniprot/Q8YFX5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xylose isomerase family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/224914:BME_RS12485 ^@ http://purl.uniprot.org/uniprot/Q8YCQ9 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.|||Cell inner membrane|||Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function. http://togogenome.org/gene/224914:BME_RS05880 ^@ http://purl.uniprot.org/uniprot/Q8YGI9 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/224914:BME_RS12650 ^@ http://purl.uniprot.org/uniprot/Q8YCM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 5 family.|||Periplasm http://togogenome.org/gene/224914:BME_RS09495 ^@ http://purl.uniprot.org/uniprot/Q8YEG1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Monomer. http://togogenome.org/gene/224914:BME_RS02925 ^@ http://purl.uniprot.org/uniprot/Q8YI57 ^@ Function|||Similarity ^@ Belongs to the RecN family.|||May be involved in recombinational repair of damaged DNA. http://togogenome.org/gene/224914:BME_RS09605 ^@ http://purl.uniprot.org/uniprot/Q8YED7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/224914:BME_RS12630 ^@ http://purl.uniprot.org/uniprot/Q8YCM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS11325 ^@ http://purl.uniprot.org/uniprot/Q8YDE7 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/224914:BME_RS06465 ^@ http://purl.uniprot.org/uniprot/Q8YG75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell inner membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/224914:BME_RS08195 ^@ http://purl.uniprot.org/uniprot/Q8YF76 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/224914:BME_RS00650 ^@ http://purl.uniprot.org/uniprot/P66867 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/224914:BME_RS10955 ^@ http://purl.uniprot.org/uniprot/Q8YDL5 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum|||Belongs to the flagella basal body rod proteins family.|||Secreted http://togogenome.org/gene/224914:BME_RS13150 ^@ http://purl.uniprot.org/uniprot/Q8YCC8 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/224914:BME_RS10325 ^@ http://purl.uniprot.org/uniprot/Q9RPY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the virB3 family.|||Cell membrane http://togogenome.org/gene/224914:BME_RS09770 ^@ http://purl.uniprot.org/uniprot/Q8YEA5 ^@ Similarity ^@ Belongs to the UPF0053 family. Hemolysin C subfamily. http://togogenome.org/gene/224914:BME_RS06870 ^@ http://purl.uniprot.org/uniprot/Q8YFZ7 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/224914:BME_RS04880 ^@ http://purl.uniprot.org/uniprot/Q8YH25 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutamine synthetase family.|||Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.|||Cytoplasm|||Oligomer of 12 subunits arranged in the form of two hexagons.|||Oligomer of 12 subunits arranged in the form of two hexameric ring. http://togogenome.org/gene/224914:BME_RS01115 ^@ http://purl.uniprot.org/uniprot/P66433 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/224914:BME_RS03415 ^@ http://purl.uniprot.org/uniprot/Q8YHV7 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/224914:BME_RS01830 ^@ http://purl.uniprot.org/uniprot/Q8YIS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0391 family.|||Cell membrane http://togogenome.org/gene/224914:BME_RS00835 ^@ http://purl.uniprot.org/uniprot/Q8YJB0 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Monomer.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/224914:BME_RS13790 ^@ http://purl.uniprot.org/uniprot/Q8YC00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 5 family.|||Periplasm http://togogenome.org/gene/224914:BME_RS01315 ^@ http://purl.uniprot.org/uniprot/Q8YJ16 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/224914:BME_RS12495 ^@ http://purl.uniprot.org/uniprot/Q8YCQ6 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/224914:BME_RS09460 ^@ http://purl.uniprot.org/uniprot/P67260 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YbaB/EbfC family.|||Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.|||Homodimer.|||nucleoid http://togogenome.org/gene/224914:BME_RS02940 ^@ http://purl.uniprot.org/uniprot/Q8YI54 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/224914:BME_RS03230 ^@ http://purl.uniprot.org/uniprot/Q8YHZ6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the urease gamma subunit family.|||Cytoplasm|||Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. http://togogenome.org/gene/224914:BME_RS00170 ^@ http://purl.uniprot.org/uniprot/Q8YJP4 ^@ Similarity ^@ Belongs to the YkuD family. http://togogenome.org/gene/224914:BME_RS01665 ^@ http://purl.uniprot.org/uniprot/Q8YIV0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA(Ile)-lysidine synthase family.|||Cytoplasm|||Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.|||The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding. http://togogenome.org/gene/224914:BME_RS07665 ^@ http://purl.uniprot.org/uniprot/Q8YFI3 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. IspE subfamily.|||Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. http://togogenome.org/gene/224914:BME_RS06565 ^@ http://purl.uniprot.org/uniprot/Q8YG56 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alphaproteobacteria porin family.|||Cell outer membrane|||Consists of 16-stranded beta-barrel sheets, with large surface-exposed loops, that form a transmembrane pore at the center of each barrel. The pore is partially ocluded by a peptide loop that folds into the pore lumen.|||Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.|||Homotrimer.|||The pore formed by Omp2a is larger than the one formed by Omp2b. Omp2b pores have optimal permeability to allow growth and protection against harmful compounds. The larger pore formed by Omp2a may be advantageous for intracellular growth, when the bacterium is competing with the host cell for nutrients whose concentration is particularly low within the phagosome. http://togogenome.org/gene/224914:BME_RS01215 ^@ http://purl.uniprot.org/uniprot/Q8YJ38 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase delta chain family.|||Cell inner membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. http://togogenome.org/gene/224914:BME_RS03745 ^@ http://purl.uniprot.org/uniprot/Q8YHP7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/224914:BME_RS04620 ^@ http://purl.uniprot.org/uniprot/Q8YH76 ^@ Similarity ^@ Belongs to the acetyl-CoA hydrolase/transferase family. http://togogenome.org/gene/224914:BME_RS08795 ^@ http://purl.uniprot.org/uniprot/P64305 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/224914:BME_RS04015 ^@ http://purl.uniprot.org/uniprot/Q8YHJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).|||Cytoplasm http://togogenome.org/gene/224914:BME_RS03365 ^@ http://purl.uniprot.org/uniprot/Q8YHW6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Belongs to the SecD/SecF family. SecF subfamily.|||Cell inner membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/224914:BME_RS04735 ^@ http://purl.uniprot.org/uniprot/Q8YH52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0283 family.|||Cell inner membrane http://togogenome.org/gene/224914:BME_RS02315 ^@ http://purl.uniprot.org/uniprot/Q8YII1 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/224914:BME_RS11420 ^@ http://purl.uniprot.org/uniprot/Q8YDC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial glucokinase family.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS10335 ^@ http://purl.uniprot.org/uniprot/Q8YDZ3 ^@ Similarity ^@ Belongs to the virb5 family. http://togogenome.org/gene/224914:BME_RS11770 ^@ http://purl.uniprot.org/uniprot/Q8YD54 ^@ Similarity ^@ Belongs to the AlaDH/PNT family. http://togogenome.org/gene/224914:BME_RS10110 ^@ http://purl.uniprot.org/uniprot/Q8YE36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS05475 ^@ http://purl.uniprot.org/uniprot/Q8YGR7 ^@ Similarity ^@ Belongs to the HesB/IscA family. http://togogenome.org/gene/224914:BME_RS13260 ^@ http://purl.uniprot.org/uniprot/Q8YCA3 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/224914:BME_RS09475 ^@ http://purl.uniprot.org/uniprot/Q8YEG5 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/224914:BME_RS03890 ^@ http://purl.uniprot.org/uniprot/P66381 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/224914:BME_RS02715 ^@ http://purl.uniprot.org/uniprot/Q8YIA2 ^@ Similarity ^@ Belongs to the peptidase C59 family. http://togogenome.org/gene/224914:BME_RS08245 ^@ http://purl.uniprot.org/uniprot/Q8YF70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UreD family.|||Cytoplasm|||Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.|||UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. http://togogenome.org/gene/224914:BME_RS04530 ^@ http://purl.uniprot.org/uniprot/Q8YH94 ^@ Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase I family.|||Toroid-shaped homodecamer, composed of two pentamers of five dimers. http://togogenome.org/gene/224914:BME_RS10510 ^@ http://purl.uniprot.org/uniprot/Q8YDV7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS04945 ^@ http://purl.uniprot.org/uniprot/Q8YH12 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/224914:BME_RS10950 ^@ http://purl.uniprot.org/uniprot/Q8YDL6 ^@ Caution|||Disruption Phenotype|||Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ A flgE mutant is attenuated in a murine model of infection. Four weeks after infection, the number of cfu per spleen from mice infected with the mutant is significantly lower than the number from mice infected with the wild-type.|||Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family.|||Despite the presence of a stop codon in position 243 in the fliF gene and in position 127 in the flhA gene, it has been shown that B.melitensis is able to express genes corresponding to the M ring, the hook and the filament of the flagellar apparatus in the early log phase of growth in 2YT broth. Under these conditions, a polar and sheathed flagellar structure is visible by transmission electron microscopy.|||Expressed at the onset of the exponential phase (after 4, 8 and 12 hours of culture) but not at later time points.|||The flagellum is required to cause a persistent disease in a murine model of infection. http://togogenome.org/gene/224914:BME_RS15590 ^@ http://purl.uniprot.org/uniprot/Q8YAZ1 ^@ Function ^@ FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. http://togogenome.org/gene/224914:BME_RS08150 ^@ http://purl.uniprot.org/uniprot/Q8YF86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI family.|||Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS10675 ^@ http://purl.uniprot.org/uniprot/Q8YDS4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS10700 ^@ http://purl.uniprot.org/uniprot/Q8YDR9 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/224914:BME_RS14695 ^@ http://purl.uniprot.org/uniprot/Q8YBH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 1 family.|||Periplasm http://togogenome.org/gene/224914:BME_RS05915 ^@ http://purl.uniprot.org/uniprot/Q8YGI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial sugar transferase family.|||Membrane http://togogenome.org/gene/224914:BME_RS12765 ^@ http://purl.uniprot.org/uniprot/Q8YCK1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseA family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/224914:BME_RS11185 ^@ http://purl.uniprot.org/uniprot/Q7CNS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Cell membrane|||Membrane|||Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/224914:BME_RS02905 ^@ http://purl.uniprot.org/uniprot/Q8YI61 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.|||Cell inner membrane|||Self-interacts. Interacts with FtsZ. http://togogenome.org/gene/224914:BME_RS13125 ^@ http://purl.uniprot.org/uniprot/Q8YCD3 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/224914:BME_RS07555 ^@ http://purl.uniprot.org/uniprot/Q8YFK8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. http://togogenome.org/gene/224914:BME_RS05375 ^@ http://purl.uniprot.org/uniprot/P64232 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmG family. TrmFO subfamily.|||Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS15480 ^@ http://purl.uniprot.org/uniprot/P67706 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliE family.|||Brucella species display species-specific inactivation of flagellar genes and are consequently nonmotile. http://togogenome.org/gene/224914:BME_RS13935 ^@ http://purl.uniprot.org/uniprot/Q8YBX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.|||Cell membrane|||Membrane http://togogenome.org/gene/224914:BME_RS01310 ^@ http://purl.uniprot.org/uniprot/Q8YJ17 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspG family.|||Binds 1 [4Fe-4S] cluster.|||Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. http://togogenome.org/gene/224914:BME_RS04885 ^@ http://purl.uniprot.org/uniprot/Q8YH24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP12 family.|||Mitochondrion http://togogenome.org/gene/224914:BME_RS15035 ^@ http://purl.uniprot.org/uniprot/Q8YBA3 ^@ Similarity ^@ Belongs to the CbbQ/NirQ/NorQ/GpvN family. http://togogenome.org/gene/224914:BME_RS00410 ^@ http://purl.uniprot.org/uniprot/Q8YJJ5 ^@ Similarity ^@ Belongs to the UPF0178 family. http://togogenome.org/gene/224914:BME_RS14375 ^@ http://purl.uniprot.org/uniprot/Q8YBP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NanM family.|||Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses.|||Homodimer.|||Periplasm http://togogenome.org/gene/224914:BME_RS03850 ^@ http://purl.uniprot.org/uniprot/Q8YHM6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/224914:BME_RS03610 ^@ http://purl.uniprot.org/uniprot/Q8YHS0 ^@ Similarity ^@ Belongs to the FBPase class 2 family. http://togogenome.org/gene/224914:BME_RS07620 ^@ http://purl.uniprot.org/uniprot/Q8YFJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUA5 family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/224914:BME_RS04580 ^@ http://purl.uniprot.org/uniprot/Q8YH83 ^@ Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Homodimer. http://togogenome.org/gene/224914:BME_RS03420 ^@ http://purl.uniprot.org/uniprot/Q8YHV6 ^@ Function|||Similarity ^@ Belongs to the CobB/CobQ family. CobQ subfamily.|||Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. http://togogenome.org/gene/224914:BME_RS07290 ^@ http://purl.uniprot.org/uniprot/P66673 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase H family.|||Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Monomer. http://togogenome.org/gene/224914:BME_RS05290 ^@ http://purl.uniprot.org/uniprot/Q8YGV0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase E/G family. RNase E subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per homotetramer.|||Cell inner membrane|||Cytoplasm|||Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.|||Homotetramer formed by a dimer of dimers. http://togogenome.org/gene/224914:BME_RS05715 ^@ http://purl.uniprot.org/uniprot/Q8YGL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/224914:BME_RS08305 ^@ http://purl.uniprot.org/uniprot/P67567 ^@ Similarity ^@ Belongs to the UPF0262 family. http://togogenome.org/gene/224914:BME_RS12100 ^@ http://purl.uniprot.org/uniprot/Q8YCY7 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/224914:BME_RS13995 ^@ http://purl.uniprot.org/uniprot/Q8YBV8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.|||Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/224914:BME_RS14615 ^@ http://purl.uniprot.org/uniprot/Q8YBJ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS03435 ^@ http://purl.uniprot.org/uniprot/Q8YHV3 ^@ Function|||Similarity ^@ Belongs to the CobU/CobP family.|||Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. http://togogenome.org/gene/224914:BME_RS12340 ^@ http://purl.uniprot.org/uniprot/Q8YCT8 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. http://togogenome.org/gene/224914:BME_RS05600 ^@ http://purl.uniprot.org/uniprot/Q8YGP1 ^@ Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. http://togogenome.org/gene/224914:BME_RS14340 ^@ http://purl.uniprot.org/uniprot/F8WJP4 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.|||Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/224914:BME_RS00910 ^@ http://purl.uniprot.org/uniprot/Q8YJ95 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/224914:BME_RS00310 ^@ http://purl.uniprot.org/uniprot/Q9L772 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).|||Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell inner membrane|||Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.|||Homotetramer. http://togogenome.org/gene/224914:BME_RS12655 ^@ http://purl.uniprot.org/uniprot/Q8YCM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Cell membrane|||Membrane|||Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/224914:BME_RS09720 ^@ http://purl.uniprot.org/uniprot/Q8YEB5 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/224914:BME_RS08215 ^@ http://purl.uniprot.org/uniprot/Q8YF73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UreF family.|||Cytoplasm|||Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.|||UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. http://togogenome.org/gene/224914:BME_RS01020 ^@ http://purl.uniprot.org/uniprot/P65790 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate 5-kinase family.|||Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS11425 ^@ http://purl.uniprot.org/uniprot/P0A3Q2 ^@ Function|||Similarity ^@ Belongs to the methylglyoxal synthase family.|||Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. http://togogenome.org/gene/224914:BME_RS14320 ^@ http://purl.uniprot.org/uniprot/P0A3U4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Omp25/RopB family.|||Cell outer membrane|||Major outer membrane protein associated with peptidoglycans. May function as a porin.|||Oligomeric. http://togogenome.org/gene/224914:BME_RS01455 ^@ http://purl.uniprot.org/uniprot/Q8YIY9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS08020 ^@ http://purl.uniprot.org/uniprot/Q8YFB1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.|||Cell membrane|||Monomer. http://togogenome.org/gene/224914:BME_RS11250 ^@ http://purl.uniprot.org/uniprot/Q8YDG0 ^@ Function|||Subunit ^@ E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).|||Homodimer. Part of the 2-oxoglutarate dehydrogenase (OGDH) complex composed of E1 (2-oxoglutarate dehydrogenase), E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase); the complex contains multiple copies of the three enzymatic components (E1, E2 and E3). http://togogenome.org/gene/224914:BME_RS15105 ^@ http://purl.uniprot.org/uniprot/Q8YB90 ^@ Cofactor|||Similarity ^@ Belongs to the ApbE family.|||Magnesium. Can also use manganese. http://togogenome.org/gene/224914:BME_RS04275 ^@ http://purl.uniprot.org/uniprot/Q8YHE5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 1 lipoyl cofactor covalently.|||Forms a 24-polypeptide structural core with octahedral symmetry.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/224914:BME_RS14905 ^@ http://purl.uniprot.org/uniprot/Q8YBD0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS14170 ^@ http://purl.uniprot.org/uniprot/Q8YBS3 ^@ Function|||Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate. http://togogenome.org/gene/224914:BME_RS10715 ^@ http://purl.uniprot.org/uniprot/Q8YDR6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial solute-binding protein SsuA/TauA family.|||Periplasm|||Probably part of an ABC transporter complex.|||The complex is composed of two ATP-binding proteins (BMEII0108), two transmembrane proteins (BMEII0107) and a solute-binding protein (BMEII0109). http://togogenome.org/gene/224914:BME_RS12345 ^@ http://purl.uniprot.org/uniprot/Q8YCT7 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/224914:BME_RS08785 ^@ http://purl.uniprot.org/uniprot/Q8YEV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmI family.|||Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS14725 ^@ http://purl.uniprot.org/uniprot/Q8YBH3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MinC family.|||Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.|||Interacts with MinD and FtsZ. http://togogenome.org/gene/224914:BME_RS01120 ^@ http://purl.uniprot.org/uniprot/Q8YJ58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/224914:BME_RS03885 ^@ http://purl.uniprot.org/uniprot/Q8YHL9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer. http://togogenome.org/gene/224914:BME_RS04435 ^@ http://purl.uniprot.org/uniprot/Q8YHB2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).|||Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1. http://togogenome.org/gene/224914:BME_RS01545 ^@ http://purl.uniprot.org/uniprot/Q8YIX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BioY family.|||Cell membrane http://togogenome.org/gene/224914:BME_RS04365 ^@ http://purl.uniprot.org/uniprot/Q8YHC7 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/224914:BME_RS11255 ^@ http://purl.uniprot.org/uniprot/Q7CNS7 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 5 family. http://togogenome.org/gene/224914:BME_RS07920 ^@ http://purl.uniprot.org/uniprot/Q8YFD3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.|||Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/224914:BME_RS08560 ^@ http://purl.uniprot.org/uniprot/Q8YF04 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/224914:BME_RS09300 ^@ http://purl.uniprot.org/uniprot/Q8YEK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-C family. DnaE2 subfamily.|||Cytoplasm|||DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. http://togogenome.org/gene/224914:BME_RS10805 ^@ http://purl.uniprot.org/uniprot/Q8YDP7 ^@ Similarity ^@ Belongs to the UPF0261 family. http://togogenome.org/gene/224914:BME_RS06290 ^@ http://purl.uniprot.org/uniprot/Q45321 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Omp25/RopB family.|||Cell outer membrane http://togogenome.org/gene/224914:BME_RS07480 ^@ http://purl.uniprot.org/uniprot/Q8YFM2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family. DXPS subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).|||Homodimer. http://togogenome.org/gene/224914:BME_RS11480 ^@ http://purl.uniprot.org/uniprot/P63913 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/224914:BME_RS10130 ^@ http://purl.uniprot.org/uniprot/Q8YE31 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||Allosterically activated by HslU binding.|||Belongs to the peptidase T1B family. HslV subfamily.|||Cytoplasm|||Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. http://togogenome.org/gene/224914:BME_RS10940 ^@ http://purl.uniprot.org/uniprot/Q8YDL8 ^@ Similarity ^@ Belongs to the virb1 family. http://togogenome.org/gene/224914:BME_RS00840 ^@ http://purl.uniprot.org/uniprot/Q8YJA9 ^@ Function|||Similarity ^@ Belongs to the uroporphyrinogen-III synthase family.|||Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. http://togogenome.org/gene/224914:BME_RS15265 ^@ http://purl.uniprot.org/uniprot/Q8YB57 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/224914:BME_RS04690 ^@ http://purl.uniprot.org/uniprot/Q8YH61 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase class-2 family.|||Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. http://togogenome.org/gene/224914:BME_RS03805 ^@ http://purl.uniprot.org/uniprot/Q8YHN5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). http://togogenome.org/gene/224914:BME_RS13080 ^@ http://purl.uniprot.org/uniprot/P61712 ^@ Function|||Induction|||Similarity|||Subunit ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity).|||Homodecamer, arranged as a dimer of pentamers.|||The two ribH genes may be differentially expressed during the Brucella infection cycle. Brucella would use RibH1 for flavin biosynthesis during the extracellular phase and RibH2 during intracellular growth (By similarity). http://togogenome.org/gene/224914:BME_RS01220 ^@ http://purl.uniprot.org/uniprot/Q8YJ37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/224914:BME_RS05805 ^@ http://purl.uniprot.org/uniprot/Q8YGK0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 3 family.|||Cell inner membrane|||Cell membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/224914:BME_RS00445 ^@ http://purl.uniprot.org/uniprot/Q8YJI8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/224914:BME_RS09255 ^@ http://purl.uniprot.org/uniprot/Q8YEL1 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RlmN family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.|||Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity. http://togogenome.org/gene/224914:BME_RS07205 ^@ http://purl.uniprot.org/uniprot/Q8YFT0 ^@ Function|||Similarity ^@ Belongs to the thioredoxin family. DsbA subfamily.|||May be required for disulfide bond formation in some proteins. http://togogenome.org/gene/224914:BME_RS05885 ^@ http://purl.uniprot.org/uniprot/Q8YGI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS05970 ^@ http://purl.uniprot.org/uniprot/Q8YGH3 ^@ Function|||Similarity ^@ Belongs to the NusB family.|||Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. http://togogenome.org/gene/224914:BME_RS00340 ^@ http://purl.uniprot.org/uniprot/P65744 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/224914:BME_RS03860 ^@ http://purl.uniprot.org/uniprot/Q8YHM4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/224914:BME_RS05795 ^@ http://purl.uniprot.org/uniprot/Q8YGK2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 30 kDa subunit family.|||Cell inner membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/224914:BME_RS00785 ^@ http://purl.uniprot.org/uniprot/Q8YJC0 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/224914:BME_RS02865 ^@ http://purl.uniprot.org/uniprot/P64255 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell inner membrane http://togogenome.org/gene/224914:BME_RS00035 ^@ http://purl.uniprot.org/uniprot/Q8YJS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/224914:BME_RS04200 ^@ http://purl.uniprot.org/uniprot/Q8YHG0 ^@ Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. http://togogenome.org/gene/224914:BME_RS01065 ^@ http://purl.uniprot.org/uniprot/Q8YJ70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0410 family.|||Membrane http://togogenome.org/gene/224914:BME_RS05395 ^@ http://purl.uniprot.org/uniprot/P0A4Q1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YajC family.|||Cell inner membrane|||Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).|||The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. http://togogenome.org/gene/224914:BME_RS13305 ^@ http://purl.uniprot.org/uniprot/Q8YC93 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/224914:BME_RS05315 ^@ http://purl.uniprot.org/uniprot/Q8YGU5 ^@ Function ^@ This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/224914:BME_RS08950 ^@ http://purl.uniprot.org/uniprot/P67586 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/224914:BME_RS07320 ^@ http://purl.uniprot.org/uniprot/Q8YFQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COX11/CtaG family.|||Cell inner membrane|||Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. http://togogenome.org/gene/224914:BME_RS11690 ^@ http://purl.uniprot.org/uniprot/Q8YD73 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MsrQ family.|||Binds 1 FMN per subunit.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|||Cell inner membrane|||Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).|||Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain. http://togogenome.org/gene/224914:BME_RS15040 ^@ http://purl.uniprot.org/uniprot/Q8YBA2 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/224914:BME_RS07485 ^@ http://purl.uniprot.org/uniprot/Q8YFM1 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/224914:BME_RS11340 ^@ http://purl.uniprot.org/uniprot/Q8YDE4 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2). http://togogenome.org/gene/224914:BME_RS05150 ^@ http://purl.uniprot.org/uniprot/Q8YGX6 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/224914:BME_RS12575 ^@ http://purl.uniprot.org/uniprot/Q8YCN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.|||Cell inner membrane|||Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (NikD and NikE), two transmembrane proteins (NikB and NikC) and a solute-binding protein (NikA). http://togogenome.org/gene/224914:BME_RS02630 ^@ http://purl.uniprot.org/uniprot/Q8YIB9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS12890 ^@ http://purl.uniprot.org/uniprot/Q7CNS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BA14k family.|||Cell membrane|||Has immunoglobulin-binding and hemagglutination properties, and can bind to mannose. Essential for virulence. May be involved in LPS biosynthesis or polysaccharide transport (By similarity). http://togogenome.org/gene/224914:BME_RS08720 ^@ http://purl.uniprot.org/uniprot/Q8YEX0 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/224914:BME_RS02435 ^@ http://purl.uniprot.org/uniprot/Q8YIF8 ^@ Similarity ^@ Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. http://togogenome.org/gene/224914:BME_RS14820 ^@ http://purl.uniprot.org/uniprot/Q8YBE7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS03250 ^@ http://purl.uniprot.org/uniprot/Q8YHY9 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/224914:BME_RS05075 ^@ http://purl.uniprot.org/uniprot/Q8YGZ1 ^@ Similarity ^@ Belongs to the YkuD family. http://togogenome.org/gene/224914:BME_RS14015 ^@ http://purl.uniprot.org/uniprot/Q8YBV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MetA family.|||Cytoplasm|||Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. http://togogenome.org/gene/224914:BME_RS11835 ^@ http://purl.uniprot.org/uniprot/Q8YD39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nlpA lipoprotein family.|||Membrane http://togogenome.org/gene/224914:BME_RS08315 ^@ http://purl.uniprot.org/uniprot/P62923 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/224914:BME_RS05180 ^@ http://purl.uniprot.org/uniprot/Q8YGW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. http://togogenome.org/gene/224914:BME_RS02010 ^@ http://purl.uniprot.org/uniprot/Q8YIP0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/224914:BME_RS12240 ^@ http://purl.uniprot.org/uniprot/Q8YCV9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.|||Cytoplasm|||Monomer. http://togogenome.org/gene/224914:BME_RS03495 ^@ http://purl.uniprot.org/uniprot/Q8YHU1 ^@ Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the CobB/CbiA family.|||Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source.|||Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and hydrogenobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.|||The a and c carboxylates of hydrogenobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CobB catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate. http://togogenome.org/gene/224914:BME_RS12505 ^@ http://purl.uniprot.org/uniprot/Q8YCQ4 ^@ Function|||Similarity ^@ Belongs to the mannonate dehydratase family.|||Catalyzes the dehydration of D-mannonate. http://togogenome.org/gene/224914:BME_RS02200 ^@ http://purl.uniprot.org/uniprot/Q8YIK5 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/224914:BME_RS09655 ^@ http://purl.uniprot.org/uniprot/Q8YEC8 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/224914:BME_RS03225 ^@ http://purl.uniprot.org/uniprot/Q8YHZ7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the urease beta subunit family.|||Cytoplasm|||Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. http://togogenome.org/gene/224914:BME_RS14430 ^@ http://purl.uniprot.org/uniprot/Q8YBN2 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/224914:BME_RS03835 ^@ http://purl.uniprot.org/uniprot/Q8YHM9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/224914:BME_RS07785 ^@ http://purl.uniprot.org/uniprot/Q8YFF8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Binds 1 copper ion per subunit, denoted as copper B.|||Binds 2 heme groups per subunit, denoted as high- and low-spin.|||Cell membrane|||Membrane http://togogenome.org/gene/224914:BME_RS09305 ^@ http://purl.uniprot.org/uniprot/Q8YEK1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS03035 ^@ http://purl.uniprot.org/uniprot/Q8YI36 ^@ Function|||Similarity ^@ Belongs to the dihydrofolate reductase family.|||Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. http://togogenome.org/gene/224914:BME_RS00100 ^@ http://purl.uniprot.org/uniprot/Q8YJR1 ^@ Function|||Similarity ^@ Belongs to the 3-oxoacid CoA-transferase family.|||CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. http://togogenome.org/gene/224914:BME_RS08170 ^@ http://purl.uniprot.org/uniprot/Q8YF82 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/224914:BME_RS01870 ^@ http://purl.uniprot.org/uniprot/Q8YIR3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the malate synthase family. GlcB subfamily.|||Cytoplasm|||Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.|||Monomer. http://togogenome.org/gene/224914:BME_RS07940 ^@ http://purl.uniprot.org/uniprot/Q8YFC9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pantothenate synthetase family.|||Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.|||Cytoplasm|||Homodimer.|||The reaction proceeds by a bi uni uni bi ping pong mechanism. http://togogenome.org/gene/224914:BME_RS00500 ^@ http://purl.uniprot.org/uniprot/Q8YJH5 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/224914:BME_RS11330 ^@ http://purl.uniprot.org/uniprot/Q8YDE6 ^@ Similarity ^@ Belongs to the SlyX family. http://togogenome.org/gene/224914:BME_RS15655 ^@ http://purl.uniprot.org/uniprot/Q8YAX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Cell membrane http://togogenome.org/gene/224914:BME_RS00655 ^@ http://purl.uniprot.org/uniprot/Q8YJE5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/224914:BME_RS12015 ^@ http://purl.uniprot.org/uniprot/Q8YD04 ^@ Function|||Similarity ^@ Belongs to the DadA oxidoreductase family.|||Oxidative deamination of D-amino acids. http://togogenome.org/gene/224914:BME_RS06310 ^@ http://purl.uniprot.org/uniprot/Q8YGA7 ^@ Similarity ^@ Belongs to the MoaD family. http://togogenome.org/gene/224914:BME_RS05060 ^@ http://purl.uniprot.org/uniprot/Q8YGZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0410 family.|||Membrane http://togogenome.org/gene/224914:BME_RS05220 ^@ http://purl.uniprot.org/uniprot/Q8YGW2 ^@ Function ^@ Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Seems to participate in the biosynthesis of the nitrogenase metalloclusters by providing the inorganic sulfur required for the Fe-S core formation. http://togogenome.org/gene/224914:BME_RS03505 ^@ http://purl.uniprot.org/uniprot/Q8YHT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobD/CbiB family.|||Cell membrane|||Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. http://togogenome.org/gene/224914:BME_RS13945 ^@ http://purl.uniprot.org/uniprot/Q8YBW8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS12185 ^@ http://purl.uniprot.org/uniprot/Q8YCX2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS07085 ^@ http://purl.uniprot.org/uniprot/F8WJX8 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.|||Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/224914:BME_RS01630 ^@ http://purl.uniprot.org/uniprot/F8WJN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ExbB/TolQ family.|||Cell inner membrane|||Membrane|||Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.|||The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer. http://togogenome.org/gene/224914:BME_RS14410 ^@ http://purl.uniprot.org/uniprot/Q8YBN6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system (By similarity).|||The complex is composed of two ATP-binding proteins (BMEII0863 and BMEII0864), two transmembrane proteins (BMEII0860 and BMEII0861) and a solute-binding protein (BMEII0859). http://togogenome.org/gene/224914:BME_RS07780 ^@ http://purl.uniprot.org/uniprot/Q8YFF9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Fur family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/224914:BME_RS04680 ^@ http://purl.uniprot.org/uniprot/Q8YH64 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.|||Cell inner membrane|||Homotetramer.|||Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine. http://togogenome.org/gene/224914:BME_RS03440 ^@ http://purl.uniprot.org/uniprot/Q8YHV2 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily. http://togogenome.org/gene/224914:BME_RS13445 ^@ http://purl.uniprot.org/uniprot/Q8YC67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.|||Belongs to the RNR ribonuclease family. RNase R subfamily.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS01420 ^@ http://purl.uniprot.org/uniprot/Q8YIZ5 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/224914:BME_RS10975 ^@ http://purl.uniprot.org/uniprot/Q8YDL1 ^@ Function|||Similarity ^@ Belongs to the FlgD family.|||Required for flagellar hook formation. May act as a scaffolding protein. http://togogenome.org/gene/224914:BME_RS14565 ^@ http://purl.uniprot.org/uniprot/P0A326 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the catalase family.|||Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.|||Homotetramer.|||Periplasm http://togogenome.org/gene/224914:BME_RS08840 ^@ http://purl.uniprot.org/uniprot/Q8YEU5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/224914:BME_RS07730 ^@ http://purl.uniprot.org/uniprot/Q8YFH1 ^@ Similarity ^@ Belongs to the YfgM family. http://togogenome.org/gene/224914:BME_RS03725 ^@ http://purl.uniprot.org/uniprot/Q8YHQ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/224914:BME_RS15705 ^@ http://purl.uniprot.org/uniprot/Q8YAW9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS05440 ^@ http://purl.uniprot.org/uniprot/P66887 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatA/E family.|||Cell inner membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.|||The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. http://togogenome.org/gene/224914:BME_RS02570 ^@ http://purl.uniprot.org/uniprot/Q8YID2 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/224914:BME_RS08810 ^@ http://purl.uniprot.org/uniprot/Q8YEV2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNase PH family.|||Homohexameric ring arranged as a trimer of dimers.|||Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. http://togogenome.org/gene/224914:BME_RS08320 ^@ http://purl.uniprot.org/uniprot/Q8YF55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family. YhdE subfamily.|||Cytoplasm|||Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/224914:BME_RS05755 ^@ http://purl.uniprot.org/uniprot/Q8YGL0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Cell inner membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/224914:BME_RS09570 ^@ http://purl.uniprot.org/uniprot/Q8YEE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 5 family.|||Periplasm http://togogenome.org/gene/224914:BME_RS04130 ^@ http://purl.uniprot.org/uniprot/Q8YHH3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer. http://togogenome.org/gene/224914:BME_RS02080 ^@ http://purl.uniprot.org/uniprot/Q8YIM6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Functions as a polar differentiation marker. Essential protein that, by localizing in the old pole of dividing cells, controls cell division and maturation, probably through control of DivK phosphorylation status and cellular distribution, which in turn regulates CtrA, a transcriptional regulator of the minB operon. The asymmetrical localization of this protein is probably required for cells to enter a new division cycle (By similarity).|||Interacts with DivK. http://togogenome.org/gene/224914:BME_RS06750 ^@ http://purl.uniprot.org/uniprot/Q8YG20 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/224914:BME_RS03715 ^@ http://purl.uniprot.org/uniprot/Q8YHQ2 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/224914:BME_RS08185 ^@ http://purl.uniprot.org/uniprot/Q8YF78 ^@ PTM|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Carbamylation allows a single lysine to coordinate two divalent metal cations. http://togogenome.org/gene/224914:BME_RS00990 ^@ http://purl.uniprot.org/uniprot/Q8YJ85 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/224914:BME_RS08625 ^@ http://purl.uniprot.org/uniprot/Q8YEZ1 ^@ Similarity ^@ Belongs to the thiamine-phosphate synthase family. http://togogenome.org/gene/224914:BME_RS00255 ^@ http://purl.uniprot.org/uniprot/Q8YJM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.|||Cell inner membrane|||Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. http://togogenome.org/gene/224914:BME_RS09715 ^@ http://purl.uniprot.org/uniprot/Q8YEB6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/224914:BME_RS02810 ^@ http://purl.uniprot.org/uniprot/Q8YI83 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 25 family. http://togogenome.org/gene/224914:BME_RS03140 ^@ http://purl.uniprot.org/uniprot/Q8YI15 ^@ Similarity ^@ Belongs to the PhzF family. http://togogenome.org/gene/224914:BME_RS03095 ^@ http://purl.uniprot.org/uniprot/Q8YI24 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP synthase family.|||Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.|||Cytoplasm|||Homooctamer; tetramer of dimers. http://togogenome.org/gene/224914:BME_RS03735 ^@ http://purl.uniprot.org/uniprot/P0A468 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/224914:BME_RS02195 ^@ http://purl.uniprot.org/uniprot/Q8YIK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Probably part of an ABC transporter complex that could be involved in peptide import. Probably responsible for energy coupling to the transport system. http://togogenome.org/gene/224914:BME_RS06020 ^@ http://purl.uniprot.org/uniprot/Q8YGG2 ^@ Similarity|||Subunit ^@ Belongs to the ALAD family.|||Homooctamer. http://togogenome.org/gene/224914:BME_RS04070 ^@ http://purl.uniprot.org/uniprot/Q8YHI3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ClpS family.|||Binds to the N-terminal domain of the chaperone ClpA.|||Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation. http://togogenome.org/gene/224914:BME_RS06710 ^@ http://purl.uniprot.org/uniprot/Q8YG29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmE/CycJ family.|||Cell inner membrane|||Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. http://togogenome.org/gene/224914:BME_RS09695 ^@ http://purl.uniprot.org/uniprot/Q8YEC0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. http://togogenome.org/gene/224914:BME_RS09580 ^@ http://purl.uniprot.org/uniprot/Q8YEE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Cell membrane http://togogenome.org/gene/224914:BME_RS04855 ^@ http://purl.uniprot.org/uniprot/Q8YH30 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose 5-phosphate isomerase family.|||Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.|||Homodimer. http://togogenome.org/gene/224914:BME_RS08210 ^@ http://purl.uniprot.org/uniprot/Q7CNT4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.|||Cytoplasm|||Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.|||Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. http://togogenome.org/gene/224914:BME_RS10095 ^@ http://purl.uniprot.org/uniprot/P63808 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic pantothenate kinase family.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS15130 ^@ http://purl.uniprot.org/uniprot/Q8YB85 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/224914:BME_RS05775 ^@ http://purl.uniprot.org/uniprot/Q8YGK6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the complex I 75 kDa subunit family.|||Binds 1 [2Fe-2S] cluster per subunit.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/224914:BME_RS03825 ^@ http://purl.uniprot.org/uniprot/Q8YHN1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/224914:BME_RS09690 ^@ http://purl.uniprot.org/uniprot/Q8YEC1 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/224914:BME_RS12290 ^@ http://purl.uniprot.org/uniprot/Q8YCU9 ^@ Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/224914:BME_RS09925 ^@ http://purl.uniprot.org/uniprot/Q8YE73 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/224914:BME_RS09240 ^@ http://purl.uniprot.org/uniprot/Q8YEL3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS15270 ^@ http://purl.uniprot.org/uniprot/Q8YB56 ^@ Function|||Similarity ^@ Belongs to the ribF family.|||Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD. http://togogenome.org/gene/224914:BME_RS03330 ^@ http://purl.uniprot.org/uniprot/Q8YHX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic sulfate-binding protein family.|||Periplasm http://togogenome.org/gene/224914:BME_RS15430 ^@ http://purl.uniprot.org/uniprot/Q8YB24 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/224914:BME_RS11405 ^@ http://purl.uniprot.org/uniprot/Q8YDC9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.|||Homodimer. http://togogenome.org/gene/224914:BME_RS11230 ^@ http://purl.uniprot.org/uniprot/Q8YDG4 ^@ Similarity ^@ Belongs to the peptidase S45 family. http://togogenome.org/gene/224914:BME_RS10685 ^@ http://purl.uniprot.org/uniprot/Q8YDS2 ^@ Function|||Similarity ^@ Belongs to the leucine-binding protein family.|||Component of an amino-acid transport system. http://togogenome.org/gene/224914:BME_RS05115 ^@ http://purl.uniprot.org/uniprot/Q8YGY3 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 3 family. http://togogenome.org/gene/224914:BME_RS14835 ^@ http://purl.uniprot.org/uniprot/Q8YBE4 ^@ Caution|||Function|||Similarity ^@ Belongs to the UbiX/PAD1 family.|||Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/224914:BME_RS15310 ^@ http://purl.uniprot.org/uniprot/Q8YB48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.|||Cell inner membrane|||Intake of glucose and galactose. http://togogenome.org/gene/224914:BME_RS07450 ^@ http://purl.uniprot.org/uniprot/Q8YFM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/224914:BME_RS03510 ^@ http://purl.uniprot.org/uniprot/Q8YHT8 ^@ Function ^@ Component of an amino-acid transport system. http://togogenome.org/gene/224914:BME_RS09920 ^@ http://purl.uniprot.org/uniprot/Q8YE74 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/224914:BME_RS14715 ^@ http://purl.uniprot.org/uniprot/P65361 ^@ Function|||Similarity ^@ Belongs to the MinE family.|||Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. http://togogenome.org/gene/224914:BME_RS07830 ^@ http://purl.uniprot.org/uniprot/Q8YFF1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. http://togogenome.org/gene/224914:BME_RS13400 ^@ http://purl.uniprot.org/uniprot/Q8YC76 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DNA polymerase type-Y family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Monomer.|||Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. http://togogenome.org/gene/224914:BME_RS02885 ^@ http://purl.uniprot.org/uniprot/P65468 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS06050 ^@ http://purl.uniprot.org/uniprot/Q8YGF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase D family.|||Cytoplasm|||Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides. http://togogenome.org/gene/224914:BME_RS07905 ^@ http://purl.uniprot.org/uniprot/Q8YFD7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Cell inner membrane|||Multidrug efflux pump. http://togogenome.org/gene/224914:BME_RS02070 ^@ http://purl.uniprot.org/uniprot/Q8YIM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Cell membrane http://togogenome.org/gene/224914:BME_RS14025 ^@ http://purl.uniprot.org/uniprot/Q8YBV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/224914:BME_RS08820 ^@ http://purl.uniprot.org/uniprot/Q8YEV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/224914:BME_RS07385 ^@ http://purl.uniprot.org/uniprot/Q8YFP2 ^@ Similarity ^@ Belongs to the fabD family. http://togogenome.org/gene/224914:BME_RS05740 ^@ http://purl.uniprot.org/uniprot/Q8YGL3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 2 family.|||Cell inner membrane|||Membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/224914:BME_RS10710 ^@ http://purl.uniprot.org/uniprot/Q8YDR7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Probably part of an ABC transporter complex. Probably Responsible for energy coupling to the transport system (Probable).|||The complex is composed of two ATP-binding proteins (BMEII0108), two transmembrane proteins (BMEII0107) and a solute-binding protein (BMEII0109). http://togogenome.org/gene/224914:BME_RS06545 ^@ http://purl.uniprot.org/uniprot/Q8YG59 ^@ Similarity ^@ Belongs to the virb1 family. http://togogenome.org/gene/224914:BME_RS02945 ^@ http://purl.uniprot.org/uniprot/Q8YI53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. PrmA family.|||Cytoplasm|||Methylates ribosomal protein L11. http://togogenome.org/gene/224914:BME_RS11780 ^@ http://purl.uniprot.org/uniprot/Q8YD52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PNT beta subunit family.|||Cell inner membrane|||Membrane|||The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. http://togogenome.org/gene/224914:BME_RS11040 ^@ http://purl.uniprot.org/uniprot/Q8YDJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 9 family.|||Part of the ATP-binding cassette (ABC) system ZnuABC involved in zinc import (By similarity). Binds zinc with high affinity and specificity and delivers it to the membrane permease for translocation into the cytoplasm (By similarity). Required for survival and normal growth under low Zn (2+) concentrations (By similarity). Also required for virulence and intracellular growth in host cells (By similarity).|||Periplasm http://togogenome.org/gene/224914:BME_RS00695 ^@ http://purl.uniprot.org/uniprot/Q8YJD9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerC subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/224914:BME_RS05945 ^@ http://purl.uniprot.org/uniprot/Q8YGH8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsX family.|||Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.|||Cytoplasm|||Homodimer. Probably interacts with PlsY. http://togogenome.org/gene/224914:BME_RS12960 ^@ http://purl.uniprot.org/uniprot/Q8YCG3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Fe(3+) ion importer (TC 3.A.1.10) family.|||Cell inner membrane|||Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (FbpC), two transmembrane proteins (FbpB) and a solute-binding protein (FbpA). http://togogenome.org/gene/224914:BME_RS04840 ^@ http://purl.uniprot.org/uniprot/Q8YH33 ^@ Cofactor|||Similarity ^@ Belongs to the class-II DAHP synthase family.|||Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions. http://togogenome.org/gene/224914:BME_RS01555 ^@ http://purl.uniprot.org/uniprot/P67173 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS01860 ^@ http://purl.uniprot.org/uniprot/Q8YIR5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoH subfamily.|||Cytoplasm|||Interacts with the RNA polymerase core enzyme.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. http://togogenome.org/gene/224914:BME_RS03880 ^@ http://purl.uniprot.org/uniprot/Q8YHM0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell inner membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/224914:BME_RS10980 ^@ http://purl.uniprot.org/uniprot/Q8YDL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliQ/MopD/SpaQ family.|||Cell membrane|||Membrane|||Role in flagellar biosynthesis. http://togogenome.org/gene/224914:BME_RS05860 ^@ http://purl.uniprot.org/uniprot/Q8YGJ2 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/224914:BME_RS00470 ^@ http://purl.uniprot.org/uniprot/Q8YJI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal stress protein A family.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS11940 ^@ http://purl.uniprot.org/uniprot/Q8YD19 ^@ Similarity ^@ Belongs to the KHG/KDPG aldolase family. http://togogenome.org/gene/224914:BME_RS03110 ^@ http://purl.uniprot.org/uniprot/Q8YI21 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. http://togogenome.org/gene/224914:BME_RS07695 ^@ http://purl.uniprot.org/uniprot/Q8YFH7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell inner membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains. http://togogenome.org/gene/224914:BME_RS14230 ^@ http://purl.uniprot.org/uniprot/F8WJP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/224914:BME_RS09900 ^@ http://purl.uniprot.org/uniprot/Q8YE77 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/224914:BME_RS06955 ^@ http://purl.uniprot.org/uniprot/Q8YFY0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Binds 2 potassium ions per subunit.|||Dimer of dimers.|||Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid. http://togogenome.org/gene/224914:BME_RS10330 ^@ http://purl.uniprot.org/uniprot/Q8YDZ4 ^@ Similarity ^@ Belongs to the TrbE/VirB4 family. http://togogenome.org/gene/224914:BME_RS00390 ^@ http://purl.uniprot.org/uniprot/Q8YJJ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/224914:BME_RS10970 ^@ http://purl.uniprot.org/uniprot/Q8YDL2 ^@ Caution|||Function|||Similarity ^@ Belongs to the FlbT family.|||Brucella species display species-specific inactivation of flagellar genes and are consequently nonmotile.|||Has a post-transcriptional repressor function in flagellum biogenesis. Associates with the 5'-UTR of fljK mRNA and promotes its degradation. http://togogenome.org/gene/224914:BME_RS03070 ^@ http://purl.uniprot.org/uniprot/Q8YI29 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Monomer. http://togogenome.org/gene/224914:BME_RS01745 ^@ http://purl.uniprot.org/uniprot/P64004 ^@ Function|||Similarity ^@ Belongs to the dUTPase family.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/224914:BME_RS12085 ^@ http://purl.uniprot.org/uniprot/Q8YCZ0 ^@ Function|||Similarity ^@ Belongs to the PurU family.|||Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). http://togogenome.org/gene/224914:BME_RS10575 ^@ http://purl.uniprot.org/uniprot/Q7CNT0 ^@ Cofactor ^@ Binds 1 phosphopantetheine covalently. http://togogenome.org/gene/224914:BME_RS03930 ^@ http://purl.uniprot.org/uniprot/P65975 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS07495 ^@ http://purl.uniprot.org/uniprot/Q8YFL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0410 family.|||Membrane http://togogenome.org/gene/224914:BME_RS10740 ^@ http://purl.uniprot.org/uniprot/Q8YDR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell inner membrane|||Cell membrane http://togogenome.org/gene/224914:BME_RS04195 ^@ http://purl.uniprot.org/uniprot/Q8YHG1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase S24 family.|||Homodimer.|||Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. http://togogenome.org/gene/224914:BME_RS12815 ^@ http://purl.uniprot.org/uniprot/Q8YCI9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M81 family.|||Binds 1 zinc ion per subunit.|||Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC). http://togogenome.org/gene/224914:BME_RS00515 ^@ http://purl.uniprot.org/uniprot/Q8YJH2 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/224914:BME_RS09155 ^@ http://purl.uniprot.org/uniprot/Q8YEM9 ^@ Similarity ^@ Belongs to the thioredoxin family. DsbE subfamily. http://togogenome.org/gene/224914:BME_RS01650 ^@ http://purl.uniprot.org/uniprot/P0A3S7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Pal lipoprotein family.|||Cell outer membrane|||Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.|||The N-terminus is blocked.|||The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer. http://togogenome.org/gene/224914:BME_RS14515 ^@ http://purl.uniprot.org/uniprot/Q8YBL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.|||Membrane http://togogenome.org/gene/224914:BME_RS07815 ^@ http://purl.uniprot.org/uniprot/Q8YFF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/224914:BME_RS02860 ^@ http://purl.uniprot.org/uniprot/Q8YI70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurF subfamily.|||Cytoplasm|||Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. http://togogenome.org/gene/224914:BME_RS03600 ^@ http://purl.uniprot.org/uniprot/Q8YHS2 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/224914:BME_RS15000 ^@ http://purl.uniprot.org/uniprot/Q8YBB0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS04110 ^@ http://purl.uniprot.org/uniprot/Q8YHH6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/224914:BME_RS08895 ^@ http://purl.uniprot.org/uniprot/Q8YET3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial histone-like protein family.|||Heterodimer of an alpha and a beta chain.|||This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. http://togogenome.org/gene/224914:BME_RS11035 ^@ http://purl.uniprot.org/uniprot/Q8YDJ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.|||Cell inner membrane|||Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (ZnuC), two transmembrane proteins (ZnuB) and a solute-binding protein (ZnuA). http://togogenome.org/gene/224914:BME_RS07135 ^@ http://purl.uniprot.org/uniprot/Q8YFU4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS15920 ^@ http://purl.uniprot.org/uniprot/P66286 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/224914:BME_RS15415 ^@ http://purl.uniprot.org/uniprot/Q8YB27 ^@ Similarity ^@ Belongs to the HpcH/HpaI aldolase family. http://togogenome.org/gene/224914:BME_RS07275 ^@ http://purl.uniprot.org/uniprot/Q8YFR6 ^@ Similarity ^@ Belongs to the UPF0301 (AlgH) family. http://togogenome.org/gene/224914:BME_RS04205 ^@ http://purl.uniprot.org/uniprot/Q8YHF9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/224914:BME_RS09575 ^@ http://purl.uniprot.org/uniprot/Q8YEE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 5 family.|||Periplasm http://togogenome.org/gene/224914:BME_RS07150 ^@ http://purl.uniprot.org/uniprot/Q8YFU1 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.|||Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).|||HIU hydrolysis also occurs spontaneously, but more slowly.|||Homotetramer. http://togogenome.org/gene/224914:BME_RS08165 ^@ http://purl.uniprot.org/uniprot/Q8YF83 ^@ Similarity ^@ Belongs to the dihydropyrimidine dehydrogenase family. http://togogenome.org/gene/224914:BME_RS02500 ^@ http://purl.uniprot.org/uniprot/Q8YIE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BA14k family.|||Cell membrane|||Has immunoglobulin-binding and hemagglutination properties, and can bind to mannose. Essential for virulence. May be involved in LPS biosynthesis or polysaccharide transport.|||Membrane http://togogenome.org/gene/224914:BME_RS01200 ^@ http://purl.uniprot.org/uniprot/Q8YJ42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transaldolase family. Type 3B subfamily.|||Cytoplasm|||Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. http://togogenome.org/gene/224914:BME_RS06650 ^@ http://purl.uniprot.org/uniprot/Q8YG41 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family. http://togogenome.org/gene/224914:BME_RS10610 ^@ http://purl.uniprot.org/uniprot/Q8YDT9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/224914:BME_RS15160 ^@ http://purl.uniprot.org/uniprot/Q8YB79 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/224914:BME_RS12255 ^@ http://purl.uniprot.org/uniprot/Q8YCV6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FBPase class 1 family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/224914:BME_RS02915 ^@ http://purl.uniprot.org/uniprot/Q8YI59 ^@ Function|||Similarity ^@ Belongs to the LpxC family.|||Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. http://togogenome.org/gene/224914:BME_RS06920 ^@ http://purl.uniprot.org/uniprot/Q8YFY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/224914:BME_RS08230 ^@ http://purl.uniprot.org/uniprot/Q7CNT2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the urease beta subunit family.|||Cytoplasm|||Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. http://togogenome.org/gene/224914:BME_RS08110 ^@ http://purl.uniprot.org/uniprot/Q8YF93 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/224914:BME_RS13940 ^@ http://purl.uniprot.org/uniprot/Q8YBW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.|||Cell membrane|||Membrane http://togogenome.org/gene/224914:BME_RS04300 ^@ http://purl.uniprot.org/uniprot/Q8YHE0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/224914:BME_RS07395 ^@ http://purl.uniprot.org/uniprot/P66453 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6. http://togogenome.org/gene/224914:BME_RS15555 ^@ http://purl.uniprot.org/uniprot/Q8YAZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GtrA family.|||Membrane http://togogenome.org/gene/224914:BME_RS11160 ^@ http://purl.uniprot.org/uniprot/Q8YDH9 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/224914:BME_RS00745 ^@ http://purl.uniprot.org/uniprot/Q8YJC9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/224914:BME_RS03800 ^@ http://purl.uniprot.org/uniprot/P66489 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/224914:BME_RS14195 ^@ http://purl.uniprot.org/uniprot/Q8YBR9 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/224914:BME_RS07885 ^@ http://purl.uniprot.org/uniprot/Q8YFE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP transporter small permease family.|||Cell inner membrane|||Membrane|||Part of the tripartite ATP-independent periplasmic (TRAP) transport system.|||The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins. http://togogenome.org/gene/224914:BME_RS00665 ^@ http://purl.uniprot.org/uniprot/F8WJX2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 1 lipoyl cofactor covalently.|||E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). http://togogenome.org/gene/224914:BME_RS01635 ^@ http://purl.uniprot.org/uniprot/Q8YIV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/224914:BME_RS13850 ^@ http://purl.uniprot.org/uniprot/Q8YBY8 ^@ Function|||Similarity ^@ Belongs to the BCKDHA family.|||The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/224914:BME_RS03820 ^@ http://purl.uniprot.org/uniprot/P66164 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/224914:BME_RS06355 ^@ http://purl.uniprot.org/uniprot/Q8YG98 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/224914:BME_RS04745 ^@ http://purl.uniprot.org/uniprot/Q8YH50 ^@ Function|||Similarity ^@ Belongs to the HPPK family.|||Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway. http://togogenome.org/gene/224914:BME_RS02675 ^@ http://purl.uniprot.org/uniprot/P0A3U8 ^@ Subcellular Location Annotation ^@ Periplasm http://togogenome.org/gene/224914:BME_RS02975 ^@ http://purl.uniprot.org/uniprot/Q8YI47 ^@ Similarity ^@ Belongs to the UPF0303 family. http://togogenome.org/gene/224914:BME_RS09765 ^@ http://purl.uniprot.org/uniprot/Q8YEA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.|||Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.|||Cell inner membrane http://togogenome.org/gene/224914:BME_RS10005 ^@ http://purl.uniprot.org/uniprot/Q8YE59 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/224914:BME_RS14625 ^@ http://purl.uniprot.org/uniprot/Q8YBJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HdeA family.|||Periplasm|||Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non-specifically the aggregation of denaturated periplasmic proteins. http://togogenome.org/gene/224914:BME_RS03615 ^@ http://purl.uniprot.org/uniprot/Q8YHR9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the D-alanine--D-alanine ligase family.|||Binds 2 magnesium or manganese ions per subunit.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/224914:BME_RS13860 ^@ http://purl.uniprot.org/uniprot/Q8YBY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell inner membrane|||Membrane http://togogenome.org/gene/224914:BME_RS05230 ^@ http://purl.uniprot.org/uniprot/Q8YGW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/224914:BME_RS09685 ^@ http://purl.uniprot.org/uniprot/P64103 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thioester dehydratase family. FabA subfamily.|||Cytoplasm|||Homodimer.|||Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. http://togogenome.org/gene/224914:BME_RS03870 ^@ http://purl.uniprot.org/uniprot/Q8YHM2 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/224914:BME_RS12795 ^@ http://purl.uniprot.org/uniprot/Q8YCJ5 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/224914:BME_RS06480 ^@ http://purl.uniprot.org/uniprot/P63464 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.