http://togogenome.org/gene/243274:THEMA_RS08275 ^@ http://purl.uniprot.org/uniprot/Q9X0S2|||http://purl.uniprot.org/uniprot/R4NSB2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 42 family. http://togogenome.org/gene/243274:THEMA_RS05250 ^@ http://purl.uniprot.org/uniprot/G4FGG9|||http://purl.uniprot.org/uniprot/Q9X2A2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS01280 ^@ http://purl.uniprot.org/uniprot/G4FDE7 ^@ Similarity ^@ Belongs to the MotB family. http://togogenome.org/gene/243274:THEMA_RS01930 ^@ http://purl.uniprot.org/uniprot/Q9WZ19|||http://purl.uniprot.org/uniprot/R4NQH5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/243274:THEMA_RS04780 ^@ http://purl.uniprot.org/uniprot/Q9X2I3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings (By similarity).|||Belongs to the ParA family. MinD subfamily.|||Cell membrane|||Interacts with MinC and FtsZ. http://togogenome.org/gene/243274:THEMA_RS03240 ^@ http://purl.uniprot.org/uniprot/G4FHK7|||http://purl.uniprot.org/uniprot/Q9WYC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyl phosphate reductase family.|||Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS04335 ^@ http://purl.uniprot.org/uniprot/G4FH00 ^@ Similarity ^@ Belongs to the FlgM family. http://togogenome.org/gene/243274:THEMA_RS00845 ^@ http://purl.uniprot.org/uniprot/Q9WZM0|||http://purl.uniprot.org/uniprot/R4NZF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS04505 ^@ http://purl.uniprot.org/uniprot/Q9WXQ8|||http://purl.uniprot.org/uniprot/R4NX35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.|||Cell inner membrane|||Membrane|||Probable transporter of a GTP-driven Fe(2+) uptake system. http://togogenome.org/gene/243274:THEMA_RS00955 ^@ http://purl.uniprot.org/uniprot/G4FD83|||http://purl.uniprot.org/uniprot/Q9WZJ9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS06965 ^@ http://purl.uniprot.org/uniprot/G4FFI8|||http://purl.uniprot.org/uniprot/Q9X1G4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/243274:THEMA_RS03875 ^@ http://purl.uniprot.org/uniprot/Q9WY21|||http://purl.uniprot.org/uniprot/R4NPI6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS06700 ^@ http://purl.uniprot.org/uniprot/G4FFP1|||http://purl.uniprot.org/uniprot/P38526 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/243274:THEMA_RS03260 ^@ http://purl.uniprot.org/uniprot/Q9WYC5 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Short' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.|||Cytoplasm|||Homodimer.|||Mg(2+) can be partially replaced by Co(2+), Mn(2+) and Ni(2+).|||Non-allosteric. http://togogenome.org/gene/243274:THEMA_RS02070 ^@ http://purl.uniprot.org/uniprot/G4FDU9|||http://purl.uniprot.org/uniprot/Q9WYZ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP (By similarity).|||A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.|||Belongs to the ClpX chaperone family. HslU subfamily.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS06350 ^@ http://purl.uniprot.org/uniprot/G4FFV9|||http://purl.uniprot.org/uniprot/Q9X1Q7 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/243274:THEMA_RS09090 ^@ http://purl.uniprot.org/uniprot/G4FEW2|||http://purl.uniprot.org/uniprot/Q9X0C6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/243274:THEMA_RS05730 ^@ http://purl.uniprot.org/uniprot/G4FG75|||http://purl.uniprot.org/uniprot/Q9X214 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase subunit omega family.|||Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).|||Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription (By similarity).|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/243274:THEMA_RS06715 ^@ http://purl.uniprot.org/uniprot/G4FFN8|||http://purl.uniprot.org/uniprot/P38518 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/243274:THEMA_RS07940 ^@ http://purl.uniprot.org/uniprot/Q9X0Z0|||http://purl.uniprot.org/uniprot/R4P0T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS02880 ^@ http://purl.uniprot.org/uniprot/G4FHS6|||http://purl.uniprot.org/uniprot/P80099 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 13 family.|||Binds 1 Ca(2+) ion per subunit.|||Cytoplasm|||Monomer. http://togogenome.org/gene/243274:THEMA_RS08820 ^@ http://purl.uniprot.org/uniprot/Q9X0H4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS07080 ^@ http://purl.uniprot.org/uniprot/Q9X1E4|||http://purl.uniprot.org/uniprot/R4NRC6 ^@ Activity Regulation|||Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Inhibited by fructose 1,6-bisphosphate (FBP).|||Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate. http://togogenome.org/gene/243274:THEMA_RS08765 ^@ http://purl.uniprot.org/uniprot/Q9X0I4|||http://purl.uniprot.org/uniprot/R4NQH7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS05580 ^@ http://purl.uniprot.org/uniprot/Q9X243|||http://purl.uniprot.org/uniprot/R4NS90 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit.|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS08850 ^@ http://purl.uniprot.org/uniprot/G4FER4|||http://purl.uniprot.org/uniprot/O33926 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/243274:THEMA_RS05040 ^@ http://purl.uniprot.org/uniprot/Q9X2E3|||http://purl.uniprot.org/uniprot/R4P2B5 ^@ Function|||Similarity ^@ Belongs to the band 7/mec-2 family. HflC subfamily.|||HflC and HflK could regulate a protease. http://togogenome.org/gene/243274:THEMA_RS03235 ^@ http://purl.uniprot.org/uniprot/G4FHK8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate 5-kinase family.|||Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS03555 ^@ http://purl.uniprot.org/uniprot/Q9WY72|||http://purl.uniprot.org/uniprot/R4NXP9 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/243274:THEMA_RS07355 ^@ http://purl.uniprot.org/uniprot/Q9X198|||http://purl.uniprot.org/uniprot/R4P0S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS07530 ^@ http://purl.uniprot.org/uniprot/G4FF81|||http://purl.uniprot.org/uniprot/Q9X166 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm|||Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. http://togogenome.org/gene/243274:THEMA_RS03780 ^@ http://purl.uniprot.org/uniprot/Q9WY33|||http://purl.uniprot.org/uniprot/R4NXH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/243274:THEMA_RS00360 ^@ http://purl.uniprot.org/uniprot/G4FCW9|||http://purl.uniprot.org/uniprot/Q9WZV9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer (Ref.3). Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/243274:THEMA_RS04665 ^@ http://purl.uniprot.org/uniprot/Q56318 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/243274:THEMA_RS08615 ^@ http://purl.uniprot.org/uniprot/G4FEL8|||http://purl.uniprot.org/uniprot/Q9X0L4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family.|||Cytoplasm|||Homotetramer.|||In addition to acetyl-CoA (100%), the enzyme accepts propionyl-CoA (60%) and butyryl-CoA (30%). http://togogenome.org/gene/243274:THEMA_RS00860 ^@ http://purl.uniprot.org/uniprot/Q9WZL7|||http://purl.uniprot.org/uniprot/R4NZ58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum|||Belongs to the bacterial flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.|||Secreted http://togogenome.org/gene/243274:THEMA_RS05885 ^@ http://purl.uniprot.org/uniprot/G4FG47|||http://purl.uniprot.org/uniprot/Q9X1Y8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit.|||Binds 2 divalent ions per subunit.|||Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.|||Cytoplasm|||Homotetramer; dimer of dimers. http://togogenome.org/gene/243274:THEMA_RS01780 ^@ http://purl.uniprot.org/uniprot/Q9WZ47|||http://purl.uniprot.org/uniprot/R4NQK8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS07520 ^@ http://purl.uniprot.org/uniprot/Q9X168|||http://purl.uniprot.org/uniprot/R4P2Z3 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/243274:THEMA_RS07310 ^@ http://purl.uniprot.org/uniprot/G4FFC3|||http://purl.uniprot.org/uniprot/Q9X1A7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CoaE family.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS05485 ^@ http://purl.uniprot.org/uniprot/G4FGC3 ^@ Function|||Similarity ^@ Belongs to the PNP/MTAP phosphorylase family.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/243274:THEMA_RS00595 ^@ http://purl.uniprot.org/uniprot/Q9WZR8|||http://purl.uniprot.org/uniprot/R4NZJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS05585 ^@ http://purl.uniprot.org/uniprot/Q9X242 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/243274:THEMA_RS01225 ^@ http://purl.uniprot.org/uniprot/G4FDD6|||http://purl.uniprot.org/uniprot/P17721 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD (PubMed:2271518). The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG (By similarity).|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/243274:THEMA_RS07350 ^@ http://purl.uniprot.org/uniprot/G4FFB5|||http://purl.uniprot.org/uniprot/Q9X199 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS08145 ^@ http://purl.uniprot.org/uniprot/Q9X0U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS03245 ^@ http://purl.uniprot.org/uniprot/G4FHK6|||http://purl.uniprot.org/uniprot/Q9WYC8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/243274:THEMA_RS05195 ^@ http://purl.uniprot.org/uniprot/G4FGH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRISPR system Cmr5 family.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS06250 ^@ http://purl.uniprot.org/uniprot/Q9X1S5|||http://purl.uniprot.org/uniprot/R4NTE3 ^@ Similarity ^@ Belongs to the intimin/invasin family. http://togogenome.org/gene/243274:THEMA_RS06335 ^@ http://purl.uniprot.org/uniprot/G4FFW2|||http://purl.uniprot.org/uniprot/Q9X1R0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS01560 ^@ http://purl.uniprot.org/uniprot/Q9WZ89|||http://purl.uniprot.org/uniprot/R4NP74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS04875 ^@ http://purl.uniprot.org/uniprot/Q9X2G6|||http://purl.uniprot.org/uniprot/R4NSK1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 38 family. http://togogenome.org/gene/243274:THEMA_RS07665 ^@ http://purl.uniprot.org/uniprot/Q9X144|||http://purl.uniprot.org/uniprot/R4NR38 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS00045 ^@ http://purl.uniprot.org/uniprot/Q9X020|||http://purl.uniprot.org/uniprot/R4NQ16 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/243274:THEMA_RS09590 ^@ http://purl.uniprot.org/uniprot/G4FF54|||http://purl.uniprot.org/uniprot/Q9X034 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.|||Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine. Adenosine-5-monophosphate (AMP) and S-adenosyl-L-methionine (SAM) are not enzyme substrates. http://togogenome.org/gene/243274:THEMA_RS02650 ^@ http://purl.uniprot.org/uniprot/Q9WYP3|||http://purl.uniprot.org/uniprot/R4NY41 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the zinc-containing alcohol dehydrogenase family.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the NAD(+)-dependent oxidation of scyllo-inosose (2-keto-myo-inositol) to 3-dehydro-scyllo-inosose (diketo-inositol), and thus probably functions in a myo-inositol degradation pathway together with IolG, IolN and IolO. Has no activity on myo-inositol, D-chiro-inositol and 1-keto-D-chiro-inositol.|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS04465 ^@ http://purl.uniprot.org/uniprot/Q9WXR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS08085 ^@ http://purl.uniprot.org/uniprot/Q9X0W0|||http://purl.uniprot.org/uniprot/R4P0G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS00330 ^@ http://purl.uniprot.org/uniprot/Q9WZW5|||http://purl.uniprot.org/uniprot/R4P1M7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecF subfamily.|||Cell inner membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/243274:THEMA_RS01130 ^@ http://purl.uniprot.org/uniprot/G4FDB7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of a guanine in 16S rRNA. http://togogenome.org/gene/243274:THEMA_RS02300 ^@ http://purl.uniprot.org/uniprot/G4FDZ2|||http://purl.uniprot.org/uniprot/Q9WYU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS05955 ^@ http://purl.uniprot.org/uniprot/G4FG33|||http://purl.uniprot.org/uniprot/Q9X1X7 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the quinolinate synthase family. Type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Cytoplasm|||Inhibited by 4,5 dithiohydroxyphthalic acid (DTHPA) analogs, which bind to the catalytic iron site of the [4Fe-4S] cluster. http://togogenome.org/gene/243274:THEMA_RS01365 ^@ http://purl.uniprot.org/uniprot/Q9WZC8|||http://purl.uniprot.org/uniprot/R4NPC0 ^@ Similarity ^@ Belongs to the SAM hydrolase / SAM-dependent halogenase family. http://togogenome.org/gene/243274:THEMA_RS06380 ^@ http://purl.uniprot.org/uniprot/Q9X1Q1|||http://purl.uniprot.org/uniprot/R4P1H6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/243274:THEMA_RS01910 ^@ http://purl.uniprot.org/uniprot/G4FDR8|||http://purl.uniprot.org/uniprot/Q9WZ23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.|||Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS06515 ^@ http://purl.uniprot.org/uniprot/G4FFS7|||http://purl.uniprot.org/uniprot/Q9X1M5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.|||Bacterial flagellum basal body|||Belongs to the FlgI family.|||Periplasm|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. http://togogenome.org/gene/243274:THEMA_RS08010 ^@ http://purl.uniprot.org/uniprot/G4FE99|||http://purl.uniprot.org/uniprot/Q9X0X6 ^@ Domain|||Similarity ^@ Belongs to the PurH family.|||The IMP cyclohydrolase activity resides in the N-terminal region. http://togogenome.org/gene/243274:THEMA_RS02630 ^@ http://purl.uniprot.org/uniprot/Q9WYP7 ^@ Activity Regulation|||Biotechnology|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the hyi family.|||Binds 1 divalent metal cation per subunit. Mn(2+) is the most efficient metal cofactor, but can also use other divalent metal cations such as Ni(2+), Mg(2+), and, to a lesser extent, Co(2+) and Zn(2+), but not Ca(2+), Cu(2+), and Fe(2+).|||Catalyzes the reversible epimerization between 5-keto-L-gluconate (5-dehydro-L-gluconate) and D-tagaturonate, and thus probably functions in a myo-inositol degradation pathway together with IolG, IolM and IolN (PubMed:23441918). Is not active on the enantiomer 5-keto-D-gluconate (PubMed:23441918). Was also shown to be a nonphosphorylated sugar isomerase with broad substrate specificity in vitro (PubMed:28258150). Is able to catalyze the reversible C3-epimerization of L-ribulose to L-xylulose, D-ribulose to D-xylulose, D-psicose to D-fructose, and D-tagatose to D-sorbose, with a substrate preference for ketopentoses rather than ketohexoses (PubMed:28258150). Also catalyzes the aldose-ketose isomerization reaction from either D-erythrose or D-threose to D-erythrulose (PubMed:28258150). Exhibits no activity for C4-epimerization of D-tagatose to D-fructose (PubMed:28258150).|||High thermostability and very broad substrate specificity of this enzyme make it a potential candidate for the production of rare sugars for the food and pharmaceutical industries.|||Homodimer.|||Is completely inhibited by EDTA in vitro. http://togogenome.org/gene/243274:THEMA_RS04600 ^@ http://purl.uniprot.org/uniprot/Q9WXN9|||http://purl.uniprot.org/uniprot/R4NMJ0 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/243274:THEMA_RS02560 ^@ http://purl.uniprot.org/uniprot/Q9WYR1|||http://purl.uniprot.org/uniprot/R4NYF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS02245 ^@ http://purl.uniprot.org/uniprot/Q9WYV6|||http://purl.uniprot.org/uniprot/R4P0K3 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/243274:THEMA_RS06940 ^@ http://purl.uniprot.org/uniprot/G4FFJ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/243274:THEMA_RS01765 ^@ http://purl.uniprot.org/uniprot/G4FDP0|||http://purl.uniprot.org/uniprot/Q9WZ49 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.|||Belongs to the AAA ATPase family.|||Binds 1 zinc ion per subunit.|||Cell inner membrane|||Homohexamer.|||In the C-terminal section; belongs to the peptidase M41 family.|||In the central section; belongs to the AAA ATPase family.|||The isolated ADP-bound cytosolic domain forms a 6-fold symmetric protease disk and a 2-fold symmetric AAA ATPase ring. In the absence of nucleotide the AAA ATPase ring also forms symmetric hexamers. http://togogenome.org/gene/243274:THEMA_RS03540 ^@ http://purl.uniprot.org/uniprot/Q9WY75|||http://purl.uniprot.org/uniprot/R4NY16 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS06015 ^@ http://purl.uniprot.org/uniprot/Q9X1W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsaE family.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS04035 ^@ http://purl.uniprot.org/uniprot/G4FH59|||http://purl.uniprot.org/uniprot/Q9WXZ2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Forms an hexamer composed of two TsaB, TsaD and TsaE trimers.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. http://togogenome.org/gene/243274:THEMA_RS04180 ^@ http://purl.uniprot.org/uniprot/Q9WXX1|||http://purl.uniprot.org/uniprot/R4NXA5 ^@ Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate. http://togogenome.org/gene/243274:THEMA_RS06105 ^@ http://purl.uniprot.org/uniprot/G4FG03|||http://purl.uniprot.org/uniprot/Q9X1V0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase C chain family.|||Cell inner membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/243274:THEMA_RS00780 ^@ http://purl.uniprot.org/uniprot/Q9WZN2|||http://purl.uniprot.org/uniprot/R4NPP6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL8 family. http://togogenome.org/gene/243274:THEMA_RS04895 ^@ http://purl.uniprot.org/uniprot/Q08638 ^@ Caution|||Similarity ^@ As the DNA coding for this protein is not found in the complete genome of T.maritima. It could have originated from another bacterial species.|||Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/243274:THEMA_RS07725 ^@ http://purl.uniprot.org/uniprot/Q9X132|||http://purl.uniprot.org/uniprot/R4P0X0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS06345 ^@ http://purl.uniprot.org/uniprot/Q9X1Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Membrane http://togogenome.org/gene/243274:THEMA_RS03915 ^@ http://purl.uniprot.org/uniprot/G4FH83|||http://purl.uniprot.org/uniprot/Q9WY16 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional regulatory Rex family.|||Cytoplasm|||Homodimer.|||Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. http://togogenome.org/gene/243274:THEMA_RS08210 ^@ http://purl.uniprot.org/uniprot/G4FED8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS04675 ^@ http://purl.uniprot.org/uniprot/O05651 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/243274:THEMA_RS04355 ^@ http://purl.uniprot.org/uniprot/G4FGZ6|||http://purl.uniprot.org/uniprot/Q9WXT6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.|||Belongs to the FliW family.|||Cytoplasm|||Interacts with translational regulator CsrA and flagellin(s). http://togogenome.org/gene/243274:THEMA_RS02405 ^@ http://purl.uniprot.org/uniprot/G4FE13|||http://purl.uniprot.org/uniprot/P29396 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the 50S ribosomal subunit; present in 6 copies per ribosome. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which 3 L12 dimers bind in a sequential fashion.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/243274:THEMA_RS05960 ^@ http://purl.uniprot.org/uniprot/G4FG32|||http://purl.uniprot.org/uniprot/Q9X1X6 ^@ Activity Regulation|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the L-aspartate dehydrogenase family.|||Competitively inhibited by L-malate and NH(4)(+).|||Homodimer.|||Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.|||Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. Does not show aspartate oxidase activity. Is also able to catalyze the reverse reaction, i.e. the reductive amination of oxaloacetate.|||The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia. http://togogenome.org/gene/243274:THEMA_RS06505 ^@ http://purl.uniprot.org/uniprot/Q9X1M7|||http://purl.uniprot.org/uniprot/R4P3G4 ^@ Subcellular Location Annotation ^@ Periplasm http://togogenome.org/gene/243274:THEMA_RS08285 ^@ http://purl.uniprot.org/uniprot/G4FEF3|||http://purl.uniprot.org/uniprot/Q56307 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 2 family. http://togogenome.org/gene/243274:THEMA_RS02820 ^@ http://purl.uniprot.org/uniprot/Q9WYK9|||http://purl.uniprot.org/uniprot/R4NY10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS09115 ^@ http://purl.uniprot.org/uniprot/Q9X0C1|||http://purl.uniprot.org/uniprot/R4NZT9 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/243274:THEMA_RS01050 ^@ http://purl.uniprot.org/uniprot/G4FDA1|||http://purl.uniprot.org/uniprot/Q9WZI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.|||Belongs to the RNR ribonuclease family. RNase R subfamily.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS04840 ^@ http://purl.uniprot.org/uniprot/Q9X2H3|||http://purl.uniprot.org/uniprot/R4P2E9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecX family.|||Cytoplasm|||Modulates RecA activity. http://togogenome.org/gene/243274:THEMA_RS02870 ^@ http://purl.uniprot.org/uniprot/G4FHS8|||http://purl.uniprot.org/uniprot/Q9WYK0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/243274:THEMA_RS02815 ^@ http://purl.uniprot.org/uniprot/G4FHT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS01375 ^@ http://purl.uniprot.org/uniprot/G4FDG6|||http://purl.uniprot.org/uniprot/Q9WZC6 ^@ Function|||Similarity ^@ Belongs to the desulfoferrodoxin family.|||Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide. http://togogenome.org/gene/243274:THEMA_RS06055 ^@ http://purl.uniprot.org/uniprot/Q9X1V9|||http://purl.uniprot.org/uniprot/R4P1P3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 2 family. http://togogenome.org/gene/243274:THEMA_RS06840 ^@ http://purl.uniprot.org/uniprot/G4FFL3|||http://purl.uniprot.org/uniprot/Q9X1I6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/243274:THEMA_RS09070 ^@ http://purl.uniprot.org/uniprot/G4FEV8|||http://purl.uniprot.org/uniprot/Q9X0D0 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS07010 ^@ http://purl.uniprot.org/uniprot/G4FFH9|||http://purl.uniprot.org/uniprot/Q9X1F7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspH family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. http://togogenome.org/gene/243274:THEMA_RS02830 ^@ http://purl.uniprot.org/uniprot/Q9WYK7|||http://purl.uniprot.org/uniprot/R4NYB8 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/243274:THEMA_RS01770 ^@ http://purl.uniprot.org/uniprot/Q9WZ48|||http://purl.uniprot.org/uniprot/R4NYV0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA(Ile)-lysidine synthase family.|||Cytoplasm|||Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.|||The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding. http://togogenome.org/gene/243274:THEMA_RS05680 ^@ http://purl.uniprot.org/uniprot/Q9X224 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/243274:THEMA_RS09170 ^@ http://purl.uniprot.org/uniprot/G4FEX7|||http://purl.uniprot.org/uniprot/R4P012 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS07320 ^@ http://purl.uniprot.org/uniprot/G4FFC1|||http://purl.uniprot.org/uniprot/Q9X1A5 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPI family.|||Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.|||Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate. Does not have phosphomannose isomerase (PMI) activity. Isomerization proceeds through a cis-enediol-based mechanism.|||Cytoplasm|||Homodimer.|||Optimal activity is achieved when His-310 and Lys-422 are both present to open the sugar ring, and Glu-281 catalyzes the isomerization step (PubMed:33422670). Activity is decreased in the presence of the PGI inhibitor 6-phosphogluconate (PubMed:33422670). http://togogenome.org/gene/243274:THEMA_RS03195 ^@ http://purl.uniprot.org/uniprot/Q9WYD8|||http://purl.uniprot.org/uniprot/R4NPV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS00640 ^@ http://purl.uniprot.org/uniprot/Q9WZQ9|||http://purl.uniprot.org/uniprot/R4P1H7 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/243274:THEMA_RS07620 ^@ http://purl.uniprot.org/uniprot/Q9X151|||http://purl.uniprot.org/uniprot/R4P0N6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS07015 ^@ http://purl.uniprot.org/uniprot/G4FFH8|||http://purl.uniprot.org/uniprot/Q9X1F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS07700 ^@ http://purl.uniprot.org/uniprot/Q9X138|||http://purl.uniprot.org/uniprot/R4P0X4 ^@ Similarity ^@ Belongs to the HicA mRNA interferase family. http://togogenome.org/gene/243274:THEMA_RS04965 ^@ http://purl.uniprot.org/uniprot/G4FGM5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/243274:THEMA_RS00180 ^@ http://purl.uniprot.org/uniprot/G4FCT4|||http://purl.uniprot.org/uniprot/Q9WZZ3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspG family.|||Binds 1 [4Fe-4S] cluster.|||Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. http://togogenome.org/gene/243274:THEMA_RS03965 ^@ http://purl.uniprot.org/uniprot/G4FH73|||http://purl.uniprot.org/uniprot/Q9WY06 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/243274:THEMA_RS03625 ^@ http://purl.uniprot.org/uniprot/G4FHD0|||http://purl.uniprot.org/uniprot/Q9WY59 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/243274:THEMA_RS08930 ^@ http://purl.uniprot.org/uniprot/Q9S5X4|||http://purl.uniprot.org/uniprot/R4NRY3 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 4 family.|||Binds 1 NAD(+) per subunit. http://togogenome.org/gene/243274:THEMA_RS08185 ^@ http://purl.uniprot.org/uniprot/Q9X0U0|||http://purl.uniprot.org/uniprot/R4P0B9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS00915 ^@ http://purl.uniprot.org/uniprot/G4FD75 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.|||Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.|||Homotetramer composed of a dimer of dimers. http://togogenome.org/gene/243274:THEMA_RS00715 ^@ http://purl.uniprot.org/uniprot/G4FD37 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the THI4 family.|||Homooctamer; tetramer of dimers.|||Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS01340 ^@ http://purl.uniprot.org/uniprot/Q9WZD3|||http://purl.uniprot.org/uniprot/R4NPC5 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/243274:THEMA_RS02965 ^@ http://purl.uniprot.org/uniprot/G4FHQ9|||http://purl.uniprot.org/uniprot/Q9WYI2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/243274:THEMA_RS08300 ^@ http://purl.uniprot.org/uniprot/G4FEF6|||http://purl.uniprot.org/uniprot/P56838 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. GalK subfamily.|||Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS04015 ^@ http://purl.uniprot.org/uniprot/G4FH63|||http://purl.uniprot.org/uniprot/Q9WXZ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsX family.|||Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.|||Cytoplasm|||Homodimer. Probably interacts with PlsY. http://togogenome.org/gene/243274:THEMA_RS03455 ^@ http://purl.uniprot.org/uniprot/Q9WY92|||http://purl.uniprot.org/uniprot/R4NXR6 ^@ Similarity ^@ Belongs to the DprA/Smf family. http://togogenome.org/gene/243274:THEMA_RS01640 ^@ http://purl.uniprot.org/uniprot/G4FDL5|||http://purl.uniprot.org/uniprot/Q9WZ73 ^@ Caution|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS04320 ^@ http://purl.uniprot.org/uniprot/G4FH03 ^@ Similarity ^@ Belongs to the bacterial secretin family. http://togogenome.org/gene/243274:THEMA_RS03525 ^@ http://purl.uniprot.org/uniprot/Q9WY78|||http://purl.uniprot.org/uniprot/R4NN74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurF subfamily.|||Cytoplasm|||Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. http://togogenome.org/gene/243274:THEMA_RS03015 ^@ http://purl.uniprot.org/uniprot/G4FHQ0|||http://purl.uniprot.org/uniprot/Q9WYH2 ^@ Cofactor|||Similarity ^@ Belongs to the UPF0313 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/243274:THEMA_RS01155 ^@ http://purl.uniprot.org/uniprot/Q56310 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY (By similarity). http://togogenome.org/gene/243274:THEMA_RS04610 ^@ http://purl.uniprot.org/uniprot/Q9WXN7|||http://purl.uniprot.org/uniprot/R4NZC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS09575 ^@ http://purl.uniprot.org/uniprot/G4FF51|||http://purl.uniprot.org/uniprot/Q9X037 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanD family.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.|||Cytoplasm|||Heterooctamer of four alpha and four beta subunits.|||Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus. http://togogenome.org/gene/243274:THEMA_RS06610 ^@ http://purl.uniprot.org/uniprot/Q9X1L0|||http://purl.uniprot.org/uniprot/R4P159 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the diaminopimelate epimerase family.|||Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (PubMed:30548096). Also catalyzes the racemization of certain amino acids, including Lys, with low efficiency (PubMed:30548096).|||Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Probably forms homotrimers. http://togogenome.org/gene/243274:THEMA_RS08760 ^@ http://purl.uniprot.org/uniprot/G4FEP7 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/243274:THEMA_RS06850 ^@ http://purl.uniprot.org/uniprot/G4FFL1|||http://purl.uniprot.org/uniprot/Q9X1I4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/243274:THEMA_RS09730 ^@ http://purl.uniprot.org/uniprot/Q9X1N1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YqgF nuclease family.|||Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS06860 ^@ http://purl.uniprot.org/uniprot/G4FFK9|||http://purl.uniprot.org/uniprot/Q9X1I2 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/243274:THEMA_RS01300 ^@ http://purl.uniprot.org/uniprot/Q9WZE1|||http://purl.uniprot.org/uniprot/R4P151 ^@ Function|||Similarity ^@ Belongs to the FlgD family.|||Required for flagellar hook formation. May act as a scaffolding protein. http://togogenome.org/gene/243274:THEMA_RS01220 ^@ http://purl.uniprot.org/uniprot/G4FDD5|||http://purl.uniprot.org/uniprot/P36204 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||In the C-terminal section; belongs to the triosephosphate isomerase family.|||In the N-terminal section; belongs to the phosphoglycerate kinase family.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).|||Monomer (PGK) and homotetramer (PGK-TIM).|||Monomer. http://togogenome.org/gene/243274:THEMA_RS07640 ^@ http://purl.uniprot.org/uniprot/Q9X147|||http://purl.uniprot.org/uniprot/R4P0N2 ^@ Similarity ^@ Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. http://togogenome.org/gene/243274:THEMA_RS00415 ^@ http://purl.uniprot.org/uniprot/Q9WZU9|||http://purl.uniprot.org/uniprot/R4NZL9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS06885 ^@ http://purl.uniprot.org/uniprot/P58010 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/243274:THEMA_RS03605 ^@ http://purl.uniprot.org/uniprot/G4FHD4|||http://purl.uniprot.org/uniprot/Q9WY63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the FliG family.|||Cell inner membrane|||Homodimer in the absence of FliF. Interacts (via N-terminus) with FliF (via C-terminus) forming a heterodimer. Interacts (via central domain or via central domain and C-terminus) with FliM (via central domain).|||Membrane|||One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).|||One of the proteins that forms a switch complex that is proposed to be located at the base of the basal body. This complex interacts with chemotaxis proteins (such as CheY) in addition to contacting components of the motor that determine the direction of flagellar rotation. http://togogenome.org/gene/243274:THEMA_RS08550 ^@ http://purl.uniprot.org/uniprot/Q9X0M7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family.|||Cell membrane|||Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. http://togogenome.org/gene/243274:THEMA_RS01800 ^@ http://purl.uniprot.org/uniprot/G4FDP6|||http://purl.uniprot.org/uniprot/Q9WZ44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueA family.|||Cytoplasm|||Monomer.|||Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). http://togogenome.org/gene/243274:THEMA_RS06855 ^@ http://purl.uniprot.org/uniprot/G4FFL0|||http://purl.uniprot.org/uniprot/Q9X1I3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||Binds 1 zinc ion per subunit.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity (By similarity).|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/243274:THEMA_RS09055 ^@ http://purl.uniprot.org/uniprot/Q9X0D3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.|||Cytoplasm|||Heteromultimer composed of HisG and HisZ subunits.|||Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity).|||This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one. http://togogenome.org/gene/243274:THEMA_RS00095 ^@ http://purl.uniprot.org/uniprot/Q9X010|||http://purl.uniprot.org/uniprot/R4NQ08 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin. http://togogenome.org/gene/243274:THEMA_RS01680 ^@ http://purl.uniprot.org/uniprot/Q9WZ65|||http://purl.uniprot.org/uniprot/R4NP46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS05510 ^@ http://purl.uniprot.org/uniprot/Q9X254|||http://purl.uniprot.org/uniprot/R4P1U3 ^@ Similarity ^@ Belongs to the YggT family. http://togogenome.org/gene/243274:THEMA_RS03045 ^@ http://purl.uniprot.org/uniprot/G4FHP4|||http://purl.uniprot.org/uniprot/Q9WYG6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS03265 ^@ http://purl.uniprot.org/uniprot/G4FHK2|||http://purl.uniprot.org/uniprot/Q9WYC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS07020 ^@ http://purl.uniprot.org/uniprot/G4FFH7|||http://purl.uniprot.org/uniprot/Q9X1F5 ^@ Function|||PTM|||Similarity ^@ Belongs to the anti-sigma-factor antagonist family.|||In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts an anti-sigma factor and thus releases a sigma factor from inhibition.|||Phosphorylated on a serine residue. http://togogenome.org/gene/243274:THEMA_RS07405 ^@ http://purl.uniprot.org/uniprot/Q9X189|||http://purl.uniprot.org/uniprot/R4NR72 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/243274:THEMA_RS04990 ^@ http://purl.uniprot.org/uniprot/O33830|||http://purl.uniprot.org/uniprot/R4P2C3 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Alpha-glycosidase with a very broad specificity. Hydrolyzes maltose and other small maltooligosaccharides but is inactive against the polymeric substrate starch. AglA is not specific with respect to the configuration at the C-4 position of its substrates because glycosidic derivatives of D-galactose are also hydrolyzed. Does not cleave beta-glycosidic bonds.|||Belongs to the glycosyl hydrolase 4 family.|||Binds 1 Mn(2+) ion per subunit. Can also use Co(2+) and Ni(2+) ions, albeit less efficiently than manganese ion.|||Binds 1 NAD(+) per subunit.|||Homodimer.|||In the crystal structure (PubMed:12588867), the metal ion is absent, probably due to the oxidation of the active site Cys-174 to sulfinic acid. In the absence of metal, positions of the coenzyme and the substrate and their interactions are all significantly altered, presumably accounting for the inactivity of this form.|||Inhibited by Hg(2+) ion and EDTA. http://togogenome.org/gene/243274:THEMA_RS04615 ^@ http://purl.uniprot.org/uniprot/Q9WXN6|||http://purl.uniprot.org/uniprot/R4NXC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS04635 ^@ http://purl.uniprot.org/uniprot/Q9WXN2|||http://purl.uniprot.org/uniprot/R4NZC1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/243274:THEMA_RS03675 ^@ http://purl.uniprot.org/uniprot/G4FHC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS05700 ^@ http://purl.uniprot.org/uniprot/G4FG81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS02940 ^@ http://purl.uniprot.org/uniprot/Q9WYI7 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/243274:THEMA_RS03600 ^@ http://purl.uniprot.org/uniprot/Q9WY64|||http://purl.uniprot.org/uniprot/R4NN39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliF family.|||Membrane|||The M ring may be actively involved in energy transduction. http://togogenome.org/gene/243274:THEMA_RS05235 ^@ http://purl.uniprot.org/uniprot/G4FGH2|||http://purl.uniprot.org/uniprot/Q9X2A5 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/243274:THEMA_RS05480 ^@ http://purl.uniprot.org/uniprot/Q9X260|||http://purl.uniprot.org/uniprot/R4NSB7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS01180 ^@ http://purl.uniprot.org/uniprot/Q9WZG1|||http://purl.uniprot.org/uniprot/R4NZ68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliQ/MopD/SpaQ family.|||Cell membrane|||Membrane|||Role in flagellar biosynthesis. http://togogenome.org/gene/243274:THEMA_RS09270 ^@ http://purl.uniprot.org/uniprot/Q9X095 ^@ Similarity ^@ Belongs to the UPF0332 family. http://togogenome.org/gene/243274:THEMA_RS05860 ^@ http://purl.uniprot.org/uniprot/Q9X1Z1 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (Probable). Expression of the complex plus RibU in E.coli allows riboflavin uptake; uptake does not occur in the absence of RibU or the EcfA1A2T complex.|||Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.|||Cell inner membrane|||Forms a heterodimer with EcfA2. Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component, RibU, BioY), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component) upon coexpression in E.coli. Stable subcomplexes with both A plus T components can also be isolated. This complex interacts with at least 2 substrate-specific components, BioY and RibU.|||Structure 4HLU is probably in the open state. http://togogenome.org/gene/243274:THEMA_RS05280 ^@ http://purl.uniprot.org/uniprot/Q9X297|||http://purl.uniprot.org/uniprot/R4NSE6 ^@ Cofactor|||Similarity ^@ Belongs to the Fur family.|||Binds 1 Mn(2+) or Fe(2+) ion per subunit.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/243274:THEMA_RS05865 ^@ http://purl.uniprot.org/uniprot/G4FG51|||http://purl.uniprot.org/uniprot/P96112 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SurE nucleotidase family.|||Binds 1 Mg(2+) ion per subunit. In contrast to other surE homologs, is essentially inactive with other divalent cations.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Homodimer and possibly homotetramer.|||Inhibited by vanadate and tungstate.|||Nucleotidase that preferentially dephosphorylates 5'-GMP and 5'-AMP.|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.|||Was originally annotated as an acid phosphatase (EC 3.1.3.2). http://togogenome.org/gene/243274:THEMA_RS03285 ^@ http://purl.uniprot.org/uniprot/Q9WYC0|||http://purl.uniprot.org/uniprot/R4P026 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/243274:THEMA_RS02905 ^@ http://purl.uniprot.org/uniprot/Q9WYJ4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MDIP synthase family.|||Catalyzes the transfer of the mannosyl group from GDP-mannose to di-myo-inositol-1,3'-phosphate (DIP), producing mannosyl-di-myo-inositol phosphate (MDIP). Can also use MDIP as an acceptor of a second mannose residue, yielding di-mannosyl-di-myo-inositol phosphate (MMDIP). Minor amounts of the tri-mannosylated form are also formed.|||Mg(2+) is required for maximal activity. http://togogenome.org/gene/243274:THEMA_RS06815 ^@ http://purl.uniprot.org/uniprot/G4FFL8|||http://purl.uniprot.org/uniprot/Q9X1J0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/243274:THEMA_RS01980 ^@ http://purl.uniprot.org/uniprot/G4FDT2|||http://purl.uniprot.org/uniprot/Q9WZ09 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/243274:THEMA_RS03445 ^@ http://purl.uniprot.org/uniprot/G4FHG6|||http://purl.uniprot.org/uniprot/Q9WY94 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity).|||Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/243274:THEMA_RS00335 ^@ http://purl.uniprot.org/uniprot/Q9WZW4|||http://purl.uniprot.org/uniprot/R4NZM8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell inner membrane|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/243274:THEMA_RS04545 ^@ http://purl.uniprot.org/uniprot/G4FGW0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS03175 ^@ http://purl.uniprot.org/uniprot/G4FHM0 ^@ Function ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. http://togogenome.org/gene/243274:THEMA_RS03295 ^@ http://purl.uniprot.org/uniprot/Q9WYB8|||http://purl.uniprot.org/uniprot/R4NPT5 ^@ Similarity ^@ Belongs to the aldose epimerase family. http://togogenome.org/gene/243274:THEMA_RS02975 ^@ http://purl.uniprot.org/uniprot/G4FHQ7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/243274:THEMA_RS03925 ^@ http://purl.uniprot.org/uniprot/G4FH81|||http://purl.uniprot.org/uniprot/Q9WY14 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphopentomutase family.|||Binds 1 or 2 manganese ions.|||Cytoplasm|||Phosphotransfer between the C1 and C5 carbon atoms of pentose. http://togogenome.org/gene/243274:THEMA_RS06385 ^@ http://purl.uniprot.org/uniprot/G4FFV2|||http://purl.uniprot.org/uniprot/Q9X1Q0 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/243274:THEMA_RS00460 ^@ http://purl.uniprot.org/uniprot/G4FCY8|||http://purl.uniprot.org/uniprot/O08398 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins (By similarity). Interacts with FtsA (PubMed:22473211).|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/243274:THEMA_RS01355 ^@ http://purl.uniprot.org/uniprot/G4FDG2|||http://purl.uniprot.org/uniprot/Q9WZD0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS02215 ^@ http://purl.uniprot.org/uniprot/G4FDX8|||http://purl.uniprot.org/uniprot/Q9WYW2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS08360 ^@ http://purl.uniprot.org/uniprot/Q9X0R1|||http://purl.uniprot.org/uniprot/R4NQQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FliS family.|||cytosol http://togogenome.org/gene/243274:THEMA_RS03710 ^@ http://purl.uniprot.org/uniprot/Q9WY42|||http://purl.uniprot.org/uniprot/R4NZU6 ^@ Domain|||Function|||Similarity ^@ Belongs to the RecA family. RadA subfamily.|||DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.|||Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.|||The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. http://togogenome.org/gene/243274:THEMA_RS01450 ^@ http://purl.uniprot.org/uniprot/Q9WZB1|||http://purl.uniprot.org/uniprot/R4P121 ^@ Similarity ^@ Belongs to the intimin/invasin family. http://togogenome.org/gene/243274:THEMA_RS09095 ^@ http://purl.uniprot.org/uniprot/G4FEW3 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the PRA-PH family.|||In the N-terminal section; belongs to the PRA-CH family. http://togogenome.org/gene/243274:THEMA_RS02690 ^@ http://purl.uniprot.org/uniprot/G4FHW3 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/243274:THEMA_RS00090 ^@ http://purl.uniprot.org/uniprot/Q9X011 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type III secretion exporter family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin. http://togogenome.org/gene/243274:THEMA_RS00070 ^@ http://purl.uniprot.org/uniprot/Q9X015 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Belongs to the nucleoside triphosphate pyrophosphohydrolase family.|||Catalyzes the hydrolysis of all eight canonical ribonucleoside triphosphates (NTP) and deoxyribonucleoside triphosphates (dNTP) to their corresponding nucleoside monophosphates ((d)NMP) and PPi and subsequently hydrolyzes the resultant PPi to Pi. The NTPase activity with deoxyribonucleoside triphosphates as substrate is higher than corresponding ribonucleoside triphosphates. dGTP is the best substrate among the deoxyribonucleoside triphosphates, and GTP is the best among the ribonucleoside triphosphates.|||Homodimer.|||Inhibited by AMPCPP (alpha,beta-methyleneadenosine triphosphate). http://togogenome.org/gene/243274:THEMA_RS04400 ^@ http://purl.uniprot.org/uniprot/Q9WXS7|||http://purl.uniprot.org/uniprot/R4NMM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS04185 ^@ http://purl.uniprot.org/uniprot/Q9WXX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.|||Cell inner membrane|||Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system.|||The complex is composed of an ATP-binding protein (RbsA), two transmembrane proteins (RbsC) and a solute-binding protein (RbsB). http://togogenome.org/gene/243274:THEMA_RS09285 ^@ http://purl.uniprot.org/uniprot/G4FEZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS01815 ^@ http://purl.uniprot.org/uniprot/Q9WZ41|||http://purl.uniprot.org/uniprot/R4NYI7 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/243274:THEMA_RS00770 ^@ http://purl.uniprot.org/uniprot/Q9WZN4|||http://purl.uniprot.org/uniprot/R4NZG6 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/243274:THEMA_RS03030 ^@ http://purl.uniprot.org/uniprot/Q9WYG9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrK family.|||Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit.|||Heterotetramer of 2 PyrK and 2 PyrD type B subunits.|||Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). http://togogenome.org/gene/243274:THEMA_RS01285 ^@ http://purl.uniprot.org/uniprot/Q9WZE3|||http://purl.uniprot.org/uniprot/R4NQW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MotA family.|||Membrane http://togogenome.org/gene/243274:THEMA_RS05160 ^@ http://purl.uniprot.org/uniprot/Q9X2B8|||http://purl.uniprot.org/uniprot/R4P295 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/243274:THEMA_RS08865 ^@ http://purl.uniprot.org/uniprot/G4FER7|||http://purl.uniprot.org/uniprot/Q9X0H0 ^@ Function|||PTM|||Similarity ^@ Belongs to the anti-sigma-factor antagonist family.|||In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts an anti-sigma factor and thus releases a sigma factor from inhibition.|||Phosphorylated on a serine residue. http://togogenome.org/gene/243274:THEMA_RS04235 ^@ http://purl.uniprot.org/uniprot/Q9WXW0|||http://purl.uniprot.org/uniprot/R4NZK2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS03485 ^@ http://purl.uniprot.org/uniprot/G4FHF8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.|||Binds 2 [4Fe-4S] clusters per subunit.|||Cell inner membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/243274:THEMA_RS05095 ^@ http://purl.uniprot.org/uniprot/Q9X2D1|||http://purl.uniprot.org/uniprot/R4NU38 ^@ Similarity ^@ Belongs to the CRISPR-associated Cas10/Csm1 family. http://togogenome.org/gene/243274:THEMA_RS07525 ^@ http://purl.uniprot.org/uniprot/Q9X167|||http://purl.uniprot.org/uniprot/R4P100 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/243274:THEMA_RS05435 ^@ http://purl.uniprot.org/uniprot/G4FGD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS06870 ^@ http://purl.uniprot.org/uniprot/G4FFK7|||http://purl.uniprot.org/uniprot/P38527 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the Rho family.|||Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.|||Homohexamer. The homohexamer assembles into an open ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS07580 ^@ http://purl.uniprot.org/uniprot/Q9X158|||http://purl.uniprot.org/uniprot/R4P2Y7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS00025 ^@ http://purl.uniprot.org/uniprot/R4NZJ5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family. http://togogenome.org/gene/243274:THEMA_RS04570 ^@ http://purl.uniprot.org/uniprot/Q9WXP5|||http://purl.uniprot.org/uniprot/R4NP53 ^@ Cofactor|||Similarity ^@ Belongs to the PTPS family. QueD subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/243274:THEMA_RS05070 ^@ http://purl.uniprot.org/uniprot/G4FGK4|||http://purl.uniprot.org/uniprot/Q9X2D7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/243274:THEMA_RS06095 ^@ http://purl.uniprot.org/uniprot/Q9X1V2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS07445 ^@ http://purl.uniprot.org/uniprot/Q9X182|||http://purl.uniprot.org/uniprot/R4P303 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/243274:THEMA_RS09355 ^@ http://purl.uniprot.org/uniprot/G4FF12|||http://purl.uniprot.org/uniprot/Q9X078 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/243274:THEMA_RS00305 ^@ http://purl.uniprot.org/uniprot/Q9WZX0|||http://purl.uniprot.org/uniprot/R4P1N2 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/243274:THEMA_RS04910 ^@ http://purl.uniprot.org/uniprot/G4FGN6|||http://purl.uniprot.org/uniprot/R4P4D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS03270 ^@ http://purl.uniprot.org/uniprot/Q9WYC3|||http://purl.uniprot.org/uniprot/R4NPT9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS06550 ^@ http://purl.uniprot.org/uniprot/Q9X1L8|||http://purl.uniprot.org/uniprot/R4P168 ^@ Similarity ^@ Belongs to the ETF-QO/FixC family. http://togogenome.org/gene/243274:THEMA_RS08240 ^@ http://purl.uniprot.org/uniprot/Q9X0S9|||http://purl.uniprot.org/uniprot/R4P2L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS03400 ^@ http://purl.uniprot.org/uniprot/Q9WY99|||http://purl.uniprot.org/uniprot/R4NN92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane http://togogenome.org/gene/243274:THEMA_RS02885 ^@ http://purl.uniprot.org/uniprot/Q9WYJ8|||http://purl.uniprot.org/uniprot/R4NQ07 ^@ Function|||Similarity|||Subunit ^@ Associates with stalled 50S ribosomal subunits.|||Belongs to the NEMF family.|||Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits. http://togogenome.org/gene/243274:THEMA_RS03230 ^@ http://purl.uniprot.org/uniprot/G4FHK9|||http://purl.uniprot.org/uniprot/Q9WYD1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transaldolase family. Type 3B subfamily.|||Cytoplasm|||Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.|||Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Does not show fructose-6-P aldolase activity. http://togogenome.org/gene/243274:THEMA_RS06920 ^@ http://purl.uniprot.org/uniprot/G4FFJ7|||http://purl.uniprot.org/uniprot/Q9X1H3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell inner membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/243274:THEMA_RS08735 ^@ http://purl.uniprot.org/uniprot/Q9X0J0|||http://purl.uniprot.org/uniprot/R4NS22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS00660 ^@ http://purl.uniprot.org/uniprot/Q9WZQ5|||http://purl.uniprot.org/uniprot/R4NZ90 ^@ Similarity ^@ Belongs to the fabD family. http://togogenome.org/gene/243274:THEMA_RS09020 ^@ http://purl.uniprot.org/uniprot/Q9X0E0|||http://purl.uniprot.org/uniprot/R4P256 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/243274:THEMA_RS07895 ^@ http://purl.uniprot.org/uniprot/G4FE76 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/243274:THEMA_RS05330 ^@ http://purl.uniprot.org/uniprot/Q9X287|||http://purl.uniprot.org/uniprot/R4P1X2 ^@ Similarity ^@ Belongs to the formate--tetrahydrofolate ligase family. http://togogenome.org/gene/243274:THEMA_RS00410 ^@ http://purl.uniprot.org/uniprot/Q9WZV0 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/243274:THEMA_RS04905 ^@ http://purl.uniprot.org/uniprot/G4FGN7|||http://purl.uniprot.org/uniprot/G4XU72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS06035 ^@ http://purl.uniprot.org/uniprot/G4FG17|||http://purl.uniprot.org/uniprot/Q9X1W3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/243274:THEMA_RS01205 ^@ http://purl.uniprot.org/uniprot/G4FDD2|||http://purl.uniprot.org/uniprot/Q9WZF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/243274:THEMA_RS00065 ^@ http://purl.uniprot.org/uniprot/G4FCR2|||http://purl.uniprot.org/uniprot/Q9X016 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/243274:THEMA_RS01175 ^@ http://purl.uniprot.org/uniprot/Q9WZG2|||http://purl.uniprot.org/uniprot/R4P178 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliP/MopC/SpaP family.|||Cell membrane|||Membrane|||Plays a role in the flagellum-specific transport system. http://togogenome.org/gene/243274:THEMA_RS03465 ^@ http://purl.uniprot.org/uniprot/Q9WY90|||http://purl.uniprot.org/uniprot/R4NY28 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/243274:THEMA_RS04770 ^@ http://purl.uniprot.org/uniprot/Q9X2I5|||http://purl.uniprot.org/uniprot/R4NU99 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/243274:THEMA_RS05100 ^@ http://purl.uniprot.org/uniprot/Q9X2D0|||http://purl.uniprot.org/uniprot/R4NSG9 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated Csm2 family.|||This subunit may be involved in monitoring complementarity of crRNA and target RNA. http://togogenome.org/gene/243274:THEMA_RS00565 ^@ http://purl.uniprot.org/uniprot/Q9WZS4|||http://purl.uniprot.org/uniprot/R4P1I9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS03300 ^@ http://purl.uniprot.org/uniprot/Q9WYB7|||http://purl.uniprot.org/uniprot/R4NNA3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 51 family. http://togogenome.org/gene/243274:THEMA_RS05390 ^@ http://purl.uniprot.org/uniprot/G4FGE2|||http://purl.uniprot.org/uniprot/Q9X278 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetokinase family.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS09025 ^@ http://purl.uniprot.org/uniprot/Q9X0D9|||http://purl.uniprot.org/uniprot/R4P043 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/243274:THEMA_RS08960 ^@ http://purl.uniprot.org/uniprot/Q9X0F2|||http://purl.uniprot.org/uniprot/R4NQD9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 2 family. http://togogenome.org/gene/243274:THEMA_RS02595 ^@ http://purl.uniprot.org/uniprot/G4FHY2|||http://purl.uniprot.org/uniprot/Q9WYQ4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the iron-containing alcohol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). http://togogenome.org/gene/243274:THEMA_RS06060 ^@ http://purl.uniprot.org/uniprot/G4FG12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell inner membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/243274:THEMA_RS06570 ^@ http://purl.uniprot.org/uniprot/Q9X1L4|||http://purl.uniprot.org/uniprot/R4NRL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MenA family. Type 1 subfamily.|||Cell inner membrane|||Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).|||Membrane http://togogenome.org/gene/243274:THEMA_RS06845 ^@ http://purl.uniprot.org/uniprot/G4FFL2|||http://purl.uniprot.org/uniprot/Q9X1I5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/243274:THEMA_RS02225 ^@ http://purl.uniprot.org/uniprot/G4FDY0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sirtuin family. Class U subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. http://togogenome.org/gene/243274:THEMA_RS09900 ^@ http://purl.uniprot.org/uniprot/G4FDM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS03650 ^@ http://purl.uniprot.org/uniprot/G4FHC5|||http://purl.uniprot.org/uniprot/Q9WY54 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvT family.|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/243274:THEMA_RS05500 ^@ http://purl.uniprot.org/uniprot/G4FGC0|||http://purl.uniprot.org/uniprot/Q9X256 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/243274:THEMA_RS03340 ^@ http://purl.uniprot.org/uniprot/G4FHI7 ^@ Cofactor ^@ Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/243274:THEMA_RS09085 ^@ http://purl.uniprot.org/uniprot/G4FEW1|||http://purl.uniprot.org/uniprot/Q9X0C7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/243274:THEMA_RS08450 ^@ http://purl.uniprot.org/uniprot/Q9X0P4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Cell membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/243274:THEMA_RS02590 ^@ http://purl.uniprot.org/uniprot/G4FHY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69) family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS06410 ^@ http://purl.uniprot.org/uniprot/G4FFU7|||http://purl.uniprot.org/uniprot/Q9X1P5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.|||Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS02395 ^@ http://purl.uniprot.org/uniprot/P36252 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/243274:THEMA_RS06465 ^@ http://purl.uniprot.org/uniprot/Q9X1N4|||http://purl.uniprot.org/uniprot/R4NRN5 ^@ Similarity ^@ Belongs to the polysaccharide synthase family. http://togogenome.org/gene/243274:THEMA_RS06955 ^@ http://purl.uniprot.org/uniprot/Q9X1G6|||http://purl.uniprot.org/uniprot/R4NRF1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.|||Cell inner membrane|||Cell membrane|||Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component, RibU, BioY), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component) upon coexpression in E.coli. A stable subcomplex with both A and T components are also isolated. This complex interacts with at least 2 substrate-specific components, BioY and RibU.|||Membrane|||Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.|||Substrate-binding (S) component of an energy-coupling factor (ECF) ABC-transporter complex. Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins (Probable). Expression of the complex plus RibU in E.coli allows riboflavin uptake; uptake does not occur in the absence of RibU or the EcfA1A2T complex. http://togogenome.org/gene/243274:THEMA_RS06475 ^@ http://purl.uniprot.org/uniprot/Q9X1N2|||http://purl.uniprot.org/uniprot/R4P3G9 ^@ Similarity ^@ Belongs to the RecJ family. http://togogenome.org/gene/243274:THEMA_RS03060 ^@ http://purl.uniprot.org/uniprot/R4NPX5 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily. http://togogenome.org/gene/243274:THEMA_RS03200 ^@ http://purl.uniprot.org/uniprot/Q9WYD7|||http://purl.uniprot.org/uniprot/R4NNB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS01690 ^@ http://purl.uniprot.org/uniprot/G4FDM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS07090 ^@ http://purl.uniprot.org/uniprot/G4FFG3|||http://purl.uniprot.org/uniprot/Q9X1E2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family.|||Cell membrane|||Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation.|||Membrane http://togogenome.org/gene/243274:THEMA_RS08265 ^@ http://purl.uniprot.org/uniprot/Q9X0S4|||http://purl.uniprot.org/uniprot/R4P2L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS00700 ^@ http://purl.uniprot.org/uniprot/Q9WZP7 ^@ Function|||Similarity ^@ Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.|||Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).|||In the C-terminal section; belongs to the ThiN family.|||In the N-terminal section; belongs to the ThiD family. http://togogenome.org/gene/243274:THEMA_RS06740 ^@ http://purl.uniprot.org/uniprot/G4FFN3|||http://purl.uniprot.org/uniprot/P38520 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/243274:THEMA_RS00170 ^@ http://purl.uniprot.org/uniprot/G4FCT2|||http://purl.uniprot.org/uniprot/Q9WZZ5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell inner membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS06325 ^@ http://purl.uniprot.org/uniprot/Q9X1R2|||http://purl.uniprot.org/uniprot/R4P3K4 ^@ Similarity ^@ Belongs to the TlyA family. http://togogenome.org/gene/243274:THEMA_RS02160 ^@ http://purl.uniprot.org/uniprot/Q9WYX3|||http://purl.uniprot.org/uniprot/R4NNU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS09110 ^@ http://purl.uniprot.org/uniprot/G4FEW6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS02045 ^@ http://purl.uniprot.org/uniprot/G4FDU5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Hfq family.|||Homohexamer.|||RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. http://togogenome.org/gene/243274:THEMA_RS01975 ^@ http://purl.uniprot.org/uniprot/Q9WZ10|||http://purl.uniprot.org/uniprot/R4NYQ7 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/243274:THEMA_RS07910 ^@ http://purl.uniprot.org/uniprot/Q9X0Z6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. HydE family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Monomer.|||Required for the maturation of the [FeFe]-hydrogenase HydA (By similarity). Catalyzes the reductive cleavage of S-adenosyl-L-methionine (in vitro), suggesting it may contribute to the biosynthesis of an essential sulfur-containing ligand that binds to the hydrogenase active site [2Fe-2S] cluster (PubMed:16137685). http://togogenome.org/gene/243274:THEMA_RS02235 ^@ http://purl.uniprot.org/uniprot/Q9WYV8 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.|||Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.|||Monomer and homodimer.|||The crystal structure corresponding to PDB 1SG9 shows a glutamate anhydride cross-link formed between the Glu-97 side chains from two molecules, but this has not been observed in other PrmC structures from T.maritima. This cross-link is suggested being an artifact of concentration during crystallization (PubMed:18247349). http://togogenome.org/gene/243274:THEMA_RS07240 ^@ http://purl.uniprot.org/uniprot/G4FFD5|||http://purl.uniprot.org/uniprot/Q9X1B9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/243274:THEMA_RS09445 ^@ http://purl.uniprot.org/uniprot/G4FF26|||http://purl.uniprot.org/uniprot/Q9X059 ^@ Function|||Similarity ^@ Belongs to the LarC family.|||Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. http://togogenome.org/gene/243274:THEMA_RS06795 ^@ http://purl.uniprot.org/uniprot/G4FFM2|||http://purl.uniprot.org/uniprot/Q9ZAE4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/243274:THEMA_RS06705 ^@ http://purl.uniprot.org/uniprot/G4FFP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS03255 ^@ http://purl.uniprot.org/uniprot/Q9WYC6|||http://purl.uniprot.org/uniprot/R4NXU6 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/243274:THEMA_RS06085 ^@ http://purl.uniprot.org/uniprot/Q9X1V3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CheC family.|||Homodimer.|||Involved in restoring normal CheY-P levels by dephosphorylating CheY-P. It has a greater activity than CheC. http://togogenome.org/gene/243274:THEMA_RS06460 ^@ http://purl.uniprot.org/uniprot/G4FFT7|||http://purl.uniprot.org/uniprot/Q9X1N5 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. WecA subfamily.|||Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55), the lipid intermediate involved in the synthesis of various bacterial cell envelope components. The enzyme is highly active when tested with C35-P, instead of its natural C55-P lipid substrate, suggesting that at least a 35-carbon chain is required for the lipid to be a substrate of WecA.|||Cell membrane|||Membrane|||Partially inhibited by magnesium at concentration higher than 10 mM and totally inhibited at concentration higher than 250 mM. Also inhibited by tunicamycin, NaCl and KCl. http://togogenome.org/gene/243274:THEMA_RS05505 ^@ http://purl.uniprot.org/uniprot/G4FGB9|||http://purl.uniprot.org/uniprot/Q9X255 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Homodimer.|||Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP (By similarity).|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS09075 ^@ http://purl.uniprot.org/uniprot/G4FEV9|||http://purl.uniprot.org/uniprot/Q9X0C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS06615 ^@ http://purl.uniprot.org/uniprot/G4FFQ8|||http://purl.uniprot.org/uniprot/Q9X1K9 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Is not inhibited by (S)-lysine, in contrast to E.coli DapA.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/243274:THEMA_RS08485 ^@ http://purl.uniprot.org/uniprot/G4FEJ2|||http://purl.uniprot.org/uniprot/Q9X0N9 ^@ Caution|||Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS07000 ^@ http://purl.uniprot.org/uniprot/G4FFI1|||http://purl.uniprot.org/uniprot/Q9X1F8 ^@ Domain|||Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||Each G (guanine nucleotide-binding) domain has activity on its own; domain 1 is twice as active as domain 2. The G domains do not interact, instead each contacts the C-terminal KH-like domain which lies between them.|||GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity). Has GTPase activity but no ATPase activity. GTP, GDP, and dGTP but not GMP, ATP, CTP, and UTP compete for GTP binding.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/243274:THEMA_RS02970 ^@ http://purl.uniprot.org/uniprot/G4FHQ8|||http://purl.uniprot.org/uniprot/Q9WYI1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). http://togogenome.org/gene/243274:THEMA_RS07250 ^@ http://purl.uniprot.org/uniprot/G4FFD3|||http://purl.uniprot.org/uniprot/Q9X1B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS02375 ^@ http://purl.uniprot.org/uniprot/Q9WYT5 ^@ Function ^@ Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. http://togogenome.org/gene/243274:THEMA_RS08350 ^@ http://purl.uniprot.org/uniprot/Q9X0R3|||http://purl.uniprot.org/uniprot/R4P0H8 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/243274:THEMA_RS01890 ^@ http://purl.uniprot.org/uniprot/G4FDR4|||http://purl.uniprot.org/uniprot/Q9WZ27 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS09065 ^@ http://purl.uniprot.org/uniprot/G4FEV7|||http://purl.uniprot.org/uniprot/Q9X0D1 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS00395 ^@ http://purl.uniprot.org/uniprot/G4FCX5|||http://purl.uniprot.org/uniprot/Q9WZV3 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/243274:THEMA_RS09060 ^@ http://purl.uniprot.org/uniprot/G4FEV6|||http://purl.uniprot.org/uniprot/Q9X0D2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATP phosphoribosyltransferase family. Short subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Heteromultimer composed of HisG and HisZ subunits.|||Lacks the C-terminal regulatory region which is replaced by HisZ. http://togogenome.org/gene/243274:THEMA_RS03470 ^@ http://purl.uniprot.org/uniprot/Q9WY89|||http://purl.uniprot.org/uniprot/R4NPQ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell inner membrane|||Membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/243274:THEMA_RS00050 ^@ http://purl.uniprot.org/uniprot/Q9X019|||http://purl.uniprot.org/uniprot/R4NZJ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS00155 ^@ http://purl.uniprot.org/uniprot/Q9WZZ8|||http://purl.uniprot.org/uniprot/R4P1Q6 ^@ Caution|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS00340 ^@ http://purl.uniprot.org/uniprot/G4FCW5|||http://purl.uniprot.org/uniprot/Q9WZW3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YajC family.|||Cell inner membrane|||Membrane|||Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).|||The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. http://togogenome.org/gene/243274:THEMA_RS08740 ^@ http://purl.uniprot.org/uniprot/Q9X0I9|||http://purl.uniprot.org/uniprot/R4NQI2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS07705 ^@ http://purl.uniprot.org/uniprot/Q9X137 ^@ Similarity ^@ Belongs to the UPF0150 family. http://togogenome.org/gene/243274:THEMA_RS07945 ^@ http://purl.uniprot.org/uniprot/Q9X0Y9|||http://purl.uniprot.org/uniprot/R4NSK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS05310 ^@ http://purl.uniprot.org/uniprot/G4FGF7|||http://purl.uniprot.org/uniprot/Q9X291 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family. DXPS subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS08415 ^@ http://purl.uniprot.org/uniprot/G4FEH8 ^@ Similarity ^@ Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/243274:THEMA_RS06710 ^@ http://purl.uniprot.org/uniprot/G4FFN9|||http://purl.uniprot.org/uniprot/P13537 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/243274:THEMA_RS02510 ^@ http://purl.uniprot.org/uniprot/Q9WYS1 ^@ Function|||Similarity ^@ Belongs to the UxaE family.|||Catalyzes the epimerization of D-tagaturonate (D-TagA) to D-fructuronate (D-FruA). http://togogenome.org/gene/243274:THEMA_RS04985 ^@ http://purl.uniprot.org/uniprot/Q9X2F4 ^@ Activity Regulation|||Function|||Similarity ^@ Belongs to the glycosyl hydrolase 13 family.|||Is able to hydrolyze various linear maltooligosaccharides (maltotriose to maltoheptaose) and cyclomaltodextrins (CDs), to mainly glucose and maltose, by liberating glucose from the reducing end of the molecules. Shows a very weak activity on starch. Can neither hydrolyze maltose nor degrade pullulan, but rapidly hydrolyzes acarbose, a strong amylase and glucosidase inhibitor, to acarviosine and glucose.|||Mn(2+), Co(2+), Zn(2+), Fe(2+), Mg(2+), and Ca(2+) inhibit the hydrolysis activity of the enzyme whereas EGTA and EDTA do not affect the activity. http://togogenome.org/gene/243274:THEMA_RS03440 ^@ http://purl.uniprot.org/uniprot/Q9WY95 ^@ Similarity ^@ Belongs to the UPF0102 family. http://togogenome.org/gene/243274:THEMA_RS06620 ^@ http://purl.uniprot.org/uniprot/G4FFQ7|||http://purl.uniprot.org/uniprot/Q9X1K8 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapB family.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (Probable). Uses NADPH as a reductant with much more efficiency than NADH.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.|||Cytoplasm|||Homotetramer.|||Is inhibited by high concentrations of NADH.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. http://togogenome.org/gene/243274:THEMA_RS00060 ^@ http://purl.uniprot.org/uniprot/G4FCR1|||http://purl.uniprot.org/uniprot/Q9X017 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/243274:THEMA_RS01005 ^@ http://purl.uniprot.org/uniprot/G4FD93|||http://purl.uniprot.org/uniprot/Q9WZI9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS05550 ^@ http://purl.uniprot.org/uniprot/G4FGB1|||http://purl.uniprot.org/uniprot/Q9X248 ^@ Function|||Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.|||Homotetramer. http://togogenome.org/gene/243274:THEMA_RS01635 ^@ http://purl.uniprot.org/uniprot/G4FDL4|||http://purl.uniprot.org/uniprot/Q9WZ74 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6. http://togogenome.org/gene/243274:THEMA_RS03520 ^@ http://purl.uniprot.org/uniprot/G4FHF1|||http://purl.uniprot.org/uniprot/Q9WY79 ^@ Caution|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurE subfamily.|||Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.|||Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.|||Catalyzes the addition of both L- and D-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use meso-diaminopimelate as the amino acid substrate in vitro, although much less efficiently.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The peptidoglycan of T.maritima was shown to contain approximate amounts of both enantiomers of lysine and no diaminopimelate. http://togogenome.org/gene/243274:THEMA_RS00200 ^@ http://purl.uniprot.org/uniprot/G4FCT8 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGMT family.|||Cytoplasm|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.|||This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. http://togogenome.org/gene/243274:THEMA_RS09485 ^@ http://purl.uniprot.org/uniprot/Q9X051 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.|||Cell inner membrane|||Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system.|||The complex is composed of an ATP-binding protein (RbsA), two transmembrane proteins (RbsC) and a solute-binding protein (RbsB). http://togogenome.org/gene/243274:THEMA_RS06630 ^@ http://purl.uniprot.org/uniprot/Q9X1K6|||http://purl.uniprot.org/uniprot/R4NRK9 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/243274:THEMA_RS06355 ^@ http://purl.uniprot.org/uniprot/Q9X1Q6 ^@ Similarity ^@ To A.aeolicus AQ_054. http://togogenome.org/gene/243274:THEMA_RS05430 ^@ http://purl.uniprot.org/uniprot/Q9X270|||http://purl.uniprot.org/uniprot/R4NSC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS02540 ^@ http://purl.uniprot.org/uniprot/Q9WYR5|||http://purl.uniprot.org/uniprot/R4NQ64 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 4 family.|||Binds 1 NAD(+) per subunit. http://togogenome.org/gene/243274:THEMA_RS06915 ^@ http://purl.uniprot.org/uniprot/G4FFJ8|||http://purl.uniprot.org/uniprot/Q9X1H4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RnpA family.|||Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.|||RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. http://togogenome.org/gene/243274:THEMA_RS05015 ^@ http://purl.uniprot.org/uniprot/Q9X2E8|||http://purl.uniprot.org/uniprot/R4P2B8 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion.|||Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.|||In the C-terminal section; belongs to the HTP reductase family.|||In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/243274:THEMA_RS03355 ^@ http://purl.uniprot.org/uniprot/Q9WYA7|||http://purl.uniprot.org/uniprot/R4NXT0 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/243274:THEMA_RS08390 ^@ http://purl.uniprot.org/uniprot/Q9X0Q5|||http://purl.uniprot.org/uniprot/R4P075 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.|||Membrane http://togogenome.org/gene/243274:THEMA_RS05840 ^@ http://purl.uniprot.org/uniprot/G4FG56|||http://purl.uniprot.org/uniprot/Q9X1Z5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xylose isomerase family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/243274:THEMA_RS06510 ^@ http://purl.uniprot.org/uniprot/G4FFS8|||http://purl.uniprot.org/uniprot/Q9X1M6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.|||Bacterial flagellum basal body|||Belongs to the FlgH family.|||Cell outer membrane|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. http://togogenome.org/gene/243274:THEMA_RS09050 ^@ http://purl.uniprot.org/uniprot/G4FEV4 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/243274:THEMA_RS00350 ^@ http://purl.uniprot.org/uniprot/Q9WZW1|||http://purl.uniprot.org/uniprot/R4NZD4 ^@ Similarity ^@ Belongs to the ribF family. http://togogenome.org/gene/243274:THEMA_RS01135 ^@ http://purl.uniprot.org/uniprot/Q9WZG5|||http://purl.uniprot.org/uniprot/R4NR00 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS08080 ^@ http://purl.uniprot.org/uniprot/Q9X0W1|||http://purl.uniprot.org/uniprot/R4NQY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS04280 ^@ http://purl.uniprot.org/uniprot/Q9WXV1|||http://purl.uniprot.org/uniprot/R4NX84 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/243274:THEMA_RS02190 ^@ http://purl.uniprot.org/uniprot/Q9WYW7|||http://purl.uniprot.org/uniprot/R4NYB7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS07270 ^@ http://purl.uniprot.org/uniprot/G4FFC9|||http://purl.uniprot.org/uniprot/Q9X1B3 ^@ Function|||Similarity ^@ Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). http://togogenome.org/gene/243274:THEMA_RS06045 ^@ http://purl.uniprot.org/uniprot/G4FG15|||http://purl.uniprot.org/uniprot/Q9X1W1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/243274:THEMA_RS05655 ^@ http://purl.uniprot.org/uniprot/Q9X229|||http://purl.uniprot.org/uniprot/R4NS51 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS03410 ^@ http://purl.uniprot.org/uniprot/P46805|||http://purl.uniprot.org/uniprot/R4P006 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the D-alanine--D-alanine ligase family.|||Binds 2 magnesium or manganese ions per subunit.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS03635 ^@ http://purl.uniprot.org/uniprot/G4FHC8|||http://purl.uniprot.org/uniprot/Q9WY57 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. C-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/243274:THEMA_RS09230 ^@ http://purl.uniprot.org/uniprot/G4FEY9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS06100 ^@ http://purl.uniprot.org/uniprot/G4FG04 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase A chain family.|||Cell inner membrane|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.|||Membrane http://togogenome.org/gene/243274:THEMA_RS06220 ^@ http://purl.uniprot.org/uniprot/G4FFY0|||http://purl.uniprot.org/uniprot/Q9X1S8 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity).|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/243274:THEMA_RS05055 ^@ http://purl.uniprot.org/uniprot/G4FGK7|||http://purl.uniprot.org/uniprot/Q9X2E0 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS08855 ^@ http://purl.uniprot.org/uniprot/G4FER5|||http://purl.uniprot.org/uniprot/Q9X0H1 ^@ Function|||Similarity ^@ Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity). May also act as a chaperone or modulator of proteins involved in DNA or RNA processing.|||Belongs to the archease family. http://togogenome.org/gene/243274:THEMA_RS04010 ^@ http://purl.uniprot.org/uniprot/G4FH64|||http://purl.uniprot.org/uniprot/Q9WXZ7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/243274:THEMA_RS02125 ^@ http://purl.uniprot.org/uniprot/Q9WYY1 ^@ Domain|||Function|||Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.|||Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP. Can remove uracil from double-stranded DNA containing either a U/G or U/A base pair as well as from single-stranded DNA.|||The seven N-terminal amino acids are important for maintaining proper protein folding and increase temperature stability of the protein. http://togogenome.org/gene/243274:THEMA_RS01055 ^@ http://purl.uniprot.org/uniprot/G4FDA2|||http://purl.uniprot.org/uniprot/Q9WZI0 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/243274:THEMA_RS01820 ^@ http://purl.uniprot.org/uniprot/Q9WZ40|||http://purl.uniprot.org/uniprot/R4P0U1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell inner membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Membrane|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/243274:THEMA_RS08795 ^@ http://purl.uniprot.org/uniprot/G4FEQ3|||http://purl.uniprot.org/uniprot/Q9X0H9 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/243274:THEMA_RS02555 ^@ http://purl.uniprot.org/uniprot/Q9WYR2|||http://purl.uniprot.org/uniprot/R4P0F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS09465 ^@ http://purl.uniprot.org/uniprot/G4FF30 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/243274:THEMA_RS06925 ^@ http://purl.uniprot.org/uniprot/Q9X1H2|||http://purl.uniprot.org/uniprot/R4NT21 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.|||Cell inner membrane|||Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.|||Membrane|||Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. http://togogenome.org/gene/243274:THEMA_RS01270 ^@ http://purl.uniprot.org/uniprot/Q9WZE6|||http://purl.uniprot.org/uniprot/R4NYV6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the FliM family.|||Cell inner membrane|||FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheX chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).|||Interacts (via N-terminus) with unphosphorylated CheY. Interacts (via central domain) with FliG (via central domain or via central domain and C-terminus).|||Membrane http://togogenome.org/gene/243274:THEMA_RS04660 ^@ http://purl.uniprot.org/uniprot/G4FGT6|||http://purl.uniprot.org/uniprot/Q9WXM8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.|||Cell inner membrane|||Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane|||Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function. http://togogenome.org/gene/243274:THEMA_RS09460 ^@ http://purl.uniprot.org/uniprot/G4FF29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/243274:THEMA_RS00630 ^@ http://purl.uniprot.org/uniprot/G4FD20|||http://purl.uniprot.org/uniprot/Q9WZR1 ^@ Similarity ^@ Belongs to the PHP hydrolase family. HisK subfamily. http://togogenome.org/gene/243274:THEMA_RS02390 ^@ http://purl.uniprot.org/uniprot/Q9WYT2|||http://purl.uniprot.org/uniprot/R4NYI8 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 5 family. http://togogenome.org/gene/243274:THEMA_RS02040 ^@ http://purl.uniprot.org/uniprot/Q9WYZ7|||http://purl.uniprot.org/uniprot/R4NYE3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/243274:THEMA_RS07770 ^@ http://purl.uniprot.org/uniprot/G4FE53 ^@ Similarity ^@ Belongs to the RNase H family. http://togogenome.org/gene/243274:THEMA_RS03480 ^@ http://purl.uniprot.org/uniprot/Q9WY87|||http://purl.uniprot.org/uniprot/R4NXR2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrB/RnfD family.|||Cell inner membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/243274:THEMA_RS02890 ^@ http://purl.uniprot.org/uniprot/Q9WYJ7|||http://purl.uniprot.org/uniprot/R4NNF8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AP endonuclease 2 family.|||Binds 3 Zn(2+) ions.|||Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. http://togogenome.org/gene/243274:THEMA_RS06830 ^@ http://purl.uniprot.org/uniprot/Q9X1I7|||http://purl.uniprot.org/uniprot/R4NRH3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/243274:THEMA_RS01025 ^@ http://purl.uniprot.org/uniprot/Q9WZI6|||http://purl.uniprot.org/uniprot/R4P1D0 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/243274:THEMA_RS01915 ^@ http://purl.uniprot.org/uniprot/G4FDR9|||http://purl.uniprot.org/uniprot/Q9WZ22 ^@ Function|||Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family.|||Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate. http://togogenome.org/gene/243274:THEMA_RS00355 ^@ http://purl.uniprot.org/uniprot/G4FCW8|||http://purl.uniprot.org/uniprot/Q9WZW0 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/243274:THEMA_RS02615 ^@ http://purl.uniprot.org/uniprot/Q9WYQ0|||http://purl.uniprot.org/uniprot/R4NQ53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS03535 ^@ http://purl.uniprot.org/uniprot/G4FHE8|||http://purl.uniprot.org/uniprot/Q9WY76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS07740 ^@ http://purl.uniprot.org/uniprot/Q9X129|||http://purl.uniprot.org/uniprot/R4P0M0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS03705 ^@ http://purl.uniprot.org/uniprot/G4FHB4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DisA family.|||Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.|||Homooctamer.|||Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions. http://togogenome.org/gene/243274:THEMA_RS04485 ^@ http://purl.uniprot.org/uniprot/G4FGX0|||http://purl.uniprot.org/uniprot/P96105 ^@ Function|||Similarity|||Subunit ^@ Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. It catalyzes the cleavage of alpha-(1->2)-glycosidic bond of the 4-O-methyl-D-glucuronic acid side chain of xylan and releases 4-O-methylglucuronic acid from xylan.|||Belongs to the glycosyl hydrolase 67 family.|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS08650 ^@ http://purl.uniprot.org/uniprot/G4FEM5|||http://purl.uniprot.org/uniprot/Q9X0K7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum|||Belongs to the FliD family.|||Homopentamer.|||Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.|||Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity).|||Secreted http://togogenome.org/gene/243274:THEMA_RS01120 ^@ http://purl.uniprot.org/uniprot/G4FDB5|||http://purl.uniprot.org/uniprot/Q9WZG8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmI family.|||Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS04200 ^@ http://purl.uniprot.org/uniprot/Q9WXW7|||http://purl.uniprot.org/uniprot/R4NMR7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS03550 ^@ http://purl.uniprot.org/uniprot/G4FHE5|||http://purl.uniprot.org/uniprot/Q9WY73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS04765 ^@ http://purl.uniprot.org/uniprot/Q9X2I6 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/243274:THEMA_RS05575 ^@ http://purl.uniprot.org/uniprot/G4FGA6|||http://purl.uniprot.org/uniprot/P74926 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity).|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. http://togogenome.org/gene/243274:THEMA_RS06190 ^@ http://purl.uniprot.org/uniprot/Q9X1T4|||http://purl.uniprot.org/uniprot/R4NRU1 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/243274:THEMA_RS04345 ^@ http://purl.uniprot.org/uniprot/Q9WXT8|||http://purl.uniprot.org/uniprot/R4NP99 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum|||Belongs to the flagella basal body rod proteins family.|||Secreted http://togogenome.org/gene/243274:THEMA_RS06800 ^@ http://purl.uniprot.org/uniprot/G4FFM1|||http://purl.uniprot.org/uniprot/Q9ZAE3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/243274:THEMA_RS04080 ^@ http://purl.uniprot.org/uniprot/G4FH51|||http://purl.uniprot.org/uniprot/P50908 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/243274:THEMA_RS06535 ^@ http://purl.uniprot.org/uniprot/Q9X1M1|||http://purl.uniprot.org/uniprot/R4P1F4 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/243274:THEMA_RS00740 ^@ http://purl.uniprot.org/uniprot/Q9WZN9|||http://purl.uniprot.org/uniprot/R4P1G4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 130 family. http://togogenome.org/gene/243274:THEMA_RS06375 ^@ http://purl.uniprot.org/uniprot/G4FFV4|||http://purl.uniprot.org/uniprot/Q9X1Q2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/243274:THEMA_RS08170 ^@ http://purl.uniprot.org/uniprot/Q9X0U3|||http://purl.uniprot.org/uniprot/R4P0M1 ^@ Similarity ^@ Belongs to the complex I 49 kDa subunit family. http://togogenome.org/gene/243274:THEMA_RS03405 ^@ http://purl.uniprot.org/uniprot/Q9WY98|||http://purl.uniprot.org/uniprot/R4NXS3 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/243274:THEMA_RS08070 ^@ http://purl.uniprot.org/uniprot/Q9X0W4|||http://purl.uniprot.org/uniprot/R4P0R4 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/243274:THEMA_RS03070 ^@ http://purl.uniprot.org/uniprot/Q9WYG2|||http://purl.uniprot.org/uniprot/R4NND3 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/243274:THEMA_RS08320 ^@ http://purl.uniprot.org/uniprot/Q9X0R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS04240 ^@ http://purl.uniprot.org/uniprot/Q9WXV9|||http://purl.uniprot.org/uniprot/R4NXK0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS02695 ^@ http://purl.uniprot.org/uniprot/Q9WYN4|||http://purl.uniprot.org/uniprot/R4NNJ3 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/243274:THEMA_RS02140 ^@ http://purl.uniprot.org/uniprot/Q9WYX8 ^@ Similarity ^@ In the N-terminal section; belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. http://togogenome.org/gene/243274:THEMA_RS06200 ^@ http://purl.uniprot.org/uniprot/Q9X1T2|||http://purl.uniprot.org/uniprot/R4P3M7 ^@ Function|||Similarity ^@ Belongs to the PNP/MTAP phosphorylase family.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/243274:THEMA_RS07105 ^@ http://purl.uniprot.org/uniprot/O52682 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 51 kDa subunit family.|||Binds 1 FMN per subunit.|||Catalyzes the oxidation of the physiological electron carriers NADH and reduced ferredoxin, coupled to the production of H(2) (PubMed:19411328). Acts as a bifurcating [FeFe] hydrogenase, which uses the exergonic oxidation of reduced ferredoxin to drive the unfavorable oxidation of NADH to produce H(2) (PubMed:19411328). The beta subunit contains flavin- and NAD-binding sites and is potentially the site for NADH oxidation, with the subsequent shuttling of electrons to the alpha subunit (PubMed:19411328).|||Cytoplasm|||Heterotrimer composed of HydA (alpha subunit), HydB (beta subunit) and HydC (gamma subunit) (PubMed:10482784). Near neutral and acidic pH conditions favor oligomerization of the heterotrimeric holoenzyme (PubMed:10482784).|||May bind 1 [2Fe-2S] cluster per subunit.|||May bind 3 [4Fe-4S] cluster per subunit. http://togogenome.org/gene/243274:THEMA_RS03890 ^@ http://purl.uniprot.org/uniprot/G4FH88|||http://purl.uniprot.org/uniprot/Q9S5X0 ^@ Activity Regulation|||Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.|||Cell inner membrane|||Has 16 transmembrane helices and a cytoplasmic domain that contains the active site. Pyrophosphate binding is thought to trigger a conformation change that allows Na(+) release. Has at least two binding sites for Na(+) (PubMed:22837527).|||Homodimer.|||Inhibited by GdCl3. Requires K(+) for maximal activity. K(+) greatly stimulates Na(+) binding. Thermostability depends on the binding of Mg(2+).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Requires K(+) for maximal activity.|||Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane. http://togogenome.org/gene/243274:THEMA_RS03450 ^@ http://purl.uniprot.org/uniprot/Q9WY93|||http://purl.uniprot.org/uniprot/R4NN87 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.|||Belongs to the CsrA/RsmA family.|||Cytoplasm|||Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core. http://togogenome.org/gene/243274:THEMA_RS04790 ^@ http://purl.uniprot.org/uniprot/Q9X2I1|||http://purl.uniprot.org/uniprot/R4P2F7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the energy-coupling factor EcfT family.|||Cell inner membrane|||Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component, RibU, BioY), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component) upon coexpression in E.coli. A stable subcomplex with both A and T components are also isolated. This complex interacts with at least 2 substrate-specific components, BioY and RibU.|||Membrane|||Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (Probable). Expression of the complex plus RibU in E.coli allows riboflavin uptake; uptake does not occur in the absence of RibU or the EcfA1A2T complex. http://togogenome.org/gene/243274:THEMA_RS08180 ^@ http://purl.uniprot.org/uniprot/Q9X0U1|||http://purl.uniprot.org/uniprot/R4NQU1 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/243274:THEMA_RS07890 ^@ http://purl.uniprot.org/uniprot/G4FE75|||http://purl.uniprot.org/uniprot/Q9X100 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity).|||Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/243274:THEMA_RS08140 ^@ http://purl.uniprot.org/uniprot/Q9X0U9|||http://purl.uniprot.org/uniprot/R4P2R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS01625 ^@ http://purl.uniprot.org/uniprot/G4FDL2 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family. http://togogenome.org/gene/243274:THEMA_RS00220 ^@ http://purl.uniprot.org/uniprot/G4FCU2|||http://purl.uniprot.org/uniprot/Q9WZY5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A monovalent cation. Ammonium or potassium.|||Belongs to the type III pantothenate kinase family.|||Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS03365 ^@ http://purl.uniprot.org/uniprot/Q9WYA5|||http://purl.uniprot.org/uniprot/R4NY42 ^@ Function|||Similarity ^@ Belongs to the vitamin-B12 dependent methionine synthase family.|||Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. http://togogenome.org/gene/243274:THEMA_RS00390 ^@ http://purl.uniprot.org/uniprot/G4FCX4|||http://purl.uniprot.org/uniprot/Q9WZV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/243274:THEMA_RS06790 ^@ http://purl.uniprot.org/uniprot/G4FFM3|||http://purl.uniprot.org/uniprot/Q9ZAE5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/243274:THEMA_RS03680 ^@ http://purl.uniprot.org/uniprot/R4NXJ6 ^@ Function|||Similarity ^@ Belongs to the helicase family. RecG subfamily.|||Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). http://togogenome.org/gene/243274:THEMA_RS01895 ^@ http://purl.uniprot.org/uniprot/G4FDR5|||http://purl.uniprot.org/uniprot/Q9WZ26 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS04685 ^@ http://purl.uniprot.org/uniprot/O05650 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/243274:THEMA_RS04325 ^@ http://purl.uniprot.org/uniprot/G4FH02|||http://purl.uniprot.org/uniprot/Q9WXU2 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/243274:THEMA_RS04710 ^@ http://purl.uniprot.org/uniprot/Q9WXM5|||http://purl.uniprot.org/uniprot/R4NZA7 ^@ Similarity ^@ Belongs to the complex I 51 kDa subunit family. http://togogenome.org/gene/243274:THEMA_RS03505 ^@ http://purl.uniprot.org/uniprot/G4FHF4|||http://purl.uniprot.org/uniprot/Q9WY82 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.|||Homotetramer.|||Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. http://togogenome.org/gene/243274:THEMA_RS01950 ^@ http://purl.uniprot.org/uniprot/G4FDS6|||http://purl.uniprot.org/uniprot/Q9WZ15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS00255 ^@ http://purl.uniprot.org/uniprot/Q9WZX9|||http://purl.uniprot.org/uniprot/R4P1P0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS02480 ^@ http://purl.uniprot.org/uniprot/G4FE24|||http://purl.uniprot.org/uniprot/Q9WYS7 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/243274:THEMA_RS07950 ^@ http://purl.uniprot.org/uniprot/Q9X0Y8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.|||Cell inner membrane|||Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS). http://togogenome.org/gene/243274:THEMA_RS00720 ^@ http://purl.uniprot.org/uniprot/Q9WZP3 ^@ Biotechnology|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ferritin-like superfamily.|||Cargo protein of a type 1 encapsulin nanocompartment. A ferritin-like protein that probably stores iron in the encapsulin nanocompartment.|||Encapsulin nanocompartment|||Probably forms a decamer which binds to the pentameric axis of the interior of the protein shell; as the Flp cargo protein is flexible, packing into the shell is not rigid. 3, 4 or 5 cargo decamers bind inside the encapulin nanocompartment (PubMed:34815415).|||The 15 or 30 C-terminal residues can be used to target foreign proteins to the nanocompartment.|||The C-terminal 15-30 residues (cargo loading-peptide, CLP, or targeting peptide) are sufficient to target this protein to the nanocompartment in vivo, while the C-terminal 5 residues suffice in vitro. http://togogenome.org/gene/243274:THEMA_RS09005 ^@ http://purl.uniprot.org/uniprot/Q9X0E3|||http://purl.uniprot.org/uniprot/R4NRW6 ^@ Similarity ^@ Belongs to the Skp family. http://togogenome.org/gene/243274:THEMA_RS01400 ^@ http://purl.uniprot.org/uniprot/G4FDH1|||http://purl.uniprot.org/uniprot/Q9WZC1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methylthiotransferase family. MiaB subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.|||Cytoplasm|||Monomer. http://togogenome.org/gene/243274:THEMA_RS06585 ^@ http://purl.uniprot.org/uniprot/G4FFR3|||http://purl.uniprot.org/uniprot/Q7DF96 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 12 (cellulase H) family. http://togogenome.org/gene/243274:THEMA_RS05115 ^@ http://purl.uniprot.org/uniprot/Q9X2C7|||http://purl.uniprot.org/uniprot/R4P2A1 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated Csm5 family.|||This subunit might be involved in maturation of a crRNA intermediate to its mature form. http://togogenome.org/gene/243274:THEMA_RS04820 ^@ http://purl.uniprot.org/uniprot/G4FGQ4|||http://purl.uniprot.org/uniprot/Q9X2H6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methylthiotransferase family. RimO subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. The two iron atoms in each cluster are connected via a penta-sulfide bridge.|||Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.|||Cytoplasm|||Monomer. http://togogenome.org/gene/243274:THEMA_RS06745 ^@ http://purl.uniprot.org/uniprot/P38511 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). http://togogenome.org/gene/243274:THEMA_RS00310 ^@ http://purl.uniprot.org/uniprot/Q9WZW9|||http://purl.uniprot.org/uniprot/R4NZN1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS01000 ^@ http://purl.uniprot.org/uniprot/G4FD92 ^@ Function|||Similarity ^@ Belongs to the QueH family.|||Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). http://togogenome.org/gene/243274:THEMA_RS03040 ^@ http://purl.uniprot.org/uniprot/G4FHP5|||http://purl.uniprot.org/uniprot/Q9WYG7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the OMP decarboxylase family.|||Belongs to the OMP decarboxylase family. Type 1 subfamily.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS01985 ^@ http://purl.uniprot.org/uniprot/Q9WZ08|||http://purl.uniprot.org/uniprot/R4NNY1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS03930 ^@ http://purl.uniprot.org/uniprot/Q9WY13 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/243274:THEMA_RS05415 ^@ http://purl.uniprot.org/uniprot/Q9X273|||http://purl.uniprot.org/uniprot/R4P461 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/243274:THEMA_RS00250 ^@ http://purl.uniprot.org/uniprot/P42848 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Homooctamer. Forms a ring-shaped particle.|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein (By similarity). Inhibited by fluoride and phosphate. http://togogenome.org/gene/243274:THEMA_RS06905 ^@ http://purl.uniprot.org/uniprot/G4FFK0|||http://purl.uniprot.org/uniprot/Q9X1H5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the pseudouridine-5'-phosphate glycosidase family.|||Binds 1 Mn(2+) ion per subunit.|||Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil.|||Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.|||Homotrimer. http://togogenome.org/gene/243274:THEMA_RS03620 ^@ http://purl.uniprot.org/uniprot/G4FHD1|||http://purl.uniprot.org/uniprot/Q9WY60 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/243274:THEMA_RS01945 ^@ http://purl.uniprot.org/uniprot/Q9WZ16 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/243274:THEMA_RS04410 ^@ http://purl.uniprot.org/uniprot/Q9WXS5|||http://purl.uniprot.org/uniprot/R4NZG5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 10 (cellulase F) family. http://togogenome.org/gene/243274:THEMA_RS06975 ^@ http://purl.uniprot.org/uniprot/G4FFI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoD/SigA subfamily.|||Cytoplasm|||Interacts transiently with the RNA polymerase catalytic core.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. http://togogenome.org/gene/243274:THEMA_RS06145 ^@ http://purl.uniprot.org/uniprot/Q9X1U3|||http://purl.uniprot.org/uniprot/R4P1D3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.|||Cytoplasm|||Interacts with 100S ribosomes.|||Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. http://togogenome.org/gene/243274:THEMA_RS08260 ^@ http://purl.uniprot.org/uniprot/Q9X0S5|||http://purl.uniprot.org/uniprot/R4P0A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS02250 ^@ http://purl.uniprot.org/uniprot/Q9WYV5|||http://purl.uniprot.org/uniprot/R4NYK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS02400 ^@ http://purl.uniprot.org/uniprot/P29398 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/243274:THEMA_RS08870 ^@ http://purl.uniprot.org/uniprot/Q9X0G9|||http://purl.uniprot.org/uniprot/R4P285 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/243274:THEMA_RS02925 ^@ http://purl.uniprot.org/uniprot/Q9WYJ0|||http://purl.uniprot.org/uniprot/R4P086 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/243274:THEMA_RS00840 ^@ http://purl.uniprot.org/uniprot/G4FD61|||http://purl.uniprot.org/uniprot/Q9WZM1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/243274:THEMA_RS08785 ^@ http://purl.uniprot.org/uniprot/G4FEQ1|||http://purl.uniprot.org/uniprot/Q9X0I1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/243274:THEMA_RS05645 ^@ http://purl.uniprot.org/uniprot/G4FG92|||http://purl.uniprot.org/uniprot/Q9X231 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS00810 ^@ http://purl.uniprot.org/uniprot/G4FD55|||http://purl.uniprot.org/uniprot/Q9WZM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.|||Cytoplasm|||Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.|||Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity. Binds to the 23S rRNA (By similarity). http://togogenome.org/gene/243274:THEMA_RS01045 ^@ http://purl.uniprot.org/uniprot/Q9WZI2|||http://purl.uniprot.org/uniprot/R4NZ23 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/243274:THEMA_RS04290 ^@ http://purl.uniprot.org/uniprot/Q9WXU9|||http://purl.uniprot.org/uniprot/R4NXJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Membrane http://togogenome.org/gene/243274:THEMA_RS08780 ^@ http://purl.uniprot.org/uniprot/G4FEQ0|||http://purl.uniprot.org/uniprot/P96108 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. http://togogenome.org/gene/243274:THEMA_RS01885 ^@ http://purl.uniprot.org/uniprot/G4FDR3|||http://purl.uniprot.org/uniprot/Q9WZ28 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/243274:THEMA_RS02335 ^@ http://purl.uniprot.org/uniprot/G4FDZ8|||http://purl.uniprot.org/uniprot/Q9WYU3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/243274:THEMA_RS01700 ^@ http://purl.uniprot.org/uniprot/Q9WZ61|||http://purl.uniprot.org/uniprot/R4NQM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS04700 ^@ http://purl.uniprot.org/uniprot/G4FGS8 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/243274:THEMA_RS06720 ^@ http://purl.uniprot.org/uniprot/G4FFN7|||http://purl.uniprot.org/uniprot/P38515 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/243274:THEMA_RS04020 ^@ http://purl.uniprot.org/uniprot/G4FH62|||http://purl.uniprot.org/uniprot/Q9WXZ5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS04645 ^@ http://purl.uniprot.org/uniprot/Q9WXN0|||http://purl.uniprot.org/uniprot/R4NP39 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/243274:THEMA_RS02015 ^@ http://purl.uniprot.org/uniprot/Q9WZ02|||http://purl.uniprot.org/uniprot/R4NYE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS00635 ^@ http://purl.uniprot.org/uniprot/G4FD21|||http://purl.uniprot.org/uniprot/Q9WZR0 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS09600 ^@ http://purl.uniprot.org/uniprot/Q9X032|||http://purl.uniprot.org/uniprot/R4NRK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CitM (TC 2.A.11) transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS04150 ^@ http://purl.uniprot.org/uniprot/Q9WXX6|||http://purl.uniprot.org/uniprot/R4NPD7 ^@ Cofactor|||Similarity ^@ Belongs to the Fur family.|||Binds 1 Mn(2+) or Fe(2+) ion per subunit.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/243274:THEMA_RS04730 ^@ http://purl.uniprot.org/uniprot/G4FGS2|||http://purl.uniprot.org/uniprot/Q9WXM1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the mandelate racemase/muconate lactonizing enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the epimerization of L-Ala-D-Glu to L-Ala-L-Glu and has probably a role in the metabolism of the murein peptide, of which L-Ala-D-Glu is a component. Is also able to catalyze the reverse reaction and the epimerization of a broad range of other dipeptides; is most efficient with L-Ala-D/L-Phe, L-Ala-D/L-Tyr, and L-Ala-D/L-His. http://togogenome.org/gene/243274:THEMA_RS05320 ^@ http://purl.uniprot.org/uniprot/G4FGF5|||http://purl.uniprot.org/uniprot/Q9X289 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseA family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/243274:THEMA_RS04655 ^@ http://purl.uniprot.org/uniprot/G4FGT7|||http://purl.uniprot.org/uniprot/Q9WXM9 ^@ Similarity ^@ Belongs to the UPF0166 family. http://togogenome.org/gene/243274:THEMA_RS03645 ^@ http://purl.uniprot.org/uniprot/Q9WY55|||http://purl.uniprot.org/uniprot/R4NPL5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/243274:THEMA_RS09505 ^@ http://purl.uniprot.org/uniprot/G4FF38|||http://purl.uniprot.org/uniprot/Q9X049 ^@ Activity Regulation|||Caution|||Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Inhibited by fructose 1,6-bisphosphate (FBP).|||Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS01150 ^@ http://purl.uniprot.org/uniprot/G4FDC1|||http://purl.uniprot.org/uniprot/Q9S5X1 ^@ Similarity ^@ Belongs to the CinA family. http://togogenome.org/gene/243274:THEMA_RS03640 ^@ http://purl.uniprot.org/uniprot/G4FHC7|||http://purl.uniprot.org/uniprot/Q9WY56 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. N-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/243274:THEMA_RS06980 ^@ http://purl.uniprot.org/uniprot/Q9X1G2|||http://purl.uniprot.org/uniprot/R4NRE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.|||Cytoplasm|||In the C-terminal section; belongs to the helicase family. RecG subfamily.|||In the N-terminal section; belongs to the UvrB family. http://togogenome.org/gene/243274:THEMA_RS05890 ^@ http://purl.uniprot.org/uniprot/G4FG46|||http://purl.uniprot.org/uniprot/Q9X1Y7 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/243274:THEMA_RS06195 ^@ http://purl.uniprot.org/uniprot/Q9X1T3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the alanine racemase family.|||Catalyzes the interconversion of D-lysine and L-lysine. Has also high activity toward ornithine, and weaker activity toward alanine. Contributes to production of D-lysine and D-alanine for use as peptidoglycan components.|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS08125 ^@ http://purl.uniprot.org/uniprot/Q9X0V2|||http://purl.uniprot.org/uniprot/R4NSH8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 130 family. http://togogenome.org/gene/243274:THEMA_RS06880 ^@ http://purl.uniprot.org/uniprot/Q9X1H9 ^@ Function|||Subunit ^@ Binds long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.|||Monomer. http://togogenome.org/gene/243274:THEMA_RS05050 ^@ http://purl.uniprot.org/uniprot/G4FGK8|||http://purl.uniprot.org/uniprot/Q9X2E1 ^@ Function|||Similarity ^@ Belongs to the type-2 OGG1 family.|||Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites). http://togogenome.org/gene/243274:THEMA_RS02415 ^@ http://purl.uniprot.org/uniprot/G4FE15|||http://purl.uniprot.org/uniprot/P29393 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/243274:THEMA_RS08745 ^@ http://purl.uniprot.org/uniprot/Q9X0I8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS04860 ^@ http://purl.uniprot.org/uniprot/Q9X2G9|||http://purl.uniprot.org/uniprot/R4P4D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS01275 ^@ http://purl.uniprot.org/uniprot/Q9WZE5|||http://purl.uniprot.org/uniprot/R4P156 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FliL family.|||Cell membrane|||Controls the rotational direction of flagella during chemotaxis.|||Membrane http://togogenome.org/gene/243274:THEMA_RS01370 ^@ http://purl.uniprot.org/uniprot/Q9WZC7|||http://purl.uniprot.org/uniprot/R4NYT3 ^@ Cofactor|||Similarity ^@ Belongs to the rubredoxin family.|||Binds 1 Fe(3+) ion per subunit. http://togogenome.org/gene/243274:THEMA_RS03510 ^@ http://purl.uniprot.org/uniprot/Q9WY81|||http://purl.uniprot.org/uniprot/R4NZZ2 ^@ Similarity ^@ Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. http://togogenome.org/gene/243274:THEMA_RS01065 ^@ http://purl.uniprot.org/uniprot/G4FDA4|||http://purl.uniprot.org/uniprot/Q9WZH8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. http://togogenome.org/gene/243274:THEMA_RS02420 ^@ http://purl.uniprot.org/uniprot/G4FE16|||http://purl.uniprot.org/uniprot/P29395 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which 3 L12 dimers bind in a sequential fashion forming a heptameric L10(L12)2(L12)2(L12)2 complex.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/243274:THEMA_RS07935 ^@ http://purl.uniprot.org/uniprot/Q9X0Z1|||http://purl.uniprot.org/uniprot/R4P2U2 ^@ Function|||Similarity ^@ Belongs to the PstS family.|||Involved in the system for phosphate transport across the cytoplasmic membrane. http://togogenome.org/gene/243274:THEMA_RS07345 ^@ http://purl.uniprot.org/uniprot/Q9X1A0|||http://purl.uniprot.org/uniprot/R4NSV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/243274:THEMA_RS06370 ^@ http://purl.uniprot.org/uniprot/G4FFV5|||http://purl.uniprot.org/uniprot/Q9X1Q3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.|||Belongs to the KhpA RNA-binding protein family.|||Cytoplasm|||Forms a complex with KhpB. http://togogenome.org/gene/243274:THEMA_RS04430 ^@ http://purl.uniprot.org/uniprot/G4FGY1 ^@ Similarity ^@ Belongs to the KHG/KDPG aldolase family. http://togogenome.org/gene/243274:THEMA_RS05065 ^@ http://purl.uniprot.org/uniprot/Q9X2D8|||http://purl.uniprot.org/uniprot/R4P2B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/243274:THEMA_RS00725 ^@ http://purl.uniprot.org/uniprot/G4FD39|||http://purl.uniprot.org/uniprot/Q9WZP2 ^@ Activity Regulation|||Biotechnology|||Cofactor|||Domain|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A flavin ligand is bound near the 3-fold axis channel; FMN is consistent with the observed density, absorbance data and mass spectrometry.|||Belongs to the encapsulin family. Family 1 subfamily.|||Encapsulin nanocompartment|||Foreign proteins can be targeted to ectopic nanocompartments in E.coli upon coexpression with a construct using the 15 C-terminal residues of Flp (AC Q9WZP3), tested with GFP. There are at most 20 GFP per compartment. Empty nanocompartments can be disassembled by extreme pH or by 7 M guanidine hydrochloride (GuHCl); only reassembly from GuHCl-dissociated compartments allows incorporation of targeted cargo (PubMed:27224728). The central pore in the pentamer can be enlarged by modifying the pore-forming loop (residues 184-189), which allows transport of larger metabolites than wild-type pores; both pore size and pore charge influence metabolite flux (PubMed:30376298, PubMed:35119930). Artificial metabolons made by targeting proteins to the outside and inside of the nanocompartment have been made in E.coli; increasing pore size increases metabolic flux (PubMed:33769792). Foreign proteins targeted to nanocompartments have been purified and characterized from insect cells. By C-terminally tagging only IDM1 of A.thaliana, all 6 components of the IDM complex were targeted to the nanocompartment (PubMed:32961724).|||Has 3 domains; a discontinuous peripheral domain (P, 13-39, 76-133, 221-254), an elongated loop (E, 53-73) and the discontinuous axial domain (A, 137-216 and 259-263). The E-loop forms contacts between two subunits, while the A domain mediates contacts in the 5-fold interface (PubMed:19172747). Pores are formed by residues 184-189, pore size can be modified by mutagenesis (PubMed:30376298, PubMed:33769792, PubMed:35119930).|||Homomultimeric (PubMed:9872409). This encapsulin nanocompartment is formed by 60 subunits; monomers form 12 pentamers which assemble to form shells. There are 12 pores where the pentamers meet as well as 3-fold axis channels and dimer channels; none are larger than 3-4 Angstroms in diameter. The N-terminus of the protein is inside the shell, the C-terminus is outside (PubMed:19172747, PubMed:30376298, PubMed:32961724, PubMed:33769792, PubMed:33953921, PubMed:34815415, PubMed:9872409, PubMed:35119930). Probably 3, 4 or 5 Flp cargo decamers bind inside the encapulin nanocompartment (PubMed:34815415) (Probable).|||Protease that exhibits activity toward chymotrypsin and trypsin substrates (PubMed:9872409, PubMed:11210524). Probably does not have antibacterial activity (Probable).|||Proteolysis activated by calcium and cobalt.|||Shell component of a type 1 encapsulin nanocompartment. Assembles into proteinaceous shells 23-24 nm in diameter with 2-2.5 nm thick walls. Cargo protein Flp (ferritin-like protein, probably stores iron) is targeted to the interior via its C-terminal extension; empty intact shells can be isolated in the absence of cargo protein (PubMed:19172747, PubMed:27224728, PubMed:32961724, PubMed:30376298, PubMed:33769792, PubMed:33953921, PubMed:34815415, PubMed:35119930). Fe(2+) may be able to pass though the 5-fold and dimer channels in the protein shell (PubMed:33953921) (Probable).|||Shows substantial structural similarity to gp5 of the HK97 viral capsid; while the sequence homology is weak, it suggests this protein may have evolved from a viral capsid protein. http://togogenome.org/gene/243274:THEMA_RS06735 ^@ http://purl.uniprot.org/uniprot/G4FFN4|||http://purl.uniprot.org/uniprot/P38510 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/243274:THEMA_RS06780 ^@ http://purl.uniprot.org/uniprot/G4FFM5|||http://purl.uniprot.org/uniprot/P38517 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/243274:THEMA_RS00580 ^@ http://purl.uniprot.org/uniprot/Q9WZS1|||http://purl.uniprot.org/uniprot/R4NPS6 ^@ Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/243274:THEMA_RS02385 ^@ http://purl.uniprot.org/uniprot/Q9ZHG4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DNA polymerase type-C family. DnaE subfamily.|||Cytoplasm|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the PolIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex (By similarity).|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity). http://togogenome.org/gene/243274:THEMA_RS05490 ^@ http://purl.uniprot.org/uniprot/Q9X258|||http://purl.uniprot.org/uniprot/R4P450 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. http://togogenome.org/gene/243274:THEMA_RS04375 ^@ http://purl.uniprot.org/uniprot/Q9WXT2 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activity stimulated by up to 40% in the presence of divalent cations such as BaCl(2), CaCl(2), MgCl(2) and MnCl(2) at 3 mM concentration, but inhibited by 82-85% in the presence of CdCl(2) and ZnCl(2) at 3 mM concentration.|||Belongs to the carbohydrate esterase 7 family.|||Cytoplasm|||Esterase that removes acetyl groups from a number of O-acetylated small substrates, such as acetylated xylose, short xylo-oligosaccharides and cephalosporin C. Has no activity towards polymeric acetylated xylan, 4-methylumbelliferyl acetate or alpha-naphthyl acetate. Able to catalyze rapid hydrolysis of a range of substrates preferably with acetate groups, independent of the alcohol moiety. Exhibits a narrow selectivity for short chain acyl esters (C2-C3). Displays broad substrate specificity by hydrolyzing acetate at 2, 3, and 4 positions of 4-nitrophenyl-beta-D-xylopyranoside (pNP-Xyl) with similar efficiency. Cannot cleave amide linkages.|||Homohexamer, formed by a trimer of dimers. Also exists as a homodimer. http://togogenome.org/gene/243274:THEMA_RS07265 ^@ http://purl.uniprot.org/uniprot/G4FFD0|||http://purl.uniprot.org/uniprot/Q9X1B4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HSP33 family.|||Cytoplasm|||Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.|||Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive. http://togogenome.org/gene/243274:THEMA_RS00550 ^@ http://purl.uniprot.org/uniprot/Q9WZS6|||http://purl.uniprot.org/uniprot/R4NPT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/243274:THEMA_RS07500 ^@ http://purl.uniprot.org/uniprot/G4FF87|||http://purl.uniprot.org/uniprot/Q9X172 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/243274:THEMA_RS06495 ^@ http://purl.uniprot.org/uniprot/Q9X1M9|||http://purl.uniprot.org/uniprot/R4NRN0 ^@ Similarity ^@ Belongs to the flagella basal body rod proteins family. http://togogenome.org/gene/243274:THEMA_RS08220 ^@ http://purl.uniprot.org/uniprot/Q9X0T3|||http://purl.uniprot.org/uniprot/R4P0L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS03415 ^@ http://purl.uniprot.org/uniprot/G4FHH2|||http://purl.uniprot.org/uniprot/P46799 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Binds two Mg(2+) per subunit.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/243274:THEMA_RS04460 ^@ http://purl.uniprot.org/uniprot/Q9WXR6|||http://purl.uniprot.org/uniprot/R4NZF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS09340 ^@ http://purl.uniprot.org/uniprot/Q9X081 ^@ Similarity ^@ To E.coli YfaT and P.aeruginosa PA4490. http://togogenome.org/gene/243274:THEMA_RS04145 ^@ http://purl.uniprot.org/uniprot/Q9WXX7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 9 family.|||Part of an ATP-binding cassette (ABC) transport system involved in metal import (By similarity). Binds a metal with high affinity and specificity and delivers it to the membrane permease for translocation into the cytoplasm (By similarity).|||Periplasm http://togogenome.org/gene/243274:THEMA_RS06310 ^@ http://purl.uniprot.org/uniprot/G4FFW7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF2.|||Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. http://togogenome.org/gene/243274:THEMA_RS05965 ^@ http://purl.uniprot.org/uniprot/P96111 ^@ Similarity ^@ In the C-terminal section; belongs to the PyrI family.|||In the N-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. http://togogenome.org/gene/243274:THEMA_RS08990 ^@ http://purl.uniprot.org/uniprot/G4FEU2|||http://purl.uniprot.org/uniprot/Q9X0E6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CutA family.|||Cytoplasm|||Homotrimer.|||Involved in resistance toward heavy metals. http://togogenome.org/gene/243274:THEMA_RS02730 ^@ http://purl.uniprot.org/uniprot/Q9WYM8|||http://purl.uniprot.org/uniprot/R4NY27 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/243274:THEMA_RS06360 ^@ http://purl.uniprot.org/uniprot/Q9X1Q5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/243274:THEMA_RS04805 ^@ http://purl.uniprot.org/uniprot/G4FGQ7|||http://purl.uniprot.org/uniprot/Q9X2H9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endonuclease V family.|||Cytoplasm|||DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.|||DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. In vitro, can also cleave single-stranded substrates with inosine, double-stranded DNA with apurinic sites, or DNA sites with uracil or a mismatched base. When present in molar excess, two protein molecules can bind to the same DNA substrate and effect cleavage of both strands (in vitro). http://togogenome.org/gene/243274:THEMA_RS07165 ^@ http://purl.uniprot.org/uniprot/G4FFE9|||http://purl.uniprot.org/uniprot/O33833 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 32 family.|||Hydrolysis of sucrose, raffinose, inulin and levan. Specific for the fructose moiety and the beta-anomeric configuration of the glycosidic linkages of its substrates. The enzyme released fructose from sucrose and raffinose, and the fructose polymer inulin is hydrolyzed quantitatively in an exo-type fashion. http://togogenome.org/gene/243274:THEMA_RS02545 ^@ http://purl.uniprot.org/uniprot/Q9WYR4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the polysaccharide lyase 1 family.|||Cleaves unsaturated trigalacturonate from pectin. Activity is highest towards polygalacturonic acid, activity on methylated pectins decreases with an increasing degree of methylation.|||Completely inactivated by EGTA.|||Homotetramer.|||Secreted http://togogenome.org/gene/243274:THEMA_RS06785 ^@ http://purl.uniprot.org/uniprot/G4FFM4|||http://purl.uniprot.org/uniprot/Q9ZAE6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/243274:THEMA_RS06215 ^@ http://purl.uniprot.org/uniprot/Q9X1S9|||http://purl.uniprot.org/uniprot/R4NRT5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS01235 ^@ http://purl.uniprot.org/uniprot/Q9WZF2|||http://purl.uniprot.org/uniprot/R4NQX5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DnaX/STICHEL family.|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/243274:THEMA_RS02985 ^@ http://purl.uniprot.org/uniprot/Q9WYH8 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the class-I DAHP synthase family.|||Catalyzes the condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).|||Divalent metal ions.|||Homotetramer.|||Inhibited by L-phenylalanine and L-tyrosine. http://togogenome.org/gene/243274:THEMA_RS08755 ^@ http://purl.uniprot.org/uniprot/G4FEP6|||http://purl.uniprot.org/uniprot/Q9X0I6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribonuclease III family.|||Cytoplasm|||Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Probably processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.|||Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS06040 ^@ http://purl.uniprot.org/uniprot/G4FG16|||http://purl.uniprot.org/uniprot/Q9X1W2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/243274:THEMA_RS04830 ^@ http://purl.uniprot.org/uniprot/G4FGQ2|||http://purl.uniprot.org/uniprot/Q9X2H4 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/243274:THEMA_RS09100 ^@ http://purl.uniprot.org/uniprot/G4FEW4|||http://purl.uniprot.org/uniprot/Q9X0C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-N-acetylglucosamine 2-epimerase family.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS02825 ^@ http://purl.uniprot.org/uniprot/Q9WYK8 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PduL family.|||Cytoplasm|||Formed by 2 beta-barrels, each is capped on both ends by short alpha-helices.|||Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.|||There are 2 Zn(2+) ions per monomer; Zn(2+) and CoA bind inbetween the 2 domains in each monomer. http://togogenome.org/gene/243274:THEMA_RS02295 ^@ http://purl.uniprot.org/uniprot/G4FDZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Membrane http://togogenome.org/gene/243274:THEMA_RS08015 ^@ http://purl.uniprot.org/uniprot/Q9X0X5|||http://purl.uniprot.org/uniprot/R4P0S2 ^@ Caution|||Function|||Similarity ^@ Belongs to the GART family.|||Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS00005 ^@ http://purl.uniprot.org/uniprot/G4FF64|||http://purl.uniprot.org/uniprot/P46798 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/243274:THEMA_RS08945 ^@ http://purl.uniprot.org/uniprot/Q9X0F5|||http://purl.uniprot.org/uniprot/R4P271 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS06130 ^@ http://purl.uniprot.org/uniprot/G4FFZ8|||http://purl.uniprot.org/uniprot/O50550 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/243274:THEMA_RS08235 ^@ http://purl.uniprot.org/uniprot/Q9X0T0|||http://purl.uniprot.org/uniprot/R4P0A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.|||Cell membrane|||Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/243274:THEMA_RS02765 ^@ http://purl.uniprot.org/uniprot/Q9WYL9|||http://purl.uniprot.org/uniprot/R4NQ27 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS04550 ^@ http://purl.uniprot.org/uniprot/Q9WXP9|||http://purl.uniprot.org/uniprot/R4NMK1 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/243274:THEMA_RS01060 ^@ http://purl.uniprot.org/uniprot/G4FDA3|||http://purl.uniprot.org/uniprot/Q9WZH9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS05345 ^@ http://purl.uniprot.org/uniprot/G4FGF0|||http://purl.uniprot.org/uniprot/Q9X284 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/243274:THEMA_RS02120 ^@ http://purl.uniprot.org/uniprot/Q9WYY2|||http://purl.uniprot.org/uniprot/R4P0N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FliJ family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS00920 ^@ http://purl.uniprot.org/uniprot/Q9WZK6|||http://purl.uniprot.org/uniprot/R4P1E3 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/243274:THEMA_RS06765 ^@ http://purl.uniprot.org/uniprot/G4FFM8|||http://purl.uniprot.org/uniprot/P38519 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/243274:THEMA_RS06725 ^@ http://purl.uniprot.org/uniprot/G4FFN6|||http://purl.uniprot.org/uniprot/P38516 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ A protein containing 11 mutations, chosen as amino acids which probably interact with nucleic acids (K140A, E141Q, Q144K, Q147A, S149E, K151delta, K152delta, I155M, P158G, W159E and K160L), gained the ability to regulate the E.coli S10 operon, suggesting it is now able to mediate contacts of L4 with the S10 mRNA leader in E.coli. This mutant protein did not associate any better with E.coli ribosomes however, indicating a separation of residues interacting with rRNA and mRNA.|||Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit.|||The structure indicates that the N-terminal domain may bind to the 23S rRNA, while the C-terminal domain may bind to the mRNA, which could then be implicated in transcriptional and translational control of the S10 operon. However, it is not known if the S10 operon is controlled in this fashion in this organism.|||This protein only weakly controls expression of the E.coli S10 operon. It is incorporated into E.coli ribosomes, however it is not as firmly associated as the endogenous protein. http://togogenome.org/gene/243274:THEMA_RS02565 ^@ http://purl.uniprot.org/uniprot/Q9WYR0|||http://purl.uniprot.org/uniprot/R4NQ60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family.|||Cell membrane|||Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. http://togogenome.org/gene/243274:THEMA_RS01960 ^@ http://purl.uniprot.org/uniprot/Q9WZ13|||http://purl.uniprot.org/uniprot/R4NNY7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS09125 ^@ http://purl.uniprot.org/uniprot/Q9X0B9|||http://purl.uniprot.org/uniprot/R4P023 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS04110 ^@ http://purl.uniprot.org/uniprot/Q9WXY4|||http://purl.uniprot.org/uniprot/R4NXB7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS08885 ^@ http://purl.uniprot.org/uniprot/G4FES1|||http://purl.uniprot.org/uniprot/Q9X0G6 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pantothenate synthetase family.|||Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.|||Cytoplasm|||Homodimer.|||The reaction proceeds by a bi uni uni bi ping pong mechanism. http://togogenome.org/gene/243274:THEMA_RS01750 ^@ http://purl.uniprot.org/uniprot/Q9WZ52|||http://purl.uniprot.org/uniprot/R4NQL4 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/243274:THEMA_RS04135 ^@ http://purl.uniprot.org/uniprot/G4FH40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS08190 ^@ http://purl.uniprot.org/uniprot/Q9X0T9|||http://purl.uniprot.org/uniprot/R4P2M8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS05605 ^@ http://purl.uniprot.org/uniprot/Q9X238|||http://purl.uniprot.org/uniprot/R4NS63 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/243274:THEMA_RS01440 ^@ http://purl.uniprot.org/uniprot/G4FDH9|||http://purl.uniprot.org/uniprot/Q9WZB3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS05335 ^@ http://purl.uniprot.org/uniprot/G4FGF2|||http://purl.uniprot.org/uniprot/Q9X286 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NusB family.|||Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.|||Monomer or homodimer; in equilibrium, with a preference for the monomer. Dimerization may be employed to package NusB in an inactive form until recruitment into antitermination complexes. http://togogenome.org/gene/243274:THEMA_RS07710 ^@ http://purl.uniprot.org/uniprot/Q9X136|||http://purl.uniprot.org/uniprot/R4NR32 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS02165 ^@ http://purl.uniprot.org/uniprot/Q9WYX2|||http://purl.uniprot.org/uniprot/R4NYC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS04220 ^@ http://purl.uniprot.org/uniprot/G4FH23|||http://purl.uniprot.org/uniprot/Q9WXW3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS05270 ^@ http://purl.uniprot.org/uniprot/G4FGG5|||http://purl.uniprot.org/uniprot/Q9X299 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RimP family.|||Cytoplasm|||Required for maturation of 30S ribosomal subunits. http://togogenome.org/gene/243274:THEMA_RS03545 ^@ http://purl.uniprot.org/uniprot/G4FHE6|||http://purl.uniprot.org/uniprot/Q9WY74 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family. MurG subfamily.|||Cell inner membrane|||Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS05395 ^@ http://purl.uniprot.org/uniprot/G4FGE1 ^@ Similarity ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family. http://togogenome.org/gene/243274:THEMA_RS05725 ^@ http://purl.uniprot.org/uniprot/G4FG76|||http://purl.uniprot.org/uniprot/Q9X215 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/243274:THEMA_RS09570 ^@ http://purl.uniprot.org/uniprot/Q9X038|||http://purl.uniprot.org/uniprot/R4NZU0 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/243274:THEMA_RS06645 ^@ http://purl.uniprot.org/uniprot/Q9X1K3|||http://purl.uniprot.org/uniprot/R4P1D6 ^@ Cofactor|||Similarity ^@ Belongs to the Fur family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/243274:THEMA_RS02835 ^@ http://purl.uniprot.org/uniprot/G4FHT5|||http://purl.uniprot.org/uniprot/Q9WYK6 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock (By similarity).|||By stress conditions e.g. heat shock. http://togogenome.org/gene/243274:THEMA_RS04250 ^@ http://purl.uniprot.org/uniprot/Q9WXV7|||http://purl.uniprot.org/uniprot/R4NMQ7 ^@ Similarity ^@ Belongs to the BMP lipoprotein family. http://togogenome.org/gene/243274:THEMA_RS03530 ^@ http://purl.uniprot.org/uniprot/G4FHE9|||http://purl.uniprot.org/uniprot/Q9WY77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell inner membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS05705 ^@ http://purl.uniprot.org/uniprot/Q9X219|||http://purl.uniprot.org/uniprot/R4NS39 ^@ Domain|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/243274:THEMA_RS09045 ^@ http://purl.uniprot.org/uniprot/Q9X0D5|||http://purl.uniprot.org/uniprot/R4P251 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CitM (TC 2.A.11) transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS00375 ^@ http://purl.uniprot.org/uniprot/Q9WZV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUA5 family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/243274:THEMA_RS01190 ^@ http://purl.uniprot.org/uniprot/G4FDC9|||http://purl.uniprot.org/uniprot/Q9WZF9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/243274:THEMA_RS00010 ^@ http://purl.uniprot.org/uniprot/G4FF65|||http://purl.uniprot.org/uniprot/Q9X027 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS04210 ^@ http://purl.uniprot.org/uniprot/Q9WXW5|||http://purl.uniprot.org/uniprot/R4NZK7 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/243274:THEMA_RS09140 ^@ http://purl.uniprot.org/uniprot/Q9X0B6|||http://purl.uniprot.org/uniprot/R4NZT4 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/243274:THEMA_RS08000 ^@ http://purl.uniprot.org/uniprot/Q9X0X8|||http://purl.uniprot.org/uniprot/R4NQZ4 ^@ Similarity ^@ Belongs to the AIR synthase family. http://togogenome.org/gene/243274:THEMA_RS08515 ^@ http://purl.uniprot.org/uniprot/Q9X0N3|||http://purl.uniprot.org/uniprot/R4NQM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS02440 ^@ http://purl.uniprot.org/uniprot/G4FE19|||http://purl.uniprot.org/uniprot/P35873 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/243274:THEMA_RS03390 ^@ http://purl.uniprot.org/uniprot/G4FHH7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/243274:THEMA_RS04565 ^@ http://purl.uniprot.org/uniprot/G4FGV6|||http://purl.uniprot.org/uniprot/Q9WXP6 ^@ Function|||Similarity ^@ Belongs to the GTP cyclohydrolase IV family.|||Converts GTP to 7,8-dihydroneopterin triphosphate. http://togogenome.org/gene/243274:THEMA_RS08720 ^@ http://purl.uniprot.org/uniprot/G4FEN9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS06080 ^@ http://purl.uniprot.org/uniprot/Q9X1V4|||http://purl.uniprot.org/uniprot/R4P1N5 ^@ Function|||Similarity ^@ Belongs to the DNA polymerase type-A family.|||In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. http://togogenome.org/gene/243274:THEMA_RS02080 ^@ http://purl.uniprot.org/uniprot/G4FDV1|||http://purl.uniprot.org/uniprot/Q9WYZ0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS05545 ^@ http://purl.uniprot.org/uniprot/R4P234 ^@ Similarity ^@ Belongs to the V-ATPase D subunit family. http://togogenome.org/gene/243274:THEMA_RS08800 ^@ http://purl.uniprot.org/uniprot/G4FEQ4|||http://purl.uniprot.org/uniprot/Q9X0H8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/243274:THEMA_RS05240 ^@ http://purl.uniprot.org/uniprot/G4FGH1|||http://purl.uniprot.org/uniprot/Q9X2A4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically inhibited by arginine.|||Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/243274:THEMA_RS01105 ^@ http://purl.uniprot.org/uniprot/Q9WZH1|||http://purl.uniprot.org/uniprot/R4NZ85 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS01090 ^@ http://purl.uniprot.org/uniprot/Q9WZH4|||http://purl.uniprot.org/uniprot/R4NPI1 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/243274:THEMA_RS01905 ^@ http://purl.uniprot.org/uniprot/G4FDR7|||http://purl.uniprot.org/uniprot/Q9WZ24 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/243274:THEMA_RS05470 ^@ http://purl.uniprot.org/uniprot/Q9X262|||http://purl.uniprot.org/uniprot/R4P247 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MrnC RNase family.|||Cytoplasm|||Homodimer.|||Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors. http://togogenome.org/gene/243274:THEMA_RS08845 ^@ http://purl.uniprot.org/uniprot/G4FER3|||http://purl.uniprot.org/uniprot/O33925 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS00615 ^@ http://purl.uniprot.org/uniprot/G4FD17|||http://purl.uniprot.org/uniprot/Q9WZR4 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/243274:THEMA_RS04755 ^@ http://purl.uniprot.org/uniprot/G4FGR7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/243274:THEMA_RS05755 ^@ http://purl.uniprot.org/uniprot/G4FG70|||http://purl.uniprot.org/uniprot/O54310 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Monomer. http://togogenome.org/gene/243274:THEMA_RS06400 ^@ http://purl.uniprot.org/uniprot/Q9X1P7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).|||Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1. http://togogenome.org/gene/243274:THEMA_RS01445 ^@ http://purl.uniprot.org/uniprot/Q9WZB2|||http://purl.uniprot.org/uniprot/R4NYR6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS04580 ^@ http://purl.uniprot.org/uniprot/G4FGV3|||http://purl.uniprot.org/uniprot/Q9WXP3 ^@ Function|||Similarity ^@ Belongs to the THEP1 NTPase family.|||Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency. http://togogenome.org/gene/243274:THEMA_RS00590 ^@ http://purl.uniprot.org/uniprot/Q9WZR9|||http://purl.uniprot.org/uniprot/R4P1I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS08445 ^@ http://purl.uniprot.org/uniprot/G4FEI4|||http://purl.uniprot.org/uniprot/Q9X0P5 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/243274:THEMA_RS07360 ^@ http://purl.uniprot.org/uniprot/Q9X197|||http://purl.uniprot.org/uniprot/R4P312 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS06165 ^@ http://purl.uniprot.org/uniprot/Q9X1T9|||http://purl.uniprot.org/uniprot/R4NRU6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS06425 ^@ http://purl.uniprot.org/uniprot/Q9X1P2|||http://purl.uniprot.org/uniprot/R4P3I2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family. YhdE subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/243274:THEMA_RS00100 ^@ http://purl.uniprot.org/uniprot/Q9X009|||http://purl.uniprot.org/uniprot/R4NZI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family.|||Cell membrane|||Membrane|||Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum. http://togogenome.org/gene/243274:THEMA_RS08625 ^@ http://purl.uniprot.org/uniprot/G4FEM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferritin family. Prokaryotic subfamily.|||Cytoplasm|||Iron-storage protein. http://togogenome.org/gene/243274:THEMA_RS03970 ^@ http://purl.uniprot.org/uniprot/G4FH72|||http://purl.uniprot.org/uniprot/Q9WY05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell inner membrane http://togogenome.org/gene/243274:THEMA_RS07990 ^@ http://purl.uniprot.org/uniprot/G4FE95|||http://purl.uniprot.org/uniprot/Q9X0Y0 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.|||In the C-terminal section; belongs to the NAD synthetase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS08980 ^@ http://purl.uniprot.org/uniprot/G4FEU0 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/243274:THEMA_RS06950 ^@ http://purl.uniprot.org/uniprot/G4FFJ1|||http://purl.uniprot.org/uniprot/Q9X1G7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/243274:THEMA_RS01010 ^@ http://purl.uniprot.org/uniprot/G4FD94 ^@ Function|||Similarity ^@ Belongs to the relA/spoT family.|||In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. http://togogenome.org/gene/243274:THEMA_RS01845 ^@ http://purl.uniprot.org/uniprot/G4FDQ5|||http://purl.uniprot.org/uniprot/Q9WZ35 ^@ Similarity ^@ Belongs to the SfsA family. http://togogenome.org/gene/243274:THEMA_RS08425 ^@ http://purl.uniprot.org/uniprot/Q9X0P9|||http://purl.uniprot.org/uniprot/R4P0G2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||Cytoplasm|||Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/243274:THEMA_RS02655 ^@ http://purl.uniprot.org/uniprot/Q9WYP2|||http://purl.uniprot.org/uniprot/R4P0D8 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/243274:THEMA_RS07130 ^@ http://purl.uniprot.org/uniprot/Q9X1D6|||http://purl.uniprot.org/uniprot/R4NRB5 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/243274:THEMA_RS01145 ^@ http://purl.uniprot.org/uniprot/G4FDC0|||http://purl.uniprot.org/uniprot/Q56308 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.|||Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.|||Cytoplasm|||Monomer. http://togogenome.org/gene/243274:THEMA_RS05595 ^@ http://purl.uniprot.org/uniprot/G4FGA2|||http://purl.uniprot.org/uniprot/Q9X240 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RlmN family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.|||Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. http://togogenome.org/gene/243274:THEMA_RS04980 ^@ http://purl.uniprot.org/uniprot/Q9X2F5|||http://purl.uniprot.org/uniprot/R4P224 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS09195 ^@ http://purl.uniprot.org/uniprot/G4FEY2|||http://purl.uniprot.org/uniprot/P96110 ^@ Similarity|||Subunit ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Homohexamer. http://togogenome.org/gene/243274:THEMA_RS03140 ^@ http://purl.uniprot.org/uniprot/Q9WYE9|||http://purl.uniprot.org/uniprot/R4NY76 ^@ Similarity ^@ Belongs to the shaker potassium channel beta subunit family. http://togogenome.org/gene/243274:THEMA_RS04825 ^@ http://purl.uniprot.org/uniprot/G4FGQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/243274:THEMA_RS06500 ^@ http://purl.uniprot.org/uniprot/Q9X1M8|||http://purl.uniprot.org/uniprot/R4P176 ^@ Similarity|||Subunit ^@ Belongs to the flagella basal body rod proteins family.|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each. http://togogenome.org/gene/243274:THEMA_RS00455 ^@ http://purl.uniprot.org/uniprot/Q9WZU1|||http://purl.uniprot.org/uniprot/R4NZB9 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/243274:THEMA_RS06865 ^@ http://purl.uniprot.org/uniprot/G4FFK8|||http://purl.uniprot.org/uniprot/Q9X1I1 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/243274:THEMA_RS06960 ^@ http://purl.uniprot.org/uniprot/G4FFI9|||http://purl.uniprot.org/uniprot/Q9X1G5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/243274:THEMA_RS07425 ^@ http://purl.uniprot.org/uniprot/G4FFA2|||http://purl.uniprot.org/uniprot/Q9X186 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliE family. http://togogenome.org/gene/243274:THEMA_RS06755 ^@ http://purl.uniprot.org/uniprot/G4FFN0|||http://purl.uniprot.org/uniprot/P38509 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/243274:THEMA_RS03660 ^@ http://purl.uniprot.org/uniprot/G4FHC3|||http://purl.uniprot.org/uniprot/Q9WY52 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.|||Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate. Strongly inhibited by diphosphate, triphosphate and polyphosphate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mg(2+). Mg(2+) can partially be replaced by Mn(2+) and Fe(2+). http://togogenome.org/gene/243274:THEMA_RS00645 ^@ http://purl.uniprot.org/uniprot/G4FD23|||http://purl.uniprot.org/uniprot/Q9WZQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thioester dehydratase family. FabZ subfamily.|||Cytoplasm|||Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. http://togogenome.org/gene/243274:THEMA_RS00875 ^@ http://purl.uniprot.org/uniprot/Q9WZL4|||http://purl.uniprot.org/uniprot/R4NR63 ^@ Similarity ^@ In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family. http://togogenome.org/gene/243274:THEMA_RS00465 ^@ http://purl.uniprot.org/uniprot/Q9WZU0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.|||Cell inner membrane|||Self-interacts. Interacts with FtsZ. http://togogenome.org/gene/243274:THEMA_RS00575 ^@ http://purl.uniprot.org/uniprot/Q9WZS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Cell membrane|||Multidrug efflux pump. http://togogenome.org/gene/243274:THEMA_RS01645 ^@ http://purl.uniprot.org/uniprot/G4FDL6|||http://purl.uniprot.org/uniprot/Q9WZ72 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with bS18 to 16S ribosomal RNA. http://togogenome.org/gene/243274:THEMA_RS02960 ^@ http://purl.uniprot.org/uniprot/G4FHR0|||http://purl.uniprot.org/uniprot/Q9WYI3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||In the C-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.|||In the N-terminal section; belongs to the shikimate kinase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/243274:THEMA_RS00160 ^@ http://purl.uniprot.org/uniprot/G4FCT0|||http://purl.uniprot.org/uniprot/Q9WZZ7 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.|||Synthesizes alpha-1,4-glucan chains using ADP-glucose. http://togogenome.org/gene/243274:THEMA_RS07045 ^@ http://purl.uniprot.org/uniprot/G4FFH2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/243274:THEMA_RS05045 ^@ http://purl.uniprot.org/uniprot/Q9X2E2|||http://purl.uniprot.org/uniprot/R4NU47 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. HflK subfamily.|||HflC and HflK could encode or regulate a protease.|||HflC and HflK may interact to form a multimeric complex.|||Membrane http://togogenome.org/gene/243274:THEMA_RS03155 ^@ http://purl.uniprot.org/uniprot/Q9WYE6|||http://purl.uniprot.org/uniprot/R4NXW2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 42 family. http://togogenome.org/gene/243274:THEMA_RS03035 ^@ http://purl.uniprot.org/uniprot/G4FHP6|||http://purl.uniprot.org/uniprot/Q9WYG8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.|||Catalyzes the conversion of dihydroorotate to orotate.|||Cytoplasm|||Heterotetramer of 2 PyrK and 2 PyrD type B subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS00950 ^@ http://purl.uniprot.org/uniprot/G4FD82|||http://purl.uniprot.org/uniprot/Q9WZK0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/243274:THEMA_RS07510 ^@ http://purl.uniprot.org/uniprot/G4FF85|||http://purl.uniprot.org/uniprot/Q9X170 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS05005 ^@ http://purl.uniprot.org/uniprot/Q9X2F1|||http://purl.uniprot.org/uniprot/R4P220 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/243274:THEMA_RS00230 ^@ http://purl.uniprot.org/uniprot/G4FCU4|||http://purl.uniprot.org/uniprot/Q9WZY3 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MetA family.|||Cytoplasm|||Inhibited by iodoacetamide in a pH-dependent manner.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.|||Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine. Has weak activity with succinyl-CoA as the acyl donor. http://togogenome.org/gene/243274:THEMA_RS01855 ^@ http://purl.uniprot.org/uniprot/Q9WZ33|||http://purl.uniprot.org/uniprot/R4NQI8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS05625 ^@ http://purl.uniprot.org/uniprot/G4FG96|||http://purl.uniprot.org/uniprot/Q9X235 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gluconeogenesis factor family.|||Cytoplasm|||Required for morphogenesis under gluconeogenic growth conditions. http://togogenome.org/gene/243274:THEMA_RS06160 ^@ http://purl.uniprot.org/uniprot/G4FFZ2|||http://purl.uniprot.org/uniprot/Q9X1U0 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by GTP. Inhibited by UTP.|||Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS07125 ^@ http://purl.uniprot.org/uniprot/Q9X1D7 ^@ Cofactor|||Function ^@ Binds 1 [2Fe-2S] cluster.|||Might be part of a multi-protein complex, possibly involved in metal cluster assembly. http://togogenome.org/gene/243274:THEMA_RS05715 ^@ http://purl.uniprot.org/uniprot/Q9X217|||http://purl.uniprot.org/uniprot/R4P3Y4 ^@ Similarity ^@ Belongs to the YicC/YloC family. http://togogenome.org/gene/243274:THEMA_RS05950 ^@ http://purl.uniprot.org/uniprot/Q9X1X8|||http://purl.uniprot.org/uniprot/R4P3T6 ^@ Function|||Similarity ^@ Belongs to the NadC/ModD family.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/243274:THEMA_RS07880 ^@ http://purl.uniprot.org/uniprot/Q9X102|||http://purl.uniprot.org/uniprot/R4P0J7 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/243274:THEMA_RS07655 ^@ http://purl.uniprot.org/uniprot/Q9X145 ^@ Similarity ^@ Belongs to the UPF0150 family. http://togogenome.org/gene/243274:THEMA_RS01430 ^@ http://purl.uniprot.org/uniprot/G4FDH7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IspF family.|||Binds 1 divalent metal cation per subunit.|||Homotrimer.|||Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS05340 ^@ http://purl.uniprot.org/uniprot/Q9X285|||http://purl.uniprot.org/uniprot/R4P266 ^@ Similarity ^@ Belongs to the asp23 family. http://togogenome.org/gene/243274:THEMA_RS03395 ^@ http://purl.uniprot.org/uniprot/Q9WYA0|||http://purl.uniprot.org/uniprot/R4NPR8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA. http://togogenome.org/gene/243274:THEMA_RS00805 ^@ http://purl.uniprot.org/uniprot/Q9WZM7|||http://purl.uniprot.org/uniprot/R4NPP0 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/243274:THEMA_RS05640 ^@ http://purl.uniprot.org/uniprot/G4FG93|||http://purl.uniprot.org/uniprot/Q9X232 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/243274:THEMA_RS06120 ^@ http://purl.uniprot.org/uniprot/G4FG00|||http://purl.uniprot.org/uniprot/Q9X1U7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/243274:THEMA_RS03335 ^@ http://purl.uniprot.org/uniprot/G4FHI8|||http://purl.uniprot.org/uniprot/Q9WYB1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Phosphorylates propionate (54%) in addition to acetate (100%). Uses GTP (100%), ITP (163%), UTP (56%), and CTP (21%) as phosphoryl donors in addition to ATP (100%).|||Cytoplasm|||Homodimer.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/243274:THEMA_RS03375 ^@ http://purl.uniprot.org/uniprot/G4FHI0 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/243274:THEMA_RS03435 ^@ http://purl.uniprot.org/uniprot/P56944 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/243274:THEMA_RS06135 ^@ http://purl.uniprot.org/uniprot/G4FFZ7|||http://purl.uniprot.org/uniprot/Q9X1U5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/243274:THEMA_RS02365 ^@ http://purl.uniprot.org/uniprot/G4FE04|||http://purl.uniprot.org/uniprot/Q9WYT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS06110 ^@ http://purl.uniprot.org/uniprot/G4FG02|||http://purl.uniprot.org/uniprot/Q9X1U9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell inner membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Membrane http://togogenome.org/gene/243274:THEMA_RS02625 ^@ http://purl.uniprot.org/uniprot/Q9WYP8|||http://purl.uniprot.org/uniprot/R4NY47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.|||Membrane http://togogenome.org/gene/243274:THEMA_RS07820 ^@ http://purl.uniprot.org/uniprot/G4FE63|||http://purl.uniprot.org/uniprot/Q9X112 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the vitamin-B12 independent methionine synthase family.|||Binds 1 zinc ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation. http://togogenome.org/gene/243274:THEMA_RS08035 ^@ http://purl.uniprot.org/uniprot/Q9X0X1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PurS family.|||Cytoplasm|||Homodimer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/243274:THEMA_RS07325 ^@ http://purl.uniprot.org/uniprot/G4FFC0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS00085 ^@ http://purl.uniprot.org/uniprot/Q9X012 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliR/MopE/SpaR family.|||Cell membrane|||Membrane|||Role in flagellar biosynthesis. http://togogenome.org/gene/243274:THEMA_RS08835 ^@ http://purl.uniprot.org/uniprot/Q9X0H3|||http://purl.uniprot.org/uniprot/R4NQG5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS02150 ^@ http://purl.uniprot.org/uniprot/G4FDW5|||http://purl.uniprot.org/uniprot/Q9WYX6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/243274:THEMA_RS08530 ^@ http://purl.uniprot.org/uniprot/G4FEK1|||http://purl.uniprot.org/uniprot/Q9X0N0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family.|||Cell membrane|||Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. http://togogenome.org/gene/243274:THEMA_RS08030 ^@ http://purl.uniprot.org/uniprot/G4FEA3|||http://purl.uniprot.org/uniprot/Q9X0X2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/243274:THEMA_RS07235 ^@ http://purl.uniprot.org/uniprot/Q9X1C0 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.|||Involved in the degradation of L-serine via 3-hydroxypyruvate. Catalyzes the transamination between L-serine and pyruvate to yield 3-hydroxypyruvate and alanine. http://togogenome.org/gene/243274:THEMA_RS01970 ^@ http://purl.uniprot.org/uniprot/Q9WZ11|||http://purl.uniprot.org/uniprot/R4P0Q9 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/243274:THEMA_RS00690 ^@ http://purl.uniprot.org/uniprot/Q9WZP9|||http://purl.uniprot.org/uniprot/R4P1G9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.|||Cell inner membrane|||Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. http://togogenome.org/gene/243274:THEMA_RS02990 ^@ http://purl.uniprot.org/uniprot/Q9WYH7|||http://purl.uniprot.org/uniprot/R4NNE2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS05515 ^@ http://purl.uniprot.org/uniprot/Q9X253|||http://purl.uniprot.org/uniprot/R4P448 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. http://togogenome.org/gene/243274:THEMA_RS02425 ^@ http://purl.uniprot.org/uniprot/G4FE17|||http://purl.uniprot.org/uniprot/P29397 ^@ Activity Regulation|||Domain|||Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination.|||Regulated by autoinhibition via interaction of the N-terminal and the C-terminal domains. Autoinhibition may prevent NusG from interacting prematurely with other components of the transcription complex or non-specific interactions with other cellular components.|||The N-terminal domain interacts with RNAP and the C-terminal domain binds either to Rho or to RpsJ (NusE). Contains an additional, species-specific domain inserted into the N-terminal domain. The N-terminal and C-terminal domains can interact and form a closed conformation. http://togogenome.org/gene/243274:THEMA_RS04440 ^@ http://purl.uniprot.org/uniprot/G4FGX9|||http://purl.uniprot.org/uniprot/Q9WXR9 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.|||Homotrimer. http://togogenome.org/gene/243274:THEMA_RS07140 ^@ http://purl.uniprot.org/uniprot/G4FFF3 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/243274:THEMA_RS08520 ^@ http://purl.uniprot.org/uniprot/Q9X0N2|||http://purl.uniprot.org/uniprot/R4P046 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/243274:THEMA_RS03080 ^@ http://purl.uniprot.org/uniprot/Q9WYG0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/243274:THEMA_RS06835 ^@ http://purl.uniprot.org/uniprot/G4FFL4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/243274:THEMA_RS01925 ^@ http://purl.uniprot.org/uniprot/G4FDS1|||http://purl.uniprot.org/uniprot/Q9WZ20 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS08770 ^@ http://purl.uniprot.org/uniprot/G4FEP9|||http://purl.uniprot.org/uniprot/Q9X0I3 ^@ Function|||Similarity ^@ Belongs to the thymidylate kinase family.|||Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. http://togogenome.org/gene/243274:THEMA_RS08490 ^@ http://purl.uniprot.org/uniprot/Q9X0N8|||http://purl.uniprot.org/uniprot/R4NQM8 ^@ Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.|||Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. http://togogenome.org/gene/243274:THEMA_RS07025 ^@ http://purl.uniprot.org/uniprot/G4FFH6|||http://purl.uniprot.org/uniprot/Q9X1F4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS08940 ^@ http://purl.uniprot.org/uniprot/Q9X0F6|||http://purl.uniprot.org/uniprot/R4NZW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS09035 ^@ http://purl.uniprot.org/uniprot/Q9X0D7|||http://purl.uniprot.org/uniprot/R4NQC6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MinC family.|||Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity).|||Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.|||Interacts with MinD and FtsZ. http://togogenome.org/gene/243274:THEMA_RS01790 ^@ http://purl.uniprot.org/uniprot/G4FDP4|||http://purl.uniprot.org/uniprot/Q9ZHF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-C family. PolC subfamily.|||Cytoplasm|||Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/243274:THEMA_RS06750 ^@ http://purl.uniprot.org/uniprot/P46772|||http://purl.uniprot.org/uniprot/R4NT51 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/243274:THEMA_RS07450 ^@ http://purl.uniprot.org/uniprot/G4FF97|||http://purl.uniprot.org/uniprot/P46213 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/243274:THEMA_RS06420 ^@ http://purl.uniprot.org/uniprot/Q9X1P3 ^@ Similarity ^@ Belongs to the UPF0758 family. http://togogenome.org/gene/243274:THEMA_RS00535 ^@ http://purl.uniprot.org/uniprot/G4FD03|||http://purl.uniprot.org/uniprot/Q9WZS8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/243274:THEMA_RS07085 ^@ http://purl.uniprot.org/uniprot/G4FFG4|||http://purl.uniprot.org/uniprot/Q9X1E3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).|||Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism.|||Membrane http://togogenome.org/gene/243274:THEMA_RS05460 ^@ http://purl.uniprot.org/uniprot/Q9X264|||http://purl.uniprot.org/uniprot/R4P1V1 ^@ Cofactor|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||Divalent metal ions. Mg(2+) is the most effective. http://togogenome.org/gene/243274:THEMA_RS09080 ^@ http://purl.uniprot.org/uniprot/G4FEW0|||http://purl.uniprot.org/uniprot/Q9X0C8 ^@ Activity Regulation|||Function|||Subcellular Location Annotation|||Subunit ^@ Activated by the binding of either IGP or PRFAR to the active site of HisF.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/243274:THEMA_RS02495 ^@ http://purl.uniprot.org/uniprot/Q9WYS4 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/243274:THEMA_RS06365 ^@ http://purl.uniprot.org/uniprot/G4FFV6|||http://purl.uniprot.org/uniprot/Q9X1Q4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.|||Belongs to the RimM family.|||Binds ribosomal protein uS19.|||Cytoplasm|||The PRC barrel domain binds ribosomal protein uS19. http://togogenome.org/gene/243274:THEMA_RS03570 ^@ http://purl.uniprot.org/uniprot/G4FHE1 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/243274:THEMA_RS09550 ^@ http://purl.uniprot.org/uniprot/G4FF47|||http://purl.uniprot.org/uniprot/P36205 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutamine synthetase family.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. Under conditions of nitrogen excess, feedback-inhibited GlnA forms a stable complex with TnrA, which inhibits its DNA-binding activity. In contrast, feedback-inhibited GlnA acts as a chaperone to stabilize the DNA-binding activity of GlnR, which represses the transcription of nitrogen assimilation genes.|||Inhibited by glutamine.|||Oligomer of 12 subunits arranged in the form of two hexagons. In its feedback-inhibited form, interacts with TnrA in order to block its DNA-binding activity. http://togogenome.org/gene/243274:THEMA_RS06810 ^@ http://purl.uniprot.org/uniprot/G4FFL9|||http://purl.uniprot.org/uniprot/Q9X1J1 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/243274:THEMA_RS00665 ^@ http://purl.uniprot.org/uniprot/G4FD27|||http://purl.uniprot.org/uniprot/Q9WZQ4 ^@ Similarity ^@ Belongs to the ComB family. http://togogenome.org/gene/243274:THEMA_RS04455 ^@ http://purl.uniprot.org/uniprot/G4FGX6|||http://purl.uniprot.org/uniprot/Q60037 ^@ Domain|||Similarity ^@ Belongs to the glycosyl hydrolase 10 (cellulase F) family.|||The C-terminal CBM-CenC domains mediate the binding of XynA to microcrystalline cellulose. CBM-CenC 2 alone can also promote cellulose binding. http://togogenome.org/gene/243274:THEMA_RS03560 ^@ http://purl.uniprot.org/uniprot/Q9WY71|||http://purl.uniprot.org/uniprot/R4NZY6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS04365 ^@ http://purl.uniprot.org/uniprot/Q9WXT4|||http://purl.uniprot.org/uniprot/R4NXH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/243274:THEMA_RS00500 ^@ http://purl.uniprot.org/uniprot/Q9WZT5|||http://purl.uniprot.org/uniprot/R4NPU0 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/243274:THEMA_RS01395 ^@ http://purl.uniprot.org/uniprot/G4FDH0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.|||Homodimer or homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS01195 ^@ http://purl.uniprot.org/uniprot/G4FDD0|||http://purl.uniprot.org/uniprot/Q9WZF8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity).|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/243274:THEMA_RS00620 ^@ http://purl.uniprot.org/uniprot/Q9WZR3|||http://purl.uniprot.org/uniprot/R4NZI9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS06825 ^@ http://purl.uniprot.org/uniprot/Q9X1I8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.|||Cytoplasm|||Monomer. http://togogenome.org/gene/243274:THEMA_RS02645 ^@ http://purl.uniprot.org/uniprot/G4FHX2 ^@ Similarity ^@ Belongs to the creatininase superfamily. http://togogenome.org/gene/243274:THEMA_RS03715 ^@ http://purl.uniprot.org/uniprot/Q9WY41|||http://purl.uniprot.org/uniprot/R4NXU9 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/243274:THEMA_RS06895 ^@ http://purl.uniprot.org/uniprot/G4FFK2|||http://purl.uniprot.org/uniprot/Q9X1H7 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/243274:THEMA_RS05495 ^@ http://purl.uniprot.org/uniprot/G4FGC1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS08040 ^@ http://purl.uniprot.org/uniprot/G4FEA5|||http://purl.uniprot.org/uniprot/Q9X0X0 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/243274:THEMA_RS02670 ^@ http://purl.uniprot.org/uniprot/G4FHW7|||http://purl.uniprot.org/uniprot/Q9WYN9 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CheB family.|||Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.|||Cytoplasm|||Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.|||Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity. http://togogenome.org/gene/243274:THEMA_RS03565 ^@ http://purl.uniprot.org/uniprot/Q9WY70|||http://purl.uniprot.org/uniprot/R4NY04 ^@ Similarity ^@ Belongs to the complex I 51 kDa subunit family. http://togogenome.org/gene/243274:THEMA_RS02465 ^@ http://purl.uniprot.org/uniprot/G4FE21|||http://purl.uniprot.org/uniprot/Q9WYT0 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the thymidylate synthase ThyX family.|||Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP or deoxyuridylate) to 2'-deoxythymidine-5'-monophosphate (dTMP or deoxythymidylate) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methylene donor, and NAD(P)H and FADH(2) as the reductant. This reaction is a critical step in DNA biosynthesis (PubMed:12791256, PubMed:19370033). Can also use formaldehyde instead of mTHF as a direct methylene donor for dTMP synthesis. However, the tighter binding of ThyX to mTHF (KD of 4 uM) compared to formaldehyde (KD of 20 mM) confirms that methylene tetrahydrofolate acts as the biological carbon donor for ThyX, serving as a formaldehyde carrier/transporter and thus avoiding genotoxic effects (PubMed:34315871).|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.|||Homotetramer.|||Reaction mechanism involved a direct methylene transfer from mTHF to dUMP (PubMed:23019356). FDTS ionizes N3 of dUMP using the active-site Arg-174, providing a new mechanism for dUMP activation. The phosphate of dUMP is crucial for flavin oxidation, suggesting that it acts as the base that deprotonates C5 of the dUMP-methylene adduct (PubMed:27214228). A later study showed that FAD is first reduced by NADPH. Then, the reduced flavin, FADH(-), reacts with mTHF to form a carbinolamine flavin, which acts as the genuine methylene donor. The flavin carbinolamine can be obtained directly via a CH2O-shunt reaction consisting of a reaction of FADH(-) with free CH2O. Methylene transfer from FAD to dUMP is initiated by an SN2 reaction of activated dUMP and the flavin carbinolamine, leading to water elimination and formation of a transient FAD-CH2-dUMP adduct (PubMed:34315871). http://togogenome.org/gene/243274:THEMA_RS01040 ^@ http://purl.uniprot.org/uniprot/Q9WZI3|||http://purl.uniprot.org/uniprot/R4NPL1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS05720 ^@ http://purl.uniprot.org/uniprot/G4FG77|||http://purl.uniprot.org/uniprot/Q9X216 ^@ Similarity ^@ Belongs to the RemA family. http://togogenome.org/gene/243274:THEMA_RS01160 ^@ http://purl.uniprot.org/uniprot/Q56311 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. http://togogenome.org/gene/243274:THEMA_RS03325 ^@ http://purl.uniprot.org/uniprot/G4FHJ0|||http://purl.uniprot.org/uniprot/Q9WYB3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the arabinose isomerase family.|||Binds 1 Mn(2+) ion per subunit.|||Catalyzes the conversion of L-arabinose to L-ribulose. http://togogenome.org/gene/243274:THEMA_RS05030 ^@ http://purl.uniprot.org/uniprot/G4FGL2|||http://purl.uniprot.org/uniprot/Q9X2E5 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/243274:THEMA_RS03745 ^@ http://purl.uniprot.org/uniprot/G4FHA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0014 family.|||Membrane http://togogenome.org/gene/243274:THEMA_RS00490 ^@ http://purl.uniprot.org/uniprot/Q9WZT7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. MtaB subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS00530 ^@ http://purl.uniprot.org/uniprot/G4FD02|||http://purl.uniprot.org/uniprot/Q9WZS9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/243274:THEMA_RS06820 ^@ http://purl.uniprot.org/uniprot/G4FFL7|||http://purl.uniprot.org/uniprot/Q9X1I9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell inner membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/243274:THEMA_RS08715 ^@ http://purl.uniprot.org/uniprot/Q9X0J4|||http://purl.uniprot.org/uniprot/R4NQI6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS00385 ^@ http://purl.uniprot.org/uniprot/G4FCX3|||http://purl.uniprot.org/uniprot/Q9WZV5 ^@ Function|||Similarity ^@ Belongs to the HrcA family.|||Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. http://togogenome.org/gene/243274:THEMA_RS08480 ^@ http://purl.uniprot.org/uniprot/G4FEJ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS08680 ^@ http://purl.uniprot.org/uniprot/Q9X0K1|||http://purl.uniprot.org/uniprot/R4P0B7 ^@ Similarity ^@ Belongs to the bacterial secretin family. http://togogenome.org/gene/243274:THEMA_RS07430 ^@ http://purl.uniprot.org/uniprot/Q9X185|||http://purl.uniprot.org/uniprot/R4NST7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family.|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each. http://togogenome.org/gene/243274:THEMA_RS08290 ^@ http://purl.uniprot.org/uniprot/G4FEF4 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 36 family.|||Homodimer.|||Hydrolyzes the short-chain alpha-galactosaccharides raffinose, melibiose and stachyose.|||Inhibited by hydrolyzation product alpha-galactopyranose and to a lesser extent by beta-galactopyranose, its mutarotational product (PubMed:26005928). Inhibited by synthetic cyclopropyl carbasugars (PubMed:27783466). http://togogenome.org/gene/243274:THEMA_RS03690 ^@ http://purl.uniprot.org/uniprot/Q9WY46|||http://purl.uniprot.org/uniprot/R4NXV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS09030 ^@ http://purl.uniprot.org/uniprot/Q9X0D8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/243274:THEMA_RS08205 ^@ http://purl.uniprot.org/uniprot/Q9X0T6|||http://purl.uniprot.org/uniprot/R4NQT6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS02115 ^@ http://purl.uniprot.org/uniprot/Q9WYY3|||http://purl.uniprot.org/uniprot/R4NYD0 ^@ Similarity ^@ Belongs to the Mg-chelatase subunits D/I family. ComM subfamily. http://togogenome.org/gene/243274:THEMA_RS02955 ^@ http://purl.uniprot.org/uniprot/G4FHR1|||http://purl.uniprot.org/uniprot/Q9WYI4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type-II 3-dehydroquinase family.|||Catalyzes a trans-dehydration via an enolate intermediate.|||Homododecamer. http://togogenome.org/gene/243274:THEMA_RS00080 ^@ http://purl.uniprot.org/uniprot/G4FCR5|||http://purl.uniprot.org/uniprot/Q9X013 ^@ Function|||Similarity ^@ Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/243274:THEMA_RS05305 ^@ http://purl.uniprot.org/uniprot/Q9X292|||http://purl.uniprot.org/uniprot/R4P1X7 ^@ Similarity ^@ Belongs to the asp23 family. http://togogenome.org/gene/243274:THEMA_RS06490 ^@ http://purl.uniprot.org/uniprot/Q9X1N0|||http://purl.uniprot.org/uniprot/R4NT98 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS06775 ^@ http://purl.uniprot.org/uniprot/G4FFM6|||http://purl.uniprot.org/uniprot/P38513 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/243274:THEMA_RS04275 ^@ http://purl.uniprot.org/uniprot/Q9WXV2|||http://purl.uniprot.org/uniprot/R4NMP9 ^@ Function|||Similarity ^@ Belongs to the NadD family.|||Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). http://togogenome.org/gene/243274:THEMA_RS01500 ^@ http://purl.uniprot.org/uniprot/Q9WZA0|||http://purl.uniprot.org/uniprot/R4P111 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial sugar transferase family.|||Membrane http://togogenome.org/gene/243274:THEMA_RS03385 ^@ http://purl.uniprot.org/uniprot/Q9WYA2|||http://purl.uniprot.org/uniprot/R4P009 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/243274:THEMA_RS04030 ^@ http://purl.uniprot.org/uniprot/G4FH60|||http://purl.uniprot.org/uniprot/Q9WXZ3 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/243274:THEMA_RS07440 ^@ http://purl.uniprot.org/uniprot/G4FF99|||http://purl.uniprot.org/uniprot/Q9X183 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1 (By similarity).|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/243274:THEMA_RS04215 ^@ http://purl.uniprot.org/uniprot/G4FH24 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/243274:THEMA_RS02330 ^@ http://purl.uniprot.org/uniprot/G4FDZ7|||http://purl.uniprot.org/uniprot/Q9WYU4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||Homohexamer and homododecamer. In the presence of PdxT, forms a dodecamer of heterodimers.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/243274:THEMA_RS04260 ^@ http://purl.uniprot.org/uniprot/G4FH15|||http://purl.uniprot.org/uniprot/Q9WXV5 ^@ Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. http://togogenome.org/gene/243274:THEMA_RS02410 ^@ http://purl.uniprot.org/uniprot/G4FE14|||http://purl.uniprot.org/uniprot/P29394 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors (such as IF-2, EF-Tu, EF-G and RF3).|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and 23S rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which 3 L12 dimers bind in a sequential fashion forming a heptameric L10(L12)2(L12)2(L12)2 complex.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/243274:THEMA_RS04835 ^@ http://purl.uniprot.org/uniprot/G4FGQ1|||http://purl.uniprot.org/uniprot/P36203 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS08620 ^@ http://purl.uniprot.org/uniprot/Q9X0L3 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.|||Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. http://togogenome.org/gene/243274:THEMA_RS08860 ^@ http://purl.uniprot.org/uniprot/G4FER6|||http://purl.uniprot.org/uniprot/O33927 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the peptidase S24 family.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||No consensus sequence similar to the SOS-box from E.coli or from B.subtilis was found upstream of the lexA gene, suggesting the presence of another target sequence specific for the Thermotogales.|||Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. http://togogenome.org/gene/243274:THEMA_RS03900 ^@ http://purl.uniprot.org/uniprot/G4FH86|||http://purl.uniprot.org/uniprot/O51933 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/243274:THEMA_RS08585 ^@ http://purl.uniprot.org/uniprot/Q9X0M0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS02050 ^@ http://purl.uniprot.org/uniprot/G4FDU6|||http://purl.uniprot.org/uniprot/Q9WYZ5 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/243274:THEMA_RS00290 ^@ http://purl.uniprot.org/uniprot/Q9WZX3|||http://purl.uniprot.org/uniprot/R4NRF4 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS00830 ^@ http://purl.uniprot.org/uniprot/R4NPN9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS04070 ^@ http://purl.uniprot.org/uniprot/G4FH53|||http://purl.uniprot.org/uniprot/Q56320 ^@ Similarity|||Subunit ^@ Belongs to the TrpF family.|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS03665 ^@ http://purl.uniprot.org/uniprot/Q9WY51|||http://purl.uniprot.org/uniprot/R4NXW0 ^@ Activity Regulation|||Similarity|||Subunit ^@ Allosterically activated by AMP and inhibited by ATP.|||Belongs to the pyruvate kinase family.|||Homotetramer. http://togogenome.org/gene/243274:THEMA_RS00625 ^@ http://purl.uniprot.org/uniprot/Q9WZR2|||http://purl.uniprot.org/uniprot/R4NRA0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS03370 ^@ http://purl.uniprot.org/uniprot/G4FHI1|||http://purl.uniprot.org/uniprot/Q9WYA4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS04025 ^@ http://purl.uniprot.org/uniprot/Q9WXZ4|||http://purl.uniprot.org/uniprot/R4NPG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Iojap/RsfS family.|||Cytoplasm|||Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.|||Interacts with ribosomal protein uL14 (rplN). http://togogenome.org/gene/243274:THEMA_RS07280 ^@ http://purl.uniprot.org/uniprot/Q9X1B1|||http://purl.uniprot.org/uniprot/R4P136 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/243274:THEMA_RS02750 ^@ http://purl.uniprot.org/uniprot/Q9WYM4|||http://purl.uniprot.org/uniprot/R4NNI4 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/243274:THEMA_RS08655 ^@ http://purl.uniprot.org/uniprot/Q9X0K6|||http://purl.uniprot.org/uniprot/R4P0C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS00120 ^@ http://purl.uniprot.org/uniprot/G4FCS3|||http://purl.uniprot.org/uniprot/Q9X005 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CheD family.|||Deamidates glutamine residues on chemoreceptors (MCPs). CheD-mediated MCP deamidation is required for productive communication of the conformational signals of the chemoreceptors to the CheA kinase. In addition, demethylates methylated glutamate residues on chemoreceptors Mcp2 and Mcp4. Enhances the activity of CheC.|||Heterodimer with CheC. The CheC-CheD heterodimer interacts with phosphorylated CheY.|||Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis. http://togogenome.org/gene/243274:THEMA_RS05995 ^@ http://purl.uniprot.org/uniprot/Q9X1X1 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the SMC family. RAD50 subfamily.|||Binds 1 zinc ion per homodimer.|||Homodimer. Forms a complex with Mre11 (By similarity).|||Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site (By similarity).|||The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer (By similarity). http://togogenome.org/gene/243274:THEMA_RS07850 ^@ http://purl.uniprot.org/uniprot/G4FE67|||http://purl.uniprot.org/uniprot/Q9X108 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 4 family.|||Binds 1 Mn(2+) ion per subunit.|||Binds 1 NAD(+) per subunit.|||Homodimer or homotetramer. Exists in a homodimer/homotetramer equilibrium state in solution.|||Hydrolyzes cellobiose 6'-phosphate into glucose 6-phosphate (Glc6P) and glucose.|||Is a retaining glucosidase as it hydrolyzes glycosidic bond with retention of anomeric configuration. Reaction mechanism includes redox steps involving NAD and stabilization of intermediates by Mn(2+). http://togogenome.org/gene/243274:THEMA_RS07215 ^@ http://purl.uniprot.org/uniprot/Q9X1C4|||http://purl.uniprot.org/uniprot/R4NRA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS08395 ^@ http://purl.uniprot.org/uniprot/G4FEH4|||http://purl.uniprot.org/uniprot/Q9X0Q4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HCP family.|||Binds 1 [4Fe-4S] cluster.|||Binds 1 hybrid [4Fe-2O-2S] cluster.|||Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS06170 ^@ http://purl.uniprot.org/uniprot/Q9X1T8 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 Ni(2+) ion per monomer; it is not certain this is the physiological metal.|||Homodimer.|||Probably functions to regulate transcription of NAD metabolic genes. Binds to DNA upstream of the probable nadBII/nadA/nadC and niaRP operons in a nicotinic acid dependent fashion. Nicotinic acid may be a corepressor. http://togogenome.org/gene/243274:THEMA_RS02770 ^@ http://purl.uniprot.org/uniprot/Q9WYL8|||http://purl.uniprot.org/uniprot/R4NNI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS02700 ^@ http://purl.uniprot.org/uniprot/Q9WYN3|||http://purl.uniprot.org/uniprot/R4NY33 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/243274:THEMA_RS06770 ^@ http://purl.uniprot.org/uniprot/G4FFM7|||http://purl.uniprot.org/uniprot/P38508 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/243274:THEMA_RS07470 ^@ http://purl.uniprot.org/uniprot/Q9X178|||http://purl.uniprot.org/uniprot/R4P300 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Monomer. http://togogenome.org/gene/243274:THEMA_RS05450 ^@ http://purl.uniprot.org/uniprot/Q9X266|||http://purl.uniprot.org/uniprot/R4NTX8 ^@ Similarity ^@ Belongs to the threonine aldolase family. http://togogenome.org/gene/243274:THEMA_RS06225 ^@ http://purl.uniprot.org/uniprot/G4FFX9|||http://purl.uniprot.org/uniprot/Q9X1S7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/243274:THEMA_RS02845 ^@ http://purl.uniprot.org/uniprot/G4FHT3|||http://purl.uniprot.org/uniprot/Q9WW19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ArgR family.|||Cytoplasm|||Regulates arginine biosynthesis genes. http://togogenome.org/gene/243274:THEMA_RS05785 ^@ http://purl.uniprot.org/uniprot/Q9X205|||http://purl.uniprot.org/uniprot/R4P1K4 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/243274:THEMA_RS05920 ^@ http://purl.uniprot.org/uniprot/G4FG40|||http://purl.uniprot.org/uniprot/Q9X1Y4 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. http://togogenome.org/gene/243274:THEMA_RS02800 ^@ http://purl.uniprot.org/uniprot/Q9WYL2|||http://purl.uniprot.org/uniprot/R4NY14 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/243274:THEMA_RS07330 ^@ http://purl.uniprot.org/uniprot/G4FFB9|||http://purl.uniprot.org/uniprot/Q9X1A3 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. IspE subfamily.|||Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. http://togogenome.org/gene/243274:THEMA_RS07095 ^@ http://purl.uniprot.org/uniprot/G4FFG2|||http://purl.uniprot.org/uniprot/Q9X1E1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional regulatory Rex family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.|||This protein lacks the conserved Gly residues in positions 90 and 93 that are potentially involved in NAD(H) binding. They are replaced by an Asn and an Ala, respectively. http://togogenome.org/gene/243274:THEMA_RS04975 ^@ http://purl.uniprot.org/uniprot/G4FGM3|||http://purl.uniprot.org/uniprot/G4XU76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.|||Cell membrane|||Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/243274:THEMA_RS07435 ^@ http://purl.uniprot.org/uniprot/Q9X184|||http://purl.uniprot.org/uniprot/R4NR68 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family.|||Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.|||The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod. http://togogenome.org/gene/243274:THEMA_RS03885 ^@ http://purl.uniprot.org/uniprot/Q9WY19|||http://purl.uniprot.org/uniprot/R4NXG3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS04865 ^@ http://purl.uniprot.org/uniprot/Q9X2G8|||http://purl.uniprot.org/uniprot/R4P2E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS00655 ^@ http://purl.uniprot.org/uniprot/Q9WZQ6|||http://purl.uniprot.org/uniprot/R4NPR3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BioY family.|||Cell inner membrane|||Cell membrane|||Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component, RibU, BioY), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component) upon coexpression in E.coli. A stable subcomplex with both A and T components are also isolated. This complex interacts with at least 2 substrate-specific components, BioY and RibU.|||Substrate-binding (S) component of an energy-coupling factor (ECF) ABC-transporter complex. Probably a biotin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins (Probable). http://togogenome.org/gene/243274:THEMA_RS08875 ^@ http://purl.uniprot.org/uniprot/G4FER9|||http://purl.uniprot.org/uniprot/Q9X0G8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. PrmA family.|||Cytoplasm|||Methylates ribosomal protein L11. http://togogenome.org/gene/243274:THEMA_RS05025 ^@ http://purl.uniprot.org/uniprot/G4FGL3|||http://purl.uniprot.org/uniprot/Q9X2E6 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion per subunit.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.|||In the C-terminal section; belongs to the GTP cyclohydrolase II family.|||In the N-terminal section; belongs to the DHBP synthase family. http://togogenome.org/gene/243274:THEMA_RS06000 ^@ http://purl.uniprot.org/uniprot/Q9X1X0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SbcD family.|||Heterodimer of SbcC and SbcD.|||SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity. http://togogenome.org/gene/243274:THEMA_RS02945 ^@ http://purl.uniprot.org/uniprot/Q9WYI6|||http://purl.uniprot.org/uniprot/R4NXZ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS06730 ^@ http://purl.uniprot.org/uniprot/G4FFN5|||http://purl.uniprot.org/uniprot/P38512 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/243274:THEMA_RS04075 ^@ http://purl.uniprot.org/uniprot/G4FH52|||http://purl.uniprot.org/uniprot/P50909 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/243274:THEMA_RS05845 ^@ http://purl.uniprot.org/uniprot/Q9X1Z4|||http://purl.uniprot.org/uniprot/R4P1J1 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/243274:THEMA_RS02520 ^@ http://purl.uniprot.org/uniprot/Q9WYR9|||http://purl.uniprot.org/uniprot/R4NNM3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS05410 ^@ http://purl.uniprot.org/uniprot/Q9X274|||http://purl.uniprot.org/uniprot/R4P1V9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/243274:THEMA_RS06930 ^@ http://purl.uniprot.org/uniprot/Q9X1H1|||http://purl.uniprot.org/uniprot/R4NRF7 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.|||Belongs to the KhpB RNA-binding protein family.|||Cytoplasm|||Forms a complex with KhpA.|||Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH and R3H).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS05520 ^@ http://purl.uniprot.org/uniprot/G4FGB6|||http://purl.uniprot.org/uniprot/Q56313 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvB family.|||Cytoplasm|||Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.|||Homohexamer (PubMed:11478862). Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Promotes Holliday junction (HJ) branch migration in conjunction with RuvA. Subunits can be free, ADP- or ATP-bound; nucleotide binding changes during the reaction cycle (PubMed:11478862). Has a DNA-dependent ATPase activity; dsDNA and supercoiled DNA but not ssDNA stimulate activity (PubMed:8626340, PubMed:11478862).|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA. http://togogenome.org/gene/243274:THEMA_RS00185 ^@ http://purl.uniprot.org/uniprot/G4FCT5|||http://purl.uniprot.org/uniprot/Q9WZZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS04395 ^@ http://purl.uniprot.org/uniprot/G4FGY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS02110 ^@ http://purl.uniprot.org/uniprot/G4FDV7|||http://purl.uniprot.org/uniprot/Q9WYY4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.|||Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS08345 ^@ http://purl.uniprot.org/uniprot/Q9X0R4|||http://purl.uniprot.org/uniprot/R4P2J7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/243274:THEMA_RS06315 ^@ http://purl.uniprot.org/uniprot/G4FFW6|||http://purl.uniprot.org/uniprot/Q9X1R4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell inner membrane|||Cytoplasm|||Monomer and homodimer (By similarity). Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved. A single SecA monomer interacts with SecY in the channel.|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/243274:THEMA_RS01230 ^@ http://purl.uniprot.org/uniprot/G4FDD7|||http://purl.uniprot.org/uniprot/Q9WZF3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YbaB/EbfC family.|||Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.|||Homodimer.|||nucleoid http://togogenome.org/gene/243274:THEMA_RS05690 ^@ http://purl.uniprot.org/uniprot/Q9X222|||http://purl.uniprot.org/uniprot/R4P3Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A24 family.|||Membrane http://togogenome.org/gene/243274:THEMA_RS01920 ^@ http://purl.uniprot.org/uniprot/G4FDS0|||http://purl.uniprot.org/uniprot/Q9WZ21 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS08660 ^@ http://purl.uniprot.org/uniprot/G4FEM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS07245 ^@ http://purl.uniprot.org/uniprot/G4FFD4|||http://purl.uniprot.org/uniprot/Q9X1B8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS07735 ^@ http://purl.uniprot.org/uniprot/G4FE45 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS08005 ^@ http://purl.uniprot.org/uniprot/G4FE98 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/243274:THEMA_RS02640 ^@ http://purl.uniprot.org/uniprot/Q9WYP5 ^@ Function|||Similarity ^@ Belongs to the Gfo/Idh/MocA family.|||Catalyzes the NAD(+)-dependent oxidation of myo-inositol (MI) to 2-keto-myo-inositol (scyllo-inosose), and thus probably functions in a myo-inositol degradation pathway together with IolM, IolN and IolO. Has no activity with scyllo-inositol and much reduced activity (78-fold lower catalytic efficiency) with 1D-chiro-inositol. http://togogenome.org/gene/243274:THEMA_RS07230 ^@ http://purl.uniprot.org/uniprot/Q9X1C1 ^@ Function|||Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Involved in the degradation of L-serine via 3-hydroxypyruvate. Catalyzes the non-reversible reduction of 3-hydroxypyruvate to yield D-glycerate. http://togogenome.org/gene/243274:THEMA_RS05155 ^@ http://purl.uniprot.org/uniprot/Q9X2B9 ^@ Similarity ^@ In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.|||In the central section; belongs to the CRISPR-associated helicase Cas3 family. http://togogenome.org/gene/243274:THEMA_RS05355 ^@ http://purl.uniprot.org/uniprot/G4FGE8|||http://purl.uniprot.org/uniprot/Q9X282 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/243274:THEMA_RS08100 ^@ http://purl.uniprot.org/uniprot/Q9X0V7 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase group 1 family.|||Catalyzes the synthesis of mannosylglucosylglycerate (MGG) from glucosylglycerate (GG) and GDP-mannose. http://togogenome.org/gene/243274:THEMA_RS04380 ^@ http://purl.uniprot.org/uniprot/Q9WXT1|||http://purl.uniprot.org/uniprot/R4NX63 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/243274:THEMA_RS06010 ^@ http://purl.uniprot.org/uniprot/Q9X1W8|||http://purl.uniprot.org/uniprot/R4NTI8 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/243274:THEMA_RS05530 ^@ http://purl.uniprot.org/uniprot/G4FGB4|||http://purl.uniprot.org/uniprot/Q9X251 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/243274:THEMA_RS03870 ^@ http://purl.uniprot.org/uniprot/G4FH92|||http://purl.uniprot.org/uniprot/Q9WY22 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. PriA subfamily.|||Component of the primosome.|||Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. http://togogenome.org/gene/243274:THEMA_RS03630 ^@ http://purl.uniprot.org/uniprot/Q9WY58|||http://purl.uniprot.org/uniprot/R4NXK7 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/243274:THEMA_RS06995 ^@ http://purl.uniprot.org/uniprot/G4FFI2|||http://purl.uniprot.org/uniprot/Q9X1F9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsY family.|||Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.|||Cell inner membrane|||Probably interacts with PlsX. http://togogenome.org/gene/243274:THEMA_RS03595 ^@ http://purl.uniprot.org/uniprot/Q9WY65 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (Probable). Expression of the complex plus RibU in E.coli allows riboflavin uptake; uptake does not occur in the absence of RibU or the EcfA1A2T complex.|||Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.|||Cell inner membrane|||Forms a heterodimer with EcfA1. Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component, RibU, BioY), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component) upon coexpression in E.coli. Stable subcomplexes with both A plus T components can also be isolated. This complex interacts with at least 2 substrate-specific components, BioY and RibU.|||Structure 4HLU is probably in the open state. http://togogenome.org/gene/243274:THEMA_RS08330 ^@ http://purl.uniprot.org/uniprot/G4FEG1 ^@ Function|||Similarity ^@ Belongs to the methylglyoxal synthase family.|||Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. http://togogenome.org/gene/243274:THEMA_RS00775 ^@ http://purl.uniprot.org/uniprot/G4FD48|||http://purl.uniprot.org/uniprot/Q9WZN3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/243274:THEMA_RS02475 ^@ http://purl.uniprot.org/uniprot/Q9WYS8|||http://purl.uniprot.org/uniprot/R4NY74 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS01745 ^@ http://purl.uniprot.org/uniprot/Q9WZ53|||http://purl.uniprot.org/uniprot/R4NYV5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS04330 ^@ http://purl.uniprot.org/uniprot/G4FH01|||http://purl.uniprot.org/uniprot/Q9WXU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurJ/MviN family.|||Cell inner membrane|||Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.|||Membrane http://togogenome.org/gene/243274:THEMA_RS03120 ^@ http://purl.uniprot.org/uniprot/Q9WYF3|||http://purl.uniprot.org/uniprot/R4NPW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/243274:THEMA_RS04270 ^@ http://purl.uniprot.org/uniprot/G4FH13|||http://purl.uniprot.org/uniprot/Q9WXV3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/243274:THEMA_RS04670 ^@ http://purl.uniprot.org/uniprot/Q56317 ^@ Cofactor|||Subunit ^@ Binds 1 [4Fe-4S] cluster per subunit.|||Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/243274:THEMA_RS05165 ^@ http://purl.uniprot.org/uniprot/Q9X2B7|||http://purl.uniprot.org/uniprot/R4NU25 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer (Probable). Forms a heterotetramer with a Cas2 homodimer (By similarity).|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/243274:THEMA_RS05600 ^@ http://purl.uniprot.org/uniprot/G4FGA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurB family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS08890 ^@ http://purl.uniprot.org/uniprot/Q9X0G5|||http://purl.uniprot.org/uniprot/R4NZX0 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/243274:THEMA_RS03790 ^@ http://purl.uniprot.org/uniprot/Q9WY31|||http://purl.uniprot.org/uniprot/R4NXT8 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/243274:THEMA_RS04940 ^@ http://purl.uniprot.org/uniprot/G4FGN0|||http://purl.uniprot.org/uniprot/O33840 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/243274:THEMA_RS02075 ^@ http://purl.uniprot.org/uniprot/G4FDV0|||http://purl.uniprot.org/uniprot/Q9WYZ1 ^@ Activity Regulation|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||According to PubMed:12646382 the propeptide is autoprocessed in 20% of the cases in the expression system (E.coli).|||Allosterically activated by HslU binding.|||Belongs to the peptidase T1B family. HslV subfamily.|||Cytoplasm|||Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. http://togogenome.org/gene/243274:THEMA_RS08065 ^@ http://purl.uniprot.org/uniprot/Q9X0W5|||http://purl.uniprot.org/uniprot/R4P2S5 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/243274:THEMA_RS09630 ^@ http://purl.uniprot.org/uniprot/P56728 ^@ Caution ^@ Was originally proposed to be fused with TM_0929. http://togogenome.org/gene/243274:THEMA_RS01795 ^@ http://purl.uniprot.org/uniprot/G4FDP5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvC family.|||Binds 2 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/243274:THEMA_RS08025 ^@ http://purl.uniprot.org/uniprot/Q9X0X3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.|||Purl possesses an auxiliary ATP Binding region which is not catalytic, but able to bind additional ATP. The conformational changes associated with its binding could have a regulatory role in formation of the PurLSQ complex (PubMed:17154526). http://togogenome.org/gene/243274:THEMA_RS02035 ^@ http://purl.uniprot.org/uniprot/G4FDU3|||http://purl.uniprot.org/uniprot/Q9WYZ8 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/243274:THEMA_RS01940 ^@ http://purl.uniprot.org/uniprot/G4FDS4 ^@ Similarity ^@ Belongs to the aspartokinase family.|||In the C-terminal section; belongs to the homoserine dehydrogenase family.|||In the N-terminal section; belongs to the aspartokinase family. http://togogenome.org/gene/243274:THEMA_RS04795 ^@ http://purl.uniprot.org/uniprot/G4FGQ9|||http://purl.uniprot.org/uniprot/P16115 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by fructose 1,6-bisphosphate (FBP).|||Allosterically activated by fructose 1,6-bisphosphate (FBP). Inactivated by Mn(2+), Co(2+), Cd(2+) and Zn(2+).|||Belongs to the LDH/MDH superfamily. LDH family.|||Catalyzes the conversion of lactate to pyruvate.|||Catalyzes the conversion of lactate to pyruvate. It is stereospecific for L(+)-lactate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS07285 ^@ http://purl.uniprot.org/uniprot/Q9X1B0|||http://purl.uniprot.org/uniprot/R4NSV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS08130 ^@ http://purl.uniprot.org/uniprot/Q9X0V1|||http://purl.uniprot.org/uniprot/R4NQX8 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/243274:THEMA_RS07365 ^@ http://purl.uniprot.org/uniprot/G4FFB2|||http://purl.uniprot.org/uniprot/Q9X196 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.|||Cell inner membrane|||Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD). http://togogenome.org/gene/243274:THEMA_RS04420 ^@ http://purl.uniprot.org/uniprot/Q9WXS3 ^@ Function|||Similarity ^@ Belongs to the mannitol dehydrogenase family. UxuB subfamily.|||Catalyzes the reduction of D-fructuronate (D-FruA) to D-mannonate (D-ManA). http://togogenome.org/gene/243274:THEMA_RS04785 ^@ http://purl.uniprot.org/uniprot/Q9X2I2|||http://purl.uniprot.org/uniprot/R4P4E5 ^@ Similarity ^@ Belongs to the peptidase S16 family. http://togogenome.org/gene/243274:THEMA_RS01165 ^@ http://purl.uniprot.org/uniprot/Q56312 ^@ Cofactor|||Function|||PTM|||Subcellular Location Annotation ^@ Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY seems to regulate the clockwise (CW) rotation (By similarity).|||Phosphorylated by CheA. http://togogenome.org/gene/243274:THEMA_RS08020 ^@ http://purl.uniprot.org/uniprot/Q9X0X4|||http://purl.uniprot.org/uniprot/R4NSJ2 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/243274:THEMA_RS07955 ^@ http://purl.uniprot.org/uniprot/Q9X0Y7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/243274:THEMA_RS07780 ^@ http://purl.uniprot.org/uniprot/Q9X120|||http://purl.uniprot.org/uniprot/R4NSM8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS00015 ^@ http://purl.uniprot.org/uniprot/Q9X026|||http://purl.uniprot.org/uniprot/R4NRJ9 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/243274:THEMA_RS06970 ^@ http://purl.uniprot.org/uniprot/G4FFI7|||http://purl.uniprot.org/uniprot/Q9X1G3 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Binds two Mg(2+) per subunit.|||Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/243274:THEMA_RS00275 ^@ http://purl.uniprot.org/uniprot/G4FCV3|||http://purl.uniprot.org/uniprot/Q9WZX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmH family.|||Cytoplasm|||Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. http://togogenome.org/gene/243274:THEMA_RS02525 ^@ http://purl.uniprot.org/uniprot/Q9WYR8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 28 family. http://togogenome.org/gene/243274:THEMA_RS06115 ^@ http://purl.uniprot.org/uniprot/G4FG01|||http://purl.uniprot.org/uniprot/Q9X1U8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase delta chain family.|||Cell inner membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. http://togogenome.org/gene/243274:THEMA_RS00190 ^@ http://purl.uniprot.org/uniprot/G4FCT6|||http://purl.uniprot.org/uniprot/Q9WZZ1 ^@ Caution|||Function|||Similarity ^@ Belongs to the DXR family.|||Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS02875 ^@ http://purl.uniprot.org/uniprot/G4FHS7|||http://purl.uniprot.org/uniprot/Q9WYJ9 ^@ Similarity ^@ Belongs to the peptidase M18 family. http://togogenome.org/gene/243274:THEMA_RS05400 ^@ http://purl.uniprot.org/uniprot/G4FGE0|||http://purl.uniprot.org/uniprot/Q9X276 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetokinase family.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS07905 ^@ http://purl.uniprot.org/uniprot/Q9X0Z7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the trans-sulfuration enzymes family.|||Catalyzes the racemization of L-alanine to D-alanine, and of L-glutamate to D-glutamate. The activity is low, but likely physiological since T.maritima lacks canonical alr and murI genes, while D-alanine and D-glutamate are essential components of peptidoglycan. Also displays a more efficient cystathionine beta-lyase (CBL) activity, cleaving cystathionine to homocysteine and pyruvate; however, this reaction seems not to be physiologically relevant since T.maritima possesses an O-acetyl-homoserine thiolase (MetY) that bypasses the need of CBL for methionine biosynthesis. Is not able to produce cystathionine, using either O-acetylhomoserine or O-succinylhomoserine, plus L-cysteine as substrates, and thus does not possess cystathionine gamma-synthase (CGS) activity.|||Homotetramer; dimer of active dimers. http://togogenome.org/gene/243274:THEMA_RS00115 ^@ http://purl.uniprot.org/uniprot/Q9X006 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CheC family.|||Heterodimer with CheD. The CheC-CheD heterodimer interacts with phosphorylated CheY. The CheC-CheD dimer has higher phosphatase activity than CheC alone.|||Involved in restoring normal CheY-P levels by dephosphorylating CheY-P. Inhibits CheD by incorporating in its fold a structural motif that mimics a CheD substrate recognition site to bait and inactivate it. http://togogenome.org/gene/243274:THEMA_RS06390 ^@ http://purl.uniprot.org/uniprot/Q9X1P9|||http://purl.uniprot.org/uniprot/R4NRQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/243274:THEMA_RS02930 ^@ http://purl.uniprot.org/uniprot/Q9WYI9|||http://purl.uniprot.org/uniprot/R4NYA5 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/243274:THEMA_RS06635 ^@ http://purl.uniprot.org/uniprot/G4FFQ4|||http://purl.uniprot.org/uniprot/Q9X1K5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/243274:THEMA_RS07145 ^@ http://purl.uniprot.org/uniprot/G4FFF2 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/243274:THEMA_RS03250 ^@ http://purl.uniprot.org/uniprot/G4FHK5|||http://purl.uniprot.org/uniprot/Q9WYC7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/243274:THEMA_RS04740 ^@ http://purl.uniprot.org/uniprot/Q9X2J1|||http://purl.uniprot.org/uniprot/R4P2G4 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/243274:THEMA_RS07865 ^@ http://purl.uniprot.org/uniprot/G4FE70|||http://purl.uniprot.org/uniprot/Q9X105 ^@ Activity Regulation|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.|||Contains an N-terminal DNA-binding domain, followed by a dimerization domain and a C-terminal domain, called the small MutS-related (Smr) domain, which is absent from MutS and contains the endonuclease activity.|||Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity (Probable). Has ATPase activity. Binds to DNA.|||Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.|||Homodimer.|||Homodimer. Interacts with MutL.|||Nuclease activity is stimulated by interaction with MutL and inhibited in the presence of non-hydrolytic ATP (ADPnP). ATPase activity is stimulated by DNA. http://togogenome.org/gene/243274:THEMA_RS01335 ^@ http://purl.uniprot.org/uniprot/Q9WZD4 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/243274:THEMA_RS09960 ^@ http://purl.uniprot.org/uniprot/Q9WYT4|||http://purl.uniprot.org/uniprot/R4NNQ0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/243274:THEMA_RS03380 ^@ http://purl.uniprot.org/uniprot/G4FHH9|||http://purl.uniprot.org/uniprot/Q9WYA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/243274:THEMA_RS09635 ^@ http://purl.uniprot.org/uniprot/G4FF63|||http://purl.uniprot.org/uniprot/P46797 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 [4Fe-4S] cluster.|||Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.|||Monomer. http://togogenome.org/gene/243274:THEMA_RS05735 ^@ http://purl.uniprot.org/uniprot/Q9X213|||http://purl.uniprot.org/uniprot/R4P1L4 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS04750 ^@ http://purl.uniprot.org/uniprot/Q9X2I9|||http://purl.uniprot.org/uniprot/R4NSM0 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/243274:THEMA_RS08790 ^@ http://purl.uniprot.org/uniprot/G4FEQ2|||http://purl.uniprot.org/uniprot/Q9X0I0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/243274:THEMA_RS02430 ^@ http://purl.uniprot.org/uniprot/G4FE18|||http://purl.uniprot.org/uniprot/P35874 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell inner membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with SecDF, and other proteins may be involved. The channel interacts with SecA via subunit SecY.|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.|||Essential subunit of the protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. http://togogenome.org/gene/243274:THEMA_RS06440 ^@ http://purl.uniprot.org/uniprot/G4FFU1 ^@ Cofactor|||Similarity ^@ Belongs to the ApbE family.|||Magnesium. Can also use manganese. http://togogenome.org/gene/243274:THEMA_RS09450 ^@ http://purl.uniprot.org/uniprot/Q9X058|||http://purl.uniprot.org/uniprot/R4NQ54 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/243274:THEMA_RS05750 ^@ http://purl.uniprot.org/uniprot/G4FG71|||http://purl.uniprot.org/uniprot/O54311 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.|||Binds 1 zinc ion per subunit.|||Binds the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/243274:THEMA_RS09380 ^@ http://purl.uniprot.org/uniprot/Q9X073|||http://purl.uniprot.org/uniprot/R4NRP2 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/243274:THEMA_RS05085 ^@ http://purl.uniprot.org/uniprot/Q9X2D4|||http://purl.uniprot.org/uniprot/R4P4A5 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/243274:THEMA_RS07030 ^@ http://purl.uniprot.org/uniprot/Q9X1F3|||http://purl.uniprot.org/uniprot/R4NRD5 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/243274:THEMA_RS06445 ^@ http://purl.uniprot.org/uniprot/Q9X1N8|||http://purl.uniprot.org/uniprot/R4P185 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/243274:THEMA_RS06280 ^@ http://purl.uniprot.org/uniprot/Q9X1S1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glycerate kinase type-1 family.|||Homodimer.|||Involved in the degradation of serine via 3-hydroxypyruvate. Catalyzes the ATP-dependent phosphorylation of D-glycerate to 2-phosphoglycerate. http://togogenome.org/gene/243274:THEMA_RS01805 ^@ http://purl.uniprot.org/uniprot/G4FDP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.|||Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.|||Cell inner membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS06155 ^@ http://purl.uniprot.org/uniprot/G4FFZ3|||http://purl.uniprot.org/uniprot/Q9X1U1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity).|||Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS02920 ^@ http://purl.uniprot.org/uniprot/Q9WYJ1|||http://purl.uniprot.org/uniprot/R4NXZ5 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Activity is insensitive to allosteric regulators L-valine and L-isoleucine at low concentrations, while these L-amino acids are inhibitors at high concentrations (PubMed:33938999). Is insensitive to ammonium chloride and AMP (PubMed:33938999). Inhibited in the presence of aminoxyacetic acid (AOAA), an inhibitor of pyridoxal phosphate-dependent enzymes (PubMed:33938999).|||Belongs to the serine/threonine dehydratase family.|||Catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia (PubMed:33938999). Can also use L-serine, but the catalytic efficiency toward L-threonine is about sixfold higher than that toward L-serine (PubMed:33938999). Shows also weak activity toward L-allo-threonine, but cannot use the corresponding D-amino acids (PubMed:33938999). Does not exhibit racemase activity toward various amino acids, including serine (PubMed:33938999). Physiologically, is likely involved in the threonine-dependent pathway of isoleucine biosynthesis (Probable).|||Homotetramer. http://togogenome.org/gene/243274:THEMA_RS01250 ^@ http://purl.uniprot.org/uniprot/Q9WZE9|||http://purl.uniprot.org/uniprot/R4P162 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS03720 ^@ http://purl.uniprot.org/uniprot/Q9WY40 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the TtcA family. TtuA subfamily.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe with a free coordination site may bind a small ligand, such as exogenous sulfide, thus acting as a sulfur carrier.|||Catalyzes the ATP-dependent 2-thiolation of 5-methyluridine residue at position 54 in the T loop of tRNAs, leading to 5-methyl-2-thiouridine (m(5)s(2)U or s(2)T) (PubMed:28655838). This modification allows thermal stabilization of tRNAs in thermophilic microorganisms, and is required for cell growth at high temperatures (By similarity). Can use free sulfide as sulfur source in vitro (PubMed:28655838).|||Homodimer.|||In TtuA from T.thermophilus, the sulfur inserted into the nucleoside comes from the C-terminal thiocarboxylate of TtuB, but there is no TtuB ortholog in T.maritima.|||The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster. http://togogenome.org/gene/243274:THEMA_RS04870 ^@ http://purl.uniprot.org/uniprot/Q9X2G7|||http://purl.uniprot.org/uniprot/R4NU81 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 130 family. http://togogenome.org/gene/243274:THEMA_RS02935 ^@ http://purl.uniprot.org/uniprot/Q9WYI8|||http://purl.uniprot.org/uniprot/R4NPZ8 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/243274:THEMA_RS01965 ^@ http://purl.uniprot.org/uniprot/Q9WZ12|||http://purl.uniprot.org/uniprot/R4NYF6 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/243274:THEMA_RS07410 ^@ http://purl.uniprot.org/uniprot/Q9X188|||http://purl.uniprot.org/uniprot/R4P0R3 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/243274:THEMA_RS01265 ^@ http://purl.uniprot.org/uniprot/G4FDE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FliN/MopA/SpaO family.|||Membrane http://togogenome.org/gene/243274:THEMA_RS00265 ^@ http://purl.uniprot.org/uniprot/Q9WZX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family. TsaB subfamily.|||Cytoplasm|||Homodimer (PubMed:20944216). Forms an hexamer composed of two TsaB, TsaD and TsaE trimers (PubMed:29741707).|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaE; this reaction does not require ATP in vitro. TsaB seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity). http://togogenome.org/gene/243274:THEMA_RS07975 ^@ http://purl.uniprot.org/uniprot/Q9X0Y3|||http://purl.uniprot.org/uniprot/R4NQZ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS00225 ^@ http://purl.uniprot.org/uniprot/Q9WZY4 ^@ Function|||Similarity ^@ Belongs to the trans-sulfuration enzymes family.|||Catalyzes the production of homocysteine from O-acetylhomoserine (OAH) and hydrogen sulfide (H2S), a step in the methionine biosynthesis pathway. Is not able to form cystathionine from O-acetylhomoserine and L-cysteine. http://togogenome.org/gene/243274:THEMA_RS00485 ^@ http://purl.uniprot.org/uniprot/G4FCZ3|||http://purl.uniprot.org/uniprot/P74921 ^@ Function|||Similarity ^@ Acts on leucine, isoleucine and valine.|||Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/243274:THEMA_RS00985 ^@ http://purl.uniprot.org/uniprot/G4FD89|||http://purl.uniprot.org/uniprot/Q9WZJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmG family. TrmFO subfamily.|||Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS03020 ^@ http://purl.uniprot.org/uniprot/Q9WYH1 ^@ Activity Regulation|||Biotechnology|||Function|||Similarity|||Subunit ^@ Belongs to the AB hydrolase superfamily. Esterase 10 family.|||Exhibits significant esterase activity with a preference for short acyl chain esters (C4-C8) in vitro. Its physiological function is not known. Displays neither proteolytic activity using casein as substrate, nor peptidase activity when assayed with L-leucine p-nitroanilide and L-proline p-nitroanilide.|||Exists mainly as a monomer and, to some extent as a dimer.|||Is strongly inhibited by phenylmethylsulfonyl fluoride, a serine protease inhibitor, and by mercury chloride. Diethyl pyrocarbonate, a histidine modifier, also inhibits the reaction, albeit less pronounced than phenylmethylsulfonyl fluoride. EDTA and dithiothreitol have no effect on enzyme activity.|||The high thermal stability and activity in the presence of organic solvents makes EstD an attractive catalyst for future applications in industry. http://togogenome.org/gene/243274:THEMA_RS03955 ^@ http://purl.uniprot.org/uniprot/Q9WY08|||http://purl.uniprot.org/uniprot/R4NMX3 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/243274:THEMA_RS06910 ^@ http://purl.uniprot.org/uniprot/G4FFJ9|||http://purl.uniprot.org/uniprot/P58288 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/243274:THEMA_RS03345 ^@ http://purl.uniprot.org/uniprot/Q9WYA9|||http://purl.uniprot.org/uniprot/R4NPS5 ^@ Similarity ^@ Belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/243274:THEMA_RS06675 ^@ http://purl.uniprot.org/uniprot/G4FFP6|||http://purl.uniprot.org/uniprot/Q9X1J7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endoribonuclease YbeY family.|||Binds 1 zinc ion.|||Cytoplasm|||Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. http://togogenome.org/gene/243274:THEMA_RS05870 ^@ http://purl.uniprot.org/uniprot/G4FG50|||http://purl.uniprot.org/uniprot/P96113 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/243274:THEMA_RS04140 ^@ http://purl.uniprot.org/uniprot/Q9WXX8 ^@ Function|||Similarity ^@ Belongs to the ABC transporter superfamily.|||Part of an ATP-driven transport system TM_0123/TM_0124/TM_0125 for a metal. Probably responsible for energy coupling to the transport system. http://togogenome.org/gene/243274:THEMA_RS07110 ^@ http://purl.uniprot.org/uniprot/O52681 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster.|||Catalyzes the oxidation of the physiological electron carriers NADH and reduced ferredoxin, coupled to the production of H(2) (PubMed:19411328). Acts as a bifurcating [FeFe] hydrogenase, which uses the exergonic oxidation of reduced ferredoxin to drive the unfavorable oxidation of NADH to produce H(2) (PubMed:19411328). The gamma subunit might be the site where reduced ferredoxin is oxidized (PubMed:19411328).|||Cytoplasm|||Heterotrimer composed of HydA (alpha subunit), HydB (beta subunit) and HydC (gamma subunit) (PubMed:10482784). Near neutral and acidic pH conditions favor oligomerization of the heterotrimeric holoenzyme (PubMed:10482784). http://togogenome.org/gene/243274:THEMA_RS04170 ^@ http://purl.uniprot.org/uniprot/G4FH33|||http://purl.uniprot.org/uniprot/Q7DFA2 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase class-2 family.|||Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. http://togogenome.org/gene/243274:THEMA_RS05970 ^@ http://purl.uniprot.org/uniprot/G4FG30|||http://purl.uniprot.org/uniprot/Q60034 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dihydrofolate reductase family.|||Homodimer.|||Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). http://togogenome.org/gene/243274:THEMA_RS01725 ^@ http://purl.uniprot.org/uniprot/Q9WZ57|||http://purl.uniprot.org/uniprot/R4NQM0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers. http://togogenome.org/gene/243274:THEMA_RS02705 ^@ http://purl.uniprot.org/uniprot/G4FHW0|||http://purl.uniprot.org/uniprot/Q9WYN2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidine kinase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/243274:THEMA_RS00890 ^@ http://purl.uniprot.org/uniprot/Q9WZL1|||http://purl.uniprot.org/uniprot/R4P1E7 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 4 family.|||Binds 1 NAD(+) per subunit. http://togogenome.org/gene/243274:THEMA_RS07985 ^@ http://purl.uniprot.org/uniprot/Q9X0Y1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||Displays high phosphatase activity toward erythrose 4-phosphate, fructose 6-phosphate, 2-deoxyglucose 6-phosphate, and mannose 6-phosphate. May have a role in the intracellular metabolism of many phosphorylated carbohydrates.|||Divalent metal cation. Highest activity with Co(2+), followed by Mg(2+), Mn(2+) or Ni(2+). http://togogenome.org/gene/243274:THEMA_RS07160 ^@ http://purl.uniprot.org/uniprot/O33832 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Belongs to the inositol monophosphatase superfamily. FBPase class 4 family.|||Homotetramer.|||In contrast to mammalian I-1-P phosphatases, is only weakly inhibited by Li(+), since 50% inhibitory concentration for Li(+) is about 100 mM, and the Li(+) concentration required to totally abolish I-1-Pase activity is 1 M.|||Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate, both D and L isomers of inositol-1-phosphate (I-1-P) but displaying a 20-fold higher rate of hydrolysis of D-I-1-P than of the L isomer, 2'-AMP, pNPP, inositol-2-phosphate, beta-glycerol phosphate, and alpha-D-glucose-1-phosphate. Cannot hydrolyze glucose-6-phosphate, fructose-6-phosphate, 5'-AMP and NAD(+). May be involved in the biosynthesis of a unique osmolyte, di-myo-inositol 1,1-phosphate. http://togogenome.org/gene/243274:THEMA_RS06875 ^@ http://purl.uniprot.org/uniprot/G4FFK6 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/243274:THEMA_RS08815 ^@ http://purl.uniprot.org/uniprot/G4FEQ7|||http://purl.uniprot.org/uniprot/Q9X0H5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS09490 ^@ http://purl.uniprot.org/uniprot/Q9X050|||http://purl.uniprot.org/uniprot/R4NZV2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS02010 ^@ http://purl.uniprot.org/uniprot/Q9WZ03|||http://purl.uniprot.org/uniprot/R4NNX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS07395 ^@ http://purl.uniprot.org/uniprot/G4FFA7|||http://purl.uniprot.org/uniprot/Q9X191 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.|||Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. http://togogenome.org/gene/243274:THEMA_RS05260 ^@ http://purl.uniprot.org/uniprot/G4FGG7|||http://purl.uniprot.org/uniprot/Q9X2A1 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/243274:THEMA_RS06555 ^@ http://purl.uniprot.org/uniprot/Q9X1L7|||http://purl.uniprot.org/uniprot/R4P3F4 ^@ Cofactor|||Similarity ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer. http://togogenome.org/gene/243274:THEMA_RS08200 ^@ http://purl.uniprot.org/uniprot/Q9X0T7|||http://purl.uniprot.org/uniprot/R4NSD0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS06660 ^@ http://purl.uniprot.org/uniprot/Q9X1K0|||http://purl.uniprot.org/uniprot/R4P150 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Cytoplasm|||Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. http://togogenome.org/gene/243274:THEMA_RS06030 ^@ http://purl.uniprot.org/uniprot/G4FG18|||http://purl.uniprot.org/uniprot/Q9X1W4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.|||Cytoplasm|||Homotrimer.|||In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/243274:THEMA_RS08295 ^@ http://purl.uniprot.org/uniprot/G4FEF5|||http://purl.uniprot.org/uniprot/O33836 ^@ Cofactor|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/243274:THEMA_RS00270 ^@ http://purl.uniprot.org/uniprot/G4FCV2 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/243274:THEMA_RS00475 ^@ http://purl.uniprot.org/uniprot/G4FCZ1|||http://purl.uniprot.org/uniprot/P77993 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/243274:THEMA_RS00420 ^@ http://purl.uniprot.org/uniprot/G4FCY0|||http://purl.uniprot.org/uniprot/Q9WZU8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase RlmH family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. http://togogenome.org/gene/243274:THEMA_RS09470 ^@ http://purl.uniprot.org/uniprot/G4FF31|||http://purl.uniprot.org/uniprot/Q9X054 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbsD / FucU family. RbsD subfamily.|||Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.|||Cytoplasm|||Homodecamer. http://togogenome.org/gene/243274:THEMA_RS07100 ^@ http://purl.uniprot.org/uniprot/O52683 ^@ Cofactor|||Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the oxidation of the physiological electron carriers NADH and reduced ferredoxin, coupled to the production of H(2) (PubMed:19411328). Acts as a bifurcating [FeFe] hydrogenase, which uses the exergonic oxidation of reduced ferredoxin to drive the unfavorable oxidation of NADH to produce H(2) (PubMed:19411328). The alpha subunit contains the catalytic H-cluster (PubMed:19411328).|||Contains a catalytic Fe binuclear center (H-cluster), which is coordinated by Cys-486 and by non-protein ligands.|||Cytoplasm|||Heterotrimer composed of HydA (alpha subunit), HydB (beta subunit) and HydC (gamma subunit) (PubMed:10482784). Near neutral and acidic pH conditions favor oligomerization of the heterotrimeric holoenzyme (PubMed:10482784).|||May bind 2 [2Fe-2S] clusters per subunit.|||May bind 4 [4Fe-4S] clusters per subunit. http://togogenome.org/gene/243274:THEMA_RS05980 ^@ http://purl.uniprot.org/uniprot/G4FG28 ^@ Cofactor ^@ Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/243274:THEMA_RS07670 ^@ http://purl.uniprot.org/uniprot/G4FI08 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS05170 ^@ http://purl.uniprot.org/uniprot/G4FGI4|||http://purl.uniprot.org/uniprot/Q9X2B6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Involved in the integration of spacer DNA into the CRISPR cassette (By similarity). Functions as a ssRNA-specific endoribonuclease.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/243274:THEMA_RS01390 ^@ http://purl.uniprot.org/uniprot/G4FDG9|||http://purl.uniprot.org/uniprot/Q9WZC3 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.|||Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain (Probable).|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain. http://togogenome.org/gene/243274:THEMA_RS04760 ^@ http://purl.uniprot.org/uniprot/Q9X2I7|||http://purl.uniprot.org/uniprot/R4P4E9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/243274:THEMA_RS02860 ^@ http://purl.uniprot.org/uniprot/Q9WYK2|||http://purl.uniprot.org/uniprot/R4NQ09 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS08195 ^@ http://purl.uniprot.org/uniprot/Q9X0T8|||http://purl.uniprot.org/uniprot/R4P0L6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/243274:THEMA_RS06760 ^@ http://purl.uniprot.org/uniprot/G4FFM9|||http://purl.uniprot.org/uniprot/P38514 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/243274:THEMA_RS01325 ^@ http://purl.uniprot.org/uniprot/Q9WZD6|||http://purl.uniprot.org/uniprot/R4P146 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/243274:THEMA_RS07255 ^@ http://purl.uniprot.org/uniprot/G4FFD2|||http://purl.uniprot.org/uniprot/Q9X1B6 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS05275 ^@ http://purl.uniprot.org/uniprot/Q9X298|||http://purl.uniprot.org/uniprot/R4NU08 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/243274:THEMA_RS03935 ^@ http://purl.uniprot.org/uniprot/G4FH79|||http://purl.uniprot.org/uniprot/Q9WY12 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvA family.|||Cytoplasm|||Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.|||Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA (By similarity). Promotes Holliday junction (HJ) branch migration in conjunction with RuvB (PubMed:11478862).|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/243274:THEMA_RS04415 ^@ http://purl.uniprot.org/uniprot/G4FGY4|||http://purl.uniprot.org/uniprot/Q9WXS4 ^@ Function|||Similarity ^@ Belongs to the mannonate dehydratase family.|||Catalyzes the dehydration of D-mannonate. http://togogenome.org/gene/243274:THEMA_RS01870 ^@ http://purl.uniprot.org/uniprot/G4FDR0|||http://purl.uniprot.org/uniprot/Q9WZ31 ^@ Activity Regulation|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Cell inner membrane|||Homopentamer (PubMed:22722933, PubMed:23781956, PubMed:16902408, PubMed:16598263, PubMed:16857941, PubMed:23112165, PubMed:23425532, PubMed:26871634). In the absence of Mg(2+), interactions between subunits are weakened, and dimers, trimers and tetramers can be observed in vitro (PubMed:22722933, PubMed:26871634).|||Inhibited by cobalt hexaammine.|||Mediates influx of magnesium ions (PubMed:18276588, PubMed:22722933, PubMed:23781956, PubMed:23112165). Mediates Co(2+) uptake (PubMed:21454699, PubMed:23091000, PubMed:23425532). Has high selectivity for Co(2+) (PubMed:21454699, PubMed:23425532). Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high (PubMed:23112165, PubMed:23425532, PubMed:26871634).|||Mediates influx of magnesium ions.|||Membrane|||The central ion permeation pathway is formed by the first transmembrane domain from each of the five subunits. Mg(2+) binding strengthens interactions between subunits and leads to the formation of a symmetrical homopentamer surrounding a closed ion permeation pathway (PubMed:23091000, PubMed:16902408, PubMed:16598263, PubMed:16857941, PubMed:23112165, PubMed:23425532, PubMed:26871634). Co(2+) binding also induces a conformation change (PubMed:21454699). Low Mg(2+) concentrations trigger both a conformation change within each subunit and a loosening of the interactions between subunits. This results in an open ion conduction pathway. In addition, this results in a less symmetrical shape of the whole complex (PubMed:23112165, PubMed:26871634). http://togogenome.org/gene/243274:THEMA_RS04680 ^@ http://purl.uniprot.org/uniprot/Q56316 ^@ Cofactor|||Subunit ^@ Binds 2 [4Fe-4S] clusters.|||Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/243274:THEMA_RS08225 ^@ http://purl.uniprot.org/uniprot/Q9X0T2|||http://purl.uniprot.org/uniprot/R4NSC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.|||Cell membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS04090 ^@ http://purl.uniprot.org/uniprot/Q9WXY8|||http://purl.uniprot.org/uniprot/R4NXC0 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/243274:THEMA_RS03025 ^@ http://purl.uniprot.org/uniprot/Q9WYH0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. http://togogenome.org/gene/243274:THEMA_RS09735 ^@ http://purl.uniprot.org/uniprot/Q9S5X8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 12 (cellulase H) family. http://togogenome.org/gene/243274:THEMA_RS07980 ^@ http://purl.uniprot.org/uniprot/G4FE93|||http://purl.uniprot.org/uniprot/Q9X0Y2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS01810 ^@ http://purl.uniprot.org/uniprot/Q9WZ42|||http://purl.uniprot.org/uniprot/R4NP16 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/243274:THEMA_RS03805 ^@ http://purl.uniprot.org/uniprot/Q9WY30 ^@ Activity Regulation|||Function ^@ Can function in vivo with either divalent iron or manganese occupying di- and trimetal sites. Dimetal is necessary and sufficient to catalyze conversion of c-di-GMP to pGpG, but conversion of pGpG to GMP requires an occupied trimetal site.|||Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP) to GMP. Hydrolyzes c-di-GMP to GMP in a two-step reaction, via the linear intermediate 5'-phosphoguanylyl(3'->5')guanosine (pGpG). http://togogenome.org/gene/243274:THEMA_RS03475 ^@ http://purl.uniprot.org/uniprot/Q9WY88|||http://purl.uniprot.org/uniprot/R4NN82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RnfG family.|||Cell inner membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/243274:THEMA_RS03160 ^@ http://purl.uniprot.org/uniprot/G4FHM3 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 5 family. http://togogenome.org/gene/243274:THEMA_RS05105 ^@ http://purl.uniprot.org/uniprot/Q9X2C9|||http://purl.uniprot.org/uniprot/R4P207 ^@ Similarity ^@ Belongs to the CRISPR-associated Csm3 family. http://togogenome.org/gene/243274:THEMA_RS00835 ^@ http://purl.uniprot.org/uniprot/G4FD60|||http://purl.uniprot.org/uniprot/Q9WZM2 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/243274:THEMA_RS01900 ^@ http://purl.uniprot.org/uniprot/Q9WZ25 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/243274:THEMA_RS00885 ^@ http://purl.uniprot.org/uniprot/G4FD70 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). http://togogenome.org/gene/243274:THEMA_RS05290 ^@ http://purl.uniprot.org/uniprot/G4FGG1|||http://purl.uniprot.org/uniprot/Q9X295 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/243274:THEMA_RS03920 ^@ http://purl.uniprot.org/uniprot/G4FH82|||http://purl.uniprot.org/uniprot/Q9WY15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/243274:THEMA_RS03085 ^@ http://purl.uniprot.org/uniprot/Q9WYF9|||http://purl.uniprot.org/uniprot/R4NY85 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS07675 ^@ http://purl.uniprot.org/uniprot/Q9X143|||http://purl.uniprot.org/uniprot/R4P2X6 ^@ Similarity ^@ Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. http://togogenome.org/gene/243274:THEMA_RS06695 ^@ http://purl.uniprot.org/uniprot/G4FFP2|||http://purl.uniprot.org/uniprot/Q9X1J3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/243274:THEMA_RS00710 ^@ http://purl.uniprot.org/uniprot/G4FD36|||http://purl.uniprot.org/uniprot/Q9WZP5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. http://togogenome.org/gene/243274:THEMA_RS05910 ^@ http://purl.uniprot.org/uniprot/Q9S5X9|||http://purl.uniprot.org/uniprot/R4NTL2 ^@ Similarity|||Subunit ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS02290 ^@ http://purl.uniprot.org/uniprot/G4FDZ0|||http://purl.uniprot.org/uniprot/Q9WYV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/243274:THEMA_RS04525 ^@ http://purl.uniprot.org/uniprot/Q9WXQ4|||http://purl.uniprot.org/uniprot/R4NMK5 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/243274:THEMA_RS03165 ^@ http://purl.uniprot.org/uniprot/Q9WYE4|||http://purl.uniprot.org/uniprot/R4NY73 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/243274:THEMA_RS03580 ^@ http://purl.uniprot.org/uniprot/G4FHD9|||http://purl.uniprot.org/uniprot/Q9WY68 ^@ Similarity ^@ Belongs to the ACC deaminase/D-cysteine desulfhydrase family. http://togogenome.org/gene/243274:THEMA_RS03815 ^@ http://purl.uniprot.org/uniprot/G4FH98|||http://purl.uniprot.org/uniprot/Q9WY28 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/243274:THEMA_RS09360 ^@ http://purl.uniprot.org/uniprot/Q9X077|||http://purl.uniprot.org/uniprot/R4NQ70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsuA/YedE (TC 9.B.102) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/243274:THEMA_RS05245 ^@ http://purl.uniprot.org/uniprot/G4FGH0|||http://purl.uniprot.org/uniprot/Q9X2A3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Some bacteria possess a monofunctional ArgJ, i.e. capable of catalyzing only the fifth step of the arginine biosynthetic pathway.|||Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/243274:THEMA_RS00320 ^@ http://purl.uniprot.org/uniprot/G4FCW1|||http://purl.uniprot.org/uniprot/Q9WZW7 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/243274:THEMA_RS03985 ^@ http://purl.uniprot.org/uniprot/Q9WY03|||http://purl.uniprot.org/uniprot/R4NXE1 ^@ Cofactor|||Similarity ^@ Belongs to the alkaline phosphatase family.|||Binds 1 Mg(2+) ion.|||Binds 2 Zn(2+) ions. http://togogenome.org/gene/243274:THEMA_RS02305 ^@ http://purl.uniprot.org/uniprot/Q01969 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cell outer membrane|||Homotetramer.|||Links the outer membrane to the inner membrane. Long fibrous protein that could serve to separate the two membranes. http://togogenome.org/gene/243274:THEMA_RS05325 ^@ http://purl.uniprot.org/uniprot/G4FGF4|||http://purl.uniprot.org/uniprot/Q9X288 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/243274:THEMA_RS00695 ^@ http://purl.uniprot.org/uniprot/G4FD33|||http://purl.uniprot.org/uniprot/Q9WZP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).|||Cytoplasm