http://togogenome.org/gene/28377:LOC100567184 ^@ http://purl.uniprot.org/uniprot/A0A803TQW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:mab21l1 ^@ http://purl.uniprot.org/uniprot/G1KCK2 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/28377:xrcc4 ^@ http://purl.uniprot.org/uniprot/G1KKY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XRCC4 subfamily.|||Nucleus http://togogenome.org/gene/28377:drd1 ^@ http://purl.uniprot.org/uniprot/G1KQJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:abi1 ^@ http://purl.uniprot.org/uniprot/A0A803SQC5|||http://purl.uniprot.org/uniprot/A0A803T6L1|||http://purl.uniprot.org/uniprot/G1KHE5|||http://purl.uniprot.org/uniprot/G1KUV5 ^@ Similarity ^@ Belongs to the ABI family. http://togogenome.org/gene/28377:akap8l ^@ http://purl.uniprot.org/uniprot/G1KTQ8 ^@ Similarity ^@ Belongs to the AKAP95 family. http://togogenome.org/gene/28377:vsx2 ^@ http://purl.uniprot.org/uniprot/G1KSG9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:ucma ^@ http://purl.uniprot.org/uniprot/G1K954 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UCMA family.|||May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.|||extracellular matrix http://togogenome.org/gene/28377:lpcat1 ^@ http://purl.uniprot.org/uniprot/G1K8X6 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/28377:c7 ^@ http://purl.uniprot.org/uniprot/G1KJY2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:fam120b ^@ http://purl.uniprot.org/uniprot/G1KB05 ^@ Similarity ^@ Belongs to the constitutive coactivator of PPAR-gamma family. http://togogenome.org/gene/28377:dcbld1 ^@ http://purl.uniprot.org/uniprot/G1KPP2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:pmp22 ^@ http://purl.uniprot.org/uniprot/A0A803T054 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Might be involved in growth regulation, and in myelinization in the peripheral nervous system. http://togogenome.org/gene/28377:hnrnpdl ^@ http://purl.uniprot.org/uniprot/G1KK24 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/28377:nol10 ^@ http://purl.uniprot.org/uniprot/G1KMW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat NOL10/ENP2 family.|||nucleolus http://togogenome.org/gene/28377:ppil3 ^@ http://purl.uniprot.org/uniprot/G1KTF5 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/28377:alg10 ^@ http://purl.uniprot.org/uniprot/A0A803TBB7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG10 glucosyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:lrrc8d ^@ http://purl.uniprot.org/uniprot/G1KUQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100564911 ^@ http://purl.uniprot.org/uniprot/G1K9V7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/28377:ldlr ^@ http://purl.uniprot.org/uniprot/G1KSU0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:LOC100566106 ^@ http://purl.uniprot.org/uniprot/A0A803T1V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/28377:got1 ^@ http://purl.uniprot.org/uniprot/G1KC46 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/28377:mlh3 ^@ http://purl.uniprot.org/uniprot/A0A803T4A0|||http://purl.uniprot.org/uniprot/G1KT63 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/28377:cpne8 ^@ http://purl.uniprot.org/uniprot/G1KH50 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/28377:bak1 ^@ http://purl.uniprot.org/uniprot/G1KSN2 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/28377:chst9 ^@ http://purl.uniprot.org/uniprot/G1KAC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:tbxas1 ^@ http://purl.uniprot.org/uniprot/G1KTB2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/28377:cecr1 ^@ http://purl.uniprot.org/uniprot/G1KM25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.|||Secreted http://togogenome.org/gene/28377:pigp ^@ http://purl.uniprot.org/uniprot/G1KI81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGP family.|||Membrane|||Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. http://togogenome.org/gene/28377:mri1 ^@ http://purl.uniprot.org/uniprot/G1KBX7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:LOC100563415 ^@ http://purl.uniprot.org/uniprot/H9GUC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/28377:slc45a4 ^@ http://purl.uniprot.org/uniprot/G1K8N7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:slc16a4 ^@ http://purl.uniprot.org/uniprot/A0A803SZH6|||http://purl.uniprot.org/uniprot/G1KMT8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:ascc3 ^@ http://purl.uniprot.org/uniprot/G1KJW3 ^@ Similarity ^@ Belongs to the helicase family. http://togogenome.org/gene/28377:LOC100551718 ^@ http://purl.uniprot.org/uniprot/R4GDH8 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/28377:mff ^@ http://purl.uniprot.org/uniprot/A0A803SS56|||http://purl.uniprot.org/uniprot/G1KCL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tango11 family.|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. http://togogenome.org/gene/28377:h3f3b ^@ http://purl.uniprot.org/uniprot/G1KGC9 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/28377:strn ^@ http://purl.uniprot.org/uniprot/A0A803TJS2|||http://purl.uniprot.org/uniprot/R4GDF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat striatin family.|||Membrane http://togogenome.org/gene/28377:rpl27a ^@ http://purl.uniprot.org/uniprot/G1KJK2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/28377:usp15 ^@ http://purl.uniprot.org/uniprot/A0A803TDV1|||http://purl.uniprot.org/uniprot/G1K9E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:fga ^@ http://purl.uniprot.org/uniprot/G1KRE2 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/28377:mettl10 ^@ http://purl.uniprot.org/uniprot/A0A803SMA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.|||Cytoplasm|||Nucleus|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'. http://togogenome.org/gene/28377:ptx3 ^@ http://purl.uniprot.org/uniprot/A0A803SRQ9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:LOC100556565 ^@ http://purl.uniprot.org/uniprot/A0A803T3D9|||http://purl.uniprot.org/uniprot/G1KCF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome b5 family.|||Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||Endoplasmic reticulum http://togogenome.org/gene/28377:cpt1c ^@ http://purl.uniprot.org/uniprot/G1KP61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/28377:phospho1 ^@ http://purl.uniprot.org/uniprot/G1KEZ8|||http://purl.uniprot.org/uniprot/R4GAZ4 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/28377:arhgef3 ^@ http://purl.uniprot.org/uniprot/A0A803TZP1 ^@ Function|||Subcellular Location Annotation ^@ Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.|||Cytoplasm http://togogenome.org/gene/28377:pcnp ^@ http://purl.uniprot.org/uniprot/G1KLM9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with UHRF2/NIRF.|||May be involved in cell cycle regulation.|||Nucleus http://togogenome.org/gene/28377:dynlrb1 ^@ http://purl.uniprot.org/uniprot/A0A803U0H9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||cytoskeleton http://togogenome.org/gene/28377:LOC100555460 ^@ http://purl.uniprot.org/uniprot/G1KG29 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/28377:mrpl19 ^@ http://purl.uniprot.org/uniprot/A0A803TTE4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family. http://togogenome.org/gene/28377:LOC100559647 ^@ http://purl.uniprot.org/uniprot/R4GBC1 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.|||Homotetramer. http://togogenome.org/gene/28377:cldn24 ^@ http://purl.uniprot.org/uniprot/G1KUS2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/28377:cpt2 ^@ http://purl.uniprot.org/uniprot/G1KI37 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/28377:akap5 ^@ http://purl.uniprot.org/uniprot/G1KXM8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:gdf6 ^@ http://purl.uniprot.org/uniprot/R4GCR5 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/28377:kcne2 ^@ http://purl.uniprot.org/uniprot/A0A803SXX4 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/28377:slc37a1 ^@ http://purl.uniprot.org/uniprot/G1KBB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/28377:parp3 ^@ http://purl.uniprot.org/uniprot/G1KLC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARTD/PARP family.|||Nucleus http://togogenome.org/gene/28377:prdm4 ^@ http://purl.uniprot.org/uniprot/A0A803SVX3|||http://purl.uniprot.org/uniprot/A0A803T0L2|||http://purl.uniprot.org/uniprot/A0A803TTV5 ^@ Function|||Subcellular Location Annotation ^@ May function as a transcription factor involved in cell differentiation.|||Nucleus http://togogenome.org/gene/28377:tysnd1 ^@ http://purl.uniprot.org/uniprot/G1K9F7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1B family.|||Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.|||Peroxisome|||The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity. http://togogenome.org/gene/28377:rell2 ^@ http://purl.uniprot.org/uniprot/A0A803TH65|||http://purl.uniprot.org/uniprot/G1KLH2 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/28377:tyro3 ^@ http://purl.uniprot.org/uniprot/G1KPQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Membrane http://togogenome.org/gene/28377:lpgat1 ^@ http://purl.uniprot.org/uniprot/A0A803TFS3 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/28377:tmem63a ^@ http://purl.uniprot.org/uniprot/G1KEV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/28377:kcnv1 ^@ http://purl.uniprot.org/uniprot/G1KAW2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.|||Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.|||Membrane|||Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. http://togogenome.org/gene/28377:dbt ^@ http://purl.uniprot.org/uniprot/R4GCR7 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/28377:pex6 ^@ http://purl.uniprot.org/uniprot/G1KED1 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/28377:bod1 ^@ http://purl.uniprot.org/uniprot/G1KQN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BOD1 family.|||centrosome|||kinetochore http://togogenome.org/gene/28377:wtap ^@ http://purl.uniprot.org/uniprot/G1KCU9 ^@ Similarity ^@ Belongs to the fl(2)d family. http://togogenome.org/gene/28377:LOC100564704 ^@ http://purl.uniprot.org/uniprot/G1KB50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/28377:psma7 ^@ http://purl.uniprot.org/uniprot/G1KS92 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/28377:LOC100562810 ^@ http://purl.uniprot.org/uniprot/G1KAS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/28377:bysl ^@ http://purl.uniprot.org/uniprot/G1KBH5 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/28377:bpgm ^@ http://purl.uniprot.org/uniprot/A0A803TA28 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/28377:wdfy2 ^@ http://purl.uniprot.org/uniprot/G1KLW1 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/28377:synj1 ^@ http://purl.uniprot.org/uniprot/A0A803SUB3|||http://purl.uniprot.org/uniprot/A0A803TUK8 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/28377:phf5a ^@ http://purl.uniprot.org/uniprot/G1KD50 ^@ Similarity ^@ Belongs to the PHF5 family. http://togogenome.org/gene/28377:nmt2 ^@ http://purl.uniprot.org/uniprot/G1KSL0 ^@ Function|||Similarity ^@ Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.|||Belongs to the NMT family. http://togogenome.org/gene/28377:smad2 ^@ http://purl.uniprot.org/uniprot/A0A803SMT4|||http://purl.uniprot.org/uniprot/G1KUM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:tph1 ^@ http://purl.uniprot.org/uniprot/G1K884 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/28377:hmgcs1 ^@ http://purl.uniprot.org/uniprot/A0A803T0X4 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/28377:LOC100567205 ^@ http://purl.uniprot.org/uniprot/H9GFJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/28377:borcs7 ^@ http://purl.uniprot.org/uniprot/A0A803T8T0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS7 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/28377:col18a1 ^@ http://purl.uniprot.org/uniprot/A0A803T999 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:casp6 ^@ http://purl.uniprot.org/uniprot/G1KMX0 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/28377:chmp2b ^@ http://purl.uniprot.org/uniprot/A0A803SQP3 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/28377:kiaa1429 ^@ http://purl.uniprot.org/uniprot/G1KC69 ^@ Similarity ^@ Belongs to the vir family. http://togogenome.org/gene/28377:cacybp ^@ http://purl.uniprot.org/uniprot/G1KQM7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).|||Nucleus http://togogenome.org/gene/28377:hpgd ^@ http://purl.uniprot.org/uniprot/A0A803SZJ4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:aldh1l2 ^@ http://purl.uniprot.org/uniprot/G1KRQ0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.|||In the N-terminal section; belongs to the GART family. http://togogenome.org/gene/28377:LOC100553910 ^@ http://purl.uniprot.org/uniprot/A0A803T295 ^@ Similarity ^@ Belongs to the GST superfamily. Mu family. http://togogenome.org/gene/28377:acss3 ^@ http://purl.uniprot.org/uniprot/G1KPY7 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/28377:nav2 ^@ http://purl.uniprot.org/uniprot/A0A803TZD4 ^@ Similarity ^@ Belongs to the Nav/unc-53 family. http://togogenome.org/gene/28377:mmp20 ^@ http://purl.uniprot.org/uniprot/G1KUQ8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/28377:srpx ^@ http://purl.uniprot.org/uniprot/G1KQ90 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:foxp3 ^@ http://purl.uniprot.org/uniprot/G1KNU3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:spty2d1 ^@ http://purl.uniprot.org/uniprot/G1K891 ^@ Similarity ^@ Belongs to the SPT2 family. http://togogenome.org/gene/28377:oat ^@ http://purl.uniprot.org/uniprot/G1KU46 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/28377:slc25a22 ^@ http://purl.uniprot.org/uniprot/R4GBV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/28377:LOC100552501 ^@ http://purl.uniprot.org/uniprot/A0A803STP1 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/28377:ccdc43 ^@ http://purl.uniprot.org/uniprot/G1KMG5 ^@ Similarity ^@ Belongs to the CCDC43 family. http://togogenome.org/gene/28377:cnksr3 ^@ http://purl.uniprot.org/uniprot/G1KE49 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/28377:ruvbl1 ^@ http://purl.uniprot.org/uniprot/G1KGA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. http://togogenome.org/gene/28377:ccr7 ^@ http://purl.uniprot.org/uniprot/A0A803SVQ2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:nol8 ^@ http://purl.uniprot.org/uniprot/A0A803T5G0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/28377:irf6 ^@ http://purl.uniprot.org/uniprot/G1KEV4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:slc41a3 ^@ http://purl.uniprot.org/uniprot/A0A803SSQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/28377:ptp4a3 ^@ http://purl.uniprot.org/uniprot/G1K8Q4 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/28377:homer1 ^@ http://purl.uniprot.org/uniprot/A0A803T0N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/28377:pyy ^@ http://purl.uniprot.org/uniprot/G1KDC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/28377:sbf2 ^@ http://purl.uniprot.org/uniprot/A0A803TNQ2 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/28377:rnmt ^@ http://purl.uniprot.org/uniprot/R4GB35 ^@ Similarity ^@ In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family. http://togogenome.org/gene/28377:golt1a ^@ http://purl.uniprot.org/uniprot/R4GBL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/28377:LOC100567438 ^@ http://purl.uniprot.org/uniprot/G1KDQ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:ppp1r14a ^@ http://purl.uniprot.org/uniprot/H9G8B8 ^@ Similarity ^@ Belongs to the PP1 inhibitor family. http://togogenome.org/gene/28377:zdhhc22 ^@ http://purl.uniprot.org/uniprot/R4GBC6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/28377:agt ^@ http://purl.uniprot.org/uniprot/G1K9T6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family.|||Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.|||Secreted|||Stimulates aldosterone release. http://togogenome.org/gene/28377:LOC100553581 ^@ http://purl.uniprot.org/uniprot/H9G8Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNF-like-inhibitor family.|||Secreted http://togogenome.org/gene/28377:myd88 ^@ http://purl.uniprot.org/uniprot/R4GCS1 ^@ Function|||Subcellular Location Annotation ^@ Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.|||Cytoplasm http://togogenome.org/gene/28377:adcy2 ^@ http://purl.uniprot.org/uniprot/G1KJT7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/28377:timeless ^@ http://purl.uniprot.org/uniprot/G1KSP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the timeless family.|||Nucleus http://togogenome.org/gene/28377:LOC100556126 ^@ http://purl.uniprot.org/uniprot/G1KD14 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.|||Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.|||Membrane|||This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. http://togogenome.org/gene/28377:elovl5 ^@ http://purl.uniprot.org/uniprot/G1KHX1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL5 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||dendrite http://togogenome.org/gene/28377:LOC100556963 ^@ http://purl.uniprot.org/uniprot/G1KCZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:hps5 ^@ http://purl.uniprot.org/uniprot/A0A803SKL3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HPS5 family.|||Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.|||May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.|||cytosol http://togogenome.org/gene/28377:nos1 ^@ http://purl.uniprot.org/uniprot/H9GND1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOS family.|||dendritic spine|||sarcolemma http://togogenome.org/gene/28377:vps41 ^@ http://purl.uniprot.org/uniprot/A0A803TP13|||http://purl.uniprot.org/uniprot/G1KU87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS41 family.|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.|||Vesicle|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/28377:st8sia5 ^@ http://purl.uniprot.org/uniprot/A0A803T542|||http://purl.uniprot.org/uniprot/A5I881|||http://purl.uniprot.org/uniprot/G1KME3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/28377:rbp2 ^@ http://purl.uniprot.org/uniprot/G1KBY5 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/28377:ckmt2 ^@ http://purl.uniprot.org/uniprot/G1KKN7 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/28377:psmg1 ^@ http://purl.uniprot.org/uniprot/G1K897 ^@ Similarity ^@ Belongs to the PSMG1 family. http://togogenome.org/gene/28377:sfxn1 ^@ http://purl.uniprot.org/uniprot/G1KQJ2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/28377:mlnr ^@ http://purl.uniprot.org/uniprot/G1K9N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:ndfip1 ^@ http://purl.uniprot.org/uniprot/G1KNQ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:bco1 ^@ http://purl.uniprot.org/uniprot/H9GES3 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/28377:fam3c ^@ http://purl.uniprot.org/uniprot/A0A803TT60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/28377:cfap36 ^@ http://purl.uniprot.org/uniprot/G1KC16 ^@ Similarity ^@ Belongs to the CFAP36 family. http://togogenome.org/gene/28377:cops8 ^@ http://purl.uniprot.org/uniprot/G1KK67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN8 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:ppargc1b ^@ http://purl.uniprot.org/uniprot/G1KRI7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:ermp1 ^@ http://purl.uniprot.org/uniprot/G1KCI4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:ncoa2 ^@ http://purl.uniprot.org/uniprot/G1KQR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/28377:dlst ^@ http://purl.uniprot.org/uniprot/G1KT20 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/28377:btd ^@ http://purl.uniprot.org/uniprot/G1KAS1 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/28377:frg1 ^@ http://purl.uniprot.org/uniprot/G1KFW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRG1 family.|||Cajal body|||nucleolus http://togogenome.org/gene/28377:pfn3 ^@ http://purl.uniprot.org/uniprot/G1KA02 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/28377:itprip ^@ http://purl.uniprot.org/uniprot/G1KDR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Membrane http://togogenome.org/gene/28377:vprbp ^@ http://purl.uniprot.org/uniprot/G1KGY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPRBP/DCAF1 family.|||Nucleus http://togogenome.org/gene/28377:ndrg3 ^@ http://purl.uniprot.org/uniprot/A0A803TVD0|||http://purl.uniprot.org/uniprot/G1KFN4 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/28377:otulin ^@ http://purl.uniprot.org/uniprot/G1K8E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/28377:apob ^@ http://purl.uniprot.org/uniprot/G1KKJ8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:cept1 ^@ http://purl.uniprot.org/uniprot/A0A803SVS8|||http://purl.uniprot.org/uniprot/G1KCZ8 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/28377:slc35a1 ^@ http://purl.uniprot.org/uniprot/G1KQN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:arsb ^@ http://purl.uniprot.org/uniprot/G1KT81 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/28377:fam161b ^@ http://purl.uniprot.org/uniprot/A0A803SU21 ^@ Similarity ^@ Belongs to the FAM161 family. http://togogenome.org/gene/28377:agk ^@ http://purl.uniprot.org/uniprot/G1KL63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AGK family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/28377:hcrt ^@ http://purl.uniprot.org/uniprot/G1KUK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the orexin family.|||Endoplasmic reticulum|||Rough endoplasmic reticulum|||Synapse|||Vesicle http://togogenome.org/gene/28377:fam65b ^@ http://purl.uniprot.org/uniprot/A0A803TJL3 ^@ Similarity ^@ Belongs to the RIPOR family. http://togogenome.org/gene/28377:entpd3 ^@ http://purl.uniprot.org/uniprot/A0A803THC8|||http://purl.uniprot.org/uniprot/G1KBF4 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/28377:LOC100552454 ^@ http://purl.uniprot.org/uniprot/G1KYQ0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/28377:lias ^@ http://purl.uniprot.org/uniprot/G1KGD8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Mitochondrion http://togogenome.org/gene/28377:tmprss2 ^@ http://purl.uniprot.org/uniprot/G1KE28 ^@ Caution|||Similarity ^@ Belongs to the peptidase S1 family. Snake venom subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:fgd6 ^@ http://purl.uniprot.org/uniprot/G1KN38 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/28377:sec22a ^@ http://purl.uniprot.org/uniprot/G1KKS3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/28377:LOC100552581 ^@ http://purl.uniprot.org/uniprot/G1KEP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/28377:itgb1 ^@ http://purl.uniprot.org/uniprot/A0A803T2U2|||http://purl.uniprot.org/uniprot/G1KFZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:serping1 ^@ http://purl.uniprot.org/uniprot/G1KG82 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/28377:akirin2 ^@ http://purl.uniprot.org/uniprot/G1KQC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/28377:psmc3 ^@ http://purl.uniprot.org/uniprot/G1KAN8 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/28377:spryd4 ^@ http://purl.uniprot.org/uniprot/G1KYE7 ^@ Function|||Similarity ^@ Belongs to the ohanin/vespryn family.|||Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal. http://togogenome.org/gene/28377:nodal ^@ http://purl.uniprot.org/uniprot/G1KHQ1 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/28377:LOC100554428 ^@ http://purl.uniprot.org/uniprot/G1KH64 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/28377:glo1 ^@ http://purl.uniprot.org/uniprot/A0A803TV79 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the glyoxalase I family.|||Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.|||Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. http://togogenome.org/gene/28377:jph1 ^@ http://purl.uniprot.org/uniprot/G1KN76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/28377:LOC100554815 ^@ http://purl.uniprot.org/uniprot/G1KTZ8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:alg11 ^@ http://purl.uniprot.org/uniprot/G1KT53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.|||Endoplasmic reticulum membrane|||Required for N-linked oligosaccharide assembly. http://togogenome.org/gene/28377:kynu ^@ http://purl.uniprot.org/uniprot/A0A803TNS6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:ano7 ^@ http://purl.uniprot.org/uniprot/G1K9Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:mdfic ^@ http://purl.uniprot.org/uniprot/G1KFM4 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/28377:sar1a ^@ http://purl.uniprot.org/uniprot/G1K9I8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/28377:LOC100554027 ^@ http://purl.uniprot.org/uniprot/G1K8I4 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/28377:rpl10a ^@ http://purl.uniprot.org/uniprot/G1KIW5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/28377:tbx20 ^@ http://purl.uniprot.org/uniprot/G1KGN2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/28377:nfib ^@ http://purl.uniprot.org/uniprot/A0A803T720|||http://purl.uniprot.org/uniprot/G1KUE4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/28377:ifrd2 ^@ http://purl.uniprot.org/uniprot/G1KI72 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/28377:tnpo1 ^@ http://purl.uniprot.org/uniprot/G1KJ76 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/28377:mrgbp ^@ http://purl.uniprot.org/uniprot/R4GAN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EAF7 family.|||Nucleus http://togogenome.org/gene/28377:oprm1 ^@ http://purl.uniprot.org/uniprot/G1KE66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Endosome|||Membrane|||Perikaryon|||axon|||dendrite http://togogenome.org/gene/28377:lhpp ^@ http://purl.uniprot.org/uniprot/A0A803T2P1|||http://purl.uniprot.org/uniprot/G1KU51 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/28377:lamp3 ^@ http://purl.uniprot.org/uniprot/G1KGN9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/28377:LOC100566014 ^@ http://purl.uniprot.org/uniprot/G1KBQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/28377:gap43 ^@ http://purl.uniprot.org/uniprot/G1KQH4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neuromodulin family.|||Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.|||Cell membrane|||Membrane|||Palmitoylated. Palmitoylation is essential for plasma membrane association.|||Synapse|||This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.|||filopodium membrane|||growth cone membrane http://togogenome.org/gene/28377:snx3 ^@ http://purl.uniprot.org/uniprot/G1KEW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome|||Endosome|||phagosome http://togogenome.org/gene/28377:cntnap1 ^@ http://purl.uniprot.org/uniprot/G1KPM3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||paranodal septate junction http://togogenome.org/gene/28377:rab32 ^@ http://purl.uniprot.org/uniprot/A0A803U153 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/28377:rundc3b ^@ http://purl.uniprot.org/uniprot/G1KS79 ^@ Similarity ^@ Belongs to the RUNDC3 family. http://togogenome.org/gene/28377:kdm1b ^@ http://purl.uniprot.org/uniprot/G1KBR2 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. FIG1 subfamily. http://togogenome.org/gene/28377:atic ^@ http://purl.uniprot.org/uniprot/G1KRC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PurH family.|||cytosol http://togogenome.org/gene/28377:LOC100564169 ^@ http://purl.uniprot.org/uniprot/G1KHX4 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/28377:utp15 ^@ http://purl.uniprot.org/uniprot/G1KIV1 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/28377:pkia ^@ http://purl.uniprot.org/uniprot/G1KNM1 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/28377:asic4 ^@ http://purl.uniprot.org/uniprot/A0A803TFB2|||http://purl.uniprot.org/uniprot/G1KPL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/28377:kcna4 ^@ http://purl.uniprot.org/uniprot/G1KA04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.|||Cell membrane|||Membrane|||axon http://togogenome.org/gene/28377:map2k6 ^@ http://purl.uniprot.org/uniprot/R4GDI3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/28377:LOC103278034 ^@ http://purl.uniprot.org/uniprot/G1KLF5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/28377:dip2c ^@ http://purl.uniprot.org/uniprot/A0A803SM24|||http://purl.uniprot.org/uniprot/A0A803TDP6 ^@ Similarity ^@ Belongs to the DIP2 family. http://togogenome.org/gene/28377:hoxb5 ^@ http://purl.uniprot.org/uniprot/A0A803TV01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/28377:LOC100555467 ^@ http://purl.uniprot.org/uniprot/G1KNA5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:LOC100565895 ^@ http://purl.uniprot.org/uniprot/R4G9F0 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/28377:neu4 ^@ http://purl.uniprot.org/uniprot/G1K8I1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/28377:foxp2 ^@ http://purl.uniprot.org/uniprot/G1KFZ6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:ppa1 ^@ http://purl.uniprot.org/uniprot/A0A803TF59 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/28377:pmm1 ^@ http://purl.uniprot.org/uniprot/G1KD11 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/28377:LOC100565422 ^@ http://purl.uniprot.org/uniprot/G1KG34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/28377:ptger1 ^@ http://purl.uniprot.org/uniprot/G1KTE4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/28377:plpp3 ^@ http://purl.uniprot.org/uniprot/G1K8D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/28377:gpr179 ^@ http://purl.uniprot.org/uniprot/A0A803SMV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/28377:rfc5 ^@ http://purl.uniprot.org/uniprot/H9GNG0 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/28377:ube2n ^@ http://purl.uniprot.org/uniprot/G1KMH7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/28377:arhgap26 ^@ http://purl.uniprot.org/uniprot/A0A803T7T0|||http://purl.uniprot.org/uniprot/A0A803TYN2 ^@ Subcellular Location Annotation ^@ cytoskeleton|||focal adhesion http://togogenome.org/gene/28377:LOC100551746 ^@ http://purl.uniprot.org/uniprot/R4G936 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNF-like-inhibitor family.|||Secreted http://togogenome.org/gene/28377:r3hdml ^@ http://purl.uniprot.org/uniprot/G1KT36 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/28377:ankrd13d ^@ http://purl.uniprot.org/uniprot/G1KH90 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/28377:oprl1 ^@ http://purl.uniprot.org/uniprot/A0A803SYE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle|||G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.|||Membrane|||Vesicle http://togogenome.org/gene/28377:LOC100567007 ^@ http://purl.uniprot.org/uniprot/H9GFI1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/28377:LOC100565219 ^@ http://purl.uniprot.org/uniprot/A0A803SY69 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GST superfamily. Pi family.|||Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.|||Cytoplasm|||Homodimer.|||Mitochondrion|||Nucleus http://togogenome.org/gene/28377:cwc15 ^@ http://purl.uniprot.org/uniprot/G1KPD7 ^@ Similarity ^@ Belongs to the CWC15 family. http://togogenome.org/gene/28377:rpl7l1 ^@ http://purl.uniprot.org/uniprot/A0A803TL42 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/28377:csf1r ^@ http://purl.uniprot.org/uniprot/G1KRD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:rps3a ^@ http://purl.uniprot.org/uniprot/G1KBE1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).|||Cytoplasm|||nucleolus http://togogenome.org/gene/28377:megf10 ^@ http://purl.uniprot.org/uniprot/A0A803SQJ0|||http://purl.uniprot.org/uniprot/G1KB28 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:fam212a ^@ http://purl.uniprot.org/uniprot/A0A803TZ60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INKA family.|||Nucleus http://togogenome.org/gene/28377:LOC100561542 ^@ http://purl.uniprot.org/uniprot/G1KNN1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/28377:vps35 ^@ http://purl.uniprot.org/uniprot/H9GJW8 ^@ Function|||Similarity ^@ Belongs to the VPS35 family.|||Plays a role in vesicular protein sorting. http://togogenome.org/gene/28377:cdr2l ^@ http://purl.uniprot.org/uniprot/G1KEX7 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/28377:LOC100556689 ^@ http://purl.uniprot.org/uniprot/G1KRB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:dpf1 ^@ http://purl.uniprot.org/uniprot/H9GJW0 ^@ Similarity ^@ Belongs to the requiem/DPF family. http://togogenome.org/gene/28377:prkg2 ^@ http://purl.uniprot.org/uniprot/G1KJX1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. http://togogenome.org/gene/28377:timp4 ^@ http://purl.uniprot.org/uniprot/G1KNU7 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/28377:azin1 ^@ http://purl.uniprot.org/uniprot/G1KIN5 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/28377:met ^@ http://purl.uniprot.org/uniprot/G1KI46 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:timp2 ^@ http://purl.uniprot.org/uniprot/A0A803SMV3 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/28377:LOC100555389 ^@ http://purl.uniprot.org/uniprot/G1KNB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/28377:LOC100561212 ^@ http://purl.uniprot.org/uniprot/A0A803T7U3|||http://purl.uniprot.org/uniprot/A0A803TUG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/28377:coq10a ^@ http://purl.uniprot.org/uniprot/G1KGQ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/28377:timm17a ^@ http://purl.uniprot.org/uniprot/G1KDF2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/28377:qpct ^@ http://purl.uniprot.org/uniprot/G1K927 ^@ Function|||Similarity ^@ Belongs to the glutaminyl-peptide cyclotransferase family.|||Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. http://togogenome.org/gene/28377:LOC100566088 ^@ http://purl.uniprot.org/uniprot/G1KGX8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:mecp2 ^@ http://purl.uniprot.org/uniprot/G1KME7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:ppp1r12a ^@ http://purl.uniprot.org/uniprot/A0A803SXD0|||http://purl.uniprot.org/uniprot/A0A803THU1|||http://purl.uniprot.org/uniprot/A0A803TVQ8|||http://purl.uniprot.org/uniprot/G1KPJ2 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits. http://togogenome.org/gene/28377:ecsit ^@ http://purl.uniprot.org/uniprot/G1KTD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ECSIT family.|||Cytoplasm|||Mitochondrion|||Nucleus http://togogenome.org/gene/28377:lin52 ^@ http://purl.uniprot.org/uniprot/A0A803SQT3|||http://purl.uniprot.org/uniprot/G1KSG5 ^@ Similarity ^@ Belongs to the lin-52 family. http://togogenome.org/gene/28377:atp5c1 ^@ http://purl.uniprot.org/uniprot/A0A803T1I5|||http://purl.uniprot.org/uniprot/G1KCP0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/28377:gprin3 ^@ http://purl.uniprot.org/uniprot/G1KWM0 ^@ Function ^@ May be involved in neurite outgrowth. http://togogenome.org/gene/28377:apom ^@ http://purl.uniprot.org/uniprot/A0A803U0U4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family. Highly divergent.|||Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.|||Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.|||Secreted http://togogenome.org/gene/28377:slc7a11 ^@ http://purl.uniprot.org/uniprot/G1KA07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:chrna4 ^@ http://purl.uniprot.org/uniprot/G1KER0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/28377:dock7 ^@ http://purl.uniprot.org/uniprot/A0A803SLW6|||http://purl.uniprot.org/uniprot/G1KHC5 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/28377:ddc ^@ http://purl.uniprot.org/uniprot/G1KHR5 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/28377:LOC100553233 ^@ http://purl.uniprot.org/uniprot/G1KJJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:ltbp2 ^@ http://purl.uniprot.org/uniprot/A0A803TKY9|||http://purl.uniprot.org/uniprot/G1KSS0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/28377:arl8b ^@ http://purl.uniprot.org/uniprot/A0A803TSE8 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/28377:sfr1 ^@ http://purl.uniprot.org/uniprot/A0A803U1H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SFR1/MEI5 family.|||Nucleus http://togogenome.org/gene/28377:c1h11orf49 ^@ http://purl.uniprot.org/uniprot/G1KBR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSTPP1 family.|||cytoskeleton http://togogenome.org/gene/28377:LOC100561503 ^@ http://purl.uniprot.org/uniprot/A0A803TH23 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Homodimer. Heterodimer; with a rar molecule.|||Nucleus|||Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. http://togogenome.org/gene/28377:pld1 ^@ http://purl.uniprot.org/uniprot/G1KSE7 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/28377:LOC100566109 ^@ http://purl.uniprot.org/uniprot/A0A803TC62|||http://purl.uniprot.org/uniprot/A0A803TSF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/28377:cnpy1 ^@ http://purl.uniprot.org/uniprot/A0A803T698|||http://purl.uniprot.org/uniprot/A0A803TSP0 ^@ Similarity ^@ Belongs to the canopy family. http://togogenome.org/gene/28377:pkn1 ^@ http://purl.uniprot.org/uniprot/G1KTB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Nucleus http://togogenome.org/gene/28377:spag9 ^@ http://purl.uniprot.org/uniprot/G1KAB2|||http://purl.uniprot.org/uniprot/R4GBD4 ^@ Similarity ^@ Belongs to the JIP scaffold family. http://togogenome.org/gene/28377:syndig1 ^@ http://purl.uniprot.org/uniprot/G1K9I1 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/28377:LOC100565889 ^@ http://purl.uniprot.org/uniprot/R4GD57 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/28377:hsf2 ^@ http://purl.uniprot.org/uniprot/G1K9B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/28377:sfrp2 ^@ http://purl.uniprot.org/uniprot/G1KRK6 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:LOC100551729 ^@ http://purl.uniprot.org/uniprot/G1KQD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:ucn3 ^@ http://purl.uniprot.org/uniprot/G1KB15 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Binds with high affinity to CRF receptors 2-alpha and 2-beta.|||Secreted|||Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. http://togogenome.org/gene/28377:eaf2 ^@ http://purl.uniprot.org/uniprot/G1KD80 ^@ Similarity ^@ Belongs to the EAF family. http://togogenome.org/gene/28377:grik4 ^@ http://purl.uniprot.org/uniprot/H9G757 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/28377:ywhab ^@ http://purl.uniprot.org/uniprot/G1KLJ0 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/28377:LOC100555069 ^@ http://purl.uniprot.org/uniprot/G1KMB2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/28377:dmrt3 ^@ http://purl.uniprot.org/uniprot/G1KAM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/28377:LOC100553824 ^@ http://purl.uniprot.org/uniprot/A0A803TB36 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/28377:tmem19 ^@ http://purl.uniprot.org/uniprot/G1KGJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/28377:ate1 ^@ http://purl.uniprot.org/uniprot/A0A803TB07|||http://purl.uniprot.org/uniprot/A0A803TJ95|||http://purl.uniprot.org/uniprot/A0A803TPU5 ^@ Function|||Similarity ^@ Belongs to the R-transferase family.|||Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. http://togogenome.org/gene/28377:dcaf13 ^@ http://purl.uniprot.org/uniprot/G1KIY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DCAF13/WDSOF1 family.|||nucleolus http://togogenome.org/gene/28377:gja8 ^@ http://purl.uniprot.org/uniprot/G1KPB7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/28377:LOC100562486 ^@ http://purl.uniprot.org/uniprot/G1KXR0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/28377:bet1 ^@ http://purl.uniprot.org/uniprot/G1KNI2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:ddx4 ^@ http://purl.uniprot.org/uniprot/G1KQJ8 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/28377:axl ^@ http://purl.uniprot.org/uniprot/H9G8C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Membrane http://togogenome.org/gene/28377:flt4 ^@ http://purl.uniprot.org/uniprot/G1KRW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:mmp13 ^@ http://purl.uniprot.org/uniprot/G1KMI9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/28377:myoz3 ^@ http://purl.uniprot.org/uniprot/A0A803SXW7 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/28377:dhx8 ^@ http://purl.uniprot.org/uniprot/G1KP21 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:LOC100559434 ^@ http://purl.uniprot.org/uniprot/G1KW27 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/28377:myf6 ^@ http://purl.uniprot.org/uniprot/A0A803TTJ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:LOC100567856 ^@ http://purl.uniprot.org/uniprot/G1K953 ^@ Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 56 family.|||Monomer. http://togogenome.org/gene/28377:psen1 ^@ http://purl.uniprot.org/uniprot/A0A803SNS1|||http://purl.uniprot.org/uniprot/G1KSC0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Cytoplasmic granule|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||Synapse|||The PAL motif is required for normal active site conformation.|||axon|||neuron projection http://togogenome.org/gene/28377:cdk7 ^@ http://purl.uniprot.org/uniprot/G1KSN0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/28377:ctnnd1 ^@ http://purl.uniprot.org/uniprot/A0A803TFZ4|||http://purl.uniprot.org/uniprot/G1KG06 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/28377:slc25a18 ^@ http://purl.uniprot.org/uniprot/G1KM82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/28377:parvb ^@ http://purl.uniprot.org/uniprot/A0A803SNJ9|||http://purl.uniprot.org/uniprot/G1KXP5 ^@ Similarity ^@ Belongs to the parvin family. http://togogenome.org/gene/28377:LOC100562425 ^@ http://purl.uniprot.org/uniprot/G1KM52 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/28377:gstz1 ^@ http://purl.uniprot.org/uniprot/G1KTM3 ^@ Similarity ^@ Belongs to the GST superfamily. Zeta family. http://togogenome.org/gene/28377:murc ^@ http://purl.uniprot.org/uniprot/A0A803T1S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/28377:fabp2 ^@ http://purl.uniprot.org/uniprot/G1KNM3 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/28377:nprl2 ^@ http://purl.uniprot.org/uniprot/G1KFZ4 ^@ Similarity ^@ Belongs to the NPR2 family. http://togogenome.org/gene/28377:zfx ^@ http://purl.uniprot.org/uniprot/G1KGC2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:ldlrad3 ^@ http://purl.uniprot.org/uniprot/G1KDP6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:psmb3 ^@ http://purl.uniprot.org/uniprot/G1KNE8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:clcf1 ^@ http://purl.uniprot.org/uniprot/A0A803T531 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/28377:soga1 ^@ http://purl.uniprot.org/uniprot/A0A803TZX2 ^@ Similarity ^@ Belongs to the SOGA family. http://togogenome.org/gene/28377:hmox1 ^@ http://purl.uniprot.org/uniprot/G1KSW4 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/28377:hspa4l ^@ http://purl.uniprot.org/uniprot/G1KLL7 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/28377:msh6 ^@ http://purl.uniprot.org/uniprot/G1KPH8 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR). http://togogenome.org/gene/28377:sec22c ^@ http://purl.uniprot.org/uniprot/G1KFL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/28377:b3gnt9 ^@ http://purl.uniprot.org/uniprot/G1KN94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:elf2 ^@ http://purl.uniprot.org/uniprot/A0A803T572|||http://purl.uniprot.org/uniprot/G1KA65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/28377:gpat3 ^@ http://purl.uniprot.org/uniprot/A0A803U0B7 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/28377:nkx2-5 ^@ http://purl.uniprot.org/uniprot/G1KQP9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:mterf2 ^@ http://purl.uniprot.org/uniprot/G1KQX1 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/28377:tspan8 ^@ http://purl.uniprot.org/uniprot/G1KG83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/28377:tmem168 ^@ http://purl.uniprot.org/uniprot/G1KG11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM168 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/28377:bcap29 ^@ http://purl.uniprot.org/uniprot/G1KQS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.|||Membrane http://togogenome.org/gene/28377:rpa3 ^@ http://purl.uniprot.org/uniprot/G1KN66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 3 family.|||Nucleus http://togogenome.org/gene/28377:LOC100552777 ^@ http://purl.uniprot.org/uniprot/A0A803TT71 ^@ Similarity ^@ Belongs to the IUNH family. http://togogenome.org/gene/28377:ugp2 ^@ http://purl.uniprot.org/uniprot/G1KEX2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/28377:LOC100556586 ^@ http://purl.uniprot.org/uniprot/G1KTJ5 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/28377:LOC100557105 ^@ http://purl.uniprot.org/uniprot/A0A803T006 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/28377:gpr137b ^@ http://purl.uniprot.org/uniprot/G1KAK8 ^@ Subcellular Location Annotation ^@ Lysosome membrane|||Membrane http://togogenome.org/gene/28377:habp4 ^@ http://purl.uniprot.org/uniprot/G1KMY4 ^@ Similarity ^@ Belongs to the SERBP1-HABP4 family. http://togogenome.org/gene/28377:msrb3 ^@ http://purl.uniprot.org/uniprot/A0A803THG1|||http://purl.uniprot.org/uniprot/A0A803TYD3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/28377:dnmt3l ^@ http://purl.uniprot.org/uniprot/A0A803TK47|||http://purl.uniprot.org/uniprot/R4GDL3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:dlx5 ^@ http://purl.uniprot.org/uniprot/G1KQ78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/28377:fshr ^@ http://purl.uniprot.org/uniprot/G1KSH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.|||Membrane http://togogenome.org/gene/28377:LOC100558465 ^@ http://purl.uniprot.org/uniprot/L7MZI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/28377:mapk8ip1 ^@ http://purl.uniprot.org/uniprot/G1KQB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JIP scaffold family.|||Cytoplasm http://togogenome.org/gene/28377:ptprf ^@ http://purl.uniprot.org/uniprot/A0A803T423|||http://purl.uniprot.org/uniprot/A0A803TC59|||http://purl.uniprot.org/uniprot/A0A803TIC2|||http://purl.uniprot.org/uniprot/A0A803TLP7|||http://purl.uniprot.org/uniprot/G1KPK7 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. http://togogenome.org/gene/28377:cenpq ^@ http://purl.uniprot.org/uniprot/R4GB65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-Q/OKP1 family.|||Nucleus http://togogenome.org/gene/28377:gars ^@ http://purl.uniprot.org/uniprot/G1KEH7 ^@ Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Homodimer. http://togogenome.org/gene/28377:tfcp2 ^@ http://purl.uniprot.org/uniprot/G1KM92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/28377:btf3 ^@ http://purl.uniprot.org/uniprot/A0A803TIH9 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/28377:slc30a1 ^@ http://purl.uniprot.org/uniprot/G1KSH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/28377:plppr2 ^@ http://purl.uniprot.org/uniprot/A0A803SMM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/28377:pds5a ^@ http://purl.uniprot.org/uniprot/A0A803TT61 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:foxa1 ^@ http://purl.uniprot.org/uniprot/A0A803TSG9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:fam53c ^@ http://purl.uniprot.org/uniprot/G1KG13 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/28377:LOC100559122 ^@ http://purl.uniprot.org/uniprot/A0A803U0A4|||http://purl.uniprot.org/uniprot/G1KUV2 ^@ Function|||Similarity ^@ Belongs to the ohanin/vespryn family.|||Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal. http://togogenome.org/gene/28377:smpx ^@ http://purl.uniprot.org/uniprot/G1KSZ9 ^@ Function|||Similarity ^@ Belongs to the SMPX family.|||Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. http://togogenome.org/gene/28377:adgrg2 ^@ http://purl.uniprot.org/uniprot/G1KLX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/28377:LOC100555907 ^@ http://purl.uniprot.org/uniprot/G1KRD1 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/28377:fut4 ^@ http://purl.uniprot.org/uniprot/G1KPG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/28377:sept3 ^@ http://purl.uniprot.org/uniprot/A0A803THZ0|||http://purl.uniprot.org/uniprot/G1KCI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cytoplasm http://togogenome.org/gene/28377:ndufb1 ^@ http://purl.uniprot.org/uniprot/G1KX62 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/28377:txlng ^@ http://purl.uniprot.org/uniprot/G1KL89 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/28377:ambn ^@ http://purl.uniprot.org/uniprot/A0A0K2GMW1|||http://purl.uniprot.org/uniprot/A0A803TIS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ameloblastin family.|||Involved in the mineralization and structural organization of enamel.|||extracellular matrix http://togogenome.org/gene/28377:p2ry1 ^@ http://purl.uniprot.org/uniprot/G1KL06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:adam11 ^@ http://purl.uniprot.org/uniprot/A0A803TD60|||http://purl.uniprot.org/uniprot/G1KMP1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:lbh ^@ http://purl.uniprot.org/uniprot/A0A803TZ49 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LBH family.|||Cytoplasm|||Nucleus|||Transcriptional activator. http://togogenome.org/gene/28377:LOC100558405 ^@ http://purl.uniprot.org/uniprot/G1KNK4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:LOC100567925 ^@ http://purl.uniprot.org/uniprot/A0A803TSD2 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. http://togogenome.org/gene/28377:extl2 ^@ http://purl.uniprot.org/uniprot/G1KBJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/28377:eme1 ^@ http://purl.uniprot.org/uniprot/G1KDU1 ^@ Similarity ^@ Belongs to the EME1/MMS4 family. http://togogenome.org/gene/28377:ergic2 ^@ http://purl.uniprot.org/uniprot/G1KHL3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/28377:tp53rk ^@ http://purl.uniprot.org/uniprot/G1KSY3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. BUD32 family. http://togogenome.org/gene/28377:efhc2 ^@ http://purl.uniprot.org/uniprot/G1KUH5 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/28377:slc6a11 ^@ http://purl.uniprot.org/uniprot/G1KJK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/28377:b3galnt2 ^@ http://purl.uniprot.org/uniprot/G1K9Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:prdm1 ^@ http://purl.uniprot.org/uniprot/G1KE67 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.|||Nucleus|||Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. http://togogenome.org/gene/28377:ell2 ^@ http://purl.uniprot.org/uniprot/G1KMZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Nucleus http://togogenome.org/gene/28377:cldn14 ^@ http://purl.uniprot.org/uniprot/G1KMQ5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/28377:LOC100563070 ^@ http://purl.uniprot.org/uniprot/G1KGE3 ^@ Function|||Similarity ^@ Belongs to the ohanin/vespryn family.|||Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal. http://togogenome.org/gene/28377:acad9 ^@ http://purl.uniprot.org/uniprot/G1KN90 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/28377:pik3c2b ^@ http://purl.uniprot.org/uniprot/G1KGS9 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/28377:LOC100551943 ^@ http://purl.uniprot.org/uniprot/A0A803TIY7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/28377:amt ^@ http://purl.uniprot.org/uniprot/G1KGM6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvT family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/28377:sptbn1 ^@ http://purl.uniprot.org/uniprot/A0A803TN83|||http://purl.uniprot.org/uniprot/G1KM40 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/28377:ttc38 ^@ http://purl.uniprot.org/uniprot/G1KD52 ^@ Similarity ^@ Belongs to the TTC38 family. http://togogenome.org/gene/28377:LOC100561746 ^@ http://purl.uniprot.org/uniprot/A0A803SSG8 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/28377:etv5 ^@ http://purl.uniprot.org/uniprot/G1KHF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/28377:cdk4 ^@ http://purl.uniprot.org/uniprot/A0A803T5Z1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/28377:b4galt7 ^@ http://purl.uniprot.org/uniprot/G1KFJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/28377:anxa1 ^@ http://purl.uniprot.org/uniprot/G1KLU8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the annexin family.|||Cell membrane|||Cytoplasm|||Lateral cell membrane|||Membrane|||Nucleus|||The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.|||cilium http://togogenome.org/gene/28377:traf5 ^@ http://purl.uniprot.org/uniprot/G1KSI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/28377:mrps27 ^@ http://purl.uniprot.org/uniprot/G1KJD7 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/28377:smco4 ^@ http://purl.uniprot.org/uniprot/G1KQ16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMCO4 family.|||Membrane http://togogenome.org/gene/28377:ggt7 ^@ http://purl.uniprot.org/uniprot/G1KJ41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyltransferase family.|||Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.|||Membrane http://togogenome.org/gene/28377:csad ^@ http://purl.uniprot.org/uniprot/G1KG61 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/28377:sema3c ^@ http://purl.uniprot.org/uniprot/G1KRJ8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:sesn1 ^@ http://purl.uniprot.org/uniprot/G1KF20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/28377:LOC100566739 ^@ http://purl.uniprot.org/uniprot/G1KAY0 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/28377:obfc1 ^@ http://purl.uniprot.org/uniprot/G1KDE1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.|||Component of the CST complex.|||Nucleus|||telomere http://togogenome.org/gene/28377:pik3r3 ^@ http://purl.uniprot.org/uniprot/A0A803T5A6|||http://purl.uniprot.org/uniprot/G1KRT8 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/28377:tiparp ^@ http://purl.uniprot.org/uniprot/G1K9I0 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/28377:acsl1 ^@ http://purl.uniprot.org/uniprot/G1KB02 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. http://togogenome.org/gene/28377:egfl6 ^@ http://purl.uniprot.org/uniprot/G1K9P9 ^@ Caution|||Similarity ^@ Belongs to the nephronectin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:tlx3 ^@ http://purl.uniprot.org/uniprot/A0A803SX43|||http://purl.uniprot.org/uniprot/A0A803T5Y3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:hint1 ^@ http://purl.uniprot.org/uniprot/A0A803T6X4 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/28377:rev3l ^@ http://purl.uniprot.org/uniprot/G1KL83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||Nucleus http://togogenome.org/gene/28377:kcna7 ^@ http://purl.uniprot.org/uniprot/A0A803TTA0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:trappc3l ^@ http://purl.uniprot.org/uniprot/A0A803U079 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/28377:hyi ^@ http://purl.uniprot.org/uniprot/G1KNW7 ^@ Function|||Similarity ^@ Belongs to the hyi family.|||Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). http://togogenome.org/gene/28377:eif2a ^@ http://purl.uniprot.org/uniprot/G1KGY6 ^@ Function|||Similarity ^@ Belongs to the WD repeat EIF2A family.|||Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. http://togogenome.org/gene/28377:LOC100556634 ^@ http://purl.uniprot.org/uniprot/A0A803SZB0|||http://purl.uniprot.org/uniprot/G1KMP7 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/28377:nmd3 ^@ http://purl.uniprot.org/uniprot/G1KGH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.|||Belongs to the NMD3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:LOC100564639 ^@ http://purl.uniprot.org/uniprot/G1KFF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/28377:ywhaz ^@ http://purl.uniprot.org/uniprot/A0A803TEF5 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/28377:slc37a3 ^@ http://purl.uniprot.org/uniprot/G1KMT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/28377:ip6k1 ^@ http://purl.uniprot.org/uniprot/G1KGD5 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/28377:mcur1 ^@ http://purl.uniprot.org/uniprot/G1KC38 ^@ Similarity ^@ Belongs to the CCDC90 family. http://togogenome.org/gene/28377:nr3c1 ^@ http://purl.uniprot.org/uniprot/G1KP59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Mitochondrion|||Nucleus|||centrosome|||spindle http://togogenome.org/gene/28377:hnrnpk ^@ http://purl.uniprot.org/uniprot/G1K9R8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm http://togogenome.org/gene/28377:LOC100560224 ^@ http://purl.uniprot.org/uniprot/G1KC28 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/28377:myo1b ^@ http://purl.uniprot.org/uniprot/A0A803SKX1|||http://purl.uniprot.org/uniprot/A0A803T3K2|||http://purl.uniprot.org/uniprot/A0A803TJG8|||http://purl.uniprot.org/uniprot/A0A803TSF2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/28377:LOC100556626 ^@ http://purl.uniprot.org/uniprot/G1KHS3 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/28377:mfap5 ^@ http://purl.uniprot.org/uniprot/G1KTW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||extracellular matrix http://togogenome.org/gene/28377:enpp3 ^@ http://purl.uniprot.org/uniprot/G1K9M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||Secreted http://togogenome.org/gene/28377:psip1 ^@ http://purl.uniprot.org/uniprot/G1KUD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HDGF family.|||Nucleus http://togogenome.org/gene/28377:LOC107982405 ^@ http://purl.uniprot.org/uniprot/A0A803T5X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistin/FIZZ family.|||Secreted http://togogenome.org/gene/28377:kcng2 ^@ http://purl.uniprot.org/uniprot/G1K979 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:pld3 ^@ http://purl.uniprot.org/uniprot/H9G710 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/28377:tshb ^@ http://purl.uniprot.org/uniprot/A0A803ST38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/28377:LOC107982730 ^@ http://purl.uniprot.org/uniprot/R4G9I6 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/28377:LOC100561960 ^@ http://purl.uniprot.org/uniprot/G1K868 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WASH1 family.|||Early endosome membrane|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/28377:gngt2 ^@ http://purl.uniprot.org/uniprot/A0A803SZW1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/28377:romo1 ^@ http://purl.uniprot.org/uniprot/G1KFC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.|||Mitochondrion inner membrane http://togogenome.org/gene/28377:rnf114 ^@ http://purl.uniprot.org/uniprot/G1KRD0 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.|||Nucleus http://togogenome.org/gene/28377:LOC100555255 ^@ http://purl.uniprot.org/uniprot/G1KU55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiA prenyltransferase family.|||Converts protoheme IX and farnesyl diphosphate to heme O.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/28377:smad1 ^@ http://purl.uniprot.org/uniprot/G1KC06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:zufsp ^@ http://purl.uniprot.org/uniprot/A0A803TYT4 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C78 family. ZUFSP subfamily.|||Interacts with RPA1 and RPA2. http://togogenome.org/gene/28377:calcr ^@ http://purl.uniprot.org/uniprot/G1KNG6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Interacts with GPRASP2.|||Membrane http://togogenome.org/gene/28377:lrp5 ^@ http://purl.uniprot.org/uniprot/G1KQ71 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the LDLR family.|||Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.|||Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:chpf ^@ http://purl.uniprot.org/uniprot/G1KPM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/28377:acp5 ^@ http://purl.uniprot.org/uniprot/G1KTF9 ^@ Cofactor ^@ Binds 2 iron ions per subunit. http://togogenome.org/gene/28377:braf ^@ http://purl.uniprot.org/uniprot/A0A803ST73|||http://purl.uniprot.org/uniprot/A0A803TT54|||http://purl.uniprot.org/uniprot/G1KL20 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/28377:tmem14a ^@ http://purl.uniprot.org/uniprot/G1KIE3 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/28377:LOC103278887 ^@ http://purl.uniprot.org/uniprot/A0A803T3C6 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/28377:hoxc5 ^@ http://purl.uniprot.org/uniprot/G1KKN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/28377:irf1 ^@ http://purl.uniprot.org/uniprot/G1KMN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Nucleus http://togogenome.org/gene/28377:LOC100557431 ^@ http://purl.uniprot.org/uniprot/G1KRG0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/28377:meis2 ^@ http://purl.uniprot.org/uniprot/A0A803TGH3|||http://purl.uniprot.org/uniprot/A0A803TJP6|||http://purl.uniprot.org/uniprot/G1K8M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/28377:acyp2 ^@ http://purl.uniprot.org/uniprot/A0A803SL11 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/28377:dnttip2 ^@ http://purl.uniprot.org/uniprot/G1KYM4 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/28377:nxph1 ^@ http://purl.uniprot.org/uniprot/G1KNG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/28377:tsc22d2 ^@ http://purl.uniprot.org/uniprot/A0A803SUG0|||http://purl.uniprot.org/uniprot/G1KGW9 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/28377:sema3e ^@ http://purl.uniprot.org/uniprot/A0A803SM90 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:dll1 ^@ http://purl.uniprot.org/uniprot/G1KB45 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/28377:tbl1x ^@ http://purl.uniprot.org/uniprot/A0A803TNJ4|||http://purl.uniprot.org/uniprot/A0A803TQK0 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/28377:sybu ^@ http://purl.uniprot.org/uniprot/A0A803SXI6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:fam221a ^@ http://purl.uniprot.org/uniprot/G1KNU4 ^@ Similarity ^@ Belongs to the FAM221 family. http://togogenome.org/gene/28377:mtfr1 ^@ http://purl.uniprot.org/uniprot/G1KT28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/28377:LOC100553914 ^@ http://purl.uniprot.org/uniprot/G1KS40 ^@ Similarity|||Subunit ^@ Belongs to the ENDOU family.|||Monomer. http://togogenome.org/gene/28377:prdx6 ^@ http://purl.uniprot.org/uniprot/A0A803TBB8 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/28377:myo3a ^@ http://purl.uniprot.org/uniprot/G1KHV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||cytoskeleton http://togogenome.org/gene/28377:LOC100552862 ^@ http://purl.uniprot.org/uniprot/R4GAI6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:erbb4 ^@ http://purl.uniprot.org/uniprot/G1KJS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/28377:LOC100562073 ^@ http://purl.uniprot.org/uniprot/G1KDU9 ^@ Similarity ^@ Belongs to the PACS family. http://togogenome.org/gene/28377:lamp1 ^@ http://purl.uniprot.org/uniprot/G1K8E2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/28377:trh ^@ http://purl.uniprot.org/uniprot/A0A803TI60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRH family.|||Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.|||Secreted http://togogenome.org/gene/28377:stk4 ^@ http://purl.uniprot.org/uniprot/G1KLZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Nucleus http://togogenome.org/gene/28377:agtr1 ^@ http://purl.uniprot.org/uniprot/G1KFX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. http://togogenome.org/gene/28377:adam17 ^@ http://purl.uniprot.org/uniprot/G1K9M0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:pex5l ^@ http://purl.uniprot.org/uniprot/A0A803TBH4|||http://purl.uniprot.org/uniprot/A0A803TZM8 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/28377:LOC100560613 ^@ http://purl.uniprot.org/uniprot/G1KCM4 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/28377:add1 ^@ http://purl.uniprot.org/uniprot/A0A803TMD0|||http://purl.uniprot.org/uniprot/G1KDT9 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/28377:LOC103279179 ^@ http://purl.uniprot.org/uniprot/A0A803THP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the zona pellucida-binding protein Sp38 family.|||Secreted|||acrosome http://togogenome.org/gene/28377:hbp1 ^@ http://purl.uniprot.org/uniprot/G1KQL8 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. http://togogenome.org/gene/28377:frem1 ^@ http://purl.uniprot.org/uniprot/G1KUD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRAS1 family.|||Secreted http://togogenome.org/gene/28377:fam171a2 ^@ http://purl.uniprot.org/uniprot/G1KM06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM171 family.|||Membrane http://togogenome.org/gene/28377:ptcd2 ^@ http://purl.uniprot.org/uniprot/A0A803SN94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTCD2 family.|||Mitochondrion http://togogenome.org/gene/28377:fgfr2 ^@ http://purl.uniprot.org/uniprot/A0A803T6X6|||http://purl.uniprot.org/uniprot/G1KTN6|||http://purl.uniprot.org/uniprot/R4GC14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:fgf6 ^@ http://purl.uniprot.org/uniprot/A0A803SL30 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/28377:LOC100567693 ^@ http://purl.uniprot.org/uniprot/A0A803TE59|||http://purl.uniprot.org/uniprot/A0A803TQV8 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/28377:gcnt1 ^@ http://purl.uniprot.org/uniprot/G1KE93 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:htr4 ^@ http://purl.uniprot.org/uniprot/A0A803SS49|||http://purl.uniprot.org/uniprot/A0A803TJX6|||http://purl.uniprot.org/uniprot/G1KRL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Endosome|||Membrane|||This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. http://togogenome.org/gene/28377:il6st ^@ http://purl.uniprot.org/uniprot/G1KQG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/28377:clul1 ^@ http://purl.uniprot.org/uniprot/G1KHS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clusterin family.|||Secreted http://togogenome.org/gene/28377:amer3 ^@ http://purl.uniprot.org/uniprot/G1KD76 ^@ Similarity ^@ Belongs to the Amer family. http://togogenome.org/gene/28377:crhr2 ^@ http://purl.uniprot.org/uniprot/A0A803TPD2|||http://purl.uniprot.org/uniprot/G1KEL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Membrane http://togogenome.org/gene/28377:ogn ^@ http://purl.uniprot.org/uniprot/G1KIK2 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/28377:dhcr7 ^@ http://purl.uniprot.org/uniprot/A0A803TYD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/28377:khdrbs3 ^@ http://purl.uniprot.org/uniprot/G1KLV1 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/28377:ribc2 ^@ http://purl.uniprot.org/uniprot/G1KQ77 ^@ Similarity ^@ Belongs to the RIB43A family. http://togogenome.org/gene/28377:snx14 ^@ http://purl.uniprot.org/uniprot/G1KR43 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/28377:zhx1 ^@ http://purl.uniprot.org/uniprot/G1KJ36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/28377:ing1 ^@ http://purl.uniprot.org/uniprot/G1KF27 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/28377:ap1s3 ^@ http://purl.uniprot.org/uniprot/G1KCY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||clathrin-coated pit http://togogenome.org/gene/28377:phc3 ^@ http://purl.uniprot.org/uniprot/A0A803T6U1|||http://purl.uniprot.org/uniprot/A0A803U0Q0|||http://purl.uniprot.org/uniprot/G1KRQ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:cfap97 ^@ http://purl.uniprot.org/uniprot/G1KAJ3 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/28377:LOC100561817 ^@ http://purl.uniprot.org/uniprot/G1KSC9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|||Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:nox4 ^@ http://purl.uniprot.org/uniprot/A0A803T0F8|||http://purl.uniprot.org/uniprot/G1KQH3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:sema3b ^@ http://purl.uniprot.org/uniprot/G1KIX8 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:slc25a31 ^@ http://purl.uniprot.org/uniprot/G1KLN3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/28377:ghrhr ^@ http://purl.uniprot.org/uniprot/A0A803TI46|||http://purl.uniprot.org/uniprot/A0A803TRI7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:slc23a1 ^@ http://purl.uniprot.org/uniprot/G1KSI6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:zic1 ^@ http://purl.uniprot.org/uniprot/G1KFX6 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/28377:LOC100558940 ^@ http://purl.uniprot.org/uniprot/A0A803T5I6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/28377:prpsap1 ^@ http://purl.uniprot.org/uniprot/G1KHJ6 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/28377:prtfdc1 ^@ http://purl.uniprot.org/uniprot/A0A803SMR0|||http://purl.uniprot.org/uniprot/A0A803TKL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/28377:polr2d ^@ http://purl.uniprot.org/uniprot/G1KDT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/28377:LOC100553366 ^@ http://purl.uniprot.org/uniprot/R4GDG1 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/28377:smg9 ^@ http://purl.uniprot.org/uniprot/H9G947 ^@ Similarity ^@ Belongs to the SMG9 family. http://togogenome.org/gene/28377:LOC100555056 ^@ http://purl.uniprot.org/uniprot/A0A803T209 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/28377:LOC100554943 ^@ http://purl.uniprot.org/uniprot/G1KP03 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/28377:dmbx1 ^@ http://purl.uniprot.org/uniprot/G1KA14 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:fam175b ^@ http://purl.uniprot.org/uniprot/A0A803TYQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM175 family. Abro1 subfamily.|||Nucleus|||spindle pole http://togogenome.org/gene/28377:LOC100558930 ^@ http://purl.uniprot.org/uniprot/G1KPV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/28377:fam105a ^@ http://purl.uniprot.org/uniprot/G1KEE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/28377:etv6 ^@ http://purl.uniprot.org/uniprot/G1KD30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/28377:pigf ^@ http://purl.uniprot.org/uniprot/R4GDJ8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:mtmr7 ^@ http://purl.uniprot.org/uniprot/G1KFD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/28377:erg ^@ http://purl.uniprot.org/uniprot/G1KIN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/28377:LOC100556911 ^@ http://purl.uniprot.org/uniprot/H9GL58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM132 family.|||Membrane http://togogenome.org/gene/28377:serinc5 ^@ http://purl.uniprot.org/uniprot/G1KSQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/28377:kiz ^@ http://purl.uniprot.org/uniprot/R4GBP1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the kizuna family.|||Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.|||centrosome|||cilium basal body http://togogenome.org/gene/28377:lgr5 ^@ http://purl.uniprot.org/uniprot/G1KGE4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:tnfsf14 ^@ http://purl.uniprot.org/uniprot/A0A803SYA8 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/28377:LOC100565025 ^@ http://purl.uniprot.org/uniprot/G1KMU6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/28377:jag2 ^@ http://purl.uniprot.org/uniprot/A0A803THM0|||http://purl.uniprot.org/uniprot/G1KJ33 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/28377:jph2 ^@ http://purl.uniprot.org/uniprot/G1KT07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/28377:tbcc ^@ http://purl.uniprot.org/uniprot/G1K8N1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCC family.|||Cytoplasm|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. http://togogenome.org/gene/28377:wdr55 ^@ http://purl.uniprot.org/uniprot/A0A803T2B8|||http://purl.uniprot.org/uniprot/A0A803U189 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR55 family.|||Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.|||nucleolus http://togogenome.org/gene/28377:rad21 ^@ http://purl.uniprot.org/uniprot/G1KKS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/28377:lmod3 ^@ http://purl.uniprot.org/uniprot/G1KR11 ^@ Subcellular Location Annotation ^@ cytoskeleton|||sarcomere http://togogenome.org/gene/28377:adssl1 ^@ http://purl.uniprot.org/uniprot/G1KLI8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.|||Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. http://togogenome.org/gene/28377:fam98a ^@ http://purl.uniprot.org/uniprot/G1KIY3 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/28377:ints7 ^@ http://purl.uniprot.org/uniprot/G1KFM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 7 family.|||Nucleus http://togogenome.org/gene/28377:galnt12 ^@ http://purl.uniprot.org/uniprot/G1KAJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:atg2b ^@ http://purl.uniprot.org/uniprot/G1KNQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG2 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Preautophagosomal structure membrane http://togogenome.org/gene/28377:scml4 ^@ http://purl.uniprot.org/uniprot/G1KEN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/28377:grem1 ^@ http://purl.uniprot.org/uniprot/G1KRN7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:ctnna1 ^@ http://purl.uniprot.org/uniprot/A0A803STG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction http://togogenome.org/gene/28377:ccdc167 ^@ http://purl.uniprot.org/uniprot/A0A803SVT8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:mrpl2 ^@ http://purl.uniprot.org/uniprot/G1KDM8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/28377:usp16 ^@ http://purl.uniprot.org/uniprot/G1K9U0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. USP16 subfamily.|||Homotetramer.|||Nucleus|||Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.|||The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin. http://togogenome.org/gene/28377:ckap2 ^@ http://purl.uniprot.org/uniprot/G1KT45 ^@ Similarity ^@ Belongs to the CKAP2 family. http://togogenome.org/gene/28377:mrps33 ^@ http://purl.uniprot.org/uniprot/A0A803TD31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/28377:gem ^@ http://purl.uniprot.org/uniprot/G1KC41 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/28377:proz ^@ http://purl.uniprot.org/uniprot/G1K8D2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:mrpl50 ^@ http://purl.uniprot.org/uniprot/A0A803TXV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL50 family.|||Mitochondrion http://togogenome.org/gene/28377:dgkg ^@ http://purl.uniprot.org/uniprot/A0A803TJA8|||http://purl.uniprot.org/uniprot/A0A803TU05|||http://purl.uniprot.org/uniprot/G1KHJ2 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/28377:LOC103279322 ^@ http://purl.uniprot.org/uniprot/H9GQT4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:aarsd1 ^@ http://purl.uniprot.org/uniprot/R4GCQ3 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily. http://togogenome.org/gene/28377:rnpep ^@ http://purl.uniprot.org/uniprot/G1KCJ3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/28377:LOC100556198 ^@ http://purl.uniprot.org/uniprot/G1KT72 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/28377:mapt ^@ http://purl.uniprot.org/uniprot/A0A803TSA1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||axon|||cytoskeleton|||cytosol|||dendrite http://togogenome.org/gene/28377:tyk2 ^@ http://purl.uniprot.org/uniprot/G1KHZ7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. http://togogenome.org/gene/28377:LOC100564569 ^@ http://purl.uniprot.org/uniprot/L7MZU4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:srd5a1 ^@ http://purl.uniprot.org/uniprot/R4GBJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.|||Membrane|||Microsome membrane http://togogenome.org/gene/28377:lmbr1 ^@ http://purl.uniprot.org/uniprot/G1KKY1 ^@ Similarity ^@ Belongs to the LIMR family. http://togogenome.org/gene/28377:exosc9 ^@ http://purl.uniprot.org/uniprot/G1KMQ7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/28377:amigo1 ^@ http://purl.uniprot.org/uniprot/G1KKN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/28377:vps36 ^@ http://purl.uniprot.org/uniprot/G1KT38 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS36 family.|||Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II).|||Cytoplasm|||Endosome http://togogenome.org/gene/28377:bche ^@ http://purl.uniprot.org/uniprot/A0A803T8U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Secreted http://togogenome.org/gene/28377:tmeff1 ^@ http://purl.uniprot.org/uniprot/G1K9W6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:tspan12 ^@ http://purl.uniprot.org/uniprot/G1KG80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/28377:lin7b ^@ http://purl.uniprot.org/uniprot/A0A803TWT8|||http://purl.uniprot.org/uniprot/G1KNG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-7 family.|||Cell junction|||Cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. http://togogenome.org/gene/28377:srprb ^@ http://purl.uniprot.org/uniprot/A0A803SSR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP receptor beta subunit family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:scml2 ^@ http://purl.uniprot.org/uniprot/G1KLD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/28377:nr1h2 ^@ http://purl.uniprot.org/uniprot/G1KMJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/28377:tada1 ^@ http://purl.uniprot.org/uniprot/G1KR84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TADA1 family.|||Nucleus|||Probably involved in transcriptional regulation. http://togogenome.org/gene/28377:atg4d ^@ http://purl.uniprot.org/uniprot/G1KS12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/28377:LOC100568176 ^@ http://purl.uniprot.org/uniprot/G1KBS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/28377:elk1 ^@ http://purl.uniprot.org/uniprot/G1KD37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/28377:tram1 ^@ http://purl.uniprot.org/uniprot/G1KQI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/28377:LOC100560702 ^@ http://purl.uniprot.org/uniprot/G1KQE7 ^@ Similarity ^@ Belongs to the JAKMIP family. http://togogenome.org/gene/28377:wnt3 ^@ http://purl.uniprot.org/uniprot/G1KSX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/28377:gabpa ^@ http://purl.uniprot.org/uniprot/G1KQE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/28377:atp6v1g2 ^@ http://purl.uniprot.org/uniprot/G1KLZ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/28377:ttc4 ^@ http://purl.uniprot.org/uniprot/G1KQ35 ^@ Similarity ^@ Belongs to the TTC4 family. http://togogenome.org/gene/28377:amotl2 ^@ http://purl.uniprot.org/uniprot/G1KJ49 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/28377:ildr2 ^@ http://purl.uniprot.org/uniprot/A0A803SNM3|||http://purl.uniprot.org/uniprot/A0A803SPT2|||http://purl.uniprot.org/uniprot/A0A803TGJ6|||http://purl.uniprot.org/uniprot/G1KJ80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. LISCH7 family.|||Membrane|||tight junction http://togogenome.org/gene/28377:mrpl43 ^@ http://purl.uniprot.org/uniprot/A0A803TAI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL43 family.|||Mitochondrion http://togogenome.org/gene/28377:dpys ^@ http://purl.uniprot.org/uniprot/G1KJD0 ^@ PTM|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Carbamylation allows a single lysine to coordinate two divalent metal cations. http://togogenome.org/gene/28377:psmc1 ^@ http://purl.uniprot.org/uniprot/G1KQ45 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/28377:bcor ^@ http://purl.uniprot.org/uniprot/G1KPY3 ^@ Similarity ^@ Belongs to the BCOR family. http://togogenome.org/gene/28377:LOC100565436 ^@ http://purl.uniprot.org/uniprot/G1KAM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acyl-CoA reductase family.|||Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.|||Peroxisome membrane http://togogenome.org/gene/28377:LOC100337546 ^@ http://purl.uniprot.org/uniprot/B6Z1W6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:alox5ap ^@ http://purl.uniprot.org/uniprot/A0A803STA1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:tgfb2 ^@ http://purl.uniprot.org/uniprot/G1K950 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/28377:crispld1 ^@ http://purl.uniprot.org/uniprot/G1KNF4 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/28377:ppard ^@ http://purl.uniprot.org/uniprot/G1KAH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/28377:LOC100566097 ^@ http://purl.uniprot.org/uniprot/A0A803T806 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:LOC100564706 ^@ http://purl.uniprot.org/uniprot/G1KL94 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/28377:spop ^@ http://purl.uniprot.org/uniprot/G1KDC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tdpoz family.|||Nucleus speckle http://togogenome.org/gene/28377:fam161a ^@ http://purl.uniprot.org/uniprot/G1KE87 ^@ Similarity ^@ Belongs to the FAM161 family. http://togogenome.org/gene/28377:grm1 ^@ http://purl.uniprot.org/uniprot/A0A803T4R7|||http://purl.uniprot.org/uniprot/G1KGH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:osbpl2 ^@ http://purl.uniprot.org/uniprot/G1KD33 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/28377:fam126a ^@ http://purl.uniprot.org/uniprot/A0A803TCX7|||http://purl.uniprot.org/uniprot/G1KPE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/28377:gcgr ^@ http://purl.uniprot.org/uniprot/G1KKF1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100565550 ^@ http://purl.uniprot.org/uniprot/A0A803SN84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/28377:hrh1 ^@ http://purl.uniprot.org/uniprot/G1KJV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:tmem106c ^@ http://purl.uniprot.org/uniprot/A0A803T5Z9 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/28377:asph ^@ http://purl.uniprot.org/uniprot/A0A803SZY2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:nrp1 ^@ http://purl.uniprot.org/uniprot/G1KFQ6 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:rack1 ^@ http://purl.uniprot.org/uniprot/G1KLU0 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. http://togogenome.org/gene/28377:aifm2 ^@ http://purl.uniprot.org/uniprot/G1KUD7 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. FIG1 subfamily. http://togogenome.org/gene/28377:grb7 ^@ http://purl.uniprot.org/uniprot/A0A803SMR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/28377:oxsr1 ^@ http://purl.uniprot.org/uniprot/G1KJI2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/28377:aqp5 ^@ http://purl.uniprot.org/uniprot/G1KHU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/28377:plpp1 ^@ http://purl.uniprot.org/uniprot/A0A803SRP0|||http://purl.uniprot.org/uniprot/A0A803TNL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/28377:LOC100553238 ^@ http://purl.uniprot.org/uniprot/G1KXX7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/28377:dlgap2 ^@ http://purl.uniprot.org/uniprot/G1KDV0 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/28377:LOC100562074 ^@ http://purl.uniprot.org/uniprot/A0A803TKC8|||http://purl.uniprot.org/uniprot/G1KN24 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.|||Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. http://togogenome.org/gene/28377:ccdc67 ^@ http://purl.uniprot.org/uniprot/G1KQC6 ^@ Similarity ^@ Belongs to the CEP63 family. http://togogenome.org/gene/28377:sypl1 ^@ http://purl.uniprot.org/uniprot/G1KQ57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/28377:coq6 ^@ http://purl.uniprot.org/uniprot/G1KSA9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UbiH/COQ6 family.|||Belongs to the flavin monoamine oxidase family. FIG1 subfamily.|||Cell projection|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.|||FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.|||Golgi apparatus|||Mitochondrion inner membrane http://togogenome.org/gene/28377:xylb ^@ http://purl.uniprot.org/uniprot/G1KM28 ^@ Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. http://togogenome.org/gene/28377:ttc39c ^@ http://purl.uniprot.org/uniprot/G1K992 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/28377:asah1 ^@ http://purl.uniprot.org/uniprot/G1KFU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acid ceramidase family.|||Lysosome http://togogenome.org/gene/28377:cnnm1 ^@ http://purl.uniprot.org/uniprot/G1KC03 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ACDP family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Metal transporter. http://togogenome.org/gene/28377:LOC100567051 ^@ http://purl.uniprot.org/uniprot/G1KW33 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:atl2 ^@ http://purl.uniprot.org/uniprot/A0A803TLX0|||http://purl.uniprot.org/uniprot/G1KQ36 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/28377:dclk3 ^@ http://purl.uniprot.org/uniprot/G1KJT0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/28377:itga9 ^@ http://purl.uniprot.org/uniprot/G1KJB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/28377:chmp4c ^@ http://purl.uniprot.org/uniprot/G1KP71 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/28377:foxn3 ^@ http://purl.uniprot.org/uniprot/A0A803T9F9|||http://purl.uniprot.org/uniprot/G1KMS5 ^@ Function|||Subcellular Location Annotation ^@ Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).|||Nucleus http://togogenome.org/gene/28377:snx6 ^@ http://purl.uniprot.org/uniprot/A0A803T4I4 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/28377:rln3 ^@ http://purl.uniprot.org/uniprot/A0A803SY97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/28377:kif3a ^@ http://purl.uniprot.org/uniprot/A0A803T2I2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/28377:LOC100557857 ^@ http://purl.uniprot.org/uniprot/A0A803SQ92 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/28377:cnot10 ^@ http://purl.uniprot.org/uniprot/G1KQD7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT10 family.|||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:igfbp1 ^@ http://purl.uniprot.org/uniprot/G1KHC0 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds equally well IGF1 and IGF2.|||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:atg101 ^@ http://purl.uniprot.org/uniprot/A0A803TH95 ^@ Similarity ^@ Belongs to the ATG101 family. http://togogenome.org/gene/28377:aqr ^@ http://purl.uniprot.org/uniprot/G1K915 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CWF11 family.|||Nucleus http://togogenome.org/gene/28377:bcap31 ^@ http://purl.uniprot.org/uniprot/G1KI14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.|||Membrane http://togogenome.org/gene/28377:adipor2 ^@ http://purl.uniprot.org/uniprot/G1K856 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/28377:oaf ^@ http://purl.uniprot.org/uniprot/H9G7J5 ^@ Similarity ^@ Belongs to the OAF family. http://togogenome.org/gene/28377:pgr ^@ http://purl.uniprot.org/uniprot/G1KP48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/28377:galk1 ^@ http://purl.uniprot.org/uniprot/G1KGC6 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/28377:lrrc8e ^@ http://purl.uniprot.org/uniprot/G1KJG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:parp1 ^@ http://purl.uniprot.org/uniprot/G1KFB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARTD/PARP family.|||Chromosome|||Nucleus|||Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. http://togogenome.org/gene/28377:LOC100563136 ^@ http://purl.uniprot.org/uniprot/R4G9Q4 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/28377:memo1 ^@ http://purl.uniprot.org/uniprot/A0A803T1B3 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/28377:qrsl1 ^@ http://purl.uniprot.org/uniprot/G1KEK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/28377:mon1a ^@ http://purl.uniprot.org/uniprot/G1KHU2 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/28377:nr0b1 ^@ http://purl.uniprot.org/uniprot/A0A803T644 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:rad9a ^@ http://purl.uniprot.org/uniprot/G1KHD3 ^@ Similarity ^@ Belongs to the rad9 family. http://togogenome.org/gene/28377:fam109b ^@ http://purl.uniprot.org/uniprot/G1KCC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sesquipedalian family.|||Early endosome|||Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.|||Recycling endosome|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/28377:xkr9 ^@ http://purl.uniprot.org/uniprot/G1KQA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/28377:ndnf ^@ http://purl.uniprot.org/uniprot/G1KN23 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/28377:kiaa1147 ^@ http://purl.uniprot.org/uniprot/G1KL73 ^@ Similarity ^@ Belongs to the DENND11 family. http://togogenome.org/gene/28377:dlc1 ^@ http://purl.uniprot.org/uniprot/A0A803T732|||http://purl.uniprot.org/uniprot/A0A803TK68|||http://purl.uniprot.org/uniprot/G1KI70 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/28377:dpy19l1 ^@ http://purl.uniprot.org/uniprot/A0A803SQ63|||http://purl.uniprot.org/uniprot/G1KGN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/28377:pycr1 ^@ http://purl.uniprot.org/uniprot/G1KK19 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/28377:cep57 ^@ http://purl.uniprot.org/uniprot/G1KP63 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/28377:scgn ^@ http://purl.uniprot.org/uniprot/G1K9J9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/28377:LOC100566597 ^@ http://purl.uniprot.org/uniprot/G1KCJ4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/28377:ctbp2 ^@ http://purl.uniprot.org/uniprot/A0A803SWG4|||http://purl.uniprot.org/uniprot/A0A803TNR1|||http://purl.uniprot.org/uniprot/G1KQ30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/28377:atp2b1 ^@ http://purl.uniprot.org/uniprot/A0A803TUD6|||http://purl.uniprot.org/uniprot/G1KM20 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:b4galnt4 ^@ http://purl.uniprot.org/uniprot/G1KNR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane|||Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. http://togogenome.org/gene/28377:sf3b5 ^@ http://purl.uniprot.org/uniprot/G1KH75 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SF3B5 family.|||Component of the spliceosome B complex.|||Nucleus http://togogenome.org/gene/28377:arl14 ^@ http://purl.uniprot.org/uniprot/G1KGE8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/28377:keap1 ^@ http://purl.uniprot.org/uniprot/G1KID3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KEAP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:fbln5 ^@ http://purl.uniprot.org/uniprot/G1KIX9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:ccng1 ^@ http://purl.uniprot.org/uniprot/G1KQ42 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/28377:dok3 ^@ http://purl.uniprot.org/uniprot/G1KEU3 ^@ Similarity ^@ Belongs to the DOK family. Type A subfamily. http://togogenome.org/gene/28377:LOC100558455 ^@ http://purl.uniprot.org/uniprot/G1KT34 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/28377:galr1 ^@ http://purl.uniprot.org/uniprot/G1KE48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/28377:LOC100565755 ^@ http://purl.uniprot.org/uniprot/G1KM15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/28377:neurod6 ^@ http://purl.uniprot.org/uniprot/G1KJ70 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:guf1 ^@ http://purl.uniprot.org/uniprot/G1KG38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. LepA subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Mitochondrion inner membrane|||Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. http://togogenome.org/gene/28377:LOC100556910 ^@ http://purl.uniprot.org/uniprot/A0A803T9G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:lmod2 ^@ http://purl.uniprot.org/uniprot/G1K8X9 ^@ Subcellular Location Annotation ^@ cytoskeleton|||sarcomere http://togogenome.org/gene/28377:a4galt ^@ http://purl.uniprot.org/uniprot/G1KS37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 32 family.|||Golgi apparatus membrane http://togogenome.org/gene/28377:scp2 ^@ http://purl.uniprot.org/uniprot/G1KHY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the thiolase-like superfamily. Thiolase family.|||Cytoplasm|||Mitochondrion http://togogenome.org/gene/28377:LOC100559058 ^@ http://purl.uniprot.org/uniprot/G1KYN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spire family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/28377:LOC100554861 ^@ http://purl.uniprot.org/uniprot/G1KFS6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/28377:lsm14b ^@ http://purl.uniprot.org/uniprot/A0A803T3X9|||http://purl.uniprot.org/uniprot/G1KSA2 ^@ Similarity ^@ Belongs to the LSM14 family. http://togogenome.org/gene/28377:fam19a3 ^@ http://purl.uniprot.org/uniprot/A0A803SL83 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/28377:tyr ^@ http://purl.uniprot.org/uniprot/G1KQJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/28377:tmem198 ^@ http://purl.uniprot.org/uniprot/G1KPM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane http://togogenome.org/gene/28377:mrps5 ^@ http://purl.uniprot.org/uniprot/G1K8V8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/28377:parl ^@ http://purl.uniprot.org/uniprot/G1KD18 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:LOC100566411 ^@ http://purl.uniprot.org/uniprot/G1KFQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/28377:col4a3bp ^@ http://purl.uniprot.org/uniprot/A0A803TFU0|||http://purl.uniprot.org/uniprot/G1KI18 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Golgi apparatus http://togogenome.org/gene/28377:as3mt ^@ http://purl.uniprot.org/uniprot/R4G9E3 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Arsenite methyltransferase family. http://togogenome.org/gene/28377:dpy30 ^@ http://purl.uniprot.org/uniprot/G1K8Q1 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/28377:pparg ^@ http://purl.uniprot.org/uniprot/G1KNP4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Cytoplasm|||Heterodimer with other nuclear receptors.|||Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.|||Nucleus http://togogenome.org/gene/28377:pi16 ^@ http://purl.uniprot.org/uniprot/A0A803TV37 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/28377:LOC100556256 ^@ http://purl.uniprot.org/uniprot/A0A803T3S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Membrane|||Microsome membrane http://togogenome.org/gene/28377:LOC100565491 ^@ http://purl.uniprot.org/uniprot/G1KCL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/28377:ncoa3 ^@ http://purl.uniprot.org/uniprot/G1KSL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/28377:LOC100556508 ^@ http://purl.uniprot.org/uniprot/G1KV96 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:dnal4 ^@ http://purl.uniprot.org/uniprot/G1KH53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/28377:LOC103278936 ^@ http://purl.uniprot.org/uniprot/G1KHA5 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/28377:tmem27 ^@ http://purl.uniprot.org/uniprot/G1KTF4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100564964 ^@ http://purl.uniprot.org/uniprot/G1KN22 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/28377:dcn ^@ http://purl.uniprot.org/uniprot/G1KM87 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.|||May affect the rate of fibrils formation.|||extracellular matrix http://togogenome.org/gene/28377:tcp1 ^@ http://purl.uniprot.org/uniprot/A0A803TJF7 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/28377:ampd2 ^@ http://purl.uniprot.org/uniprot/A0A803SSN3|||http://purl.uniprot.org/uniprot/A0A803SYK8|||http://purl.uniprot.org/uniprot/A0A803THQ2|||http://purl.uniprot.org/uniprot/G1KLF1 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/28377:tctn3 ^@ http://purl.uniprot.org/uniprot/G1KCU2 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/28377:pnpo ^@ http://purl.uniprot.org/uniprot/G1KFQ7 ^@ Function|||Similarity ^@ Belongs to the pyridoxamine 5'-phosphate oxidase family.|||Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). http://togogenome.org/gene/28377:LOC100555331 ^@ http://purl.uniprot.org/uniprot/G1KG10 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family. Snake venom subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:rpl27 ^@ http://purl.uniprot.org/uniprot/G1KNX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL27 family.|||Endoplasmic reticulum|||Rough endoplasmic reticulum http://togogenome.org/gene/28377:ptpn2 ^@ http://purl.uniprot.org/uniprot/R4G923 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. http://togogenome.org/gene/28377:mcm9 ^@ http://purl.uniprot.org/uniprot/A0A803TKV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/28377:pclo ^@ http://purl.uniprot.org/uniprot/A0A803TK82|||http://purl.uniprot.org/uniprot/G1KS77 ^@ Subcellular Location Annotation ^@ Presynaptic active zone http://togogenome.org/gene/28377:cdc37l1 ^@ http://purl.uniprot.org/uniprot/G1KC11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/28377:dpysl4 ^@ http://purl.uniprot.org/uniprot/G1KH68 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/28377:hsdl1 ^@ http://purl.uniprot.org/uniprot/A0A803SVI5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:cpn1 ^@ http://purl.uniprot.org/uniprot/G1KCP4 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/28377:glyctk ^@ http://purl.uniprot.org/uniprot/G1KFJ3 ^@ Similarity ^@ Belongs to the glycerate kinase type-2 family. http://togogenome.org/gene/28377:esrrb ^@ http://purl.uniprot.org/uniprot/G1KTH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/28377:tube1 ^@ http://purl.uniprot.org/uniprot/G1KLK0 ^@ Similarity ^@ Belongs to the tubulin family. http://togogenome.org/gene/28377:atp6v0e1 ^@ http://purl.uniprot.org/uniprot/G1KQR8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/28377:ace2 ^@ http://purl.uniprot.org/uniprot/G1KTF3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M2 family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Cytoplasm|||Membrane|||Secreted|||cilium http://togogenome.org/gene/28377:smc5 ^@ http://purl.uniprot.org/uniprot/A0A803SYB1|||http://purl.uniprot.org/uniprot/G1K8W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC5 subfamily.|||Nucleus http://togogenome.org/gene/28377:ibsp ^@ http://purl.uniprot.org/uniprot/G1KML5 ^@ Function|||Subcellular Location Annotation ^@ Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.|||Secreted http://togogenome.org/gene/28377:gatad1 ^@ http://purl.uniprot.org/uniprot/A0A803TAW1|||http://purl.uniprot.org/uniprot/G1KR66 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:hmgcr ^@ http://purl.uniprot.org/uniprot/G1KI99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMG-CoA reductase family.|||Endoplasmic reticulum membrane|||Membrane|||Peroxisome membrane http://togogenome.org/gene/28377:dhps ^@ http://purl.uniprot.org/uniprot/G1KCS7 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/28377:fam151b ^@ http://purl.uniprot.org/uniprot/G1KK61 ^@ Similarity ^@ Belongs to the FAM151 family. http://togogenome.org/gene/28377:LOC100554797 ^@ http://purl.uniprot.org/uniprot/G1KZB8 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:adcy6 ^@ http://purl.uniprot.org/uniprot/G1KHZ6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/28377:tmbim1 ^@ http://purl.uniprot.org/uniprot/A0A803SWD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/28377:otop2 ^@ http://purl.uniprot.org/uniprot/G1KER1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:lect1 ^@ http://purl.uniprot.org/uniprot/G1K8K4 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/28377:g6pc3 ^@ http://purl.uniprot.org/uniprot/G1KCY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/28377:gpr35 ^@ http://purl.uniprot.org/uniprot/G1KX02 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:LOC100551610 ^@ http://purl.uniprot.org/uniprot/G1KLW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/28377:LOC100563808 ^@ http://purl.uniprot.org/uniprot/G1KUF8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:ptdss1 ^@ http://purl.uniprot.org/uniprot/G1KCP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphatidyl serine synthase family.|||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:itpr2 ^@ http://purl.uniprot.org/uniprot/G1KLX9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the InsP3 receptor family.|||Endoplasmic reticulum membrane|||Homotetramer.|||Membrane|||Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.|||The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. http://togogenome.org/gene/28377:krt36 ^@ http://purl.uniprot.org/uniprot/B6Z1W3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:plk2 ^@ http://purl.uniprot.org/uniprot/G1KIX7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/28377:parp8 ^@ http://purl.uniprot.org/uniprot/G1KCX2 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/28377:ppp4r3a ^@ http://purl.uniprot.org/uniprot/G1KJ53 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/28377:ntsr1 ^@ http://purl.uniprot.org/uniprot/G1KX65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:eif4ebp2 ^@ http://purl.uniprot.org/uniprot/G1KHQ0 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/28377:epyc ^@ http://purl.uniprot.org/uniprot/G1KM57 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/28377:csnk1a1 ^@ http://purl.uniprot.org/uniprot/A0A803TT69|||http://purl.uniprot.org/uniprot/G1KRF6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/28377:esrrg ^@ http://purl.uniprot.org/uniprot/A0A803T607|||http://purl.uniprot.org/uniprot/A0A803TAH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/28377:fundc1 ^@ http://purl.uniprot.org/uniprot/A0A803TNZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/28377:LOC100567116 ^@ http://purl.uniprot.org/uniprot/A0A803TQX0 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/28377:ppp1r10 ^@ http://purl.uniprot.org/uniprot/G1KKH3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers. http://togogenome.org/gene/28377:dph3 ^@ http://purl.uniprot.org/uniprot/G1KGZ9 ^@ Similarity ^@ Belongs to the DPH3 family. http://togogenome.org/gene/28377:LOC100562152 ^@ http://purl.uniprot.org/uniprot/G1KDJ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/28377:fam3a ^@ http://purl.uniprot.org/uniprot/G1KDG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/28377:hnf4a ^@ http://purl.uniprot.org/uniprot/G1KT65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/28377:c2h2orf88 ^@ http://purl.uniprot.org/uniprot/A0A803TNT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small membrane AKAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:acy3 ^@ http://purl.uniprot.org/uniprot/G1KHW7 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/28377:atp11a ^@ http://purl.uniprot.org/uniprot/A0A803ST26|||http://purl.uniprot.org/uniprot/G1KFM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/28377:LOC103279038 ^@ http://purl.uniprot.org/uniprot/R4G9B2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/28377:alg2 ^@ http://purl.uniprot.org/uniprot/G1KIF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.|||Membrane http://togogenome.org/gene/28377:zdhhc21 ^@ http://purl.uniprot.org/uniprot/G1KUE0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/28377:stx11 ^@ http://purl.uniprot.org/uniprot/G1KH73 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/28377:xrcc1 ^@ http://purl.uniprot.org/uniprot/H9G8R9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:LOC100562920 ^@ http://purl.uniprot.org/uniprot/A0A803T106|||http://purl.uniprot.org/uniprot/G1KCM0 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/28377:fbln1 ^@ http://purl.uniprot.org/uniprot/G1KQ48 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the fibulin family.|||Homomultimerizes and interacts with various extracellular matrix components.|||Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/28377:atat1 ^@ http://purl.uniprot.org/uniprot/G1KKM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase ATAT1 family.|||Cytoplasm|||Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. May be involved in neuron development.|||axon|||clathrin-coated pit|||cytoskeleton|||focal adhesion|||spindle http://togogenome.org/gene/28377:prom1 ^@ http://purl.uniprot.org/uniprot/A0A803SU19|||http://purl.uniprot.org/uniprot/G1KMB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/28377:emc2 ^@ http://purl.uniprot.org/uniprot/A0A803SRQ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC2 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. http://togogenome.org/gene/28377:phkb ^@ http://purl.uniprot.org/uniprot/A0A803SMZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. http://togogenome.org/gene/28377:pcyt1b ^@ http://purl.uniprot.org/uniprot/A0A803TAZ9|||http://purl.uniprot.org/uniprot/G1KG28 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/28377:osbpl1a ^@ http://purl.uniprot.org/uniprot/A0A803T9U9|||http://purl.uniprot.org/uniprot/G1K9P2 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/28377:pard3 ^@ http://purl.uniprot.org/uniprot/A0A803SRN1|||http://purl.uniprot.org/uniprot/G1K955 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR3 family.|||Cell junction|||Endomembrane system http://togogenome.org/gene/28377:tpd52 ^@ http://purl.uniprot.org/uniprot/A0A803SVF2 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/28377:ace ^@ http://purl.uniprot.org/uniprot/G1KNF0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M2 family.|||Binds 2 Zn(2+) ions per subunit. http://togogenome.org/gene/28377:LOC100552272 ^@ http://purl.uniprot.org/uniprot/A0A803TZX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNF-like-inhibitor family.|||Secreted http://togogenome.org/gene/28377:LOC100555455 ^@ http://purl.uniprot.org/uniprot/G1KGN7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/28377:apaf1 ^@ http://purl.uniprot.org/uniprot/G1KNE2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Monomer. Oligomerizes upon binding of cytochrome c and dATP.|||Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. http://togogenome.org/gene/28377:sesn3 ^@ http://purl.uniprot.org/uniprot/G1KPC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/28377:LOC100561560 ^@ http://purl.uniprot.org/uniprot/G1KAI2 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/28377:anxa3 ^@ http://purl.uniprot.org/uniprot/G1KFA2 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/28377:srd5a3 ^@ http://purl.uniprot.org/uniprot/G1KJ34 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).|||Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. http://togogenome.org/gene/28377:stc2 ^@ http://purl.uniprot.org/uniprot/A0A803TK18 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/28377:LOC100552532 ^@ http://purl.uniprot.org/uniprot/A0A803T5K5|||http://purl.uniprot.org/uniprot/G1KP27 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/28377:LOC100551988 ^@ http://purl.uniprot.org/uniprot/A0A803SXH3 ^@ Similarity ^@ Belongs to the peptidase S1 family. Snake venom subfamily. http://togogenome.org/gene/28377:hnrnpd ^@ http://purl.uniprot.org/uniprot/A0A803T0C8|||http://purl.uniprot.org/uniprot/G1KK21 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/28377:agl ^@ http://purl.uniprot.org/uniprot/A0A803SN98|||http://purl.uniprot.org/uniprot/G1KCM2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycogen debranching enzyme family.|||Cytoplasm|||Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. http://togogenome.org/gene/28377:tie1 ^@ http://purl.uniprot.org/uniprot/G1KNK3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:xpc ^@ http://purl.uniprot.org/uniprot/A0A803STU8|||http://purl.uniprot.org/uniprot/G1KNY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPC family.|||Nucleus http://togogenome.org/gene/28377:LOC103278888 ^@ http://purl.uniprot.org/uniprot/A0A803TTX2 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/28377:LOC100562739 ^@ http://purl.uniprot.org/uniprot/G1KL23 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/28377:add3 ^@ http://purl.uniprot.org/uniprot/A0A803T5Y7|||http://purl.uniprot.org/uniprot/G1KF70 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/28377:LOC100566752 ^@ http://purl.uniprot.org/uniprot/G1KUK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:pdgfb ^@ http://purl.uniprot.org/uniprot/R4GCL3 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/28377:LOC100553709 ^@ http://purl.uniprot.org/uniprot/G1KLF6 ^@ Similarity ^@ Belongs to the GST superfamily. Mu family. http://togogenome.org/gene/28377:elavl3 ^@ http://purl.uniprot.org/uniprot/A0A803T4P2|||http://purl.uniprot.org/uniprot/A0A803T6G8 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/28377:fgd1 ^@ http://purl.uniprot.org/uniprot/A0A803SWV0 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/28377:chaf1b ^@ http://purl.uniprot.org/uniprot/G1KMQ3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:kcnq2 ^@ http://purl.uniprot.org/uniprot/A0A803TM57 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/28377:tyms ^@ http://purl.uniprot.org/uniprot/G1KHU7 ^@ Similarity ^@ Belongs to the thymidylate synthase family. http://togogenome.org/gene/28377:rp2 ^@ http://purl.uniprot.org/uniprot/G1KLV0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.|||Belongs to the TBCC family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:vil1 ^@ http://purl.uniprot.org/uniprot/G1KAJ0 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/28377:LOC100566883 ^@ http://purl.uniprot.org/uniprot/V5ZDW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/28377:hmces ^@ http://purl.uniprot.org/uniprot/G1KEX9 ^@ Function|||Similarity ^@ Belongs to the SOS response-associated peptidase family.|||Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction. http://togogenome.org/gene/28377:chst13 ^@ http://purl.uniprot.org/uniprot/A0A803SZN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:smad9 ^@ http://purl.uniprot.org/uniprot/G1KCU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:LOC100565510 ^@ http://purl.uniprot.org/uniprot/G1KW90 ^@ Similarity ^@ Belongs to the histone deacetylase family. HD type 2 subfamily. http://togogenome.org/gene/28377:inha ^@ http://purl.uniprot.org/uniprot/A0A803T6Y0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.|||Secreted http://togogenome.org/gene/28377:sphkap ^@ http://purl.uniprot.org/uniprot/G1KQD8 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/28377:spic ^@ http://purl.uniprot.org/uniprot/A0A803SW30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/28377:LOC100562756 ^@ http://purl.uniprot.org/uniprot/G1KII1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/28377:actrt3 ^@ http://purl.uniprot.org/uniprot/G1KRF3 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/28377:ampd1 ^@ http://purl.uniprot.org/uniprot/A0A803SSR9|||http://purl.uniprot.org/uniprot/G1KBG7 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/28377:msx2 ^@ http://purl.uniprot.org/uniprot/G1KQK2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:c3hxorf36 ^@ http://purl.uniprot.org/uniprot/G1KUG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/28377:LOC100567848 ^@ http://purl.uniprot.org/uniprot/G1KAW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/28377:grn ^@ http://purl.uniprot.org/uniprot/G1KLY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the granulin family.|||Secreted http://togogenome.org/gene/28377:sema5a ^@ http://purl.uniprot.org/uniprot/G1KK42 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:ube3a ^@ http://purl.uniprot.org/uniprot/G1KLV9 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.|||Nucleus http://togogenome.org/gene/28377:actr8 ^@ http://purl.uniprot.org/uniprot/G1KLI9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin family. ARP8 subfamily.|||Chromosome|||Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.|||Nucleus|||Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.|||Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. http://togogenome.org/gene/28377:ppp1cb ^@ http://purl.uniprot.org/uniprot/G1KIW6 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-1 subfamily. http://togogenome.org/gene/28377:LOC100567780 ^@ http://purl.uniprot.org/uniprot/G1KMS7 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/28377:LOC100560626 ^@ http://purl.uniprot.org/uniprot/G1KMQ2 ^@ Similarity ^@ Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. http://togogenome.org/gene/28377:pdk3 ^@ http://purl.uniprot.org/uniprot/G1KG97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/28377:LOC100559118 ^@ http://purl.uniprot.org/uniprot/A0A803SM81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/28377:serinc1 ^@ http://purl.uniprot.org/uniprot/G1K9H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/28377:twf2 ^@ http://purl.uniprot.org/uniprot/G1KFM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||cytoskeleton http://togogenome.org/gene/28377:yae1d1 ^@ http://purl.uniprot.org/uniprot/A0A803SKX8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/28377:rpl9 ^@ http://purl.uniprot.org/uniprot/G1KGG6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/28377:gpr6 ^@ http://purl.uniprot.org/uniprot/G1KXE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:ndel1 ^@ http://purl.uniprot.org/uniprot/A0A803T1I2|||http://purl.uniprot.org/uniprot/A0A803TFN2|||http://purl.uniprot.org/uniprot/G1KU53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||spindle http://togogenome.org/gene/28377:acadsb ^@ http://purl.uniprot.org/uniprot/G1KU01 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/28377:sdad1 ^@ http://purl.uniprot.org/uniprot/G1KMV0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDA1 family.|||Required for 60S pre-ribosomal subunits export to the cytoplasm.|||nucleolus http://togogenome.org/gene/28377:slc7a2 ^@ http://purl.uniprot.org/uniprot/G1KFG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:vta1 ^@ http://purl.uniprot.org/uniprot/G1KHT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTA1 family.|||Cytoplasm|||Endosome membrane|||Membrane http://togogenome.org/gene/28377:p4hb ^@ http://purl.uniprot.org/uniprot/G1KKB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/28377:cul2 ^@ http://purl.uniprot.org/uniprot/A0A803U060|||http://purl.uniprot.org/uniprot/G1K8W4 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/28377:LOC103279063 ^@ http://purl.uniprot.org/uniprot/A0A803TQS8 ^@ Similarity ^@ Belongs to the FAM47 family. http://togogenome.org/gene/28377:nup205 ^@ http://purl.uniprot.org/uniprot/G1KL92 ^@ Similarity ^@ Belongs to the NUP186/NUP192/NUP205 family. http://togogenome.org/gene/28377:LOC100559672 ^@ http://purl.uniprot.org/uniprot/H9GHD5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:thnsl1 ^@ http://purl.uniprot.org/uniprot/G1KHW5 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/28377:fam83d ^@ http://purl.uniprot.org/uniprot/A0A803SS20 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/28377:arl1 ^@ http://purl.uniprot.org/uniprot/G1KLB7 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/28377:tmem63c ^@ http://purl.uniprot.org/uniprot/R4GD55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/28377:fam208a ^@ http://purl.uniprot.org/uniprot/A0A803SLZ1|||http://purl.uniprot.org/uniprot/A0A803SYN9|||http://purl.uniprot.org/uniprot/G1KER4 ^@ Similarity ^@ Belongs to the TASOR family. http://togogenome.org/gene/28377:plekha8 ^@ http://purl.uniprot.org/uniprot/R4GC20 ^@ Subcellular Location Annotation ^@ trans-Golgi network membrane http://togogenome.org/gene/28377:foxn2 ^@ http://purl.uniprot.org/uniprot/G1KPN1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:arpc4 ^@ http://purl.uniprot.org/uniprot/G1KJF3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARPC4 family.|||Cell projection|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.|||cytoskeleton http://togogenome.org/gene/28377:tdrd5 ^@ http://purl.uniprot.org/uniprot/G1KVT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDRD5 family.|||Cytoplasm http://togogenome.org/gene/28377:aco2 ^@ http://purl.uniprot.org/uniprot/G1KD44 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.|||Mitochondrion http://togogenome.org/gene/28377:gga3 ^@ http://purl.uniprot.org/uniprot/G1KFC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/28377:LOC100558055 ^@ http://purl.uniprot.org/uniprot/R4GA71 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:pir ^@ http://purl.uniprot.org/uniprot/G1KM88 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/28377:ifrd1 ^@ http://purl.uniprot.org/uniprot/A0A803TZK1 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/28377:pde6h ^@ http://purl.uniprot.org/uniprot/G1KUR7 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/28377:scoc ^@ http://purl.uniprot.org/uniprot/A0A803TNR8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SCOC family.|||Positive regulator of amino acid starvation-induced autophagy.|||trans-Golgi network http://togogenome.org/gene/28377:dlgap4 ^@ http://purl.uniprot.org/uniprot/G1KJD8 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/28377:pln ^@ http://purl.uniprot.org/uniprot/G1KUA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phospholamban family.|||Endoplasmic reticulum membrane|||Homopentamer.|||Membrane|||Mitochondrion membrane|||Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/28377:gjc2 ^@ http://purl.uniprot.org/uniprot/G1KFU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/28377:krt23 ^@ http://purl.uniprot.org/uniprot/R4GBD3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:flt3 ^@ http://purl.uniprot.org/uniprot/G1KIN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Membrane http://togogenome.org/gene/28377:slc35a4 ^@ http://purl.uniprot.org/uniprot/G1KN33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:tmed1 ^@ http://purl.uniprot.org/uniprot/G1KR35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/28377:tmem255b ^@ http://purl.uniprot.org/uniprot/G1K8H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM255 family.|||Membrane http://togogenome.org/gene/28377:nsa2 ^@ http://purl.uniprot.org/uniprot/A0A803TW35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.|||nucleolus http://togogenome.org/gene/28377:pdk4 ^@ http://purl.uniprot.org/uniprot/G1KPJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/28377:rab3gap2 ^@ http://purl.uniprot.org/uniprot/G1K9V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab3-GAP regulatory subunit family.|||Cytoplasm http://togogenome.org/gene/28377:LOC100557659 ^@ http://purl.uniprot.org/uniprot/G1KS43 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/28377:kif2c ^@ http://purl.uniprot.org/uniprot/G1KQF7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/28377:map3k12 ^@ http://purl.uniprot.org/uniprot/G1K8Z9 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||May be an activator of the JNK/SAPK pathway. http://togogenome.org/gene/28377:arhgdib ^@ http://purl.uniprot.org/uniprot/G1KKK5 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/28377:LOC100555786 ^@ http://purl.uniprot.org/uniprot/A0A803TLL5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family. Snake venom subfamily.|||Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:prox1 ^@ http://purl.uniprot.org/uniprot/G1KF25 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:hip1r ^@ http://purl.uniprot.org/uniprot/H9GMU9 ^@ Similarity ^@ Belongs to the SLA2 family. http://togogenome.org/gene/28377:LOC100554659 ^@ http://purl.uniprot.org/uniprot/A0A803TSU9 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:LOC100551807 ^@ http://purl.uniprot.org/uniprot/G1KKI8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.|||Belongs to the osteocalcin/matrix Gla protein family.|||Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.|||Requires vitamin K-dependent gamma-carboxylation for its function.|||Secreted http://togogenome.org/gene/28377:LOC100563852 ^@ http://purl.uniprot.org/uniprot/G1KRH4 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. FIG1 subfamily. http://togogenome.org/gene/28377:ston1 ^@ http://purl.uniprot.org/uniprot/G1KPS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Stoned B family.|||Cytoplasm|||May be involved in the endocytic machinery. http://togogenome.org/gene/28377:LOC100555997 ^@ http://purl.uniprot.org/uniprot/R4GB47 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/28377:spin1 ^@ http://purl.uniprot.org/uniprot/A0A803TWI7 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/28377:sparc ^@ http://purl.uniprot.org/uniprot/A0A803T5M1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|||Belongs to the SPARC family.|||Membrane|||basement membrane http://togogenome.org/gene/28377:gpm6b ^@ http://purl.uniprot.org/uniprot/A0A803SPU6|||http://purl.uniprot.org/uniprot/A0A803TEX1|||http://purl.uniprot.org/uniprot/A0A803TXP0|||http://purl.uniprot.org/uniprot/G1KA16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/28377:LOC100337549 ^@ http://purl.uniprot.org/uniprot/B6Z1W2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:fam110b ^@ http://purl.uniprot.org/uniprot/G1KDW0 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/28377:tph2 ^@ http://purl.uniprot.org/uniprot/G1KGT8 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/28377:rps27a ^@ http://purl.uniprot.org/uniprot/G1KBR8 ^@ Similarity ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/28377:arsj ^@ http://purl.uniprot.org/uniprot/G1KLJ8 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/28377:tmem131 ^@ http://purl.uniprot.org/uniprot/G1KM90 ^@ Similarity ^@ Belongs to the TMEM131 family. http://togogenome.org/gene/28377:esyt3 ^@ http://purl.uniprot.org/uniprot/G1KJ31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:rh2 ^@ http://purl.uniprot.org/uniprot/P51471|||http://purl.uniprot.org/uniprot/Q549F5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore.|||Membrane|||Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.|||Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. This opsin uses a vitamin A2 chromophore. http://togogenome.org/gene/28377:slc25a13 ^@ http://purl.uniprot.org/uniprot/A0A803U1E6|||http://purl.uniprot.org/uniprot/G1KQ55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/28377:cartpt ^@ http://purl.uniprot.org/uniprot/G1KJH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CART family.|||Secreted http://togogenome.org/gene/28377:unc5c ^@ http://purl.uniprot.org/uniprot/G1KPC0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/28377:dazl ^@ http://purl.uniprot.org/uniprot/G1KH34 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/28377:gal ^@ http://purl.uniprot.org/uniprot/A0A803TG73|||http://purl.uniprot.org/uniprot/G1KPK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the galanin family.|||Secreted http://togogenome.org/gene/28377:plppr5 ^@ http://purl.uniprot.org/uniprot/A0A803SQD6|||http://purl.uniprot.org/uniprot/R4GDG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/28377:ccr6 ^@ http://purl.uniprot.org/uniprot/G1KK39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/28377:exoc7 ^@ http://purl.uniprot.org/uniprot/A0A803TV19|||http://purl.uniprot.org/uniprot/G1KHD7 ^@ Function|||Similarity ^@ Belongs to the EXO70 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/28377:pde8b ^@ http://purl.uniprot.org/uniprot/G1KH36 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/28377:zfyve27 ^@ http://purl.uniprot.org/uniprot/A0A803TFU6|||http://purl.uniprot.org/uniprot/G1KBH4 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Recycling endosome membrane|||growth cone membrane http://togogenome.org/gene/28377:apex2 ^@ http://purl.uniprot.org/uniprot/G1KKZ7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/28377:ythdf1 ^@ http://purl.uniprot.org/uniprot/G1KE89 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/28377:cpsf2 ^@ http://purl.uniprot.org/uniprot/G1KIP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/28377:il12b ^@ http://purl.uniprot.org/uniprot/G1KRP1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-12B family.|||Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.|||Secreted http://togogenome.org/gene/28377:cndp1 ^@ http://purl.uniprot.org/uniprot/G1KC31 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/28377:amer2 ^@ http://purl.uniprot.org/uniprot/G1KBR9 ^@ Similarity ^@ Belongs to the Amer family. http://togogenome.org/gene/28377:sec63 ^@ http://purl.uniprot.org/uniprot/G1KET9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:pfkl ^@ http://purl.uniprot.org/uniprot/G1KID2 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homo- and heterotetramers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:mterf1 ^@ http://purl.uniprot.org/uniprot/G1KRK0 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/28377:tdrd9 ^@ http://purl.uniprot.org/uniprot/G1KKN5 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. http://togogenome.org/gene/28377:anapc11 ^@ http://purl.uniprot.org/uniprot/A0A803TAQ8 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/28377:optc ^@ http://purl.uniprot.org/uniprot/G1KA92 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/28377:mical3 ^@ http://purl.uniprot.org/uniprot/G1KMJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mical family.|||Belongs to the flavin monoamine oxidase family. FIG1 subfamily.|||Cytoplasm http://togogenome.org/gene/28377:plin2 ^@ http://purl.uniprot.org/uniprot/A0A803SXS3 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/28377:mov10 ^@ http://purl.uniprot.org/uniprot/G1KUK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.|||P-body http://togogenome.org/gene/28377:dph5 ^@ http://purl.uniprot.org/uniprot/A0A803TD74 ^@ Function|||Similarity ^@ Belongs to the diphthine synthase family.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/28377:spcs3 ^@ http://purl.uniprot.org/uniprot/A0A803T7V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS3 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:slc11a1 ^@ http://purl.uniprot.org/uniprot/A0A803TML1|||http://purl.uniprot.org/uniprot/G1KA06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAMP family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/28377:znf277 ^@ http://purl.uniprot.org/uniprot/G1KG84 ^@ Similarity ^@ Belongs to the ZNF277 family. http://togogenome.org/gene/28377:cntnap5 ^@ http://purl.uniprot.org/uniprot/G1KFB1 ^@ Caution|||Similarity ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:LOC103279307 ^@ http://purl.uniprot.org/uniprot/A0A803T107 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/28377:kcnj13 ^@ http://purl.uniprot.org/uniprot/G1KFD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/28377:tmem9b ^@ http://purl.uniprot.org/uniprot/G1KJE7 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/28377:dhfr ^@ http://purl.uniprot.org/uniprot/G1KK77 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/28377:LOC103278063 ^@ http://purl.uniprot.org/uniprot/A0A803TLI2 ^@ Function|||Similarity ^@ Belongs to the ohanin/vespryn family.|||Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal. http://togogenome.org/gene/28377:st6gal1 ^@ http://purl.uniprot.org/uniprot/A0A803TN77|||http://purl.uniprot.org/uniprot/E4ZFG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/28377:atg16l1 ^@ http://purl.uniprot.org/uniprot/A0A803TQB0|||http://purl.uniprot.org/uniprot/G1KF02|||http://purl.uniprot.org/uniprot/R4G9G5 ^@ Similarity ^@ Belongs to the WD repeat ATG16 family. http://togogenome.org/gene/28377:LOC100562609 ^@ http://purl.uniprot.org/uniprot/G1KG25 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/28377:denr ^@ http://purl.uniprot.org/uniprot/H9GMV2 ^@ Similarity ^@ Belongs to the DENR family. http://togogenome.org/gene/28377:nek3 ^@ http://purl.uniprot.org/uniprot/G1KT47 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/28377:spdef ^@ http://purl.uniprot.org/uniprot/G1KRL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/28377:ccdc39 ^@ http://purl.uniprot.org/uniprot/G1KCH7 ^@ Similarity ^@ Belongs to the CCDC39 family. http://togogenome.org/gene/28377:rnf13 ^@ http://purl.uniprot.org/uniprot/G1KGV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:dhrs7c ^@ http://purl.uniprot.org/uniprot/G1KTB0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:lpcat2 ^@ http://purl.uniprot.org/uniprot/H9GNF5 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/28377:itgb8 ^@ http://purl.uniprot.org/uniprot/A0A803U1L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:slco5a1 ^@ http://purl.uniprot.org/uniprot/G1KQU4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:tp53inp2 ^@ http://purl.uniprot.org/uniprot/A0A803SME6 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/28377:st3gal3 ^@ http://purl.uniprot.org/uniprot/A0A803TVM0|||http://purl.uniprot.org/uniprot/A0A803U022 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/28377:slc6a7 ^@ http://purl.uniprot.org/uniprot/G1KQY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/28377:fam216b ^@ http://purl.uniprot.org/uniprot/A0A803TS19 ^@ Similarity ^@ Belongs to the FAM216 family. http://togogenome.org/gene/28377:rdx ^@ http://purl.uniprot.org/uniprot/A0A803T3G2 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/28377:amhr2 ^@ http://purl.uniprot.org/uniprot/A0A803TUX2|||http://purl.uniprot.org/uniprot/G1K8P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Secreted http://togogenome.org/gene/28377:prdx1 ^@ http://purl.uniprot.org/uniprot/G1KQP3 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/28377:pnpla6 ^@ http://purl.uniprot.org/uniprot/A0A803SM78|||http://purl.uniprot.org/uniprot/A0A803SQF2|||http://purl.uniprot.org/uniprot/A0A803T3X5|||http://purl.uniprot.org/uniprot/G1KSE9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NTE family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:rbm12 ^@ http://purl.uniprot.org/uniprot/G1KF90 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/28377:snrpc ^@ http://purl.uniprot.org/uniprot/A0A803TGH4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/28377:sfmbt2 ^@ http://purl.uniprot.org/uniprot/G1KDI2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:taf5l ^@ http://purl.uniprot.org/uniprot/G1K983 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/28377:LOC100553963 ^@ http://purl.uniprot.org/uniprot/G1KVL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/28377:LOC100564897 ^@ http://purl.uniprot.org/uniprot/L7MZZ1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/28377:foxj1 ^@ http://purl.uniprot.org/uniprot/G1KHE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FOXJ1 family.|||Nucleus http://togogenome.org/gene/28377:avpr1a ^@ http://purl.uniprot.org/uniprot/G1K8H6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:mmp16 ^@ http://purl.uniprot.org/uniprot/A0A803TPW0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/28377:eya1 ^@ http://purl.uniprot.org/uniprot/A0A803SRT0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/28377:LOC100553362 ^@ http://purl.uniprot.org/uniprot/R4G9M8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:kpna5 ^@ http://purl.uniprot.org/uniprot/G1KPI9 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/28377:renbp ^@ http://purl.uniprot.org/uniprot/G1KM50 ^@ Similarity ^@ Belongs to the N-acylglucosamine 2-epimerase family. http://togogenome.org/gene/28377:tm4sf18 ^@ http://purl.uniprot.org/uniprot/G1KGP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/28377:c1h11orf58 ^@ http://purl.uniprot.org/uniprot/G1K872 ^@ Similarity ^@ Belongs to the SMAP family. http://togogenome.org/gene/28377:hexim1 ^@ http://purl.uniprot.org/uniprot/G1KSF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HEXIM family.|||Nucleus http://togogenome.org/gene/28377:sh3bgrl2 ^@ http://purl.uniprot.org/uniprot/G1KTW0 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/28377:tmsb4x ^@ http://purl.uniprot.org/uniprot/A0A803STT6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/28377:entpd1 ^@ http://purl.uniprot.org/uniprot/G1KCT1 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/28377:paqr3 ^@ http://purl.uniprot.org/uniprot/G1KFE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/28377:grb2 ^@ http://purl.uniprot.org/uniprot/G1KFH8 ^@ Subcellular Location Annotation ^@ Endosome|||Golgi apparatus|||Nucleus http://togogenome.org/gene/28377:itpk1 ^@ http://purl.uniprot.org/uniprot/G1KI84 ^@ Similarity ^@ Belongs to the ITPK1 family. http://togogenome.org/gene/28377:nmu ^@ http://purl.uniprot.org/uniprot/R4GCU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NmU family.|||Secreted http://togogenome.org/gene/28377:cog6 ^@ http://purl.uniprot.org/uniprot/G1KSU3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COG6 family.|||Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.|||Golgi apparatus membrane|||Membrane|||Required for normal Golgi function. http://togogenome.org/gene/28377:anapc13 ^@ http://purl.uniprot.org/uniprot/A0A803TP20 ^@ Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. http://togogenome.org/gene/28377:mcoln1 ^@ http://purl.uniprot.org/uniprot/G1KSG8 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/28377:acot13 ^@ http://purl.uniprot.org/uniprot/G1KAI0 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/28377:sult4a1 ^@ http://purl.uniprot.org/uniprot/G1KSC5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/28377:kcnq3 ^@ http://purl.uniprot.org/uniprot/A0A803TYN1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100557568 ^@ http://purl.uniprot.org/uniprot/R4GBG5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/28377:LOC100564195 ^@ http://purl.uniprot.org/uniprot/A0A803TR93 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/28377:snx7 ^@ http://purl.uniprot.org/uniprot/G1K8N3 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/28377:nr2c1 ^@ http://purl.uniprot.org/uniprot/G1KMY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/28377:banf2 ^@ http://purl.uniprot.org/uniprot/R4G921 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:hyal1 ^@ http://purl.uniprot.org/uniprot/G1KX26 ^@ Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 56 family.|||Monomer. http://togogenome.org/gene/28377:ahcy ^@ http://purl.uniprot.org/uniprot/G1KIL2 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/28377:tulp4 ^@ http://purl.uniprot.org/uniprot/R4GA07 ^@ Similarity ^@ Belongs to the TUB family. http://togogenome.org/gene/28377:nudt6 ^@ http://purl.uniprot.org/uniprot/G1KLL0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family.|||Cytoplasm|||May contribute to the regulation of cell proliferation.|||Mitochondrion|||Monomer and homodimer.|||Nucleus http://togogenome.org/gene/28377:satb1 ^@ http://purl.uniprot.org/uniprot/A0A803STW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/28377:adrm1 ^@ http://purl.uniprot.org/uniprot/A0A803TX70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADRM1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:LOC100553620 ^@ http://purl.uniprot.org/uniprot/G1KGT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:gdf5 ^@ http://purl.uniprot.org/uniprot/G1KEJ5 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/28377:LOC100567378 ^@ http://purl.uniprot.org/uniprot/A0A803TPN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:nkx2-3 ^@ http://purl.uniprot.org/uniprot/A0A803TB06 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:fh ^@ http://purl.uniprot.org/uniprot/G1KJB7 ^@ Function|||Similarity ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. http://togogenome.org/gene/28377:raf1 ^@ http://purl.uniprot.org/uniprot/G1KNI7|||http://purl.uniprot.org/uniprot/R4G9F6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/28377:cs ^@ http://purl.uniprot.org/uniprot/G1KGV0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the citrate synthase family.|||Homodimer.|||Mitochondrion matrix http://togogenome.org/gene/28377:alg5 ^@ http://purl.uniprot.org/uniprot/G1KU96 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/28377:bmt2 ^@ http://purl.uniprot.org/uniprot/G1KG09 ^@ Function|||Similarity|||Subunit ^@ Belongs to the BMT2 family.|||Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.|||S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/28377:sema4g ^@ http://purl.uniprot.org/uniprot/G1KCD5 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:mettl6 ^@ http://purl.uniprot.org/uniprot/G1KB69 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/28377:gmppb ^@ http://purl.uniprot.org/uniprot/G1KGR0 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/28377:LOC100563850 ^@ http://purl.uniprot.org/uniprot/G1KJR4 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/28377:gldc ^@ http://purl.uniprot.org/uniprot/G1KCW2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvP family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/28377:mfsd14a ^@ http://purl.uniprot.org/uniprot/G1KC18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/28377:thra ^@ http://purl.uniprot.org/uniprot/G1KBE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/28377:abcd2 ^@ http://purl.uniprot.org/uniprot/G1KHF9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:wdyhv1 ^@ http://purl.uniprot.org/uniprot/G1KJ74 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NTAQ1 family.|||Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.|||Monomer. http://togogenome.org/gene/28377:ano9 ^@ http://purl.uniprot.org/uniprot/G1KXW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:plxnb1 ^@ http://purl.uniprot.org/uniprot/G1KK91 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:vldlr ^@ http://purl.uniprot.org/uniprot/A0A803SME3|||http://purl.uniprot.org/uniprot/G1KBI9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:hus1 ^@ http://purl.uniprot.org/uniprot/G1KHF0 ^@ Similarity ^@ Belongs to the HUS1 family. http://togogenome.org/gene/28377:clic5 ^@ http://purl.uniprot.org/uniprot/G1KN71 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/28377:LOC100558155 ^@ http://purl.uniprot.org/uniprot/H9GKW3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:tle4 ^@ http://purl.uniprot.org/uniprot/G1KBE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/28377:drd3 ^@ http://purl.uniprot.org/uniprot/G1KJF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.|||Membrane http://togogenome.org/gene/28377:cacng2 ^@ http://purl.uniprot.org/uniprot/A0A803SKV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. http://togogenome.org/gene/28377:slc35a3 ^@ http://purl.uniprot.org/uniprot/G1KC60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:cdc6 ^@ http://purl.uniprot.org/uniprot/G1KAT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC6/cdc18 family.|||Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.|||Nucleus http://togogenome.org/gene/28377:LOC100561946 ^@ http://purl.uniprot.org/uniprot/G1KUY8 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/28377:slc39a13 ^@ http://purl.uniprot.org/uniprot/G1KAR5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:LOC100554941 ^@ http://purl.uniprot.org/uniprot/G1KZ17 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/28377:rnf168 ^@ http://purl.uniprot.org/uniprot/A0A803U145 ^@ Caution|||Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNF168 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs). http://togogenome.org/gene/28377:ddb2 ^@ http://purl.uniprot.org/uniprot/A0A803SLK1|||http://purl.uniprot.org/uniprot/G1KBJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DDB2/WDR76 family.|||Nucleus http://togogenome.org/gene/28377:csrnp2 ^@ http://purl.uniprot.org/uniprot/G1KMA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/28377:ptdss2 ^@ http://purl.uniprot.org/uniprot/G1KNZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphatidyl serine synthase family.|||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:nt5c3a ^@ http://purl.uniprot.org/uniprot/A0A803T217|||http://purl.uniprot.org/uniprot/G1KIT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/28377:gata6 ^@ http://purl.uniprot.org/uniprot/G1KH24 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:ca8 ^@ http://purl.uniprot.org/uniprot/G1KEH4 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/28377:ndufaf7 ^@ http://purl.uniprot.org/uniprot/A0A803TGP0|||http://purl.uniprot.org/uniprot/G1K9D5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Belongs to the NDUFAF7 family.|||Mitochondrion http://togogenome.org/gene/28377:cnot6 ^@ http://purl.uniprot.org/uniprot/G1KSS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCR4/nocturin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:harbi1 ^@ http://purl.uniprot.org/uniprot/G1KCG8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HARBI1 family.|||Cytoplasm|||Nucleus|||Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity. http://togogenome.org/gene/28377:ssr4 ^@ http://purl.uniprot.org/uniprot/G1KL41 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-delta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/28377:pomk ^@ http://purl.uniprot.org/uniprot/G1KIL5 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. http://togogenome.org/gene/28377:smarca2 ^@ http://purl.uniprot.org/uniprot/A0A803T3G4|||http://purl.uniprot.org/uniprot/G1KBB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/28377:npepps ^@ http://purl.uniprot.org/uniprot/G1KGF3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/28377:lasp1 ^@ http://purl.uniprot.org/uniprot/A0A803T8G4 ^@ Function|||Subcellular Location Annotation ^@ Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.|||cell cortex|||cytoskeleton http://togogenome.org/gene/28377:uts2r ^@ http://purl.uniprot.org/uniprot/G1KL43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.|||Membrane http://togogenome.org/gene/28377:pld5 ^@ http://purl.uniprot.org/uniprot/G1KBT8 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/28377:slc16a1 ^@ http://purl.uniprot.org/uniprot/G1KUK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/28377:atp4b ^@ http://purl.uniprot.org/uniprot/A0A803SWM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/28377:rps6ka2 ^@ http://purl.uniprot.org/uniprot/A0A803T4Z7|||http://purl.uniprot.org/uniprot/A0A803U1V0|||http://purl.uniprot.org/uniprot/G1KR88 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/28377:p2rx3 ^@ http://purl.uniprot.org/uniprot/G1KGM4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/28377:spdya ^@ http://purl.uniprot.org/uniprot/G1KIS1 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/28377:tbx21 ^@ http://purl.uniprot.org/uniprot/A0A803TLA0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/28377:rbm10 ^@ http://purl.uniprot.org/uniprot/G1KEN8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:LOC100558251 ^@ http://purl.uniprot.org/uniprot/G1KKD4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:trmt13 ^@ http://purl.uniprot.org/uniprot/G1KBZ1 ^@ Function|||Similarity ^@ Belongs to the methyltransferase TRM13 family.|||tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). http://togogenome.org/gene/28377:syt2 ^@ http://purl.uniprot.org/uniprot/G1KCC0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||synaptic vesicle membrane http://togogenome.org/gene/28377:gosr2 ^@ http://purl.uniprot.org/uniprot/A0A803TWJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOSR2 family.|||Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.|||Membrane http://togogenome.org/gene/28377:nab1 ^@ http://purl.uniprot.org/uniprot/G1K8C5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAB family.|||Homomultimers may associate with EGR1 bound to DNA.|||Nucleus http://togogenome.org/gene/28377:c5h4orf47 ^@ http://purl.uniprot.org/uniprot/G1KA78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP96 family.|||centrosome http://togogenome.org/gene/28377:myt1 ^@ http://purl.uniprot.org/uniprot/A0A803T6M7|||http://purl.uniprot.org/uniprot/A0A803TZJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYT1 family.|||Nucleus http://togogenome.org/gene/28377:tshz1 ^@ http://purl.uniprot.org/uniprot/A0A803SYG0 ^@ Similarity ^@ Belongs to the teashirt C2H2-type zinc-finger protein family. http://togogenome.org/gene/28377:slf2 ^@ http://purl.uniprot.org/uniprot/A0A803THV6|||http://purl.uniprot.org/uniprot/A0A803U0A0 ^@ Similarity ^@ Belongs to the FAM178 family. http://togogenome.org/gene/28377:aqp4 ^@ http://purl.uniprot.org/uniprot/G1KAC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/28377:odf2l ^@ http://purl.uniprot.org/uniprot/A0A803TLG9|||http://purl.uniprot.org/uniprot/G1KPI8|||http://purl.uniprot.org/uniprot/G1KYP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||centrosome http://togogenome.org/gene/28377:atp5h ^@ http://purl.uniprot.org/uniprot/G1KEZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase d subunit family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/28377:kdm4a ^@ http://purl.uniprot.org/uniprot/G1KPP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM3 histone demethylase family.|||Nucleus http://togogenome.org/gene/28377:LOC100555644 ^@ http://purl.uniprot.org/uniprot/A0A803T4S2 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/28377:ednra ^@ http://purl.uniprot.org/uniprot/G1KCC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/28377:vangl1 ^@ http://purl.uniprot.org/uniprot/G1KBK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:slc25a20 ^@ http://purl.uniprot.org/uniprot/G1KLX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/28377:lyplal1 ^@ http://purl.uniprot.org/uniprot/A0A803TKH0 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/28377:dusp5 ^@ http://purl.uniprot.org/uniprot/G1KEU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/28377:tsfm ^@ http://purl.uniprot.org/uniprot/G1KN68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Mitochondrion http://togogenome.org/gene/28377:brpf1 ^@ http://purl.uniprot.org/uniprot/G1KJR0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:txnl4a ^@ http://purl.uniprot.org/uniprot/G1K996 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/28377:mpped1 ^@ http://purl.uniprot.org/uniprot/A0A803SMV2 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/28377:LOC100555256 ^@ http://purl.uniprot.org/uniprot/G1KJG4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:tamm41 ^@ http://purl.uniprot.org/uniprot/R4G9U2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAM41 family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Mitochondrion inner membrane http://togogenome.org/gene/28377:plg ^@ http://purl.uniprot.org/uniprot/G1KBV2 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Belongs to the peptidase S1 family. Snake venom subfamily.|||Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.|||Secreted http://togogenome.org/gene/28377:galm ^@ http://purl.uniprot.org/uniprot/G1KEZ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the aldose epimerase family.|||Monomer.|||Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. http://togogenome.org/gene/28377:bok ^@ http://purl.uniprot.org/uniprot/G1K8X4 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/28377:tsnax ^@ http://purl.uniprot.org/uniprot/A0A803TBT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the translin family.|||Nucleus http://togogenome.org/gene/28377:fam98b ^@ http://purl.uniprot.org/uniprot/G1KRU8 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/28377:slc35c1 ^@ http://purl.uniprot.org/uniprot/G1KQ38 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:irx4 ^@ http://purl.uniprot.org/uniprot/G1K8P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/28377:st3gal6 ^@ http://purl.uniprot.org/uniprot/A0A803TMM1|||http://purl.uniprot.org/uniprot/G1KKN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/28377:LOC100564767 ^@ http://purl.uniprot.org/uniprot/G1KHE2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:taf4 ^@ http://purl.uniprot.org/uniprot/G1KSB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF4 family.|||Nucleus http://togogenome.org/gene/28377:LOC100553977 ^@ http://purl.uniprot.org/uniprot/H9G8Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNF-like-inhibitor family.|||Secreted http://togogenome.org/gene/28377:sdc1 ^@ http://purl.uniprot.org/uniprot/G1KK50 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/28377:apopt1 ^@ http://purl.uniprot.org/uniprot/A0A803TQD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COA8 family.|||Mitochondrion inner membrane http://togogenome.org/gene/28377:kmt5b ^@ http://purl.uniprot.org/uniprot/A0A803TAG6 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/28377:ppm1l ^@ http://purl.uniprot.org/uniprot/G1KXV5 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/28377:triqk ^@ http://purl.uniprot.org/uniprot/G1KBV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIQK family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:LOC100564371 ^@ http://purl.uniprot.org/uniprot/P41592 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane|||Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.|||Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. This opsin uses a vitamin A2 chromophore. http://togogenome.org/gene/28377:cfi ^@ http://purl.uniprot.org/uniprot/G1KJP9 ^@ Caution|||Similarity ^@ Belongs to the peptidase S1 family. Snake venom subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:agxt ^@ http://purl.uniprot.org/uniprot/G1KG79 ^@ Similarity|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/28377:LOC100553180 ^@ http://purl.uniprot.org/uniprot/G1KIY1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:lrp6 ^@ http://purl.uniprot.org/uniprot/G1KD13 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the LDLR family.|||Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.|||Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:LOC100554488 ^@ http://purl.uniprot.org/uniprot/G1KLP8 ^@ Similarity ^@ Belongs to the GST superfamily. Mu family. http://togogenome.org/gene/28377:rft1 ^@ http://purl.uniprot.org/uniprot/G1KHQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RFT1 family.|||May be involved in N-linked oligosaccharide assembly.|||Membrane http://togogenome.org/gene/28377:atp10a ^@ http://purl.uniprot.org/uniprot/G1KLR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/28377:LOC100564498 ^@ http://purl.uniprot.org/uniprot/G1KM80 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/28377:mrpl3 ^@ http://purl.uniprot.org/uniprot/G1K9Q3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/28377:c8a ^@ http://purl.uniprot.org/uniprot/G1KFV6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:aars2 ^@ http://purl.uniprot.org/uniprot/G1KQ51 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/28377:api5 ^@ http://purl.uniprot.org/uniprot/G1KRG2 ^@ Similarity ^@ Belongs to the API5 family. http://togogenome.org/gene/28377:LOC100564317 ^@ http://purl.uniprot.org/uniprot/G1KCM9 ^@ Similarity ^@ Belongs to the RRM TRSPAP family. http://togogenome.org/gene/28377:nobox ^@ http://purl.uniprot.org/uniprot/G1KA94 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:imp4 ^@ http://purl.uniprot.org/uniprot/G1KET8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/28377:napb ^@ http://purl.uniprot.org/uniprot/A0A803T190|||http://purl.uniprot.org/uniprot/G1KQP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/28377:slc30a9 ^@ http://purl.uniprot.org/uniprot/G1KLV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Endoplasmic reticulum|||Membrane|||Mitochondrion membrane|||Nucleus http://togogenome.org/gene/28377:ebf3 ^@ http://purl.uniprot.org/uniprot/G1KI56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/28377:vwde ^@ http://purl.uniprot.org/uniprot/G1KV13 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:LOC100566795 ^@ http://purl.uniprot.org/uniprot/G1KLM2 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. FIG1 subfamily. http://togogenome.org/gene/28377:exo1 ^@ http://purl.uniprot.org/uniprot/G1KBV4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.|||Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Nucleus http://togogenome.org/gene/28377:tubgcp6 ^@ http://purl.uniprot.org/uniprot/G1KAD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||centrosome http://togogenome.org/gene/28377:mtnr1b ^@ http://purl.uniprot.org/uniprot/A0A803T9J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:pdk2 ^@ http://purl.uniprot.org/uniprot/G1KE56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/28377:nck2 ^@ http://purl.uniprot.org/uniprot/G1KK46 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/28377:jun ^@ http://purl.uniprot.org/uniprot/G1KG27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/28377:poc5 ^@ http://purl.uniprot.org/uniprot/G1KHQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POC5 family.|||Essential for the assembly of the distal half of centrioles, required for centriole elongation.|||centriole http://togogenome.org/gene/28377:dtx3l ^@ http://purl.uniprot.org/uniprot/G1KJ94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/28377:ing3 ^@ http://purl.uniprot.org/uniprot/G1KG43 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/28377:tfap2d ^@ http://purl.uniprot.org/uniprot/G1KDY1 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/28377:crh ^@ http://purl.uniprot.org/uniprot/G1KSW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/28377:c5h6orf120 ^@ http://purl.uniprot.org/uniprot/G1KEF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0669 family.|||Secreted http://togogenome.org/gene/28377:vwc2 ^@ http://purl.uniprot.org/uniprot/G1KHG8 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/28377:slc12a4 ^@ http://purl.uniprot.org/uniprot/H9GFF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/28377:rb1 ^@ http://purl.uniprot.org/uniprot/G1KBZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the retinoblastoma protein (RB) family.|||Nucleus http://togogenome.org/gene/28377:atp5f1 ^@ http://purl.uniprot.org/uniprot/A0A803STE8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ATPase B chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/28377:edem1 ^@ http://purl.uniprot.org/uniprot/G1KMD7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/28377:slc44a2 ^@ http://purl.uniprot.org/uniprot/A0A803TA58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/28377:vars2 ^@ http://purl.uniprot.org/uniprot/G1KUT8 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/28377:fam134b ^@ http://purl.uniprot.org/uniprot/A0A803TJN1|||http://purl.uniprot.org/uniprot/G1K8F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:sgo1 ^@ http://purl.uniprot.org/uniprot/G1K849 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||centromere http://togogenome.org/gene/28377:hmx2 ^@ http://purl.uniprot.org/uniprot/G1KU05 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:bcat1 ^@ http://purl.uniprot.org/uniprot/A0A803SL94|||http://purl.uniprot.org/uniprot/G1KTU1 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/28377:LOC100552579 ^@ http://purl.uniprot.org/uniprot/G1KP83 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/28377:LOC100562367 ^@ http://purl.uniprot.org/uniprot/G1KLK9 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/28377:npc2 ^@ http://purl.uniprot.org/uniprot/A0A803SML8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPC2 family.|||Secreted http://togogenome.org/gene/28377:irak1bp1 ^@ http://purl.uniprot.org/uniprot/G1KD55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRAK1BP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:sypl2 ^@ http://purl.uniprot.org/uniprot/G1KKM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/28377:gpr180 ^@ http://purl.uniprot.org/uniprot/G1KAU1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:igf2bp3 ^@ http://purl.uniprot.org/uniprot/G1KNZ3 ^@ Similarity ^@ Belongs to the RRM IMP/VICKZ family. http://togogenome.org/gene/28377:fzd6 ^@ http://purl.uniprot.org/uniprot/G1KIU5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:fam198b ^@ http://purl.uniprot.org/uniprot/G1KST9 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/28377:pla2g15 ^@ http://purl.uniprot.org/uniprot/A0A803SWS5 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/28377:rgn ^@ http://purl.uniprot.org/uniprot/G1KLQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm http://togogenome.org/gene/28377:bicd1 ^@ http://purl.uniprot.org/uniprot/G1KMR4 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/28377:ing5 ^@ http://purl.uniprot.org/uniprot/G1K8N5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/28377:gjd4 ^@ http://purl.uniprot.org/uniprot/A0A803TXK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/28377:LOC100565290 ^@ http://purl.uniprot.org/uniprot/A0A803SYQ0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/28377:LOC100557734 ^@ http://purl.uniprot.org/uniprot/G1KE38 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:lrp8 ^@ http://purl.uniprot.org/uniprot/A0A803TC95|||http://purl.uniprot.org/uniprot/G1KI88 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:sfmbt1 ^@ http://purl.uniprot.org/uniprot/G1KHN7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:trappc6b ^@ http://purl.uniprot.org/uniprot/G1KRS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/28377:acyp1 ^@ http://purl.uniprot.org/uniprot/G1KT64 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/28377:frk ^@ http://purl.uniprot.org/uniprot/G1KMB1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/28377:ccdc103 ^@ http://purl.uniprot.org/uniprot/G1KGU9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC103/PR46b family.|||Cytoplasm|||Dynein-attachment factor required for cilia motility.|||Homodimer.|||flagellum http://togogenome.org/gene/28377:mdh1 ^@ http://purl.uniprot.org/uniprot/G1KET7 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family.|||Homodimer. http://togogenome.org/gene/28377:htr5a ^@ http://purl.uniprot.org/uniprot/G1KKP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100557661 ^@ http://purl.uniprot.org/uniprot/G1KDK9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/28377:gsx2 ^@ http://purl.uniprot.org/uniprot/G1KX04 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:rpl7 ^@ http://purl.uniprot.org/uniprot/G1KPV4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/28377:slc25a40 ^@ http://purl.uniprot.org/uniprot/R4GA36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/28377:mrpl18 ^@ http://purl.uniprot.org/uniprot/G1KCN2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL18 family. http://togogenome.org/gene/28377:LOC100337544 ^@ http://purl.uniprot.org/uniprot/B6Z1W4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:kiaa0196 ^@ http://purl.uniprot.org/uniprot/G1KJY7 ^@ Similarity ^@ Belongs to the strumpellin family. http://togogenome.org/gene/28377:tgfbr1 ^@ http://purl.uniprot.org/uniprot/G1KIM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane|||Secreted http://togogenome.org/gene/28377:rgmb ^@ http://purl.uniprot.org/uniprot/G1KLJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:mettl14 ^@ http://purl.uniprot.org/uniprot/G1KP31 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MT-A70-like family.|||Heterodimer; heterodimerizes with mettl3 to form an antiparallel heterodimer that constitutes an active methyltransferase.|||Nucleus|||The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with mettl3, mettl14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. http://togogenome.org/gene/28377:gsc ^@ http://purl.uniprot.org/uniprot/G1KN40 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:slc30a5 ^@ http://purl.uniprot.org/uniprot/G1KSJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Functions as a zinc transporter.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/28377:msrb2 ^@ http://purl.uniprot.org/uniprot/R4GCW9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/28377:cd74 ^@ http://purl.uniprot.org/uniprot/G1KQJ0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:abcb9 ^@ http://purl.uniprot.org/uniprot/H9GMN0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:LOC100558140 ^@ http://purl.uniprot.org/uniprot/G1KJG0 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/28377:b4galnt2 ^@ http://purl.uniprot.org/uniprot/G1KF32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family.|||Membrane http://togogenome.org/gene/28377:itgb5 ^@ http://purl.uniprot.org/uniprot/G1KJY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:nts ^@ http://purl.uniprot.org/uniprot/G1KKX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurotensin family.|||Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/28377:c3 ^@ http://purl.uniprot.org/uniprot/G1KTS0 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/28377:fam13a ^@ http://purl.uniprot.org/uniprot/A0A803TEU0|||http://purl.uniprot.org/uniprot/A0A803TGX2|||http://purl.uniprot.org/uniprot/G1KNK6 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/28377:foxg1 ^@ http://purl.uniprot.org/uniprot/G1KS18 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:tmem177 ^@ http://purl.uniprot.org/uniprot/G1KCB2 ^@ Function|||Similarity ^@ Belongs to the TMEM177 family.|||Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein. http://togogenome.org/gene/28377:tmco3 ^@ http://purl.uniprot.org/uniprot/A0A803TFY0|||http://purl.uniprot.org/uniprot/G1K8H0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:LOC100557468 ^@ http://purl.uniprot.org/uniprot/A0A803T3I3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:rftn1 ^@ http://purl.uniprot.org/uniprot/G1KH26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:tcn1 ^@ http://purl.uniprot.org/uniprot/G1KJJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/28377:prkx ^@ http://purl.uniprot.org/uniprot/G1KEK9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/28377:itgb4 ^@ http://purl.uniprot.org/uniprot/A0A803U0K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:lyrm7 ^@ http://purl.uniprot.org/uniprot/G1K9E1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.|||Belongs to the complex I LYR family.|||Interacts with UQCRFS1.|||Mitochondrion matrix http://togogenome.org/gene/28377:gucy1a2 ^@ http://purl.uniprot.org/uniprot/G1KKU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/28377:cdc42ep3 ^@ http://purl.uniprot.org/uniprot/G1KHW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/28377:gfod1 ^@ http://purl.uniprot.org/uniprot/A0A803TH18 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/28377:LOC100563080 ^@ http://purl.uniprot.org/uniprot/G1KR33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:elavl2 ^@ http://purl.uniprot.org/uniprot/A0A803SPV3|||http://purl.uniprot.org/uniprot/G1KU25 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/28377:LOC103277727 ^@ http://purl.uniprot.org/uniprot/G1KR96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIP family.|||adherens junction|||centriolar satellite http://togogenome.org/gene/28377:fshb ^@ http://purl.uniprot.org/uniprot/G1KA28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/28377:zadh2 ^@ http://purl.uniprot.org/uniprot/G1KDW9 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/28377:rab3d ^@ http://purl.uniprot.org/uniprot/G1KT46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/28377:LOC100552468 ^@ http://purl.uniprot.org/uniprot/L7N044 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:pigx ^@ http://purl.uniprot.org/uniprot/A0A803THV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGX family.|||Endoplasmic reticulum membrane|||Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. http://togogenome.org/gene/28377:LOC100560578 ^@ http://purl.uniprot.org/uniprot/G1KDV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane http://togogenome.org/gene/28377:LOC100568171 ^@ http://purl.uniprot.org/uniprot/G1KJK1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/28377:trim16 ^@ http://purl.uniprot.org/uniprot/G1KU47 ^@ Function|||Similarity ^@ Belongs to the ohanin/vespryn family.|||Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal. http://togogenome.org/gene/28377:grem2 ^@ http://purl.uniprot.org/uniprot/A0A803SVP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/28377:myh7b ^@ http://purl.uniprot.org/uniprot/L7MZS4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/28377:ftcd ^@ http://purl.uniprot.org/uniprot/G1KD94 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds and promotes bundling of vimentin filaments originating from the Golgi.|||Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.|||Golgi apparatus|||Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.|||In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.|||In the N-terminal section; belongs to the formiminotransferase family.|||centriole http://togogenome.org/gene/28377:cdk5rap3 ^@ http://purl.uniprot.org/uniprot/G1KFP2 ^@ Similarity ^@ Belongs to the CDK5RAP3 family. http://togogenome.org/gene/28377:ethe1 ^@ http://purl.uniprot.org/uniprot/H9G8U4 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/28377:tmbim6 ^@ http://purl.uniprot.org/uniprot/G1KZB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/28377:pitpnm1 ^@ http://purl.uniprot.org/uniprot/G1KJQ7 ^@ Similarity ^@ Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. http://togogenome.org/gene/28377:tmtc4 ^@ http://purl.uniprot.org/uniprot/G1KBZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/28377:capn2 ^@ http://purl.uniprot.org/uniprot/A0A803TYH8|||http://purl.uniprot.org/uniprot/G1KC29 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/28377:tpd52l2 ^@ http://purl.uniprot.org/uniprot/A0A803T3S1|||http://purl.uniprot.org/uniprot/G1KC50 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/28377:mgme1 ^@ http://purl.uniprot.org/uniprot/G1KPL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGME1 family.|||Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair.|||Mitochondrion http://togogenome.org/gene/28377:copb2 ^@ http://purl.uniprot.org/uniprot/G1KBX2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat COPB2 family.|||COPI-coated vesicle membrane|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.|||This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner. http://togogenome.org/gene/28377:dclre1b ^@ http://purl.uniprot.org/uniprot/A0A803TBP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/28377:ngb ^@ http://purl.uniprot.org/uniprot/A0A803TPD9 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/28377:s1pr1 ^@ http://purl.uniprot.org/uniprot/A0A803T1B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:sstr3 ^@ http://purl.uniprot.org/uniprot/G1KS46 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:crhbp ^@ http://purl.uniprot.org/uniprot/G1KH88 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRF-binding protein family.|||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|||Secreted http://togogenome.org/gene/28377:bre ^@ http://purl.uniprot.org/uniprot/G1KJ43 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BABAM2 family.|||Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.|||Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.|||Cytoplasm|||May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.|||Nucleus http://togogenome.org/gene/28377:snx10 ^@ http://purl.uniprot.org/uniprot/A0A803T2K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/28377:sec23b ^@ http://purl.uniprot.org/uniprot/G1KGF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/28377:LOC100556702 ^@ http://purl.uniprot.org/uniprot/G1KEU6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:pomgnt2 ^@ http://purl.uniprot.org/uniprot/G1KBI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 61 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:LOC100561108 ^@ http://purl.uniprot.org/uniprot/G1KM68 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:birc7 ^@ http://purl.uniprot.org/uniprot/A0A803SWD0 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/28377:c3h11orf54 ^@ http://purl.uniprot.org/uniprot/G1KQ09 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.|||Monomer.|||Nucleus http://togogenome.org/gene/28377:nsun4 ^@ http://purl.uniprot.org/uniprot/A0A803SL53 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/28377:LOC100556885 ^@ http://purl.uniprot.org/uniprot/G1KPP1 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/28377:LOC100560836 ^@ http://purl.uniprot.org/uniprot/A0A803TNC6 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/28377:tmem106b ^@ http://purl.uniprot.org/uniprot/A0A803SM18 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/28377:mgat1 ^@ http://purl.uniprot.org/uniprot/G1KL90 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.|||Membrane|||The cofactor is mostly bound to the substrate. http://togogenome.org/gene/28377:LOC100564182 ^@ http://purl.uniprot.org/uniprot/G1KUI4 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. FIG1 subfamily. http://togogenome.org/gene/28377:mmaa ^@ http://purl.uniprot.org/uniprot/G1KC15 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/28377:gtpbp4 ^@ http://purl.uniprot.org/uniprot/G1KBJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/28377:eif4e3 ^@ http://purl.uniprot.org/uniprot/A0A803T2K3 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/28377:LOC100567188 ^@ http://purl.uniprot.org/uniprot/R4GD93 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/28377:LOC100563524 ^@ http://purl.uniprot.org/uniprot/R4G9W1 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/28377:urod ^@ http://purl.uniprot.org/uniprot/G1KQY1 ^@ Similarity|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Homodimer. http://togogenome.org/gene/28377:acer2 ^@ http://purl.uniprot.org/uniprot/G1KU81 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:LOC100562477 ^@ http://purl.uniprot.org/uniprot/G1KNG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/28377:hpse2 ^@ http://purl.uniprot.org/uniprot/G1KBY9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/28377:pspc1 ^@ http://purl.uniprot.org/uniprot/G1KAB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PSPC family.|||Cytoplasm|||Nucleus matrix|||Nucleus speckle|||nucleolus http://togogenome.org/gene/28377:tor1aip2 ^@ http://purl.uniprot.org/uniprot/A0A803T9R0|||http://purl.uniprot.org/uniprot/G1K935 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOR1AIP family.|||Membrane http://togogenome.org/gene/28377:dmrt2 ^@ http://purl.uniprot.org/uniprot/G1KAN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/28377:aga ^@ http://purl.uniprot.org/uniprot/G1KEX1 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/28377:pnpla4 ^@ http://purl.uniprot.org/uniprot/G1K8H3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:actr5 ^@ http://purl.uniprot.org/uniprot/G1KPJ5 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/28377:brinp2 ^@ http://purl.uniprot.org/uniprot/G1KPX2 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/28377:sptlc3 ^@ http://purl.uniprot.org/uniprot/G1KZA9 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/28377:chga ^@ http://purl.uniprot.org/uniprot/G1KI85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/28377:LOC103278032 ^@ http://purl.uniprot.org/uniprot/G1KLC8 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/28377:ago2 ^@ http://purl.uniprot.org/uniprot/G1K8D5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argonaute family. Ago subfamily.|||Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of dicer1, ago2 and tarbp2. Note that the trimeric RLC/miRLC is also referred to as RISC.|||P-body|||Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by ago2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur.|||The Piwi domain may perform RNA cleavage by a mechanism similar to that of RNase H. However, while RNase H utilizes a triad of Asp-Asp-Glu (DDE) for metal ion coordination, this protein appears to utilize a triad of Asp-Asp-His (DDH). http://togogenome.org/gene/28377:gucy1a3 ^@ http://purl.uniprot.org/uniprot/G1KTE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/28377:slc10a3 ^@ http://purl.uniprot.org/uniprot/G1KY98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/28377:syt1 ^@ http://purl.uniprot.org/uniprot/G1KPD2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||synaptic vesicle membrane http://togogenome.org/gene/28377:trim67 ^@ http://purl.uniprot.org/uniprot/G1KAM1 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/28377:mpp2 ^@ http://purl.uniprot.org/uniprot/G1KDF5 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/28377:clk4 ^@ http://purl.uniprot.org/uniprot/A0A803SWY5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/28377:LOC100567570 ^@ http://purl.uniprot.org/uniprot/A0A803T9I8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:kif23 ^@ http://purl.uniprot.org/uniprot/A0A803SKR8|||http://purl.uniprot.org/uniprot/A0A803TXD2|||http://purl.uniprot.org/uniprot/G1KA35 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/28377:hibch ^@ http://purl.uniprot.org/uniprot/G1K8R3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.|||Mitochondrion http://togogenome.org/gene/28377:uchl1 ^@ http://purl.uniprot.org/uniprot/G1KLS5 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/28377:gda ^@ http://purl.uniprot.org/uniprot/G1KMU1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. http://togogenome.org/gene/28377:shroom3 ^@ http://purl.uniprot.org/uniprot/A0A803TWN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/28377:gpr183 ^@ http://purl.uniprot.org/uniprot/G1KUP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:pitpnm2 ^@ http://purl.uniprot.org/uniprot/H9GMK4 ^@ Similarity ^@ Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. http://togogenome.org/gene/28377:pgm3 ^@ http://purl.uniprot.org/uniprot/G1KTQ4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. http://togogenome.org/gene/28377:cnih3 ^@ http://purl.uniprot.org/uniprot/A0A803TVG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/28377:arv1 ^@ http://purl.uniprot.org/uniprot/G1KAH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane http://togogenome.org/gene/28377:hddc2 ^@ http://purl.uniprot.org/uniprot/G1K9V4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HDDC2 family.|||Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).|||Homodimer. http://togogenome.org/gene/28377:tma16 ^@ http://purl.uniprot.org/uniprot/G1KDM4 ^@ Function|||Similarity|||Subunit ^@ Associates with pre-60S ribosomal particles.|||Belongs to the TMA16 family.|||Involved in the biogenesis of the 60S ribosomal subunit in the nucleus. http://togogenome.org/gene/28377:LOC100561640 ^@ http://purl.uniprot.org/uniprot/G1KMJ6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:acss1 ^@ http://purl.uniprot.org/uniprot/G1KP87 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/28377:cd36 ^@ http://purl.uniprot.org/uniprot/G1KRS5 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/28377:atp6ap2 ^@ http://purl.uniprot.org/uniprot/G1KPW9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Lysosome membrane|||Membrane|||autophagosome membrane|||clathrin-coated vesicle membrane|||dendritic spine membrane|||synaptic vesicle membrane http://togogenome.org/gene/28377:kctd20 ^@ http://purl.uniprot.org/uniprot/G1KST3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/28377:prph2 ^@ http://purl.uniprot.org/uniprot/G1K8N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/28377:zeb1 ^@ http://purl.uniprot.org/uniprot/A0A803U028 ^@ Similarity ^@ Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. http://togogenome.org/gene/28377:cp ^@ http://purl.uniprot.org/uniprot/G1KGN3 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/28377:LOC100552374 ^@ http://purl.uniprot.org/uniprot/G1KBP7 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/28377:LOC100567765 ^@ http://purl.uniprot.org/uniprot/G1KTI9 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/28377:chd1 ^@ http://purl.uniprot.org/uniprot/G1KLI0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:LOC100554014 ^@ http://purl.uniprot.org/uniprot/G1K9A8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:atg9a ^@ http://purl.uniprot.org/uniprot/G1KNA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG9 family.|||Membrane|||Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/28377:asip ^@ http://purl.uniprot.org/uniprot/A0A803SW56|||http://purl.uniprot.org/uniprot/A0A803TJ35 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/28377:wdpcp ^@ http://purl.uniprot.org/uniprot/G1KEQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat fritz family.|||Cell membrane|||Membrane|||cilium axoneme http://togogenome.org/gene/28377:xylt2 ^@ http://purl.uniprot.org/uniprot/G1KDY5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 14 family. XylT subfamily.|||Golgi apparatus membrane|||Membrane|||Monomer. http://togogenome.org/gene/28377:crmp1 ^@ http://purl.uniprot.org/uniprot/G1KQV0 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/28377:neto2 ^@ http://purl.uniprot.org/uniprot/A0A803SWC0|||http://purl.uniprot.org/uniprot/H9GK82 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:cpxm2 ^@ http://purl.uniprot.org/uniprot/G1KU22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Secreted http://togogenome.org/gene/28377:atg4b ^@ http://purl.uniprot.org/uniprot/G1K8U0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/28377:plpp4 ^@ http://purl.uniprot.org/uniprot/R4GC42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/28377:gata1 ^@ http://purl.uniprot.org/uniprot/G1KH54 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:LOC100557289 ^@ http://purl.uniprot.org/uniprot/A0A803SVQ5|||http://purl.uniprot.org/uniprot/A0A803THF8 ^@ Similarity ^@ Belongs to the CD99 family. http://togogenome.org/gene/28377:LOC100561045 ^@ http://purl.uniprot.org/uniprot/G1KKF9 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/28377:bmpr1b ^@ http://purl.uniprot.org/uniprot/G1KP73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane|||Secreted http://togogenome.org/gene/28377:phactr3 ^@ http://purl.uniprot.org/uniprot/A0A803SVQ9|||http://purl.uniprot.org/uniprot/G1KC59 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/28377:nfe2l1 ^@ http://purl.uniprot.org/uniprot/G1KFJ8 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/28377:nfya ^@ http://purl.uniprot.org/uniprot/A0A803SVQ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus http://togogenome.org/gene/28377:tgfb1 ^@ http://purl.uniprot.org/uniprot/H9GR44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.|||extracellular matrix http://togogenome.org/gene/28377:tns4 ^@ http://purl.uniprot.org/uniprot/G1KS71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/28377:des ^@ http://purl.uniprot.org/uniprot/G1KPB3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:foxred2 ^@ http://purl.uniprot.org/uniprot/G1KSH7 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. FIG1 subfamily. http://togogenome.org/gene/28377:parp11 ^@ http://purl.uniprot.org/uniprot/A0A803T3P8 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/28377:LOC103278482 ^@ http://purl.uniprot.org/uniprot/A0A803T8M9|||http://purl.uniprot.org/uniprot/A0A803TAS9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:kcns2 ^@ http://purl.uniprot.org/uniprot/G1KS67 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:shcbp1 ^@ http://purl.uniprot.org/uniprot/A0A803TRL7|||http://purl.uniprot.org/uniprot/H9GJQ9 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/28377:il17d ^@ http://purl.uniprot.org/uniprot/A0A803T2E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/28377:rpl8 ^@ http://purl.uniprot.org/uniprot/G1KUJ6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/28377:pik3c2a ^@ http://purl.uniprot.org/uniprot/G1K875 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/28377:med25 ^@ http://purl.uniprot.org/uniprot/A0A803SYN4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 25 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/28377:fam3d ^@ http://purl.uniprot.org/uniprot/G1KL39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/28377:prcp ^@ http://purl.uniprot.org/uniprot/G1K911 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/28377:gnpat ^@ http://purl.uniprot.org/uniprot/G1KAU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Peroxisome membrane http://togogenome.org/gene/28377:tsn ^@ http://purl.uniprot.org/uniprot/A0A803TAL2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the translin family.|||DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.|||Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.|||Nucleus|||Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring. http://togogenome.org/gene/28377:fitm2 ^@ http://purl.uniprot.org/uniprot/G1KT26 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:tjp2 ^@ http://purl.uniprot.org/uniprot/A0A803TTD2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/28377:pelo ^@ http://purl.uniprot.org/uniprot/G1KCR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.|||Cytoplasm http://togogenome.org/gene/28377:cenpn ^@ http://purl.uniprot.org/uniprot/H9GEG8 ^@ Similarity ^@ Belongs to the CENP-N/CHL4 family. http://togogenome.org/gene/28377:tmem136 ^@ http://purl.uniprot.org/uniprot/H9G7E2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:mfsd5 ^@ http://purl.uniprot.org/uniprot/G1KFP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Cell membrane|||Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.|||Membrane http://togogenome.org/gene/28377:plk3 ^@ http://purl.uniprot.org/uniprot/G1KRC9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/28377:phka2 ^@ http://purl.uniprot.org/uniprot/A0A803TF64|||http://purl.uniprot.org/uniprot/G1KLN6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. http://togogenome.org/gene/28377:lca5 ^@ http://purl.uniprot.org/uniprot/G1KCX4 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/28377:LOC100567580 ^@ http://purl.uniprot.org/uniprot/A0A803T367 ^@ Function|||Similarity ^@ Belongs to the PET191 family.|||Involved in an early step of the mitochondrial complex IV assembly process. http://togogenome.org/gene/28377:sgcg ^@ http://purl.uniprot.org/uniprot/G1KBF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/28377:LOC100565965 ^@ http://purl.uniprot.org/uniprot/G1KBT2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. http://togogenome.org/gene/28377:pqlc1 ^@ http://purl.uniprot.org/uniprot/A0A803T3E0|||http://purl.uniprot.org/uniprot/A0A803TNQ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:mstn ^@ http://purl.uniprot.org/uniprot/G1KCN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Secreted http://togogenome.org/gene/28377:vps37a ^@ http://purl.uniprot.org/uniprot/G1KF83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/28377:sgce ^@ http://purl.uniprot.org/uniprot/A0A803SMH8 ^@ Function|||Similarity ^@ Belongs to the sarcoglycan alpha/epsilon family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. http://togogenome.org/gene/28377:zc2hc1c ^@ http://purl.uniprot.org/uniprot/G1KT67 ^@ Similarity ^@ Belongs to the ZC2HC1 family. http://togogenome.org/gene/28377:ahcyl1 ^@ http://purl.uniprot.org/uniprot/G1KM02 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/28377:tmcc2 ^@ http://purl.uniprot.org/uniprot/A0A803TZB8|||http://purl.uniprot.org/uniprot/G1KPX0 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/28377:gbe1 ^@ http://purl.uniprot.org/uniprot/A0A803TSP8|||http://purl.uniprot.org/uniprot/G1KAH1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. http://togogenome.org/gene/28377:ska3 ^@ http://purl.uniprot.org/uniprot/A0A803TMK8|||http://purl.uniprot.org/uniprot/A0A803TXM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SKA3 family.|||kinetochore|||spindle http://togogenome.org/gene/28377:ppp2r2c ^@ http://purl.uniprot.org/uniprot/A0A803SWT2|||http://purl.uniprot.org/uniprot/A0A803TXJ3 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/28377:rap2b ^@ http://purl.uniprot.org/uniprot/G1KL05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/28377:yipf7 ^@ http://purl.uniprot.org/uniprot/G1KG47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/28377:ugcg ^@ http://purl.uniprot.org/uniprot/G1KTQ7 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/28377:uros ^@ http://purl.uniprot.org/uniprot/G1K8Y2 ^@ Similarity ^@ Belongs to the uroporphyrinogen-III synthase family. http://togogenome.org/gene/28377:sigirr ^@ http://purl.uniprot.org/uniprot/G1KNW6 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/28377:gtf2h5 ^@ http://purl.uniprot.org/uniprot/A0A803T9V2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/28377:ift43 ^@ http://purl.uniprot.org/uniprot/G1KTG5 ^@ Similarity ^@ Belongs to the IFT43 family. http://togogenome.org/gene/28377:glrx ^@ http://purl.uniprot.org/uniprot/G1KMZ3 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. http://togogenome.org/gene/28377:mmrn1 ^@ http://purl.uniprot.org/uniprot/G1KNP1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:idh1 ^@ http://purl.uniprot.org/uniprot/G1KJG1 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/28377:pus7l ^@ http://purl.uniprot.org/uniprot/G1KBG1 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/28377:cldn10 ^@ http://purl.uniprot.org/uniprot/G1KA53 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/28377:lrrc8b ^@ http://purl.uniprot.org/uniprot/G1KZ23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:ptpn4 ^@ http://purl.uniprot.org/uniprot/G1KUQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/28377:mpp3 ^@ http://purl.uniprot.org/uniprot/G1KD43 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/28377:p2ry13 ^@ http://purl.uniprot.org/uniprot/G1KUN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:dicer1 ^@ http://purl.uniprot.org/uniprot/G1KND9 ^@ Function|||Similarity ^@ Belongs to the helicase family. Dicer subfamily.|||Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. http://togogenome.org/gene/28377:ltv1 ^@ http://purl.uniprot.org/uniprot/A0A803TN78 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/28377:inip ^@ http://purl.uniprot.org/uniprot/A0A803TA35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SOSS-C family.|||Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).|||Component of the SOSS complex.|||Nucleus http://togogenome.org/gene/28377:tm9sf2 ^@ http://purl.uniprot.org/uniprot/G1KIE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/28377:cap2 ^@ http://purl.uniprot.org/uniprot/G1KCH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAP family.|||Cell membrane http://togogenome.org/gene/28377:mmachc ^@ http://purl.uniprot.org/uniprot/G1KQS9 ^@ Similarity ^@ Belongs to the MMACHC family. http://togogenome.org/gene/28377:trpc6 ^@ http://purl.uniprot.org/uniprot/G1KMX6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:syngr1 ^@ http://purl.uniprot.org/uniprot/A0A803TSR4|||http://purl.uniprot.org/uniprot/G1KXB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/28377:zeb2 ^@ http://purl.uniprot.org/uniprot/G1KZE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.|||Nucleus http://togogenome.org/gene/28377:LOC100566309 ^@ http://purl.uniprot.org/uniprot/A0A803SQI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/28377:LOC100552382 ^@ http://purl.uniprot.org/uniprot/G1KPD5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/28377:ptges3 ^@ http://purl.uniprot.org/uniprot/G1KIJ3 ^@ Similarity ^@ Belongs to the p23/wos2 family. http://togogenome.org/gene/28377:gli2 ^@ http://purl.uniprot.org/uniprot/G1KCN6 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/28377:tlr5 ^@ http://purl.uniprot.org/uniprot/G1KAR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/28377:panx2 ^@ http://purl.uniprot.org/uniprot/G1KAJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/28377:grhl1 ^@ http://purl.uniprot.org/uniprot/A0A803TKT8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:c3hxorf23 ^@ http://purl.uniprot.org/uniprot/G1KMH8 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/28377:snf8 ^@ http://purl.uniprot.org/uniprot/A0A803THN7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SNF8 family.|||Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II). http://togogenome.org/gene/28377:LOC100552057 ^@ http://purl.uniprot.org/uniprot/G1KDC5 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/28377:csrnp1 ^@ http://purl.uniprot.org/uniprot/G1KJA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/28377:slc39a5 ^@ http://purl.uniprot.org/uniprot/G1KVI4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:tmem165 ^@ http://purl.uniprot.org/uniprot/G1KJ29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GDT1 family.|||Membrane http://togogenome.org/gene/28377:ndrg1 ^@ http://purl.uniprot.org/uniprot/G1KLK6 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/28377:slc9a9 ^@ http://purl.uniprot.org/uniprot/G1KJ91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/28377:adhfe1 ^@ http://purl.uniprot.org/uniprot/G1KSW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.|||Mitochondrion http://togogenome.org/gene/28377:ppp1r21 ^@ http://purl.uniprot.org/uniprot/G1KPS2 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/28377:ldah ^@ http://purl.uniprot.org/uniprot/G1KKE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. LDAH family.|||Lipid droplet http://togogenome.org/gene/28377:tsg101 ^@ http://purl.uniprot.org/uniprot/G1K889 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily. http://togogenome.org/gene/28377:tmem87a ^@ http://purl.uniprot.org/uniprot/A0A803T2L9|||http://purl.uniprot.org/uniprot/G1KQY9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:caskin2 ^@ http://purl.uniprot.org/uniprot/A0A803TDE5|||http://purl.uniprot.org/uniprot/G1KFM2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/28377:fn3krp ^@ http://purl.uniprot.org/uniprot/G1KTU8 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/28377:lmln ^@ http://purl.uniprot.org/uniprot/G1KJC1 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M8 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/28377:LOC100558133 ^@ http://purl.uniprot.org/uniprot/G1KK72 ^@ Function|||Similarity ^@ Belongs to the ohanin/vespryn family.|||Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal. http://togogenome.org/gene/28377:ltbp1 ^@ http://purl.uniprot.org/uniprot/G1KIP0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/28377:hspa4 ^@ http://purl.uniprot.org/uniprot/G1KNK5 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/28377:LOC100567003 ^@ http://purl.uniprot.org/uniprot/G1KR32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:rwdd3 ^@ http://purl.uniprot.org/uniprot/G1KD60 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/28377:hdac3 ^@ http://purl.uniprot.org/uniprot/G1KLP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/28377:kdr ^@ http://purl.uniprot.org/uniprot/G1KJF5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:nlgn4x ^@ http://purl.uniprot.org/uniprot/D2X2I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:plk4 ^@ http://purl.uniprot.org/uniprot/G1KLA0 ^@ Subcellular Location Annotation ^@ centriole http://togogenome.org/gene/28377:hoxb7 ^@ http://purl.uniprot.org/uniprot/A0A803TRP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/28377:LOC100559577 ^@ http://purl.uniprot.org/uniprot/A0A803TH58 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/28377:hectd1 ^@ http://purl.uniprot.org/uniprot/G1KQQ3 ^@ Function|||Similarity ^@ Belongs to the UPL family. K-HECT subfamily.|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. http://togogenome.org/gene/28377:yipf2 ^@ http://purl.uniprot.org/uniprot/G1KQZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Golgi apparatus membrane|||Late endosome membrane|||Membrane|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/28377:epn3 ^@ http://purl.uniprot.org/uniprot/G1KDN4 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/28377:efnb2 ^@ http://purl.uniprot.org/uniprot/A0A803TTX9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:rxfp1 ^@ http://purl.uniprot.org/uniprot/G1KST2 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:tspan1 ^@ http://purl.uniprot.org/uniprot/R4G9D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/28377:ndufaf3 ^@ http://purl.uniprot.org/uniprot/G1KMA7 ^@ Function|||Subcellular Location Annotation ^@ Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Membrane|||Mitochondrion inner membrane|||Nucleus http://togogenome.org/gene/28377:shq1 ^@ http://purl.uniprot.org/uniprot/G1KQC4 ^@ Similarity ^@ Belongs to the SHQ1 family. http://togogenome.org/gene/28377:LOC100567906 ^@ http://purl.uniprot.org/uniprot/R4GBC5 ^@ Function|||Subcellular Location Annotation ^@ Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.|||Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.|||Secreted http://togogenome.org/gene/28377:orc5 ^@ http://purl.uniprot.org/uniprot/G1KFY6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:pex16 ^@ http://purl.uniprot.org/uniprot/G1KQE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-16 family.|||Peroxisome membrane http://togogenome.org/gene/28377:ppp1ca ^@ http://purl.uniprot.org/uniprot/G1KHF3 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-1 subfamily. http://togogenome.org/gene/28377:nploc4 ^@ http://purl.uniprot.org/uniprot/G1KQR1 ^@ Similarity ^@ Belongs to the NPL4 family. http://togogenome.org/gene/28377:LOC100567335 ^@ http://purl.uniprot.org/uniprot/G1KUL5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/28377:rsad1 ^@ http://purl.uniprot.org/uniprot/A0A803SSC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Mitochondrion http://togogenome.org/gene/28377:slc30a8 ^@ http://purl.uniprot.org/uniprot/G1KKM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/28377:gaa ^@ http://purl.uniprot.org/uniprot/G1KRW0 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 31 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:bckdha ^@ http://purl.uniprot.org/uniprot/H9G813 ^@ Function|||Similarity ^@ Belongs to the BCKDHA family.|||The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/28377:recql5 ^@ http://purl.uniprot.org/uniprot/G1KFY1 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/28377:clgn ^@ http://purl.uniprot.org/uniprot/G1KAL5 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/28377:tex10 ^@ http://purl.uniprot.org/uniprot/A0A803TD06 ^@ Similarity ^@ Belongs to the IPI1/TEX10 family. http://togogenome.org/gene/28377:suv39h1 ^@ http://purl.uniprot.org/uniprot/G1KF95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Nucleus|||centromere http://togogenome.org/gene/28377:LOC100559827 ^@ http://purl.uniprot.org/uniprot/G1KIC7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/28377:golm1 ^@ http://purl.uniprot.org/uniprot/G1K8H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/28377:LOC100564389 ^@ http://purl.uniprot.org/uniprot/G1KMA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/28377:fgd5 ^@ http://purl.uniprot.org/uniprot/G1KLT5 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/28377:LOC100556372 ^@ http://purl.uniprot.org/uniprot/G1KRJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion. http://togogenome.org/gene/28377:dusp10 ^@ http://purl.uniprot.org/uniprot/G1KA87 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/28377:LOC100565099 ^@ http://purl.uniprot.org/uniprot/G1KL27 ^@ Function|||Similarity ^@ Belongs to the ohanin/vespryn family.|||Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal. http://togogenome.org/gene/28377:cryl1 ^@ http://purl.uniprot.org/uniprot/G1KAH7 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/28377:LOC103278680 ^@ http://purl.uniprot.org/uniprot/A0A803SXS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/28377:ccdc181 ^@ http://purl.uniprot.org/uniprot/G1KK94 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC181 family.|||Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.|||cytoskeleton http://togogenome.org/gene/28377:LOC100561418 ^@ http://purl.uniprot.org/uniprot/G1K8Z0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIc family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/28377:p2rx4 ^@ http://purl.uniprot.org/uniprot/H9GN73 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/28377:LOC100556182 ^@ http://purl.uniprot.org/uniprot/G1KUN0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/28377:LOC103278044 ^@ http://purl.uniprot.org/uniprot/A0A803TFD0 ^@ Function|||Similarity ^@ Belongs to the ohanin/vespryn family.|||Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal. http://togogenome.org/gene/28377:stk3 ^@ http://purl.uniprot.org/uniprot/G1KSA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Nucleus http://togogenome.org/gene/28377:emc7 ^@ http://purl.uniprot.org/uniprot/G1KR03 ^@ Similarity|||Subunit ^@ Belongs to the EMC7 family.|||Component of the ER membrane protein complex (EMC). http://togogenome.org/gene/28377:kiaa1324l ^@ http://purl.uniprot.org/uniprot/G1KSS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELAPOR family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:oxr1 ^@ http://purl.uniprot.org/uniprot/A0A803SQG2|||http://purl.uniprot.org/uniprot/G1KJJ0 ^@ Similarity ^@ Belongs to the OXR1 family. http://togogenome.org/gene/28377:LOC100565295 ^@ http://purl.uniprot.org/uniprot/G1KLA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Belongs to the ohanin/vespryn family.|||Membrane|||Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal. http://togogenome.org/gene/28377:rnf8 ^@ http://purl.uniprot.org/uniprot/G1K9T9 ^@ Similarity ^@ Belongs to the CHFR family.|||Belongs to the RNF8 family. http://togogenome.org/gene/28377:chst3 ^@ http://purl.uniprot.org/uniprot/G1KUD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/28377:dfna5 ^@ http://purl.uniprot.org/uniprot/G1KNI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:gys2 ^@ http://purl.uniprot.org/uniprot/G1KTH7 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/28377:lyrm2 ^@ http://purl.uniprot.org/uniprot/G1KPV5 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/28377:cd151 ^@ http://purl.uniprot.org/uniprot/G1KR65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/28377:olfml2b ^@ http://purl.uniprot.org/uniprot/G1K9A1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:slc35b4 ^@ http://purl.uniprot.org/uniprot/A0A803TED3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/28377:ctdp1 ^@ http://purl.uniprot.org/uniprot/G1KVK5 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||This promotes the activity of RNA polymerase II. http://togogenome.org/gene/28377:entpd5 ^@ http://purl.uniprot.org/uniprot/G1KSD8 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/28377:ruvbl2 ^@ http://purl.uniprot.org/uniprot/G1KMP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. http://togogenome.org/gene/28377:plcb4 ^@ http://purl.uniprot.org/uniprot/G1KAY9 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/28377:ppp2r2d ^@ http://purl.uniprot.org/uniprot/G1KHE3 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/28377:lpin2 ^@ http://purl.uniprot.org/uniprot/A0A803T0N6 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/28377:zfpm2 ^@ http://purl.uniprot.org/uniprot/A0A803TT44 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:hoxb1 ^@ http://purl.uniprot.org/uniprot/A0A803TYE2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:ric8a ^@ http://purl.uniprot.org/uniprot/G1KU21 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/28377:LOC100551724 ^@ http://purl.uniprot.org/uniprot/A0A803TRT8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.|||Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. http://togogenome.org/gene/28377:khdrbs2 ^@ http://purl.uniprot.org/uniprot/G1KFP6 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/28377:LOC100562282 ^@ http://purl.uniprot.org/uniprot/R4GAL0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:snx9 ^@ http://purl.uniprot.org/uniprot/A0A803ST54|||http://purl.uniprot.org/uniprot/G1KDL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/28377:sqle ^@ http://purl.uniprot.org/uniprot/G1KJU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the flavin monoamine oxidase family. FIG1 subfamily.|||Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane http://togogenome.org/gene/28377:tbk1 ^@ http://purl.uniprot.org/uniprot/G1KBS7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/28377:LOC100555068 ^@ http://purl.uniprot.org/uniprot/G1KN80 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/28377:dctn4 ^@ http://purl.uniprot.org/uniprot/G1KQ82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunit 4 family.|||cell cortex|||centrosome|||sarcomere|||stress fiber http://togogenome.org/gene/28377:pgm1 ^@ http://purl.uniprot.org/uniprot/G1KHK5 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/28377:LOC100557302 ^@ http://purl.uniprot.org/uniprot/G1KCB5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/28377:ssrp1 ^@ http://purl.uniprot.org/uniprot/A0A803TVB1|||http://purl.uniprot.org/uniprot/G1KGS3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSRP1 family.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Nucleus http://togogenome.org/gene/28377:med14 ^@ http://purl.uniprot.org/uniprot/A0A803TCF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 14 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/28377:ptprn ^@ http://purl.uniprot.org/uniprot/G1KP25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.|||Membrane|||secretory vesicle membrane http://togogenome.org/gene/28377:LOC103278210 ^@ http://purl.uniprot.org/uniprot/G1KSC4 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/28377:mx1 ^@ http://purl.uniprot.org/uniprot/G1KEM8 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/28377:hal ^@ http://purl.uniprot.org/uniprot/G1KPE2 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/28377:zdhhc14 ^@ http://purl.uniprot.org/uniprot/G1KVC6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/28377:ccr10 ^@ http://purl.uniprot.org/uniprot/G1KP85 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:LOC100556842 ^@ http://purl.uniprot.org/uniprot/H9G9C0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/28377:a4gnt ^@ http://purl.uniprot.org/uniprot/G1KIM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 32 family.|||Golgi apparatus membrane http://togogenome.org/gene/28377:ispd ^@ http://purl.uniprot.org/uniprot/G1KMW3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Homodimer.|||cytosol http://togogenome.org/gene/28377:npbwr2 ^@ http://purl.uniprot.org/uniprot/G1KF80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100565091 ^@ http://purl.uniprot.org/uniprot/M1ZMR2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/28377:slc25a19 ^@ http://purl.uniprot.org/uniprot/G1KFF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/28377:sdhaf3 ^@ http://purl.uniprot.org/uniprot/A0A803TFZ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I LYR family. SDHAF3 subfamily.|||Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. http://togogenome.org/gene/28377:znf326 ^@ http://purl.uniprot.org/uniprot/G1K968 ^@ Similarity ^@ Belongs to the AKAP95 family. http://togogenome.org/gene/28377:mfng ^@ http://purl.uniprot.org/uniprot/G1KRT9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:iars ^@ http://purl.uniprot.org/uniprot/G1KJ05 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/28377:b4galt2 ^@ http://purl.uniprot.org/uniprot/G1KPW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/28377:tmx2 ^@ http://purl.uniprot.org/uniprot/G1KG21 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/28377:LOC100567853 ^@ http://purl.uniprot.org/uniprot/G1KD64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/28377:LOC100554292 ^@ http://purl.uniprot.org/uniprot/G1KLF4 ^@ Similarity ^@ Belongs to the GST superfamily. Mu family. http://togogenome.org/gene/28377:LOC100562879 ^@ http://purl.uniprot.org/uniprot/A0A803TXV5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/28377:LOC100553851 ^@ http://purl.uniprot.org/uniprot/A0A803T7J2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:dusp3 ^@ http://purl.uniprot.org/uniprot/G1KD57 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/28377:LOC100562210 ^@ http://purl.uniprot.org/uniprot/A0A803TMD4 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/28377:dpysl3 ^@ http://purl.uniprot.org/uniprot/A0A803TY90|||http://purl.uniprot.org/uniprot/G1KQA0 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/28377:psmd11 ^@ http://purl.uniprot.org/uniprot/G1KSS2 ^@ Similarity ^@ Belongs to the proteasome subunit S9 family. http://togogenome.org/gene/28377:rab3b ^@ http://purl.uniprot.org/uniprot/A0A803TDU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/28377:LOC100564895 ^@ http://purl.uniprot.org/uniprot/A0A803TJ68 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/28377:cers6 ^@ http://purl.uniprot.org/uniprot/A0A803TT83|||http://purl.uniprot.org/uniprot/G1K9E6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/28377:inpp1 ^@ http://purl.uniprot.org/uniprot/G1KHB7 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/28377:pyroxd2 ^@ http://purl.uniprot.org/uniprot/G1KBU8 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. FIG1 subfamily. http://togogenome.org/gene/28377:mpeg1 ^@ http://purl.uniprot.org/uniprot/G1KFN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MPEG1 family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/28377:tppp ^@ http://purl.uniprot.org/uniprot/G1KIV9 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/28377:stard3nl ^@ http://purl.uniprot.org/uniprot/G1KU92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Membrane http://togogenome.org/gene/28377:l1cam ^@ http://purl.uniprot.org/uniprot/A0A803SND1|||http://purl.uniprot.org/uniprot/A0A803SR05|||http://purl.uniprot.org/uniprot/G1KLK3 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. http://togogenome.org/gene/28377:cdc20b ^@ http://purl.uniprot.org/uniprot/A0A803T7H5|||http://purl.uniprot.org/uniprot/A0A803TR89|||http://purl.uniprot.org/uniprot/G1KR39 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/28377:cmc1 ^@ http://purl.uniprot.org/uniprot/A0A803T2T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/28377:galr2 ^@ http://purl.uniprot.org/uniprot/A0A803U085 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/28377:sulf1 ^@ http://purl.uniprot.org/uniprot/A0A803SL44|||http://purl.uniprot.org/uniprot/G1KQZ3 ^@ Cofactor|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Endoplasmic reticulum|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/28377:tpd52l1 ^@ http://purl.uniprot.org/uniprot/A0A803T152|||http://purl.uniprot.org/uniprot/A0A803TRI6|||http://purl.uniprot.org/uniprot/G1K9U2 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/28377:mtch1 ^@ http://purl.uniprot.org/uniprot/R4GAF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/28377:gclc ^@ http://purl.uniprot.org/uniprot/G1KHV4 ^@ Similarity ^@ Belongs to the glutamate--cysteine ligase type 3 family. http://togogenome.org/gene/28377:mms22l ^@ http://purl.uniprot.org/uniprot/G1KK93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MMS22 family. MMS22L subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/28377:LOC100558470 ^@ http://purl.uniprot.org/uniprot/G1K8B0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:foxp1 ^@ http://purl.uniprot.org/uniprot/G1KPA1|||http://purl.uniprot.org/uniprot/R4GBW0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:kcna2 ^@ http://purl.uniprot.org/uniprot/G1KUR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:ccser1 ^@ http://purl.uniprot.org/uniprot/A0A803SVU2 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/28377:ddx1 ^@ http://purl.uniprot.org/uniprot/G1KL19 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX1 subfamily.|||Cytoplasmic granule|||RNA helicase.|||The helicase domain is involved in the stimulation of RELA transcriptional activity. http://togogenome.org/gene/28377:sec61a1 ^@ http://purl.uniprot.org/uniprot/A0A803T481 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:atp9b ^@ http://purl.uniprot.org/uniprot/A0A803T860|||http://purl.uniprot.org/uniprot/G1K8V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/28377:was ^@ http://purl.uniprot.org/uniprot/G1KF86 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:LOC100556776 ^@ http://purl.uniprot.org/uniprot/L7MZH4 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/28377:aacs ^@ http://purl.uniprot.org/uniprot/H9GLA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Converts acetoacetate to acetoacetyl-CoA in the cytosol.|||cytosol http://togogenome.org/gene/28377:acta1 ^@ http://purl.uniprot.org/uniprot/G1K932 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/28377:slc10a2 ^@ http://purl.uniprot.org/uniprot/G1KB29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/28377:LOC103278849 ^@ http://purl.uniprot.org/uniprot/A0A803SQV0 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZP domain family. ZPC subfamily.|||Cell membrane|||Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.|||Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.|||The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.|||Zona pellucida http://togogenome.org/gene/28377:ndfip2 ^@ http://purl.uniprot.org/uniprot/A0A803TLR5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:gls2 ^@ http://purl.uniprot.org/uniprot/G1KSU1 ^@ Similarity ^@ Belongs to the glutaminase family. http://togogenome.org/gene/28377:maml3 ^@ http://purl.uniprot.org/uniprot/G1KAG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mastermind family.|||Nucleus speckle http://togogenome.org/gene/28377:sugct ^@ http://purl.uniprot.org/uniprot/G1KU60 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/28377:slc12a2 ^@ http://purl.uniprot.org/uniprot/A0A803SSP9|||http://purl.uniprot.org/uniprot/G1KAX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/28377:cldn20 ^@ http://purl.uniprot.org/uniprot/G1KDU8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/28377:agap2 ^@ http://purl.uniprot.org/uniprot/A0A803T124|||http://purl.uniprot.org/uniprot/G1KNR8 ^@ Similarity ^@ Belongs to the centaurin gamma-like family. http://togogenome.org/gene/28377:hspa2 ^@ http://purl.uniprot.org/uniprot/G1KRK2 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/28377:LOC100562999 ^@ http://purl.uniprot.org/uniprot/G1KLM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/28377:LOC103279484 ^@ http://purl.uniprot.org/uniprot/R4G9M9 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/28377:LOC100566300 ^@ http://purl.uniprot.org/uniprot/G1KRE4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:st6galnac2 ^@ http://purl.uniprot.org/uniprot/G1KHS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/28377:cul3 ^@ http://purl.uniprot.org/uniprot/G1KCQ3 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/28377:insig1 ^@ http://purl.uniprot.org/uniprot/G1KKP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/28377:mdga1 ^@ http://purl.uniprot.org/uniprot/A0A803TBQ9|||http://purl.uniprot.org/uniprot/A0A803TJA0|||http://purl.uniprot.org/uniprot/R4GAC6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/28377:crybg3 ^@ http://purl.uniprot.org/uniprot/A0A803T6B7 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/28377:cdc14b ^@ http://purl.uniprot.org/uniprot/A0A803T948|||http://purl.uniprot.org/uniprot/A0A803TA17|||http://purl.uniprot.org/uniprot/A0A803TK81|||http://purl.uniprot.org/uniprot/A0A803U058 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/28377:adgre5 ^@ http://purl.uniprot.org/uniprot/A0A803T6T4|||http://purl.uniprot.org/uniprot/A0A803TKJ7 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:ubac2 ^@ http://purl.uniprot.org/uniprot/A0A803TN19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:rnf7 ^@ http://purl.uniprot.org/uniprot/A0A803T8X5 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/28377:adra2a ^@ http://purl.uniprot.org/uniprot/G1KRQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100561357 ^@ http://purl.uniprot.org/uniprot/G1KP45 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:LOC100564437 ^@ http://purl.uniprot.org/uniprot/G1KEQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/28377:fbxl5 ^@ http://purl.uniprot.org/uniprot/A0A803SM02 ^@ Subcellular Location Annotation ^@ perinuclear region http://togogenome.org/gene/28377:mrpl44 ^@ http://purl.uniprot.org/uniprot/G1KCK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.|||Mitochondrion http://togogenome.org/gene/28377:fam76b ^@ http://purl.uniprot.org/uniprot/R4G9A0 ^@ Similarity ^@ Belongs to the FAM76 family. http://togogenome.org/gene/28377:wnt7b ^@ http://purl.uniprot.org/uniprot/G1KPV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/28377:LOC100564631 ^@ http://purl.uniprot.org/uniprot/A0A803TW74 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/28377:mipep ^@ http://purl.uniprot.org/uniprot/A0A803TVD1|||http://purl.uniprot.org/uniprot/G1KBM1 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/28377:mrps6 ^@ http://purl.uniprot.org/uniprot/A0A803TWF2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family. http://togogenome.org/gene/28377:abi3 ^@ http://purl.uniprot.org/uniprot/G1KF21 ^@ Similarity ^@ Belongs to the ABI family. http://togogenome.org/gene/28377:tmem47 ^@ http://purl.uniprot.org/uniprot/G1KS28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/28377:shkbp1 ^@ http://purl.uniprot.org/uniprot/H9G800 ^@ Similarity ^@ Belongs to the KCTD3 family. http://togogenome.org/gene/28377:bmp2 ^@ http://purl.uniprot.org/uniprot/A0A803SPC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/28377:ddx3x ^@ http://purl.uniprot.org/uniprot/A0A803T483|||http://purl.uniprot.org/uniprot/A0A803TKA3|||http://purl.uniprot.org/uniprot/G1KUJ3 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/28377:ilvbl ^@ http://purl.uniprot.org/uniprot/G1KS36 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/28377:znf830 ^@ http://purl.uniprot.org/uniprot/G1KJC6 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus speckle http://togogenome.org/gene/28377:slc39a6 ^@ http://purl.uniprot.org/uniprot/G1K9Y6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:cnot9 ^@ http://purl.uniprot.org/uniprot/G1KAW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT9 family.|||P-body http://togogenome.org/gene/28377:vps25 ^@ http://purl.uniprot.org/uniprot/A0A803TFN7 ^@ Similarity ^@ Belongs to the VPS25 family. http://togogenome.org/gene/28377:tmc8 ^@ http://purl.uniprot.org/uniprot/G1KT29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/28377:LOC103278362 ^@ http://purl.uniprot.org/uniprot/G1KE10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:foxm1 ^@ http://purl.uniprot.org/uniprot/A0A803T1D9|||http://purl.uniprot.org/uniprot/A0A803TP83 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:becn1 ^@ http://purl.uniprot.org/uniprot/G1KP93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beclin family.|||Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Mitochondrion membrane|||autophagosome|||trans-Golgi network membrane http://togogenome.org/gene/28377:rapgef6 ^@ http://purl.uniprot.org/uniprot/A0A803T248|||http://purl.uniprot.org/uniprot/A0A803TMM0|||http://purl.uniprot.org/uniprot/G1KLW8 ^@ Similarity ^@ Belongs to the RAPGEF2 family. http://togogenome.org/gene/28377:ss18 ^@ http://purl.uniprot.org/uniprot/A0A803TEV3|||http://purl.uniprot.org/uniprot/G1KA52 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/28377:khsrp ^@ http://purl.uniprot.org/uniprot/G1KR51 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:vwc2l ^@ http://purl.uniprot.org/uniprot/A0A803TY67|||http://purl.uniprot.org/uniprot/G1KR36 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/28377:LOC100559872 ^@ http://purl.uniprot.org/uniprot/G1KGC9 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/28377:nt5dc2 ^@ http://purl.uniprot.org/uniprot/G1KG58 ^@ Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family. http://togogenome.org/gene/28377:rpia ^@ http://purl.uniprot.org/uniprot/A0A803T954 ^@ Similarity ^@ Belongs to the ribose 5-phosphate isomerase family. http://togogenome.org/gene/28377:ptprn2 ^@ http://purl.uniprot.org/uniprot/A0A803U0W4 ^@ Subcellular Location Annotation ^@ Membrane|||secretory vesicle membrane http://togogenome.org/gene/28377:efemp1 ^@ http://purl.uniprot.org/uniprot/A0A803U1U1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:mcm2 ^@ http://purl.uniprot.org/uniprot/G1KGN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/28377:mrps36 ^@ http://purl.uniprot.org/uniprot/G1KSK8 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/28377:LOC100561305 ^@ http://purl.uniprot.org/uniprot/A0A803SY83 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:chchd4 ^@ http://purl.uniprot.org/uniprot/G1KP24 ^@ Subcellular Location Annotation ^@ Mitochondrion intermembrane space http://togogenome.org/gene/28377:ssbp2 ^@ http://purl.uniprot.org/uniprot/A0A803T347|||http://purl.uniprot.org/uniprot/R4GBL2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:rpl19 ^@ http://purl.uniprot.org/uniprot/A0A803SMV5 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/28377:hacl1 ^@ http://purl.uniprot.org/uniprot/G1KAP3 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/28377:erlec1 ^@ http://purl.uniprot.org/uniprot/G1KM94 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OS-9 family.|||Endoplasmic reticulum lumen|||Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. http://togogenome.org/gene/28377:c3h11orf73 ^@ http://purl.uniprot.org/uniprot/A0A803TJ45 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.|||Belongs to the OPI10 family.|||Cytoplasm|||Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.|||Nucleus|||cytosol http://togogenome.org/gene/28377:cebpb ^@ http://purl.uniprot.org/uniprot/G1KR93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/28377:asun ^@ http://purl.uniprot.org/uniprot/A0A803SSA3|||http://purl.uniprot.org/uniprot/G1KLZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the asunder family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:dock8 ^@ http://purl.uniprot.org/uniprot/A0A803TZW6|||http://purl.uniprot.org/uniprot/G1KAF3 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/28377:smim8 ^@ http://purl.uniprot.org/uniprot/G1KQS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM8 family.|||Membrane http://togogenome.org/gene/28377:dus4l ^@ http://purl.uniprot.org/uniprot/G1KQT0 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. http://togogenome.org/gene/28377:psen2 ^@ http://purl.uniprot.org/uniprot/G1KFF8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||The PAL motif is required for normal active site conformation. http://togogenome.org/gene/28377:LOC100564372 ^@ http://purl.uniprot.org/uniprot/G1KIS3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:mfsd6l ^@ http://purl.uniprot.org/uniprot/A0A803TKR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. MFSD6 family.|||Membrane http://togogenome.org/gene/28377:camk2a ^@ http://purl.uniprot.org/uniprot/A0A803TQZ5|||http://purl.uniprot.org/uniprot/L7MZY1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/28377:samm50 ^@ http://purl.uniprot.org/uniprot/G1KRW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAM50/omp85 family.|||Mitochondrion outer membrane http://togogenome.org/gene/28377:scn8a ^@ http://purl.uniprot.org/uniprot/A0A803TCI4|||http://purl.uniprot.org/uniprot/F9W2Y6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/28377:nxpe3 ^@ http://purl.uniprot.org/uniprot/A0A803TK30|||http://purl.uniprot.org/uniprot/G1KLU5 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/28377:tmem251 ^@ http://purl.uniprot.org/uniprot/G1KI71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LYSET family.|||Membrane http://togogenome.org/gene/28377:sfxn2 ^@ http://purl.uniprot.org/uniprot/G1KCP7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/28377:gpr25 ^@ http://purl.uniprot.org/uniprot/G1KJP2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:numbl ^@ http://purl.uniprot.org/uniprot/A0A803TG76 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Plays a role in the process of neurogenesis. http://togogenome.org/gene/28377:pp ^@ http://purl.uniprot.org/uniprot/G1KLK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/28377:vegfc ^@ http://purl.uniprot.org/uniprot/G1KEU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/28377:lrp12 ^@ http://purl.uniprot.org/uniprot/A0A803TLY6|||http://purl.uniprot.org/uniprot/G1KJE0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:inhba ^@ http://purl.uniprot.org/uniprot/G1KU54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/28377:rpap2 ^@ http://purl.uniprot.org/uniprot/A0A803TE38|||http://purl.uniprot.org/uniprot/G1KCW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the RPAP2 family.|||Nucleus|||Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. http://togogenome.org/gene/28377:uxt ^@ http://purl.uniprot.org/uniprot/G1KD45 ^@ Similarity ^@ Belongs to the UXT family. http://togogenome.org/gene/28377:rab3c ^@ http://purl.uniprot.org/uniprot/G1KIQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/28377:ggps1 ^@ http://purl.uniprot.org/uniprot/G1K9G5 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/28377:clstn2 ^@ http://purl.uniprot.org/uniprot/A0A803TI45|||http://purl.uniprot.org/uniprot/G1KC08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calsyntenin family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Postsynaptic cell membrane http://togogenome.org/gene/28377:rybp ^@ http://purl.uniprot.org/uniprot/A0A803TAL8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:osbpl3 ^@ http://purl.uniprot.org/uniprot/A0A803TZF3|||http://purl.uniprot.org/uniprot/G1KND1 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/28377:eny2 ^@ http://purl.uniprot.org/uniprot/A0A803T5D0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2). Component of the SAGA transcription coactivator-HAT complex. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.|||nucleoplasm http://togogenome.org/gene/28377:epc1 ^@ http://purl.uniprot.org/uniprot/G1KG32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/28377:rab18 ^@ http://purl.uniprot.org/uniprot/A0A803TH47 ^@ Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Lipid droplet http://togogenome.org/gene/28377:adcyap1r1 ^@ http://purl.uniprot.org/uniprot/A0A803THH6|||http://purl.uniprot.org/uniprot/G1KFA9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:wee2 ^@ http://purl.uniprot.org/uniprot/G1KL87 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.|||Binds 2 magnesium ions per subunit.|||Nucleus http://togogenome.org/gene/28377:mrps31 ^@ http://purl.uniprot.org/uniprot/G1KSV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS31 family.|||Mitochondrion http://togogenome.org/gene/28377:pgs1 ^@ http://purl.uniprot.org/uniprot/G1KSY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-II family.|||Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.|||Mitochondrion http://togogenome.org/gene/28377:sh3glb1 ^@ http://purl.uniprot.org/uniprot/A0A803TCX9|||http://purl.uniprot.org/uniprot/R4GCT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Cytoplasm|||Golgi apparatus membrane|||Mitochondrion outer membrane http://togogenome.org/gene/28377:rdh10 ^@ http://purl.uniprot.org/uniprot/A0A803TJ01 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:ppfia3 ^@ http://purl.uniprot.org/uniprot/A0A803TVP1 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/28377:ctnnbip1 ^@ http://purl.uniprot.org/uniprot/A0A803TVA7 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/28377:ppp1r12b ^@ http://purl.uniprot.org/uniprot/A0A803T4E8|||http://purl.uniprot.org/uniprot/R4GAW3 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits. http://togogenome.org/gene/28377:LOC100564769 ^@ http://purl.uniprot.org/uniprot/G1KMX1 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/28377:itpkc ^@ http://purl.uniprot.org/uniprot/H9GJZ6 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/28377:ndp ^@ http://purl.uniprot.org/uniprot/G1KUH6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:gadd45gip1 ^@ http://purl.uniprot.org/uniprot/G1KTI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.|||Belongs to the mitochondrion-specific ribosomal protein mL64 family.|||Mitochondrion|||Nucleus http://togogenome.org/gene/28377:c4h8orf46 ^@ http://purl.uniprot.org/uniprot/A0A803TGW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vexin family.|||Cell membrane|||Membrane|||Nucleus http://togogenome.org/gene/28377:mcph1 ^@ http://purl.uniprot.org/uniprot/G1KVY5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.|||Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions.|||centrosome http://togogenome.org/gene/28377:npvf ^@ http://purl.uniprot.org/uniprot/G1KN65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||Secreted http://togogenome.org/gene/28377:wasf1 ^@ http://purl.uniprot.org/uniprot/G1KKG8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/28377:c3h21orf59 ^@ http://purl.uniprot.org/uniprot/G1KBD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP298 family.|||cilium basal body http://togogenome.org/gene/28377:acsf2 ^@ http://purl.uniprot.org/uniprot/G1KDS5 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/28377:rps13 ^@ http://purl.uniprot.org/uniprot/G1K874 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/28377:ror1 ^@ http://purl.uniprot.org/uniprot/G1KHM7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:gpbp1l1 ^@ http://purl.uniprot.org/uniprot/G1KRH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/28377:cpeb4 ^@ http://purl.uniprot.org/uniprot/A0A803SUH2|||http://purl.uniprot.org/uniprot/G1KQM8 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/28377:b3gnt2 ^@ http://purl.uniprot.org/uniprot/G1KEJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:ptpn12 ^@ http://purl.uniprot.org/uniprot/G1KF66 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. http://togogenome.org/gene/28377:LOC100557873 ^@ http://purl.uniprot.org/uniprot/G1KQX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/28377:znrd1 ^@ http://purl.uniprot.org/uniprot/G1KL81 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.|||nucleolus http://togogenome.org/gene/28377:elovl1 ^@ http://purl.uniprot.org/uniprot/G1KNR6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL1 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/28377:nrg1 ^@ http://purl.uniprot.org/uniprot/A0A803TMP5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neuregulin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:c4h8orf37 ^@ http://purl.uniprot.org/uniprot/G1KX11 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in photoreceptor outer segment disk morphogenesis.|||Photoreceptor inner segment http://togogenome.org/gene/28377:zdhhc17 ^@ http://purl.uniprot.org/uniprot/G1KFQ3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Cytoplasmic vesicle membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/28377:ddo ^@ http://purl.uniprot.org/uniprot/A0A803TTI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/28377:mrpl16 ^@ http://purl.uniprot.org/uniprot/G1KJH6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/28377:sass6 ^@ http://purl.uniprot.org/uniprot/G1KC00 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/28377:myo6 ^@ http://purl.uniprot.org/uniprot/A0A803TNN6|||http://purl.uniprot.org/uniprot/A0A803TWI5|||http://purl.uniprot.org/uniprot/G1KDE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||clathrin-coated pit|||clathrin-coated vesicle|||filopodium|||microvillus|||ruffle membrane|||trans-Golgi network membrane http://togogenome.org/gene/28377:gnaq ^@ http://purl.uniprot.org/uniprot/G1KEY8 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/28377:ergic3 ^@ http://purl.uniprot.org/uniprot/G1KEP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/28377:susd4 ^@ http://purl.uniprot.org/uniprot/G1KAS8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:kcnc4 ^@ http://purl.uniprot.org/uniprot/G1KMP2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:chdh ^@ http://purl.uniprot.org/uniprot/G1KLE3 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family.|||Belongs to the flavin monoamine oxidase family. FIG1 subfamily. http://togogenome.org/gene/28377:shroom1 ^@ http://purl.uniprot.org/uniprot/A0A803TN87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/28377:syt16 ^@ http://purl.uniprot.org/uniprot/G1KS90 ^@ Similarity ^@ Belongs to the synaptotagmin family. http://togogenome.org/gene/28377:fat3 ^@ http://purl.uniprot.org/uniprot/A0A803SS42|||http://purl.uniprot.org/uniprot/A0A803TH37|||http://purl.uniprot.org/uniprot/A0A803TVX6|||http://purl.uniprot.org/uniprot/G1KQA3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:sgsm3 ^@ http://purl.uniprot.org/uniprot/G1KE59 ^@ Similarity ^@ Belongs to the small G protein signaling modulator family. http://togogenome.org/gene/28377:slc16a5 ^@ http://purl.uniprot.org/uniprot/G1KF31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:tert ^@ http://purl.uniprot.org/uniprot/A0A803STA3|||http://purl.uniprot.org/uniprot/G1K9H7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reverse transcriptase family. Telomerase subfamily.|||Nucleus|||Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.|||telomere http://togogenome.org/gene/28377:mtf2 ^@ http://purl.uniprot.org/uniprot/A0A803TIJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/28377:edem2 ^@ http://purl.uniprot.org/uniprot/G1KHS2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/28377:rtcb ^@ http://purl.uniprot.org/uniprot/G1KQE8 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Catalytic component of the tRNA-splicing ligase complex.|||Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.|||Cytoplasm|||Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP. http://togogenome.org/gene/28377:fam46a ^@ http://purl.uniprot.org/uniprot/A0A803SQZ3 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/28377:samhd1 ^@ http://purl.uniprot.org/uniprot/G1KG42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAMHD1 family.|||Chromosome http://togogenome.org/gene/28377:sh3gl2 ^@ http://purl.uniprot.org/uniprot/A0A803T859 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/28377:neu1 ^@ http://purl.uniprot.org/uniprot/G1KLY3|||http://purl.uniprot.org/uniprot/K0PUN9 ^@ Miscellaneous|||Similarity ^@ Belongs to the glycosyl hydrolase 33 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ third party annotation (TPA) entry. http://togogenome.org/gene/28377:eif3d ^@ http://purl.uniprot.org/uniprot/G1KSG6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit D family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Cytoplasm|||The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.|||mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. http://togogenome.org/gene/28377:eef1a2 ^@ http://purl.uniprot.org/uniprot/G1KEW8 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/28377:LOC100566358 ^@ http://purl.uniprot.org/uniprot/G1KUE6 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/28377:fgfr4 ^@ http://purl.uniprot.org/uniprot/G1KE82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:htr1f ^@ http://purl.uniprot.org/uniprot/G1KP41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.|||Membrane http://togogenome.org/gene/28377:hacd2 ^@ http://purl.uniprot.org/uniprot/G1KKH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:syngr2 ^@ http://purl.uniprot.org/uniprot/G1KT11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/28377:tbce ^@ http://purl.uniprot.org/uniprot/R4GAP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCE family.|||Cytoplasm http://togogenome.org/gene/28377:rag1 ^@ http://purl.uniprot.org/uniprot/G1KDK1 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RAG1 family.|||Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).|||Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.|||Homodimer.|||Nucleus|||The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp. http://togogenome.org/gene/28377:foxd3 ^@ http://purl.uniprot.org/uniprot/G1KHB1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:serinc3 ^@ http://purl.uniprot.org/uniprot/G1KT74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/28377:reep2 ^@ http://purl.uniprot.org/uniprot/G1KGB1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:atxn1 ^@ http://purl.uniprot.org/uniprot/G1KCC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATXN1 family.|||Nucleus http://togogenome.org/gene/28377:pik3cb ^@ http://purl.uniprot.org/uniprot/G1KBQ4 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/28377:dirc2 ^@ http://purl.uniprot.org/uniprot/G1KDG9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:arf1 ^@ http://purl.uniprot.org/uniprot/G1KFW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/28377:grm4 ^@ http://purl.uniprot.org/uniprot/G1KS01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:sp4 ^@ http://purl.uniprot.org/uniprot/A0A803SMN4|||http://purl.uniprot.org/uniprot/G1KPM0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:mrpl32 ^@ http://purl.uniprot.org/uniprot/A0A803SVE8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/28377:sft2d2 ^@ http://purl.uniprot.org/uniprot/G1KKG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/28377:nup133 ^@ http://purl.uniprot.org/uniprot/G1K922 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin Nup133 family.|||nuclear pore complex http://togogenome.org/gene/28377:cnn3 ^@ http://purl.uniprot.org/uniprot/G1KD90 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/28377:LOC100557158 ^@ http://purl.uniprot.org/uniprot/G1KCZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/28377:nell2 ^@ http://purl.uniprot.org/uniprot/G1KB72 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:tmed2 ^@ http://purl.uniprot.org/uniprot/A0A803SS45|||http://purl.uniprot.org/uniprot/A0A803TVV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/28377:slc35d2 ^@ http://purl.uniprot.org/uniprot/A0A803SMD6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:yars2 ^@ http://purl.uniprot.org/uniprot/G1KM69 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/28377:npy1r ^@ http://purl.uniprot.org/uniprot/G1KDK6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:kcnk13 ^@ http://purl.uniprot.org/uniprot/A0A803TQP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/28377:ipo8 ^@ http://purl.uniprot.org/uniprot/A0A803SX82|||http://purl.uniprot.org/uniprot/G1KN53 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/28377:slc4a9 ^@ http://purl.uniprot.org/uniprot/G1KNW1 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/28377:tmed5 ^@ http://purl.uniprot.org/uniprot/G1KEJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/28377:dcstamp ^@ http://purl.uniprot.org/uniprot/G1KJ52 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:LOC100565626 ^@ http://purl.uniprot.org/uniprot/G1KI31 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:d2hgdh ^@ http://purl.uniprot.org/uniprot/G1K8L8 ^@ Similarity ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family. http://togogenome.org/gene/28377:LOC100563983 ^@ http://purl.uniprot.org/uniprot/G1KI33 ^@ Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 56 family.|||Monomer. http://togogenome.org/gene/28377:fut8 ^@ http://purl.uniprot.org/uniprot/G1KA08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 23 family.|||Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/28377:fgb ^@ http://purl.uniprot.org/uniprot/G1KRF4 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/28377:tubgcp3 ^@ http://purl.uniprot.org/uniprot/G1KFE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/28377:cxcr1 ^@ http://purl.uniprot.org/uniprot/G1K910 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:LOC100564326 ^@ http://purl.uniprot.org/uniprot/G1KFK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:qtrt1 ^@ http://purl.uniprot.org/uniprot/G1KRB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.|||Cytoplasm|||Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.|||Mitochondrion outer membrane http://togogenome.org/gene/28377:fmo5 ^@ http://purl.uniprot.org/uniprot/G1KYK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters.|||Belongs to the FMO family.|||Belongs to the flavin monoamine oxidase family. FIG1 subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/28377:gipc1 ^@ http://purl.uniprot.org/uniprot/G1KTE8 ^@ Similarity ^@ Belongs to the GIPC family. http://togogenome.org/gene/28377:LOC100557878 ^@ http://purl.uniprot.org/uniprot/R4GBT6 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/28377:lss ^@ http://purl.uniprot.org/uniprot/G1KDD4 ^@ Similarity ^@ Belongs to the terpene cyclase/mutase family. http://togogenome.org/gene/28377:olfm3 ^@ http://purl.uniprot.org/uniprot/A0A803T5C9|||http://purl.uniprot.org/uniprot/G1KBH1 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/28377:dusp16 ^@ http://purl.uniprot.org/uniprot/G1KCT0 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/28377:atp6v1e1 ^@ http://purl.uniprot.org/uniprot/G1KMC4 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/28377:pdia4 ^@ http://purl.uniprot.org/uniprot/G1KPJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/28377:LOC100563862 ^@ http://purl.uniprot.org/uniprot/G1KKW2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:xpot ^@ http://purl.uniprot.org/uniprot/G1KBN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus|||tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. http://togogenome.org/gene/28377:ovol2 ^@ http://purl.uniprot.org/uniprot/G1KPM6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:sod2 ^@ http://purl.uniprot.org/uniprot/G1KCW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems.|||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.|||Homotetramer.|||Mitochondrion matrix http://togogenome.org/gene/28377:ippk ^@ http://purl.uniprot.org/uniprot/G1KIF2 ^@ Domain|||Function|||Similarity ^@ Belongs to the IPK1 type 2 family.|||Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).|||The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2. http://togogenome.org/gene/28377:c1h14orf169 ^@ http://purl.uniprot.org/uniprot/A0A803SWF3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ROX family.|||Binds 1 Fe(2+) ion per subunit.|||Nucleus|||Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. http://togogenome.org/gene/28377:smim19 ^@ http://purl.uniprot.org/uniprot/G1KIM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM19 family.|||Membrane http://togogenome.org/gene/28377:phtf1 ^@ http://purl.uniprot.org/uniprot/G1K8C4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:pvalb ^@ http://purl.uniprot.org/uniprot/G1KSC8 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/28377:LOC100561762 ^@ http://purl.uniprot.org/uniprot/G1KT94 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:trmu ^@ http://purl.uniprot.org/uniprot/G1KH08 ^@ Function|||Similarity ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. http://togogenome.org/gene/28377:adgra3 ^@ http://purl.uniprot.org/uniprot/G1K980 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/28377:osgin2 ^@ http://purl.uniprot.org/uniprot/G1KK32 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. FIG1 subfamily. http://togogenome.org/gene/28377:colec12 ^@ http://purl.uniprot.org/uniprot/G1KHR4 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/28377:sost ^@ http://purl.uniprot.org/uniprot/A0A803TJI0 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:mettl4 ^@ http://purl.uniprot.org/uniprot/G1KI45 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/28377:slc25a6 ^@ http://purl.uniprot.org/uniprot/A0A803TIW0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/28377:chrm3 ^@ http://purl.uniprot.org/uniprot/G1KC26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/28377:fdxr ^@ http://purl.uniprot.org/uniprot/G1KEM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferredoxin--NADP reductase type 1 family.|||Belongs to the flavin monoamine oxidase family. FIG1 subfamily.|||Mitochondrion|||Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. http://togogenome.org/gene/28377:spc24 ^@ http://purl.uniprot.org/uniprot/A0A803TPC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC24 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/28377:slc46a2 ^@ http://purl.uniprot.org/uniprot/G1KTV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:stk38 ^@ http://purl.uniprot.org/uniprot/G1KSU7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/28377:itga2 ^@ http://purl.uniprot.org/uniprot/G1KCG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/28377:gpt2 ^@ http://purl.uniprot.org/uniprot/H9GK05 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/28377:pter ^@ http://purl.uniprot.org/uniprot/G1KSW9 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.|||Binds 2 divalent metal cations per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:mab21l2 ^@ http://purl.uniprot.org/uniprot/A0A803T3X3 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/28377:ppp1r9a ^@ http://purl.uniprot.org/uniprot/G1KVZ2 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/28377:ppm1k ^@ http://purl.uniprot.org/uniprot/G1KMY3 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/28377:LOC100563006 ^@ http://purl.uniprot.org/uniprot/R4GBS8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/28377:fmnl1 ^@ http://purl.uniprot.org/uniprot/A0A803SMZ0|||http://purl.uniprot.org/uniprot/G1KSN7 ^@ Similarity ^@ Belongs to the formin homology family. http://togogenome.org/gene/28377:cnot7 ^@ http://purl.uniprot.org/uniprot/G1KF69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/28377:igf1 ^@ http://purl.uniprot.org/uniprot/A0A803TEA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/28377:carnmt1 ^@ http://purl.uniprot.org/uniprot/R4GAZ3 ^@ Similarity ^@ Belongs to the carnosine N-methyltransferase family. http://togogenome.org/gene/28377:gclm ^@ http://purl.uniprot.org/uniprot/G1KDY6 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.|||Heterodimer of a catalytic heavy chain and a regulatory light chain. http://togogenome.org/gene/28377:nipal2 ^@ http://purl.uniprot.org/uniprot/G1KS65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/28377:stat1 ^@ http://purl.uniprot.org/uniprot/G1KF84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:rplp1 ^@ http://purl.uniprot.org/uniprot/G1K8D7 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/28377:mdm4 ^@ http://purl.uniprot.org/uniprot/G1KGI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.|||Nucleus http://togogenome.org/gene/28377:tead3 ^@ http://purl.uniprot.org/uniprot/G1KIN3|||http://purl.uniprot.org/uniprot/R4GA16 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. http://togogenome.org/gene/28377:fam53b ^@ http://purl.uniprot.org/uniprot/G1KPU2 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/28377:sfrp5 ^@ http://purl.uniprot.org/uniprot/G1KBI3 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:rpl22l1 ^@ http://purl.uniprot.org/uniprot/G1KS27 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/28377:nceh1 ^@ http://purl.uniprot.org/uniprot/G1KSJ9 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/28377:cndp2 ^@ http://purl.uniprot.org/uniprot/G1KC62 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/28377:nop14 ^@ http://purl.uniprot.org/uniprot/G1KDZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP14 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.|||nucleolus http://togogenome.org/gene/28377:itga3 ^@ http://purl.uniprot.org/uniprot/A0A803U0C7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:zpbp ^@ http://purl.uniprot.org/uniprot/G1KHI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the zona pellucida-binding protein Sp38 family.|||Secreted|||acrosome http://togogenome.org/gene/28377:otc ^@ http://purl.uniprot.org/uniprot/G1KQ60 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily.|||Homotrimer. http://togogenome.org/gene/28377:slc22a3 ^@ http://purl.uniprot.org/uniprot/G1KBW0 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/28377:lclat1 ^@ http://purl.uniprot.org/uniprot/A0A803TUY3 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/28377:slc7a1 ^@ http://purl.uniprot.org/uniprot/G1KCP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:ipo11 ^@ http://purl.uniprot.org/uniprot/A0A803TJL0|||http://purl.uniprot.org/uniprot/G1KHV5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/28377:slc35b1 ^@ http://purl.uniprot.org/uniprot/G1KDE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/28377:fbxo25 ^@ http://purl.uniprot.org/uniprot/G1KDX9|||http://purl.uniprot.org/uniprot/R4GBM6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:srp9 ^@ http://purl.uniprot.org/uniprot/G1KEM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP9 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm http://togogenome.org/gene/28377:kif5b ^@ http://purl.uniprot.org/uniprot/G1KGA8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/28377:phlda3 ^@ http://purl.uniprot.org/uniprot/G1KC58 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/28377:vill ^@ http://purl.uniprot.org/uniprot/G1KE69 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/28377:arid1b ^@ http://purl.uniprot.org/uniprot/A0A803SL05|||http://purl.uniprot.org/uniprot/A0A803TRD5|||http://purl.uniprot.org/uniprot/A0A803TU99|||http://purl.uniprot.org/uniprot/G1KDQ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:vat1 ^@ http://purl.uniprot.org/uniprot/G1KNV6 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/28377:yif1b ^@ http://purl.uniprot.org/uniprot/H9G8A4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/28377:slc9a8 ^@ http://purl.uniprot.org/uniprot/G1KRI9 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. http://togogenome.org/gene/28377:mpc2 ^@ http://purl.uniprot.org/uniprot/G1KIW3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/28377:tspan31 ^@ http://purl.uniprot.org/uniprot/A0A803TN97 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:kcns3 ^@ http://purl.uniprot.org/uniprot/G1K9L4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:b4galt4 ^@ http://purl.uniprot.org/uniprot/G1KCW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/28377:insig2 ^@ http://purl.uniprot.org/uniprot/A0A803TSZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/28377:hlcs ^@ http://purl.uniprot.org/uniprot/G1KI79 ^@ Similarity ^@ Belongs to the biotin--protein ligase family. http://togogenome.org/gene/28377:nmt1 ^@ http://purl.uniprot.org/uniprot/A0A803T143|||http://purl.uniprot.org/uniprot/G1KGM0 ^@ Function|||Similarity ^@ Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.|||Belongs to the NMT family. http://togogenome.org/gene/28377:klkb1 ^@ http://purl.uniprot.org/uniprot/G1K9G8 ^@ Similarity ^@ Belongs to the peptidase S1 family. Snake venom subfamily. http://togogenome.org/gene/28377:gpn3 ^@ http://purl.uniprot.org/uniprot/H9GMW0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.|||Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/28377:aass ^@ http://purl.uniprot.org/uniprot/A0A803TXH5|||http://purl.uniprot.org/uniprot/G1KFR3 ^@ Similarity ^@ In the C-terminal section; belongs to the saccharopine dehydrogenase family.|||In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/28377:araf ^@ http://purl.uniprot.org/uniprot/G1KL07 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/28377:rfx1 ^@ http://purl.uniprot.org/uniprot/A0A803SWQ3|||http://purl.uniprot.org/uniprot/A0A803TI98|||http://purl.uniprot.org/uniprot/A0A803TNS8|||http://purl.uniprot.org/uniprot/G1KRG3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:glis3 ^@ http://purl.uniprot.org/uniprot/A0A803T5Z4|||http://purl.uniprot.org/uniprot/G1KBV5 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/28377:c2h17orf80 ^@ http://purl.uniprot.org/uniprot/A0A803T0U7 ^@ Function|||Similarity ^@ Belongs to the ATPase F chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. http://togogenome.org/gene/28377:rtn4ip1 ^@ http://purl.uniprot.org/uniprot/R4GCV2 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/28377:dgkb ^@ http://purl.uniprot.org/uniprot/G1KN57 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/28377:rps6 ^@ http://purl.uniprot.org/uniprot/G1KU84 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/28377:haus3 ^@ http://purl.uniprot.org/uniprot/G1KN52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS3 family.|||spindle http://togogenome.org/gene/28377:rpl10 ^@ http://purl.uniprot.org/uniprot/G1KHH7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/28377:ggact ^@ http://purl.uniprot.org/uniprot/G1KBZ7 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family.|||Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. http://togogenome.org/gene/28377:dnmbp ^@ http://purl.uniprot.org/uniprot/G1KCK3 ^@ Subcellular Location Annotation ^@ Cell junction|||Golgi stack|||Synapse|||cytoskeleton http://togogenome.org/gene/28377:rnh1 ^@ http://purl.uniprot.org/uniprot/G1KQE3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.|||Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. http://togogenome.org/gene/28377:rab21 ^@ http://purl.uniprot.org/uniprot/G1KGJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cleavage furrow|||Early endosome membrane|||Endoplasmic reticulum membrane|||trans-Golgi network http://togogenome.org/gene/28377:chd9 ^@ http://purl.uniprot.org/uniprot/H9GN21 ^@ Similarity ^@ Belongs to the SNF2/RAD54 helicase family. http://togogenome.org/gene/28377:LOC100553704 ^@ http://purl.uniprot.org/uniprot/A0A803TC86 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:myo10 ^@ http://purl.uniprot.org/uniprot/A0A803SNS8|||http://purl.uniprot.org/uniprot/G1K8Y4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/28377:LOC100554362 ^@ http://purl.uniprot.org/uniprot/G1KDI5 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. FIG1 subfamily. http://togogenome.org/gene/28377:rpl3 ^@ http://purl.uniprot.org/uniprot/G1KH03 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/28377:sec24d ^@ http://purl.uniprot.org/uniprot/G1KP05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/28377:pfkfb3 ^@ http://purl.uniprot.org/uniprot/A0A803TSP4|||http://purl.uniprot.org/uniprot/A0A803TT92 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/28377:calhm2 ^@ http://purl.uniprot.org/uniprot/G1KDA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/28377:ptk7 ^@ http://purl.uniprot.org/uniprot/G1KDC3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:bora ^@ http://purl.uniprot.org/uniprot/G1K8L4 ^@ Similarity ^@ Belongs to the BORA family. http://togogenome.org/gene/28377:toe1 ^@ http://purl.uniprot.org/uniprot/G1KQR3 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/28377:ephx1 ^@ http://purl.uniprot.org/uniprot/G1KER3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/28377:pnn ^@ http://purl.uniprot.org/uniprot/G1KRV3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pinin family.|||Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.|||Nucleus speckle|||desmosome http://togogenome.org/gene/28377:ranbp9 ^@ http://purl.uniprot.org/uniprot/G1KC27 ^@ Similarity ^@ Belongs to the RANBP9/10 family. http://togogenome.org/gene/28377:fam134c ^@ http://purl.uniprot.org/uniprot/G1KP55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:mki67 ^@ http://purl.uniprot.org/uniprot/A0A803TS10 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:cnp ^@ http://purl.uniprot.org/uniprot/G1KTD6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 2H phosphoesterase superfamily. CNPase family.|||Exists as monomers and homodimers.|||Melanosome|||Membrane http://togogenome.org/gene/28377:sucnr1 ^@ http://purl.uniprot.org/uniprot/R4G9L5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:slc17a9 ^@ http://purl.uniprot.org/uniprot/G1KE80 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:ezh1 ^@ http://purl.uniprot.org/uniprot/A0A803SVE4|||http://purl.uniprot.org/uniprot/G1KPU3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:hoxc4 ^@ http://purl.uniprot.org/uniprot/G1KKN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/28377:cachd1 ^@ http://purl.uniprot.org/uniprot/A0A803TZ28|||http://purl.uniprot.org/uniprot/G1KHS1 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/28377:LOC100560433 ^@ http://purl.uniprot.org/uniprot/R4GBM1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:kat2a ^@ http://purl.uniprot.org/uniprot/G1KUL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. GCN5 subfamily.|||Nucleus|||centrosome http://togogenome.org/gene/28377:desi1 ^@ http://purl.uniprot.org/uniprot/G1KCY7 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/28377:slc7a6os ^@ http://purl.uniprot.org/uniprot/H9GG60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IWR1/SLC7A6OS family.|||Cytoplasm|||Directs RNA polymerase II nuclear import.|||Nucleus http://togogenome.org/gene/28377:dact2 ^@ http://purl.uniprot.org/uniprot/G1KHV8 ^@ Similarity ^@ Belongs to the dapper family. http://togogenome.org/gene/28377:luc7l3 ^@ http://purl.uniprot.org/uniprot/A0A803TB08 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/28377:cep170b ^@ http://purl.uniprot.org/uniprot/A0A803T6W0|||http://purl.uniprot.org/uniprot/G1KL52 ^@ Similarity ^@ Belongs to the CEP170 family. http://togogenome.org/gene/28377:map3k10 ^@ http://purl.uniprot.org/uniprot/H9GJL5 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Homodimer.|||Homodimerization via the leucine zipper domains is required for autophosphorylation. http://togogenome.org/gene/28377:ncoa7 ^@ http://purl.uniprot.org/uniprot/A0A803TF29|||http://purl.uniprot.org/uniprot/G1KA58 ^@ Similarity ^@ Belongs to the OXR1 family. http://togogenome.org/gene/28377:n4bp3 ^@ http://purl.uniprot.org/uniprot/G1KFJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the N4BP3 family.|||Vesicle|||dendrite http://togogenome.org/gene/28377:irf7 ^@ http://purl.uniprot.org/uniprot/G1KQL4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:cxcr4 ^@ http://purl.uniprot.org/uniprot/G1K8R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Early endosome|||Endosome|||Late endosome|||Lysosome|||Membrane http://togogenome.org/gene/28377:myog ^@ http://purl.uniprot.org/uniprot/G1KD71 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:slc35b2 ^@ http://purl.uniprot.org/uniprot/G1KQ97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/28377:nifk ^@ http://purl.uniprot.org/uniprot/G1KD10 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/28377:pold1 ^@ http://purl.uniprot.org/uniprot/G1KXJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||Nucleus http://togogenome.org/gene/28377:pdp1 ^@ http://purl.uniprot.org/uniprot/G1KBZ9 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/28377:wdr48 ^@ http://purl.uniprot.org/uniprot/G1KIZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR48 family.|||Late endosome http://togogenome.org/gene/28377:agpat1 ^@ http://purl.uniprot.org/uniprot/A0A803TN66 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/28377:fam183a ^@ http://purl.uniprot.org/uniprot/R4GC79 ^@ Similarity ^@ Belongs to the CFAP144 family. http://togogenome.org/gene/28377:myoz2 ^@ http://purl.uniprot.org/uniprot/G1KNR7 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/28377:pde3a ^@ http://purl.uniprot.org/uniprot/G1KU23 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/28377:nr2e1 ^@ http://purl.uniprot.org/uniprot/G1KEV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/28377:slc5a7 ^@ http://purl.uniprot.org/uniprot/G1KAQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/28377:mcm8 ^@ http://purl.uniprot.org/uniprot/G1K8S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/28377:hs3st5 ^@ http://purl.uniprot.org/uniprot/G1KM36 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/28377:abcg1 ^@ http://purl.uniprot.org/uniprot/G1KBK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/28377:riok3 ^@ http://purl.uniprot.org/uniprot/G1K8C9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/28377:dxo ^@ http://purl.uniprot.org/uniprot/G1KLV2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DXO/Dom3Z family.|||Binds 2 magnesium ions.|||Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.|||Nucleus http://togogenome.org/gene/28377:pan2 ^@ http://purl.uniprot.org/uniprot/R4GD02 ^@ Activity Regulation|||Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. PAN2 subfamily.|||Binds 2 metal cations per subunit in the catalytic exonuclease domain.|||Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.|||Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.|||Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||P-body|||Positively regulated by the regulatory subunit PAN3.|||The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3. http://togogenome.org/gene/28377:nr4a3 ^@ http://purl.uniprot.org/uniprot/G1KIE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/28377:clrn3 ^@ http://purl.uniprot.org/uniprot/G1KGL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/28377:etnppl ^@ http://purl.uniprot.org/uniprot/A0A803TRI4 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/28377:abcc10 ^@ http://purl.uniprot.org/uniprot/G1KJ39 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:LOC100557660 ^@ http://purl.uniprot.org/uniprot/A0A803T425 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:arfgef1 ^@ http://purl.uniprot.org/uniprot/A0A803TUZ0 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||perinuclear region http://togogenome.org/gene/28377:atp2c1 ^@ http://purl.uniprot.org/uniprot/G1KAI3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:mb ^@ http://purl.uniprot.org/uniprot/G1KST1 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/28377:pmpcb ^@ http://purl.uniprot.org/uniprot/G1KFG6 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/28377:utp18 ^@ http://purl.uniprot.org/uniprot/G1KAS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat UTP18 family.|||nucleolus http://togogenome.org/gene/28377:map3k8 ^@ http://purl.uniprot.org/uniprot/G1KGS0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/28377:bcdin3d ^@ http://purl.uniprot.org/uniprot/G1KHR3 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/28377:mael ^@ http://purl.uniprot.org/uniprot/R4GC38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the maelstrom family.|||Nucleus|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage. http://togogenome.org/gene/28377:ccni ^@ http://purl.uniprot.org/uniprot/G1KM05 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/28377:dusp8 ^@ http://purl.uniprot.org/uniprot/R4GDI9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/28377:cstf3 ^@ http://purl.uniprot.org/uniprot/G1KBE9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:borcs5 ^@ http://purl.uniprot.org/uniprot/G1KCT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS5 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/28377:LOC100557938 ^@ http://purl.uniprot.org/uniprot/A0A803T919 ^@ Function|||Similarity ^@ Belongs to the ohanin/vespryn family.|||Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal. http://togogenome.org/gene/28377:thnsl2 ^@ http://purl.uniprot.org/uniprot/G1KHS9 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/28377:slc6a17 ^@ http://purl.uniprot.org/uniprot/G1KMN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/28377:pcid2 ^@ http://purl.uniprot.org/uniprot/G1K8D9 ^@ Similarity ^@ Belongs to the CSN12 family. http://togogenome.org/gene/28377:glra2 ^@ http://purl.uniprot.org/uniprot/G1KKB4|||http://purl.uniprot.org/uniprot/H9GFL1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/28377:LOC100563798 ^@ http://purl.uniprot.org/uniprot/G1KES1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/28377:agpat3 ^@ http://purl.uniprot.org/uniprot/G1KUF3 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/28377:tspo2 ^@ http://purl.uniprot.org/uniprot/A0A803SYB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/28377:mdk ^@ http://purl.uniprot.org/uniprot/A0A803T2L7 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/28377:aldh9a1 ^@ http://purl.uniprot.org/uniprot/G1KNT0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/28377:LOC107982633 ^@ http://purl.uniprot.org/uniprot/G1KY08 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family. Snake venom subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:chst11 ^@ http://purl.uniprot.org/uniprot/G1KRU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:scg5 ^@ http://purl.uniprot.org/uniprot/G1KRQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 7B2 family.|||Secreted http://togogenome.org/gene/28377:hoxc11 ^@ http://purl.uniprot.org/uniprot/G1KKK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/28377:tmem161b ^@ http://purl.uniprot.org/uniprot/A0A803SRT1|||http://purl.uniprot.org/uniprot/G1K8K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM161 family.|||Membrane http://togogenome.org/gene/28377:plrg1 ^@ http://purl.uniprot.org/uniprot/G1KRH3 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/28377:LOC100557872 ^@ http://purl.uniprot.org/uniprot/G1KR15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/28377:itpr3 ^@ http://purl.uniprot.org/uniprot/G1KSL8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the InsP3 receptor family.|||Endoplasmic reticulum membrane|||Homotetramer.|||Membrane|||Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.|||The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. http://togogenome.org/gene/28377:cpne4 ^@ http://purl.uniprot.org/uniprot/G1K9L1 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/28377:sufu ^@ http://purl.uniprot.org/uniprot/G1KCJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SUFU family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:pnldc1 ^@ http://purl.uniprot.org/uniprot/G1KP33 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/28377:osgin1 ^@ http://purl.uniprot.org/uniprot/A0A803TC54 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. FIG1 subfamily. http://togogenome.org/gene/28377:dtd1 ^@ http://purl.uniprot.org/uniprot/G1KG77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DTD family.|||Cytoplasm http://togogenome.org/gene/28377:cd47 ^@ http://purl.uniprot.org/uniprot/R4GAV1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/28377:snap25 ^@ http://purl.uniprot.org/uniprot/G1KA11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.|||synaptosome http://togogenome.org/gene/28377:ctsl ^@ http://purl.uniprot.org/uniprot/A0A803TVI0 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/28377:lamb3 ^@ http://purl.uniprot.org/uniprot/G1KEN9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:nucb2 ^@ http://purl.uniprot.org/uniprot/A0A803SP67 ^@ Similarity ^@ Belongs to the nucleobindin family. http://togogenome.org/gene/28377:c6h18orf21 ^@ http://purl.uniprot.org/uniprot/G1KFS9 ^@ Similarity ^@ Belongs to the UPF0711 family. http://togogenome.org/gene/28377:mmp24 ^@ http://purl.uniprot.org/uniprot/G1KE46 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/28377:gjd3 ^@ http://purl.uniprot.org/uniprot/G1KAM8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/28377:myadml2 ^@ http://purl.uniprot.org/uniprot/L7MZV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/28377:mettl16 ^@ http://purl.uniprot.org/uniprot/G1KT98 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METTL16/RlmF family.|||RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. http://togogenome.org/gene/28377:prok1 ^@ http://purl.uniprot.org/uniprot/A0A803TFD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/28377:grm3 ^@ http://purl.uniprot.org/uniprot/G1KSM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.|||Interacts with TAMALIN.|||Membrane http://togogenome.org/gene/28377:slc28a3 ^@ http://purl.uniprot.org/uniprot/G1K9F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/28377:atg3 ^@ http://purl.uniprot.org/uniprot/G1KJY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG3 family.|||Cytoplasm http://togogenome.org/gene/28377:oxct1 ^@ http://purl.uniprot.org/uniprot/G1KKA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 3-oxoacid CoA-transferase family.|||Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.|||Mitochondrion http://togogenome.org/gene/28377:hbegf ^@ http://purl.uniprot.org/uniprot/A0A803SZA9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:odf1 ^@ http://purl.uniprot.org/uniprot/G1KII8 ^@ Function|||Similarity ^@ Belongs to the small heat shock protein (HSP20) family.|||Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. http://togogenome.org/gene/28377:crbn ^@ http://purl.uniprot.org/uniprot/G1KEF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRBN family.|||Nucleus http://togogenome.org/gene/28377:LOC100562614 ^@ http://purl.uniprot.org/uniprot/G1KE01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/28377:st13 ^@ http://purl.uniprot.org/uniprot/G1KDW2 ^@ Similarity ^@ Belongs to the FAM10 family. http://togogenome.org/gene/28377:tp53i11 ^@ http://purl.uniprot.org/uniprot/G1KPZ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:stard3 ^@ http://purl.uniprot.org/uniprot/G1KCA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Membrane http://togogenome.org/gene/28377:meox1 ^@ http://purl.uniprot.org/uniprot/A0A803SPM2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:nampt ^@ http://purl.uniprot.org/uniprot/A0A803TNL4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAPRTase family.|||Cytoplasm|||Homodimer.|||Nucleus|||Secreted http://togogenome.org/gene/28377:fzd4 ^@ http://purl.uniprot.org/uniprot/G1KB27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100553036 ^@ http://purl.uniprot.org/uniprot/G1KWS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:stmn2 ^@ http://purl.uniprot.org/uniprot/G1KNP8 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/28377:fam13b ^@ http://purl.uniprot.org/uniprot/A0A803THG0|||http://purl.uniprot.org/uniprot/G1KYA6 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/28377:stk17a ^@ http://purl.uniprot.org/uniprot/G1KU03 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/28377:mgat5 ^@ http://purl.uniprot.org/uniprot/G1KAW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 18 family.|||Golgi apparatus membrane|||Membrane|||Secreted http://togogenome.org/gene/28377:sh3bp5 ^@ http://purl.uniprot.org/uniprot/G1KB58 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SH3BP5 family.|||Cytoplasm|||Functions as guanine nucleotide exchange factor (GEF) for RAB11A.|||Interacts with GDP-bound and nucleotide-free forms of RAB11A.|||The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. http://togogenome.org/gene/28377:prmt3 ^@ http://purl.uniprot.org/uniprot/G1KRB4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/28377:cenpm ^@ http://purl.uniprot.org/uniprot/A0A803TL21 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:tspo ^@ http://purl.uniprot.org/uniprot/G1KRS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/28377:LOC100560069 ^@ http://purl.uniprot.org/uniprot/A0A803SS94 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:slc16a7 ^@ http://purl.uniprot.org/uniprot/G1K9H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/28377:nup50 ^@ http://purl.uniprot.org/uniprot/G1KRG1 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/28377:rcan1 ^@ http://purl.uniprot.org/uniprot/A0A803TDZ0|||http://purl.uniprot.org/uniprot/G1KDK3 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/28377:tmem9 ^@ http://purl.uniprot.org/uniprot/A0A803TFB3 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/28377:c1d ^@ http://purl.uniprot.org/uniprot/G1K9A3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the C1D family.|||Cytoplasm|||Monomer and homodimer.|||Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.|||nucleolus http://togogenome.org/gene/28377:LOC100559260 ^@ http://purl.uniprot.org/uniprot/G1KF19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/28377:bag6 ^@ http://purl.uniprot.org/uniprot/G1KM96 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).|||cytosol|||extracellular exosome http://togogenome.org/gene/28377:steap2 ^@ http://purl.uniprot.org/uniprot/G1KRT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/28377:fam198a ^@ http://purl.uniprot.org/uniprot/G1KBI0 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/28377:stk10 ^@ http://purl.uniprot.org/uniprot/G1KR20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Cell membrane http://togogenome.org/gene/28377:hmga1 ^@ http://purl.uniprot.org/uniprot/G1KRT7|||http://purl.uniprot.org/uniprot/G1KY66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGA family.|||Nucleus http://togogenome.org/gene/28377:tcp11l1 ^@ http://purl.uniprot.org/uniprot/G1KB66 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/28377:nectin3 ^@ http://purl.uniprot.org/uniprot/A0A803TA84|||http://purl.uniprot.org/uniprot/A0A803TNU5|||http://purl.uniprot.org/uniprot/G1KHA1 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/28377:LOC100555013 ^@ http://purl.uniprot.org/uniprot/G1KM29 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/28377:tlr3 ^@ http://purl.uniprot.org/uniprot/G1K9T8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/28377:inpp5d ^@ http://purl.uniprot.org/uniprot/G1KF42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.|||Membrane http://togogenome.org/gene/28377:LOC100564568 ^@ http://purl.uniprot.org/uniprot/G1KMU4 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/28377:mnf1 ^@ http://purl.uniprot.org/uniprot/A0A803T101 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/28377:tcte3 ^@ http://purl.uniprot.org/uniprot/G1KB55 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/28377:mcrip1 ^@ http://purl.uniprot.org/uniprot/G1KKC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCRIP family.|||Nucleus|||Stress granule http://togogenome.org/gene/28377:sdha ^@ http://purl.uniprot.org/uniprot/G1KJ75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Belongs to the flavin monoamine oxidase family. FIG1 subfamily.|||Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/28377:LOC100555314 ^@ http://purl.uniprot.org/uniprot/G1KTZ2 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/28377:gtdc1 ^@ http://purl.uniprot.org/uniprot/A0A803SNW6|||http://purl.uniprot.org/uniprot/A0A803T476|||http://purl.uniprot.org/uniprot/G1KBG8 ^@ Similarity ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. http://togogenome.org/gene/28377:LOC100560189 ^@ http://purl.uniprot.org/uniprot/R4GBA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/28377:LOC100560052 ^@ http://purl.uniprot.org/uniprot/A0A803SSH4|||http://purl.uniprot.org/uniprot/G1K997 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/28377:LOC100553954 ^@ http://purl.uniprot.org/uniprot/G1KSN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/28377:rpf2 ^@ http://purl.uniprot.org/uniprot/G1KL21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/28377:cd8a ^@ http://purl.uniprot.org/uniprot/G1KL70 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/28377:nsmce4a ^@ http://purl.uniprot.org/uniprot/G1KTQ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE4 family.|||Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.|||Component of the SMC5-SMC6 complex.|||Nucleus|||telomere http://togogenome.org/gene/28377:pla2g12a ^@ http://purl.uniprot.org/uniprot/A0A803TGE4 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/28377:med21 ^@ http://purl.uniprot.org/uniprot/G1KM38 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 21 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/28377:ak3 ^@ http://purl.uniprot.org/uniprot/G1KC24 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/28377:mat2b ^@ http://purl.uniprot.org/uniprot/R4G925 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.|||Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.|||Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. http://togogenome.org/gene/28377:fam91a1 ^@ http://purl.uniprot.org/uniprot/G1KJH3 ^@ Similarity ^@ Belongs to the FAM91 family. http://togogenome.org/gene/28377:LOC100554616 ^@ http://purl.uniprot.org/uniprot/A0A803TQN6 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/28377:uba6 ^@ http://purl.uniprot.org/uniprot/G1KNA2 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/28377:ppp3r1 ^@ http://purl.uniprot.org/uniprot/A0A803SNH9|||http://purl.uniprot.org/uniprot/A0A803SU11|||http://purl.uniprot.org/uniprot/A0A803TZD2 ^@ Similarity ^@ Belongs to the calcineurin regulatory subunit family. http://togogenome.org/gene/28377:eif3e ^@ http://purl.uniprot.org/uniprot/G1KJX9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit E family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:pth2r ^@ http://purl.uniprot.org/uniprot/G1KKX5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:suclg1 ^@ http://purl.uniprot.org/uniprot/G1K8H8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. http://togogenome.org/gene/28377:gskip ^@ http://purl.uniprot.org/uniprot/A0A803TYN5 ^@ Similarity ^@ Belongs to the GSKIP family. http://togogenome.org/gene/28377:LOC100554621 ^@ http://purl.uniprot.org/uniprot/G1KM91 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/28377:celf1 ^@ http://purl.uniprot.org/uniprot/G1KAD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:c4h20orf24 ^@ http://purl.uniprot.org/uniprot/G1KJ79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:LOC100554550 ^@ http://purl.uniprot.org/uniprot/G1KN84 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/28377:jak1 ^@ http://purl.uniprot.org/uniprot/G1KI54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|||Endomembrane system http://togogenome.org/gene/28377:abcc3 ^@ http://purl.uniprot.org/uniprot/G1K9J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:sap130 ^@ http://purl.uniprot.org/uniprot/G1KDS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAP130 family.|||Nucleus http://togogenome.org/gene/28377:mbtps1 ^@ http://purl.uniprot.org/uniprot/G1KN46 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/28377:pomgnt1 ^@ http://purl.uniprot.org/uniprot/G1KAX0 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Membrane|||Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.|||The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.|||The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein. http://togogenome.org/gene/28377:LOC100552705 ^@ http://purl.uniprot.org/uniprot/A0A803SPN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/28377:gabrb2 ^@ http://purl.uniprot.org/uniprot/A0A803T7J4|||http://purl.uniprot.org/uniprot/G1KQV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/28377:ppp2ca ^@ http://purl.uniprot.org/uniprot/H9G796 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/28377:id2 ^@ http://purl.uniprot.org/uniprot/A0A803T150 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:ppdpf ^@ http://purl.uniprot.org/uniprot/G1KEX0 ^@ Similarity ^@ Belongs to the PPDPF family. http://togogenome.org/gene/28377:LOC100557693 ^@ http://purl.uniprot.org/uniprot/G1K8Z8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/28377:LOC100562140 ^@ http://purl.uniprot.org/uniprot/G1KKY5 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/28377:gins1 ^@ http://purl.uniprot.org/uniprot/A0A803SNN7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS1/PSF1 family.|||Chromosome|||Component of the GINS complex.|||Nucleus|||Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. http://togogenome.org/gene/28377:acsl6 ^@ http://purl.uniprot.org/uniprot/G1KM83 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. http://togogenome.org/gene/28377:bfsp1 ^@ http://purl.uniprot.org/uniprot/G1KXK6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||cell cortex|||cytoskeleton http://togogenome.org/gene/28377:c3h2orf40 ^@ http://purl.uniprot.org/uniprot/G1KK53 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the augurin family.|||Cytoplasm|||Membrane|||Secreted http://togogenome.org/gene/28377:map2k4 ^@ http://purl.uniprot.org/uniprot/A0A803TC26|||http://purl.uniprot.org/uniprot/G1KTZ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/28377:psmd13 ^@ http://purl.uniprot.org/uniprot/G1KU14 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S11 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/28377:tfeb ^@ http://purl.uniprot.org/uniprot/G1KB16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/28377:tm7sf3 ^@ http://purl.uniprot.org/uniprot/A0A803T749 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:lrrfip1 ^@ http://purl.uniprot.org/uniprot/A0A803SVN5|||http://purl.uniprot.org/uniprot/A0A803T179 ^@ Similarity ^@ Belongs to the LRRFIP family. http://togogenome.org/gene/28377:npffr2 ^@ http://purl.uniprot.org/uniprot/A0A803TWI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/28377:timp3 ^@ http://purl.uniprot.org/uniprot/A0A803SXP8 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/28377:prr5l ^@ http://purl.uniprot.org/uniprot/G1KDP1 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/28377:ip6k2 ^@ http://purl.uniprot.org/uniprot/G1K9X5 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/28377:plcd3 ^@ http://purl.uniprot.org/uniprot/A0A803SY32|||http://purl.uniprot.org/uniprot/A0A803T4T2 ^@ Cofactor ^@ Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. http://togogenome.org/gene/28377:atg4c ^@ http://purl.uniprot.org/uniprot/G1KHE1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/28377:c5ar1 ^@ http://purl.uniprot.org/uniprot/H9G8H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/28377:lace1 ^@ http://purl.uniprot.org/uniprot/G1KEW9 ^@ Similarity ^@ Belongs to the AFG1 ATPase family. http://togogenome.org/gene/28377:tada3 ^@ http://purl.uniprot.org/uniprot/G1KJG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGG1 family.|||Nucleus http://togogenome.org/gene/28377:atxn10 ^@ http://purl.uniprot.org/uniprot/G1KPT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ataxin-10 family.|||Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.|||perinuclear region http://togogenome.org/gene/28377:mylk ^@ http://purl.uniprot.org/uniprot/G1KKG2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. http://togogenome.org/gene/28377:snx5 ^@ http://purl.uniprot.org/uniprot/G1KPK8 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/28377:csnk1d ^@ http://purl.uniprot.org/uniprot/A0A803TIN8|||http://purl.uniprot.org/uniprot/A0A803TR49|||http://purl.uniprot.org/uniprot/G1KAV5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/28377:hmmr ^@ http://purl.uniprot.org/uniprot/R4G9R9 ^@ Subcellular Location Annotation ^@ Nucleus|||spindle http://togogenome.org/gene/28377:nfil3 ^@ http://purl.uniprot.org/uniprot/G1K8V6 ^@ Similarity ^@ Belongs to the bZIP family. NFIL3 subfamily. http://togogenome.org/gene/28377:nr2c2 ^@ http://purl.uniprot.org/uniprot/G1KM19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/28377:pot1 ^@ http://purl.uniprot.org/uniprot/G1K9A9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the telombin family.|||Nucleus|||telomere http://togogenome.org/gene/28377:nup85 ^@ http://purl.uniprot.org/uniprot/G1KF71 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup85 family.|||Component of the nuclear pore complex (NPC).|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/28377:esco1 ^@ http://purl.uniprot.org/uniprot/G1KH60 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:LOC100564904 ^@ http://purl.uniprot.org/uniprot/G1KL93 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/28377:atp5a1 ^@ http://purl.uniprot.org/uniprot/G1KMR9 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/28377:rc3h1 ^@ http://purl.uniprot.org/uniprot/G1KQZ5 ^@ Subcellular Location Annotation ^@ P-body http://togogenome.org/gene/28377:stx3 ^@ http://purl.uniprot.org/uniprot/A0A803T112 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/28377:zdhhc13 ^@ http://purl.uniprot.org/uniprot/R4G950 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Cytoplasmic vesicle membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/28377:LOC100564496 ^@ http://purl.uniprot.org/uniprot/R4GC31 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/28377:slc43a3 ^@ http://purl.uniprot.org/uniprot/A0A803T9S8|||http://purl.uniprot.org/uniprot/G1KGE5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:f2 ^@ http://purl.uniprot.org/uniprot/G1KCA5 ^@ Caution|||Function|||Similarity ^@ Belongs to the peptidase S1 family. Snake venom subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. http://togogenome.org/gene/28377:c1h14orf159 ^@ http://purl.uniprot.org/uniprot/G1KJE6 ^@ Similarity ^@ Belongs to the D-glutamate cyclase family. http://togogenome.org/gene/28377:LOC100558735 ^@ http://purl.uniprot.org/uniprot/G1KAZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/28377:uggt1 ^@ http://purl.uniprot.org/uniprot/G1KDP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 8 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/28377:tm4sf19 ^@ http://purl.uniprot.org/uniprot/G1K8H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/28377:notch3 ^@ http://purl.uniprot.org/uniprot/G1KTN8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOTCH family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Nucleus http://togogenome.org/gene/28377:sec22b ^@ http://purl.uniprot.org/uniprot/A0A803TX37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Melanosome|||Membrane|||SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/28377:olfm4 ^@ http://purl.uniprot.org/uniprot/G1K8G3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:prkd1 ^@ http://purl.uniprot.org/uniprot/A0A803SR45|||http://purl.uniprot.org/uniprot/A0A803TTW3|||http://purl.uniprot.org/uniprot/G1KS05 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by DAG and phorbol esters.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/28377:carm1 ^@ http://purl.uniprot.org/uniprot/A0A803TVL8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:rars2 ^@ http://purl.uniprot.org/uniprot/G1KQM3 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/28377:gprc5a ^@ http://purl.uniprot.org/uniprot/G1KKC9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/28377:hn1 ^@ http://purl.uniprot.org/uniprot/G1KF37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:ccdc65 ^@ http://purl.uniprot.org/uniprot/G1KHL0 ^@ Subcellular Location Annotation ^@ flagellum axoneme http://togogenome.org/gene/28377:ppfia4 ^@ http://purl.uniprot.org/uniprot/A0A803SZR4|||http://purl.uniprot.org/uniprot/G1KDB2 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/28377:faim2 ^@ http://purl.uniprot.org/uniprot/G1KHS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/28377:acvrl1 ^@ http://purl.uniprot.org/uniprot/G1KT96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane|||Secreted http://togogenome.org/gene/28377:inhbb ^@ http://purl.uniprot.org/uniprot/R4GDL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/28377:ss18l1 ^@ http://purl.uniprot.org/uniprot/G1KS70 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/28377:eif3m ^@ http://purl.uniprot.org/uniprot/G1KAY4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Belongs to the eIF-3 subunit M family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/28377:LOC103277774 ^@ http://purl.uniprot.org/uniprot/A0A803THB8 ^@ Similarity ^@ Belongs to the glucagon family. http://togogenome.org/gene/28377:tmem123 ^@ http://purl.uniprot.org/uniprot/G1KMK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane http://togogenome.org/gene/28377:b4galnt3 ^@ http://purl.uniprot.org/uniprot/G1K862 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane|||Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. http://togogenome.org/gene/28377:higd1b ^@ http://purl.uniprot.org/uniprot/A0A803T9Z6 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/28377:mfn1 ^@ http://purl.uniprot.org/uniprot/G1KD85 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/28377:wrb ^@ http://purl.uniprot.org/uniprot/G1KE30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WRB/GET1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:slc25a39 ^@ http://purl.uniprot.org/uniprot/A0A803SR27|||http://purl.uniprot.org/uniprot/G1KTR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/28377:haus1 ^@ http://purl.uniprot.org/uniprot/G1KMM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS1 family.|||spindle http://togogenome.org/gene/28377:LOC103281183 ^@ http://purl.uniprot.org/uniprot/A0A803TUC5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100566938 ^@ http://purl.uniprot.org/uniprot/G1KX50 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/28377:lrrc8c ^@ http://purl.uniprot.org/uniprot/G1K985 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:ehd4 ^@ http://purl.uniprot.org/uniprot/G1KQG3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/28377:laptm4b ^@ http://purl.uniprot.org/uniprot/G1KRY2 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/28377:plaa ^@ http://purl.uniprot.org/uniprot/G1KU18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PLAP family.|||Cytoplasm http://togogenome.org/gene/28377:npffr1 ^@ http://purl.uniprot.org/uniprot/G1KQU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/28377:amd1 ^@ http://purl.uniprot.org/uniprot/G1KKY9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic AdoMetDC family.|||Binds 1 pyruvoyl group covalently per subunit.|||Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. http://togogenome.org/gene/28377:LOC100557280 ^@ http://purl.uniprot.org/uniprot/R4G9T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/28377:cask ^@ http://purl.uniprot.org/uniprot/A0A803T0M4|||http://purl.uniprot.org/uniprot/A0A803U1J1|||http://purl.uniprot.org/uniprot/G1KUI6 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/28377:skp1 ^@ http://purl.uniprot.org/uniprot/A0A803TCY2 ^@ Function|||Similarity ^@ Belongs to the SKP1 family.|||Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. http://togogenome.org/gene/28377:gjc1 ^@ http://purl.uniprot.org/uniprot/G1KLV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Gamma-type subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/28377:osbpl5 ^@ http://purl.uniprot.org/uniprot/G1K896 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/28377:ddx18 ^@ http://purl.uniprot.org/uniprot/G1KAA2 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/28377:chmp4b ^@ http://purl.uniprot.org/uniprot/G1KIA2 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/28377:snx30 ^@ http://purl.uniprot.org/uniprot/G1KTU9 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/28377:farsb ^@ http://purl.uniprot.org/uniprot/A0A803T1L6 ^@ Similarity ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. http://togogenome.org/gene/28377:kdelc2 ^@ http://purl.uniprot.org/uniprot/A0A803T7T2|||http://purl.uniprot.org/uniprot/G1KDW4 ^@ Similarity ^@ Belongs to the KDELC family. http://togogenome.org/gene/28377:atad2 ^@ http://purl.uniprot.org/uniprot/G1KJ60 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/28377:cds1 ^@ http://purl.uniprot.org/uniprot/G1KL44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Membrane http://togogenome.org/gene/28377:patl1 ^@ http://purl.uniprot.org/uniprot/G1KFK1 ^@ Similarity ^@ Belongs to the PAT1 family. http://togogenome.org/gene/28377:slc35f1 ^@ http://purl.uniprot.org/uniprot/G1KPT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/28377:rars ^@ http://purl.uniprot.org/uniprot/A0A803TC76|||http://purl.uniprot.org/uniprot/G1KDF6 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/28377:ngfr ^@ http://purl.uniprot.org/uniprot/G1KD91 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:atp6v1c2 ^@ http://purl.uniprot.org/uniprot/G1KN14 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/28377:slc29a1 ^@ http://purl.uniprot.org/uniprot/R4GAH8 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/28377:optn ^@ http://purl.uniprot.org/uniprot/G1K9C2 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Golgi apparatus|||May act by regulating membrane trafficking and cellular morphogenesis.|||Recycling endosome|||autophagosome|||perinuclear region|||trans-Golgi network http://togogenome.org/gene/28377:canx ^@ http://purl.uniprot.org/uniprot/G1KSE2 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/28377:LOC100556950 ^@ http://purl.uniprot.org/uniprot/G1KM71 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:srd5a2 ^@ http://purl.uniprot.org/uniprot/A0A803U1D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane http://togogenome.org/gene/28377:gabbr1 ^@ http://purl.uniprot.org/uniprot/G1KKP4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:LOC100566860 ^@ http://purl.uniprot.org/uniprot/A0A803TER0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Basal cell membrane|||Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Interacts with PDZK1. http://togogenome.org/gene/28377:smc1b ^@ http://purl.uniprot.org/uniprot/A0A803SKT6|||http://purl.uniprot.org/uniprot/A0A803T669|||http://purl.uniprot.org/uniprot/G1KQI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/28377:vdac1 ^@ http://purl.uniprot.org/uniprot/G1KB85 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/28377:tp53bp2 ^@ http://purl.uniprot.org/uniprot/G1KC53 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:slc34a1 ^@ http://purl.uniprot.org/uniprot/G1KFC5 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:syn3 ^@ http://purl.uniprot.org/uniprot/A0A803TIJ2 ^@ Similarity ^@ Belongs to the synapsin family. http://togogenome.org/gene/28377:dusp7 ^@ http://purl.uniprot.org/uniprot/G1KFU8 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/28377:areg ^@ http://purl.uniprot.org/uniprot/R4GAL3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:snx25 ^@ http://purl.uniprot.org/uniprot/G1KAI8 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/28377:ccdc130 ^@ http://purl.uniprot.org/uniprot/G1KIL0 ^@ Similarity ^@ Belongs to the CWC16 family. http://togogenome.org/gene/28377:mid1 ^@ http://purl.uniprot.org/uniprot/G1K9B6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ohanin/vespryn family.|||Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal.|||cytoskeleton http://togogenome.org/gene/28377:aim1 ^@ http://purl.uniprot.org/uniprot/G1KEG6 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/28377:xrcc3 ^@ http://purl.uniprot.org/uniprot/G1KKH6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Cytoplasm|||Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.|||Nucleus http://togogenome.org/gene/28377:sars ^@ http://purl.uniprot.org/uniprot/G1KK14 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. http://togogenome.org/gene/28377:rngtt ^@ http://purl.uniprot.org/uniprot/G1KQB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.|||In the C-terminal section; belongs to the eukaryotic GTase family.|||In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.|||Nucleus http://togogenome.org/gene/28377:LOC100566990 ^@ http://purl.uniprot.org/uniprot/A0A803T2J5 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. FIG1 subfamily. http://togogenome.org/gene/28377:LOC100552377 ^@ http://purl.uniprot.org/uniprot/A0A803T3I0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:cygb ^@ http://purl.uniprot.org/uniprot/A0A803TN90 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/28377:LOC100567926 ^@ http://purl.uniprot.org/uniprot/H9GS66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Membrane|||Microsome membrane http://togogenome.org/gene/28377:podxl2 ^@ http://purl.uniprot.org/uniprot/G1KGK8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:ripply2 ^@ http://purl.uniprot.org/uniprot/A0A803TKI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ripply family.|||Nucleus http://togogenome.org/gene/28377:kif6 ^@ http://purl.uniprot.org/uniprot/G1KAC6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/28377:LOC100553181 ^@ http://purl.uniprot.org/uniprot/G1KBV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/28377:galnt11 ^@ http://purl.uniprot.org/uniprot/G1KPK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:dnm1l ^@ http://purl.uniprot.org/uniprot/A0A803T7M5|||http://purl.uniprot.org/uniprot/G1KMD1 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/28377:hpdl ^@ http://purl.uniprot.org/uniprot/A0A803STW3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 4HPPD family.|||Binds 1 Fe cation per subunit.|||Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/28377:atp5j ^@ http://purl.uniprot.org/uniprot/G1KQE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ATPase subunit F6 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/28377:hmx3 ^@ http://purl.uniprot.org/uniprot/G1KU04 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:cry2 ^@ http://purl.uniprot.org/uniprot/G1KQ76 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/28377:LOC100567189 ^@ http://purl.uniprot.org/uniprot/R4GD21 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. FIG1 subfamily. http://togogenome.org/gene/28377:letmd1 ^@ http://purl.uniprot.org/uniprot/G1KV41 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/28377:foxi1 ^@ http://purl.uniprot.org/uniprot/G1KRV9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:gabra6 ^@ http://purl.uniprot.org/uniprot/G1KQN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/28377:lhfpl2 ^@ http://purl.uniprot.org/uniprot/G1KMG6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:grk6 ^@ http://purl.uniprot.org/uniprot/A0A803TNB1|||http://purl.uniprot.org/uniprot/G1KF64 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/28377:wnk4 ^@ http://purl.uniprot.org/uniprot/G1KPB8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/28377:nln ^@ http://purl.uniprot.org/uniprot/G1KRY5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/28377:fam150b ^@ http://purl.uniprot.org/uniprot/G1KE11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALKAL family.|||Secreted http://togogenome.org/gene/28377:lxn ^@ http://purl.uniprot.org/uniprot/G1KFW7 ^@ Similarity ^@ Belongs to the protease inhibitor I47 (latexin) family. http://togogenome.org/gene/28377:esr2 ^@ http://purl.uniprot.org/uniprot/G1KRR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/28377:uba5 ^@ http://purl.uniprot.org/uniprot/G1K8M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.|||Golgi apparatus http://togogenome.org/gene/28377:ext2 ^@ http://purl.uniprot.org/uniprot/G1KPS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/28377:rbm6 ^@ http://purl.uniprot.org/uniprot/G1KHX7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:ebna1bp2 ^@ http://purl.uniprot.org/uniprot/G1KNE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP2 family.|||Required for the processing of the 27S pre-rRNA.|||nucleolus http://togogenome.org/gene/28377:amigo3 ^@ http://purl.uniprot.org/uniprot/G1KGZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/28377:LOC100562622 ^@ http://purl.uniprot.org/uniprot/R4G9J2 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/28377:alas1 ^@ http://purl.uniprot.org/uniprot/G1KFQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/28377:llgl2 ^@ http://purl.uniprot.org/uniprot/G1KFR8 ^@ Similarity ^@ Belongs to the WD repeat L(2)GL family. http://togogenome.org/gene/28377:irak4 ^@ http://purl.uniprot.org/uniprot/G1KBF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.|||Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Cytoplasm|||Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. http://togogenome.org/gene/28377:cwf19l2 ^@ http://purl.uniprot.org/uniprot/A0A803TZM6|||http://purl.uniprot.org/uniprot/G1KKR3 ^@ Similarity ^@ Belongs to the CWF19 family. http://togogenome.org/gene/28377:LOC100565773 ^@ http://purl.uniprot.org/uniprot/A0A803T7V3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:tom1 ^@ http://purl.uniprot.org/uniprot/G1KX91 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/28377:hoxc6 ^@ http://purl.uniprot.org/uniprot/G1KKM7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:tctn2 ^@ http://purl.uniprot.org/uniprot/A0A803TX16 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/28377:gria4 ^@ http://purl.uniprot.org/uniprot/G1KLJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/28377:LOC100559642 ^@ http://purl.uniprot.org/uniprot/G1KIT2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:serp1 ^@ http://purl.uniprot.org/uniprot/A0A803SVU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAMP4 family.|||Endoplasmic reticulum membrane|||May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.|||Membrane http://togogenome.org/gene/28377:st3gal1 ^@ http://purl.uniprot.org/uniprot/G1KLN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/28377:akt1 ^@ http://purl.uniprot.org/uniprot/G1KLB6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/28377:gnpda2 ^@ http://purl.uniprot.org/uniprot/G1KG22 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/28377:mturn ^@ http://purl.uniprot.org/uniprot/A0A803TQA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MTURN family.|||Cytoplasm http://togogenome.org/gene/28377:cdc42bpa ^@ http://purl.uniprot.org/uniprot/G1KFT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.|||lamellipodium http://togogenome.org/gene/28377:slc6a1 ^@ http://purl.uniprot.org/uniprot/G1KJU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/28377:s1pr3 ^@ http://purl.uniprot.org/uniprot/G1KSQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100560181 ^@ http://purl.uniprot.org/uniprot/G1KMP9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/28377:gmpr ^@ http://purl.uniprot.org/uniprot/G1KCB8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/28377:atp6v0a1 ^@ http://purl.uniprot.org/uniprot/A0A803SPA5|||http://purl.uniprot.org/uniprot/G1KUJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/28377:mfsd1 ^@ http://purl.uniprot.org/uniprot/G1KFY4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:ephb1 ^@ http://purl.uniprot.org/uniprot/G1KIZ8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||dendrite http://togogenome.org/gene/28377:LOC100559198 ^@ http://purl.uniprot.org/uniprot/G1KBJ5 ^@ Function|||Similarity ^@ Belongs to the IPP isomerase type 1 family.|||Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/28377:fam168b ^@ http://purl.uniprot.org/uniprot/G1KDB1 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/28377:sugt1 ^@ http://purl.uniprot.org/uniprot/G1K8M8 ^@ Similarity ^@ Belongs to the SGT1 family. http://togogenome.org/gene/28377:serpine2 ^@ http://purl.uniprot.org/uniprot/G1KCT2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/28377:pdgfd ^@ http://purl.uniprot.org/uniprot/G1KLM4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:spopl ^@ http://purl.uniprot.org/uniprot/G1K8H7 ^@ Similarity ^@ Belongs to the Tdpoz family. http://togogenome.org/gene/28377:alx1 ^@ http://purl.uniprot.org/uniprot/G1KKV3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:kiaa0391 ^@ http://purl.uniprot.org/uniprot/G1KA25 ^@ Similarity ^@ Belongs to the PPR family. P subfamily. http://togogenome.org/gene/28377:wnt1 ^@ http://purl.uniprot.org/uniprot/A0A803TJF1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/28377:tdp1 ^@ http://purl.uniprot.org/uniprot/A0A803SNZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosyl-DNA phosphodiesterase family.|||Nucleus http://togogenome.org/gene/28377:clec11a ^@ http://purl.uniprot.org/uniprot/G1KLV3 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/28377:sumf1 ^@ http://purl.uniprot.org/uniprot/G1KJZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase-modifying factor family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/28377:enpp1 ^@ http://purl.uniprot.org/uniprot/G1K9C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||Secreted http://togogenome.org/gene/28377:nfs1 ^@ http://purl.uniprot.org/uniprot/G1KFC2 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/28377:prss12 ^@ http://purl.uniprot.org/uniprot/G1KP66 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family. Snake venom subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.|||Secreted http://togogenome.org/gene/28377:tmem86a ^@ http://purl.uniprot.org/uniprot/G1K892 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/28377:rnaseh2b ^@ http://purl.uniprot.org/uniprot/G1KLE8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase H2 subunit B family.|||Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Nucleus|||The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C. http://togogenome.org/gene/28377:LOC100564129 ^@ http://purl.uniprot.org/uniprot/G1KFF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:mboat1 ^@ http://purl.uniprot.org/uniprot/G1KBL2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:LOC100558842 ^@ http://purl.uniprot.org/uniprot/A0A803TPR6|||http://purl.uniprot.org/uniprot/G1K916 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Homodimer.|||Homodimerization via the leucine zipper domains is required for autophosphorylation. http://togogenome.org/gene/28377:smarcd2 ^@ http://purl.uniprot.org/uniprot/G1KUI3 ^@ Similarity ^@ Belongs to the SMARCD family. http://togogenome.org/gene/28377:c3h11orf87 ^@ http://purl.uniprot.org/uniprot/G1KY40 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:tcf7 ^@ http://purl.uniprot.org/uniprot/A0A803TZW1|||http://purl.uniprot.org/uniprot/G1KB47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/28377:trappc11 ^@ http://purl.uniprot.org/uniprot/G1KBN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPPC11 family.|||Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.|||cis-Golgi network http://togogenome.org/gene/28377:dtymk ^@ http://purl.uniprot.org/uniprot/G1K8P8 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/28377:LOC100554736 ^@ http://purl.uniprot.org/uniprot/G1KN45 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/28377:LOC100567056 ^@ http://purl.uniprot.org/uniprot/G1KW15 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Basal cell membrane|||Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Interacts with PDZK1. http://togogenome.org/gene/28377:hdhd2 ^@ http://purl.uniprot.org/uniprot/A0A803SKK1 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/28377:cel ^@ http://purl.uniprot.org/uniprot/A0A803TGI9|||http://purl.uniprot.org/uniprot/G1KDB8 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/28377:fam189a2 ^@ http://purl.uniprot.org/uniprot/G1K974 ^@ Similarity ^@ Belongs to the ENTREP family. http://togogenome.org/gene/28377:tmtc1 ^@ http://purl.uniprot.org/uniprot/G1KN82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/28377:LOC103278592 ^@ http://purl.uniprot.org/uniprot/A0A803U1A2 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/28377:sec61g ^@ http://purl.uniprot.org/uniprot/A0A803SRE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:galr3 ^@ http://purl.uniprot.org/uniprot/A0A803T956 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/28377:LOC100559926 ^@ http://purl.uniprot.org/uniprot/G1KBT3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. http://togogenome.org/gene/28377:chst1 ^@ http://purl.uniprot.org/uniprot/G1KQ31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/28377:gatb ^@ http://purl.uniprot.org/uniprot/G1KB84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/28377:irf3 ^@ http://purl.uniprot.org/uniprot/A0A0X7YTM9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:tmem135 ^@ http://purl.uniprot.org/uniprot/A0A803T9V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM135 family.|||Membrane http://togogenome.org/gene/28377:actr3b ^@ http://purl.uniprot.org/uniprot/G1KKF5 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/28377:cacna2d1 ^@ http://purl.uniprot.org/uniprot/G1KNB8 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/28377:btf3l4 ^@ http://purl.uniprot.org/uniprot/A0A803TWR6 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/28377:nsun3 ^@ http://purl.uniprot.org/uniprot/G1K8I3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/28377:tmeff2 ^@ http://purl.uniprot.org/uniprot/G1KFP7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:gpr17 ^@ http://purl.uniprot.org/uniprot/G1KE19 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:tprkb ^@ http://purl.uniprot.org/uniprot/A0A803T344 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/28377:ddx41 ^@ http://purl.uniprot.org/uniprot/G1KES9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX41 subfamily. http://togogenome.org/gene/28377:gad2 ^@ http://purl.uniprot.org/uniprot/G1KHN1 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/28377:ndufaf1 ^@ http://purl.uniprot.org/uniprot/G1KXZ2 ^@ Function|||Similarity ^@ As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the CIA30 family. http://togogenome.org/gene/28377:rpl37 ^@ http://purl.uniprot.org/uniprot/A0A803TIH1 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/28377:ormdl3 ^@ http://purl.uniprot.org/uniprot/G1KBQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/28377:nit2 ^@ http://purl.uniprot.org/uniprot/G1KL30 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/28377:LOC100555397 ^@ http://purl.uniprot.org/uniprot/G1KQP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/28377:egf ^@ http://purl.uniprot.org/uniprot/A0A803SNT5|||http://purl.uniprot.org/uniprot/A0A803SU34|||http://purl.uniprot.org/uniprot/A0A803TYV4|||http://purl.uniprot.org/uniprot/G1KJV5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:prss35 ^@ http://purl.uniprot.org/uniprot/G1KCP3 ^@ Similarity ^@ Belongs to the peptidase S1 family. Snake venom subfamily. http://togogenome.org/gene/28377:gja1 ^@ http://purl.uniprot.org/uniprot/G1KZB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/28377:galnt1 ^@ http://purl.uniprot.org/uniprot/G1KFW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:nr1d1 ^@ http://purl.uniprot.org/uniprot/G1KB93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/28377:vsx1 ^@ http://purl.uniprot.org/uniprot/G1KP43 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:LOC100553182 ^@ http://purl.uniprot.org/uniprot/G1KNZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/28377:ergic1 ^@ http://purl.uniprot.org/uniprot/A0A803TG51|||http://purl.uniprot.org/uniprot/G1KQV2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/28377:itfg1 ^@ http://purl.uniprot.org/uniprot/H9GKF2 ^@ Similarity ^@ Belongs to the TIP family. http://togogenome.org/gene/28377:dazap2 ^@ http://purl.uniprot.org/uniprot/G1KM01 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus speckle|||nuclear body http://togogenome.org/gene/28377:tecr ^@ http://purl.uniprot.org/uniprot/G1KTG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:LOC100557814 ^@ http://purl.uniprot.org/uniprot/A0A803SQC0|||http://purl.uniprot.org/uniprot/G1KBH3 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/28377:ndufa5 ^@ http://purl.uniprot.org/uniprot/A0A803TFZ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/28377:tcp11l2 ^@ http://purl.uniprot.org/uniprot/G1KR74 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/28377:tbl1xr1 ^@ http://purl.uniprot.org/uniprot/A0A803TZ34|||http://purl.uniprot.org/uniprot/G1KNU8 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/28377:arhgef7 ^@ http://purl.uniprot.org/uniprot/A0A803T6B1|||http://purl.uniprot.org/uniprot/G1KF97 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/28377:fam58a ^@ http://purl.uniprot.org/uniprot/G1KIK6 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin-like FAM58 subfamily. http://togogenome.org/gene/28377:ybey ^@ http://purl.uniprot.org/uniprot/G1KDH9 ^@ Similarity ^@ Belongs to the endoribonuclease YbeY family. http://togogenome.org/gene/28377:sept11 ^@ http://purl.uniprot.org/uniprot/A0A803SXX3 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/28377:tram2 ^@ http://purl.uniprot.org/uniprot/G1KDK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/28377:LOC100555978 ^@ http://purl.uniprot.org/uniprot/G1KUS3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/28377:trip13 ^@ http://purl.uniprot.org/uniprot/G1KIT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. PCH2 subfamily.|||Nucleus|||Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. http://togogenome.org/gene/28377:rpl24 ^@ http://purl.uniprot.org/uniprot/G1KLR6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/28377:rpap1 ^@ http://purl.uniprot.org/uniprot/G1KPH2 ^@ Similarity ^@ Belongs to the RPAP1 family. http://togogenome.org/gene/28377:impa1 ^@ http://purl.uniprot.org/uniprot/G1KP58 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/28377:LOC100554096 ^@ http://purl.uniprot.org/uniprot/G1KGZ5 ^@ Similarity ^@ Belongs to the SelWTH family. Selenoprotein T subfamily. http://togogenome.org/gene/28377:pxmp4 ^@ http://purl.uniprot.org/uniprot/A0A803SLS7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Interacts with PEX19.|||Peroxisome membrane http://togogenome.org/gene/28377:gria2 ^@ http://purl.uniprot.org/uniprot/A0A803SWT9|||http://purl.uniprot.org/uniprot/A0A803TZZ9|||http://purl.uniprot.org/uniprot/G1KT27 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/28377:LOC100554738 ^@ http://purl.uniprot.org/uniprot/G1KJN3 ^@ Similarity ^@ Belongs to the transferrin family. http://togogenome.org/gene/28377:eya2 ^@ http://purl.uniprot.org/uniprot/G1KSX3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/28377:pkn2 ^@ http://purl.uniprot.org/uniprot/G1K9M8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cleavage furrow|||Midbody|||Nucleus http://togogenome.org/gene/28377:meox2 ^@ http://purl.uniprot.org/uniprot/G1KMW8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:impact ^@ http://purl.uniprot.org/uniprot/G1K9U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IMPACT family.|||Cytoplasm http://togogenome.org/gene/28377:itgb7 ^@ http://purl.uniprot.org/uniprot/G1KFZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100563926 ^@ http://purl.uniprot.org/uniprot/G1KSQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/28377:plcd1 ^@ http://purl.uniprot.org/uniprot/A0A803T1M3|||http://purl.uniprot.org/uniprot/G1KDV8 ^@ Cofactor ^@ Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. http://togogenome.org/gene/28377:kcnq1 ^@ http://purl.uniprot.org/uniprot/A0A803SQK8|||http://purl.uniprot.org/uniprot/R4GA42 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Endoplasmic reticulum|||Lateral cell membrane|||Membrane|||Membrane raft http://togogenome.org/gene/28377:galnt2 ^@ http://purl.uniprot.org/uniprot/G1K9H8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:abcb1 ^@ http://purl.uniprot.org/uniprot/G1KSF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:cks2 ^@ http://purl.uniprot.org/uniprot/G1KSS8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/28377:ube2k ^@ http://purl.uniprot.org/uniprot/G1KL25 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/28377:maml2 ^@ http://purl.uniprot.org/uniprot/G1KNX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mastermind family.|||Nucleus speckle http://togogenome.org/gene/28377:ero1b ^@ http://purl.uniprot.org/uniprot/G1KAL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/28377:steap1 ^@ http://purl.uniprot.org/uniprot/G1KRU2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:dph2 ^@ http://purl.uniprot.org/uniprot/G1KPS5 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family. DPH2 subfamily.|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit. http://togogenome.org/gene/28377:cpq ^@ http://purl.uniprot.org/uniprot/G1KCR8 ^@ Subcellular Location Annotation|||Subunit ^@ Endoplasmic reticulum|||Golgi apparatus|||Homodimer. The monomeric form is inactive while the homodimer is active.|||Lysosome http://togogenome.org/gene/28377:rbm5 ^@ http://purl.uniprot.org/uniprot/G1KI28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBM5/RBM10 family.|||Nucleus http://togogenome.org/gene/28377:ism1 ^@ http://purl.uniprot.org/uniprot/G1K920 ^@ Similarity ^@ Belongs to the isthmin family. http://togogenome.org/gene/28377:eef1akmt1 ^@ http://purl.uniprot.org/uniprot/A0A803SRA0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.|||Cytoplasm|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.|||Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure. http://togogenome.org/gene/28377:slc6a9 ^@ http://purl.uniprot.org/uniprot/G1KQ50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100563580 ^@ http://purl.uniprot.org/uniprot/G1KUQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM151 family.|||Membrane http://togogenome.org/gene/28377:LOC100566604 ^@ http://purl.uniprot.org/uniprot/G1KLP5 ^@ Function|||Similarity ^@ Belongs to the ohanin/vespryn family.|||Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal. http://togogenome.org/gene/28377:LOC100556109 ^@ http://purl.uniprot.org/uniprot/G1KMA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Melanosome|||Membrane|||SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/28377:hdac4 ^@ http://purl.uniprot.org/uniprot/A0A803T4T9|||http://purl.uniprot.org/uniprot/A0A803T8I1|||http://purl.uniprot.org/uniprot/G1KJ78 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. http://togogenome.org/gene/28377:dph6 ^@ http://purl.uniprot.org/uniprot/A0A803TXM5|||http://purl.uniprot.org/uniprot/R4G926 ^@ Similarity ^@ Belongs to the Diphthine--ammonia ligase family. http://togogenome.org/gene/28377:usp9x ^@ http://purl.uniprot.org/uniprot/G1KUK4 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/28377:gpr20 ^@ http://purl.uniprot.org/uniprot/G1K8N8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:mrps10 ^@ http://purl.uniprot.org/uniprot/G1K988 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS10 family.|||Mitochondrion http://togogenome.org/gene/28377:mrps18b ^@ http://purl.uniprot.org/uniprot/A0A803SQW3|||http://purl.uniprot.org/uniprot/A0A803U087 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily. http://togogenome.org/gene/28377:gpr89b ^@ http://purl.uniprot.org/uniprot/G1KPD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Golgi pH regulator (TC 1.A.38) family.|||Membrane http://togogenome.org/gene/28377:cmas ^@ http://purl.uniprot.org/uniprot/A0A803STF5|||http://purl.uniprot.org/uniprot/G1KTP0 ^@ Similarity ^@ Belongs to the CMP-NeuNAc synthase family. http://togogenome.org/gene/28377:LOC100558791 ^@ http://purl.uniprot.org/uniprot/G1KFN5 ^@ Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 56 family.|||Monomer. http://togogenome.org/gene/28377:baz2a ^@ http://purl.uniprot.org/uniprot/G1KT13 ^@ Similarity ^@ Belongs to the WAL family. http://togogenome.org/gene/28377:camk2d ^@ http://purl.uniprot.org/uniprot/A0A803SS99|||http://purl.uniprot.org/uniprot/A0A803SX49|||http://purl.uniprot.org/uniprot/A0A803TV78|||http://purl.uniprot.org/uniprot/L7MZX9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/28377:pik3r1 ^@ http://purl.uniprot.org/uniprot/A0A803TIM1|||http://purl.uniprot.org/uniprot/G1KSH1|||http://purl.uniprot.org/uniprot/R4GAH3 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/28377:nfx1 ^@ http://purl.uniprot.org/uniprot/G1KAY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NFX1 family.|||Nucleus http://togogenome.org/gene/28377:pou2f1 ^@ http://purl.uniprot.org/uniprot/A0A803THI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-2 subfamily.|||Nucleus http://togogenome.org/gene/28377:LOC100554601 ^@ http://purl.uniprot.org/uniprot/L7MZF7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:slc1a4 ^@ http://purl.uniprot.org/uniprot/G1K9W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/28377:tef ^@ http://purl.uniprot.org/uniprot/A0A803TMH8|||http://purl.uniprot.org/uniprot/G1KD66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/28377:gabrg2 ^@ http://purl.uniprot.org/uniprot/A0A803SWE3|||http://purl.uniprot.org/uniprot/G1KQE5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/28377:sephs1 ^@ http://purl.uniprot.org/uniprot/G1K913 ^@ Function ^@ Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/28377:kcna10 ^@ http://purl.uniprot.org/uniprot/G1KRX8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:LOC100565285 ^@ http://purl.uniprot.org/uniprot/R4G9Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MPEG1 family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/28377:kif19 ^@ http://purl.uniprot.org/uniprot/G1KQL0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/28377:LOC100562946 ^@ http://purl.uniprot.org/uniprot/G1KEI6 ^@ Similarity ^@ Belongs to the CBP3 family. http://togogenome.org/gene/28377:lancl1 ^@ http://purl.uniprot.org/uniprot/G1KKC6 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/28377:gpr37l1 ^@ http://purl.uniprot.org/uniprot/A0A803T793 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/28377:cebpz ^@ http://purl.uniprot.org/uniprot/G1K9H6 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/28377:pdgfrb ^@ http://purl.uniprot.org/uniprot/G1KR75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:ldlrad4 ^@ http://purl.uniprot.org/uniprot/A0A803SSM4|||http://purl.uniprot.org/uniprot/A0A803TEE7|||http://purl.uniprot.org/uniprot/G1KND0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMEPA1 family.|||Early endosome membrane|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:utp23 ^@ http://purl.uniprot.org/uniprot/A0A803TDQ7 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/28377:htr1e ^@ http://purl.uniprot.org/uniprot/G1KQU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100561221 ^@ http://purl.uniprot.org/uniprot/R4GDB1 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/28377:cenpl ^@ http://purl.uniprot.org/uniprot/G1KR38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-L/IML3 family.|||Nucleus http://togogenome.org/gene/28377:hif1a ^@ http://purl.uniprot.org/uniprot/G1KSA4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/28377:mfsd6 ^@ http://purl.uniprot.org/uniprot/A0A803TA43|||http://purl.uniprot.org/uniprot/G1K8S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. MFSD6 family.|||Membrane http://togogenome.org/gene/28377:snx11 ^@ http://purl.uniprot.org/uniprot/G1KFI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/28377:nol12 ^@ http://purl.uniprot.org/uniprot/G1KR91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP17 family.|||nucleolus http://togogenome.org/gene/28377:birc2 ^@ http://purl.uniprot.org/uniprot/G1KMP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:armc8 ^@ http://purl.uniprot.org/uniprot/G1KGB2 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/28377:atp8a1 ^@ http://purl.uniprot.org/uniprot/G1KGP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/28377:LOC100555911 ^@ http://purl.uniprot.org/uniprot/G1KF88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100553034 ^@ http://purl.uniprot.org/uniprot/G1KYB1 ^@ Function|||Similarity ^@ Belongs to the ficolin lectin family. Veficolin subfamily.|||Initiates complement activation and/or interferes in platelet aggregation and/or blood coagulation. http://togogenome.org/gene/28377:cntf ^@ http://purl.uniprot.org/uniprot/G1KFR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNTF family.|||CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.|||Cytoplasm http://togogenome.org/gene/28377:mmp2 ^@ http://purl.uniprot.org/uniprot/H9GNC8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||extracellular matrix http://togogenome.org/gene/28377:LOC100555417 ^@ http://purl.uniprot.org/uniprot/G1KUJ2 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/28377:pcnx2 ^@ http://purl.uniprot.org/uniprot/G1K8X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/28377:nsf ^@ http://purl.uniprot.org/uniprot/A0A803SW71|||http://purl.uniprot.org/uniprot/G1KSV2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. http://togogenome.org/gene/28377:nrxn3 ^@ http://purl.uniprot.org/uniprot/G1KTT1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:LOC100553037 ^@ http://purl.uniprot.org/uniprot/R4GBV1 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/28377:smpd2 ^@ http://purl.uniprot.org/uniprot/A0A803TWA1|||http://purl.uniprot.org/uniprot/G1KIQ0 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/28377:gpr37 ^@ http://purl.uniprot.org/uniprot/G1K991 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/28377:ldha ^@ http://purl.uniprot.org/uniprot/G1K888 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/28377:fam162b ^@ http://purl.uniprot.org/uniprot/A0A803STD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0389 family.|||Membrane http://togogenome.org/gene/28377:dock10 ^@ http://purl.uniprot.org/uniprot/A0A803TTX4|||http://purl.uniprot.org/uniprot/G1KCG2|||http://purl.uniprot.org/uniprot/R4GCF5 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/28377:nosip ^@ http://purl.uniprot.org/uniprot/G1KPB9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOSIP family.|||Cytoplasm|||Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity.|||Nucleus http://togogenome.org/gene/28377:mtrf1l ^@ http://purl.uniprot.org/uniprot/G1KED9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/28377:cep63 ^@ http://purl.uniprot.org/uniprot/G1KJ28 ^@ Similarity ^@ Belongs to the CEP63 family. http://togogenome.org/gene/28377:gmppa ^@ http://purl.uniprot.org/uniprot/A0A803SV96|||http://purl.uniprot.org/uniprot/G1KPI0 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/28377:sae1 ^@ http://purl.uniprot.org/uniprot/A0A803TQ31 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/28377:slc17a6 ^@ http://purl.uniprot.org/uniprot/G1KQR9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:dock6 ^@ http://purl.uniprot.org/uniprot/G1KT35 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/28377:cga ^@ http://purl.uniprot.org/uniprot/A0A803SMK5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Heterodimer of an alpha and a beta chain.|||Secreted http://togogenome.org/gene/28377:st7l ^@ http://purl.uniprot.org/uniprot/G1KUJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/28377:mkx ^@ http://purl.uniprot.org/uniprot/G1KH38 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:dync1li1 ^@ http://purl.uniprot.org/uniprot/G1KQ93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.|||Belongs to the dynein light intermediate chain family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).|||cytoskeleton http://togogenome.org/gene/28377:LOC100559860 ^@ http://purl.uniprot.org/uniprot/G1KST0 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/28377:mboat2 ^@ http://purl.uniprot.org/uniprot/G1KAL2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:foxp4 ^@ http://purl.uniprot.org/uniprot/A0A803STZ0|||http://purl.uniprot.org/uniprot/G1KAZ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:acy1 ^@ http://purl.uniprot.org/uniprot/G1KLT2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Binds 2 Zn(2+) ions per subunit.|||Cytoplasm http://togogenome.org/gene/28377:c2h19orf53 ^@ http://purl.uniprot.org/uniprot/G1KIL8 ^@ Similarity ^@ Belongs to the UPF0390 family. http://togogenome.org/gene/28377:nnt ^@ http://purl.uniprot.org/uniprot/A0A803TAX5 ^@ Similarity ^@ In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/28377:slc25a26 ^@ http://purl.uniprot.org/uniprot/G1KAQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/28377:elf3 ^@ http://purl.uniprot.org/uniprot/A0A803TFP0|||http://purl.uniprot.org/uniprot/G1KCK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/28377:dse ^@ http://purl.uniprot.org/uniprot/G1KP68 ^@ Similarity ^@ Belongs to the dermatan-sulfate isomerase family. http://togogenome.org/gene/28377:htra1 ^@ http://purl.uniprot.org/uniprot/A0A803T192 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/28377:fgfbp2 ^@ http://purl.uniprot.org/uniprot/G1KM24 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/28377:polr3f ^@ http://purl.uniprot.org/uniprot/G1KPS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/28377:mical1 ^@ http://purl.uniprot.org/uniprot/G1KIU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mical family.|||Belongs to the flavin monoamine oxidase family. FIG1 subfamily.|||Cytoplasm http://togogenome.org/gene/28377:acat2 ^@ http://purl.uniprot.org/uniprot/G1KCU1 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/28377:tmtc3 ^@ http://purl.uniprot.org/uniprot/G1KLD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/28377:elp4 ^@ http://purl.uniprot.org/uniprot/G1KAE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:mnd1 ^@ http://purl.uniprot.org/uniprot/A0A803T3K4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MND1 family.|||Nucleus|||Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. http://togogenome.org/gene/28377:acox2 ^@ http://purl.uniprot.org/uniprot/G1KLB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/28377:LOC100565764 ^@ http://purl.uniprot.org/uniprot/G1K9M5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selectin/LECAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/28377:LOC100559794 ^@ http://purl.uniprot.org/uniprot/R4GBW2 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/28377:pros1 ^@ http://purl.uniprot.org/uniprot/G1K8T9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:LOC100552727 ^@ http://purl.uniprot.org/uniprot/A0A803TR14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/28377:LOC100555193 ^@ http://purl.uniprot.org/uniprot/A0A803T988 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/28377:dcp1a ^@ http://purl.uniprot.org/uniprot/G1KKS9 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/28377:gart ^@ http://purl.uniprot.org/uniprot/A0A803SP58 ^@ Similarity ^@ In the C-terminal section; belongs to the GART family.|||In the N-terminal section; belongs to the GARS family.|||In the central section; belongs to the AIR synthase family. http://togogenome.org/gene/28377:syndig1l ^@ http://purl.uniprot.org/uniprot/G1KSM4 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/28377:map3k13 ^@ http://purl.uniprot.org/uniprot/G1KH56 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/28377:LOC100557683 ^@ http://purl.uniprot.org/uniprot/A0A803SPS6 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/28377:LOC100553301 ^@ http://purl.uniprot.org/uniprot/G1KHG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/28377:LOC100337545 ^@ http://purl.uniprot.org/uniprot/B6Z1W5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:rnaset2 ^@ http://purl.uniprot.org/uniprot/G1KK73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase T2 family.|||Lysosome lumen http://togogenome.org/gene/28377:pdia6 ^@ http://purl.uniprot.org/uniprot/G1KN70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen|||Melanosome http://togogenome.org/gene/28377:LOC100563157 ^@ http://purl.uniprot.org/uniprot/L7MZV0 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||RNA-binding protein that regulates alternative splicing events. http://togogenome.org/gene/28377:dock3 ^@ http://purl.uniprot.org/uniprot/G1KGW0 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/28377:gpbp1 ^@ http://purl.uniprot.org/uniprot/G1KQ33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/28377:LOC100557236 ^@ http://purl.uniprot.org/uniprot/A0A803STF3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/28377:p4ha2 ^@ http://purl.uniprot.org/uniprot/A0A803SW13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/28377:adam8 ^@ http://purl.uniprot.org/uniprot/G1KTY5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:foxi3 ^@ http://purl.uniprot.org/uniprot/G1KGL5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:lnpep ^@ http://purl.uniprot.org/uniprot/G1KM27 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/28377:rsbn1 ^@ http://purl.uniprot.org/uniprot/G1K8C1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the round spermatid basic protein 1 family.|||Nucleus http://togogenome.org/gene/28377:ccna1 ^@ http://purl.uniprot.org/uniprot/A0A803SQ41|||http://purl.uniprot.org/uniprot/G1KCT3 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily. http://togogenome.org/gene/28377:bbs7 ^@ http://purl.uniprot.org/uniprot/G1KMJ2 ^@ Function|||Subunit ^@ Part of BBSome complex.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. http://togogenome.org/gene/28377:slco4a1 ^@ http://purl.uniprot.org/uniprot/G1KDM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100557806 ^@ http://purl.uniprot.org/uniprot/A0A803SV69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/28377:psme3 ^@ http://purl.uniprot.org/uniprot/G1KP54 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/28377:slc15a1 ^@ http://purl.uniprot.org/uniprot/A0A803T6J5|||http://purl.uniprot.org/uniprot/G1KST4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/28377:adcyap1 ^@ http://purl.uniprot.org/uniprot/A0A803TVX1|||http://purl.uniprot.org/uniprot/G1KI35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/28377:rad54l2 ^@ http://purl.uniprot.org/uniprot/G1KRR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/28377:klhl15 ^@ http://purl.uniprot.org/uniprot/G1KGI5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:ints10 ^@ http://purl.uniprot.org/uniprot/A0A803SZM5|||http://purl.uniprot.org/uniprot/G1KII5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 10 family.|||Nucleus http://togogenome.org/gene/28377:ndufb9 ^@ http://purl.uniprot.org/uniprot/G1KJK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/28377:erap1 ^@ http://purl.uniprot.org/uniprot/G1KMG9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/28377:ebag9 ^@ http://purl.uniprot.org/uniprot/G1KAT9 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. http://togogenome.org/gene/28377:LOC100566596 ^@ http://purl.uniprot.org/uniprot/A0A803TPU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:LOC100555135 ^@ http://purl.uniprot.org/uniprot/G1KNY3 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/28377:tbca ^@ http://purl.uniprot.org/uniprot/A0A803TYV9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCA family.|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.|||Tubulin-folding protein; involved in the early step of the tubulin folding pathway.|||cytoskeleton http://togogenome.org/gene/28377:kcnh8 ^@ http://purl.uniprot.org/uniprot/A0A803TVZ9|||http://purl.uniprot.org/uniprot/G1K854 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/28377:yeats2 ^@ http://purl.uniprot.org/uniprot/G1KD41 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:cpne3 ^@ http://purl.uniprot.org/uniprot/G1KJN5 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/28377:tk1 ^@ http://purl.uniprot.org/uniprot/C3VAL3|||http://purl.uniprot.org/uniprot/G1KT08 ^@ Similarity ^@ Belongs to the thymidine kinase family. http://togogenome.org/gene/28377:klc1 ^@ http://purl.uniprot.org/uniprot/G1KKG6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/28377:bsn ^@ http://purl.uniprot.org/uniprot/G1KVM6 ^@ Subcellular Location Annotation ^@ Presynaptic active zone http://togogenome.org/gene/28377:chrm5 ^@ http://purl.uniprot.org/uniprot/G1KXM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/28377:b3galnt1 ^@ http://purl.uniprot.org/uniprot/G1KGE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:map3k9 ^@ http://purl.uniprot.org/uniprot/A0A803SVK2|||http://purl.uniprot.org/uniprot/G1KDB6 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Homodimer.|||Homodimerization via the leucine zipper domains is required for autophosphorylation. http://togogenome.org/gene/28377:pacsin1 ^@ http://purl.uniprot.org/uniprot/G1KRR6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Cell projection|||Cytoplasm|||Membrane http://togogenome.org/gene/28377:b3gnt8 ^@ http://purl.uniprot.org/uniprot/H9GQP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:gnpda1 ^@ http://purl.uniprot.org/uniprot/G1KNQ1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/28377:mfsd4b ^@ http://purl.uniprot.org/uniprot/G1KL55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:trmt6 ^@ http://purl.uniprot.org/uniprot/G1K8L7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM6/GCD10 family.|||Heterotetramer.|||Nucleus|||Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. http://togogenome.org/gene/28377:kif27 ^@ http://purl.uniprot.org/uniprot/G1K9W1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/28377:senp2 ^@ http://purl.uniprot.org/uniprot/A0A803T6U9 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/28377:elavl4 ^@ http://purl.uniprot.org/uniprot/G1KCV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm|||Perikaryon|||axon|||dendrite|||growth cone http://togogenome.org/gene/28377:ppef1 ^@ http://purl.uniprot.org/uniprot/G1KLG7 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/28377:panx1 ^@ http://purl.uniprot.org/uniprot/G1KPN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/28377:vrtn ^@ http://purl.uniprot.org/uniprot/G1KSL7 ^@ Similarity ^@ Belongs to the vertnin family. http://togogenome.org/gene/28377:kcnv2 ^@ http://purl.uniprot.org/uniprot/G1KBK6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:dars2 ^@ http://purl.uniprot.org/uniprot/R4G9Q0 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. http://togogenome.org/gene/28377:pkp1 ^@ http://purl.uniprot.org/uniprot/R4GBL1 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/28377:tmem18 ^@ http://purl.uniprot.org/uniprot/R4GCR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM18 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/28377:abca1 ^@ http://purl.uniprot.org/uniprot/G1KQ95 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:aadac ^@ http://purl.uniprot.org/uniprot/G1KH99 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/28377:magoh ^@ http://purl.uniprot.org/uniprot/G1KI51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/28377:aff4 ^@ http://purl.uniprot.org/uniprot/G1KV91 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/28377:cdk6 ^@ http://purl.uniprot.org/uniprot/G1KQY0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/28377:wisp1 ^@ http://purl.uniprot.org/uniprot/G1KLD0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:syt14 ^@ http://purl.uniprot.org/uniprot/A0A803TIR7 ^@ Similarity ^@ Belongs to the synaptotagmin family. http://togogenome.org/gene/28377:wfikkn2 ^@ http://purl.uniprot.org/uniprot/G1K9Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WFIKKN family.|||Secreted http://togogenome.org/gene/28377:mdfi ^@ http://purl.uniprot.org/uniprot/G1KAZ3 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/28377:tfdp1 ^@ http://purl.uniprot.org/uniprot/G1K8K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/28377:ipo13 ^@ http://purl.uniprot.org/uniprot/G1KPQ8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the importin beta family.|||Cytoplasm|||Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.|||Nucleus http://togogenome.org/gene/28377:mid1ip1 ^@ http://purl.uniprot.org/uniprot/G1KWB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:nkiras2 ^@ http://purl.uniprot.org/uniprot/A0A803T4N2|||http://purl.uniprot.org/uniprot/G1KTA9 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/28377:nsmce2 ^@ http://purl.uniprot.org/uniprot/G1KJZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NSE2 family.|||Nucleus http://togogenome.org/gene/28377:tmem91 ^@ http://purl.uniprot.org/uniprot/H9G821 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/28377:arl6ip4 ^@ http://purl.uniprot.org/uniprot/A0A803TQ49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARL6IP4 family.|||Nucleus speckle|||nucleolus http://togogenome.org/gene/28377:prss23 ^@ http://purl.uniprot.org/uniprot/G1KB22 ^@ Similarity ^@ Belongs to the peptidase S1 family. Snake venom subfamily. http://togogenome.org/gene/28377:cacnb2 ^@ http://purl.uniprot.org/uniprot/A0A803SZ96|||http://purl.uniprot.org/uniprot/G1KEE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||sarcolemma http://togogenome.org/gene/28377:gnb4 ^@ http://purl.uniprot.org/uniprot/G1KD23 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/28377:ube2f ^@ http://purl.uniprot.org/uniprot/A0A803U131 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/28377:yipf1 ^@ http://purl.uniprot.org/uniprot/G1KIB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Golgi apparatus membrane|||Late endosome membrane|||Membrane|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/28377:lhx4 ^@ http://purl.uniprot.org/uniprot/A0A803TUW7|||http://purl.uniprot.org/uniprot/G1K8W9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:cd82 ^@ http://purl.uniprot.org/uniprot/G1KPW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/28377:dcbld2 ^@ http://purl.uniprot.org/uniprot/G1KKS5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:kcnb2 ^@ http://purl.uniprot.org/uniprot/G1KYA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.|||Cell membrane|||Membrane|||Perikaryon|||dendrite http://togogenome.org/gene/28377:tmem263 ^@ http://purl.uniprot.org/uniprot/G1KX94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM263 family.|||Membrane http://togogenome.org/gene/28377:slc7a6 ^@ http://purl.uniprot.org/uniprot/H9GGF1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:kcnmb1 ^@ http://purl.uniprot.org/uniprot/R4GAN8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:hsdl2 ^@ http://purl.uniprot.org/uniprot/G1KTT6 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/28377:LOC100567055 ^@ http://purl.uniprot.org/uniprot/G1KHP6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:zdhhc23 ^@ http://purl.uniprot.org/uniprot/G1KV57 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/28377:fasn ^@ http://purl.uniprot.org/uniprot/G1KJG9 ^@ Function ^@ Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. http://togogenome.org/gene/28377:slc7a13 ^@ http://purl.uniprot.org/uniprot/G1KPC5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:LOC100565035 ^@ http://purl.uniprot.org/uniprot/A0A803TU23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/28377:bmp3 ^@ http://purl.uniprot.org/uniprot/G1KJS6 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/28377:prpf38a ^@ http://purl.uniprot.org/uniprot/G1KHK2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRP38 family.|||Component of the spliceosome B complex.|||Involved in pre-mRNA splicing as a component of the spliceosome.|||Nucleus http://togogenome.org/gene/28377:igfbp3 ^@ http://purl.uniprot.org/uniprot/A0A803TUV7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:gsto1 ^@ http://purl.uniprot.org/uniprot/G1KDR7 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/28377:nsun7 ^@ http://purl.uniprot.org/uniprot/G1KLL8 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:snw1 ^@ http://purl.uniprot.org/uniprot/G1KTQ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNW family.|||Identified in the spliceosome C complex.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/28377:ccdc107 ^@ http://purl.uniprot.org/uniprot/R4G995 ^@ Similarity ^@ Belongs to the ric-3 family. http://togogenome.org/gene/28377:skap1 ^@ http://purl.uniprot.org/uniprot/A0A803TUC9|||http://purl.uniprot.org/uniprot/G1KFG7 ^@ Similarity ^@ Belongs to the SKAP family. http://togogenome.org/gene/28377:ezr ^@ http://purl.uniprot.org/uniprot/G1KD48 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/28377:psmg2 ^@ http://purl.uniprot.org/uniprot/G1KNR3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PSMG2 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.|||Forms a heterodimer with PSMG1. http://togogenome.org/gene/28377:cab39 ^@ http://purl.uniprot.org/uniprot/G1KB07 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/28377:ccdc22 ^@ http://purl.uniprot.org/uniprot/G1KNU1 ^@ Similarity ^@ Belongs to the CCDC22 family. http://togogenome.org/gene/28377:eif5a2 ^@ http://purl.uniprot.org/uniprot/G1KS44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:adcy8 ^@ http://purl.uniprot.org/uniprot/A0A803TL20|||http://purl.uniprot.org/uniprot/G1KKD9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/28377:usp44 ^@ http://purl.uniprot.org/uniprot/G1KPI7 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/28377:pdcd4 ^@ http://purl.uniprot.org/uniprot/G1KRL9 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/28377:LOC100552978 ^@ http://purl.uniprot.org/uniprot/G1KUR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/28377:taf4b ^@ http://purl.uniprot.org/uniprot/G1KA85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF4 family.|||Nucleus http://togogenome.org/gene/28377:mis18a ^@ http://purl.uniprot.org/uniprot/G1KB64 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.|||centromere http://togogenome.org/gene/28377:dram1 ^@ http://purl.uniprot.org/uniprot/G1KSS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:mut ^@ http://purl.uniprot.org/uniprot/G1KMV1 ^@ Function|||Similarity ^@ Belongs to the methylmalonyl-CoA mutase family.|||Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. http://togogenome.org/gene/28377:ppp2r3c ^@ http://purl.uniprot.org/uniprot/G1KA76 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:LOC100551599 ^@ http://purl.uniprot.org/uniprot/G1KWI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm http://togogenome.org/gene/28377:cdc42ep1 ^@ http://purl.uniprot.org/uniprot/G1KRM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/28377:slc6a15 ^@ http://purl.uniprot.org/uniprot/G1KKT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.|||Membrane http://togogenome.org/gene/28377:hsd17b6 ^@ http://purl.uniprot.org/uniprot/A0A803TSY7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:c2 ^@ http://purl.uniprot.org/uniprot/A0A803TNT5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family. Snake venom subfamily.|||Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:kcnj11 ^@ http://purl.uniprot.org/uniprot/G1K877 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.|||Membrane http://togogenome.org/gene/28377:ppp1r9b ^@ http://purl.uniprot.org/uniprot/R4G978 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/28377:spib ^@ http://purl.uniprot.org/uniprot/R4G9Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/28377:gphb5 ^@ http://purl.uniprot.org/uniprot/A0A803T788 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/28377:hyal3 ^@ http://purl.uniprot.org/uniprot/G1KI40 ^@ Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 56 family.|||Monomer. http://togogenome.org/gene/28377:syn2 ^@ http://purl.uniprot.org/uniprot/G1KNS8 ^@ Similarity ^@ Belongs to the synapsin family. http://togogenome.org/gene/28377:cdk20 ^@ http://purl.uniprot.org/uniprot/G1KH48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||cilium http://togogenome.org/gene/28377:plch1 ^@ http://purl.uniprot.org/uniprot/A0A803SZW4|||http://purl.uniprot.org/uniprot/G1KCL6 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/28377:per2 ^@ http://purl.uniprot.org/uniprot/G1KB77 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/28377:tmem59 ^@ http://purl.uniprot.org/uniprot/G1KPI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM59 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:ccne2 ^@ http://purl.uniprot.org/uniprot/G1KCG6 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/28377:fam212b ^@ http://purl.uniprot.org/uniprot/A0A803TR73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INKA family.|||Nucleus http://togogenome.org/gene/28377:kcnn4 ^@ http://purl.uniprot.org/uniprot/H9G9A0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:LOC100560843 ^@ http://purl.uniprot.org/uniprot/R4GBD7 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/28377:ggh ^@ http://purl.uniprot.org/uniprot/G1KT97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C26 family.|||extracellular space http://togogenome.org/gene/28377:pgm5 ^@ http://purl.uniprot.org/uniprot/G1K9N7 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/28377:galnt15 ^@ http://purl.uniprot.org/uniprot/G1KGZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:cacnb1 ^@ http://purl.uniprot.org/uniprot/A0A803SM98|||http://purl.uniprot.org/uniprot/A0A803TH12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||Membrane|||sarcolemma http://togogenome.org/gene/28377:gabra1 ^@ http://purl.uniprot.org/uniprot/G1KQK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/28377:parp4 ^@ http://purl.uniprot.org/uniprot/A0A803TIW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARTD/PARP family.|||Nucleus http://togogenome.org/gene/28377:sod3 ^@ http://purl.uniprot.org/uniprot/G1K8G8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/28377:LOC100567846 ^@ http://purl.uniprot.org/uniprot/G1KGG3 ^@ Function|||Similarity ^@ Belongs to the ohanin/vespryn family.|||Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal. http://togogenome.org/gene/28377:skil ^@ http://purl.uniprot.org/uniprot/G1KRY8 ^@ Similarity ^@ Belongs to the SKI family. http://togogenome.org/gene/28377:isca1 ^@ http://purl.uniprot.org/uniprot/A0A803TJK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/28377:tmem183a ^@ http://purl.uniprot.org/uniprot/G1KDD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM183 family.|||Membrane http://togogenome.org/gene/28377:ppp1r16b ^@ http://purl.uniprot.org/uniprot/A0A803TNZ5|||http://purl.uniprot.org/uniprot/G1KPN6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/28377:prr15l ^@ http://purl.uniprot.org/uniprot/G1KFP4 ^@ Similarity ^@ Belongs to the PRR15 family. http://togogenome.org/gene/28377:glrb ^@ http://purl.uniprot.org/uniprot/G1KT50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/28377:tmem98 ^@ http://purl.uniprot.org/uniprot/A0A803T427 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM98 family.|||Endoplasmic reticulum membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/28377:ythdf3 ^@ http://purl.uniprot.org/uniprot/A0A803TV84|||http://purl.uniprot.org/uniprot/G1KT68 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/28377:tac1 ^@ http://purl.uniprot.org/uniprot/A0A803TFL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted|||Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. http://togogenome.org/gene/28377:alas2 ^@ http://purl.uniprot.org/uniprot/A0A803T105 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/28377:cep70 ^@ http://purl.uniprot.org/uniprot/G1KJ57 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.|||Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.|||centrosome http://togogenome.org/gene/28377:spi1 ^@ http://purl.uniprot.org/uniprot/A0A803SVU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/28377:pik3c3 ^@ http://purl.uniprot.org/uniprot/A0A803TMD1|||http://purl.uniprot.org/uniprot/G1KPF8 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/28377:LOC100566872 ^@ http://purl.uniprot.org/uniprot/G1KRA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase CarF family.|||Membrane http://togogenome.org/gene/28377:vgll4 ^@ http://purl.uniprot.org/uniprot/G1KJY4 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/28377:cfap206 ^@ http://purl.uniprot.org/uniprot/G1KQR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP206 family.|||cilium axoneme http://togogenome.org/gene/28377:LOC100566498 ^@ http://purl.uniprot.org/uniprot/G1KBT9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:snx4 ^@ http://purl.uniprot.org/uniprot/R4GB33 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/28377:LOC100555183 ^@ http://purl.uniprot.org/uniprot/A0A803T7Z6 ^@ Similarity ^@ Belongs to the TMEM178 family. http://togogenome.org/gene/28377:ntf3 ^@ http://purl.uniprot.org/uniprot/A0A803TRM2|||http://purl.uniprot.org/uniprot/G1KIN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted|||Seems to promote the survival of visceral and proprioceptive sensory neurons. http://togogenome.org/gene/28377:tsen2 ^@ http://purl.uniprot.org/uniprot/G1KNL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.|||Nucleus http://togogenome.org/gene/28377:taldo1 ^@ http://purl.uniprot.org/uniprot/G1KQV8 ^@ Function|||Similarity ^@ Belongs to the transaldolase family. Type 1 subfamily.|||Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate. http://togogenome.org/gene/28377:fam49b ^@ http://purl.uniprot.org/uniprot/G1KK20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYRI family.|||Membrane http://togogenome.org/gene/28377:mtx3 ^@ http://purl.uniprot.org/uniprot/G1KSV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/28377:arf3 ^@ http://purl.uniprot.org/uniprot/G1KHJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/28377:LOC100562478 ^@ http://purl.uniprot.org/uniprot/R4GBZ0 ^@ Similarity ^@ Belongs to the tigger transposable element derived protein family. http://togogenome.org/gene/28377:usp14 ^@ http://purl.uniprot.org/uniprot/A0A803TII2|||http://purl.uniprot.org/uniprot/G1KHK9 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C19 family. USP14/UBP6 subfamily.|||Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS. http://togogenome.org/gene/28377:tdo2 ^@ http://purl.uniprot.org/uniprot/G1KT95 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer. Dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:arl6ip5 ^@ http://purl.uniprot.org/uniprot/A0A803TEF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/28377:gab1 ^@ http://purl.uniprot.org/uniprot/A0A803SWY0|||http://purl.uniprot.org/uniprot/A0A803T7T6|||http://purl.uniprot.org/uniprot/G1KBE7 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/28377:phc1 ^@ http://purl.uniprot.org/uniprot/G1KTY4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:kdm4c ^@ http://purl.uniprot.org/uniprot/G1KCZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM3 histone demethylase family.|||Nucleus http://togogenome.org/gene/28377:cpb2 ^@ http://purl.uniprot.org/uniprot/G1KSK1 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/28377:scube2 ^@ http://purl.uniprot.org/uniprot/A0A803TGY9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:anxa5 ^@ http://purl.uniprot.org/uniprot/G1KMZ9 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/28377:LOC100558083 ^@ http://purl.uniprot.org/uniprot/G1KMX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/28377:LOC100564770 ^@ http://purl.uniprot.org/uniprot/A0A803T626|||http://purl.uniprot.org/uniprot/R4G946 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:ehd3 ^@ http://purl.uniprot.org/uniprot/A0A803U1W6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/28377:tmed9 ^@ http://purl.uniprot.org/uniprot/G1KFI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:mterf4 ^@ http://purl.uniprot.org/uniprot/G1KA49 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/28377:fam135b ^@ http://purl.uniprot.org/uniprot/G1KLX4 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/28377:suclg2 ^@ http://purl.uniprot.org/uniprot/A0A803T2D4|||http://purl.uniprot.org/uniprot/G1KQT2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.|||Binds 1 Mg(2+) ion per subunit.|||GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.|||Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.|||Mitochondrion http://togogenome.org/gene/28377:kitlg ^@ http://purl.uniprot.org/uniprot/R4GD07 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCF family.|||Cytoplasm|||Homodimer, non-covalently linked.|||Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.|||Secreted|||filopodium|||lamellipodium http://togogenome.org/gene/28377:sox4 ^@ http://purl.uniprot.org/uniprot/G1KZB1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:tmem2 ^@ http://purl.uniprot.org/uniprot/G1KN10 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/28377:nkain3 ^@ http://purl.uniprot.org/uniprot/A0A803SZ44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100553961 ^@ http://purl.uniprot.org/uniprot/R4G9W3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/28377:stag1 ^@ http://purl.uniprot.org/uniprot/G1KGT0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/28377:me3 ^@ http://purl.uniprot.org/uniprot/G1KB19 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/28377:tgfb3 ^@ http://purl.uniprot.org/uniprot/G1KTG2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.|||extracellular matrix http://togogenome.org/gene/28377:rab9a ^@ http://purl.uniprot.org/uniprot/G1K9R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||phagosome membrane http://togogenome.org/gene/28377:gss ^@ http://purl.uniprot.org/uniprot/G1KGM7 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic GSH synthase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/28377:ihh ^@ http://purl.uniprot.org/uniprot/A0A803TAA8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hedgehog family.|||Cell membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Multimer.|||The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.|||The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. http://togogenome.org/gene/28377:rbfox2 ^@ http://purl.uniprot.org/uniprot/A0A803T119|||http://purl.uniprot.org/uniprot/A0A803TEN8|||http://purl.uniprot.org/uniprot/G1KSS4 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||RNA-binding protein that regulates alternative splicing events. http://togogenome.org/gene/28377:senp7 ^@ http://purl.uniprot.org/uniprot/G1KLK5 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/28377:ccng2 ^@ http://purl.uniprot.org/uniprot/G1KLY4 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/28377:hao1 ^@ http://purl.uniprot.org/uniprot/G1KBH8 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/28377:rpl23 ^@ http://purl.uniprot.org/uniprot/A0A803SPV1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/28377:msl3 ^@ http://purl.uniprot.org/uniprot/G1K9H5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:LOC107982237 ^@ http://purl.uniprot.org/uniprot/G1KPX4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 17 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/28377:sgpl1 ^@ http://purl.uniprot.org/uniprot/G1KI73 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/28377:chst14 ^@ http://purl.uniprot.org/uniprot/G1KVL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:st6galnac1 ^@ http://purl.uniprot.org/uniprot/G1KHU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/28377:dnaja2 ^@ http://purl.uniprot.org/uniprot/H9GK58 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:ptgr2 ^@ http://purl.uniprot.org/uniprot/G1KRZ0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/28377:lsm12 ^@ http://purl.uniprot.org/uniprot/A0A803TRN5 ^@ Similarity ^@ Belongs to the LSM12 family. http://togogenome.org/gene/28377:chd1l ^@ http://purl.uniprot.org/uniprot/G1KUC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/28377:LOC100552242 ^@ http://purl.uniprot.org/uniprot/G1KB61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/28377:pde4d ^@ http://purl.uniprot.org/uniprot/A0A803TEX6|||http://purl.uniprot.org/uniprot/A0A803TQC2|||http://purl.uniprot.org/uniprot/G1KIP2 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/28377:rad50 ^@ http://purl.uniprot.org/uniprot/G1KMS1 ^@ Similarity ^@ Belongs to the SMC family. RAD50 subfamily. http://togogenome.org/gene/28377:slc16a14 ^@ http://purl.uniprot.org/uniprot/G1KE06 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:tspan2 ^@ http://purl.uniprot.org/uniprot/G1KBW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/28377:med8 ^@ http://purl.uniprot.org/uniprot/G1KNT1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 8 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/28377:syk ^@ http://purl.uniprot.org/uniprot/A0A803TC51|||http://purl.uniprot.org/uniprot/G1K8U5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. http://togogenome.org/gene/28377:slc35a5 ^@ http://purl.uniprot.org/uniprot/A0A803TYY4|||http://purl.uniprot.org/uniprot/G1KJW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:myc ^@ http://purl.uniprot.org/uniprot/G1KK08 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus|||Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. http://togogenome.org/gene/28377:tusc3 ^@ http://purl.uniprot.org/uniprot/A0A803TTU8|||http://purl.uniprot.org/uniprot/A0A803U186 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:c1h18orf25 ^@ http://purl.uniprot.org/uniprot/A0A803SPS5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:kcnk1 ^@ http://purl.uniprot.org/uniprot/G1K923 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Cell membrane|||Cytoplasmic vesicle|||Endosome|||Membrane|||Perikaryon|||Recycling endosome|||Synaptic cell membrane|||Vesicle|||dendrite http://togogenome.org/gene/28377:tagln3 ^@ http://purl.uniprot.org/uniprot/G1KQR0 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/28377:cnrip1 ^@ http://purl.uniprot.org/uniprot/G1K8Z6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. http://togogenome.org/gene/28377:pdcd11 ^@ http://purl.uniprot.org/uniprot/G1KDA1 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/28377:mysm1 ^@ http://purl.uniprot.org/uniprot/G1KE68 ^@ Similarity ^@ Belongs to the peptidase M67A family. MYSM1 subfamily. http://togogenome.org/gene/28377:psat1 ^@ http://purl.uniprot.org/uniprot/G1KF15 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.|||Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. http://togogenome.org/gene/28377:orc6 ^@ http://purl.uniprot.org/uniprot/H9GJX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC6 family.|||Nucleus http://togogenome.org/gene/28377:grk7 ^@ http://purl.uniprot.org/uniprot/G1KDL7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/28377:snx18 ^@ http://purl.uniprot.org/uniprot/G1KR67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/28377:LOC100559320 ^@ http://purl.uniprot.org/uniprot/G1KK66 ^@ Function|||Similarity ^@ Belongs to the ohanin/vespryn family.|||Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal. http://togogenome.org/gene/28377:cdh2 ^@ http://purl.uniprot.org/uniprot/G1KKW9 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/28377:rhbdf2 ^@ http://purl.uniprot.org/uniprot/G1KHP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Endoplasmic reticulum membrane|||Membrane|||Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. http://togogenome.org/gene/28377:ghsr ^@ http://purl.uniprot.org/uniprot/G1KSJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:capn7 ^@ http://purl.uniprot.org/uniprot/G1KB21 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/28377:LOC100557674 ^@ http://purl.uniprot.org/uniprot/G1KQY2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:slc1a2 ^@ http://purl.uniprot.org/uniprot/A0A803T2F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/28377:LOC103277689 ^@ http://purl.uniprot.org/uniprot/G1KWE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/28377:LOC103278845 ^@ http://purl.uniprot.org/uniprot/A0A803U182 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/28377:kcne1 ^@ http://purl.uniprot.org/uniprot/G1KDJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the potassium channel KCNE family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100562953 ^@ http://purl.uniprot.org/uniprot/L7MZN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/28377:LOC103279059 ^@ http://purl.uniprot.org/uniprot/A0A803TBM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/28377:pde6g ^@ http://purl.uniprot.org/uniprot/G1KQM6 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/28377:LOC103278483 ^@ http://purl.uniprot.org/uniprot/G1KUR9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:LOC100563155 ^@ http://purl.uniprot.org/uniprot/G1KNS4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:fgf19 ^@ http://purl.uniprot.org/uniprot/G1KS16 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/28377:chl1 ^@ http://purl.uniprot.org/uniprot/A0A803TET0|||http://purl.uniprot.org/uniprot/G1K9T3|||http://purl.uniprot.org/uniprot/R4GA37 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. http://togogenome.org/gene/28377:LOC100557218 ^@ http://purl.uniprot.org/uniprot/G1KTX2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCO1/2 family.|||Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.|||Homodimer.|||Mitochondrion inner membrane http://togogenome.org/gene/28377:tmem70 ^@ http://purl.uniprot.org/uniprot/G1KN55 ^@ Similarity ^@ Belongs to the TMEM70 family. http://togogenome.org/gene/28377:inpp4a ^@ http://purl.uniprot.org/uniprot/G1KML1|||http://purl.uniprot.org/uniprot/R4GBP4 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/28377:LOC100553624 ^@ http://purl.uniprot.org/uniprot/G1K9T2 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/28377:mef2c ^@ http://purl.uniprot.org/uniprot/A0A803T3R7|||http://purl.uniprot.org/uniprot/A0A803T4E6|||http://purl.uniprot.org/uniprot/A0A803THX0|||http://purl.uniprot.org/uniprot/G1K8K0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:kansl2 ^@ http://purl.uniprot.org/uniprot/G1KI58 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.|||Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.|||Nucleus http://togogenome.org/gene/28377:rnf182 ^@ http://purl.uniprot.org/uniprot/G1KC39 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with ATP6V0C.|||Membrane http://togogenome.org/gene/28377:pdhb ^@ http://purl.uniprot.org/uniprot/A0A803TCJ3 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/28377:kcnk10 ^@ http://purl.uniprot.org/uniprot/G1KNM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/28377:gfm2 ^@ http://purl.uniprot.org/uniprot/G1KIH6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.|||Mitochondrion http://togogenome.org/gene/28377:agtpbp1 ^@ http://purl.uniprot.org/uniprot/A0A803TX86|||http://purl.uniprot.org/uniprot/G1K8V2|||http://purl.uniprot.org/uniprot/G1KW25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||cytosol http://togogenome.org/gene/28377:rcl1 ^@ http://purl.uniprot.org/uniprot/G1KC43 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.|||Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.|||nucleolus http://togogenome.org/gene/28377:LOC100566235 ^@ http://purl.uniprot.org/uniprot/A0A803STI1|||http://purl.uniprot.org/uniprot/A0A803T5T5|||http://purl.uniprot.org/uniprot/A0A803TI18|||http://purl.uniprot.org/uniprot/G1KIQ1 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/28377:LOC100567830 ^@ http://purl.uniprot.org/uniprot/G1KN48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urea transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:rap2a ^@ http://purl.uniprot.org/uniprot/A0A803TZK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/28377:wdr82 ^@ http://purl.uniprot.org/uniprot/G1KFK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SWD2 family.|||Nucleus http://togogenome.org/gene/28377:LOC100553449 ^@ http://purl.uniprot.org/uniprot/A0A803T9I6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Homodimer.|||Secreted http://togogenome.org/gene/28377:fam19a2 ^@ http://purl.uniprot.org/uniprot/R4GBI7 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/28377:cfl2 ^@ http://purl.uniprot.org/uniprot/G1KAM4 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/28377:mief1 ^@ http://purl.uniprot.org/uniprot/A0A803TFR7 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/28377:fbxo9 ^@ http://purl.uniprot.org/uniprot/G1KI02 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9).|||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and acts as a regulator of mTOR signaling. http://togogenome.org/gene/28377:LOC100566148 ^@ http://purl.uniprot.org/uniprot/G1KLZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/28377:LOC100566534 ^@ http://purl.uniprot.org/uniprot/G1KBP0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:usmg5 ^@ http://purl.uniprot.org/uniprot/A0A803T945 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion membrane http://togogenome.org/gene/28377:man1a1 ^@ http://purl.uniprot.org/uniprot/G1KUB9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/28377:ddias ^@ http://purl.uniprot.org/uniprot/A0A803SPN2 ^@ Similarity ^@ Belongs to the replication factor A protein 1 family. http://togogenome.org/gene/28377:rbx1 ^@ http://purl.uniprot.org/uniprot/G1KDQ9 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/28377:sv2c ^@ http://purl.uniprot.org/uniprot/G1KHP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/28377:mrpl10 ^@ http://purl.uniprot.org/uniprot/G1KFV8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/28377:rmi1 ^@ http://purl.uniprot.org/uniprot/G1K9F9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RMI1 family.|||Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.|||Nucleus http://togogenome.org/gene/28377:clrn2 ^@ http://purl.uniprot.org/uniprot/G1KKZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/28377:nat9 ^@ http://purl.uniprot.org/uniprot/G1KE42 ^@ Similarity ^@ Belongs to the acetyltransferase family. GNAT subfamily. http://togogenome.org/gene/28377:rpl30 ^@ http://purl.uniprot.org/uniprot/G1KS11 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/28377:tmem80 ^@ http://purl.uniprot.org/uniprot/G1KQQ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:kif26a ^@ http://purl.uniprot.org/uniprot/G1KKU6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/28377:stac2 ^@ http://purl.uniprot.org/uniprot/G1KTZ5 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/28377:LOC103277700 ^@ http://purl.uniprot.org/uniprot/R4G941 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/28377:kdm3b ^@ http://purl.uniprot.org/uniprot/G1KG85 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM2 histone demethylase family.|||Binds 1 Fe(2+) ion per subunit.|||Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.|||Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.|||Nucleus|||The JmjC domain and the C6-type zinc-finger are required for the demethylation activity. http://togogenome.org/gene/28377:yaf2 ^@ http://purl.uniprot.org/uniprot/A0A803TR09|||http://purl.uniprot.org/uniprot/G1KBM8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:unk ^@ http://purl.uniprot.org/uniprot/G1KGG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unkempt family.|||Cytoplasm http://togogenome.org/gene/28377:LOC100560423 ^@ http://purl.uniprot.org/uniprot/G1KC35 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/28377:mapk9 ^@ http://purl.uniprot.org/uniprot/A0A803TPY9|||http://purl.uniprot.org/uniprot/A0A803U046|||http://purl.uniprot.org/uniprot/G1KSZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/28377:tmem184c ^@ http://purl.uniprot.org/uniprot/G1KCB4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:LOC100558542 ^@ http://purl.uniprot.org/uniprot/G1KU16 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:LOC100552698 ^@ http://purl.uniprot.org/uniprot/A0A803TFW8 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/28377:c4h1orf123 ^@ http://purl.uniprot.org/uniprot/G1KI50 ^@ Similarity ^@ Belongs to the UPF0587 family. http://togogenome.org/gene/28377:b3galt1 ^@ http://purl.uniprot.org/uniprot/G1K9L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:gtf2b ^@ http://purl.uniprot.org/uniprot/G1K9D7 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/28377:lamb1 ^@ http://purl.uniprot.org/uniprot/G1KCX1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/28377:fam19a5 ^@ http://purl.uniprot.org/uniprot/A0A803T4Z1|||http://purl.uniprot.org/uniprot/A0A803T529 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/28377:tfb1m ^@ http://purl.uniprot.org/uniprot/A0A803SRT3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/28377:lta4h ^@ http://purl.uniprot.org/uniprot/G1KP96 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/28377:psmc5 ^@ http://purl.uniprot.org/uniprot/G1KUJ0 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/28377:mrpl12 ^@ http://purl.uniprot.org/uniprot/G1KKH4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL12 family. http://togogenome.org/gene/28377:nbn ^@ http://purl.uniprot.org/uniprot/G1KK41 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.|||Component of the MRN complex.|||Nucleus|||telomere http://togogenome.org/gene/28377:foxo1 ^@ http://purl.uniprot.org/uniprot/G1KSU9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:ndc80 ^@ http://purl.uniprot.org/uniprot/G1KI76 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/28377:trpc4 ^@ http://purl.uniprot.org/uniprot/G1KU62 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:rplp2 ^@ http://purl.uniprot.org/uniprot/A0A803TD03 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/28377:ramp2 ^@ http://purl.uniprot.org/uniprot/G1KPU5 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/28377:LOC100558643 ^@ http://purl.uniprot.org/uniprot/G1KRP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/28377:gabra5 ^@ http://purl.uniprot.org/uniprot/G1KL95 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/28377:mlh1 ^@ http://purl.uniprot.org/uniprot/G1KJR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||Nucleus http://togogenome.org/gene/28377:mbtps2 ^@ http://purl.uniprot.org/uniprot/G1KT01 ^@ Similarity ^@ Belongs to the peptidase M50A family. http://togogenome.org/gene/28377:nipa1 ^@ http://purl.uniprot.org/uniprot/G1KMN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/28377:ddx47 ^@ http://purl.uniprot.org/uniprot/G1KKF6 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily. http://togogenome.org/gene/28377:aasdh ^@ http://purl.uniprot.org/uniprot/G1KIG6 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/28377:prrt1 ^@ http://purl.uniprot.org/uniprot/G1KK97 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/28377:LOC100565746 ^@ http://purl.uniprot.org/uniprot/G1KD81 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:ppp2r5a ^@ http://purl.uniprot.org/uniprot/R4GAU5 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family. http://togogenome.org/gene/28377:arl5b ^@ http://purl.uniprot.org/uniprot/A0A803TYC3 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/28377:isl1 ^@ http://purl.uniprot.org/uniprot/G1KCT9|||http://purl.uniprot.org/uniprot/R4GCB0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:wnt2b ^@ http://purl.uniprot.org/uniprot/G1KUI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/28377:fam69c ^@ http://purl.uniprot.org/uniprot/G1KC64 ^@ Similarity ^@ Belongs to the DIPK family. http://togogenome.org/gene/28377:clpp ^@ http://purl.uniprot.org/uniprot/G1KRA1 ^@ Similarity ^@ Belongs to the peptidase S14 family. http://togogenome.org/gene/28377:chst15 ^@ http://purl.uniprot.org/uniprot/G1KU30 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/28377:p2rx7 ^@ http://purl.uniprot.org/uniprot/H9GQC6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P2X receptor family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/28377:aqp1 ^@ http://purl.uniprot.org/uniprot/G1KEQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/28377:LOC100557882 ^@ http://purl.uniprot.org/uniprot/A0A803T8P3|||http://purl.uniprot.org/uniprot/G1KEM0 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/28377:LOC100562752 ^@ http://purl.uniprot.org/uniprot/G1KSL1 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/28377:tdrd3 ^@ http://purl.uniprot.org/uniprot/A0A803T506|||http://purl.uniprot.org/uniprot/G1KDC8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1. http://togogenome.org/gene/28377:pdha1 ^@ http://purl.uniprot.org/uniprot/A0A803TCP6|||http://purl.uniprot.org/uniprot/G1KM26 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. http://togogenome.org/gene/28377:atg13 ^@ http://purl.uniprot.org/uniprot/G1KCG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG13 family. Metazoan subfamily.|||Preautophagosomal structure http://togogenome.org/gene/28377:ncapg ^@ http://purl.uniprot.org/uniprot/G1KAA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND3 (condensin subunit 3) family.|||Chromosome http://togogenome.org/gene/28377:psma6 ^@ http://purl.uniprot.org/uniprot/G1K9Z4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:palmd ^@ http://purl.uniprot.org/uniprot/G1KCD7 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/28377:dnpep ^@ http://purl.uniprot.org/uniprot/G1KP81 ^@ Similarity|||Subunit ^@ Belongs to the peptidase M18 family.|||Tetrahedron-shaped homododecamer built from six homodimers. http://togogenome.org/gene/28377:alox5 ^@ http://purl.uniprot.org/uniprot/G1KP84 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the lipoxygenase family.|||Binds 1 Fe cation per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:pan3 ^@ http://purl.uniprot.org/uniprot/G1KIR2 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. PAN3 family.|||Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.|||Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||P-body|||Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.|||The N-terminal zinc finger binds to poly(A) RNA.|||The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2. http://togogenome.org/gene/28377:tspan13 ^@ http://purl.uniprot.org/uniprot/G1KMK1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:e2f8 ^@ http://purl.uniprot.org/uniprot/G1KRJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/28377:arl6 ^@ http://purl.uniprot.org/uniprot/A0A803SR74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||cilium membrane http://togogenome.org/gene/28377:ntng1 ^@ http://purl.uniprot.org/uniprot/A0A803STG9|||http://purl.uniprot.org/uniprot/A0A803SV50|||http://purl.uniprot.org/uniprot/A0A803T435|||http://purl.uniprot.org/uniprot/A0A803T5D7|||http://purl.uniprot.org/uniprot/A0A803TCD7|||http://purl.uniprot.org/uniprot/G1K9F5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:ntf4 ^@ http://purl.uniprot.org/uniprot/G1KNJ6 ^@ Similarity ^@ Belongs to the NGF-beta family. http://togogenome.org/gene/28377:slc1a1 ^@ http://purl.uniprot.org/uniprot/A0A803TH92|||http://purl.uniprot.org/uniprot/G1KC01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/28377:pik3cg ^@ http://purl.uniprot.org/uniprot/G1KQF3 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/28377:coq3 ^@ http://purl.uniprot.org/uniprot/G1KK62 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Mitochondrion inner membrane|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/28377:adamts1 ^@ http://purl.uniprot.org/uniprot/G1KQ54 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/28377:mpp6 ^@ http://purl.uniprot.org/uniprot/A0A803TEN1|||http://purl.uniprot.org/uniprot/G1KNN4 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/28377:bcl2l13 ^@ http://purl.uniprot.org/uniprot/G1KME5 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/28377:serpinc1 ^@ http://purl.uniprot.org/uniprot/G1KR22 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/28377:opn5 ^@ http://purl.uniprot.org/uniprot/G1KNV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/28377:s100z ^@ http://purl.uniprot.org/uniprot/A0A803TXS3 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/28377:sh3bp5l ^@ http://purl.uniprot.org/uniprot/G1KXP0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SH3BP5 family.|||Cytoplasm|||Functions as guanine nucleotide exchange factor (GEF) for RAB11A.|||Interacts with GDP-bound and nucleotide-free forms of RAB11A.|||The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. http://togogenome.org/gene/28377:iapp ^@ http://purl.uniprot.org/uniprot/G1KTW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcitonin family.|||Secreted http://togogenome.org/gene/28377:nt5dc3 ^@ http://purl.uniprot.org/uniprot/A0A803SPE1|||http://purl.uniprot.org/uniprot/G1KSF7 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/28377:pld4 ^@ http://purl.uniprot.org/uniprot/G1KL33 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/28377:vim ^@ http://purl.uniprot.org/uniprot/G1KDR6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:vipr2 ^@ http://purl.uniprot.org/uniprot/G1KAG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:vdr ^@ http://purl.uniprot.org/uniprot/G1KNX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:cmtr1 ^@ http://purl.uniprot.org/uniprot/G1KQ10 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).|||S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. http://togogenome.org/gene/28377:stk32a ^@ http://purl.uniprot.org/uniprot/G1KPZ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/28377:ccdc85a ^@ http://purl.uniprot.org/uniprot/G1KCF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC85 family.|||adherens junction http://togogenome.org/gene/28377:znf706 ^@ http://purl.uniprot.org/uniprot/G1KI42 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/28377:LOC100564200 ^@ http://purl.uniprot.org/uniprot/A0A803SR03 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:nxph3 ^@ http://purl.uniprot.org/uniprot/A0A803TKQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/28377:psmc2 ^@ http://purl.uniprot.org/uniprot/G1KFN2 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/28377:gabbr2 ^@ http://purl.uniprot.org/uniprot/G1KAG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:mbp ^@ http://purl.uniprot.org/uniprot/A0A803SS85|||http://purl.uniprot.org/uniprot/A0A803TKL9|||http://purl.uniprot.org/uniprot/A0A803TPR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin basic protein family.|||Myelin membrane http://togogenome.org/gene/28377:smim15 ^@ http://purl.uniprot.org/uniprot/G1KI83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM15 family.|||Membrane http://togogenome.org/gene/28377:rrp15 ^@ http://purl.uniprot.org/uniprot/G1KQF4 ^@ Similarity ^@ Belongs to the RRP15 family. http://togogenome.org/gene/28377:orc3 ^@ http://purl.uniprot.org/uniprot/G1KQH7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC3 family.|||Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.|||Nucleus http://togogenome.org/gene/28377:atp5b ^@ http://purl.uniprot.org/uniprot/G1KT22 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/28377:znf330 ^@ http://purl.uniprot.org/uniprot/G1KB20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOA36 family.|||nucleolus http://togogenome.org/gene/28377:plxnb3 ^@ http://purl.uniprot.org/uniprot/G1KHW4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:acvr1b ^@ http://purl.uniprot.org/uniprot/A0A803SW16|||http://purl.uniprot.org/uniprot/G1KT77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane|||Secreted http://togogenome.org/gene/28377:grpel1 ^@ http://purl.uniprot.org/uniprot/G1KA62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/28377:LOC100565110 ^@ http://purl.uniprot.org/uniprot/G1KRT0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:gucy1b3 ^@ http://purl.uniprot.org/uniprot/G1KTC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/28377:iah1 ^@ http://purl.uniprot.org/uniprot/G1K9P3 ^@ Function|||Similarity ^@ Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.|||Probable lipase. http://togogenome.org/gene/28377:tmem205 ^@ http://purl.uniprot.org/uniprot/A0A803TKP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM205 family.|||Membrane http://togogenome.org/gene/28377:rpl5 ^@ http://purl.uniprot.org/uniprot/A0A803TC78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/28377:cdc37 ^@ http://purl.uniprot.org/uniprot/G1KI32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/28377:ywhaq ^@ http://purl.uniprot.org/uniprot/G1K9B0 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/28377:LOC100564396 ^@ http://purl.uniprot.org/uniprot/G1KYT1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:LOC100556582 ^@ http://purl.uniprot.org/uniprot/G1K9X4 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/28377:LOC100565228 ^@ http://purl.uniprot.org/uniprot/A0A803TEJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/28377:grm5 ^@ http://purl.uniprot.org/uniprot/A0A803TND1|||http://purl.uniprot.org/uniprot/G1KQQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:tmem63b ^@ http://purl.uniprot.org/uniprot/A0A803SL79|||http://purl.uniprot.org/uniprot/G1K9L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/28377:matn4 ^@ http://purl.uniprot.org/uniprot/G1KM62 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:sox21 ^@ http://purl.uniprot.org/uniprot/G1KAS3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:acox1 ^@ http://purl.uniprot.org/uniprot/A0A803TM37|||http://purl.uniprot.org/uniprot/G1KH33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/28377:med23 ^@ http://purl.uniprot.org/uniprot/G1K9V6|||http://purl.uniprot.org/uniprot/R4G9H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 23 family.|||Nucleus http://togogenome.org/gene/28377:cc2d1a ^@ http://purl.uniprot.org/uniprot/G1KRR0 ^@ Similarity ^@ Belongs to the CC2D1 family. http://togogenome.org/gene/28377:LOC100565705 ^@ http://purl.uniprot.org/uniprot/A0A803SX99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/28377:stat2 ^@ http://purl.uniprot.org/uniprot/G1KV19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:tpmt ^@ http://purl.uniprot.org/uniprot/G1KBT7 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. http://togogenome.org/gene/28377:nsun2 ^@ http://purl.uniprot.org/uniprot/G1K8Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||extracellular exosome http://togogenome.org/gene/28377:snx13 ^@ http://purl.uniprot.org/uniprot/G1KM72 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/28377:ssbp1 ^@ http://purl.uniprot.org/uniprot/G1KLA3 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/28377:lhfpl3 ^@ http://purl.uniprot.org/uniprot/A0A803T8S2|||http://purl.uniprot.org/uniprot/G1KK04 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:ets2 ^@ http://purl.uniprot.org/uniprot/G1KIR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus|||Transcription factor. http://togogenome.org/gene/28377:rundc3a ^@ http://purl.uniprot.org/uniprot/A0A803T4S8|||http://purl.uniprot.org/uniprot/G1KTQ3 ^@ Similarity ^@ Belongs to the RUNDC3 family. http://togogenome.org/gene/28377:wnt5a ^@ http://purl.uniprot.org/uniprot/G1KTY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/28377:fip1l1 ^@ http://purl.uniprot.org/uniprot/A0A803T897 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus http://togogenome.org/gene/28377:ap4b1 ^@ http://purl.uniprot.org/uniprot/A0A803T7N3 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/28377:LOC100566102 ^@ http://purl.uniprot.org/uniprot/G1KMI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/28377:zdhhc2 ^@ http://purl.uniprot.org/uniprot/G1KF61 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/28377:btg2 ^@ http://purl.uniprot.org/uniprot/G1KJJ2 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/28377:isca2 ^@ http://purl.uniprot.org/uniprot/A0A803TNP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/28377:ano10 ^@ http://purl.uniprot.org/uniprot/A0A803SMN9|||http://purl.uniprot.org/uniprot/A0A803T8K0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:zfyve9 ^@ http://purl.uniprot.org/uniprot/G1KHG2 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Early endosome membrane http://togogenome.org/gene/28377:gtf2h1 ^@ http://purl.uniprot.org/uniprot/G1K887 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/28377:tmed10 ^@ http://purl.uniprot.org/uniprot/A0A803SS95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:brox ^@ http://purl.uniprot.org/uniprot/A0A803SYM4 ^@ Similarity ^@ Belongs to the BROX family. http://togogenome.org/gene/28377:LOC100566150 ^@ http://purl.uniprot.org/uniprot/A0A803TQY1 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/28377:itih5 ^@ http://purl.uniprot.org/uniprot/G1KDB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/28377:cdc42se2 ^@ http://purl.uniprot.org/uniprot/G1K9D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/28377:egfr ^@ http://purl.uniprot.org/uniprot/G1KTY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/28377:fam206a ^@ http://purl.uniprot.org/uniprot/G1K9Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABITRAM family.|||growth cone|||lamellipodium http://togogenome.org/gene/28377:madd ^@ http://purl.uniprot.org/uniprot/A0A803T6I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MADD family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/28377:rbm48 ^@ http://purl.uniprot.org/uniprot/G1KR14 ^@ Function|||Similarity ^@ As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.|||Belongs to the RBM48 family. http://togogenome.org/gene/28377:LOC103277978 ^@ http://purl.uniprot.org/uniprot/G1K8M7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:hoxc9 ^@ http://purl.uniprot.org/uniprot/G1KKM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/28377:LOC100566861 ^@ http://purl.uniprot.org/uniprot/G1KZA1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/28377:lonp2 ^@ http://purl.uniprot.org/uniprot/H9GL04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.|||Belongs to the peptidase S16 family.|||Peroxisome matrix http://togogenome.org/gene/28377:smpdl3a ^@ http://purl.uniprot.org/uniprot/G1K9M3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) per subunit.|||Secreted http://togogenome.org/gene/28377:LOC100564712 ^@ http://purl.uniprot.org/uniprot/A0A803U018 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/28377:elk3 ^@ http://purl.uniprot.org/uniprot/G1KP19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/28377:LOC100552964 ^@ http://purl.uniprot.org/uniprot/G1KK45 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/28377:aste1 ^@ http://purl.uniprot.org/uniprot/G1K9T1 ^@ Similarity ^@ Belongs to the asteroid family. http://togogenome.org/gene/28377:elac2 ^@ http://purl.uniprot.org/uniprot/G1KTV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase Z family.|||mitochondrion nucleoid http://togogenome.org/gene/28377:gpcpd1 ^@ http://purl.uniprot.org/uniprot/A0A803SZ51|||http://purl.uniprot.org/uniprot/A0A803TWN4 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/28377:LOC100562595 ^@ http://purl.uniprot.org/uniprot/A0A803TUP6 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/28377:cse1l ^@ http://purl.uniprot.org/uniprot/G1KRY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPO2/CSE1 family.|||Cytoplasm http://togogenome.org/gene/28377:tspan18 ^@ http://purl.uniprot.org/uniprot/G1KPX8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:inpp4b ^@ http://purl.uniprot.org/uniprot/A0A803T0L6|||http://purl.uniprot.org/uniprot/G1KB71 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/28377:dct ^@ http://purl.uniprot.org/uniprot/G1KB12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/28377:adcy1 ^@ http://purl.uniprot.org/uniprot/G1KHB4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/28377:aldh6a1 ^@ http://purl.uniprot.org/uniprot/G1KSG4 ^@ Function|||Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. http://togogenome.org/gene/28377:sdhaf4 ^@ http://purl.uniprot.org/uniprot/A0A803TG33 ^@ Similarity ^@ Belongs to the SDHAF4 family. http://togogenome.org/gene/28377:ccdc90b ^@ http://purl.uniprot.org/uniprot/G1K9I2 ^@ Similarity ^@ Belongs to the CCDC90 family. http://togogenome.org/gene/28377:ep300 ^@ http://purl.uniprot.org/uniprot/G1KDQ6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/28377:bcl9 ^@ http://purl.uniprot.org/uniprot/G1KP94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BCL9 family.|||Nucleus http://togogenome.org/gene/28377:tmem33 ^@ http://purl.uniprot.org/uniprot/G1KLT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/28377:slc6a19 ^@ http://purl.uniprot.org/uniprot/G1K9X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/28377:cmpk2 ^@ http://purl.uniprot.org/uniprot/G1KG41 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/28377:polr3b ^@ http://purl.uniprot.org/uniprot/G1KR53 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/28377:ing2 ^@ http://purl.uniprot.org/uniprot/G1KFY5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/28377:rarg ^@ http://purl.uniprot.org/uniprot/A0A803SLV9|||http://purl.uniprot.org/uniprot/A0A803SU22|||http://purl.uniprot.org/uniprot/G1KFW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/28377:gcat ^@ http://purl.uniprot.org/uniprot/G1KR54 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/28377:ca3 ^@ http://purl.uniprot.org/uniprot/G1KY16 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/28377:LOC100553170 ^@ http://purl.uniprot.org/uniprot/A0A803TUI8 ^@ Function|||Similarity ^@ Belongs to the ohanin/vespryn family.|||Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal. http://togogenome.org/gene/28377:slc20a2 ^@ http://purl.uniprot.org/uniprot/A0A803SKW2|||http://purl.uniprot.org/uniprot/G1KIP7|||http://purl.uniprot.org/uniprot/R4G9N4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/28377:adgrg6 ^@ http://purl.uniprot.org/uniprot/A0A803TQD1|||http://purl.uniprot.org/uniprot/G1KHR0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:fgf18 ^@ http://purl.uniprot.org/uniprot/A0A803T3T2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/28377:fyn ^@ http://purl.uniprot.org/uniprot/A0A803T3N6|||http://purl.uniprot.org/uniprot/A0A803TM61|||http://purl.uniprot.org/uniprot/G1KLG4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/28377:numb ^@ http://purl.uniprot.org/uniprot/A0A803SXF5|||http://purl.uniprot.org/uniprot/G1KS68|||http://purl.uniprot.org/uniprot/R4GAY9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Plays a role in the process of neurogenesis. http://togogenome.org/gene/28377:elovl6 ^@ http://purl.uniprot.org/uniprot/A0A803T7R7|||http://purl.uniprot.org/uniprot/A0A803TM80 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Belongs to the ELO family. ELOVL6 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-Glycosylated. http://togogenome.org/gene/28377:best4 ^@ http://purl.uniprot.org/uniprot/G1KRF2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms chloride channels.|||Membrane http://togogenome.org/gene/28377:parvg ^@ http://purl.uniprot.org/uniprot/A0A803STC9 ^@ Similarity ^@ Belongs to the parvin family. http://togogenome.org/gene/28377:epha4 ^@ http://purl.uniprot.org/uniprot/G1KDW5 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome|||Membrane http://togogenome.org/gene/28377:lipg ^@ http://purl.uniprot.org/uniprot/G1KUM0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:cldn11 ^@ http://purl.uniprot.org/uniprot/G1KS09 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/28377:ldlrad1 ^@ http://purl.uniprot.org/uniprot/G1KPG8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:slc7a14 ^@ http://purl.uniprot.org/uniprot/G1KS19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:inpp5a ^@ http://purl.uniprot.org/uniprot/G1KEM1 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family. http://togogenome.org/gene/28377:cpa6 ^@ http://purl.uniprot.org/uniprot/G1KSF0 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/28377:fam19a4 ^@ http://purl.uniprot.org/uniprot/R4G9F8 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/28377:LOC100554740 ^@ http://purl.uniprot.org/uniprot/G1KEP9 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/28377:unc50 ^@ http://purl.uniprot.org/uniprot/G1KMM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-50 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/28377:taz ^@ http://purl.uniprot.org/uniprot/G1KMR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the taffazin family.|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/28377:tssc1 ^@ http://purl.uniprot.org/uniprot/G1KEQ7 ^@ Similarity ^@ Belongs to the WD repeat EIPR1 family. http://togogenome.org/gene/28377:LOC103278024 ^@ http://purl.uniprot.org/uniprot/A0A803T4W6 ^@ Function|||Similarity ^@ Belongs to the ohanin/vespryn family.|||Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal. http://togogenome.org/gene/28377:LOC100562413 ^@ http://purl.uniprot.org/uniprot/G1KAF8 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/28377:plp2 ^@ http://purl.uniprot.org/uniprot/R4GDD4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:c1galt1 ^@ http://purl.uniprot.org/uniprot/G1KN54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.|||Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.|||Membrane http://togogenome.org/gene/28377:gc ^@ http://purl.uniprot.org/uniprot/G1KNL0 ^@ Function|||Subcellular Location Annotation ^@ Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.|||Secreted http://togogenome.org/gene/28377:slc4a1 ^@ http://purl.uniprot.org/uniprot/G1KTP9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:ccnb1 ^@ http://purl.uniprot.org/uniprot/G1KSK4 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/28377:lrrfip2 ^@ http://purl.uniprot.org/uniprot/G1KJL5 ^@ Similarity ^@ Belongs to the LRRFIP family. http://togogenome.org/gene/28377:entpd7 ^@ http://purl.uniprot.org/uniprot/G1KC74 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/28377:appl2 ^@ http://purl.uniprot.org/uniprot/G1KRF1 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Membrane|||Nucleus|||phagosome|||ruffle http://togogenome.org/gene/28377:dmrta1 ^@ http://purl.uniprot.org/uniprot/G1KU29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/28377:zdhhc11 ^@ http://purl.uniprot.org/uniprot/A0A803T4Z4 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/28377:fev ^@ http://purl.uniprot.org/uniprot/A0A803TP37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/28377:phf10 ^@ http://purl.uniprot.org/uniprot/G1KEE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAYP family.|||Nucleus http://togogenome.org/gene/28377:ypel5 ^@ http://purl.uniprot.org/uniprot/A0A803SQ29 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/28377:LOC100560217 ^@ http://purl.uniprot.org/uniprot/G1KWY8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/28377:dnajb12 ^@ http://purl.uniprot.org/uniprot/A0A803TMX9|||http://purl.uniprot.org/uniprot/G1K918 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:gata5 ^@ http://purl.uniprot.org/uniprot/G1KDJ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:LOC100558338 ^@ http://purl.uniprot.org/uniprot/A0A803TH21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/28377:dyrk1a ^@ http://purl.uniprot.org/uniprot/G1KII2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/28377:rps16 ^@ http://purl.uniprot.org/uniprot/G1KPL2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/28377:nrdc ^@ http://purl.uniprot.org/uniprot/G1KHA3 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/28377:LOC100565570 ^@ http://purl.uniprot.org/uniprot/G1KSR7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/28377:gpr141 ^@ http://purl.uniprot.org/uniprot/A0A803SLQ4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100565481 ^@ http://purl.uniprot.org/uniprot/M1ZMM8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/28377:nus1 ^@ http://purl.uniprot.org/uniprot/G1KPR7 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/28377:jagn1 ^@ http://purl.uniprot.org/uniprot/G1KJC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the jagunal family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:gja5 ^@ http://purl.uniprot.org/uniprot/G1KPB5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/28377:LOC100558522 ^@ http://purl.uniprot.org/uniprot/G1KTH4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:cpt1a ^@ http://purl.uniprot.org/uniprot/A0A803SMQ6|||http://purl.uniprot.org/uniprot/G1KPJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/28377:calcb ^@ http://purl.uniprot.org/uniprot/A0A803U0U0|||http://purl.uniprot.org/uniprot/G1KMP3 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/28377:LOC100560662 ^@ http://purl.uniprot.org/uniprot/A0A803T8B7 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. http://togogenome.org/gene/28377:naaladl2 ^@ http://purl.uniprot.org/uniprot/R4GB38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Membrane http://togogenome.org/gene/28377:mtrf1 ^@ http://purl.uniprot.org/uniprot/A0A803SWP5|||http://purl.uniprot.org/uniprot/G1K8Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/28377:pbx2 ^@ http://purl.uniprot.org/uniprot/G1KMK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/28377:en2 ^@ http://purl.uniprot.org/uniprot/G1KKR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Engrailed homeobox family.|||Nucleus http://togogenome.org/gene/28377:myod1 ^@ http://purl.uniprot.org/uniprot/A0A803U034 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/28377:prkab2 ^@ http://purl.uniprot.org/uniprot/G1KNE5 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/28377:LOC100554472 ^@ http://purl.uniprot.org/uniprot/G1KWQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/28377:tmem45a ^@ http://purl.uniprot.org/uniprot/G1KL80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/28377:pax6 ^@ http://purl.uniprot.org/uniprot/A0A803TIT1|||http://purl.uniprot.org/uniprot/G1KAP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/28377:msra ^@ http://purl.uniprot.org/uniprot/G1KJN4 ^@ Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family. http://togogenome.org/gene/28377:bace2 ^@ http://purl.uniprot.org/uniprot/G1KET0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Endosome|||Membrane http://togogenome.org/gene/28377:bet1l ^@ http://purl.uniprot.org/uniprot/A0A803T2V1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:kcnk15 ^@ http://purl.uniprot.org/uniprot/G1KWT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/28377:nkx2-2 ^@ http://purl.uniprot.org/uniprot/G1KEI4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:ada ^@ http://purl.uniprot.org/uniprot/G1KT90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Cell junction|||Cell membrane|||Cytoplasmic vesicle lumen http://togogenome.org/gene/28377:tmem50b ^@ http://purl.uniprot.org/uniprot/G1KCM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/28377:atp2a2 ^@ http://purl.uniprot.org/uniprot/H9GN00 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/28377:ptgis ^@ http://purl.uniprot.org/uniprot/G1KRR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/28377:prpf18 ^@ http://purl.uniprot.org/uniprot/G1K8V0|||http://purl.uniprot.org/uniprot/R4GAS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/28377:gtf2h4 ^@ http://purl.uniprot.org/uniprot/G1KK03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.|||Nucleus http://togogenome.org/gene/28377:rpe ^@ http://purl.uniprot.org/uniprot/G1KKI6 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/28377:ptrf ^@ http://purl.uniprot.org/uniprot/G1KUJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/28377:pwp2 ^@ http://purl.uniprot.org/uniprot/G1KUF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PWP2 family.|||nucleolus http://togogenome.org/gene/28377:LOC100567523 ^@ http://purl.uniprot.org/uniprot/G1KB82 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/28377:rgs7bp ^@ http://purl.uniprot.org/uniprot/G1KRB0 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/28377:postn ^@ http://purl.uniprot.org/uniprot/A0A803SYR2|||http://purl.uniprot.org/uniprot/A0A803TMA7|||http://purl.uniprot.org/uniprot/A0A803TQ92|||http://purl.uniprot.org/uniprot/A0A803TVY1|||http://purl.uniprot.org/uniprot/G1KU83 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/28377:slc25a10 ^@ http://purl.uniprot.org/uniprot/G1KKH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/28377:tv23b ^@ http://purl.uniprot.org/uniprot/G1KU77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/28377:dhx29 ^@ http://purl.uniprot.org/uniprot/G1KR16 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.|||Belongs to the DEAD box helicase family. DEAH subfamily.|||Cytoplasm|||Part of the 43S pre-initiation complex (PIC). http://togogenome.org/gene/28377:tceanc2 ^@ http://purl.uniprot.org/uniprot/A0A803T6D4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:acss2 ^@ http://purl.uniprot.org/uniprot/A0A803T8T3|||http://purl.uniprot.org/uniprot/G1KGH1 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/28377:chsy3 ^@ http://purl.uniprot.org/uniprot/G1K9G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/28377:traf6 ^@ http://purl.uniprot.org/uniprot/A0A803T038 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family. A subfamily.|||Lipid droplet|||Nucleus|||cell cortex http://togogenome.org/gene/28377:gcsh ^@ http://purl.uniprot.org/uniprot/H9GEJ4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/28377:tsr2 ^@ http://purl.uniprot.org/uniprot/A0A803T7C1 ^@ Function|||Similarity ^@ Belongs to the TSR2 family.|||May be involved in 20S pre-rRNA processing. http://togogenome.org/gene/28377:rrp1b ^@ http://purl.uniprot.org/uniprot/G1KUF1 ^@ Similarity ^@ Belongs to the RRP1 family. http://togogenome.org/gene/28377:qki ^@ http://purl.uniprot.org/uniprot/G1KBR3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/28377:fgf1 ^@ http://purl.uniprot.org/uniprot/A0A803SLR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Cytoplasm|||Nucleus|||Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.|||Secreted|||cell cortex|||cytosol http://togogenome.org/gene/28377:mccc2 ^@ http://purl.uniprot.org/uniprot/G1KJJ7 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/28377:kif16b ^@ http://purl.uniprot.org/uniprot/G1K8J9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/28377:mpped2 ^@ http://purl.uniprot.org/uniprot/G1KW46 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/28377:fgg ^@ http://purl.uniprot.org/uniprot/G1KRE0 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/28377:stx6 ^@ http://purl.uniprot.org/uniprot/G1KD93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Golgi apparatus membrane http://togogenome.org/gene/28377:nr4a1 ^@ http://purl.uniprot.org/uniprot/G1KT44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR4 subfamily.|||In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7.|||Nucleus|||cytosol http://togogenome.org/gene/28377:mrpl27 ^@ http://purl.uniprot.org/uniprot/G1KDU3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/28377:tmem132c ^@ http://purl.uniprot.org/uniprot/A0A803TPS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM132 family.|||Membrane http://togogenome.org/gene/28377:kif21a ^@ http://purl.uniprot.org/uniprot/G1KHC9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/28377:zdhhc20 ^@ http://purl.uniprot.org/uniprot/A0A803TNM9|||http://purl.uniprot.org/uniprot/G1KB70 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/28377:ptcd3 ^@ http://purl.uniprot.org/uniprot/G1KLU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS39 family.|||Mitochondrion http://togogenome.org/gene/28377:sft2d3 ^@ http://purl.uniprot.org/uniprot/A0A803SPE9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/28377:ca10 ^@ http://purl.uniprot.org/uniprot/G1KTU6 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Does not have a catalytic activity. http://togogenome.org/gene/28377:ppp4r2 ^@ http://purl.uniprot.org/uniprot/G1KQF0 ^@ Similarity ^@ Belongs to the PPP4R2 family. http://togogenome.org/gene/28377:tcta ^@ http://purl.uniprot.org/uniprot/A0A803U0H8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCTA family.|||Membrane http://togogenome.org/gene/28377:LOC100555783 ^@ http://purl.uniprot.org/uniprot/G1KFM8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/28377:aldob ^@ http://purl.uniprot.org/uniprot/A0A803SNH7|||http://purl.uniprot.org/uniprot/G1KTX7 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/28377:rassf1 ^@ http://purl.uniprot.org/uniprot/A0A803TAD7 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/28377:rapsn ^@ http://purl.uniprot.org/uniprot/G1KAG0 ^@ Similarity ^@ Belongs to the RAPsyn family. http://togogenome.org/gene/28377:ilkap ^@ http://purl.uniprot.org/uniprot/G1KFI7 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/28377:adck1 ^@ http://purl.uniprot.org/uniprot/G1KTR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Secreted http://togogenome.org/gene/28377:nudt4 ^@ http://purl.uniprot.org/uniprot/G1KMG1 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/28377:LOC100557669 ^@ http://purl.uniprot.org/uniprot/G1KR50 ^@ Similarity ^@ Belongs to the peptidase S1 family. Snake venom subfamily. http://togogenome.org/gene/28377:slco1a2 ^@ http://purl.uniprot.org/uniprot/A0A803SKW6|||http://purl.uniprot.org/uniprot/G1KTZ7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:stx19 ^@ http://purl.uniprot.org/uniprot/G1K8L2 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/28377:enah ^@ http://purl.uniprot.org/uniprot/A0A803TNH2|||http://purl.uniprot.org/uniprot/G1KEM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ena/VASP family.|||cytoskeleton http://togogenome.org/gene/28377:chmp5 ^@ http://purl.uniprot.org/uniprot/A0A803SKY8 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/28377:tgif1 ^@ http://purl.uniprot.org/uniprot/A0A803TS58 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:LOC100562555 ^@ http://purl.uniprot.org/uniprot/G1KSP0 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/28377:LOC100567136 ^@ http://purl.uniprot.org/uniprot/G1KMC5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:kcns1 ^@ http://purl.uniprot.org/uniprot/G1KM14 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:flvcr2 ^@ http://purl.uniprot.org/uniprot/A0A803SMW4|||http://purl.uniprot.org/uniprot/G1KTC7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:LOC100566354 ^@ http://purl.uniprot.org/uniprot/R4GCB7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:hnf4g ^@ http://purl.uniprot.org/uniprot/G1KNJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/28377:lhfpl4 ^@ http://purl.uniprot.org/uniprot/A0A803T3I2|||http://purl.uniprot.org/uniprot/A0A803TJI2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:LOC100561092 ^@ http://purl.uniprot.org/uniprot/G1KPR6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/28377:pcnx1 ^@ http://purl.uniprot.org/uniprot/G1KD95 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:LOC100566415 ^@ http://purl.uniprot.org/uniprot/G1KLQ7 ^@ Function|||Similarity ^@ Belongs to the ohanin/vespryn family.|||Neurotoxin that produces dose-dependent hypolocomotion and hyperalgesia in mice. May directly act on the central nervous system, as it is 6500-fold more potent when administered intracerebroventricularly than intraperitoneal. http://togogenome.org/gene/28377:dlx3 ^@ http://purl.uniprot.org/uniprot/A0A803TF43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/28377:edil3 ^@ http://purl.uniprot.org/uniprot/G1KL84 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:sept2 ^@ http://purl.uniprot.org/uniprot/G1K9J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Midbody|||cilium membrane|||spindle http://togogenome.org/gene/28377:psmb1 ^@ http://purl.uniprot.org/uniprot/G1KAZ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:cd164 ^@ http://purl.uniprot.org/uniprot/A0A803TD01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane http://togogenome.org/gene/28377:vps37b ^@ http://purl.uniprot.org/uniprot/H9GMN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/28377:fnip2 ^@ http://purl.uniprot.org/uniprot/A0A803T985|||http://purl.uniprot.org/uniprot/A0A803TU13|||http://purl.uniprot.org/uniprot/G1KSM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNIP family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/28377:etv1 ^@ http://purl.uniprot.org/uniprot/A0A803TE69|||http://purl.uniprot.org/uniprot/A0A803TGZ3|||http://purl.uniprot.org/uniprot/A0A803TL52|||http://purl.uniprot.org/uniprot/G1KNE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/28377:asic1 ^@ http://purl.uniprot.org/uniprot/A0A803TTZ0|||http://purl.uniprot.org/uniprot/G1KTF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:mrps14 ^@ http://purl.uniprot.org/uniprot/A0A803TRZ3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/28377:sprtn ^@ http://purl.uniprot.org/uniprot/G1KB79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Spartan family.|||Chromosome|||Nucleus http://togogenome.org/gene/28377:sec61b ^@ http://purl.uniprot.org/uniprot/G1KIE1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/28377:rab33b ^@ http://purl.uniprot.org/uniprot/G1KAE4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/28377:LOC103278754 ^@ http://purl.uniprot.org/uniprot/R4GC76 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:LOC100565748 ^@ http://purl.uniprot.org/uniprot/G1KK37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/28377:eif2b2 ^@ http://purl.uniprot.org/uniprot/G1KT52 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/28377:cmtm8 ^@ http://purl.uniprot.org/uniprot/R4G9M5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:LOC100551649 ^@ http://purl.uniprot.org/uniprot/A0A803SS02 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/28377:LOC100557286 ^@ http://purl.uniprot.org/uniprot/R4GAB8 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/28377:nelfe ^@ http://purl.uniprot.org/uniprot/G1KLE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM NELF-E family.|||Chromosome|||Nucleus http://togogenome.org/gene/28377:riok2 ^@ http://purl.uniprot.org/uniprot/G1KLM0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/28377:ptpn14 ^@ http://purl.uniprot.org/uniprot/G1KF00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/28377:clk1 ^@ http://purl.uniprot.org/uniprot/G1KTF0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/28377:rara ^@ http://purl.uniprot.org/uniprot/A0A803T1B0|||http://purl.uniprot.org/uniprot/G1KAS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/28377:wdfy1 ^@ http://purl.uniprot.org/uniprot/G1KCW8 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/28377:tigd1 ^@ http://purl.uniprot.org/uniprot/G1KUS1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:arrdc3 ^@ http://purl.uniprot.org/uniprot/G1KNQ9 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/28377:adck2 ^@ http://purl.uniprot.org/uniprot/G1KKX0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/28377:pdgfra ^@ http://purl.uniprot.org/uniprot/G1KK54 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.|||Membrane|||Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.|||Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. http://togogenome.org/gene/28377:immp1l ^@ http://purl.uniprot.org/uniprot/G1KAB0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Mitochondrion inner membrane http://togogenome.org/gene/28377:dpt ^@ http://purl.uniprot.org/uniprot/G1KKE7 ^@ Similarity ^@ Belongs to the dermatopontin family. http://togogenome.org/gene/28377:c2h5orf63 ^@ http://purl.uniprot.org/uniprot/A0A803U1W1 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/28377:atp6v0a2 ^@ http://purl.uniprot.org/uniprot/H9GM07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/28377:crhr1 ^@ http://purl.uniprot.org/uniprot/G1KUI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:ltn1 ^@ http://purl.uniprot.org/uniprot/G1K9J2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LTN1 family.|||Component of the ribosome quality control complex (RQC).|||E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.|||cytosol http://togogenome.org/gene/28377:rimklb ^@ http://purl.uniprot.org/uniprot/G1KTW5 ^@ Similarity ^@ Belongs to the RimK family. http://togogenome.org/gene/28377:LOC100556446 ^@ http://purl.uniprot.org/uniprot/G1KYJ0 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/28377:LOC103278941 ^@ http://purl.uniprot.org/uniprot/G1KYY2 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/28377:pomt2 ^@ http://purl.uniprot.org/uniprot/G1KTL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/28377:asrgl1 ^@ http://purl.uniprot.org/uniprot/G1KHY8 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/28377:manea ^@ http://purl.uniprot.org/uniprot/G1KAJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:mcm5 ^@ http://purl.uniprot.org/uniprot/G1KSW1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/28377:LOC100558396 ^@ http://purl.uniprot.org/uniprot/G1KVB5 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.|||Membrane http://togogenome.org/gene/28377:smarca5 ^@ http://purl.uniprot.org/uniprot/G1KBM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.|||Nucleus http://togogenome.org/gene/28377:vrk1 ^@ http://purl.uniprot.org/uniprot/G1KP35 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/28377:nhp2 ^@ http://purl.uniprot.org/uniprot/G1KFL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/28377:pax3 ^@ http://purl.uniprot.org/uniprot/G1KDH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/28377:lin7a ^@ http://purl.uniprot.org/uniprot/G1KPW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-7 family.|||Cell junction|||Cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. http://togogenome.org/gene/28377:LOC100560231 ^@ http://purl.uniprot.org/uniprot/G1KVG1 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/28377:dync2h1 ^@ http://purl.uniprot.org/uniprot/G1KM78 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/28377:pex3 ^@ http://purl.uniprot.org/uniprot/G1KHF4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with PEX19.|||Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.|||Peroxisome membrane http://togogenome.org/gene/28377:b9d2 ^@ http://purl.uniprot.org/uniprot/H9G827 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/28377:dusp9 ^@ http://purl.uniprot.org/uniprot/G1KIJ6 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/28377:LOC103277827 ^@ http://purl.uniprot.org/uniprot/A0A803T3R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:ap3b1 ^@ http://purl.uniprot.org/uniprot/A0A803SMF1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes large subunit family.|||Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.|||clathrin-coated vesicle membrane http://togogenome.org/gene/28377:slc29a3 ^@ http://purl.uniprot.org/uniprot/G1KRZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/28377:grpr ^@ http://purl.uniprot.org/uniprot/G1KTG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:aplnr ^@ http://purl.uniprot.org/uniprot/L7MZR0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:LOC100566351 ^@ http://purl.uniprot.org/uniprot/G1KRR3 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:LOC103277701 ^@ http://purl.uniprot.org/uniprot/A0A803TLA5 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/28377:LOC100568046 ^@ http://purl.uniprot.org/uniprot/L7MZN3 ^@ Similarity ^@ Belongs to the TCAF family. http://togogenome.org/gene/28377:tgfbr2 ^@ http://purl.uniprot.org/uniprot/G1KPQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane|||Membrane raft|||Secreted http://togogenome.org/gene/28377:pik3ca ^@ http://purl.uniprot.org/uniprot/G1KDE7 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/28377:LOC100560252 ^@ http://purl.uniprot.org/uniprot/G1KRJ2 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/28377:ninj2 ^@ http://purl.uniprot.org/uniprot/A0A803TMA4|||http://purl.uniprot.org/uniprot/G1K861 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ninjurin family.|||Membrane http://togogenome.org/gene/28377:cldn12 ^@ http://purl.uniprot.org/uniprot/G1KRP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Membrane|||tight junction http://togogenome.org/gene/28377:idnk ^@ http://purl.uniprot.org/uniprot/G1KA38 ^@ Similarity ^@ Belongs to the gluconokinase GntK/GntV family. http://togogenome.org/gene/28377:shh ^@ http://purl.uniprot.org/uniprot/A0A803SKN6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hedgehog family.|||Cell membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Multimer.|||The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.|||The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. http://togogenome.org/gene/28377:osgepl1 ^@ http://purl.uniprot.org/uniprot/G1KPS6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Mitochondrion|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. http://togogenome.org/gene/28377:bgn ^@ http://purl.uniprot.org/uniprot/G1KJA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||May be involved in collagen fiber assembly.|||extracellular matrix http://togogenome.org/gene/28377:LOC100560301 ^@ http://purl.uniprot.org/uniprot/G1KJ64 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/28377:LOC100558194 ^@ http://purl.uniprot.org/uniprot/A0A803TN37 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/28377:rfx3 ^@ http://purl.uniprot.org/uniprot/G1KBT1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:LOC103278072 ^@ http://purl.uniprot.org/uniprot/A0A803TBZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Membrane|||Secreted|||The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. http://togogenome.org/gene/28377:kcnj8 ^@ http://purl.uniprot.org/uniprot/G1KTJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/28377:senp6 ^@ http://purl.uniprot.org/uniprot/A0A803T835|||http://purl.uniprot.org/uniprot/A0A803TA42|||http://purl.uniprot.org/uniprot/G1KDF3 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/28377:LOC100552666 ^@ http://purl.uniprot.org/uniprot/H9GLW2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Refilin family.|||Interacts with FLNA and FLNB.|||cytoskeleton http://togogenome.org/gene/28377:jag1 ^@ http://purl.uniprot.org/uniprot/G1K9X7 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/28377:il17rb ^@ http://purl.uniprot.org/uniprot/G1KLE5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/28377:slc16a3 ^@ http://purl.uniprot.org/uniprot/G1KAX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/28377:ano6 ^@ http://purl.uniprot.org/uniprot/A0A803T2F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:cdc20 ^@ http://purl.uniprot.org/uniprot/G1KNN9 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/28377:prkaa1 ^@ http://purl.uniprot.org/uniprot/A0A803T6Q0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/28377:lrrc16a ^@ http://purl.uniprot.org/uniprot/G1K9V1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CARMIL family.|||Cytoplasm http://togogenome.org/gene/28377:pigm ^@ http://purl.uniprot.org/uniprot/G1KBW8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGM family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.|||Membrane http://togogenome.org/gene/28377:hook1 ^@ http://purl.uniprot.org/uniprot/G1KGA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hook family.|||cytoskeleton http://togogenome.org/gene/28377:xpr1 ^@ http://purl.uniprot.org/uniprot/G1KDD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SYG1 (TC 2.A.94) family.|||Membrane http://togogenome.org/gene/28377:cep19 ^@ http://purl.uniprot.org/uniprot/G1KSD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP19 family.|||centriole|||cilium basal body|||spindle pole http://togogenome.org/gene/28377:stxbp2 ^@ http://purl.uniprot.org/uniprot/G1KTL2 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/28377:gfap ^@ http://purl.uniprot.org/uniprot/A0A803TEM3|||http://purl.uniprot.org/uniprot/G1KGU4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:fam188a ^@ http://purl.uniprot.org/uniprot/G1KSW3 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/28377:anapc16 ^@ http://purl.uniprot.org/uniprot/G1K970 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC16 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||Cytoplasm|||Nucleus|||kinetochore http://togogenome.org/gene/28377:jak2 ^@ http://purl.uniprot.org/uniprot/G1KCE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|||Endomembrane system|||Nucleus http://togogenome.org/gene/28377:slc22a18 ^@ http://purl.uniprot.org/uniprot/G1KZB5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:mast4 ^@ http://purl.uniprot.org/uniprot/A0A803TNC4|||http://purl.uniprot.org/uniprot/A0A803TNR3|||http://purl.uniprot.org/uniprot/G1KSD0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/28377:eif1 ^@ http://purl.uniprot.org/uniprot/A0A803T3C4 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/28377:dnm2 ^@ http://purl.uniprot.org/uniprot/A0A803SQT7|||http://purl.uniprot.org/uniprot/A0A803SST4|||http://purl.uniprot.org/uniprot/G1KR95 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/28377:fam188b ^@ http://purl.uniprot.org/uniprot/G1KEN1 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/28377:cblb ^@ http://purl.uniprot.org/uniprot/A0A803T3M5 ^@ Domain|||Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.|||The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. http://togogenome.org/gene/28377:LOC100556505 ^@ http://purl.uniprot.org/uniprot/G1KB86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/28377:LOC107982244 ^@ http://purl.uniprot.org/uniprot/A0A803SYY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.|||Nucleus http://togogenome.org/gene/28377:slc26a5 ^@ http://purl.uniprot.org/uniprot/G1KFT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/28377:scrn2 ^@ http://purl.uniprot.org/uniprot/G1KFU7 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/28377:myo1d ^@ http://purl.uniprot.org/uniprot/A0A803SLZ0|||http://purl.uniprot.org/uniprot/G1KSK0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/28377:sh3pxd2b ^@ http://purl.uniprot.org/uniprot/A0A803SNN9|||http://purl.uniprot.org/uniprot/A0A803SPR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3PXD2 family.|||Cytoplasm http://togogenome.org/gene/28377:psmc3ip ^@ http://purl.uniprot.org/uniprot/G1KP46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HOP2 family.|||Nucleus http://togogenome.org/gene/28377:ostc ^@ http://purl.uniprot.org/uniprot/G1KMF8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OSTC family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/28377:sema3a ^@ http://purl.uniprot.org/uniprot/G1KSF9 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:nav3 ^@ http://purl.uniprot.org/uniprot/G1KQ75 ^@ Similarity ^@ Belongs to the Nav/unc-53 family. http://togogenome.org/gene/28377:scrn1 ^@ http://purl.uniprot.org/uniprot/G1K8W8 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/28377:akap9 ^@ http://purl.uniprot.org/uniprot/A0A803SVH7 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/28377:slc46a3 ^@ http://purl.uniprot.org/uniprot/G1KJ59 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:vcan ^@ http://purl.uniprot.org/uniprot/G1KL45 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/28377:kctd3 ^@ http://purl.uniprot.org/uniprot/G1KU80 ^@ Similarity ^@ Belongs to the KCTD3 family. http://togogenome.org/gene/28377:pitx2 ^@ http://purl.uniprot.org/uniprot/A0A803T1S7|||http://purl.uniprot.org/uniprot/G1KUT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/28377:tlr2 ^@ http://purl.uniprot.org/uniprot/G1KUN2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.|||Membrane http://togogenome.org/gene/28377:LOC100564832 ^@ http://purl.uniprot.org/uniprot/G1KPB0 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/28377:mllt3 ^@ http://purl.uniprot.org/uniprot/G1KU76 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:slc11a2 ^@ http://purl.uniprot.org/uniprot/G1KMM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAMP family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/28377:rps5 ^@ http://purl.uniprot.org/uniprot/A0A803TUU8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/28377:arfgef2 ^@ http://purl.uniprot.org/uniprot/A0A803SLE5|||http://purl.uniprot.org/uniprot/G1KS74 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||perinuclear region http://togogenome.org/gene/28377:naa10 ^@ http://purl.uniprot.org/uniprot/G1KM18 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/28377:xrcc6 ^@ http://purl.uniprot.org/uniprot/G1KCX9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:ube2b ^@ http://purl.uniprot.org/uniprot/G1KAU9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/28377:LOC100565293 ^@ http://purl.uniprot.org/uniprot/R4GDK2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/28377:ccdc93 ^@ http://purl.uniprot.org/uniprot/G1KA46 ^@ Similarity ^@ Belongs to the CCDC93 family. http://togogenome.org/gene/28377:pi15 ^@ http://purl.uniprot.org/uniprot/A0A803TEC4 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/28377:prokr1 ^@ http://purl.uniprot.org/uniprot/G1K8T3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:gpr68 ^@ http://purl.uniprot.org/uniprot/G1KJC5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:skiv2l ^@ http://purl.uniprot.org/uniprot/G1KLS9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/28377:LOC100561568 ^@ http://purl.uniprot.org/uniprot/G1KT60 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/28377:mrps18c ^@ http://purl.uniprot.org/uniprot/G1KKN1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS18 family. http://togogenome.org/gene/28377:nfyb ^@ http://purl.uniprot.org/uniprot/G1KS07 ^@ Function|||Similarity ^@ Belongs to the NFYB/HAP3 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. http://togogenome.org/gene/28377:figf ^@ http://purl.uniprot.org/uniprot/G1KMB4 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/28377:slc25a32 ^@ http://purl.uniprot.org/uniprot/G1KIX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/28377:pdgfc ^@ http://purl.uniprot.org/uniprot/G1KT70 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:capza3 ^@ http://purl.uniprot.org/uniprot/G1KU75 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/28377:manf ^@ http://purl.uniprot.org/uniprot/G1KGX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARMET family.|||Secreted http://togogenome.org/gene/28377:kif18b ^@ http://purl.uniprot.org/uniprot/G1KGP3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/28377:fgf14 ^@ http://purl.uniprot.org/uniprot/G1KBQ9 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/28377:p4ha1 ^@ http://purl.uniprot.org/uniprot/A0A803T0H2|||http://purl.uniprot.org/uniprot/G1K8Q8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/28377:tnr ^@ http://purl.uniprot.org/uniprot/G1KQK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family.|||extracellular matrix http://togogenome.org/gene/28377:tfpi2 ^@ http://purl.uniprot.org/uniprot/G1KNH2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/28377:csgalnact1 ^@ http://purl.uniprot.org/uniprot/G1KIE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/28377:ccl20 ^@ http://purl.uniprot.org/uniprot/R4G9F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/28377:nap1l4 ^@ http://purl.uniprot.org/uniprot/G1K899 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/28377:slc30a7 ^@ http://purl.uniprot.org/uniprot/G1KBI8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Functions as a zinc transporter.|||Homooligomer.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/28377:f3 ^@ http://purl.uniprot.org/uniprot/G1KDB7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tissue factor family.|||Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.|||Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. http://togogenome.org/gene/28377:gabrg1 ^@ http://purl.uniprot.org/uniprot/G1KWC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/28377:LOC100564587 ^@ http://purl.uniprot.org/uniprot/G1KX70 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/28377:LOC100556974 ^@ http://purl.uniprot.org/uniprot/G1KTP2 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/28377:LOC100567919 ^@ http://purl.uniprot.org/uniprot/G1KMX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/28377:LOC103279270 ^@ http://purl.uniprot.org/uniprot/G1KF75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.|||Secreted http://togogenome.org/gene/28377:pcmtd2 ^@ http://purl.uniprot.org/uniprot/A0A803SSB3 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/28377:f12 ^@ http://purl.uniprot.org/uniprot/G1KF85 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family. Snake venom subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:nim1k ^@ http://purl.uniprot.org/uniprot/G1KKG7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/28377:amdhd1 ^@ http://purl.uniprot.org/uniprot/A0A803TRU7|||http://purl.uniprot.org/uniprot/G1KPF4 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. HutI family. http://togogenome.org/gene/28377:galnt7 ^@ http://purl.uniprot.org/uniprot/A0A803T275|||http://purl.uniprot.org/uniprot/G1KE43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:naxd ^@ http://purl.uniprot.org/uniprot/G1KF06 ^@ Function|||Similarity ^@ Belongs to the NnrD/CARKD family.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. http://togogenome.org/gene/28377:hs2st1 ^@ http://purl.uniprot.org/uniprot/G1K9R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:slc25a15 ^@ http://purl.uniprot.org/uniprot/G1KSW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/28377:fuca2 ^@ http://purl.uniprot.org/uniprot/G1KHC4 ^@ Function|||Similarity ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family. http://togogenome.org/gene/28377:gns ^@ http://purl.uniprot.org/uniprot/G1KBV9 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Lysosome|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/28377:sft2d1 ^@ http://purl.uniprot.org/uniprot/A0A803SKY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/28377:psmb6 ^@ http://purl.uniprot.org/uniprot/G1KJL4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:hspa8 ^@ http://purl.uniprot.org/uniprot/H9G9N5 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/28377:ston2 ^@ http://purl.uniprot.org/uniprot/A0A803TGN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.|||Belongs to the Stoned B family.|||Cytoplasm|||synaptosome http://togogenome.org/gene/28377:sh3bp4 ^@ http://purl.uniprot.org/uniprot/G1KJN7 ^@ Subcellular Location Annotation ^@ Nucleus|||Vesicle|||clathrin-coated pit|||clathrin-coated vesicle http://togogenome.org/gene/28377:zdhhc5 ^@ http://purl.uniprot.org/uniprot/G1KG66 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/28377:ankzf1 ^@ http://purl.uniprot.org/uniprot/G1KND4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANKZF1/VMS1 family.|||Cytoplasm http://togogenome.org/gene/28377:dopey1 ^@ http://purl.uniprot.org/uniprot/A0A803TRJ0|||http://purl.uniprot.org/uniprot/G1KTQ9 ^@ Similarity ^@ Belongs to the dopey family. http://togogenome.org/gene/28377:nadsyn1 ^@ http://purl.uniprot.org/uniprot/G1KRU6 ^@ Similarity|||Subunit ^@ Homohexamer.|||In the C-terminal section; belongs to the NAD synthetase family. http://togogenome.org/gene/28377:aldh1a1 ^@ http://purl.uniprot.org/uniprot/G1KMC0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/28377:LOC100558604 ^@ http://purl.uniprot.org/uniprot/G1KNA9|||http://purl.uniprot.org/uniprot/R4GD94 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:abhd3 ^@ http://purl.uniprot.org/uniprot/G1KH59 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/28377:mogat1 ^@ http://purl.uniprot.org/uniprot/G1KD42 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:atp5o ^@ http://purl.uniprot.org/uniprot/G1KDI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/28377:pon2 ^@ http://purl.uniprot.org/uniprot/G1KPD0 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/28377:serpina10 ^@ http://purl.uniprot.org/uniprot/G1KCG5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/28377:ctso ^@ http://purl.uniprot.org/uniprot/G1KT79 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/28377:kif25 ^@ http://purl.uniprot.org/uniprot/A0A803T3Q0|||http://purl.uniprot.org/uniprot/G1KYN1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/28377:cd79b ^@ http://purl.uniprot.org/uniprot/A0A803TUE3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/28377:fam69a ^@ http://purl.uniprot.org/uniprot/A0A803SRJ8 ^@ Similarity ^@ Belongs to the DIPK family. http://togogenome.org/gene/28377:eif2b1 ^@ http://purl.uniprot.org/uniprot/A0A803THL1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2B alpha/beta/delta subunits family.|||Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.|||Complex of five different subunits; alpha, beta, gamma, delta and epsilon. http://togogenome.org/gene/28377:fam110c ^@ http://purl.uniprot.org/uniprot/G1KDY2 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/28377:LOC100556624 ^@ http://purl.uniprot.org/uniprot/G1KMN7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/28377:nup210 ^@ http://purl.uniprot.org/uniprot/G1KMY0 ^@ Similarity ^@ Belongs to the NUP210 family. http://togogenome.org/gene/28377:LOC100565553 ^@ http://purl.uniprot.org/uniprot/A0A803SNV0 ^@ Similarity ^@ Belongs to the TCP10 family. http://togogenome.org/gene/28377:tpp2 ^@ http://purl.uniprot.org/uniprot/G1KBP3|||http://purl.uniprot.org/uniprot/R4GC74 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/28377:kcnk17 ^@ http://purl.uniprot.org/uniprot/G1KA72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/28377:nemp2 ^@ http://purl.uniprot.org/uniprot/G1K8U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NEMP family.|||Nucleus inner membrane http://togogenome.org/gene/28377:nkx1-2 ^@ http://purl.uniprot.org/uniprot/G1KVY8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:s1pr5 ^@ http://purl.uniprot.org/uniprot/G1KS14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:steap4 ^@ http://purl.uniprot.org/uniprot/G1KRV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/28377:cntnap4 ^@ http://purl.uniprot.org/uniprot/A0A803THJ2|||http://purl.uniprot.org/uniprot/G1KSM0 ^@ Caution|||Similarity ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:smug1 ^@ http://purl.uniprot.org/uniprot/A0A803SQG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.|||Nucleus http://togogenome.org/gene/28377:wnt5b ^@ http://purl.uniprot.org/uniprot/G1K857 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/28377:sgcz ^@ http://purl.uniprot.org/uniprot/G1KE54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/28377:dzip1l ^@ http://purl.uniprot.org/uniprot/G1KIM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DZIP C2H2-type zinc-finger protein family.|||cilium basal body http://togogenome.org/gene/28377:LOC100562947 ^@ http://purl.uniprot.org/uniprot/G1KUS0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/28377:cdh5 ^@ http://purl.uniprot.org/uniprot/H9G471 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/28377:rspo2 ^@ http://purl.uniprot.org/uniprot/G1KJT8 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/28377:kcne4 ^@ http://purl.uniprot.org/uniprot/A0A803TES1 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/28377:tcp11 ^@ http://purl.uniprot.org/uniprot/G1KA00 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/28377:akap3 ^@ http://purl.uniprot.org/uniprot/G1KJ24 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/28377:LOC103279244 ^@ http://purl.uniprot.org/uniprot/G1KS08 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:rock2 ^@ http://purl.uniprot.org/uniprot/A0A803SRZ3|||http://purl.uniprot.org/uniprot/A0A803SWY4|||http://purl.uniprot.org/uniprot/A0A803TQY8|||http://purl.uniprot.org/uniprot/G1K8E0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||Membrane http://togogenome.org/gene/28377:ppara ^@ http://purl.uniprot.org/uniprot/G1KD82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/28377:rrp36 ^@ http://purl.uniprot.org/uniprot/A0A803SZ90 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with 90S and pre-40S pre-ribosomal particles.|||Belongs to the RRP36 family.|||Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.|||nucleolus http://togogenome.org/gene/28377:LOC100552069 ^@ http://purl.uniprot.org/uniprot/G1K865 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100556956 ^@ http://purl.uniprot.org/uniprot/G1KKD3 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/28377:ptch2 ^@ http://purl.uniprot.org/uniprot/G1KR57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/28377:dsel ^@ http://purl.uniprot.org/uniprot/G1KMA8 ^@ Similarity ^@ Belongs to the dermatan-sulfate isomerase family. http://togogenome.org/gene/28377:c2h17orf62 ^@ http://purl.uniprot.org/uniprot/G1KT85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYBC1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:dis3 ^@ http://purl.uniprot.org/uniprot/A0A803SWG8 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/28377:nek9 ^@ http://purl.uniprot.org/uniprot/G1KT87 ^@ Similarity ^@ Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. http://togogenome.org/gene/28377:acod1 ^@ http://purl.uniprot.org/uniprot/A0A803SUN1|||http://purl.uniprot.org/uniprot/G1KWH4 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/28377:fbxo32 ^@ http://purl.uniprot.org/uniprot/G1KJ90 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:gpr65 ^@ http://purl.uniprot.org/uniprot/G1KNM2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:grin2c ^@ http://purl.uniprot.org/uniprot/G1KEI8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/28377:tmem39a ^@ http://purl.uniprot.org/uniprot/G1KUA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/28377:LOC103278612 ^@ http://purl.uniprot.org/uniprot/G1KMY1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Golgi apparatus|||Membrane raft|||Secreted http://togogenome.org/gene/28377:LOC100558074 ^@ http://purl.uniprot.org/uniprot/G1KAU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/28377:tbc1d7 ^@ http://purl.uniprot.org/uniprot/G1KCQ7 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Vesicle http://togogenome.org/gene/28377:yme1l1 ^@ http://purl.uniprot.org/uniprot/G1KHA6 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/28377:slc26a7 ^@ http://purl.uniprot.org/uniprot/G1KBS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/28377:ube2d2 ^@ http://purl.uniprot.org/uniprot/G1KAB3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/28377:spata6l ^@ http://purl.uniprot.org/uniprot/A0A803TNY4|||http://purl.uniprot.org/uniprot/R4GC64 ^@ Similarity ^@ Belongs to the SPATA6 family. http://togogenome.org/gene/28377:siah1 ^@ http://purl.uniprot.org/uniprot/H9GL05 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/28377:tmem267 ^@ http://purl.uniprot.org/uniprot/G1KKJ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:ppil1 ^@ http://purl.uniprot.org/uniprot/G1KKA8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/28377:dpy19l4 ^@ http://purl.uniprot.org/uniprot/G1KCA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/28377:casc3 ^@ http://purl.uniprot.org/uniprot/A0A803TXR6|||http://purl.uniprot.org/uniprot/G1KB37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CASC3 family.|||Nucleus speckle|||dendrite|||perinuclear region http://togogenome.org/gene/28377:lactb2 ^@ http://purl.uniprot.org/uniprot/G1KQC0 ^@ Function|||Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability. http://togogenome.org/gene/28377:LOC103278031 ^@ http://purl.uniprot.org/uniprot/A0A803SZ65 ^@ Similarity ^@ Belongs to the HARBI1 family. http://togogenome.org/gene/28377:sirt5 ^@ http://purl.uniprot.org/uniprot/G1KC04 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sirtuin family. Class III subfamily.|||Binds 1 zinc ion per subunit.|||In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-106 and Arg-109) that bind to malonylated and succinylated substrates and define the specificity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion|||NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.|||Nucleus|||cytosol http://togogenome.org/gene/28377:sec23a ^@ http://purl.uniprot.org/uniprot/G1KRP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/28377:hnrnpa1 ^@ http://purl.uniprot.org/uniprot/A0A803TGK2|||http://purl.uniprot.org/uniprot/G1KG94 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/28377:atp2b4 ^@ http://purl.uniprot.org/uniprot/A0A803SXC7|||http://purl.uniprot.org/uniprot/A0A803TCK8|||http://purl.uniprot.org/uniprot/G1KK12 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:LOC100560655 ^@ http://purl.uniprot.org/uniprot/A0A803TKE1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space http://togogenome.org/gene/28377:pfdn1 ^@ http://purl.uniprot.org/uniprot/G1KNY0 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/28377:gpr61 ^@ http://purl.uniprot.org/uniprot/G1KKP0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:LOC100554046 ^@ http://purl.uniprot.org/uniprot/R4G9Y4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:LOC100565902 ^@ http://purl.uniprot.org/uniprot/G1KH12 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/28377:b3gnt5 ^@ http://purl.uniprot.org/uniprot/G1KGV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/28377:LOC100564988 ^@ http://purl.uniprot.org/uniprot/A0A803TGI1 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/28377:cdc14a ^@ http://purl.uniprot.org/uniprot/A0A803TZI5|||http://purl.uniprot.org/uniprot/G1KBN9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/28377:ythdc1 ^@ http://purl.uniprot.org/uniprot/A0A803SKP4|||http://purl.uniprot.org/uniprot/A0A803SZX1|||http://purl.uniprot.org/uniprot/A0A803TJN7|||http://purl.uniprot.org/uniprot/G1KJB2 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/28377:dlgap1 ^@ http://purl.uniprot.org/uniprot/A0A803T2S8|||http://purl.uniprot.org/uniprot/A0A803TUV2|||http://purl.uniprot.org/uniprot/G1KZ33 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/28377:sptssa ^@ http://purl.uniprot.org/uniprot/A0A803TJZ1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:pdxk ^@ http://purl.uniprot.org/uniprot/G1KUF2 ^@ Similarity ^@ Belongs to the pyridoxine kinase family. http://togogenome.org/gene/28377:LOC100559713 ^@ http://purl.uniprot.org/uniprot/G1KNC9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/28377:tlr7 ^@ http://purl.uniprot.org/uniprot/G1K9P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/28377:tm4sf4 ^@ http://purl.uniprot.org/uniprot/G1KGP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/28377:myh9 ^@ http://purl.uniprot.org/uniprot/G1KSP5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/28377:uhrf2 ^@ http://purl.uniprot.org/uniprot/G1KCR6 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.|||Nucleus|||The YDG domain mediates the interaction with histone H3.|||The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3). http://togogenome.org/gene/28377:med19 ^@ http://purl.uniprot.org/uniprot/G1KG31 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 19 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/28377:mtr ^@ http://purl.uniprot.org/uniprot/G1KBM2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin-B12 dependent methionine synthase family.|||Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.|||Cytoplasm|||Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin. http://togogenome.org/gene/28377:prmt7 ^@ http://purl.uniprot.org/uniprot/H9GG55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.|||Nucleus|||cytosol http://togogenome.org/gene/28377:rps19bp1 ^@ http://purl.uniprot.org/uniprot/G1KGR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AROS family.|||nucleolus http://togogenome.org/gene/28377:mtap ^@ http://purl.uniprot.org/uniprot/G1KU49 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Cytoplasm|||Homotrimer.|||Nucleus http://togogenome.org/gene/28377:pgf ^@ http://purl.uniprot.org/uniprot/A0A803SMR1|||http://purl.uniprot.org/uniprot/A0A803TL04 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/28377:exoc8 ^@ http://purl.uniprot.org/uniprot/G1KB83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EXO84 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||growth cone|||perinuclear region http://togogenome.org/gene/28377:igf2bp1 ^@ http://purl.uniprot.org/uniprot/G1KF72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||Nucleus|||filopodium|||growth cone|||lamellipodium|||perinuclear region http://togogenome.org/gene/28377:esf1 ^@ http://purl.uniprot.org/uniprot/G1K8X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF1 family.|||nucleolus http://togogenome.org/gene/28377:atp7b ^@ http://purl.uniprot.org/uniprot/G1KT84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/28377:dym ^@ http://purl.uniprot.org/uniprot/A0A803TV22|||http://purl.uniprot.org/uniprot/G1KUM3 ^@ Similarity ^@ Belongs to the dymeclin family. http://togogenome.org/gene/28377:dynlt3 ^@ http://purl.uniprot.org/uniprot/A0A803SML4 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/28377:LOC100552076 ^@ http://purl.uniprot.org/uniprot/R4G9U3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/28377:ip6k3 ^@ http://purl.uniprot.org/uniprot/A0A803TP65|||http://purl.uniprot.org/uniprot/G1KS75 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/28377:ppargc1a ^@ http://purl.uniprot.org/uniprot/G1K8Y9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:opn3 ^@ http://purl.uniprot.org/uniprot/G1KBW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/28377:mrpl23 ^@ http://purl.uniprot.org/uniprot/G1KJ71 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/28377:akr1d1 ^@ http://purl.uniprot.org/uniprot/G1KNT7 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/28377:tspan10 ^@ http://purl.uniprot.org/uniprot/G1KQN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/28377:gif ^@ http://purl.uniprot.org/uniprot/G1KJI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/28377:hoxc13 ^@ http://purl.uniprot.org/uniprot/G1KKK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/28377:alkbh8 ^@ http://purl.uniprot.org/uniprot/G1KKM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alkB family.|||Cytoplasm http://togogenome.org/gene/28377:clp1 ^@ http://purl.uniprot.org/uniprot/G1KG72 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Clp1 family. Clp1 subfamily.|||Component of the tRNA splicing endonuclease complex. Component of pre-mRNA cleavage complex II (CF-II).|||Nucleus|||Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. http://togogenome.org/gene/28377:cry1 ^@ http://purl.uniprot.org/uniprot/A0A803STD7|||http://purl.uniprot.org/uniprot/G1KQX0 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/28377:cdkn2aipnl ^@ http://purl.uniprot.org/uniprot/A0A803TK83 ^@ Similarity ^@ Belongs to the CARF family. http://togogenome.org/gene/28377:st7 ^@ http://purl.uniprot.org/uniprot/A0A803U0K8|||http://purl.uniprot.org/uniprot/G1KHG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/28377:mgmt ^@ http://purl.uniprot.org/uniprot/A0A803SV62 ^@ Function|||Similarity ^@ Belongs to the MGMT family.|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. http://togogenome.org/gene/28377:LOC100552049 ^@ http://purl.uniprot.org/uniprot/A0A803T2A8|||http://purl.uniprot.org/uniprot/A0A803T772|||http://purl.uniprot.org/uniprot/A0A803TLL0|||http://purl.uniprot.org/uniprot/G1KUP7|||http://purl.uniprot.org/uniprot/G1KUU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/28377:actr6 ^@ http://purl.uniprot.org/uniprot/G1KMN2 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/28377:chmp6 ^@ http://purl.uniprot.org/uniprot/G1KR78 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/28377:ackr3 ^@ http://purl.uniprot.org/uniprot/G1KK52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:il6 ^@ http://purl.uniprot.org/uniprot/R4GCE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/28377:gli3 ^@ http://purl.uniprot.org/uniprot/A0A803U1R2 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/28377:btg1 ^@ http://purl.uniprot.org/uniprot/A0A803TSG1 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/28377:fam83c ^@ http://purl.uniprot.org/uniprot/G1KE70 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/28377:elovl7 ^@ http://purl.uniprot.org/uniprot/G1KIC3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL7 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/28377:tns1 ^@ http://purl.uniprot.org/uniprot/A0A803TBX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/28377:cc2d1b ^@ http://purl.uniprot.org/uniprot/G1KHH0 ^@ Similarity ^@ Belongs to the CC2D1 family. http://togogenome.org/gene/28377:tmem200c ^@ http://purl.uniprot.org/uniprot/G1KJF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/28377:fam135a ^@ http://purl.uniprot.org/uniprot/G1KHT7 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/28377:usp37 ^@ http://purl.uniprot.org/uniprot/G1KAT4 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/28377:uroc1 ^@ http://purl.uniprot.org/uniprot/G1KP64 ^@ Similarity ^@ Belongs to the urocanase family. http://togogenome.org/gene/28377:pi4k2a ^@ http://purl.uniprot.org/uniprot/G1KBF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.|||Membrane http://togogenome.org/gene/28377:grik1 ^@ http://purl.uniprot.org/uniprot/A0A803SWH0|||http://purl.uniprot.org/uniprot/A0A803T2M3|||http://purl.uniprot.org/uniprot/G1KAD4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/28377:uimc1 ^@ http://purl.uniprot.org/uniprot/G1KDZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAP80 family.|||Nucleus http://togogenome.org/gene/28377:atp2b2 ^@ http://purl.uniprot.org/uniprot/A0A803T936 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:rprd1a ^@ http://purl.uniprot.org/uniprot/A0A803T197|||http://purl.uniprot.org/uniprot/G1KFS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.|||Nucleus http://togogenome.org/gene/28377:pou3f2 ^@ http://purl.uniprot.org/uniprot/G1KXS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-3 subfamily.|||Nucleus http://togogenome.org/gene/28377:tmpo ^@ http://purl.uniprot.org/uniprot/A0A803TF01|||http://purl.uniprot.org/uniprot/A0A803TYP9|||http://purl.uniprot.org/uniprot/G1KNK2 ^@ Similarity ^@ Belongs to the LEM family. http://togogenome.org/gene/28377:klhl3 ^@ http://purl.uniprot.org/uniprot/G1KTL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KLHL3 family.|||cytoskeleton|||cytosol http://togogenome.org/gene/28377:LOC100560379 ^@ http://purl.uniprot.org/uniprot/A0A803TEX0 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/28377:LOC100561485 ^@ http://purl.uniprot.org/uniprot/A0A803TQU1 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/28377:atf7 ^@ http://purl.uniprot.org/uniprot/G1K969 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members.|||Nucleus|||Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation. In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes. Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation. In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening. http://togogenome.org/gene/28377:LOC100566849 ^@ http://purl.uniprot.org/uniprot/R4GCD6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/28377:LOC100558726 ^@ http://purl.uniprot.org/uniprot/G1KZC5 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/28377:greb1l ^@ http://purl.uniprot.org/uniprot/G1KH91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GREB1 family.|||Membrane http://togogenome.org/gene/28377:fnbp1l ^@ http://purl.uniprot.org/uniprot/A0A803TNT3|||http://purl.uniprot.org/uniprot/G1KE72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNBP1 family.|||Cell membrane|||Cytoplasmic vesicle|||Membrane|||Vesicle|||cell cortex|||cytoskeleton http://togogenome.org/gene/28377:supt3h ^@ http://purl.uniprot.org/uniprot/A0A803SY65|||http://purl.uniprot.org/uniprot/G1KN25 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:kcnj15 ^@ http://purl.uniprot.org/uniprot/A0A803TU69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/28377:dpyd ^@ http://purl.uniprot.org/uniprot/A0A803TH67|||http://purl.uniprot.org/uniprot/G1KED2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the dihydropyrimidine dehydrogenase family.|||Belongs to the flavin monoamine oxidase family. FIG1 subfamily.|||Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.|||Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. http://togogenome.org/gene/28377:phb ^@ http://purl.uniprot.org/uniprot/G1KD73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Cell membrane|||Mitochondrion inner membrane http://togogenome.org/gene/28377:gjd2 ^@ http://purl.uniprot.org/uniprot/G1K942 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/28377:dram2 ^@ http://purl.uniprot.org/uniprot/R4G9P2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:LOC100553835 ^@ http://purl.uniprot.org/uniprot/G1KMK4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/28377:kiaa1324 ^@ http://purl.uniprot.org/uniprot/G1KJW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELAPOR family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:rps21 ^@ http://purl.uniprot.org/uniprot/A0A803T1Q3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the 40S small ribosomal subunit.|||Endoplasmic reticulum|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/28377:mrpl42 ^@ http://purl.uniprot.org/uniprot/G1KMI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL42 family.|||Mitochondrion http://togogenome.org/gene/28377:gkap1 ^@ http://purl.uniprot.org/uniprot/A0A803TT67 ^@ Similarity ^@ Belongs to the GKAP1 family. http://togogenome.org/gene/28377:tnfsf11 ^@ http://purl.uniprot.org/uniprot/A0A803SXH1 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/28377:actr3 ^@ http://purl.uniprot.org/uniprot/G1KB09 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/28377:stat4 ^@ http://purl.uniprot.org/uniprot/A0A803TAI1|||http://purl.uniprot.org/uniprot/A0A803TV40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:cxxc5 ^@ http://purl.uniprot.org/uniprot/A0A803TTG3|||http://purl.uniprot.org/uniprot/G1KAB6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/28377:tnfrsf21 ^@ http://purl.uniprot.org/uniprot/G1KNP9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:dnajc24 ^@ http://purl.uniprot.org/uniprot/A0A803TJA5 ^@ Similarity ^@ Belongs to the DPH4 family. http://togogenome.org/gene/28377:trpc1 ^@ http://purl.uniprot.org/uniprot/G1KD53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.|||Membrane|||Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. http://togogenome.org/gene/28377:LOC100555543 ^@ http://purl.uniprot.org/uniprot/H9GNI2 ^@ Similarity ^@ Belongs to the phosphatidylethanolamine-binding protein family. http://togogenome.org/gene/28377:atp6v0d2 ^@ http://purl.uniprot.org/uniprot/G1KJ03 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/28377:LOC100552897 ^@ http://purl.uniprot.org/uniprot/A0A803TZE7 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/28377:grb10 ^@ http://purl.uniprot.org/uniprot/G1KHW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/28377:h3f3a ^@ http://purl.uniprot.org/uniprot/G1KGC9 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/28377:ccno ^@ http://purl.uniprot.org/uniprot/G1KR21 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/28377:tmem173 ^@ http://purl.uniprot.org/uniprot/G1KAA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STING family.|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||autophagosome membrane|||perinuclear region http://togogenome.org/gene/28377:sulf2 ^@ http://purl.uniprot.org/uniprot/A0A803T8H3|||http://purl.uniprot.org/uniprot/G1KSG0 ^@ Cofactor|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Endoplasmic reticulum|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/28377:LOC103279308 ^@ http://purl.uniprot.org/uniprot/H9G8V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/28377:gfra3 ^@ http://purl.uniprot.org/uniprot/G1KFX7 ^@ Similarity ^@ Belongs to the GDNFR family. http://togogenome.org/gene/28377:aldh5a1 ^@ http://purl.uniprot.org/uniprot/G1KB06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).|||Homotetramer.|||Mitochondrion http://togogenome.org/gene/28377:smc1a ^@ http://purl.uniprot.org/uniprot/G1KJ08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/28377:ankh ^@ http://purl.uniprot.org/uniprot/G1KED7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANKH family.|||Membrane|||Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter. http://togogenome.org/gene/28377:npm1 ^@ http://purl.uniprot.org/uniprot/A0A803TXR4 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/28377:laptm4a ^@ http://purl.uniprot.org/uniprot/A0A803T9Q4|||http://purl.uniprot.org/uniprot/G1KPY6 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/28377:eps8l2 ^@ http://purl.uniprot.org/uniprot/G1KQU8 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/28377:mterf3 ^@ http://purl.uniprot.org/uniprot/G1KCK0 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/28377:terf1 ^@ http://purl.uniprot.org/uniprot/G1KPX9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.|||Homodimer.|||Nucleus http://togogenome.org/gene/28377:gnmt ^@ http://purl.uniprot.org/uniprot/G1KEE2 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. http://togogenome.org/gene/28377:LOC100552570 ^@ http://purl.uniprot.org/uniprot/G1KHZ0 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/28377:ndufaf2 ^@ http://purl.uniprot.org/uniprot/A0A803TDD4 ^@ Similarity ^@ Belongs to the complex I NDUFA12 subunit family. http://togogenome.org/gene/28377:ndc1 ^@ http://purl.uniprot.org/uniprot/G1KIA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDC1 family.|||Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.|||Membrane|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/28377:lgr6 ^@ http://purl.uniprot.org/uniprot/G1KCW5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:rapgef2 ^@ http://purl.uniprot.org/uniprot/A0A803SUD6 ^@ Similarity ^@ Belongs to the RAPGEF2 family. http://togogenome.org/gene/28377:ssh3 ^@ http://purl.uniprot.org/uniprot/G1KHA2 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/28377:phykpl ^@ http://purl.uniprot.org/uniprot/G1KTB5 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/28377:degs1 ^@ http://purl.uniprot.org/uniprot/G1KE41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:trpc3 ^@ http://purl.uniprot.org/uniprot/A0A803TJ37|||http://purl.uniprot.org/uniprot/G1KME8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:rnpc3 ^@ http://purl.uniprot.org/uniprot/G1KAA4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:fam160a1 ^@ http://purl.uniprot.org/uniprot/G1KBB6 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/28377:peli1 ^@ http://purl.uniprot.org/uniprot/A0A803U030 ^@ Similarity ^@ Belongs to the pellino family. http://togogenome.org/gene/28377:tpra1 ^@ http://purl.uniprot.org/uniprot/G1KGQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0359 family.|||Membrane http://togogenome.org/gene/28377:naa35 ^@ http://purl.uniprot.org/uniprot/G1K8P6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MAK10 family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.|||Cytoplasm http://togogenome.org/gene/28377:kcnc1 ^@ http://purl.uniprot.org/uniprot/G1K883 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:il2rb ^@ http://purl.uniprot.org/uniprot/A0A803T4P8|||http://purl.uniprot.org/uniprot/A0A803TD52 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Cell membrane|||Membrane|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. http://togogenome.org/gene/28377:hoxb9 ^@ http://purl.uniprot.org/uniprot/A0A803T461|||http://purl.uniprot.org/uniprot/A0A803TE50|||http://purl.uniprot.org/uniprot/A0A803TQC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/28377:stt3b ^@ http://purl.uniprot.org/uniprot/G1KPY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/28377:tek ^@ http://purl.uniprot.org/uniprot/G1KU09 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:grk2 ^@ http://purl.uniprot.org/uniprot/G1KH29 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/28377:hcn1 ^@ http://purl.uniprot.org/uniprot/G1KL10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel HCN family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:sept8 ^@ http://purl.uniprot.org/uniprot/G1KN43 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/28377:LOC100557088 ^@ http://purl.uniprot.org/uniprot/G1KYZ2 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/28377:gng4 ^@ http://purl.uniprot.org/uniprot/G1K9Q7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/28377:st6gal2 ^@ http://purl.uniprot.org/uniprot/E4ZFG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/28377:map1lc3c ^@ http://purl.uniprot.org/uniprot/A0A803TLH6 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/28377:pex2 ^@ http://purl.uniprot.org/uniprot/G1KNL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/28377:LOC100564771 ^@ http://purl.uniprot.org/uniprot/A0A803SPU4 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/28377:tmem150c ^@ http://purl.uniprot.org/uniprot/A0A803U1L5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:dag1 ^@ http://purl.uniprot.org/uniprot/A0A803SP95 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.|||Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.|||cytoskeleton|||extracellular space|||nucleoplasm|||sarcolemma http://togogenome.org/gene/28377:nr1h3 ^@ http://purl.uniprot.org/uniprot/G1KBE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/28377:LOC100554951 ^@ http://purl.uniprot.org/uniprot/G1KNM9 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/28377:msh3 ^@ http://purl.uniprot.org/uniprot/G1KKD1 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR). http://togogenome.org/gene/28377:LOC100553421 ^@ http://purl.uniprot.org/uniprot/G1K9Q4 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/28377:isy1 ^@ http://purl.uniprot.org/uniprot/G1KNC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ISY1 family.|||Nucleus http://togogenome.org/gene/28377:LOC100552047 ^@ http://purl.uniprot.org/uniprot/G1KGT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100553899 ^@ http://purl.uniprot.org/uniprot/G1KUB8 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasmic vesicle membrane|||Interacts with ARF6.|||Membrane|||Presynapse http://togogenome.org/gene/28377:trhr ^@ http://purl.uniprot.org/uniprot/G1KK31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/28377:tmem41b ^@ http://purl.uniprot.org/uniprot/G1KJ13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/28377:LOC100554401 ^@ http://purl.uniprot.org/uniprot/G1KKC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/28377:tbp ^@ http://purl.uniprot.org/uniprot/G1KAY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/28377:adgrl1 ^@ http://purl.uniprot.org/uniprot/A0A803SQ51|||http://purl.uniprot.org/uniprot/A0A803T4Y7|||http://purl.uniprot.org/uniprot/G1KL00 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:tmem106a ^@ http://purl.uniprot.org/uniprot/G1KNJ9 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/28377:picalm ^@ http://purl.uniprot.org/uniprot/A0A803T6K3|||http://purl.uniprot.org/uniprot/A0A803TMT4 ^@ Similarity ^@ Belongs to the PICALM/SNAP91 family. http://togogenome.org/gene/28377:cav2 ^@ http://purl.uniprot.org/uniprot/A0A803SS16 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/28377:sts ^@ http://purl.uniprot.org/uniprot/A0A803TTR6|||http://purl.uniprot.org/uniprot/G1K8G6 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/28377:uba1 ^@ http://purl.uniprot.org/uniprot/G1KE14 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/28377:eif6 ^@ http://purl.uniprot.org/uniprot/G1KE62 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/28377:dtx4 ^@ http://purl.uniprot.org/uniprot/G1KFR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/28377:kat2b ^@ http://purl.uniprot.org/uniprot/G1K850 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. GCN5 subfamily.|||Nucleus|||centrosome http://togogenome.org/gene/28377:pabpc1l ^@ http://purl.uniprot.org/uniprot/G1KLR8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/28377:ins ^@ http://purl.uniprot.org/uniprot/G1KJA0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.|||Secreted http://togogenome.org/gene/28377:leprot ^@ http://purl.uniprot.org/uniprot/G1KIC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/28377:bdkrb2 ^@ http://purl.uniprot.org/uniprot/G1KNH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.|||Membrane|||Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/28377:htt ^@ http://purl.uniprot.org/uniprot/A0A803SPD1|||http://purl.uniprot.org/uniprot/G1KE86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the huntingtin family.|||Cytoplasm|||May play a role in microtubule-mediated transport or vesicle function.|||Nucleus http://togogenome.org/gene/28377:immt ^@ http://purl.uniprot.org/uniprot/A0A803TAX1|||http://purl.uniprot.org/uniprot/G1KLN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic60 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/28377:mcu ^@ http://purl.uniprot.org/uniprot/G1K8V1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCU (TC 1.A.77) family.|||Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).|||Membrane|||Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.|||Mitochondrion inner membrane http://togogenome.org/gene/28377:cer1 ^@ http://purl.uniprot.org/uniprot/G1KUD8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:dck ^@ http://purl.uniprot.org/uniprot/G1KN26 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/28377:osbpl7 ^@ http://purl.uniprot.org/uniprot/G1KG14 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/28377:grin3a ^@ http://purl.uniprot.org/uniprot/G1KKS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/28377:bpnt1 ^@ http://purl.uniprot.org/uniprot/G1K9J6 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/28377:atp23 ^@ http://purl.uniprot.org/uniprot/G1K9M9 ^@ Similarity ^@ Belongs to the peptidase M76 family. http://togogenome.org/gene/28377:ndufs6 ^@ http://purl.uniprot.org/uniprot/A0A803TY25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS6 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/28377:amotl1 ^@ http://purl.uniprot.org/uniprot/A0A803T240|||http://purl.uniprot.org/uniprot/G1KPF3 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/28377:LOC100554364 ^@ http://purl.uniprot.org/uniprot/R4GCN4 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/28377:abcd3 ^@ http://purl.uniprot.org/uniprot/G1KDK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/28377:LOC100564196 ^@ http://purl.uniprot.org/uniprot/G1KWG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.|||Membrane http://togogenome.org/gene/28377:brca1 ^@ http://purl.uniprot.org/uniprot/G1KNQ4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/28377:LOC100566080 ^@ http://purl.uniprot.org/uniprot/G1KFV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:gfm1 ^@ http://purl.uniprot.org/uniprot/G1KFW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.|||Mitochondrion http://togogenome.org/gene/28377:hdac2 ^@ http://purl.uniprot.org/uniprot/G1KM32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/28377:asz1 ^@ http://purl.uniprot.org/uniprot/G1KHF2 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with DDX4, PIWIL1, RANBP9 and TDRD1. http://togogenome.org/gene/28377:synj2 ^@ http://purl.uniprot.org/uniprot/G1KDF1 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/28377:stat3 ^@ http://purl.uniprot.org/uniprot/G1KUK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/28377:kcnk2 ^@ http://purl.uniprot.org/uniprot/A0A803T5V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/28377:LOC100553834 ^@ http://purl.uniprot.org/uniprot/A0A803U023 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/28377:slc41a2 ^@ http://purl.uniprot.org/uniprot/G1KRT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/28377:qtrt2 ^@ http://purl.uniprot.org/uniprot/G1KJG7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.|||Mitochondrion outer membrane|||Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). http://togogenome.org/gene/28377:ppp2r5e ^@ http://purl.uniprot.org/uniprot/A0A803SLS6|||http://purl.uniprot.org/uniprot/G1KS59 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family. http://togogenome.org/gene/28377:ttc27 ^@ http://purl.uniprot.org/uniprot/A0A803SQ39 ^@ Similarity ^@ Belongs to the TTC27 family. http://togogenome.org/gene/28377:tiprl ^@ http://purl.uniprot.org/uniprot/G1KKH2 ^@ Similarity ^@ Belongs to the TIP41 family. http://togogenome.org/gene/28377:mfsd10 ^@ http://purl.uniprot.org/uniprot/G1KVQ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:eif1ax ^@ http://purl.uniprot.org/uniprot/G1KML8 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. http://togogenome.org/gene/28377:kcnh4 ^@ http://purl.uniprot.org/uniprot/G1KUL0 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/28377:LOC100567311 ^@ http://purl.uniprot.org/uniprot/G1KML6 ^@ Function ^@ Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/28377:ubr1 ^@ http://purl.uniprot.org/uniprot/G1KRV4 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/28377:mcm3 ^@ http://purl.uniprot.org/uniprot/G1KDS7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/28377:slc19a1 ^@ http://purl.uniprot.org/uniprot/G1KK60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Membrane http://togogenome.org/gene/28377:tatdn3 ^@ http://purl.uniprot.org/uniprot/G1KF93 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/28377:rbm22 ^@ http://purl.uniprot.org/uniprot/G1KQA8 ^@ Similarity ^@ Belongs to the SLT11 family. http://togogenome.org/gene/28377:ptprb ^@ http://purl.uniprot.org/uniprot/A0A803TW57 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. http://togogenome.org/gene/28377:vip ^@ http://purl.uniprot.org/uniprot/G1KEE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/28377:LOC103279306 ^@ http://purl.uniprot.org/uniprot/A0A803TFB1 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/28377:nhej1 ^@ http://purl.uniprot.org/uniprot/G1KBL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XLF subfamily.|||Nucleus http://togogenome.org/gene/28377:scn4a ^@ http://purl.uniprot.org/uniprot/G1KMZ7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/28377:krr1 ^@ http://purl.uniprot.org/uniprot/G1KH40 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KRR1 family.|||Component of the ribosomal small subunit (SSU) processome.|||Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.|||nucleolus http://togogenome.org/gene/28377:prps2 ^@ http://purl.uniprot.org/uniprot/G1K9N8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/28377:cct8 ^@ http://purl.uniprot.org/uniprot/A0A803T8A4|||http://purl.uniprot.org/uniprot/G1KA10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||cilium basal body http://togogenome.org/gene/28377:ap1s2 ^@ http://purl.uniprot.org/uniprot/A0A803SZX3|||http://purl.uniprot.org/uniprot/A0A803TFE5|||http://purl.uniprot.org/uniprot/G1KTG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||clathrin-coated pit http://togogenome.org/gene/28377:nhs ^@ http://purl.uniprot.org/uniprot/G1KLB0 ^@ Similarity ^@ Belongs to the NHS family. http://togogenome.org/gene/28377:nusap1 ^@ http://purl.uniprot.org/uniprot/G1KC67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NUSAP family.|||Cytoplasm http://togogenome.org/gene/28377:adprm ^@ http://purl.uniprot.org/uniprot/G1KTX6 ^@ Similarity|||Subunit ^@ Belongs to the ADPRibase-Mn family.|||Monomer. http://togogenome.org/gene/28377:dync1i1 ^@ http://purl.uniprot.org/uniprot/A0A803SN77|||http://purl.uniprot.org/uniprot/G1KQ03 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/28377:atp2b3 ^@ http://purl.uniprot.org/uniprot/A0A803U024|||http://purl.uniprot.org/uniprot/G1KJ35 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:LOC100567117 ^@ http://purl.uniprot.org/uniprot/G1KII4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:vgll2 ^@ http://purl.uniprot.org/uniprot/G1KPN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||Nucleus http://togogenome.org/gene/28377:tradd ^@ http://purl.uniprot.org/uniprot/G1KXS9 ^@ Subcellular Location Annotation ^@ Nucleus|||cytoskeleton http://togogenome.org/gene/28377:pex1 ^@ http://purl.uniprot.org/uniprot/G1KR45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||cytosol http://togogenome.org/gene/28377:LOC103278531 ^@ http://purl.uniprot.org/uniprot/A0A803TAG2 ^@ Similarity ^@ Belongs to the HARBI1 family. http://togogenome.org/gene/28377:scarb2 ^@ http://purl.uniprot.org/uniprot/G1KMI7 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/28377:LOC100556452 ^@ http://purl.uniprot.org/uniprot/R4GBW3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/28377:ubr2 ^@ http://purl.uniprot.org/uniprot/G1K908 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/28377:ipo7 ^@ http://purl.uniprot.org/uniprot/G1KIZ4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/28377:cacna2d3 ^@ http://purl.uniprot.org/uniprot/A0A803TMZ1|||http://purl.uniprot.org/uniprot/G1KLR0 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/28377:emc3 ^@ http://purl.uniprot.org/uniprot/A0A803THP1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/28377:gpr182 ^@ http://purl.uniprot.org/uniprot/G1KGG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:lig4 ^@ http://purl.uniprot.org/uniprot/G1KPZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/28377:prss16 ^@ http://purl.uniprot.org/uniprot/H9GHB0 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/28377:c3h2orf49 ^@ http://purl.uniprot.org/uniprot/A0A803TVW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ashwin family.|||Nucleus http://togogenome.org/gene/28377:vgll3 ^@ http://purl.uniprot.org/uniprot/G1KP20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs.|||Nucleus http://togogenome.org/gene/28377:avl9 ^@ http://purl.uniprot.org/uniprot/G1KIZ5 ^@ Subcellular Location Annotation ^@ Recycling endosome http://togogenome.org/gene/28377:LOC100568179 ^@ http://purl.uniprot.org/uniprot/A0A803SVA9 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/28377:susd1 ^@ http://purl.uniprot.org/uniprot/A0A803SKM7|||http://purl.uniprot.org/uniprot/G1KYE4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:LOC100554808 ^@ http://purl.uniprot.org/uniprot/A0A803SRW6 ^@ Similarity ^@ Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily. http://togogenome.org/gene/28377:glra3 ^@ http://purl.uniprot.org/uniprot/G1KEG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/28377:rsad2 ^@ http://purl.uniprot.org/uniprot/A0A803TRZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RSAD2 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:tmem242 ^@ http://purl.uniprot.org/uniprot/R4GC78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM242 family.|||Membrane http://togogenome.org/gene/28377:gabra2 ^@ http://purl.uniprot.org/uniprot/G1KG07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/28377:ccdc53 ^@ http://purl.uniprot.org/uniprot/A0A803TE02 ^@ Similarity ^@ Belongs to the CCDC53 family. http://togogenome.org/gene/28377:kcnk12 ^@ http://purl.uniprot.org/uniprot/G1KPF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/28377:mon1b ^@ http://purl.uniprot.org/uniprot/G1KEY9 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/28377:fam163a ^@ http://purl.uniprot.org/uniprot/A0A803TL05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/28377:eif2s2 ^@ http://purl.uniprot.org/uniprot/A0A803TTC2 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/28377:LOC100557356 ^@ http://purl.uniprot.org/uniprot/G1KK17 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:LOC100553289 ^@ http://purl.uniprot.org/uniprot/A0A803TJ75 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/28377:sgsh ^@ http://purl.uniprot.org/uniprot/G1KRH7 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/28377:cdc5l ^@ http://purl.uniprot.org/uniprot/G1KMZ5 ^@ Similarity ^@ Belongs to the CEF1 family. http://togogenome.org/gene/28377:plppr1 ^@ http://purl.uniprot.org/uniprot/G1KTW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/28377:lix1 ^@ http://purl.uniprot.org/uniprot/G1KLQ5 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/28377:LOC100554852 ^@ http://purl.uniprot.org/uniprot/G1KSJ6 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/28377:usp1 ^@ http://purl.uniprot.org/uniprot/G1KH47 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/28377:c3h11orf70 ^@ http://purl.uniprot.org/uniprot/G1KMT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP300 family.|||Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.|||Cytoplasm http://togogenome.org/gene/28377:gorasp1 ^@ http://purl.uniprot.org/uniprot/G1KJ15 ^@ Similarity ^@ Belongs to the GORASP family. http://togogenome.org/gene/28377:LOC100556245 ^@ http://purl.uniprot.org/uniprot/G1K8A9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/28377:ednrb ^@ http://purl.uniprot.org/uniprot/A0A803T6S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100566807 ^@ http://purl.uniprot.org/uniprot/A0A803TR52 ^@ Similarity ^@ Belongs to the osteocalcin/matrix Gla protein family. http://togogenome.org/gene/28377:ccdc126 ^@ http://purl.uniprot.org/uniprot/A0A803TA74 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/28377:tmcc3 ^@ http://purl.uniprot.org/uniprot/A0A803T1D6|||http://purl.uniprot.org/uniprot/A0A803TJ60|||http://purl.uniprot.org/uniprot/G1KMQ8 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/28377:LOC100555334 ^@ http://purl.uniprot.org/uniprot/G1KNY2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/28377:scube3 ^@ http://purl.uniprot.org/uniprot/A0A803TAJ7|||http://purl.uniprot.org/uniprot/G1KA86 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:c1h14orf1 ^@ http://purl.uniprot.org/uniprot/A0A803TRX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG28 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28377:thbs2 ^@ http://purl.uniprot.org/uniprot/G1KBH7 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:dlx6 ^@ http://purl.uniprot.org/uniprot/G1KQ69 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:nkain4 ^@ http://purl.uniprot.org/uniprot/G1KXT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:LOC100558850 ^@ http://purl.uniprot.org/uniprot/A0A803TA47 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/28377:rag2 ^@ http://purl.uniprot.org/uniprot/G1KDJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAG2 family.|||Nucleus http://togogenome.org/gene/28377:grm2 ^@ http://purl.uniprot.org/uniprot/G1KL62 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.|||Interacts with TAMALIN.|||Membrane http://togogenome.org/gene/28377:qsox1 ^@ http://purl.uniprot.org/uniprot/G1K901 ^@ Function|||Similarity ^@ Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.|||Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. http://togogenome.org/gene/28377:c8b ^@ http://purl.uniprot.org/uniprot/A0A803SQ81|||http://purl.uniprot.org/uniprot/G1KFX8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:phactr1 ^@ http://purl.uniprot.org/uniprot/A0A803T8F1|||http://purl.uniprot.org/uniprot/G1KCS1 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/28377:hacd4 ^@ http://purl.uniprot.org/uniprot/R4GA96 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:kdelc1 ^@ http://purl.uniprot.org/uniprot/G1KBB5 ^@ Similarity ^@ Belongs to the KDELC family. http://togogenome.org/gene/28377:slc43a1 ^@ http://purl.uniprot.org/uniprot/G1KGB8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:hoxb4 ^@ http://purl.uniprot.org/uniprot/G1KFF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/28377:fzd1 ^@ http://purl.uniprot.org/uniprot/G1KRK4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/28377:slc15a2 ^@ http://purl.uniprot.org/uniprot/A0A803SVT4|||http://purl.uniprot.org/uniprot/G1KDE4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/28377:rhbdd1 ^@ http://purl.uniprot.org/uniprot/G1KC94 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:dennd6a ^@ http://purl.uniprot.org/uniprot/G1KBG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND6 family.|||Recycling endosome http://togogenome.org/gene/28377:LOC100563146 ^@ http://purl.uniprot.org/uniprot/A0A803T5K6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hcp beta-lactamase family.|||Mitochondrion intermembrane space|||Required for assembly of mitochondrial respiratory chain complexes. http://togogenome.org/gene/28377:rragd ^@ http://purl.uniprot.org/uniprot/G1KPY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/28377:taf1d ^@ http://purl.uniprot.org/uniprot/G1KQ11 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.|||Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.|||Nucleus http://togogenome.org/gene/28377:hapln1 ^@ http://purl.uniprot.org/uniprot/G1KL49 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/28377:cbfb ^@ http://purl.uniprot.org/uniprot/G1KNE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF-beta family.|||Nucleus http://togogenome.org/gene/28377:adamts5 ^@ http://purl.uniprot.org/uniprot/G1KPY2 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/28377:pias2 ^@ http://purl.uniprot.org/uniprot/G1KM13 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/28377:cct5 ^@ http://purl.uniprot.org/uniprot/G1KK81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/28377:hsp90b1 ^@ http://purl.uniprot.org/uniprot/G1KSD1 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/28377:mcm10 ^@ http://purl.uniprot.org/uniprot/G1K9B5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM10 family.|||Nucleus http://togogenome.org/gene/28377:cd14 ^@ http://purl.uniprot.org/uniprot/G1KN28 ^@ Subcellular Location Annotation ^@ Cell membrane|||Golgi apparatus|||Membrane raft|||Secreted http://togogenome.org/gene/28377:nipa2 ^@ http://purl.uniprot.org/uniprot/G1KMN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/28377:aspn ^@ http://purl.uniprot.org/uniprot/G1KII0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||extracellular matrix http://togogenome.org/gene/28377:ormdl1 ^@ http://purl.uniprot.org/uniprot/G1KPR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/28377:pkp3 ^@ http://purl.uniprot.org/uniprot/G1KNU2 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/28377:pcyox1l ^@ http://purl.uniprot.org/uniprot/G1KRC4 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. FIG1 subfamily.|||Belongs to the prenylcysteine oxidase family. http://togogenome.org/gene/28377:osbpl11 ^@ http://purl.uniprot.org/uniprot/A0A803TJJ7 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/28377:dnase1l3 ^@ http://purl.uniprot.org/uniprot/G1KA37 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/28377:npy2r ^@ http://purl.uniprot.org/uniprot/G1KR99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/28377:tjap1 ^@ http://purl.uniprot.org/uniprot/G1KJ48 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:sostdc1 ^@ http://purl.uniprot.org/uniprot/A0A803T8H7 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:dmap1 ^@ http://purl.uniprot.org/uniprot/G1KQ81 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28377:alkbh1 ^@ http://purl.uniprot.org/uniprot/G1KTP7 ^@ Cofactor ^@ Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/28377:tspan7 ^@ http://purl.uniprot.org/uniprot/G1KQ24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/28377:ubl3 ^@ http://purl.uniprot.org/uniprot/G1KEN4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/28377:enkur ^@ http://purl.uniprot.org/uniprot/G1KHX8 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/28377:armc1 ^@ http://purl.uniprot.org/uniprot/G1KT37 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/28377:b4galt5 ^@ http://purl.uniprot.org/uniprot/G1KRN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/28377:ptar1 ^@ http://purl.uniprot.org/uniprot/G1KVH4 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/28377:tmem115 ^@ http://purl.uniprot.org/uniprot/G1KG08 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:txnrd3 ^@ http://purl.uniprot.org/uniprot/G1KPH0 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Belongs to the flavin monoamine oxidase family. FIG1 subfamily. http://togogenome.org/gene/28377:LOC100553373 ^@ http://purl.uniprot.org/uniprot/A0A803T3A9 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/28377:sdpr ^@ http://purl.uniprot.org/uniprot/A0A803TEC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/28377:LOC100564432 ^@ http://purl.uniprot.org/uniprot/R4GDE7 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/28377:gas6 ^@ http://purl.uniprot.org/uniprot/A0A803T8U3|||http://purl.uniprot.org/uniprot/A0A803TIR2|||http://purl.uniprot.org/uniprot/G1K8T5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/28377:ndufv1 ^@ http://purl.uniprot.org/uniprot/G1KJW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 51 kDa subunit family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/28377:ccnt1 ^@ http://purl.uniprot.org/uniprot/G1KI49 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/28377:bnip1 ^@ http://purl.uniprot.org/uniprot/G1KQQ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28377:LOC100552765 ^@ http://purl.uniprot.org/uniprot/R4GCL6 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/28377:cldn18 ^@ http://purl.uniprot.org/uniprot/G1KIJ7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/28377:zar1l ^@ http://purl.uniprot.org/uniprot/G1KCY1 ^@ Similarity ^@ Belongs to the ZAR1 family. http://togogenome.org/gene/28377:LOC100561433 ^@ http://purl.uniprot.org/uniprot/G1KMJ3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/28377:spx ^@ http://purl.uniprot.org/uniprot/R4GAW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spexin family.|||Secreted http://togogenome.org/gene/28377:ppp4r3b ^@ http://purl.uniprot.org/uniprot/G1KC48 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/28377:pfkfb1 ^@ http://purl.uniprot.org/uniprot/A0A803TQ15|||http://purl.uniprot.org/uniprot/G1KLB3 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/28377:plcg2 ^@ http://purl.uniprot.org/uniprot/A0A803SVM1|||http://purl.uniprot.org/uniprot/H9GF62 ^@ Function ^@ Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. http://togogenome.org/gene/28377:fam83f ^@ http://purl.uniprot.org/uniprot/G1KGI1 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/28377:psmd3 ^@ http://purl.uniprot.org/uniprot/G1KBP6 ^@ Similarity ^@ Belongs to the proteasome subunit S3 family.