http://togogenome.org/gene/264636:EXC59_RS04840 ^@ http://purl.uniprot.org/uniprot/A0A449BKP0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/264636:EXC59_RS05870 ^@ http://purl.uniprot.org/uniprot/A0A449BLA0 ^@ Similarity ^@ Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. http://togogenome.org/gene/264636:EXC59_RS02905 ^@ http://purl.uniprot.org/uniprot/A0A449BJF1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type-II 3-dehydroquinase family.|||Catalyzes a trans-dehydration via an enolate intermediate.|||Homododecamer. http://togogenome.org/gene/264636:EXC59_RS00900 ^@ http://purl.uniprot.org/uniprot/A0A449BIB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS03300 ^@ http://purl.uniprot.org/uniprot/A0A449BJK2 ^@ Function|||Similarity ^@ Belongs to the UPF0122 family.|||Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein. http://togogenome.org/gene/264636:EXC59_RS05330 ^@ http://purl.uniprot.org/uniprot/A0A449BKN3 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/264636:EXC59_RS00990 ^@ http://purl.uniprot.org/uniprot/A0A449BIA4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 20 family. http://togogenome.org/gene/264636:EXC59_RS01475 ^@ http://purl.uniprot.org/uniprot/A0A449BIK3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/264636:EXC59_RS04620 ^@ http://purl.uniprot.org/uniprot/A0A449BKB3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/264636:EXC59_RS03415 ^@ http://purl.uniprot.org/uniprot/A0A449BJP2 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/264636:EXC59_RS01670 ^@ http://purl.uniprot.org/uniprot/A0A449BIN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/264636:EXC59_RS01085 ^@ http://purl.uniprot.org/uniprot/A0A449BIE5 ^@ Function|||Similarity ^@ Belongs to the NanE family.|||Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). http://togogenome.org/gene/264636:EXC59_RS04575 ^@ http://purl.uniprot.org/uniprot/A0A449BKD9 ^@ Caution|||Function|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. http://togogenome.org/gene/264636:EXC59_RS00795 ^@ http://purl.uniprot.org/uniprot/A0A449BI64 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/264636:EXC59_RS06155 ^@ http://purl.uniprot.org/uniprot/A0A449BL42 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/264636:EXC59_RS04470 ^@ http://purl.uniprot.org/uniprot/A0A449BKC3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase RlmH family.|||Cytoplasm|||Homodimer.|||Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. http://togogenome.org/gene/264636:EXC59_RS01210 ^@ http://purl.uniprot.org/uniprot/A0A449BIE7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/264636:EXC59_RS03710 ^@ http://purl.uniprot.org/uniprot/A0A449BJV5 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/264636:EXC59_RS01555 ^@ http://purl.uniprot.org/uniprot/A0A449BIK8 ^@ Function|||Similarity ^@ Belongs to the RecD family. RecD-like subfamily.|||DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity. http://togogenome.org/gene/264636:EXC59_RS00570 ^@ http://purl.uniprot.org/uniprot/A0A449BI31 ^@ Similarity ^@ Belongs to the DNA polymerase type-Y family. http://togogenome.org/gene/264636:EXC59_RS04645 ^@ http://purl.uniprot.org/uniprot/A0A449BKC5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/264636:EXC59_RS05345 ^@ http://purl.uniprot.org/uniprot/A0A449BKS8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA which binds and tethers DNA polymerases and other proteins to the DNA. The DNA replisome complex has a single clamp-loading complex (3 tau and 1 each of delta, delta', psi and chi subunits) which binds 3 Pol III cores (1 core on the leading strand and 2 on the lagging strand) each with a beta sliding clamp dimer. Additional proteins in the replisome are other copies of gamma, psi and chi, Ssb, DNA helicase and RNA primase. http://togogenome.org/gene/264636:EXC59_RS01860 ^@ http://purl.uniprot.org/uniprot/A0A449BIU8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphopentomutase family.|||Binds 1 or 2 manganese ions.|||Cytoplasm|||Phosphotransfer between the C1 and C5 carbon atoms of pentose. http://togogenome.org/gene/264636:EXC59_RS00885 ^@ http://purl.uniprot.org/uniprot/A0A449BI87 ^@ Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. http://togogenome.org/gene/264636:EXC59_RS06185 ^@ http://purl.uniprot.org/uniprot/A0A449BLA8 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/264636:EXC59_RS02575 ^@ http://purl.uniprot.org/uniprot/A0A449BJ84 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/264636:EXC59_RS04015 ^@ http://purl.uniprot.org/uniprot/A0A449BJZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS03565 ^@ http://purl.uniprot.org/uniprot/A0A449BJS3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS02475 ^@ http://purl.uniprot.org/uniprot/A0A449BJ47 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/264636:EXC59_RS04730 ^@ http://purl.uniprot.org/uniprot/A0A449BKM1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/264636:EXC59_RS00820 ^@ http://purl.uniprot.org/uniprot/A0A449BI77 ^@ Function ^@ This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/264636:EXC59_RS01795 ^@ http://purl.uniprot.org/uniprot/A0A449BIR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS03105 ^@ http://purl.uniprot.org/uniprot/A0A449BJJ7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvT family.|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/264636:EXC59_RS05460 ^@ http://purl.uniprot.org/uniprot/A0A449BL46 ^@ Similarity ^@ Belongs to the RpoE family. http://togogenome.org/gene/264636:EXC59_RS01760 ^@ http://purl.uniprot.org/uniprot/A0A449BIS8 ^@ Caution|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/264636:EXC59_RS03375 ^@ http://purl.uniprot.org/uniprot/A0A449BJL7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF2.|||Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. http://togogenome.org/gene/264636:EXC59_RS04940 ^@ http://purl.uniprot.org/uniprot/A0A449BKR0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/264636:EXC59_RS01820 ^@ http://purl.uniprot.org/uniprot/A0A449BIR5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS04685 ^@ http://purl.uniprot.org/uniprot/A0A449BKF4 ^@ Function|||Similarity ^@ Belongs to the sigma-70 factor family.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-S contributes to the protection against external stress, thus playing a role in cellular fitness and survival. http://togogenome.org/gene/264636:EXC59_RS02900 ^@ http://purl.uniprot.org/uniprot/A0A449BJR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/264636:EXC59_RS01220 ^@ http://purl.uniprot.org/uniprot/A0A449BIF0 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/264636:EXC59_RS06165 ^@ http://purl.uniprot.org/uniprot/A0A449BL99 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/264636:EXC59_RS02870 ^@ http://purl.uniprot.org/uniprot/A0A449BJC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Cytoplasm http://togogenome.org/gene/264636:EXC59_RS01745 ^@ http://purl.uniprot.org/uniprot/A0A449BIS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS02680 ^@ http://purl.uniprot.org/uniprot/A0A449BJ88 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS02590 ^@ http://purl.uniprot.org/uniprot/A0A449BJ64 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/264636:EXC59_RS06530 ^@ http://purl.uniprot.org/uniprot/A0A449BLD5 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/264636:EXC59_RS01205 ^@ http://purl.uniprot.org/uniprot/A0A449BIK4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS00245 ^@ http://purl.uniprot.org/uniprot/A0A449BHW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Membrane http://togogenome.org/gene/264636:EXC59_RS04945 ^@ http://purl.uniprot.org/uniprot/A0A449BKL6 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/264636:EXC59_RS03305 ^@ http://purl.uniprot.org/uniprot/A0A449BJZ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Membrane|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/264636:EXC59_RS06585 ^@ http://purl.uniprot.org/uniprot/A0A449BLG0 ^@ Similarity ^@ Belongs to the AlaDH/PNT family. http://togogenome.org/gene/264636:EXC59_RS00815 ^@ http://purl.uniprot.org/uniprot/A0A449BI81 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/264636:EXC59_RS04335 ^@ http://purl.uniprot.org/uniprot/A0A449BKC7 ^@ Similarity ^@ Belongs to the peptidase M29 family. http://togogenome.org/gene/264636:EXC59_RS03765 ^@ http://purl.uniprot.org/uniprot/A0A449BJZ7 ^@ Similarity ^@ Belongs to the CvfB family. http://togogenome.org/gene/264636:EXC59_RS00510 ^@ http://purl.uniprot.org/uniprot/A0A449BI19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS05105 ^@ http://purl.uniprot.org/uniprot/A0A449BKL0 ^@ Similarity ^@ Belongs to the transketolase family. http://togogenome.org/gene/264636:EXC59_RS04905 ^@ http://purl.uniprot.org/uniprot/A0A449BKH5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/264636:EXC59_RS04745 ^@ http://purl.uniprot.org/uniprot/A0A449BKE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS00875 ^@ http://purl.uniprot.org/uniprot/A0A449BIK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BioY family.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS04640 ^@ http://purl.uniprot.org/uniprot/A0A449BKB5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/264636:EXC59_RS06275 ^@ http://purl.uniprot.org/uniprot/A0A449BL91 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/264636:EXC59_RS04560 ^@ http://purl.uniprot.org/uniprot/A0A449BKC1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS04615 ^@ http://purl.uniprot.org/uniprot/A0A449BKF8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/264636:EXC59_RS00935 ^@ http://purl.uniprot.org/uniprot/A0A449BI97 ^@ Function|||Similarity ^@ Belongs to the RecN family.|||May be involved in recombinational repair of damaged DNA. http://togogenome.org/gene/264636:EXC59_RS00095 ^@ http://purl.uniprot.org/uniprot/A0A449BHT1 ^@ Similarity ^@ Belongs to the V-ATPase F subunit family. http://togogenome.org/gene/264636:EXC59_RS04360 ^@ http://purl.uniprot.org/uniprot/A0A449BK82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/264636:EXC59_RS02170 ^@ http://purl.uniprot.org/uniprot/A0A449BIY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS00750 ^@ http://purl.uniprot.org/uniprot/A0A449BI79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/264636:EXC59_RS02580 ^@ http://purl.uniprot.org/uniprot/A0A449BJD5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.|||Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.|||Homodimer. http://togogenome.org/gene/264636:EXC59_RS06855 ^@ http://purl.uniprot.org/uniprot/A0A449BLK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS02940 ^@ http://purl.uniprot.org/uniprot/A0A449BJD3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase Y family.|||Cell membrane|||Endoribonuclease that initiates mRNA decay. http://togogenome.org/gene/264636:EXC59_RS05400 ^@ http://purl.uniprot.org/uniprot/A0A449BKP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS05360 ^@ http://purl.uniprot.org/uniprot/A0A449BL26 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RnpA family.|||Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.|||RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. http://togogenome.org/gene/264636:EXC59_RS04835 ^@ http://purl.uniprot.org/uniprot/A0A449BKJ1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/264636:EXC59_RS00760 ^@ http://purl.uniprot.org/uniprot/A0A449BI61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS02685 ^@ http://purl.uniprot.org/uniprot/A0A449BJ85 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/264636:EXC59_RS03995 ^@ http://purl.uniprot.org/uniprot/A0A449BKC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/264636:EXC59_RS01320 ^@ http://purl.uniprot.org/uniprot/A0A449BIH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/264636:EXC59_RS04935 ^@ http://purl.uniprot.org/uniprot/A0A449BKL7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/264636:EXC59_RS03190 ^@ http://purl.uniprot.org/uniprot/A0A449BJI3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell membrane|||Membrane http://togogenome.org/gene/264636:EXC59_RS01225 ^@ http://purl.uniprot.org/uniprot/A0A449BIU2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS01490 ^@ http://purl.uniprot.org/uniprot/A0A449BIM4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsY family.|||Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.|||Cell membrane|||Probably interacts with PlsX. http://togogenome.org/gene/264636:EXC59_RS01965 ^@ http://purl.uniprot.org/uniprot/A0A449BJ02 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/264636:EXC59_RS05470 ^@ http://purl.uniprot.org/uniprot/A0A449BKT2 ^@ Cofactor ^@ Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/264636:EXC59_RS01715 ^@ http://purl.uniprot.org/uniprot/A0A449BIU9 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/264636:EXC59_RS05380 ^@ http://purl.uniprot.org/uniprot/A0A449BKP6 ^@ Function|||Similarity ^@ Belongs to the RmuC family.|||Involved in DNA recombination. http://togogenome.org/gene/264636:EXC59_RS03700 ^@ http://purl.uniprot.org/uniprot/A0A449BK70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/264636:EXC59_RS04790 ^@ http://purl.uniprot.org/uniprot/A0A449BKH2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS06195 ^@ http://purl.uniprot.org/uniprot/A0A449BL53 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/264636:EXC59_RS01410 ^@ http://purl.uniprot.org/uniprot/A0A449BIP2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. http://togogenome.org/gene/264636:EXC59_RS04880 ^@ http://purl.uniprot.org/uniprot/A0A449BKG7 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/264636:EXC59_RS01800 ^@ http://purl.uniprot.org/uniprot/A0A449BIT5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/264636:EXC59_RS02700 ^@ http://purl.uniprot.org/uniprot/A0A449BJA9 ^@ Similarity ^@ Belongs to the UDPGP type 2 family. http://togogenome.org/gene/264636:EXC59_RS05550 ^@ http://purl.uniprot.org/uniprot/A0A449BKW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/264636:EXC59_RS04865 ^@ http://purl.uniprot.org/uniprot/A0A449BKI7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/264636:EXC59_RS02255 ^@ http://purl.uniprot.org/uniprot/A0A449BIZ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS05635 ^@ http://purl.uniprot.org/uniprot/A0A449BKY8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. http://togogenome.org/gene/264636:EXC59_RS04580 ^@ http://purl.uniprot.org/uniprot/A0A449BKH9 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with bS18 to 16S ribosomal RNA. http://togogenome.org/gene/264636:EXC59_RS05265 ^@ http://purl.uniprot.org/uniprot/A0A449BKM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/264636:EXC59_RS02865 ^@ http://purl.uniprot.org/uniprot/A0A449BJF5 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/264636:EXC59_RS04625 ^@ http://purl.uniprot.org/uniprot/A0A449BKF0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/264636:EXC59_RS04875 ^@ http://purl.uniprot.org/uniprot/A0A449BKL3 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/264636:EXC59_RS05260 ^@ http://purl.uniprot.org/uniprot/A0A449BL08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.|||Cytoplasm|||In the C-terminal section; belongs to the helicase family. RecG subfamily.|||In the N-terminal section; belongs to the UvrB family. http://togogenome.org/gene/264636:EXC59_RS05630 ^@ http://purl.uniprot.org/uniprot/A0A449BKU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acetylates the N-terminal alanine of ribosomal protein bS18.|||Belongs to the acetyltransferase family. RimI subfamily.|||Cytoplasm http://togogenome.org/gene/264636:EXC59_RS01165 ^@ http://purl.uniprot.org/uniprot/A0A449BIE8 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/264636:EXC59_RS04825 ^@ http://purl.uniprot.org/uniprot/A0A449BKJ5 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/264636:EXC59_RS00270 ^@ http://purl.uniprot.org/uniprot/A0A449BHW8 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/264636:EXC59_RS02745 ^@ http://purl.uniprot.org/uniprot/A0A449BJN3 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/264636:EXC59_RS00505 ^@ http://purl.uniprot.org/uniprot/A0A449BI29 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS04315 ^@ http://purl.uniprot.org/uniprot/A0A449BK76 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/264636:EXC59_RS04610 ^@ http://purl.uniprot.org/uniprot/A0A449BKD1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/264636:EXC59_RS05670 ^@ http://purl.uniprot.org/uniprot/A0A449BKX2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/264636:EXC59_RS01450 ^@ http://purl.uniprot.org/uniprot/A0A449BII8 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/264636:EXC59_RS01505 ^@ http://purl.uniprot.org/uniprot/A0A449BIJ8 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/264636:EXC59_RS02955 ^@ http://purl.uniprot.org/uniprot/A0A449BJG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/264636:EXC59_RS04505 ^@ http://purl.uniprot.org/uniprot/A0A449BKB8 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/264636:EXC59_RS05130 ^@ http://purl.uniprot.org/uniprot/A0A449BKP1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL31 family. http://togogenome.org/gene/264636:EXC59_RS06960 ^@ http://purl.uniprot.org/uniprot/A0A449BLM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/264636:EXC59_RS03680 ^@ http://purl.uniprot.org/uniprot/A0A449BJU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS05175 ^@ http://purl.uniprot.org/uniprot/A0A449BKK6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.|||Binds 2 [4Fe-4S] clusters per subunit.|||Cell membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/264636:EXC59_RS03080 ^@ http://purl.uniprot.org/uniprot/A0A449BJN6 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/264636:EXC59_RS03325 ^@ http://purl.uniprot.org/uniprot/A0A449BJK7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/264636:EXC59_RS01915 ^@ http://purl.uniprot.org/uniprot/A0A449BIZ1 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/264636:EXC59_RS04460 ^@ http://purl.uniprot.org/uniprot/A0A449BKA9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MscL family.|||Cell membrane|||Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.|||Homopentamer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/264636:EXC59_RS03640 ^@ http://purl.uniprot.org/uniprot/A0A449BJS2 ^@ Similarity ^@ Belongs to the acetyl-CoA hydrolase/transferase family. http://togogenome.org/gene/264636:EXC59_RS04245 ^@ http://purl.uniprot.org/uniprot/A0A449BK34 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/264636:EXC59_RS00695 ^@ http://purl.uniprot.org/uniprot/A0A449BI43 ^@ Similarity ^@ Belongs to the desulfoferrodoxin family. http://togogenome.org/gene/264636:EXC59_RS00880 ^@ http://purl.uniprot.org/uniprot/A0A449BI98 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the ferredoxin--NADP reductase type 2 family.|||Binds 1 FAD per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/264636:EXC59_RS05540 ^@ http://purl.uniprot.org/uniprot/A0A449BKW4 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/264636:EXC59_RS04670 ^@ http://purl.uniprot.org/uniprot/A0A449BKC4 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/264636:EXC59_RS04855 ^@ http://purl.uniprot.org/uniprot/A0A449BKG5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/264636:EXC59_RS03230 ^@ http://purl.uniprot.org/uniprot/A0A449BJK1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/264636:EXC59_RS00495 ^@ http://purl.uniprot.org/uniprot/A0A449BI51 ^@ Similarity ^@ Belongs to the BMP lipoprotein family. http://togogenome.org/gene/264636:EXC59_RS00675 ^@ http://purl.uniprot.org/uniprot/A0A449BI58 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HsdR family.|||Subunit R is required for both nuclease and ATPase activities, but not for modification.|||The type I restriction/modification system is composed of three polypeptides R, M and S. http://togogenome.org/gene/264636:EXC59_RS04950 ^@ http://purl.uniprot.org/uniprot/A0A449BKH4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/264636:EXC59_RS03365 ^@ http://purl.uniprot.org/uniprot/A0A449BJN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RecX family.|||Cytoplasm http://togogenome.org/gene/264636:EXC59_RS03165 ^@ http://purl.uniprot.org/uniprot/A0A449BJL9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/264636:EXC59_RS04850 ^@ http://purl.uniprot.org/uniprot/A0A449BKF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/264636:EXC59_RS04925 ^@ http://purl.uniprot.org/uniprot/A0A449BKM0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/264636:EXC59_RS04380 ^@ http://purl.uniprot.org/uniprot/A0A449BK95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribonuclease III family.|||Cytoplasm|||Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.|||Homodimer. http://togogenome.org/gene/264636:EXC59_RS04725 ^@ http://purl.uniprot.org/uniprot/A0A449BKH0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/264636:EXC59_RS06030 ^@ http://purl.uniprot.org/uniprot/A0A449BLA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS06415 ^@ http://purl.uniprot.org/uniprot/A0A449BLB5 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/264636:EXC59_RS06600 ^@ http://purl.uniprot.org/uniprot/A0A449BLF3 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/264636:EXC59_RS01610 ^@ http://purl.uniprot.org/uniprot/A0A449BIQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS02015 ^@ http://purl.uniprot.org/uniprot/A0A449BIX7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS03625 ^@ http://purl.uniprot.org/uniprot/A0A449BJR8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/264636:EXC59_RS06630 ^@ http://purl.uniprot.org/uniprot/A0A449BLF1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.|||Cytoplasm|||Homotrimer.|||In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/264636:EXC59_RS02570 ^@ http://purl.uniprot.org/uniprot/A0A449BJ55 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/264636:EXC59_RS05225 ^@ http://purl.uniprot.org/uniprot/A0A449BKQ7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.|||Belongs to the organic radical-activating enzymes family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm http://togogenome.org/gene/264636:EXC59_RS04920 ^@ http://purl.uniprot.org/uniprot/A0A449BKJ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/264636:EXC59_RS00040 ^@ http://purl.uniprot.org/uniprot/A0A449BHS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/264636:EXC59_RS01640 ^@ http://purl.uniprot.org/uniprot/A0A449BIQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/264636:EXC59_RS05250 ^@ http://purl.uniprot.org/uniprot/A0A449BKK8 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/264636:EXC59_RS03490 ^@ http://purl.uniprot.org/uniprot/A0A449BJP4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the GTP cyclohydrolase II family.|||Binds 1 zinc ion per subunit.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.|||In the N-terminal section; belongs to the DHBP synthase family. http://togogenome.org/gene/264636:EXC59_RS02505 ^@ http://purl.uniprot.org/uniprot/A0A449BJ83 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/264636:EXC59_RS03955 ^@ http://purl.uniprot.org/uniprot/A0A449BK03 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS04045 ^@ http://purl.uniprot.org/uniprot/A0A449BKD5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.|||Belongs to the azoreductase type 1 family.|||Binds 1 FMN per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones. http://togogenome.org/gene/264636:EXC59_RS02290 ^@ http://purl.uniprot.org/uniprot/A0A449BJ34 ^@ Cofactor ^@ Binds 2 magnesium ions per subunit. http://togogenome.org/gene/264636:EXC59_RS01790 ^@ http://purl.uniprot.org/uniprot/A0A449BIT7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.|||Cell membrane|||Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/264636:EXC59_RS00905 ^@ http://purl.uniprot.org/uniprot/A0A449BID2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS03655 ^@ http://purl.uniprot.org/uniprot/A0A449BK63 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/264636:EXC59_RS02910 ^@ http://purl.uniprot.org/uniprot/A0A449BJD0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/264636:EXC59_RS04530 ^@ http://purl.uniprot.org/uniprot/A0A449BKG6 ^@ Function ^@ Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. http://togogenome.org/gene/264636:EXC59_RS04495 ^@ http://purl.uniprot.org/uniprot/A0A449BK94 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/264636:EXC59_RS05385 ^@ http://purl.uniprot.org/uniprot/A0A449BKT5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/264636:EXC59_RS02395 ^@ http://purl.uniprot.org/uniprot/A0A449BJ32 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/264636:EXC59_RS06150 ^@ http://purl.uniprot.org/uniprot/A0A449BL79 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/264636:EXC59_RS03205 ^@ http://purl.uniprot.org/uniprot/A0A449BJX8 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvA family.|||Cytoplasm|||Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.|||Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/264636:EXC59_RS06725 ^@ http://purl.uniprot.org/uniprot/A0A449BLH6 ^@ Function|||Similarity ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family.|||Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. http://togogenome.org/gene/264636:EXC59_RS05280 ^@ http://purl.uniprot.org/uniprot/A0A449BKM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/264636:EXC59_RS01825 ^@ http://purl.uniprot.org/uniprot/A0A449BIS1 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.|||Synthesizes alpha-1,4-glucan chains using ADP-glucose. http://togogenome.org/gene/264636:EXC59_RS03170 ^@ http://purl.uniprot.org/uniprot/A0A449BJI0 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/264636:EXC59_RS06215 ^@ http://purl.uniprot.org/uniprot/A0A449BL88 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/264636:EXC59_RS06640 ^@ http://purl.uniprot.org/uniprot/A0A449BLG4 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/264636:EXC59_RS05315 ^@ http://purl.uniprot.org/uniprot/A0A449BKN2 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/264636:EXC59_RS03330 ^@ http://purl.uniprot.org/uniprot/A0A449BJM3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/264636:EXC59_RS01740 ^@ http://purl.uniprot.org/uniprot/A0A449BIQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/264636:EXC59_RS05810 ^@ http://purl.uniprot.org/uniprot/A0A449BKX7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/264636:EXC59_RS06790 ^@ http://purl.uniprot.org/uniprot/A0A449BLK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS00615 ^@ http://purl.uniprot.org/uniprot/A0A449BIF2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS05295 ^@ http://purl.uniprot.org/uniprot/A0A449BKR8 ^@ Function|||Similarity ^@ Belongs to the PduL family.|||Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. http://togogenome.org/gene/264636:EXC59_RS01150 ^@ http://purl.uniprot.org/uniprot/A0A449BIG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/264636:EXC59_RS03215 ^@ http://purl.uniprot.org/uniprot/A0A449BJK0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/264636:EXC59_RS06620 ^@ http://purl.uniprot.org/uniprot/A0A449BLF9 ^@ Similarity ^@ Belongs to the polysaccharide synthase family. http://togogenome.org/gene/264636:EXC59_RS05650 ^@ http://purl.uniprot.org/uniprot/A0A449BKU4 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/264636:EXC59_RS00225 ^@ http://purl.uniprot.org/uniprot/A0A449BHX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/264636:EXC59_RS00110 ^@ http://purl.uniprot.org/uniprot/A0A449BI56 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/264636:EXC59_RS00125 ^@ http://purl.uniprot.org/uniprot/A0A449BHV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS01525 ^@ http://purl.uniprot.org/uniprot/A0A449BIL4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/264636:EXC59_RS02885 ^@ http://purl.uniprot.org/uniprot/A0A449BJC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/264636:EXC59_RS05570 ^@ http://purl.uniprot.org/uniprot/A0A449BKV2 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/264636:EXC59_RS06550 ^@ http://purl.uniprot.org/uniprot/A0A449BLE3 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily. http://togogenome.org/gene/264636:EXC59_RS01550 ^@ http://purl.uniprot.org/uniprot/A0A449BIN8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/264636:EXC59_RS05155 ^@ http://purl.uniprot.org/uniprot/A0A449BKZ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS01865 ^@ http://purl.uniprot.org/uniprot/A0A449BIY2 ^@ Similarity ^@ Belongs to the asparaginase 1 family. http://togogenome.org/gene/264636:EXC59_RS04870 ^@ http://purl.uniprot.org/uniprot/A0A449BKI1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/264636:EXC59_RS04555 ^@ http://purl.uniprot.org/uniprot/A0A449BKC9 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. http://togogenome.org/gene/264636:EXC59_RS06805 ^@ http://purl.uniprot.org/uniprot/A0A449BLJ2 ^@ Similarity ^@ Belongs to the N-acylglucosamine 2-epimerase family. http://togogenome.org/gene/264636:EXC59_RS06070 ^@ http://purl.uniprot.org/uniprot/A0A449BL65 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/264636:EXC59_RS01140 ^@ http://purl.uniprot.org/uniprot/A0A449BIF7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS04090 ^@ http://purl.uniprot.org/uniprot/A0A449BK10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS03575 ^@ http://purl.uniprot.org/uniprot/A0A449BJQ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS04655 ^@ http://purl.uniprot.org/uniprot/A0A449BKE9 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/264636:EXC59_RS03545 ^@ http://purl.uniprot.org/uniprot/A0A449BJP9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/264636:EXC59_RS02915 ^@ http://purl.uniprot.org/uniprot/A0A449BJG9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/264636:EXC59_RS00190 ^@ http://purl.uniprot.org/uniprot/A0A449BHZ4 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/264636:EXC59_RS02925 ^@ http://purl.uniprot.org/uniprot/A0A449BJE9 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. http://togogenome.org/gene/264636:EXC59_RS00185 ^@ http://purl.uniprot.org/uniprot/A0A449BHX0 ^@ Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Homodimer. http://togogenome.org/gene/264636:EXC59_RS05180 ^@ http://purl.uniprot.org/uniprot/A0A449BKP8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/264636:EXC59_RS04830 ^@ http://purl.uniprot.org/uniprot/A0A449BKF6 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/264636:EXC59_RS05355 ^@ http://purl.uniprot.org/uniprot/A0A449BKN6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/264636:EXC59_RS04630 ^@ http://purl.uniprot.org/uniprot/A0A449BKI9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/264636:EXC59_RS06420 ^@ http://purl.uniprot.org/uniprot/A0A449BLB2 ^@ Function|||Similarity ^@ Belongs to the TrhO family.|||Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs. http://togogenome.org/gene/264636:EXC59_RS01190 ^@ http://purl.uniprot.org/uniprot/A0A449BIH2 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/264636:EXC59_RS03035 ^@ http://purl.uniprot.org/uniprot/A0A449BJF2 ^@ Similarity ^@ Belongs to the UPF0473 family. http://togogenome.org/gene/264636:EXC59_RS03735 ^@ http://purl.uniprot.org/uniprot/A0A449BJV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.|||Cytoplasm|||Interacts with 100S ribosomes.|||Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. http://togogenome.org/gene/264636:EXC59_RS04845 ^@ http://purl.uniprot.org/uniprot/A0A449BKI3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/264636:EXC59_RS01500 ^@ http://purl.uniprot.org/uniprot/A0A449BIM8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/264636:EXC59_RS06605 ^@ http://purl.uniprot.org/uniprot/A0A449BLF7 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-allosteric. http://togogenome.org/gene/264636:EXC59_RS03965 ^@ http://purl.uniprot.org/uniprot/A0A449BK33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0410 family.|||Membrane http://togogenome.org/gene/264636:EXC59_RS04250 ^@ http://purl.uniprot.org/uniprot/A0A449BK39 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/264636:EXC59_RS05545 ^@ http://purl.uniprot.org/uniprot/A0A449BL02 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS03290 ^@ http://purl.uniprot.org/uniprot/A0A449BJK4 ^@ Function|||Similarity ^@ Belongs to the DNA polymerase type-A family.|||In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. http://togogenome.org/gene/264636:EXC59_RS04700 ^@ http://purl.uniprot.org/uniprot/A0A449BKR6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MrnC RNase family.|||Cytoplasm|||Homodimer.|||Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors. http://togogenome.org/gene/264636:EXC59_RS06735 ^@ http://purl.uniprot.org/uniprot/A0A449BLI6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/264636:EXC59_RS01090 ^@ http://purl.uniprot.org/uniprot/A0A449BIC5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/264636:EXC59_RS01855 ^@ http://purl.uniprot.org/uniprot/A0A449BIR4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerC subfamily.|||Belongs to the 'phage' integrase family. XerD subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/264636:EXC59_RS04515 ^@ http://purl.uniprot.org/uniprot/A0A449BKD6 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/264636:EXC59_RS04885 ^@ http://purl.uniprot.org/uniprot/A0A449BKK2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/264636:EXC59_RS04345 ^@ http://purl.uniprot.org/uniprot/A0A449BK55 ^@ Function|||Similarity ^@ Belongs to the flavodoxin family.|||Low-potential electron donor to a number of redox enzymes. http://togogenome.org/gene/264636:EXC59_RS02750 ^@ http://purl.uniprot.org/uniprot/A0A449BJC4 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/264636:EXC59_RS04755 ^@ http://purl.uniprot.org/uniprot/A0A449BKG9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/264636:EXC59_RS06235 ^@ http://purl.uniprot.org/uniprot/A0A449BL60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Cytoplasm|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. http://togogenome.org/gene/264636:EXC59_RS05270 ^@ http://purl.uniprot.org/uniprot/A0A449BKN4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/264636:EXC59_RS00180 ^@ http://purl.uniprot.org/uniprot/A0A449BHU3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M32 family.|||Binds 1 zinc ion per subunit.|||Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. http://togogenome.org/gene/264636:EXC59_RS04760 ^@ http://purl.uniprot.org/uniprot/A0A449BKG1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.|||Cytoplasm|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/264636:EXC59_RS01400 ^@ http://purl.uniprot.org/uniprot/A0A449BII0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS00670 ^@ http://purl.uniprot.org/uniprot/A0A449BIG0 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/264636:EXC59_RS04320 ^@ http://purl.uniprot.org/uniprot/A0A449BK97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69) family.|||Cell membrane|||Membrane http://togogenome.org/gene/264636:EXC59_RS02550 ^@ http://purl.uniprot.org/uniprot/A0A449BJ77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm|||Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. http://togogenome.org/gene/264636:EXC59_RS01780 ^@ http://purl.uniprot.org/uniprot/A0A449BIQ6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/264636:EXC59_RS00165 ^@ http://purl.uniprot.org/uniprot/A0A449BHV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/264636:EXC59_RS05395 ^@ http://purl.uniprot.org/uniprot/A0A449BKT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS03455 ^@ http://purl.uniprot.org/uniprot/A0A449BK27 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/264636:EXC59_RS06720 ^@ http://purl.uniprot.org/uniprot/A0A449BLH9 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. http://togogenome.org/gene/264636:EXC59_RS02960 ^@ http://purl.uniprot.org/uniprot/A0A449BJE1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/264636:EXC59_RS01240 ^@ http://purl.uniprot.org/uniprot/A0A449BII4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/264636:EXC59_RS01870 ^@ http://purl.uniprot.org/uniprot/A0A449BIS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0154 family.|||Membrane http://togogenome.org/gene/264636:EXC59_RS01815 ^@ http://purl.uniprot.org/uniprot/A0A449BIX2 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/264636:EXC59_RS04055 ^@ http://purl.uniprot.org/uniprot/A0A449BK23 ^@ Caution|||Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.|||Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/264636:EXC59_RS01330 ^@ http://purl.uniprot.org/uniprot/A0A449BIW2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS04260 ^@ http://purl.uniprot.org/uniprot/A0A449BK59 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/264636:EXC59_RS00275 ^@ http://purl.uniprot.org/uniprot/A0A449BHY0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/264636:EXC59_RS04160 ^@ http://purl.uniprot.org/uniprot/A0A449BK68 ^@ Function|||Similarity ^@ Belongs to the anhydro-N-acetylmuramic acid kinase family.|||Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. http://togogenome.org/gene/264636:EXC59_RS06565 ^@ http://purl.uniprot.org/uniprot/A0A449BLE9 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 9 family. http://togogenome.org/gene/264636:EXC59_RS03760 ^@ http://purl.uniprot.org/uniprot/A0A449BJW5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/264636:EXC59_RS02875 ^@ http://purl.uniprot.org/uniprot/A0A449BJD9 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/264636:EXC59_RS01830 ^@ http://purl.uniprot.org/uniprot/A0A449BIR9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.|||Homotetramer.|||Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. http://togogenome.org/gene/264636:EXC59_RS02950 ^@ http://purl.uniprot.org/uniprot/A0A449BJS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/264636:EXC59_RS01215 ^@ http://purl.uniprot.org/uniprot/A0A449BIF8 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/264636:EXC59_RS03000 ^@ http://purl.uniprot.org/uniprot/A0A449BJT7 ^@ Similarity ^@ Belongs to the Iojap/RsfS family. http://togogenome.org/gene/264636:EXC59_RS00915 ^@ http://purl.uniprot.org/uniprot/A0A449BIA1 ^@ Similarity ^@ Belongs to the NusB family. http://togogenome.org/gene/264636:EXC59_RS01665 ^@ http://purl.uniprot.org/uniprot/A0A449BIT9 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 3 family. http://togogenome.org/gene/264636:EXC59_RS04910 ^@ http://purl.uniprot.org/uniprot/A0A449BKV9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/264636:EXC59_RS01155 ^@ http://purl.uniprot.org/uniprot/A0A449BIJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/264636:EXC59_RS02645 ^@ http://purl.uniprot.org/uniprot/A0A449BJL4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/264636:EXC59_RS04000 ^@ http://purl.uniprot.org/uniprot/A0A449BK13 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 3 family. http://togogenome.org/gene/264636:EXC59_RS04425 ^@ http://purl.uniprot.org/uniprot/A0A449BK71 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/264636:EXC59_RS00045 ^@ http://purl.uniprot.org/uniprot/A0A449BHT0 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/264636:EXC59_RS03270 ^@ http://purl.uniprot.org/uniprot/A0A449BJN9 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/264636:EXC59_RS01405 ^@ http://purl.uniprot.org/uniprot/A0A449BIL1 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family.|||Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. http://togogenome.org/gene/264636:EXC59_RS04915 ^@ http://purl.uniprot.org/uniprot/A0A449BKJ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/264636:EXC59_RS01315 ^@ http://purl.uniprot.org/uniprot/A0A449BIG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/264636:EXC59_RS04860 ^@ http://purl.uniprot.org/uniprot/A0A449BKU7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.|||Cytoplasm|||Monomer. http://togogenome.org/gene/264636:EXC59_RS02420 ^@ http://purl.uniprot.org/uniprot/A0A449BJ38 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/264636:EXC59_RS04185 ^@ http://purl.uniprot.org/uniprot/A0A449BK24 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/264636:EXC59_RS04115 ^@ http://purl.uniprot.org/uniprot/A0A449BK11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS06615 ^@ http://purl.uniprot.org/uniprot/A0A449BLF8 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/264636:EXC59_RS05230 ^@ http://purl.uniprot.org/uniprot/A0A449BKL2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/264636:EXC59_RS06180 ^@ http://purl.uniprot.org/uniprot/A0A449BL50 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/264636:EXC59_RS00840 ^@ http://purl.uniprot.org/uniprot/A0A449BI91 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/264636:EXC59_RS04785 ^@ http://purl.uniprot.org/uniprot/A0A449BKN0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/264636:EXC59_RS05685 ^@ http://purl.uniprot.org/uniprot/A0A449BKZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS06090 ^@ http://purl.uniprot.org/uniprot/A0A449BL32 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/264636:EXC59_RS05805 ^@ http://purl.uniprot.org/uniprot/A0A449BL18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/264636:EXC59_RS00250 ^@ http://purl.uniprot.org/uniprot/A0A449BHX1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/264636:EXC59_RS01635 ^@ http://purl.uniprot.org/uniprot/A0A449BJ20 ^@ Similarity ^@ Belongs to the BMP lipoprotein family. http://togogenome.org/gene/264636:EXC59_RS03220 ^@ http://purl.uniprot.org/uniprot/A0A449BJM9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/264636:EXC59_RS03385 ^@ http://purl.uniprot.org/uniprot/A0A449BJU7 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/264636:EXC59_RS01440 ^@ http://purl.uniprot.org/uniprot/A0A449BIJ9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/264636:EXC59_RS02810 ^@ http://purl.uniprot.org/uniprot/A0A449BJB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/264636:EXC59_RS05365 ^@ http://purl.uniprot.org/uniprot/A0A449BKQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Cell membrane|||Membrane http://togogenome.org/gene/264636:EXC59_RS00285 ^@ http://purl.uniprot.org/uniprot/A0A449BHZ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of glycine to tRNA(Gly).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/264636:EXC59_RS05145 ^@ http://purl.uniprot.org/uniprot/A0A449BKJ4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ApbE family.|||Cell inner membrane|||Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.|||Magnesium. Can also use manganese. http://togogenome.org/gene/264636:EXC59_RS05665 ^@ http://purl.uniprot.org/uniprot/A0A449BKV7 ^@ Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. http://togogenome.org/gene/264636:EXC59_RS06225 ^@ http://purl.uniprot.org/uniprot/A0A449BL85 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/264636:EXC59_RS02070 ^@ http://purl.uniprot.org/uniprot/A0A449BIW5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS02595 ^@ http://purl.uniprot.org/uniprot/A0A449BJ66 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/264636:EXC59_RS00050 ^@ http://purl.uniprot.org/uniprot/A0A449BHS6 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/264636:EXC59_RS05680 ^@ http://purl.uniprot.org/uniprot/A0A449BKV1 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the HPrK/P family.|||Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.|||Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).|||Homohexamer.|||The Walker A ATP-binding motif also binds Pi and PPi. http://togogenome.org/gene/264636:EXC59_RS02280 ^@ http://purl.uniprot.org/uniprot/A0A449BJ09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS06210 ^@ http://purl.uniprot.org/uniprot/A0A449BL51 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M3B family.|||Binds 1 zinc ion.|||Has oligopeptidase activity and degrades a variety of small bioactive peptides. http://togogenome.org/gene/264636:EXC59_RS04545 ^@ http://purl.uniprot.org/uniprot/A0A449BKA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/264636:EXC59_RS05320 ^@ http://purl.uniprot.org/uniprot/A0A449BKP9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS05445 ^@ http://purl.uniprot.org/uniprot/A0A449BKU5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DnaX/STICHEL family.|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/264636:EXC59_RS03295 ^@ http://purl.uniprot.org/uniprot/A0A449BJK3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/264636:EXC59_RS03195 ^@ http://purl.uniprot.org/uniprot/A0A449BJI5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueA family.|||Cytoplasm|||Monomer.|||Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). http://togogenome.org/gene/264636:EXC59_RS03450 ^@ http://purl.uniprot.org/uniprot/A0A449BJN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RimP family.|||Cytoplasm|||Required for maturation of 30S ribosomal subunits. http://togogenome.org/gene/264636:EXC59_RS06105 ^@ http://purl.uniprot.org/uniprot/A0A449BL31 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/264636:EXC59_RS00650 ^@ http://purl.uniprot.org/uniprot/A0A449BI42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PEP-utilizing enzyme family.|||Cytoplasm|||General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). http://togogenome.org/gene/264636:EXC59_RS00140 ^@ http://purl.uniprot.org/uniprot/A0A449BHY4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS03425 ^@ http://purl.uniprot.org/uniprot/A0A449BJM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/264636:EXC59_RS04525 ^@ http://purl.uniprot.org/uniprot/A0A449BKD0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.|||Cytoplasm|||Monomer. http://togogenome.org/gene/264636:EXC59_RS05465 ^@ http://purl.uniprot.org/uniprot/A0A449BKR3 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/264636:EXC59_RS03020 ^@ http://purl.uniprot.org/uniprot/A0A449BJE7 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/264636:EXC59_RS00105 ^@ http://purl.uniprot.org/uniprot/A0A449BHT5 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. http://togogenome.org/gene/264636:EXC59_RS00455 ^@ http://purl.uniprot.org/uniprot/A0A449BI18 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/264636:EXC59_RS04265 ^@ http://purl.uniprot.org/uniprot/A0A449BK67 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/264636:EXC59_RS01025 ^@ http://purl.uniprot.org/uniprot/A0A449BID4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS03380 ^@ http://purl.uniprot.org/uniprot/A0A449BJN4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/264636:EXC59_RS05215 ^@ http://purl.uniprot.org/uniprot/A0A449BKL9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/264636:EXC59_RS01630 ^@ http://purl.uniprot.org/uniprot/A0A449BIM9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS05775 ^@ http://purl.uniprot.org/uniprot/A0A449BKX4 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/264636:EXC59_RS06265 ^@ http://purl.uniprot.org/uniprot/A0A449BL93 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/264636:EXC59_RS05440 ^@ http://purl.uniprot.org/uniprot/A0A449BKY5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/264636:EXC59_RS03445 ^@ http://purl.uniprot.org/uniprot/A0A449BJN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/264636:EXC59_RS05740 ^@ http://purl.uniprot.org/uniprot/A0A449BL09 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/264636:EXC59_RS01980 ^@ http://purl.uniprot.org/uniprot/A0A449BIV0 ^@ Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. http://togogenome.org/gene/264636:EXC59_RS02050 ^@ http://purl.uniprot.org/uniprot/A0A449BIZ2 ^@ Function|||Similarity ^@ Belongs to the methylglyoxal synthase family.|||Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. http://togogenome.org/gene/264636:EXC59_RS06010 ^@ http://purl.uniprot.org/uniprot/A0A449BL89 ^@ Similarity ^@ Belongs to the peptidase C56 family. http://togogenome.org/gene/264636:EXC59_RS00100 ^@ http://purl.uniprot.org/uniprot/A0A449BHU1 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. http://togogenome.org/gene/264636:EXC59_RS06940 ^@ http://purl.uniprot.org/uniprot/A0A449BLN3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/264636:EXC59_RS01485 ^@ http://purl.uniprot.org/uniprot/A0A449BIZ0 ^@ Similarity ^@ Belongs to the lipase/esterase LIP3/BchO family. http://togogenome.org/gene/264636:EXC59_RS06120 ^@ http://purl.uniprot.org/uniprot/A0A449BL72 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/264636:EXC59_RS01480 ^@ http://purl.uniprot.org/uniprot/A0A449BIJ6 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/264636:EXC59_RS01185 ^@ http://purl.uniprot.org/uniprot/A0A449BIF3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS05525 ^@ http://purl.uniprot.org/uniprot/A0A449BKU2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA(Ile)-lysidine synthase family.|||Cytoplasm|||Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.|||The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding. http://togogenome.org/gene/264636:EXC59_RS04570 ^@ http://purl.uniprot.org/uniprot/A0A449BKA2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6. http://togogenome.org/gene/264636:EXC59_RS03285 ^@ http://purl.uniprot.org/uniprot/A0A449BJS7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CoaE family.|||Belongs to the FPG family.|||Binds 1 zinc ion per subunit.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm|||Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.|||Monomer. http://togogenome.org/gene/264636:EXC59_RS03070 ^@ http://purl.uniprot.org/uniprot/A0A449BJF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.|||Belongs to the RNR ribonuclease family. RNase R subfamily.|||Cytoplasm http://togogenome.org/gene/264636:EXC59_RS01990 ^@ http://purl.uniprot.org/uniprot/A0A449BJ90 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/264636:EXC59_RS06850 ^@ http://purl.uniprot.org/uniprot/A0A449BLK2 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 1 family. http://togogenome.org/gene/264636:EXC59_RS04960 ^@ http://purl.uniprot.org/uniprot/A0A449BKX0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/264636:EXC59_RS05535 ^@ http://purl.uniprot.org/uniprot/A0A449BKS2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HSP33 family.|||Cytoplasm|||Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.|||Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive. http://togogenome.org/gene/264636:EXC59_RS00075 ^@ http://purl.uniprot.org/uniprot/A0A449BHU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/264636:EXC59_RS05275 ^@ http://purl.uniprot.org/uniprot/A0A449BKR7 ^@ Function|||Similarity ^@ Belongs to the SpoVG family.|||Could be involved in septation. http://togogenome.org/gene/264636:EXC59_RS01250 ^@ http://purl.uniprot.org/uniprot/A0A449BII3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/264636:EXC59_RS05325 ^@ http://purl.uniprot.org/uniprot/A0A449BKS7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/264636:EXC59_RS03150 ^@ http://purl.uniprot.org/uniprot/A0A449BJW6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.|||Cell membrane|||Heterotetramer composed of ParC and ParE.|||Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. http://togogenome.org/gene/264636:EXC59_RS05255 ^@ http://purl.uniprot.org/uniprot/A0A449BKL4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/264636:EXC59_RS06610 ^@ http://purl.uniprot.org/uniprot/A0A449BLF4 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/264636:EXC59_RS04890 ^@ http://purl.uniprot.org/uniprot/A0A449BKQ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/264636:EXC59_RS04895 ^@ http://purl.uniprot.org/uniprot/A0A449BKJ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/264636:EXC59_RS00950 ^@ http://purl.uniprot.org/uniprot/A0A449BIE1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AP endonuclease 2 family.|||Binds 3 Zn(2+) ions.|||Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. http://togogenome.org/gene/264636:EXC59_RS00255 ^@ http://purl.uniprot.org/uniprot/A0A449BHW7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/264636:EXC59_RS02965 ^@ http://purl.uniprot.org/uniprot/A0A449BJH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/264636:EXC59_RS04355 ^@ http://purl.uniprot.org/uniprot/A0A449BKJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/264636:EXC59_RS04120 ^@ http://purl.uniprot.org/uniprot/A0A449BK42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS01735 ^@ http://purl.uniprot.org/uniprot/A0A449BIS6 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/264636:EXC59_RS03090 ^@ http://purl.uniprot.org/uniprot/A0A449BJG7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the BPG-independent phosphoglycerate mutase family.|||Binds 2 manganese ions per subunit.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.|||Monomer. http://togogenome.org/gene/264636:EXC59_RS02605 ^@ http://purl.uniprot.org/uniprot/A0A449BJ71 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/264636:EXC59_RS05645 ^@ http://purl.uniprot.org/uniprot/A0A449BKY3 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/264636:EXC59_RS05350 ^@ http://purl.uniprot.org/uniprot/A0A449BKN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/264636:EXC59_RS04955 ^@ http://purl.uniprot.org/uniprot/A0A449BKI5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/264636:EXC59_RS04065 ^@ http://purl.uniprot.org/uniprot/A0A449BK00 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.|||Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.|||Homodimer.|||Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. http://togogenome.org/gene/264636:EXC59_RS02555 ^@ http://purl.uniprot.org/uniprot/A0A449BJ60 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/264636:EXC59_RS01510 ^@ http://purl.uniprot.org/uniprot/A0A449BIN0 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/264636:EXC59_RS03470 ^@ http://purl.uniprot.org/uniprot/A0A449BJT1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.|||Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.|||Cytoplasm|||Homodimer, may be a subunit of the RNA degradosome. http://togogenome.org/gene/264636:EXC59_RS02360 ^@ http://purl.uniprot.org/uniprot/A0A449BJ16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/264636:EXC59_RS02105 ^@ http://purl.uniprot.org/uniprot/A0A449BIW8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 20 family. http://togogenome.org/gene/264636:EXC59_RS06425 ^@ http://purl.uniprot.org/uniprot/A0A449BLB4 ^@ Similarity ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family. http://togogenome.org/gene/264636:EXC59_RS06035 ^@ http://purl.uniprot.org/uniprot/A0A449BL24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/264636:EXC59_RS04970 ^@ http://purl.uniprot.org/uniprot/A0A449BKJ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/264636:EXC59_RS04235 ^@ http://purl.uniprot.org/uniprot/A0A449BKB0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/264636:EXC59_RS03400 ^@ http://purl.uniprot.org/uniprot/A0A449BJM2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit.|||Binds 2 divalent ions per subunit.|||Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.|||Cytoplasm|||Homotetramer; dimer of dimers. http://togogenome.org/gene/264636:EXC59_RS02755 ^@ http://purl.uniprot.org/uniprot/A0A449BJ99 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A monovalent cation. Ammonium or potassium.|||Belongs to the type III pantothenate kinase family.|||Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/264636:EXC59_RS04965 ^@ http://purl.uniprot.org/uniprot/A0A449BKK5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/264636:EXC59_RS05095 ^@ http://purl.uniprot.org/uniprot/A0A449BKJ7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of a guanine in 16S rRNA. http://togogenome.org/gene/264636:EXC59_RS01645 ^@ http://purl.uniprot.org/uniprot/A0A449BIN6 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 3 family. http://togogenome.org/gene/264636:EXC59_RS06125 ^@ http://purl.uniprot.org/uniprot/A0A449BL33 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/264636:EXC59_RS05245 ^@ http://purl.uniprot.org/uniprot/A0A449BKQ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS06270 ^@ http://purl.uniprot.org/uniprot/A0A449BLA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/264636:EXC59_RS02415 ^@ http://purl.uniprot.org/uniprot/A0A449BJ96 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HsdR family.|||Subunit R is required for both nuclease and ATPase activities, but not for modification.|||The type I restriction/modification system is composed of three polypeptides R, M and S. http://togogenome.org/gene/264636:EXC59_RS00080 ^@ http://purl.uniprot.org/uniprot/A0A449BHS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane http://togogenome.org/gene/264636:EXC59_RS04275 ^@ http://purl.uniprot.org/uniprot/A0A449BK40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-C family. PolC subfamily.|||Cytoplasm|||Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/264636:EXC59_RS05455 ^@ http://purl.uniprot.org/uniprot/A0A449BKP5 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/264636:EXC59_RS02630 ^@ http://purl.uniprot.org/uniprot/A0A449BJ78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/264636:EXC59_RS02765 ^@ http://purl.uniprot.org/uniprot/A0A449BJA5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/264636:EXC59_RS00035 ^@ http://purl.uniprot.org/uniprot/A0A449BHW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane http://togogenome.org/gene/264636:EXC59_RS02665 ^@ http://purl.uniprot.org/uniprot/A0A449BJ79 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecU family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation. http://togogenome.org/gene/264636:EXC59_RS02165 ^@ http://purl.uniprot.org/uniprot/A0A449BJ48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS06740 ^@ http://purl.uniprot.org/uniprot/A0A449BLJ4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/264636:EXC59_RS01265 ^@ http://purl.uniprot.org/uniprot/A0A449BIF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/264636:EXC59_RS02110 ^@ http://purl.uniprot.org/uniprot/A0A449BIZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MgtC/SapB family.|||Membrane http://togogenome.org/gene/264636:EXC59_RS05555 ^@ http://purl.uniprot.org/uniprot/A0A449BKS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/264636:EXC59_RS02970 ^@ http://purl.uniprot.org/uniprot/A0A449BJE0 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/264636:EXC59_RS06795 ^@ http://purl.uniprot.org/uniprot/A0A449BLI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS00930 ^@ http://purl.uniprot.org/uniprot/A0A449BIB1 ^@ Similarity ^@ Belongs to the TlyA family. http://togogenome.org/gene/264636:EXC59_RS03590 ^@ http://purl.uniprot.org/uniprot/A0A449BJR3 ^@ Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/264636:EXC59_RS05760 ^@ http://purl.uniprot.org/uniprot/A0A449BKW7 ^@ Function|||Subunit ^@ Heterodimer of an alpha and a beta chain.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/264636:EXC59_RS04705 ^@ http://purl.uniprot.org/uniprot/A0A449BKF9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. http://togogenome.org/gene/264636:EXC59_RS04900 ^@ http://purl.uniprot.org/uniprot/A0A449BKG4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/264636:EXC59_RS01015 ^@ http://purl.uniprot.org/uniprot/A0A449BIB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/264636:EXC59_RS06170 ^@ http://purl.uniprot.org/uniprot/A0A449BL80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.|||Belongs to the KhpA RNA-binding protein family.|||Cytoplasm|||Forms a complex with KhpB. http://togogenome.org/gene/264636:EXC59_RS04735 ^@ http://purl.uniprot.org/uniprot/A0A449BKG3 ^@ Similarity ^@ Belongs to the SecB family. http://togogenome.org/gene/264636:EXC59_RS01600 ^@ http://purl.uniprot.org/uniprot/A0A449BIP7 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/264636:EXC59_RS00460 ^@ http://purl.uniprot.org/uniprot/A0A449BI10 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/264636:EXC59_RS06575 ^@ http://purl.uniprot.org/uniprot/A0A449BLE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/264636:EXC59_RS02715 ^@ http://purl.uniprot.org/uniprot/A0A449BJ92 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/264636:EXC59_RS04605 ^@ http://purl.uniprot.org/uniprot/A0A449BKE0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/264636:EXC59_RS00835 ^@ http://purl.uniprot.org/uniprot/A0A449BI76 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccA family.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/264636:EXC59_RS06305 ^@ http://purl.uniprot.org/uniprot/A0A449BL96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane