http://togogenome.org/gene/2585118:FMF02_RS08870 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WTM4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2585118:FMF02_RS11935 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WW26 ^@ Function|||Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.|||Homotetramer. http://togogenome.org/gene/2585118:FMF02_RS13395 ^@ http://purl.uniprot.org/uniprot/A0A3D3YQ57 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/2585118:FMF02_RS01870 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WQK1 ^@ Similarity ^@ Belongs to the ParB family. http://togogenome.org/gene/2585118:FMF02_RS08710 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XMA6 ^@ Similarity ^@ Belongs to the ATPase alpha/beta chains family. http://togogenome.org/gene/2585118:FMF02_RS02565 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XRC6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/2585118:FMF02_RS06125 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WUU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/2585118:FMF02_RS04280 ^@ http://purl.uniprot.org/uniprot/A0A3D3YLL1 ^@ Similarity ^@ Belongs to the Skp family. http://togogenome.org/gene/2585118:FMF02_RS07250 ^@ http://purl.uniprot.org/uniprot/A0A3D3YKM7 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/2585118:FMF02_RS08550 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WW39 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/2585118:FMF02_RS06975 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WUX8 ^@ Caution|||Function|||Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.|||Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2585118:FMF02_RS08285 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XKQ4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/2585118:FMF02_RS13370 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WWJ6 ^@ Similarity ^@ Belongs to the SufE family. http://togogenome.org/gene/2585118:FMF02_RS01550 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XT10 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2585118:FMF02_RS12410 ^@ http://purl.uniprot.org/uniprot/A0A3D3YLM0 ^@ Cofactor|||Similarity ^@ Belongs to the rubredoxin family.|||Binds 1 Fe(3+) ion per subunit. http://togogenome.org/gene/2585118:FMF02_RS05215 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XRC5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/2585118:FMF02_RS03525 ^@ http://purl.uniprot.org/uniprot/A0A3D3YSC0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/2585118:FMF02_RS10430 ^@ http://purl.uniprot.org/uniprot/A0A3D3YM52 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/2585118:FMF02_RS12035 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WW53 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/2585118:FMF02_RS13175 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XN05 ^@ Cofactor|||Similarity ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer. http://togogenome.org/gene/2585118:FMF02_RS05155 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WTV7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2585118:FMF02_RS08985 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WTM9 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/2585118:FMF02_RS03900 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WQT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase Y family.|||Cell membrane|||Endoribonuclease that initiates mRNA decay. http://togogenome.org/gene/2585118:FMF02_RS08630 ^@ http://purl.uniprot.org/uniprot/A0A3D3YRH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/2585118:FMF02_RS07730 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WSZ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I fumarase family.|||Catalyzes the reversible hydration of fumarate to (S)-malate.|||Homodimer. http://togogenome.org/gene/2585118:FMF02_RS12605 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WY54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/2585118:FMF02_RS13500 ^@ http://purl.uniprot.org/uniprot/A0A3D3YNI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Membrane http://togogenome.org/gene/2585118:FMF02_RS07135 ^@ http://purl.uniprot.org/uniprot/A0A3D3YJ22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2585118:FMF02_RS01270 ^@ http://purl.uniprot.org/uniprot/A0A3D2BB76 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/2585118:FMF02_RS10650 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WUV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2585118:FMF02_RS00950 ^@ http://purl.uniprot.org/uniprot/A0A3D3YNI3 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/2585118:FMF02_RS10045 ^@ http://purl.uniprot.org/uniprot/A0A3D3YNJ5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/2585118:FMF02_RS04860 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WRE5 ^@ Function ^@ Abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes. http://togogenome.org/gene/2585118:FMF02_RS01300 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WPU3 ^@ Cofactor|||Similarity ^@ Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.|||Binds 3 [4Fe-4S] clusters per subunit. http://togogenome.org/gene/2585118:FMF02_RS04585 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WTW6 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGMT family.|||Cytoplasm|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.|||This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. http://togogenome.org/gene/2585118:FMF02_RS07475 ^@ http://purl.uniprot.org/uniprot/A0A3D3YMP1 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/2585118:FMF02_RS11750 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XMF6 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/2585118:FMF02_RS12385 ^@ http://purl.uniprot.org/uniprot/A0A3D3YNI4 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion per subunit.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.|||In the C-terminal section; belongs to the GTP cyclohydrolase II family.|||In the N-terminal section; belongs to the DHBP synthase family. http://togogenome.org/gene/2585118:FMF02_RS13145 ^@ http://purl.uniprot.org/uniprot/A0A3D3YM96 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/2585118:FMF02_RS10780 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WV63 ^@ Similarity ^@ Belongs to the NusB family. http://togogenome.org/gene/2585118:FMF02_RS10850 ^@ http://purl.uniprot.org/uniprot/A0A3D3YLV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2585118:FMF02_RS01950 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WPN3 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/2585118:FMF02_RS08505 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WW33 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/2585118:FMF02_RS07620 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WVM3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2585118:FMF02_RS03545 ^@ http://purl.uniprot.org/uniprot/A0A3D3YQJ0 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/2585118:FMF02_RS05615 ^@ http://purl.uniprot.org/uniprot/A0A3D3YMD1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Binds 1 pyridoxal phosphate per subunit.|||Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2585118:FMF02_RS06725 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WT24 ^@ Similarity ^@ Belongs to the RecJ family. http://togogenome.org/gene/2585118:FMF02_RS01205 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WP87 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.|||Binds 3 [4Fe-4S] clusters.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/2585118:FMF02_RS05665 ^@ http://purl.uniprot.org/uniprot/A0A3D3YPH5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/2585118:FMF02_RS04225 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XSE6 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/2585118:FMF02_RS01110 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WQV2 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2585118:FMF02_RS05150 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WUB9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/2585118:FMF02_RS06710 ^@ http://purl.uniprot.org/uniprot/A0A3D2BGV5 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family. http://togogenome.org/gene/2585118:FMF02_RS06500 ^@ http://purl.uniprot.org/uniprot/A0A3D2BEG7 ^@ Similarity ^@ Belongs to the XseB family. http://togogenome.org/gene/2585118:FMF02_RS01070 ^@ http://purl.uniprot.org/uniprot/A0A3D3YNU9 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/2585118:FMF02_RS11180 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WXQ1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the BPG-independent phosphoglycerate mutase family.|||Binds 2 manganese ions per subunit.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.|||Monomer. http://togogenome.org/gene/2585118:FMF02_RS10920 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WUS1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/2585118:FMF02_RS00940 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WS36 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2585118:FMF02_RS04685 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WRT6 ^@ Similarity ^@ Belongs to the bacterial reverse transcriptase family. http://togogenome.org/gene/2585118:FMF02_RS09365 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WW75 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/2585118:FMF02_RS03515 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XUA1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/2585118:FMF02_RS05540 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WTG3 ^@ Similarity ^@ Belongs to the DprA/Smf family. http://togogenome.org/gene/2585118:FMF02_RS09675 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WUK8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.|||Cell membrane|||Mediates zinc uptake. May also transport other divalent cations.|||Membrane http://togogenome.org/gene/2585118:FMF02_RS05675 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WRV6 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/2585118:FMF02_RS03865 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WSC7 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/2585118:FMF02_RS02290 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WRG6 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/2585118:FMF02_RS06985 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WVB0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2585118:FMF02_RS05185 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WSK9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/2585118:FMF02_RS05140 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WU61 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/2585118:FMF02_RS05175 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WRK2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2585118:FMF02_RS02340 ^@ http://purl.uniprot.org/uniprot/A0A3D3YQJ9 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/2585118:FMF02_RS09985 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WUB5 ^@ Similarity ^@ Belongs to the fabD family. http://togogenome.org/gene/2585118:FMF02_RS10055 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WW49 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/2585118:FMF02_RS03940 ^@ http://purl.uniprot.org/uniprot/A0A3D3YLF0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/2585118:FMF02_RS08200 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XP20 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2585118:FMF02_RS04260 ^@ http://purl.uniprot.org/uniprot/A0A3D3YN00 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2585118:FMF02_RS10225 ^@ http://purl.uniprot.org/uniprot/A0A3D3YN24 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/2585118:FMF02_RS08715 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XKS6 ^@ Similarity ^@ Belongs to the V-ATPase D subunit family. http://togogenome.org/gene/2585118:FMF02_RS08960 ^@ http://purl.uniprot.org/uniprot/A0A3D3YP35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LpxC family.|||Belongs to the thioester dehydratase family. FabZ subfamily.|||Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.|||Cytoplasm|||Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. http://togogenome.org/gene/2585118:FMF02_RS00965 ^@ http://purl.uniprot.org/uniprot/A0A3D3YLC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MgtC/SapB family.|||Membrane http://togogenome.org/gene/2585118:FMF02_RS03820 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WTG4 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/2585118:FMF02_RS13450 ^@ http://purl.uniprot.org/uniprot/A0A3D3YM20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Cytoplasm|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. http://togogenome.org/gene/2585118:FMF02_RS01515 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WQM6 ^@ Similarity ^@ Belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/2585118:FMF02_RS11205 ^@ http://purl.uniprot.org/uniprot/A0A3D3YMC4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NqrA family.|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. http://togogenome.org/gene/2585118:FMF02_RS05135 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XS27 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/2585118:FMF02_RS05195 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WSA2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/2585118:FMF02_RS02890 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WQ84 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/2585118:FMF02_RS07675 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WSZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/2585118:FMF02_RS08415 ^@ http://purl.uniprot.org/uniprot/A0A3D3YJW8 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/2585118:FMF02_RS09980 ^@ http://purl.uniprot.org/uniprot/A0A3D2BCQ8 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/2585118:FMF02_RS08660 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WTI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/2585118:FMF02_RS04480 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WS80 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/2585118:FMF02_RS05085 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WSI8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/2585118:FMF02_RS02385 ^@ http://purl.uniprot.org/uniprot/A0A3D3YQS4 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/2585118:FMF02_RS10595 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XNE7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/2585118:FMF02_RS09165 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WW42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/2585118:FMF02_RS05090 ^@ http://purl.uniprot.org/uniprot/A0A3D3YQ02 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/2585118:FMF02_RS11870 ^@ http://purl.uniprot.org/uniprot/A0A3D3YLM5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2585118:FMF02_RS03435 ^@ http://purl.uniprot.org/uniprot/A0A3D3YPN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.|||Cell membrane http://togogenome.org/gene/2585118:FMF02_RS01200 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WPS2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.|||Binds 2 [4Fe-4S] clusters per subunit.|||Cell membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/2585118:FMF02_RS04055 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WR00 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/2585118:FMF02_RS10905 ^@ http://purl.uniprot.org/uniprot/A0A3D3YNZ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/2585118:FMF02_RS11970 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WXQ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA. http://togogenome.org/gene/2585118:FMF02_RS12245 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WX96 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/2585118:FMF02_RS05225 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WRL2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/2585118:FMF02_RS12315 ^@ http://purl.uniprot.org/uniprot/A0A3D3YLN3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/2585118:FMF02_RS09875 ^@ http://purl.uniprot.org/uniprot/A0A3D2BEZ4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/2585118:FMF02_RS05690 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WTJ9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endoribonuclease YbeY family.|||Binds 1 zinc ion.|||Cytoplasm|||Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. http://togogenome.org/gene/2585118:FMF02_RS07170 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WTS3 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/2585118:FMF02_RS02840 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WQ75 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A monovalent cation. Ammonium or potassium.|||Belongs to the type III pantothenate kinase family.|||Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2585118:FMF02_RS03560 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XS20 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/2585118:FMF02_RS03935 ^@ http://purl.uniprot.org/uniprot/A0A3D2BFA2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/2585118:FMF02_RS05105 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WTU7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/2585118:FMF02_RS08280 ^@ http://purl.uniprot.org/uniprot/A0A3D2BD17 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/2585118:FMF02_RS05740 ^@ http://purl.uniprot.org/uniprot/A0A3D3YQ37 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/2585118:FMF02_RS05380 ^@ http://purl.uniprot.org/uniprot/A0A3D3YL41 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2585118:FMF02_RS05205 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WTW8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2585118:FMF02_RS00995 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WP41 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/2585118:FMF02_RS06705 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WSE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0324 family.|||Membrane http://togogenome.org/gene/2585118:FMF02_RS02855 ^@ http://purl.uniprot.org/uniprot/A0A3D2BDF5 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/2585118:FMF02_RS07195 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XL45 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2585118:FMF02_RS05075 ^@ http://purl.uniprot.org/uniprot/A0A3D3YR00 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/2585118:FMF02_RS04010 ^@ http://purl.uniprot.org/uniprot/A0A3D2BF70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm|||Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. http://togogenome.org/gene/2585118:FMF02_RS13130 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WXQ7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2585118:FMF02_RS10560 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XLT2 ^@ Function|||Similarity ^@ Belongs to the bacterioferritin family.|||Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex. http://togogenome.org/gene/2585118:FMF02_RS03875 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XQA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.|||Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.|||Cell membrane http://togogenome.org/gene/2585118:FMF02_RS03700 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XRM7 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/2585118:FMF02_RS08925 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WTN4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/2585118:FMF02_RS07230 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XL61 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). http://togogenome.org/gene/2585118:FMF02_RS02800 ^@ http://purl.uniprot.org/uniprot/A0A3D3YMZ7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/2585118:FMF02_RS02865 ^@ http://purl.uniprot.org/uniprot/A0A3D2BDF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsaE family.|||Cytoplasm http://togogenome.org/gene/2585118:FMF02_RS08370 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WTB8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2585118:FMF02_RS09700 ^@ http://purl.uniprot.org/uniprot/A0A3D3YM28 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the adenylate cyclase family. DacA/CdaA subfamily.|||Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Probably a homodimer. http://togogenome.org/gene/2585118:FMF02_RS13530 ^@ http://purl.uniprot.org/uniprot/A0A3D3YRN4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2585118:FMF02_RS06390 ^@ http://purl.uniprot.org/uniprot/A0A3D3YJM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.|||Membrane http://togogenome.org/gene/2585118:FMF02_RS05190 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XVP4 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/2585118:FMF02_RS06495 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WSC6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseA family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/2585118:FMF02_RS10040 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WUC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsY family.|||Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.|||Cell membrane|||Probably interacts with PlsX. http://togogenome.org/gene/2585118:FMF02_RS05765 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WUB7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. http://togogenome.org/gene/2585118:FMF02_RS13190 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XPR5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/2585118:FMF02_RS01065 ^@ http://purl.uniprot.org/uniprot/A0A3D2BEG4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF2.|||Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. http://togogenome.org/gene/2585118:FMF02_RS04610 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XUZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/2585118:FMF02_RS07085 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WVC5 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/2585118:FMF02_RS04470 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WR77 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerC subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/2585118:FMF02_RS12380 ^@ http://purl.uniprot.org/uniprot/A0A3D3YNS3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2585118:FMF02_RS01420 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WS49 ^@ Similarity ^@ Belongs to the UPF0758 family. http://togogenome.org/gene/2585118:FMF02_RS04160 ^@ http://purl.uniprot.org/uniprot/A0A3D2BEY0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers. http://togogenome.org/gene/2585118:FMF02_RS09795 ^@ http://purl.uniprot.org/uniprot/A0A3D2BE61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane http://togogenome.org/gene/2585118:FMF02_RS08795 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XM14 ^@ Similarity ^@ Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. http://togogenome.org/gene/2585118:FMF02_RS06835 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WV78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/2585118:FMF02_RS09670 ^@ http://purl.uniprot.org/uniprot/A0A3D3YKA0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2585118:FMF02_RS03530 ^@ http://purl.uniprot.org/uniprot/A0A3D2BFB9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/2585118:FMF02_RS07930 ^@ http://purl.uniprot.org/uniprot/A0A3D3YL66 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/2585118:FMF02_RS09915 ^@ http://purl.uniprot.org/uniprot/A0A3D2BBB2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2585118:FMF02_RS05980 ^@ http://purl.uniprot.org/uniprot/A0A3D3YQ17 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidine kinase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/2585118:FMF02_RS06900 ^@ http://purl.uniprot.org/uniprot/A0A3D3YR85 ^@ Similarity ^@ Belongs to the ThrE exporter (TC 2.A.79) family. http://togogenome.org/gene/2585118:FMF02_RS05910 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WSP3 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. http://togogenome.org/gene/2585118:FMF02_RS11375 ^@ http://purl.uniprot.org/uniprot/A0A3D3YME4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2585118:FMF02_RS03840 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WT50 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL31 family. http://togogenome.org/gene/2585118:FMF02_RS12755 ^@ http://purl.uniprot.org/uniprot/A0A3D2BCK8 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. http://togogenome.org/gene/2585118:FMF02_RS05720 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WRW4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/2585118:FMF02_RS12730 ^@ http://purl.uniprot.org/uniprot/A0A3D3YKW3 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/2585118:FMF02_RS13135 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XN66 ^@ Function ^@ Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. http://togogenome.org/gene/2585118:FMF02_RS06610 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XIX2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2585118:FMF02_RS07795 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WUU3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ClpA/ClpB family.|||Cytoplasm|||Homohexamer. The oligomerization is ATP-dependent.|||Homohexamer; The oligomerization is ATP-dependent.|||Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. http://togogenome.org/gene/2585118:FMF02_RS01345 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WPA8 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/2585118:FMF02_RS11745 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WV79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uridine kinase family.|||Cytoplasm http://togogenome.org/gene/2585118:FMF02_RS12725 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WW29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/2585118:FMF02_RS05200 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WUC4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/2585118:FMF02_RS03350 ^@ http://purl.uniprot.org/uniprot/A0A3D3YN75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatA/E family.|||Cell membrane|||Forms a complex with TatC.|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. http://togogenome.org/gene/2585118:FMF02_RS02140 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WQ96 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/2585118:FMF02_RS04565 ^@ http://purl.uniprot.org/uniprot/A0A3D3YJ85 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatA/E family.|||Cell membrane|||Forms a complex with TatC.|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. http://togogenome.org/gene/2585118:FMF02_RS06085 ^@ http://purl.uniprot.org/uniprot/A0A3D2BEL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/2585118:FMF02_RS11550 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WXV5 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/2585118:FMF02_RS05180 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XT95 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/2585118:FMF02_RS05170 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WS31 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/2585118:FMF02_RS02300 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WSP1 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the peroxiredoxin family. Tpx subfamily.|||Homodimer.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/2585118:FMF02_RS06410 ^@ http://purl.uniprot.org/uniprot/A0A3D3YLF3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueA family.|||Cytoplasm|||Monomer.|||Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). http://togogenome.org/gene/2585118:FMF02_RS05125 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XRB2 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/2585118:FMF02_RS02590 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XPF5 ^@ Caution|||Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.|||Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2585118:FMF02_RS09025 ^@ http://purl.uniprot.org/uniprot/A0A3D3YM47 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/2585118:FMF02_RS12625 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WW00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/2585118:FMF02_RS11990 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XP76 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional regulatory Rex family.|||Cytoplasm|||Homodimer.|||Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. http://togogenome.org/gene/2585118:FMF02_RS04045 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WQW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/2585118:FMF02_RS01410 ^@ http://purl.uniprot.org/uniprot/A0A3D2BEU9 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/2585118:FMF02_RS13410 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WYH0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family.|||Homotrimer.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/2585118:FMF02_RS06690 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WSG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).|||Cytoplasm http://togogenome.org/gene/2585118:FMF02_RS08495 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WVU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm http://togogenome.org/gene/2585118:FMF02_RS09090 ^@ http://purl.uniprot.org/uniprot/A0A3D3YL06 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/2585118:FMF02_RS03535 ^@ http://purl.uniprot.org/uniprot/A0A3D2BFK1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/2585118:FMF02_RS08055 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XK18 ^@ Similarity ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. http://togogenome.org/gene/2585118:FMF02_RS05930 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WS06 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/2585118:FMF02_RS06775 ^@ http://purl.uniprot.org/uniprot/A0A3D3YQ52 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/2585118:FMF02_RS05255 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WUD0 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 130 family.|||Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man-Glc) to mannose 1-phosphate (Man1P) and glucose. http://togogenome.org/gene/2585118:FMF02_RS12800 ^@ http://purl.uniprot.org/uniprot/A0A3D3YQ43 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IspF family.|||Binds 1 divalent metal cation per subunit.|||Homotrimer.|||Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2585118:FMF02_RS09245 ^@ http://purl.uniprot.org/uniprot/A0A3D3YN03 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2585118:FMF02_RS01225 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XNS8 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/2585118:FMF02_RS10050 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WU86 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methylthiotransferase family. MiaB subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.|||Cytoplasm|||Monomer. http://togogenome.org/gene/2585118:FMF02_RS08080 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WV03 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/2585118:FMF02_RS05570 ^@ http://purl.uniprot.org/uniprot/A0A3D2BDM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/2585118:FMF02_RS00050 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WPT7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2585118:FMF02_RS05340 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WSQ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerC subfamily.|||Belongs to the 'phage' integrase family. XerD subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/2585118:FMF02_RS06140 ^@ http://purl.uniprot.org/uniprot/A0A3D3YK97 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/2585118:FMF02_RS00865 ^@ http://purl.uniprot.org/uniprot/A0A3D2BF13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KdsA family.|||Cytoplasm http://togogenome.org/gene/2585118:FMF02_RS04015 ^@ http://purl.uniprot.org/uniprot/A0A3D3YJA9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/2585118:FMF02_RS08315 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XM15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/2585118:FMF02_RS07670 ^@ http://purl.uniprot.org/uniprot/A0A3D2BDC1 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/2585118:FMF02_RS08970 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WTP4 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/2585118:FMF02_RS06620 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WUR9 ^@ Similarity|||Subunit ^@ Belongs to the KdsC family.|||Homotetramer. http://togogenome.org/gene/2585118:FMF02_RS05080 ^@ http://purl.uniprot.org/uniprot/A0A3D3YPK0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/2585118:FMF02_RS00900 ^@ http://purl.uniprot.org/uniprot/A0A3D3YPH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/2585118:FMF02_RS05925 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WS13 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/2585118:FMF02_RS11940 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WVB7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2585118:FMF02_RS03330 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WQH6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/2585118:FMF02_RS07710 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XJH9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.|||Binds 1 Mn(2+) ion per subunit.|||Cytoplasm|||Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. http://togogenome.org/gene/2585118:FMF02_RS03920 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WRX4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Membrane|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/2585118:FMF02_RS05010 ^@ http://purl.uniprot.org/uniprot/A0A3D3YMZ6 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/2585118:FMF02_RS09695 ^@ http://purl.uniprot.org/uniprot/A0A3D2BBA2 ^@ Similarity ^@ Belongs to the Skp family. http://togogenome.org/gene/2585118:FMF02_RS07640 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WTM8 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. http://togogenome.org/gene/2585118:FMF02_RS00820 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WQP4 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/2585118:FMF02_RS09250 ^@ http://purl.uniprot.org/uniprot/A0A3D2BFH4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 1 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/2585118:FMF02_RS06180 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XRS9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2585118:FMF02_RS06810 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WSG1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family. YhdE subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/2585118:FMF02_RS03540 ^@ http://purl.uniprot.org/uniprot/A0A3D2BFF1 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/2585118:FMF02_RS10210 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WVF9 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/2585118:FMF02_RS07665 ^@ http://purl.uniprot.org/uniprot/A0A3D3YP25 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/2585118:FMF02_RS09150 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WW56 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/2585118:FMF02_RS05130 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WT85 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/2585118:FMF02_RS05070 ^@ http://purl.uniprot.org/uniprot/A0A3D3YR76 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/2585118:FMF02_RS00810 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WPJ5 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2585118:FMF02_RS02390 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WQV0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2585118:FMF02_RS06905 ^@ http://purl.uniprot.org/uniprot/A0A3D2BBM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ThrE exporter (TC 2.A.79) family.|||Membrane http://togogenome.org/gene/2585118:FMF02_RS02455 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WPZ2 ^@ Cofactor ^@ Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/2585118:FMF02_RS00855 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WP06 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/2585118:FMF02_RS13205 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WYD4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/2585118:FMF02_RS09035 ^@ http://purl.uniprot.org/uniprot/A0A3D2BIM1 ^@ Similarity ^@ Belongs to the acetyl-CoA hydrolase/transferase family. http://togogenome.org/gene/2585118:FMF02_RS09305 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WUF2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/2585118:FMF02_RS05145 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XRN3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/2585118:FMF02_RS03850 ^@ http://purl.uniprot.org/uniprot/A0A3D3YN50 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/2585118:FMF02_RS11330 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WVH3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KdpA family.|||Cell membrane|||Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.|||The system is composed of three essential subunits: KdpA, KdpB and KdpC. http://togogenome.org/gene/2585118:FMF02_RS01530 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WSF3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2585118:FMF02_RS11230 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WXQ9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrF family.|||Binds 1 [2Fe-2S] cluster.|||Cell membrane|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway. http://togogenome.org/gene/2585118:FMF02_RS01185 ^@ http://purl.uniprot.org/uniprot/A0A3D3YLS2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell membrane|||Membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/2585118:FMF02_RS02985 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WSP4 ^@ Similarity ^@ Belongs to the sigma-54 factor family. http://togogenome.org/gene/2585118:FMF02_RS08145 ^@ http://purl.uniprot.org/uniprot/A0A3D2BG52 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with bS18 to 16S ribosomal RNA. http://togogenome.org/gene/2585118:FMF02_RS00785 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WPX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/2585118:FMF02_RS12765 ^@ http://purl.uniprot.org/uniprot/A0A3D2BCB7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/2585118:FMF02_RS01435 ^@ http://purl.uniprot.org/uniprot/A0A3D3YJR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YqgF HJR family.|||Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.|||Cytoplasm http://togogenome.org/gene/2585118:FMF02_RS06400 ^@ http://purl.uniprot.org/uniprot/A0A3D3YJ24 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell membrane|||Membrane http://togogenome.org/gene/2585118:FMF02_RS11255 ^@ http://purl.uniprot.org/uniprot/A0A3D3YP18 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MscL family.|||Cell membrane|||Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.|||Homopentamer.|||Membrane http://togogenome.org/gene/2585118:FMF02_RS08240 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WTT6 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/2585118:FMF02_RS10890 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WV86 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/2585118:FMF02_RS01430 ^@ http://purl.uniprot.org/uniprot/A0A3D3YKY7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of glycine to tRNA(Gly).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2585118:FMF02_RS06425 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WUL8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/2585118:FMF02_RS01320 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XQF7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/2585118:FMF02_RS04875 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WU11 ^@ Similarity ^@ Belongs to the type IA topoisomerase family. http://togogenome.org/gene/2585118:FMF02_RS07145 ^@ http://purl.uniprot.org/uniprot/A0A3D2BBI1 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/2585118:FMF02_RS03860 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WQV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.|||Cell inner membrane|||Cell membrane|||Membrane|||Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. http://togogenome.org/gene/2585118:FMF02_RS00790 ^@ http://purl.uniprot.org/uniprot/A0A3D3YJ09 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).|||Cell membrane|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. http://togogenome.org/gene/2585118:FMF02_RS08305 ^@ http://purl.uniprot.org/uniprot/A0A3D3YIU9 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/2585118:FMF02_RS01405 ^@ http://purl.uniprot.org/uniprot/A0A3D3YKI1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/2585118:FMF02_RS07305 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WUJ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2585118:FMF02_RS06605 ^@ http://purl.uniprot.org/uniprot/A0A3D3YNA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/2585118:FMF02_RS04375 ^@ http://purl.uniprot.org/uniprot/A0A3D2BCW1 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/2585118:FMF02_RS06860 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WSG7 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/2585118:FMF02_RS11905 ^@ http://purl.uniprot.org/uniprot/A0A3D3YHH6 ^@ Function ^@ Might have a role analogous to that of eukaryotic histone proteins. http://togogenome.org/gene/2585118:FMF02_RS07725 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XJW7 ^@ Cofactor ^@ Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/2585118:FMF02_RS03855 ^@ http://purl.uniprot.org/uniprot/A0A3D3YMC0 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/2585118:FMF02_RS06090 ^@ http://purl.uniprot.org/uniprot/A0A3D3YP79 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspH family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. http://togogenome.org/gene/2585118:FMF02_RS01135 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WRN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetokinase family.|||Cytoplasm http://togogenome.org/gene/2585118:FMF02_RS02975 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WR41 ^@ Similarity ^@ Belongs to the transglycosylase Slt family. http://togogenome.org/gene/2585118:FMF02_RS06520 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XU11 ^@ Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase I family.|||Homopolymer. http://togogenome.org/gene/2585118:FMF02_RS10485 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WWZ1 ^@ Subcellular Location Annotation ^@ Cell outer membrane|||Membrane http://togogenome.org/gene/2585118:FMF02_RS00115 ^@ http://purl.uniprot.org/uniprot/A0A3D2BAT5 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/2585118:FMF02_RS11405 ^@ http://purl.uniprot.org/uniprot/A0A4Y1WVB1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/2585118:FMF02_RS01165 ^@ http://purl.uniprot.org/uniprot/A0A3D3YM62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/2585118:FMF02_RS08705 ^@ http://purl.uniprot.org/uniprot/A0A3D3YPT4 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. http://togogenome.org/gene/2585118:FMF02_RS02405 ^@ http://purl.uniprot.org/uniprot/A0A3D3YNM7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/2585118:FMF02_RS00015 ^@ http://purl.uniprot.org/uniprot/A0A3D2BEX2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2585118:FMF02_RS07935 ^@ http://purl.uniprot.org/uniprot/A0A3D2BBL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/2585118:FMF02_RS05100 ^@ http://purl.uniprot.org/uniprot/A0A3D3YPG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/2585118:FMF02_RS07405 ^@ http://purl.uniprot.org/uniprot/A0A3D3YN95 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/2585118:FMF02_RS09230 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XPK9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/2585118:FMF02_RS10075 ^@ http://purl.uniprot.org/uniprot/A0A3D3YKS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/2585118:FMF02_RS05160 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XRC4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/2585118:FMF02_RS05115 ^@ http://purl.uniprot.org/uniprot/A0A4Y1XRA4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit.