http://togogenome.org/gene/273063:STK_RS04685 ^@ http://purl.uniprot.org/uniprot/Q973Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/273063:STK_RS06880 ^@ http://purl.uniprot.org/uniprot/Q971Y3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm|||Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. http://togogenome.org/gene/273063:STK_RS02620 ^@ http://purl.uniprot.org/uniprot/F9VMZ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.|||Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure. http://togogenome.org/gene/273063:STK_RS02485 ^@ http://purl.uniprot.org/uniprot/P50455 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/273063:STK_RS06635 ^@ http://purl.uniprot.org/uniprot/Q972C8 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/273063:STK_RS08360 ^@ http://purl.uniprot.org/uniprot/F9VNF5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/273063:STK_RS07070 ^@ http://purl.uniprot.org/uniprot/Q971U4 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/273063:STK_RS01840 ^@ http://purl.uniprot.org/uniprot/Q975U7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo8 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/273063:STK_RS00380 ^@ http://purl.uniprot.org/uniprot/F9VMJ4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/273063:STK_RS00360 ^@ http://purl.uniprot.org/uniprot/Q976X3 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/273063:STK_RS02315 ^@ http://purl.uniprot.org/uniprot/F9VMX1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M54 family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.|||Monomer.|||Probable zinc metalloprotease whose natural substrate is unknown. http://togogenome.org/gene/273063:STK_RS01045 ^@ http://purl.uniprot.org/uniprot/Q976K2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.|||Homodimer. http://togogenome.org/gene/273063:STK_RS06620 ^@ http://purl.uniprot.org/uniprot/F9VNX0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NadC/ModD family.|||Hexamer formed by 3 homodimers.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/273063:STK_RS01865 ^@ http://purl.uniprot.org/uniprot/Q975U2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.|||Belongs to the AAA ATPase family.|||Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.|||Cytoplasm|||Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets. http://togogenome.org/gene/273063:STK_RS13080 ^@ http://purl.uniprot.org/uniprot/Q96XZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/273063:STK_RS06940 ^@ http://purl.uniprot.org/uniprot/Q971X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS12415 ^@ http://purl.uniprot.org/uniprot/Q96YC2 ^@ Function|||Similarity ^@ Belongs to the PGI/PMI family.|||Involved in the synthesis of UDP-N-acetylgalactosamine (UDP-GalNAc). Catalyzes the conversion of glucosamine-6-phosphate (GlcN-6-P) to galactosamine-6-phosphate (GalN-6-P). http://togogenome.org/gene/273063:STK_RS11950 ^@ http://purl.uniprot.org/uniprot/Q96YL0 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/273063:STK_RS05230 ^@ http://purl.uniprot.org/uniprot/Q973F1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/273063:STK_RS07665 ^@ http://purl.uniprot.org/uniprot/Q971J1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. Probably involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA. http://togogenome.org/gene/273063:STK_RS02230 ^@ http://purl.uniprot.org/uniprot/Q975M6 ^@ Similarity ^@ Belongs to the DMRL synthase family. http://togogenome.org/gene/273063:STK_RS00125 ^@ http://purl.uniprot.org/uniprot/Q977C2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/273063:STK_RS05695 ^@ http://purl.uniprot.org/uniprot/Q972W3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.|||Cytoplasm|||Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.|||Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. http://togogenome.org/gene/273063:STK_RS07720 ^@ http://purl.uniprot.org/uniprot/Q971H9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||May be involved in maturation of the 30S ribosomal subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/273063:STK_RS14470 ^@ http://purl.uniprot.org/uniprot/F9VPJ1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/273063:STK_RS00330 ^@ http://purl.uniprot.org/uniprot/Q976Y0 ^@ Similarity ^@ Belongs to the selenium-binding protein family. http://togogenome.org/gene/273063:STK_RS10450 ^@ http://purl.uniprot.org/uniprot/Q96ZF4 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/273063:STK_RS00455 ^@ http://purl.uniprot.org/uniprot/Q976V3 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/273063:STK_RS11685 ^@ http://purl.uniprot.org/uniprot/Q96YR4 ^@ Activity Regulation|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the NurA family.|||Homodimer (PubMed:21197557). Interacts with the single-stranded DNA-binding protein (SSB) (PubMed:18194801).|||Involved in DNA double-strand break (DSB) repair (By similarity). Acts probably with HerA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity). Exhibits both single-stranded endonuclease activity and 5'-3' exonuclease activity on single-stranded and double-stranded DNA (PubMed:18194801).|||The 5'-3' ssDNA and dsDNA exonuclease and ssDNA endonuclease activities are inhibited by SSB.|||The C-terminus is required for interaction with SSB. http://togogenome.org/gene/273063:STK_RS00155 ^@ http://purl.uniprot.org/uniprot/Q977B4 ^@ Function ^@ CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/273063:STK_RS02555 ^@ http://purl.uniprot.org/uniprot/Q975G6 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/273063:STK_RS02990 ^@ http://purl.uniprot.org/uniprot/Q974Y8 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer.|||Maximal activity at 95 Celsius degrees. http://togogenome.org/gene/273063:STK_RS06665 ^@ http://purl.uniprot.org/uniprot/F9VNX5 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/273063:STK_RS02715 ^@ http://purl.uniprot.org/uniprot/Q975D5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/273063:STK_RS02140 ^@ http://purl.uniprot.org/uniprot/Q975P6 ^@ Cofactor|||Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Binds two Mg(2+) per subunit.|||Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.|||In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.|||In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.|||Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.|||Monomer.|||This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures. http://togogenome.org/gene/273063:STK_RS04430 ^@ http://purl.uniprot.org/uniprot/Q973V2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS12000 ^@ http://purl.uniprot.org/uniprot/Q96YK0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer. http://togogenome.org/gene/273063:STK_RS13835 ^@ http://purl.uniprot.org/uniprot/Q96XJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Archaeal flagellum|||Belongs to the archaeal flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella. http://togogenome.org/gene/273063:STK_RS02450 ^@ http://purl.uniprot.org/uniprot/Q975I5 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/273063:STK_RS03065 ^@ http://purl.uniprot.org/uniprot/Q974X3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family.|||Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Carries out the first step of the leucine biosynthesis pathway.|||Homodimer. http://togogenome.org/gene/273063:STK_RS10115 ^@ http://purl.uniprot.org/uniprot/F9VNM6 ^@ Function|||Similarity ^@ Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.|||Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. http://togogenome.org/gene/273063:STK_RS01790 ^@ http://purl.uniprot.org/uniprot/F9VMT6 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the FBP aldolase/phosphatase family.|||Can also use Zn(2+) or Mn(2+) in vitro, although with much less efficiency than Mg(2+).|||Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).|||Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.|||Homooctamer; dimer of tetramers. http://togogenome.org/gene/273063:STK_RS02935 ^@ http://purl.uniprot.org/uniprot/Q974Z9 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity). http://togogenome.org/gene/273063:STK_RS04530 ^@ http://purl.uniprot.org/uniprot/Q973T6 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/273063:STK_RS06795 ^@ http://purl.uniprot.org/uniprot/Q971Z9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the anthranilate synthase component I family.|||Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).|||Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. http://togogenome.org/gene/273063:STK_RS04775 ^@ http://purl.uniprot.org/uniprot/Q973P1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS13645 ^@ http://purl.uniprot.org/uniprot/Q96XN6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS08220 ^@ http://purl.uniprot.org/uniprot/Q970Y4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/273063:STK_RS02350 ^@ http://purl.uniprot.org/uniprot/Q975K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS12955 ^@ http://purl.uniprot.org/uniprot/Q96Y18 ^@ Similarity ^@ Belongs to the DeoC/FbaB aldolase family. http://togogenome.org/gene/273063:STK_RS11655 ^@ http://purl.uniprot.org/uniprot/Q96YS0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/273063:STK_RS12410 ^@ http://purl.uniprot.org/uniprot/Q96YC3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS05180 ^@ http://purl.uniprot.org/uniprot/Q973G1 ^@ Function|||Similarity ^@ Belongs to the NOP10 family.|||Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. http://togogenome.org/gene/273063:STK_RS14115 ^@ http://purl.uniprot.org/uniprot/Q96XE0 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the zinc-containing alcohol dehydrogenase family.|||Binds 2 Zn(2+) ions per subunit.|||Homodimer and homotetramer. http://togogenome.org/gene/273063:STK_RS02165 ^@ http://purl.uniprot.org/uniprot/Q975P0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.|||Nucleus|||Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure. http://togogenome.org/gene/273063:STK_RS02735 ^@ http://purl.uniprot.org/uniprot/Q975D1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/273063:STK_RS08290 ^@ http://purl.uniprot.org/uniprot/Q970X1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer. http://togogenome.org/gene/273063:STK_RS02065 ^@ http://purl.uniprot.org/uniprot/Q975R0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the THI4 family.|||Homooctamer; tetramer of dimers.|||Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. http://togogenome.org/gene/273063:STK_RS02665 ^@ http://purl.uniprot.org/uniprot/Q975E5 ^@ Function ^@ Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA. http://togogenome.org/gene/273063:STK_RS08535 ^@ http://purl.uniprot.org/uniprot/Q970S3 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/273063:STK_RS02550 ^@ http://purl.uniprot.org/uniprot/Q975G7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. http://togogenome.org/gene/273063:STK_RS01740 ^@ http://purl.uniprot.org/uniprot/Q975W6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).|||Belongs to the TDD superfamily. TSR3 family.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS09695 ^@ http://purl.uniprot.org/uniprot/F9VNK3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS02025 ^@ http://purl.uniprot.org/uniprot/Q975R8 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/273063:STK_RS02725 ^@ http://purl.uniprot.org/uniprot/Q975D3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcS subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/273063:STK_RS12585 ^@ http://purl.uniprot.org/uniprot/Q96Y92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS05650 ^@ http://purl.uniprot.org/uniprot/Q972X2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS08465 ^@ http://purl.uniprot.org/uniprot/Q970T7 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/273063:STK_RS01600 ^@ http://purl.uniprot.org/uniprot/Q975Z3 ^@ Similarity ^@ Belongs to the HTP reductase family. http://togogenome.org/gene/273063:STK_RS11805 ^@ http://purl.uniprot.org/uniprot/Q96YN9 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the ferredoxin--NADP reductase type 2 family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/273063:STK_RS01935 ^@ http://purl.uniprot.org/uniprot/Q975T0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/273063:STK_RS02750 ^@ http://purl.uniprot.org/uniprot/Q975C8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the zinc-containing alcohol dehydrogenase family.|||Monomer.|||Plays a role in autotrophic carbon fixation via the 3-hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the acryloyl-CoA dependent NADPH oxidation and formation of propionyl-CoA. Inactive towards 3-hydroxypropionyl-CoA, NADH and crotonyl-CoA. http://togogenome.org/gene/273063:STK_RS05350 ^@ http://purl.uniprot.org/uniprot/Q973C8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also activates L-serine and transfers it to tRNA(Thr) but cannot deacylate incorrectly charged amino acid; unlike most archaea the editing function is found in a freestanding protein.|||Cytoplasm|||Homodimer (By similarity). Probably interacts with its editing subunit (By similarity). http://togogenome.org/gene/273063:STK_RS02480 ^@ http://purl.uniprot.org/uniprot/Q975H9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/273063:STK_RS01040 ^@ http://purl.uniprot.org/uniprot/Q976K3 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/273063:STK_RS02205 ^@ http://purl.uniprot.org/uniprot/Q975N2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). The trimeric complex inhibits DNA ligase and both 3'-5' and 5'-3' activity of Hel308 (Hjm) helicase, but stimulates Hjc, the Holliday junction cleavage enzyme.|||The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA (By similarity). Forms a dimeric complex with PCNA3 and a trimeric complex with PCNA2 and PCNA3; does not form homotrimers (PubMed:18782564). http://togogenome.org/gene/273063:STK_RS05175 ^@ http://purl.uniprot.org/uniprot/Q973G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/273063:STK_RS12615 ^@ http://purl.uniprot.org/uniprot/Q96Y87 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/273063:STK_RS06190 ^@ http://purl.uniprot.org/uniprot/F9VNV5 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/273063:STK_RS12570 ^@ http://purl.uniprot.org/uniprot/Q96Y96 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.|||Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).|||Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).|||Cytoplasm http://togogenome.org/gene/273063:STK_RS07690 ^@ http://purl.uniprot.org/uniprot/Q971I6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/273063:STK_RS01815 ^@ http://purl.uniprot.org/uniprot/O24735 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Forms a Heterooligomeric complex of two stacked nine-membered rings; one of alpha and the other of beta subunits.|||Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.|||The N-terminus is blocked. http://togogenome.org/gene/273063:STK_RS08850 ^@ http://purl.uniprot.org/uniprot/Q970L2 ^@ Similarity|||Subunit ^@ Belongs to the metallo-beta-lactamase superfamily.|||Monomer. http://togogenome.org/gene/273063:STK_RS13565 ^@ http://purl.uniprot.org/uniprot/Q96XQ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS01535 ^@ http://purl.uniprot.org/uniprot/Q976A6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.|||Part of the RNA polymerase complex. http://togogenome.org/gene/273063:STK_RS12820 ^@ http://purl.uniprot.org/uniprot/Q96Y44 ^@ Similarity ^@ Belongs to the UPF0282 family. http://togogenome.org/gene/273063:STK_RS02780 ^@ http://purl.uniprot.org/uniprot/F9VN03 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Homohexamer. Dimer of a homotrimer. http://togogenome.org/gene/273063:STK_RS10155 ^@ http://purl.uniprot.org/uniprot/Q96ZL7 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/273063:STK_RS13960 ^@ http://purl.uniprot.org/uniprot/Q96XG9 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family. http://togogenome.org/gene/273063:STK_RS05625 ^@ http://purl.uniprot.org/uniprot/Q972X7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS00890 ^@ http://purl.uniprot.org/uniprot/P55907 ^@ Cofactor|||Function ^@ Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Binds 1 zinc ion.|||Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/273063:STK_RS07805 ^@ http://purl.uniprot.org/uniprot/Q971G3 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs. http://togogenome.org/gene/273063:STK_RS04355 ^@ http://purl.uniprot.org/uniprot/Q973W5 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Plays a role in the autotrophic CO(2) fixation pathway. Activates 3-hydroxypropionate to its CoA ester. Can also activate propionate, and to a lesser extent acrylate, acetate and butyrate. http://togogenome.org/gene/273063:STK_RS05685 ^@ http://purl.uniprot.org/uniprot/Q972W5 ^@ Function|||Similarity ^@ Belongs to the cyanase family.|||Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. http://togogenome.org/gene/273063:STK_RS08320 ^@ http://purl.uniprot.org/uniprot/Q970W5 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/273063:STK_RS02390 ^@ http://purl.uniprot.org/uniprot/Q975J6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/273063:STK_RS03640 ^@ http://purl.uniprot.org/uniprot/Q974L3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS04835 ^@ http://purl.uniprot.org/uniprot/F9VNA8 ^@ Similarity ^@ Belongs to the WrbA family. http://togogenome.org/gene/273063:STK_RS12925 ^@ http://purl.uniprot.org/uniprot/F9VPE1 ^@ Caution|||Function|||Similarity ^@ Belongs to the CobB/CobQ family. CobQ subfamily.|||Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/273063:STK_RS01570 ^@ http://purl.uniprot.org/uniprot/Q975Z9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL24 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14. http://togogenome.org/gene/273063:STK_RS06785 ^@ http://purl.uniprot.org/uniprot/Q972A1 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/273063:STK_RS07765 ^@ http://purl.uniprot.org/uniprot/Q971H1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. http://togogenome.org/gene/273063:STK_RS10380 ^@ http://purl.uniprot.org/uniprot/Q96ZG9 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/273063:STK_RS06290 ^@ http://purl.uniprot.org/uniprot/F9VNW0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS09840 ^@ http://purl.uniprot.org/uniprot/Q96ZS8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS03030 ^@ http://purl.uniprot.org/uniprot/Q974Y0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/273063:STK_RS12575 ^@ http://purl.uniprot.org/uniprot/Q96Y95 ^@ Similarity ^@ Belongs to the shikimate dehydrogenase family. http://togogenome.org/gene/273063:STK_RS01200 ^@ http://purl.uniprot.org/uniprot/F9VMQ1 ^@ Similarity|||Subunit ^@ Belongs to the ALAD family.|||Homooctamer. http://togogenome.org/gene/273063:STK_RS08330 ^@ http://purl.uniprot.org/uniprot/Q970W3 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72. http://togogenome.org/gene/273063:STK_RS02335 ^@ http://purl.uniprot.org/uniprot/Q975K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 2 subfamily.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS11465 ^@ http://purl.uniprot.org/uniprot/Q96YV7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/273063:STK_RS07680 ^@ http://purl.uniprot.org/uniprot/Q971I8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. http://togogenome.org/gene/273063:STK_RS12540 ^@ http://purl.uniprot.org/uniprot/Q96YA2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS04630 ^@ http://purl.uniprot.org/uniprot/Q973R6 ^@ Function|||Similarity ^@ Belongs to the FAU-1 family.|||Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences. http://togogenome.org/gene/273063:STK_RS06860 ^@ http://purl.uniprot.org/uniprot/F9VNY7 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/273063:STK_RS03650 ^@ http://purl.uniprot.org/uniprot/Q974L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS05600 ^@ http://purl.uniprot.org/uniprot/Q972Y1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 38 family. http://togogenome.org/gene/273063:STK_RS11675 ^@ http://purl.uniprot.org/uniprot/Q96YR6 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the MRE11/RAD32 family.|||Binds 2 manganese ions per subunit.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits (By similarity). Interacts with HerA (PubMed:18243819).|||Nuclease activity is regulated by Rad50.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. http://togogenome.org/gene/273063:STK_RS01130 ^@ http://purl.uniprot.org/uniprot/F9VMP3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TPP enzyme family.|||Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/273063:STK_RS12865 ^@ http://purl.uniprot.org/uniprot/F9VPD8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/273063:STK_RS03940 ^@ http://purl.uniprot.org/uniprot/Q974E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/273063:STK_RS08020 ^@ http://purl.uniprot.org/uniprot/Q971C1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. http://togogenome.org/gene/273063:STK_RS12920 ^@ http://purl.uniprot.org/uniprot/Q96Y25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. http://togogenome.org/gene/273063:STK_RS11870 ^@ http://purl.uniprot.org/uniprot/F9VP97 ^@ Similarity ^@ Belongs to the AP endonuclease 2 family. http://togogenome.org/gene/273063:STK_RS03155 ^@ http://purl.uniprot.org/uniprot/Q974V5 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/273063:STK_RS08495 ^@ http://purl.uniprot.org/uniprot/Q970T1 ^@ Similarity ^@ Belongs to the transcriptional regulatory CopG/NikR family. http://togogenome.org/gene/273063:STK_RS09370 ^@ http://purl.uniprot.org/uniprot/Q970B4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS01065 ^@ http://purl.uniprot.org/uniprot/Q976J8 ^@ Function|||Miscellaneous|||PTM|||Subunit ^@ Binds zinc ions via its zinc finger domain, as shown by X-ray crystallography (PubMed:23434852). In contrast, the absorption spectrum of the ortholog from Thermophilus suggests that it may bind iron ions, possibly via the predicted zinc finger domain.|||Carrier protein that bears the covalently bound substrates for arginine and lysine biosynthesis; bound L-glutamate is sequentially converted to L-ornithine, while bound alpha-aminoadipate (AAA) is sequentially converted to L-lysine.|||Formation of an isopeptide bond between the gamma-carboxyl group of the C-terminal glutamate and the amino group of alpha-aminoadipate (AAA) is catalyzed by LysX. The bound AAA is then converted to L-lysine in a series of reactions catalyzed by LysZ, LysY and LysJ. Release of the product L-lysine is catalyzed by LysK. Formation of an isopeptide bond between the gamma-carboxyl group of the C-terminal glutamate and the amino group of L-glutamate is catalyzed by ArgX. The bound substrate is then sequentially converted to ornithine which is eventually converted to L-arginine (PubMed:23434852).|||Monomer. http://togogenome.org/gene/273063:STK_RS08055 ^@ http://purl.uniprot.org/uniprot/P62019 ^@ Caution|||Similarity|||Subunit ^@ Sul-ATPase is composed of six (or maybe five) subunits: alpha, beta, delta, gamma, C (proteolipid), and possibly epsilon.|||To E.hirae NtpH.|||Was originally reported as originating from S.acidocaldarius. http://togogenome.org/gene/273063:STK_RS07045 ^@ http://purl.uniprot.org/uniprot/Q971V1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the diphthine synthase family.|||Homodimer.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/273063:STK_RS02400 ^@ http://purl.uniprot.org/uniprot/Q975J4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/273063:STK_RS02590 ^@ http://purl.uniprot.org/uniprot/Q975F9 ^@ Activity Regulation|||Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Bifunctional enzyme involved in the synthesis of UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-N-acetylgalactosamine (UDP-GalNAc). It has multiple amino-sugar-1-phosphate acetyltransferase activities, including glucosamine-1-phosphate (GlcN-1-P) acetyltransferase and galactosamine-1-phosphate (GalN-1-P) acetyltransferase activities, and multiple sugar-1-phosphate nucleotidylyltransferase activities, including N-acetylglucosamine-1-phosphate (GlcNAc-1-P) uridyltransferase and N-acetylgalactosamine-1-phosphate (GalNAc-1-P) uridyltransferase activities (PubMed:15598657, PubMed:20400541, PubMed:25567746). Also catalyzes the formation of dTDP-glucose from dTTP and glucose-1-phosphate (Glc-1-P), and the reverse reaction, which produces dTTP from dTDP-glucose and diphosphate (PubMed:15598657). Can also catalyze the formation of UDP-glucose from UTP and glucose-1-phosphate (PubMed:27864169, PubMed:30291121).|||Can also use Mg(2+) and Zn(2+), with lower efficiency. Important for nucleotidylyltransferase activity.|||GlcN-1-P acetyltransferase activity is inhibited by divalent cations. GalN-1-P acetyltransferase activity is enhanced by Co(2+), Mg(2+) and Ca(2+), but inhibited by Zn(2+) or Mn(2+).|||Homotrimer.|||In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.|||The C-terminal domain is essential for the formation of the trimer and the high thermostability of the entire protein. The C-terminal 11 residues are important for GalN-1-P AcTase activity, but they have an inhibitory effect on the GlcN-1-P AcTase activity. http://togogenome.org/gene/273063:STK_RS03895 ^@ http://purl.uniprot.org/uniprot/Q974F7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS02435 ^@ http://purl.uniprot.org/uniprot/Q975I8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/273063:STK_RS00995 ^@ http://purl.uniprot.org/uniprot/Q976K8 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.|||Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. http://togogenome.org/gene/273063:STK_RS08190 ^@ http://purl.uniprot.org/uniprot/Q970Z0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). http://togogenome.org/gene/273063:STK_RS06950 ^@ http://purl.uniprot.org/uniprot/F9VNZ1 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase class-2 family.|||Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. http://togogenome.org/gene/273063:STK_RS12630 ^@ http://purl.uniprot.org/uniprot/Q96Y84 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/273063:STK_RS12965 ^@ http://purl.uniprot.org/uniprot/Q96Y16 ^@ Similarity ^@ Belongs to the UDPGP type 2 family. http://togogenome.org/gene/273063:STK_RS13865 ^@ http://purl.uniprot.org/uniprot/Q96XJ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS01060 ^@ http://purl.uniprot.org/uniprot/Q976J9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RimK family. LysX subfamily.|||Binds 2 magnesium ions per subunit.|||Catalyzes the ATP-dependent formation of a covalent bond between the amino group of alpha-aminoadipate (AAA) and the gamma-carboxyl group of the C-terminal glutamate residue in LysW.|||Homodimer. http://togogenome.org/gene/273063:STK_RS03915 ^@ http://purl.uniprot.org/uniprot/Q974F3 ^@ Function ^@ Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. http://togogenome.org/gene/273063:STK_RS00275 ^@ http://purl.uniprot.org/uniprot/Q976Z3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/273063:STK_RS07990 ^@ http://purl.uniprot.org/uniprot/F9VP58 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/273063:STK_RS11505 ^@ http://purl.uniprot.org/uniprot/Q96YU9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.|||Monomer.|||The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity. http://togogenome.org/gene/273063:STK_RS02185 ^@ http://purl.uniprot.org/uniprot/Q975N6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CbiX family. CbiXS subfamily.|||Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis.|||Homotetramer; dimer of dimers. http://togogenome.org/gene/273063:STK_RS05250 ^@ http://purl.uniprot.org/uniprot/Q973E7 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A single active site specifically recognizes both ATP and CTP and is responsible for their addition.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.|||Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.|||Homodimer. http://togogenome.org/gene/273063:STK_RS07560 ^@ http://purl.uniprot.org/uniprot/Q971K9 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.|||Specifically catalyzes the decarboxylation of L-arginine to agmatine. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity. http://togogenome.org/gene/273063:STK_RS01565 ^@ http://purl.uniprot.org/uniprot/Q976A0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/273063:STK_RS11645 ^@ http://purl.uniprot.org/uniprot/Q96YS2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PEPCase type 2 family.|||Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.|||Homotetramer. http://togogenome.org/gene/273063:STK_RS08335 ^@ http://purl.uniprot.org/uniprot/F9VNF3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/273063:STK_RS12960 ^@ http://purl.uniprot.org/uniprot/Q96Y17 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS06125 ^@ http://purl.uniprot.org/uniprot/Q972M6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS01585 ^@ http://purl.uniprot.org/uniprot/Q975Z6 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/273063:STK_RS10005 ^@ http://purl.uniprot.org/uniprot/F9VNM1 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/273063:STK_RS03145 ^@ http://purl.uniprot.org/uniprot/Q974V7 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/273063:STK_RS08210 ^@ http://purl.uniprot.org/uniprot/Q970Y6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRA-CH family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/273063:STK_RS12070 ^@ http://purl.uniprot.org/uniprot/Q96YI6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/273063:STK_RS07105 ^@ http://purl.uniprot.org/uniprot/Q971T8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity (By similarity).|||Belongs to the histone-like Alba family.|||Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes (By similarity).|||Chromosome|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/273063:STK_RS02250 ^@ http://purl.uniprot.org/uniprot/Q975M2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). Both trimeric complexes inhibit DNA ligase and both 3'-5' and 5'-3' activity of Hel308 (Hjm) helicase, but stimulate Hjc, the Holliday junction cleavage enzyme.|||The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA (By similarity). Forms a dimeric complex with PCNA3 and trimeric complexes PCNA123 and PCNA323; does not form homotrimers (PubMed:18782564). Crystal structures show a heterotetramer of 2 PCNA2 and 2 PCNA3, which would be large enough to clamp a Holliday junction (PubMed:21352919). http://togogenome.org/gene/273063:STK_RS01310 ^@ http://purl.uniprot.org/uniprot/Q976E9 ^@ Activity Regulation|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer. http://togogenome.org/gene/273063:STK_RS08185 ^@ http://purl.uniprot.org/uniprot/Q970Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS06720 ^@ http://purl.uniprot.org/uniprot/Q972B2 ^@ Similarity ^@ Belongs to the type IA topoisomerase family. http://togogenome.org/gene/273063:STK_RS11815 ^@ http://purl.uniprot.org/uniprot/Q96YN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. http://togogenome.org/gene/273063:STK_RS09995 ^@ http://purl.uniprot.org/uniprot/F9VNM0 ^@ Function|||Subunit ^@ Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/273063:STK_RS07150 ^@ http://purl.uniprot.org/uniprot/Q971T0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Cytoplasm|||Functions by promoting the formation of the first peptide bond. http://togogenome.org/gene/273063:STK_RS11855 ^@ http://purl.uniprot.org/uniprot/Q96YM7 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/273063:STK_RS07670 ^@ http://purl.uniprot.org/uniprot/Q971J0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/273063:STK_RS03040 ^@ http://purl.uniprot.org/uniprot/Q974X7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS03270 ^@ http://purl.uniprot.org/uniprot/Q974T4 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/273063:STK_RS08525 ^@ http://purl.uniprot.org/uniprot/Q970S5 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/273063:STK_RS02210 ^@ http://purl.uniprot.org/uniprot/Q975N0 ^@ Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the CobB/CbiA family.|||Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.|||Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.|||The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate. http://togogenome.org/gene/273063:STK_RS10025 ^@ http://purl.uniprot.org/uniprot/Q96ZP3 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/273063:STK_RS11765 ^@ http://purl.uniprot.org/uniprot/Q96YP8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the YjjX NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Homodimer.|||Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/273063:STK_RS10260 ^@ http://purl.uniprot.org/uniprot/Q96ZJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NrfD family.|||Membrane http://togogenome.org/gene/273063:STK_RS11435 ^@ http://purl.uniprot.org/uniprot/Q96YW3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/273063:STK_RS14490 ^@ http://purl.uniprot.org/uniprot/Q96X69 ^@ Function ^@ CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/273063:STK_RS08385 ^@ http://purl.uniprot.org/uniprot/Q970V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS07655 ^@ http://purl.uniprot.org/uniprot/F9VP34 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/273063:STK_RS10620 ^@ http://purl.uniprot.org/uniprot/Q96ZC0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcA family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||nucleolus http://togogenome.org/gene/273063:STK_RS11625 ^@ http://purl.uniprot.org/uniprot/F9VP86 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/273063:STK_RS10120 ^@ http://purl.uniprot.org/uniprot/Q96ZM3 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/273063:STK_RS02010 ^@ http://purl.uniprot.org/uniprot/Q975S1 ^@ Function|||Similarity ^@ Belongs to the TFIIB family.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/273063:STK_RS13275 ^@ http://purl.uniprot.org/uniprot/Q96XV7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS01510 ^@ http://purl.uniprot.org/uniprot/Q976B0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/273063:STK_RS13990 ^@ http://purl.uniprot.org/uniprot/Q96XG3 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/273063:STK_RS08265 ^@ http://purl.uniprot.org/uniprot/F9VNE9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/273063:STK_RS12515 ^@ http://purl.uniprot.org/uniprot/Q96YA6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSL4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. http://togogenome.org/gene/273063:STK_RS13740 ^@ http://purl.uniprot.org/uniprot/Q96XL5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/273063:STK_RS11240 ^@ http://purl.uniprot.org/uniprot/Q96Z02 ^@ Similarity ^@ Belongs to the esterase D family. http://togogenome.org/gene/273063:STK_RS09515 ^@ http://purl.uniprot.org/uniprot/Q96ZY7 ^@ Caution|||Function|||Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.|||Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/273063:STK_RS07140 ^@ http://purl.uniprot.org/uniprot/Q971T2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6B family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/273063:STK_RS02460 ^@ http://purl.uniprot.org/uniprot/Q975I3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29. http://togogenome.org/gene/273063:STK_RS02190 ^@ http://purl.uniprot.org/uniprot/Q975N5 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/273063:STK_RS13620 ^@ http://purl.uniprot.org/uniprot/Q96XP1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS12550 ^@ http://purl.uniprot.org/uniprot/Q96YA0 ^@ Function|||Subunit ^@ Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/273063:STK_RS01350 ^@ http://purl.uniprot.org/uniprot/Q976E1 ^@ Similarity ^@ Belongs to the UPF0210 family. http://togogenome.org/gene/273063:STK_RS00335 ^@ http://purl.uniprot.org/uniprot/Q976X8 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/273063:STK_RS12180 ^@ http://purl.uniprot.org/uniprot/Q96YG7 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/273063:STK_RS08980 ^@ http://purl.uniprot.org/uniprot/Q970I8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS11770 ^@ http://purl.uniprot.org/uniprot/Q96YP7 ^@ Caution|||Function|||Similarity ^@ Belongs to the MqnA/MqnD family. MqnD subfamily.|||Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/273063:STK_RS06730 ^@ http://purl.uniprot.org/uniprot/F9VNX9 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/273063:STK_RS04935 ^@ http://purl.uniprot.org/uniprot/F9VNB1 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/273063:STK_RS10520 ^@ http://purl.uniprot.org/uniprot/Q96ZD9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/273063:STK_RS03580 ^@ http://purl.uniprot.org/uniprot/Q974M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/273063:STK_RS03565 ^@ http://purl.uniprot.org/uniprot/Q974M6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sirtuin family. Class U subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. http://togogenome.org/gene/273063:STK_RS07600 ^@ http://purl.uniprot.org/uniprot/Q971K1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/273063:STK_RS09065 ^@ http://purl.uniprot.org/uniprot/F9VNH9 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/273063:STK_RS07775 ^@ http://purl.uniprot.org/uniprot/Q971G9 ^@ Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase I family.|||Toroid-shaped homodecamer, composed of two pentamers of five dimers. http://togogenome.org/gene/273063:STK_RS12580 ^@ http://purl.uniprot.org/uniprot/Q96Y94 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/273063:STK_RS12830 ^@ http://purl.uniprot.org/uniprot/F9VPD7 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/273063:STK_RS01195 ^@ http://purl.uniprot.org/uniprot/Q976H4 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/273063:STK_RS07970 ^@ http://purl.uniprot.org/uniprot/Q971D0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm http://togogenome.org/gene/273063:STK_RS10655 ^@ http://purl.uniprot.org/uniprot/Q96ZB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/273063:STK_RS10530 ^@ http://purl.uniprot.org/uniprot/Q96ZD7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/273063:STK_RS03970 ^@ http://purl.uniprot.org/uniprot/P58469 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/273063:STK_RS03020 ^@ http://purl.uniprot.org/uniprot/Q974Y2 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. PoK subfamily.|||Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway. http://togogenome.org/gene/273063:STK_RS12150 ^@ http://purl.uniprot.org/uniprot/F9VPA8 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/273063:STK_RS10105 ^@ http://purl.uniprot.org/uniprot/Q96ZM7 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/273063:STK_RS08350 ^@ http://purl.uniprot.org/uniprot/Q970V9 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/273063:STK_RS01170 ^@ http://purl.uniprot.org/uniprot/Q976H8 ^@ Function|||Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family.|||Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. http://togogenome.org/gene/273063:STK_RS13240 ^@ http://purl.uniprot.org/uniprot/Q96XW4 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/273063:STK_RS08470 ^@ http://purl.uniprot.org/uniprot/F9VNG3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/273063:STK_RS01295 ^@ http://purl.uniprot.org/uniprot/Q976F3 ^@ Function|||Similarity ^@ Belongs to the AdoMet synthase 2 family.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/273063:STK_RS02520 ^@ http://purl.uniprot.org/uniprot/Q975H2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity). http://togogenome.org/gene/273063:STK_RS06805 ^@ http://purl.uniprot.org/uniprot/Q971Z7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer. http://togogenome.org/gene/273063:STK_RS07650 ^@ http://purl.uniprot.org/uniprot/Q971J4 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS01210 ^@ http://purl.uniprot.org/uniprot/Q976H1 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/273063:STK_RS01835 ^@ http://purl.uniprot.org/uniprot/Q975U8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/273063:STK_RS11475 ^@ http://purl.uniprot.org/uniprot/Q96YV5 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/273063:STK_RS02930 ^@ http://purl.uniprot.org/uniprot/F9VN16 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/273063:STK_RS12815 ^@ http://purl.uniprot.org/uniprot/Q96Y45 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS01890 ^@ http://purl.uniprot.org/uniprot/Q975T7 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/273063:STK_RS07705 ^@ http://purl.uniprot.org/uniprot/Q971I2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family. http://togogenome.org/gene/273063:STK_RS03260 ^@ http://purl.uniprot.org/uniprot/Q974T6 ^@ Similarity ^@ Belongs to the RuvB family. http://togogenome.org/gene/273063:STK_RS02505 ^@ http://purl.uniprot.org/uniprot/Q975H5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).|||Cytoplasm http://togogenome.org/gene/273063:STK_RS12275 ^@ http://purl.uniprot.org/uniprot/Q96YE9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS02850 ^@ http://purl.uniprot.org/uniprot/F9VN10 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. http://togogenome.org/gene/273063:STK_RS13395 ^@ http://purl.uniprot.org/uniprot/Q96XT4 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 Mg(2+) per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/273063:STK_RS04080 ^@ http://purl.uniprot.org/uniprot/Q974C0 ^@ Cofactor|||Function|||Subunit ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer composed of an alpha and a beta subunit.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/273063:STK_RS02535 ^@ http://purl.uniprot.org/uniprot/Q975H0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/273063:STK_RS07965 ^@ http://purl.uniprot.org/uniprot/F9VP56 ^@ Function|||Similarity ^@ Belongs to the archaeal SPP-like hydrolase family.|||Catalyzes the dephosphorylation of 2-phosphoglycolate. http://togogenome.org/gene/273063:STK_RS08015 ^@ http://purl.uniprot.org/uniprot/Q971C2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. http://togogenome.org/gene/273063:STK_RS02430 ^@ http://purl.uniprot.org/uniprot/P60834 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/273063:STK_RS07060 ^@ http://purl.uniprot.org/uniprot/Q971U7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TYW1 family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).|||Cytoplasm|||Monomer. http://togogenome.org/gene/273063:STK_RS02465 ^@ http://purl.uniprot.org/uniprot/Q975I2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/273063:STK_RS02545 ^@ http://purl.uniprot.org/uniprot/Q975G8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp41 subfamily.|||Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteromeric RNA-tails.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS12525 ^@ http://purl.uniprot.org/uniprot/Q96YA4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/273063:STK_RS00295 ^@ http://purl.uniprot.org/uniprot/F9VMI9 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/273063:STK_RS10150 ^@ http://purl.uniprot.org/uniprot/F9VNM8 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/273063:STK_RS01435 ^@ http://purl.uniprot.org/uniprot/Q976C3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetyltransferase family. ARD1 subfamily.|||Cytoplasm|||Displays alpha (N-terminal) acetyltransferase activity. Catalyzes the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein.|||Homodimer.|||NAT does not require a binding partner for activity. http://togogenome.org/gene/273063:STK_RS09760 ^@ http://purl.uniprot.org/uniprot/Q96ZT9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS02895 ^@ http://purl.uniprot.org/uniprot/Q975A7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS01520 ^@ http://purl.uniprot.org/uniprot/Q976A8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Part of the 30S ribosomal subunit.|||With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. http://togogenome.org/gene/273063:STK_RS01735 ^@ http://purl.uniprot.org/uniprot/Q975W7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC61-beta family.|||Cell membrane|||Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer (By similarity).|||Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex (By similarity). http://togogenome.org/gene/273063:STK_RS08740 ^@ http://purl.uniprot.org/uniprot/Q970N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/273063:STK_RS03890 ^@ http://purl.uniprot.org/uniprot/Q974F8 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/273063:STK_RS00900 ^@ http://purl.uniprot.org/uniprot/Q976M5 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/273063:STK_RS01970 ^@ http://purl.uniprot.org/uniprot/Q975S6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA. http://togogenome.org/gene/273063:STK_RS05070 ^@ http://purl.uniprot.org/uniprot/Q973I4 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/273063:STK_RS01245 ^@ http://purl.uniprot.org/uniprot/Q976G4 ^@ Activity Regulation|||Function|||Similarity ^@ Belongs to the ATP-dependent DNA ligase family.|||DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.|||Inhibited by PCNA123 and PCNA323. http://togogenome.org/gene/273063:STK_RS04215 ^@ http://purl.uniprot.org/uniprot/Q973Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/273063:STK_RS12665 ^@ http://purl.uniprot.org/uniprot/Q96Y77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NucS endonuclease family.|||Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS04090 ^@ http://purl.uniprot.org/uniprot/F9VN77 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/273063:STK_RS01705 ^@ http://purl.uniprot.org/uniprot/Q975X3 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/273063:STK_RS03710 ^@ http://purl.uniprot.org/uniprot/Q974J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/273063:STK_RS08045 ^@ http://purl.uniprot.org/uniprot/Q971B6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.|||Sul-ATPase is composed of six (or maybe five) subunits: alpha, beta, delta, gamma, C (proteolipid), and possibly epsilon.|||Was originally reported as originating from S.acidocaldarius. http://togogenome.org/gene/273063:STK_RS01830 ^@ http://purl.uniprot.org/uniprot/Q975U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS12465 ^@ http://purl.uniprot.org/uniprot/Q96YB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CitM (TC 2.A.11) transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/273063:STK_RS02420 ^@ http://purl.uniprot.org/uniprot/Q975J0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges. http://togogenome.org/gene/273063:STK_RS11425 ^@ http://purl.uniprot.org/uniprot/Q96YW5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/273063:STK_RS11295 ^@ http://purl.uniprot.org/uniprot/Q96YZ1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DtxR/MntR family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/273063:STK_RS07940 ^@ http://purl.uniprot.org/uniprot/Q971D4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/273063:STK_RS08270 ^@ http://purl.uniprot.org/uniprot/Q970X5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. http://togogenome.org/gene/273063:STK_RS02070 ^@ http://purl.uniprot.org/uniprot/Q975Q9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/273063:STK_RS06610 ^@ http://purl.uniprot.org/uniprot/Q972D2 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.|||Binds 1 FAD per subunit.|||Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+) (PubMed:18226609, PubMed:23371294). Can also use L-asparagine, but not L-phenylalanine, L-glutamate, glycine, L-proline, L-alanine and D-aspartate (PubMed:23371294).|||Cytoplasm|||Folds into three domains: the FAD-binding domain, the capping domain and the C-terminal helical domain.|||Monomer. http://togogenome.org/gene/273063:STK_RS05690 ^@ http://purl.uniprot.org/uniprot/Q972W4 ^@ Similarity ^@ Belongs to the UreD family. http://togogenome.org/gene/273063:STK_RS09230 ^@ http://purl.uniprot.org/uniprot/Q970E1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS11680 ^@ http://purl.uniprot.org/uniprot/Q96YR5 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the SMC family. RAD50 subfamily.|||Binds 1 zinc ion per homodimer.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.|||The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer. http://togogenome.org/gene/273063:STK_RS02360 ^@ http://purl.uniprot.org/uniprot/Q975K2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/273063:STK_RS10135 ^@ http://purl.uniprot.org/uniprot/Q96ZM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).|||Cell membrane http://togogenome.org/gene/273063:STK_RS04505 ^@ http://purl.uniprot.org/uniprot/Q973U0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/273063:STK_RS10585 ^@ http://purl.uniprot.org/uniprot/Q96ZC6 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/273063:STK_RS07130 ^@ http://purl.uniprot.org/uniprot/Q971T4 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Monomer. http://togogenome.org/gene/273063:STK_RS06820 ^@ http://purl.uniprot.org/uniprot/Q971Z4 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/273063:STK_RS11460 ^@ http://purl.uniprot.org/uniprot/Q96YV8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/273063:STK_RS03325 ^@ http://purl.uniprot.org/uniprot/Q974S3 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Potential transporter for phosphate. http://togogenome.org/gene/273063:STK_RS00925 ^@ http://purl.uniprot.org/uniprot/Q976M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS00135 ^@ http://purl.uniprot.org/uniprot/F9VMH9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/273063:STK_RS02195 ^@ http://purl.uniprot.org/uniprot/Q975N4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeal MetE family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown. http://togogenome.org/gene/273063:STK_RS06555 ^@ http://purl.uniprot.org/uniprot/Q972E1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS10160 ^@ http://purl.uniprot.org/uniprot/Q96ZL5 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.|||Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. http://togogenome.org/gene/273063:STK_RS10090 ^@ http://purl.uniprot.org/uniprot/Q96ZN0 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/273063:STK_RS01260 ^@ http://purl.uniprot.org/uniprot/F9VMQ7 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/273063:STK_RS01055 ^@ http://purl.uniprot.org/uniprot/Q976K0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||Involved in both the arginine and lysine biosynthetic pathways. http://togogenome.org/gene/273063:STK_RS02790 ^@ http://purl.uniprot.org/uniprot/Q975C1 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/273063:STK_RS02235 ^@ http://purl.uniprot.org/uniprot/Q975M5 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/273063:STK_RS03430 ^@ http://purl.uniprot.org/uniprot/F9VN55 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/273063:STK_RS07585 ^@ http://purl.uniprot.org/uniprot/Q971K4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/273063:STK_RS08840 ^@ http://purl.uniprot.org/uniprot/Q970L4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS04575 ^@ http://purl.uniprot.org/uniprot/F9VN97 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/273063:STK_RS08565 ^@ http://purl.uniprot.org/uniprot/Q970R8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS12395 ^@ http://purl.uniprot.org/uniprot/Q96YC6 ^@ Similarity|||Subunit ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Homohexamer. http://togogenome.org/gene/273063:STK_RS06825 ^@ http://purl.uniprot.org/uniprot/Q971Z3 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/273063:STK_RS10345 ^@ http://purl.uniprot.org/uniprot/Q96ZH6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS02375 ^@ http://purl.uniprot.org/uniprot/Q975J9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/273063:STK_RS13635 ^@ http://purl.uniprot.org/uniprot/F9VPG1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DapA family. KDPG aldolase subfamily.|||Homotetramer; dimer of dimers.|||Involved in the degradation of glucose and galactose via the Entner-Doudoroff pathway. Catalyzes the reversible cleavage of 2-keto-3-deoxy-6-phosphogluconate (KDPG) and 2-keto-3-deoxygluconate (KDG) forming pyruvate and glyceraldehyde 3-phosphate or glyceraldehyde, respectively. It is also able to catalyze the reversible cleavage of 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) and 2-keto-3-deoxygalactonate (KDGal). http://togogenome.org/gene/273063:STK_RS12795 ^@ http://purl.uniprot.org/uniprot/Q96Y49 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/273063:STK_RS12930 ^@ http://purl.uniprot.org/uniprot/Q96Y23 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/273063:STK_RS05520 ^@ http://purl.uniprot.org/uniprot/Q972Z8 ^@ Subcellular Location Annotation ^@ Encapsulin nanocompartment http://togogenome.org/gene/273063:STK_RS03300 ^@ http://purl.uniprot.org/uniprot/Q974S8 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/273063:STK_RS10030 ^@ http://purl.uniprot.org/uniprot/F9VNM3 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/273063:STK_RS05860 ^@ http://purl.uniprot.org/uniprot/Q972S9 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/273063:STK_RS04185 ^@ http://purl.uniprot.org/uniprot/F9VN79 ^@ Cofactor|||Function|||Miscellaneous|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Divalent metal cations; Mn(2+) and Mg(2+) are preferred over Co(2+) or Ni(2+).|||Monomer.|||Nuclease that specifically degrades the RNA of RNA-DNA hybrids. Endonucleolytically removes RNA primers from the Okazaki fragments of lagging strand synthesis on its own. In the presence of Mn(2+) or Co(2+) can also cleave an RNA-RNA hybrid; the dsRNase activity is 10- 100-fold lower than RNase H activity. Complements the temperature-sensitive phenotype of an E.coli double rnhA/rnhB (RNase H) disruption mutant.|||The disulfide bond confers considerable stability to the protein.|||The protein is hyperthermostable, melting temperature (TM) for wild-type is 102 degrees Celsius, for the double Cys mutant is 93 degrees Celsius and for a C-terminal deletion of 6 residues is 77 degrees Celsius. http://togogenome.org/gene/273063:STK_RS11905 ^@ http://purl.uniprot.org/uniprot/Q96YL7 ^@ Function|||Similarity ^@ Belongs to the THEP1 NTPase family.|||Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency. http://togogenome.org/gene/273063:STK_RS06815 ^@ http://purl.uniprot.org/uniprot/Q971Z5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/273063:STK_RS07925 ^@ http://purl.uniprot.org/uniprot/Q971D8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/273063:STK_RS00960 ^@ http://purl.uniprot.org/uniprot/Q976L5 ^@ Function|||Similarity ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. http://togogenome.org/gene/273063:STK_RS11670 ^@ http://purl.uniprot.org/uniprot/Q96YR7 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ ATPase activity is slightly stimulated by either circular single- or double-stranded DNA with a weak preference for double-stranded DNA (PubMed:18243819). Helicase activity is stimulated by Mre11 (PubMed:18243819).|||Belongs to the HerA family.|||Forms a hexamer or a heptamer (PubMed:18243819). Interacts with Mre11 (PubMed:18243819).|||Involved in DNA double-strand break (DSB) repair (PubMed:18243819). Acts probably with NurA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity). Exhibits DNA-dependent ATPase activity and DNA helicase activity (PubMed:18243819). Loads on either a 3' or a 5' DNA tail for subsequent DNA unwinding (PubMed:18243819). Can also unwind blunt-ended dsDNA, Holliday junction and splayed-arm DNA (PubMed:18243819). http://togogenome.org/gene/273063:STK_RS12745 ^@ http://purl.uniprot.org/uniprot/Q96Y60 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Homodimer.|||Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. http://togogenome.org/gene/273063:STK_RS02015 ^@ http://purl.uniprot.org/uniprot/Q975S0 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/273063:STK_RS07675 ^@ http://purl.uniprot.org/uniprot/Q971I9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SPT5 family.|||Belongs to the archaeal Spt5 family.|||Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).|||Stimulates transcription elongation. http://togogenome.org/gene/273063:STK_RS08755 ^@ http://purl.uniprot.org/uniprot/Q970N1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/273063:STK_RS02385 ^@ http://purl.uniprot.org/uniprot/Q975J7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/273063:STK_RS08550 ^@ http://purl.uniprot.org/uniprot/F9VNG8 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/273063:STK_RS08375 ^@ http://purl.uniprot.org/uniprot/F9VNF7 ^@ Cofactor|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/273063:STK_RS03725 ^@ http://purl.uniprot.org/uniprot/Q974J4 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/273063:STK_RS03440 ^@ http://purl.uniprot.org/uniprot/Q974Q0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS02440 ^@ http://purl.uniprot.org/uniprot/Q975I7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/273063:STK_RS01500 ^@ http://purl.uniprot.org/uniprot/Q976B2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/273063:STK_RS07770 ^@ http://purl.uniprot.org/uniprot/F9VP42 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/273063:STK_RS08370 ^@ http://purl.uniprot.org/uniprot/F9VNF6 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/273063:STK_RS00965 ^@ http://purl.uniprot.org/uniprot/F9VMM8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS08625 ^@ http://purl.uniprot.org/uniprot/Q970Q8 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/273063:STK_RS08080 ^@ http://purl.uniprot.org/uniprot/Q971B2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/273063:STK_RS05710 ^@ http://purl.uniprot.org/uniprot/Q972W0 ^@ Cofactor|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.|||Binds 2 nickel ions per subunit.|||Carboxylation allows a single lysine to coordinate two nickel ions.|||Cytoplasm|||Heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta) subunits. http://togogenome.org/gene/273063:STK_RS13120 ^@ http://purl.uniprot.org/uniprot/Q96XY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/273063:STK_RS03150 ^@ http://purl.uniprot.org/uniprot/Q974V6 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/273063:STK_RS11400 ^@ http://purl.uniprot.org/uniprot/Q96YX1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS00410 ^@ http://purl.uniprot.org/uniprot/Q976W3 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/273063:STK_RS12915 ^@ http://purl.uniprot.org/uniprot/F9VPE0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobD/CbiB family.|||Cell membrane|||Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/273063:STK_RS07595 ^@ http://purl.uniprot.org/uniprot/Q971K2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/273063:STK_RS07085 ^@ http://purl.uniprot.org/uniprot/Q971U1 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/273063:STK_RS13895 ^@ http://purl.uniprot.org/uniprot/Q96XI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/273063:STK_RS06460 ^@ http://purl.uniprot.org/uniprot/Q972G5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S41B family.|||Cytoplasm|||Degrades oligopeptides in a sequential manner.|||Tricorn seems to be split into two ORFs in S.tokodaii, encoded on opposite strands and separated by approximately 279 kb. http://togogenome.org/gene/273063:STK_RS01155 ^@ http://purl.uniprot.org/uniprot/Q976I3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/273063:STK_RS05115 ^@ http://purl.uniprot.org/uniprot/Q973H3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/273063:STK_RS12245 ^@ http://purl.uniprot.org/uniprot/Q96YF5 ^@ Similarity ^@ Belongs to the complex I subunit 3 family. http://togogenome.org/gene/273063:STK_RS06670 ^@ http://purl.uniprot.org/uniprot/Q972C1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. N-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/273063:STK_RS06970 ^@ http://purl.uniprot.org/uniprot/Q971W5 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the asparaginase 1 family. GatD subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/273063:STK_RS02995 ^@ http://purl.uniprot.org/uniprot/Q974Y7 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/273063:STK_RS08620 ^@ http://purl.uniprot.org/uniprot/F9VNH0 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/273063:STK_RS05420 ^@ http://purl.uniprot.org/uniprot/F9VNS6 ^@ Similarity ^@ Belongs to the diphosphomevalonate decarboxylase family. http://togogenome.org/gene/273063:STK_RS01095 ^@ http://purl.uniprot.org/uniprot/F9VMN9 ^@ Similarity ^@ Belongs to the SIS family. PHI subfamily. http://togogenome.org/gene/273063:STK_RS01885 ^@ http://purl.uniprot.org/uniprot/Q975T8 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the TFE family.|||Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.|||The winged helix domain is involved in binding to DNA in the preinitiation complex.|||Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes. http://togogenome.org/gene/273063:STK_RS05235 ^@ http://purl.uniprot.org/uniprot/Q973F0 ^@ Similarity ^@ Belongs to the UPF0201 family. http://togogenome.org/gene/273063:STK_RS07565 ^@ http://purl.uniprot.org/uniprot/Q971K8 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. UPF0219 family. http://togogenome.org/gene/273063:STK_RS02500 ^@ http://purl.uniprot.org/uniprot/Q975H6 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/273063:STK_RS01530 ^@ http://purl.uniprot.org/uniprot/P58376 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/273063:STK_RS02130 ^@ http://purl.uniprot.org/uniprot/Q975P8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/273063:STK_RS12175 ^@ http://purl.uniprot.org/uniprot/Q96YG8 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/273063:STK_RS09380 ^@ http://purl.uniprot.org/uniprot/F9VNJ5 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/273063:STK_RS08560 ^@ http://purl.uniprot.org/uniprot/F9VNG9 ^@ Function|||Subunit ^@ Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/273063:STK_RS08250 ^@ http://purl.uniprot.org/uniprot/Q970X9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/273063:STK_RS04650 ^@ http://purl.uniprot.org/uniprot/Q973R2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane http://togogenome.org/gene/273063:STK_RS05090 ^@ http://purl.uniprot.org/uniprot/Q973H9 ^@ Function|||Similarity ^@ Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/273063:STK_RS12905 ^@ http://purl.uniprot.org/uniprot/Q96Y28 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/273063:STK_RS12510 ^@ http://purl.uniprot.org/uniprot/Q96YA7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/273063:STK_RS04895 ^@ http://purl.uniprot.org/uniprot/Q973L6 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/273063:STK_RS12710 ^@ http://purl.uniprot.org/uniprot/Q96Y68 ^@ Activity Regulation|||Cofactor|||Function|||Subunit ^@ Binds 1 Mg(2+) per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit.|||Inhibited by low concentration of 4-fluoro-7-nitrobenzofurazan (NBD-F). http://togogenome.org/gene/273063:STK_RS05990 ^@ http://purl.uniprot.org/uniprot/Q972Q3 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/273063:STK_RS03530 ^@ http://purl.uniprot.org/uniprot/Q974N3 ^@ Similarity ^@ Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. http://togogenome.org/gene/273063:STK_RS11255 ^@ http://purl.uniprot.org/uniprot/Q96YZ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homotetramer; dimer of dimers.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/273063:STK_RS08095 ^@ http://purl.uniprot.org/uniprot/Q971A9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. http://togogenome.org/gene/273063:STK_RS08105 ^@ http://purl.uniprot.org/uniprot/Q971A7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/273063:STK_RS10210 ^@ http://purl.uniprot.org/uniprot/Q96ZK3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS03525 ^@ http://purl.uniprot.org/uniprot/Q974N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS03905 ^@ http://purl.uniprot.org/uniprot/Q974F5 ^@ Similarity ^@ Belongs to the UPF0248 family. http://togogenome.org/gene/273063:STK_RS01975 ^@ http://purl.uniprot.org/uniprot/Q975S5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.|||Cytoplasm|||Homodimer or homotetramer. http://togogenome.org/gene/273063:STK_RS05355 ^@ http://purl.uniprot.org/uniprot/Q973C7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGMT family.|||Cytoplasm|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.|||This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. http://togogenome.org/gene/273063:STK_RS11395 ^@ http://purl.uniprot.org/uniprot/Q96YX2 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/273063:STK_RS11450 ^@ http://purl.uniprot.org/uniprot/Q96YW0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||Binds 1 [3Fe-4S] cluster.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex.|||X-ray crystallography in other archaea shows this protein binds a 3Fe-4S cluster, although a 4Fe-4S cluster has been suggested to be present in this protein. http://togogenome.org/gene/273063:STK_RS02020 ^@ http://purl.uniprot.org/uniprot/Q975R9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/273063:STK_RS00140 ^@ http://purl.uniprot.org/uniprot/Q977B7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/273063:STK_RS12555 ^@ http://purl.uniprot.org/uniprot/Q96Y99 ^@ Function|||Subunit ^@ Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/273063:STK_RS04195 ^@ http://purl.uniprot.org/uniprot/F9VN80 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS01635 ^@ http://purl.uniprot.org/uniprot/Q975Y7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/273063:STK_RS02175 ^@ http://purl.uniprot.org/uniprot/Q975N8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/273063:STK_RS08520 ^@ http://purl.uniprot.org/uniprot/Q970S6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SUA5 family.|||Cytoplasm|||Monomer.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity). Probably catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Shows ATP hydrolysis activity in vitro, producing AMP. http://togogenome.org/gene/273063:STK_RS01080 ^@ http://purl.uniprot.org/uniprot/Q976J5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.|||Cytoplasm|||Involved in both the arginine and lysine biosynthetic pathways. http://togogenome.org/gene/273063:STK_RS03315 ^@ http://purl.uniprot.org/uniprot/Q974S5 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/273063:STK_RS08125 ^@ http://purl.uniprot.org/uniprot/Q971A3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.|||Cell membrane|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/273063:STK_RS01285 ^@ http://purl.uniprot.org/uniprot/Q976F5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/273063:STK_RS02145 ^@ http://purl.uniprot.org/uniprot/F9VMV9 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/273063:STK_RS06220 ^@ http://purl.uniprot.org/uniprot/Q972K9 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.|||Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. http://togogenome.org/gene/273063:STK_RS08415 ^@ http://purl.uniprot.org/uniprot/Q970U7 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/273063:STK_RS06855 ^@ http://purl.uniprot.org/uniprot/Q971Y8 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/273063:STK_RS08555 ^@ http://purl.uniprot.org/uniprot/Q970S0 ^@ Function|||Subunit ^@ Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/273063:STK_RS03515 ^@ http://purl.uniprot.org/uniprot/Q974N6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS02605 ^@ http://purl.uniprot.org/uniprot/Q975F6 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/273063:STK_RS06810 ^@ http://purl.uniprot.org/uniprot/Q971Z6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/273063:STK_RS08195 ^@ http://purl.uniprot.org/uniprot/Q970Y9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. http://togogenome.org/gene/273063:STK_RS02610 ^@ http://purl.uniprot.org/uniprot/Q975F5 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/273063:STK_RS12995 ^@ http://purl.uniprot.org/uniprot/Q96Y10 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcA family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||nucleolus http://togogenome.org/gene/273063:STK_RS09225 ^@ http://purl.uniprot.org/uniprot/Q970E2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M32 family.|||Binds 1 zinc ion per subunit.|||Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. http://togogenome.org/gene/273063:STK_RS06965 ^@ http://purl.uniprot.org/uniprot/Q971W7 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the GatB/GatE family. GatE subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/273063:STK_RS03240 ^@ http://purl.uniprot.org/uniprot/Q974U1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS01655 ^@ http://purl.uniprot.org/uniprot/Q975Y3 ^@ Similarity ^@ Belongs to the serine/threonine dehydratase family. http://togogenome.org/gene/273063:STK_RS11230 ^@ http://purl.uniprot.org/uniprot/F9VP66 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/273063:STK_RS12260 ^@ http://purl.uniprot.org/uniprot/F9VPB4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS00640 ^@ http://purl.uniprot.org/uniprot/Q976R6 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/273063:STK_RS03380 ^@ http://purl.uniprot.org/uniprot/Q974R1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/273063:STK_RS07695 ^@ http://purl.uniprot.org/uniprot/Q971I5 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL20 family.|||Part of the 50S ribosomal subunit. Binds 23S rRNA. http://togogenome.org/gene/273063:STK_RS01250 ^@ http://purl.uniprot.org/uniprot/Q976G3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Catalyzes the deamination of dCTP to dUTP.|||Homotrimer. http://togogenome.org/gene/273063:STK_RS04015 ^@ http://purl.uniprot.org/uniprot/Q9HH83 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SDX family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Cytoplasm|||Homooligomeric.|||Not yet known. http://togogenome.org/gene/273063:STK_RS02320 ^@ http://purl.uniprot.org/uniprot/Q975L0 ^@ Function|||Similarity ^@ Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).|||Belongs to the archease family. http://togogenome.org/gene/273063:STK_RS08205 ^@ http://purl.uniprot.org/uniprot/Q970Y7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/273063:STK_RS03025 ^@ http://purl.uniprot.org/uniprot/Q974Y1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal phosphopantothenate synthetase family.|||Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.|||Homodimer. http://togogenome.org/gene/273063:STK_RS02410 ^@ http://purl.uniprot.org/uniprot/Q975J2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/273063:STK_RS02045 ^@ http://purl.uniprot.org/uniprot/Q975R4 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/273063:STK_RS12185 ^@ http://purl.uniprot.org/uniprot/Q96YG6 ^@ Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. http://togogenome.org/gene/273063:STK_RS02395 ^@ http://purl.uniprot.org/uniprot/Q975J5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/273063:STK_RS06185 ^@ http://purl.uniprot.org/uniprot/Q972L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/273063:STK_RS00430 ^@ http://purl.uniprot.org/uniprot/Q976V8 ^@ Similarity ^@ In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family. http://togogenome.org/gene/273063:STK_RS01545 ^@ http://purl.uniprot.org/uniprot/Q976A4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta chain family.|||Cytoplasm|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/273063:STK_RS07000 ^@ http://purl.uniprot.org/uniprot/Q971V9 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. http://togogenome.org/gene/273063:STK_RS05185 ^@ http://purl.uniprot.org/uniprot/Q973G0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-alpha family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/273063:STK_RS11275 ^@ http://purl.uniprot.org/uniprot/Q96YZ5 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily. http://togogenome.org/gene/273063:STK_RS01580 ^@ http://purl.uniprot.org/uniprot/Q975Z7 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/273063:STK_RS11970 ^@ http://purl.uniprot.org/uniprot/Q96YK6 ^@ Cofactor ^@ Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/273063:STK_RS07065 ^@ http://purl.uniprot.org/uniprot/Q971U6 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/273063:STK_RS04180 ^@ http://purl.uniprot.org/uniprot/Q973Z9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TPP enzyme family.|||Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/273063:STK_RS07930 ^@ http://purl.uniprot.org/uniprot/Q971D7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/273063:STK_RS05210 ^@ http://purl.uniprot.org/uniprot/Q973F5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). Both trimeric complexes inhibit DNA ligase and both 3'-5' and 5'-3' activity of Hel308 (Hjm) helicase, but stimulate Hjc, the Holliday junction cleavage enzyme.|||The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA (By similarity). Forms dimeric complexes with PCNA1 and PCNA2, and trimeric complexes with PCNA123 and PCNA323; does not form homotrimers (PubMed:18782564). Crystal structures show a heterotetramer of 2 PCNA2 and 2 PCNA3, which would be large enough to clamp a Holliday junction (PubMed:21352919). http://togogenome.org/gene/273063:STK_RS10795 ^@ http://purl.uniprot.org/uniprot/Q96Z87 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/273063:STK_RS14480 ^@ http://purl.uniprot.org/uniprot/Q96X73 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/273063:STK_RS02625 ^@ http://purl.uniprot.org/uniprot/Q975F2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/273063:STK_RS07975 ^@ http://purl.uniprot.org/uniprot/Q971C9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Cytoplasm|||Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.|||Part of the 50S ribosomal subunit. Probably part of the RNase P complex. http://togogenome.org/gene/273063:STK_RS00375 ^@ http://purl.uniprot.org/uniprot/F9VMJ3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/273063:STK_RS02365 ^@ http://purl.uniprot.org/uniprot/Q975K1 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/273063:STK_RS03385 ^@ http://purl.uniprot.org/uniprot/Q974R0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/273063:STK_RS08410 ^@ http://purl.uniprot.org/uniprot/Q970U8 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/273063:STK_RS01725 ^@ http://purl.uniprot.org/uniprot/F9VMT3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/273063:STK_RS07075 ^@ http://purl.uniprot.org/uniprot/Q971U3 ^@ Similarity ^@ Belongs to the CutA family. http://togogenome.org/gene/273063:STK_RS09915 ^@ http://purl.uniprot.org/uniprot/Q96ZR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS06735 ^@ http://purl.uniprot.org/uniprot/Q972A9 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/273063:STK_RS00595 ^@ http://purl.uniprot.org/uniprot/F9VMK8 ^@ Similarity ^@ Belongs to the malic enzymes family. http://togogenome.org/gene/273063:STK_RS03285 ^@ http://purl.uniprot.org/uniprot/Q974T1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endonuclease V family.|||Cytoplasm|||DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. http://togogenome.org/gene/273063:STK_RS10930 ^@ http://purl.uniprot.org/uniprot/Q96Z62 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.|||Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.|||Homodimer. http://togogenome.org/gene/273063:STK_RS05190 ^@ http://purl.uniprot.org/uniprot/Q973F9 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/273063:STK_RS02150 ^@ http://purl.uniprot.org/uniprot/Q975P3 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/273063:STK_RS04755 ^@ http://purl.uniprot.org/uniprot/Q973P6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS08010 ^@ http://purl.uniprot.org/uniprot/Q971C3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Binds 2 Mg(2+) or Mn(2+) ions per subunit.|||Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/273063:STK_RS02340 ^@ http://purl.uniprot.org/uniprot/Q975K6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/273063:STK_RS06740 ^@ http://purl.uniprot.org/uniprot/Q972A8 ^@ Function|||Similarity ^@ Belongs to the type-2 OGG1 family.|||Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites). http://togogenome.org/gene/273063:STK_RS10460 ^@ http://purl.uniprot.org/uniprot/F9VNN7 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/273063:STK_RS07915 ^@ http://purl.uniprot.org/uniprot/Q971E0 ^@ Similarity ^@ Belongs to the CinA family. http://togogenome.org/gene/273063:STK_RS10610 ^@ http://purl.uniprot.org/uniprot/F9VNP2 ^@ Cofactor|||Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/273063:STK_RS03280 ^@ http://purl.uniprot.org/uniprot/F9VN40 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/273063:STK_RS12715 ^@ http://purl.uniprot.org/uniprot/Q96Y66 ^@ Activity Regulation|||Domain|||Function|||Subunit ^@ Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit.|||Inhibited by low concentration of 4-fluoro-7-nitrobenzofurazan (NBD-F).|||The Tyr-Pro-Ile-Thr-Pro (YPITP) motif is important for the turnover of the reaction, presumably through its flexibility and mobility. http://togogenome.org/gene/273063:STK_RS13460 ^@ http://purl.uniprot.org/uniprot/Q96XS0 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/273063:STK_RS06295 ^@ http://purl.uniprot.org/uniprot/Q972J5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). http://togogenome.org/gene/273063:STK_RS06495 ^@ http://purl.uniprot.org/uniprot/P58331 ^@ Cofactor|||Function ^@ Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Binds 1 zinc ion.|||Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/273063:STK_RS11710 ^@ http://purl.uniprot.org/uniprot/Q96YQ9 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/273063:STK_RS12375 ^@ http://purl.uniprot.org/uniprot/Q96YD0 ^@ Function|||Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.|||Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP. http://togogenome.org/gene/273063:STK_RS10125 ^@ http://purl.uniprot.org/uniprot/P58407 ^@ Function|||Similarity ^@ Belongs to the LDH/MDH superfamily.|||Catalyzes the reversible oxidation of malate to oxaloacetate. http://togogenome.org/gene/273063:STK_RS01560 ^@ http://purl.uniprot.org/uniprot/Q976A1 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. http://togogenome.org/gene/273063:STK_RS08175 ^@ http://purl.uniprot.org/uniprot/Q970Z3 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family. Long subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Feedback inhibited by histidine. http://togogenome.org/gene/273063:STK_RS02695 ^@ http://purl.uniprot.org/uniprot/F9VMZ7 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/273063:STK_RS12595 ^@ http://purl.uniprot.org/uniprot/Q96Y90 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type-I 3-dehydroquinase family.|||Homodimer.|||Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. http://togogenome.org/gene/273063:STK_RS12240 ^@ http://purl.uniprot.org/uniprot/Q96YF6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the thymidylate synthase ThyX family.|||Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.|||Homotetramer. http://togogenome.org/gene/273063:STK_RS02270 ^@ http://purl.uniprot.org/uniprot/Q975L7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/273063:STK_RS11490 ^@ http://purl.uniprot.org/uniprot/Q96YV2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the archaeal DnaG primase family.|||Binds two Mg(2+) per subunit.|||Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome. http://togogenome.org/gene/273063:STK_RS13435 ^@ http://purl.uniprot.org/uniprot/Q96XS5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/273063:STK_RS08990 ^@ http://purl.uniprot.org/uniprot/Q970I7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS05410 ^@ http://purl.uniprot.org/uniprot/F9VNS5 ^@ Similarity ^@ Belongs to the PNP/UDP phosphorylase family. http://togogenome.org/gene/273063:STK_RS00440 ^@ http://purl.uniprot.org/uniprot/Q976V6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FdhD family.|||Cytoplasm|||Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. http://togogenome.org/gene/273063:STK_RS06800 ^@ http://purl.uniprot.org/uniprot/F9VNY3 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/273063:STK_RS07935 ^@ http://purl.uniprot.org/uniprot/Q971D5 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/273063:STK_RS05945 ^@ http://purl.uniprot.org/uniprot/F9VNU4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Homodimer.|||Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0). http://togogenome.org/gene/273063:STK_RS12195 ^@ http://purl.uniprot.org/uniprot/F9VPB1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS08430 ^@ http://purl.uniprot.org/uniprot/F9VNG2 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/273063:STK_RS10535 ^@ http://purl.uniprot.org/uniprot/Q96ZD6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/273063:STK_RS02080 ^@ http://purl.uniprot.org/uniprot/Q975Q7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. http://togogenome.org/gene/273063:STK_RS02975 ^@ http://purl.uniprot.org/uniprot/F9VN23 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS07710 ^@ http://purl.uniprot.org/uniprot/Q971I1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/273063:STK_RS03255 ^@ http://purl.uniprot.org/uniprot/Q974T7 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/273063:STK_RS03605 ^@ http://purl.uniprot.org/uniprot/Q96X56 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 7 kDa DNA-binding/endoribonuclease P2 family.|||Can constrain negative DNA supercoils. May be involved in maintaining the integrity of the genome at high temperature.|||Cytoplasm|||Monomer. http://togogenome.org/gene/273063:STK_RS02595 ^@ http://purl.uniprot.org/uniprot/Q975F8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS1 family. http://togogenome.org/gene/273063:STK_RS06915 ^@ http://purl.uniprot.org/uniprot/O24734 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Forms a Heterooligomeric complex of two stacked nine-membered rings; one of alpha and the other of beta subunits.|||Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. http://togogenome.org/gene/273063:STK_RS01525 ^@ http://purl.uniprot.org/uniprot/F9VMS0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NusA family.|||Cytoplasm|||Participates in transcription termination. http://togogenome.org/gene/273063:STK_RS13090 ^@ http://purl.uniprot.org/uniprot/Q96XZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/273063:STK_RS02965 ^@ http://purl.uniprot.org/uniprot/Q974Z3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/273063:STK_RS02445 ^@ http://purl.uniprot.org/uniprot/Q975I6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/273063:STK_RS08200 ^@ http://purl.uniprot.org/uniprot/Q970Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA-PH family.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS13930 ^@ http://purl.uniprot.org/uniprot/F9VPH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/273063:STK_RS10965 ^@ http://purl.uniprot.org/uniprot/Q96Z55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRISPR system Cmr5 family.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS13010 ^@ http://purl.uniprot.org/uniprot/Q96Y07 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS02355 ^@ http://purl.uniprot.org/uniprot/Q975K3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/273063:STK_RS08115 ^@ http://purl.uniprot.org/uniprot/Q971A5 ^@ Similarity ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. http://togogenome.org/gene/273063:STK_RS12520 ^@ http://purl.uniprot.org/uniprot/Q96YA5 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family.|||Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). http://togogenome.org/gene/273063:STK_RS01430 ^@ http://purl.uniprot.org/uniprot/F9VMR7 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/273063:STK_RS08060 ^@ http://purl.uniprot.org/uniprot/P62021 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Cell membrane|||Sul-ATPase is composed of six (or maybe five) subunits: alpha, beta, delta, gamma, C (proteolipid), and possibly epsilon.|||The C chain is a proteolipid, and one of the membranous subunits of the nonenzymatic component of the Sul-ATPase complex.|||Was originally reported as originating from S.acidocaldarius. http://togogenome.org/gene/273063:STK_RS08355 ^@ http://purl.uniprot.org/uniprot/F9VNF4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PurS family.|||Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/273063:STK_RS12500 ^@ http://purl.uniprot.org/uniprot/Q96YA8 ^@ Similarity ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. http://togogenome.org/gene/273063:STK_RS01550 ^@ http://purl.uniprot.org/uniprot/Q976A3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/273063:STK_RS07155 ^@ http://purl.uniprot.org/uniprot/Q971S9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/273063:STK_RS06115 ^@ http://purl.uniprot.org/uniprot/F9VNV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/273063:STK_RS07110 ^@ http://purl.uniprot.org/uniprot/Q971T7 ^@ Caution|||Cofactor|||Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Binds two Mg(2+) per subunit.|||Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.|||In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.|||In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.|||Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.|||Monomer.|||Ser-186 is present instead of the conserved Val which is part of the DDVD box.|||This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures. http://togogenome.org/gene/273063:STK_RS02470 ^@ http://purl.uniprot.org/uniprot/Q975I1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e. http://togogenome.org/gene/273063:STK_RS06985 ^@ http://purl.uniprot.org/uniprot/Q971W2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.|||Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. http://togogenome.org/gene/273063:STK_RS09275 ^@ http://purl.uniprot.org/uniprot/Q970D2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS11285 ^@ http://purl.uniprot.org/uniprot/Q96YZ3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the glycerate kinase type-1 family.|||Catalyzes the ATP-dependent phosphorylation of D-glycerate to 2-phosphoglycerate. It can also utilize GTP, CTP, UTP, ADP, AMP or pyrophosphate as phosphate donor.|||Homodimer.|||Magnesium. It could be replaced to some extent by nickel, manganese, cobalt, calcium, zinc or strontium. http://togogenome.org/gene/273063:STK_RS08280 ^@ http://purl.uniprot.org/uniprot/Q970X3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/273063:STK_RS04940 ^@ http://purl.uniprot.org/uniprot/Q973K8 ^@ Similarity ^@ Belongs to the peptidase C56 family. http://togogenome.org/gene/273063:STK_RS08030 ^@ http://purl.uniprot.org/uniprot/F9VNC4 ^@ Similarity ^@ Belongs to the V-ATPase F subunit family. http://togogenome.org/gene/273063:STK_RS02600 ^@ http://purl.uniprot.org/uniprot/Q975F7 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/273063:STK_RS03390 ^@ http://purl.uniprot.org/uniprot/Q974Q9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/273063:STK_RS10375 ^@ http://purl.uniprot.org/uniprot/Q96ZH0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. http://togogenome.org/gene/273063:STK_RS14080 ^@ http://purl.uniprot.org/uniprot/Q96XE7 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family. http://togogenome.org/gene/273063:STK_RS12075 ^@ http://purl.uniprot.org/uniprot/F9VPA4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/273063:STK_RS01850 ^@ http://purl.uniprot.org/uniprot/Q975U5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeosine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs. http://togogenome.org/gene/273063:STK_RS01505 ^@ http://purl.uniprot.org/uniprot/Q976B1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/273063:STK_RS08065 ^@ http://purl.uniprot.org/uniprot/Q971B5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/273063:STK_RS11745 ^@ http://purl.uniprot.org/uniprot/Q96YQ2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DtdA deacylase family.|||Binds 2 Zn(2+) ions per subunit.|||D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.|||Monomer. http://togogenome.org/gene/273063:STK_RS06835 ^@ http://purl.uniprot.org/uniprot/F9VNY5 ^@ Function|||Similarity ^@ Belongs to the PEP-utilizing enzyme family.|||Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. http://togogenome.org/gene/273063:STK_RS05195 ^@ http://purl.uniprot.org/uniprot/Q973F8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/273063:STK_RS08285 ^@ http://purl.uniprot.org/uniprot/Q970X2 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.|||Heterooligomer of catalytic and regulatory chains. http://togogenome.org/gene/273063:STK_RS06660 ^@ http://purl.uniprot.org/uniprot/Q972C3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/273063:STK_RS01145 ^@ http://purl.uniprot.org/uniprot/Q976I5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL40 family. http://togogenome.org/gene/273063:STK_RS05215 ^@ http://purl.uniprot.org/uniprot/Q973F4 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/273063:STK_RS02425 ^@ http://purl.uniprot.org/uniprot/Q975I9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/273063:STK_RS09240 ^@ http://purl.uniprot.org/uniprot/Q970D9 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/273063:STK_RS03790 ^@ http://purl.uniprot.org/uniprot/Q974I0 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/273063:STK_RS01795 ^@ http://purl.uniprot.org/uniprot/Q975V4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/273063:STK_RS04370 ^@ http://purl.uniprot.org/uniprot/Q973W2 ^@ Similarity ^@ Belongs to the HepT RNase toxin family. http://togogenome.org/gene/273063:STK_RS02380 ^@ http://purl.uniprot.org/uniprot/Q975J8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/273063:STK_RS10040 ^@ http://purl.uniprot.org/uniprot/F9VNM4 ^@ Similarity ^@ Belongs to the ETF alpha-subunit/FixB family. http://togogenome.org/gene/273063:STK_RS11900 ^@ http://purl.uniprot.org/uniprot/Q96YL8 ^@ Similarity ^@ Belongs to the BtpA family. http://togogenome.org/gene/273063:STK_RS07700 ^@ http://purl.uniprot.org/uniprot/Q971I4 ^@ Function|||Similarity ^@ Belongs to the eIF-6 family.|||Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. http://togogenome.org/gene/273063:STK_RS06675 ^@ http://purl.uniprot.org/uniprot/Q972C0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. C-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/273063:STK_RS12855 ^@ http://purl.uniprot.org/uniprot/Q96Y38 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/273063:STK_RS02680 ^@ http://purl.uniprot.org/uniprot/Q975E2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-archaeol synthase family.|||Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.|||Cell membrane http://togogenome.org/gene/273063:STK_RS12295 ^@ http://purl.uniprot.org/uniprot/Q96YE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity).|||Cytoplasm http://togogenome.org/gene/273063:STK_RS12590 ^@ http://purl.uniprot.org/uniprot/Q96Y91 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Monomer. http://togogenome.org/gene/273063:STK_RS11420 ^@ http://purl.uniprot.org/uniprot/Q96YW6 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/273063:STK_RS10785 ^@ http://purl.uniprot.org/uniprot/Q96Z89 ^@ Function|||Similarity ^@ Belongs to the UPF0330 family.|||Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC21 (Potential). http://togogenome.org/gene/273063:STK_RS00780 ^@ http://purl.uniprot.org/uniprot/Q976P1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS12935 ^@ http://purl.uniprot.org/uniprot/Q96Y22 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane http://togogenome.org/gene/273063:STK_RS02160 ^@ http://purl.uniprot.org/uniprot/Q975P1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt4 family.|||Heterodimer composed of Spt4 and Spt5.|||Stimulates transcription elongation. http://togogenome.org/gene/273063:STK_RS09470 ^@ http://purl.uniprot.org/uniprot/Q96ZZ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS11455 ^@ http://purl.uniprot.org/uniprot/Q96YV9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/273063:STK_RS11440 ^@ http://purl.uniprot.org/uniprot/Q96YW2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/273063:STK_RS11865 ^@ http://purl.uniprot.org/uniprot/Q96YM5 ^@ Function|||Similarity ^@ Belongs to the archaeal SPP-like hydrolase family.|||Catalyzes the dephosphorylation of 2-phosphoglycolate. http://togogenome.org/gene/273063:STK_RS06775 ^@ http://purl.uniprot.org/uniprot/Q972A3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/273063:STK_RS05850 ^@ http://purl.uniprot.org/uniprot/P58432 ^@ Similarity ^@ Belongs to the SfsA family. http://togogenome.org/gene/273063:STK_RS02050 ^@ http://purl.uniprot.org/uniprot/Q975R3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.|||Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.|||Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers. http://togogenome.org/gene/273063:STK_RS08040 ^@ http://purl.uniprot.org/uniprot/Q971B7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.|||Sul-ATPase is composed of six (or maybe five) subunits: alpha, beta, delta, gamma, C (proteolipid), and possibly epsilon.|||Was originally reported as originating from S.acidocaldarius. http://togogenome.org/gene/273063:STK_RS08365 ^@ http://purl.uniprot.org/uniprot/Q970V6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/273063:STK_RS14495 ^@ http://purl.uniprot.org/uniprot/Q96X68 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated protein Cas5 family. Subtype I-A/Apern subfamily.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/273063:STK_RS01165 ^@ http://purl.uniprot.org/uniprot/Q976I0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTH2 family.|||Cytoplasm|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/273063:STK_RS07175 ^@ http://purl.uniprot.org/uniprot/Q971S6 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP. http://togogenome.org/gene/273063:STK_RS11845 ^@ http://purl.uniprot.org/uniprot/Q96YM9 ^@ Similarity ^@ Belongs to the UPF0284 family. http://togogenome.org/gene/273063:STK_RS14370 ^@ http://purl.uniprot.org/uniprot/Q96X90 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/273063:STK_RS02560 ^@ http://purl.uniprot.org/uniprot/Q975G5 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/273063:STK_RS01345 ^@ http://purl.uniprot.org/uniprot/F9VMR2 ^@ Similarity ^@ Belongs to the UPF0237 family. http://togogenome.org/gene/273063:STK_RS01050 ^@ http://purl.uniprot.org/uniprot/Q976K1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family. LysK subfamily.|||Binds 2 Zn(2+) or Co(2+) ions per subunit.|||Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS00575 ^@ http://purl.uniprot.org/uniprot/F9VMK7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS01335 ^@ http://purl.uniprot.org/uniprot/Q976E4 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Involved in the synthesis of UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-N-acetylgalactosamine (UDP-GalNAc). Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate and of galactosamine-6-phosphate to galactosamine-1-phosphate. http://togogenome.org/gene/273063:STK_RS02455 ^@ http://purl.uniprot.org/uniprot/Q975I4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/273063:STK_RS03335 ^@ http://purl.uniprot.org/uniprot/Q974S1 ^@ Activity Regulation|||Domain|||Function|||Similarity|||Subunit ^@ An ATP, Mg(2+)-dependent DNA 3'-5' and 5'-3' helicase that may be involved in repair of stalled replication forks. Stimulated by both ss and dsDNA. Unwinds both leading and lagging strands in replication fork structures, unlike orthologs in P. furiosus and M. thermautotrophicus which only unwind the lagging strand and only have 3'-5' helicase activity. Preferentially binds dsDNA with overhangs or branched DNA. Able to anneal DNA substrates that could form a replication fork-like structure, has replication fork reversal activity (at least in vitro).|||Belongs to the helicase family. Hel308 subfamily.|||DNA-binding occurs via the first 2 N-terminal domains, which are also responsible for ATPase.|||Helicase activity is inhibited by Hjc (PubMed:18296528) and by PCNA123 and PCNA323 (PubMed:18782564).|||Monomer; forms a 1:2 complex with Hjc, which may form a complex with Holliday junction DNA.|||The C-terminal region (646-704) inhibits ATPase and helicase activity.|||The central region (432-645) which is structurally composed of 2 domains (432-500 and 501-645) is necessary for helicase activity. http://togogenome.org/gene/273063:STK_RS02415 ^@ http://purl.uniprot.org/uniprot/Q975J1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Located at the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/273063:STK_RS03360 ^@ http://purl.uniprot.org/uniprot/F9VN48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/273063:STK_RS07785 ^@ http://purl.uniprot.org/uniprot/F9VP44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamine synthetase family.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS11405 ^@ http://purl.uniprot.org/uniprot/F9VP77 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/273063:STK_RS08180 ^@ http://purl.uniprot.org/uniprot/Q970Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS02660 ^@ http://purl.uniprot.org/uniprot/Q975E6 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/273063:STK_RS11390 ^@ http://purl.uniprot.org/uniprot/Q96YX3 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/273063:STK_RS14475 ^@ http://purl.uniprot.org/uniprot/F9VPJ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/273063:STK_RS01070 ^@ http://purl.uniprot.org/uniprot/Q976J7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Homotetramer.|||In the absence or at low concentrations of lysine, activates the biosynthesis of this amino acid via the alpha-aminoadipate (AAA) pathway. http://togogenome.org/gene/273063:STK_RS02650 ^@ http://purl.uniprot.org/uniprot/Q975E9 ^@ Similarity ^@ Belongs to the UPF0147 family. http://togogenome.org/gene/273063:STK_RS06695 ^@ http://purl.uniprot.org/uniprot/Q972B6 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/273063:STK_RS09550 ^@ http://purl.uniprot.org/uniprot/Q96ZY0 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/273063:STK_RS09045 ^@ http://purl.uniprot.org/uniprot/Q970H8 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/273063:STK_RS04700 ^@ http://purl.uniprot.org/uniprot/Q973Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/273063:STK_RS11965 ^@ http://purl.uniprot.org/uniprot/Q96YK7 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/273063:STK_RS02540 ^@ http://purl.uniprot.org/uniprot/Q975G9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp42 subfamily.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. http://togogenome.org/gene/273063:STK_RS11430 ^@ http://purl.uniprot.org/uniprot/Q96YW4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/273063:STK_RS12205 ^@ http://purl.uniprot.org/uniprot/Q96YG3 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/273063:STK_RS06375 ^@ http://purl.uniprot.org/uniprot/Q972I2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Binds 1 heme group per subunit.|||Cytoplasm http://togogenome.org/gene/273063:STK_RS06780 ^@ http://purl.uniprot.org/uniprot/Q972A2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/273063:STK_RS05010 ^@ http://purl.uniprot.org/uniprot/Q973J4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS01575 ^@ http://purl.uniprot.org/uniprot/Q975Z8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/273063:STK_RS11495 ^@ http://purl.uniprot.org/uniprot/F9VP80 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/273063:STK_RS13870 ^@ http://purl.uniprot.org/uniprot/F9VPH0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/273063:STK_RS10205 ^@ http://purl.uniprot.org/uniprot/Q96ZK5 ^@ Similarity ^@ Belongs to the UPF0273 family. http://togogenome.org/gene/273063:STK_RS13270 ^@ http://purl.uniprot.org/uniprot/Q96XV8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TPP enzyme family.|||Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/273063:STK_RS04300 ^@ http://purl.uniprot.org/uniprot/Q973X5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/273063:STK_RS01960 ^@ http://purl.uniprot.org/uniprot/P58460 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycerol-1-phosphate dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/273063:STK_RS02240 ^@ http://purl.uniprot.org/uniprot/Q975M4 ^@ Function|||Similarity ^@ Belongs to the archaeal-type GTP cyclohydrolase family.|||Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity. http://togogenome.org/gene/273063:STK_RS13195 ^@ http://purl.uniprot.org/uniprot/Q96XX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Membrane http://togogenome.org/gene/273063:STK_RS02580 ^@ http://purl.uniprot.org/uniprot/Q975G1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/273063:STK_RS14065 ^@ http://purl.uniprot.org/uniprot/F9VPH9 ^@ Function ^@ Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor. http://togogenome.org/gene/273063:STK_RS11445 ^@ http://purl.uniprot.org/uniprot/Q96YW1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/273063:STK_RS01625 ^@ http://purl.uniprot.org/uniprot/Q975Y9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. http://togogenome.org/gene/273063:STK_RS07135 ^@ http://purl.uniprot.org/uniprot/Q971T3 ^@ Function|||Similarity ^@ Belongs to the deoxyhypusine synthase family.|||Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. http://togogenome.org/gene/273063:STK_RS08090 ^@ http://purl.uniprot.org/uniprot/F9VND5 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subunit ^@ A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products. Inhibits the helicase activity of Hel308 (Hjm).|||Belongs to the Holliday junction resolvase Hjc family.|||Binds 1 Mg(2+) ion per subunit.|||Cleavage stimulated by PCNA123 and PCNA323 (PubMed:18782564) and by RadC2 (PubMed:22437993).|||Homodimer; forms a 2:1 complex with Hel308 (Hjm). May form a complex with Holliday junction DNA, Hjc and Hjm. http://togogenome.org/gene/273063:STK_RS00555 ^@ http://purl.uniprot.org/uniprot/F9VMK5 ^@ Similarity ^@ Belongs to the cytochrome c oxidase subunit 2 family. http://togogenome.org/gene/273063:STK_RS07145 ^@ http://purl.uniprot.org/uniprot/Q971T1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6A family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/273063:STK_RS03250 ^@ http://purl.uniprot.org/uniprot/Q974T8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the DNA polymerase type-Y family.|||Binds 2 magnesium ions per subunit.|||Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. http://togogenome.org/gene/273063:STK_RS11610 ^@ http://purl.uniprot.org/uniprot/Q96X56 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 7 kDa DNA-binding/endoribonuclease P2 family.|||Can constrain negative DNA supercoils. May be involved in maintaining the integrity of the genome at high temperature.|||Cytoplasm|||Monomer. http://togogenome.org/gene/273063:STK_RS04500 ^@ http://purl.uniprot.org/uniprot/Q973U1 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/273063:STK_RS06165 ^@ http://purl.uniprot.org/uniprot/Q972L8 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/273063:STK_RS13630 ^@ http://purl.uniprot.org/uniprot/Q96XN9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the carbohydrate kinase PfkB family.|||Homotetramer.|||Involved in the degradation of glucose via the semi-phosphorylative Entner-Doudoroff pathway. Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). Can also use GTP, but not ADP or AMP, as a phosphoryl donor and 2-keto-D-gluconate (KG) as a phosphoryl acceptor.|||Mg(2+) is the most effective ion, but it can be replaced with Co(2+), Ni(2+), Zn(2+) or Mn(2+). http://togogenome.org/gene/273063:STK_RS12365 ^@ http://purl.uniprot.org/uniprot/Q96YD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/273063:STK_RS01540 ^@ http://purl.uniprot.org/uniprot/F9VMS2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds at least 2 Zn(2+) per subunit.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/273063:STK_RS08400 ^@ http://purl.uniprot.org/uniprot/Q970V0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/273063:STK_RS06425 ^@ http://purl.uniprot.org/uniprot/Q972H0 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/273063:STK_RS05220 ^@ http://purl.uniprot.org/uniprot/Q973F3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/273063:STK_RS07115 ^@ http://purl.uniprot.org/uniprot/Q971T6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity (By similarity).|||Belongs to the histone-like Alba family.|||Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes (By similarity).|||Chromosome|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/273063:STK_RS14175 ^@ http://purl.uniprot.org/uniprot/F9VPI2 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/273063:STK_RS13410 ^@ http://purl.uniprot.org/uniprot/Q96XS9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS07820 ^@ http://purl.uniprot.org/uniprot/Q971G0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 'phage' integrase family. XerA subfamily.|||Cytoplasm|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. http://togogenome.org/gene/273063:STK_RS02370 ^@ http://purl.uniprot.org/uniprot/Q975K0 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Part of the 30S ribosomal subunit. Contacts protein S4.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/273063:STK_RS11225 ^@ http://purl.uniprot.org/uniprot/F9VP65 ^@ Similarity ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. http://togogenome.org/gene/273063:STK_RS02180 ^@ http://purl.uniprot.org/uniprot/Q975N7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/273063:STK_RS08420 ^@ http://purl.uniprot.org/uniprot/Q970U6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RimK family. LysX subfamily.|||Binds 2 magnesium ions per subunit.|||Catalyzes the ATP-dependent formation of a covalent bond between the amino group of glutamate and the gamma-carboxyl group of the C-terminal glutamate residue in LysW.|||Homotetramer. Interacts with LysW. http://togogenome.org/gene/273063:STK_RS01075 ^@ http://purl.uniprot.org/uniprot/Q976J6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. LysZ subfamily.|||Cytoplasm|||Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis). http://togogenome.org/gene/273063:STK_RS07580 ^@ http://purl.uniprot.org/uniprot/F9VP30 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/273063:STK_RS05490 ^@ http://purl.uniprot.org/uniprot/Q973A3 ^@ Caution|||Function|||Similarity ^@ Belongs to the Nre family.|||Involved in DNA damage repair.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/273063:STK_RS11785 ^@ http://purl.uniprot.org/uniprot/Q96YP4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.|||Homodimer.|||Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. http://togogenome.org/gene/273063:STK_RS03095 ^@ http://purl.uniprot.org/uniprot/F9VN30 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/273063:STK_RS01965 ^@ http://purl.uniprot.org/uniprot/Q975S7 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/273063:STK_RS02090 ^@ http://purl.uniprot.org/uniprot/F9VMV5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/273063:STK_RS02720 ^@ http://purl.uniprot.org/uniprot/Q975D4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcL subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/273063:STK_RS09685 ^@ http://purl.uniprot.org/uniprot/Q96ZV1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/273063:STK_RS03845 ^@ http://purl.uniprot.org/uniprot/Q974G8 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/273063:STK_RS08050 ^@ http://purl.uniprot.org/uniprot/P62017 ^@ Caution|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane.|||Sul-ATPase is composed of six (or maybe five) subunits: alpha, beta, delta, gamma, C (proteolipid), and possibly epsilon.|||The N-terminus is blocked.|||Was originally reported as originating from S.acidocaldarius.