http://togogenome.org/gene/28985:KLLA0_F25476g ^@ http://purl.uniprot.org/uniprot/A0A5P2TYH2 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/28985:KLLA0_F12760g ^@ http://purl.uniprot.org/uniprot/Q875L9 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/28985:KLLA0_E06271g ^@ http://purl.uniprot.org/uniprot/Q874T5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/28985:KLLA0_A03553g ^@ http://purl.uniprot.org/uniprot/A0A5P2U1J9 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/28985:KLLA0_B07601g ^@ http://purl.uniprot.org/uniprot/A0A5P2U904 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/28985:KLLA0_C07975g ^@ http://purl.uniprot.org/uniprot/A0A5P2U3K3 ^@ Function|||Similarity ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. http://togogenome.org/gene/28985:KLLA0_E22331g ^@ http://purl.uniprot.org/uniprot/A0A5P2U920 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/28985:KLLA0_D03608g ^@ http://purl.uniprot.org/uniprot/A0A5P2U4Z3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.|||Cytoplasm|||Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.|||Monomer. http://togogenome.org/gene/28985:KLLA0_D08305g ^@ http://purl.uniprot.org/uniprot/A0A5P2UAD9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS3 family. http://togogenome.org/gene/28985:KLLA0_E08251g ^@ http://purl.uniprot.org/uniprot/A0A5P2UBC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Membrane http://togogenome.org/gene/28985:KLLA0_E09021g ^@ http://purl.uniprot.org/uniprot/Q8NJ22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/28985:KLLA0_D13574g ^@ http://purl.uniprot.org/uniprot/A0A5P2UB91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMA20 family.|||Cytoplasm|||Involved in translation. http://togogenome.org/gene/28985:KLLA0_B07139g ^@ http://purl.uniprot.org/uniprot/A0A5P2U925 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/28985:KLLA0_D03696g ^@ http://purl.uniprot.org/uniprot/A0A5P2U4Z5 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/28985:KLLA0_D13662g ^@ http://purl.uniprot.org/uniprot/Q70KY5 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/28985:KLLA0_E06997g ^@ http://purl.uniprot.org/uniprot/A0A5P2UCE7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/28985:KLLA0_E11859g ^@ http://purl.uniprot.org/uniprot/A0A5P2UAV8 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/28985:KLLA0_D03234g ^@ http://purl.uniprot.org/uniprot/A0A5P2U5R7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/28985:KLLA0_E22001g ^@ http://purl.uniprot.org/uniprot/Q875M0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/28985:KLLA0_E06535g ^@ http://purl.uniprot.org/uniprot/A0A5P2UJC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||Golgi apparatus membrane|||Membrane|||Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex. http://togogenome.org/gene/28985:KLLA0_C08503g ^@ http://purl.uniprot.org/uniprot/A0A5P2U3I3 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/28985:KLLA0_F08349g ^@ http://purl.uniprot.org/uniprot/A0A5P2U1B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL43 family.|||Mitochondrion http://togogenome.org/gene/28985:KLLA0_F16797g ^@ http://purl.uniprot.org/uniprot/A0A5P2UAF3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28985:KLLA0_D12342g ^@ http://purl.uniprot.org/uniprot/A0A2I8B2F7 ^@ Similarity|||Subunit ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.|||Homotetramer. http://togogenome.org/gene/28985:KLLA0_D06787g ^@ http://purl.uniprot.org/uniprot/Q9Y7B8 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/28985:KLLA0_F03014g ^@ http://purl.uniprot.org/uniprot/A0A5P2U0K6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit C family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/28985:KLLA0_C04809g ^@ http://purl.uniprot.org/uniprot/A0A5P2U3Y2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS30 family. http://togogenome.org/gene/28985:KLLA0_D05709g ^@ http://purl.uniprot.org/uniprot/Q874T8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/28985:KLLA0_C17776g ^@ http://purl.uniprot.org/uniprot/A0A5P2U9T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RAD3/XPD subfamily.|||Nucleus http://togogenome.org/gene/28985:KLLA0_B09790g ^@ http://purl.uniprot.org/uniprot/A0A5P2UGN2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/28985:KLLA0_F08657g ^@ http://purl.uniprot.org/uniprot/A0A5P2U8T7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL20 family. http://togogenome.org/gene/28985:KLLA0_B00869g ^@ http://purl.uniprot.org/uniprot/A0A5P2UAK5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/28985:KLLA0_E16281g ^@ http://purl.uniprot.org/uniprot/Q875M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.|||Membrane http://togogenome.org/gene/28985:KLLA0_E05039g ^@ http://purl.uniprot.org/uniprot/A0A5P2UGZ1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/28985:KLLA0_F12210g ^@ http://purl.uniprot.org/uniprot/A0A5P2U2T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.|||Cytoplasm http://togogenome.org/gene/28985:KLLA0_F02035g ^@ http://purl.uniprot.org/uniprot/A0A5P2U1H6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL41 family.|||Mitochondrion http://togogenome.org/gene/28985:KLLA0_F11770g ^@ http://purl.uniprot.org/uniprot/F2Z5X5 ^@ Similarity|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Homodimer. http://togogenome.org/gene/28985:KLLA0_F05225g ^@ http://purl.uniprot.org/uniprot/A0A5P2U0V9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/28985:KLLA0_F15103g ^@ http://purl.uniprot.org/uniprot/A0A5P2UIH3 ^@ Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family. http://togogenome.org/gene/28985:KLLA0_D11682g ^@ http://purl.uniprot.org/uniprot/A0A5P2U5W4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SGF11 family.|||Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with SGF73, SUS1 and UBP8.|||Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). Involved in transcriptional regulation of a subset of SAGA-regulated genes. Within the SAGA complex, participates in a subcomplex, that specifically deubiquitinates histones H2B.|||Nucleus|||The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of UBP8 forms the 'catalytic lobe' of the SAGA deubiquitination module.|||The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module. http://togogenome.org/gene/28985:KLLA0_A00198g ^@ http://purl.uniprot.org/uniprot/A0A5P2U1U6 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THI4 family.|||Binds 1 Fe cation per subunit.|||Cytoplasm|||During the catalytic reaction, a sulfide is transferred from Cys-203 to a reaction intermediate, generating a dehydroalanine residue.|||Homooctamer.|||Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.|||Nucleus http://togogenome.org/gene/28985:KLLA0_E02355g ^@ http://purl.uniprot.org/uniprot/A0A5P2UEF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Membrane http://togogenome.org/gene/28985:KLLA0_E10099g ^@ http://purl.uniprot.org/uniprot/A0A5P2UDG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/28985:KLLA0_C06358g ^@ http://purl.uniprot.org/uniprot/A0A5P2U3S4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Component of the GSE complex.|||GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions. http://togogenome.org/gene/28985:KLLA0_C15917g ^@ http://purl.uniprot.org/uniprot/A0A5P2U515 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.|||Vacuole membrane http://togogenome.org/gene/28985:KLLA0_E17623g ^@ http://purl.uniprot.org/uniprot/A0A5P2U8W2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H3 family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/28985:KLLA0_C11869g ^@ http://purl.uniprot.org/uniprot/A0A5P2UAQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Golgi apparatus membrane|||Golgi membrane protein involved in vesicular trafficking.|||Membrane http://togogenome.org/gene/28985:KLLA0_B08173g ^@ http://purl.uniprot.org/uniprot/A0A5P2U8X6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/28985:KLLA0_F06963g ^@ http://purl.uniprot.org/uniprot/A0A5P2U281 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS19 family. http://togogenome.org/gene/28985:KLLA0_B08954g ^@ http://purl.uniprot.org/uniprot/A0A5P2U8T8 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/28985:KLLA0_D11924g ^@ http://purl.uniprot.org/uniprot/A0A5P2UDN8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAC-beta family.|||Cytoplasm|||Nucleus|||Part of the nascent polypeptide-associated complex (NAC). http://togogenome.org/gene/28985:KLLA0_C00550g ^@ http://purl.uniprot.org/uniprot/A0A5P2U8P9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic10 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/28985:KLLA0_E06447g ^@ http://purl.uniprot.org/uniprot/Q8J213 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. http://togogenome.org/gene/28985:KLLA0_E10781g ^@ http://purl.uniprot.org/uniprot/A0A5P2UDD6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CGR1 family.|||Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.|||nucleolus http://togogenome.org/gene/28985:KLLA0_D02508g ^@ http://purl.uniprot.org/uniprot/Q9URS6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/28985:KLLA0_E18525g ^@ http://purl.uniprot.org/uniprot/A0A5P2UA22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP18 family.|||Golgi apparatus membrane|||Golgi membrane protein involved in vesicular trafficking.|||Membrane http://togogenome.org/gene/28985:KLLA0_E14037g ^@ http://purl.uniprot.org/uniprot/A0A5P2UDD2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/28985:KLLA0_E20945g ^@ http://purl.uniprot.org/uniprot/Q7Z8R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/28985:KLLA0_E10209g ^@ http://purl.uniprot.org/uniprot/A0A5P2UGA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/28985:KLLA0_D16071g ^@ http://purl.uniprot.org/uniprot/A0A5P2U7F9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL29 family. http://togogenome.org/gene/28985:KLLA0_D19041g ^@ http://purl.uniprot.org/uniprot/A0A5P2UB38 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/28985:KLLA0_A05863g ^@ http://purl.uniprot.org/uniprot/A0A5P2U4E1 ^@ Cofactor|||Similarity ^@ Belongs to the radical SAM superfamily. Biotin synthase family.|||Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/28985:KLLA0_E17601g ^@ http://purl.uniprot.org/uniprot/A0A5P2UC44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/28985:KLLA0_B05621g ^@ http://purl.uniprot.org/uniprot/A0A5P2UBE4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28985:KLLA0_F21010g ^@ http://purl.uniprot.org/uniprot/A0A5P2TZW1 ^@ Similarity|||Subunit ^@ Belongs to the zinc-containing alcohol dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/28985:KLLA0_B06182g ^@ http://purl.uniprot.org/uniprot/A0A5P2UH41 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/28985:KLLA0_F21692g ^@ http://purl.uniprot.org/uniprot/Q96WM8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28985:KLLA0_A05093g ^@ http://purl.uniprot.org/uniprot/A0A5P2TZG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1A family.|||Nucleus|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. http://togogenome.org/gene/28985:KLLA0_F08921g ^@ http://purl.uniprot.org/uniprot/A0A5P2U2G5 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/28985:KLLA0_E02619g ^@ http://purl.uniprot.org/uniprot/A0A5P2UCZ2 ^@ Similarity ^@ Belongs to the complex I LYR family. SDHAF1 subfamily. http://togogenome.org/gene/28985:KLLA0_D10417g ^@ http://purl.uniprot.org/uniprot/Q9P8E2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28985:KLLA0_E10869g ^@ http://purl.uniprot.org/uniprot/A0A5P2UD83 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/28985:KLLA0_A05841g ^@ http://purl.uniprot.org/uniprot/A0A5P2TZE0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/28985:KLLA0_B13365g ^@ http://purl.uniprot.org/uniprot/A0A5P2U640 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family. http://togogenome.org/gene/28985:KLLA0_C06787g ^@ http://purl.uniprot.org/uniprot/A0A5P2U5H1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/28985:KLLA0_F13332g ^@ http://purl.uniprot.org/uniprot/A0A5P2U7T5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/28985:KLLA0_F05005g ^@ http://purl.uniprot.org/uniprot/A0A5P2U0V0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. http://togogenome.org/gene/28985:KLLA0_A05951g ^@ http://purl.uniprot.org/uniprot/A0A5P2U0F5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIE beta subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.|||Tetramer of two alpha and two beta chains. http://togogenome.org/gene/28985:KLLA0_A09185g ^@ http://purl.uniprot.org/uniprot/A0A5P2TZV4 ^@ Similarity ^@ Belongs to the enolase family. http://togogenome.org/gene/28985:KLLA0_D14311g ^@ http://purl.uniprot.org/uniprot/A0A5P2U669 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/28985:KLLA0_E06843g ^@ http://purl.uniprot.org/uniprot/A0A5P2UDR1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/28985:KLLA0_C02035g ^@ http://purl.uniprot.org/uniprot/B1B6P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family.|||Cytoplasm|||Membrane http://togogenome.org/gene/28985:KLLA0_B14883g ^@ http://purl.uniprot.org/uniprot/X5D4M1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 2 family. http://togogenome.org/gene/28985:KLLA0_F16555g ^@ http://purl.uniprot.org/uniprot/A0A5P2UAG0 ^@ Cofactor|||Subcellular Location Annotation ^@ Binds 1 heme c group covalently per subunit.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/28985:KLLA0_B11836g ^@ http://purl.uniprot.org/uniprot/A0A5P2UGD6 ^@ Function|||Similarity ^@ Belongs to the peptidase T1A family.|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. http://togogenome.org/gene/28985:KLLA0_F18568g ^@ http://purl.uniprot.org/uniprot/Q70W34 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/28985:KLLA0_D16676g ^@ http://purl.uniprot.org/uniprot/A0A5P2UEA8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/28985:KLLA0_F21604g ^@ http://purl.uniprot.org/uniprot/A0A5P2U689 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GAR1 family.|||Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.|||nucleolus http://togogenome.org/gene/28985:KLLA0_E02685g ^@ http://purl.uniprot.org/uniprot/Q7ZA18 ^@ Similarity ^@ In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. http://togogenome.org/gene/28985:KLLA0_E12211g ^@ http://purl.uniprot.org/uniprot/A0A5P2U1U0 ^@ Subcellular Location Annotation|||Subunit ^@ Component of the mitochondrial large ribosomal subunit.|||Mitochondrion http://togogenome.org/gene/28985:KLLA0_D00902g ^@ http://purl.uniprot.org/uniprot/A0A5P2U6G1 ^@ Similarity ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. http://togogenome.org/gene/28985:KLLA0_E01145g ^@ http://purl.uniprot.org/uniprot/A0A5P2UC65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Membrane http://togogenome.org/gene/28985:KLLA0_F09207g ^@ http://purl.uniprot.org/uniprot/A0A5P2U1F4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||Nucleus http://togogenome.org/gene/28985:KLLA0_A00616g ^@ http://purl.uniprot.org/uniprot/Q9Y854 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Component of the 60S subunit of the ribosome.|||Cytoplasm|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Nucleus|||Part of the 60S ribosomal subunit. http://togogenome.org/gene/28985:KLLA0_B13904g ^@ http://purl.uniprot.org/uniprot/A0A5P2U721 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/28985:KLLA0_E19185g ^@ http://purl.uniprot.org/uniprot/Q875N1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28985:KLLA0_B02266g ^@ http://purl.uniprot.org/uniprot/A0A5P2U9R7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NIP7 family.|||Interacts with pre-ribosome complex.|||Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/28985:KLLA0_B06622g ^@ http://purl.uniprot.org/uniprot/Q7Z8M5 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/28985:KLLA0_D16170g ^@ http://purl.uniprot.org/uniprot/A0A5P2U876 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/28985:KLLA0_E03279g ^@ http://purl.uniprot.org/uniprot/A0A5P2UEB5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/28985:KLLA0_D03212g ^@ http://purl.uniprot.org/uniprot/A0A5P2UCL1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL12 family. http://togogenome.org/gene/28985:KLLA0_C15895g ^@ http://purl.uniprot.org/uniprot/A0A5P2U3U2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.|||Nucleus http://togogenome.org/gene/28985:KLLA0_C09152g ^@ http://purl.uniprot.org/uniprot/B1B6P8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Sterol O-acyltransferase that catalyzes the formation of stery esters. http://togogenome.org/gene/28985:KLLA0_B07997g ^@ http://purl.uniprot.org/uniprot/A0A5P2UE46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT4 family.|||Nucleus|||The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.|||centromere http://togogenome.org/gene/28985:KLLA0_A05027g ^@ http://purl.uniprot.org/uniprot/A0A5P2TZC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. http://togogenome.org/gene/28985:KLLA0_E15093g ^@ http://purl.uniprot.org/uniprot/A0A5P2U828 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/28985:KLLA0_E06205g ^@ http://purl.uniprot.org/uniprot/A0A5P2UBM2 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/28985:KLLA0_A04213g ^@ http://purl.uniprot.org/uniprot/A0A5P2U081 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/28985:KLLA0_E17359g ^@ http://purl.uniprot.org/uniprot/A0A5P2U7T5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/28985:KLLA0_A02497g ^@ http://purl.uniprot.org/uniprot/A0A5P2U0D0 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/28985:KLLA0_B11231g ^@ http://purl.uniprot.org/uniprot/Q875M3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/28985:KLLA0_F09141g ^@ http://purl.uniprot.org/uniprot/Q8J0C9 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/28985:KLLA0_A05731g ^@ http://purl.uniprot.org/uniprot/A0A5P2U6T6 ^@ Function|||Similarity ^@ ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.|||Belongs to the DEAD box helicase family. eIF4A subfamily. http://togogenome.org/gene/28985:KLLA0_E02575g ^@ http://purl.uniprot.org/uniprot/A0A5P2UD10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/28985:KLLA0_E16391g ^@ http://purl.uniprot.org/uniprot/A0A5P2U9X3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF beta-subunit/FixA family.|||Binds 1 AMP per subunit.|||Binds 1 FAD per dimer.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/28985:KLLA0_B07931g ^@ http://purl.uniprot.org/uniprot/A0A5P2U904 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/28985:KLLA0_E14785g ^@ http://purl.uniprot.org/uniprot/Q8J0L2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/28985:KLLA0_B03289g ^@ http://purl.uniprot.org/uniprot/A0A5P2U9V8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fungal cytochrome c oxidase subunit 7a family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/28985:KLLA0_E21979g ^@ http://purl.uniprot.org/uniprot/A0A5P2U8A6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/28985:KLLA0_F09603g ^@ http://purl.uniprot.org/uniprot/A0A5P2U2F6 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/28985:KLLA0_F00968g ^@ http://purl.uniprot.org/uniprot/A0A5P2U023 ^@ Similarity ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family. http://togogenome.org/gene/28985:KLLA0_C17600g ^@ http://purl.uniprot.org/uniprot/A0A5P2U459 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/28985:KLLA0_F12100g ^@ http://purl.uniprot.org/uniprot/A0A5P2U970 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/28985:KLLA0_E17337g ^@ http://purl.uniprot.org/uniprot/A0A5P2U7S5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/28985:KLLA0_E13201g ^@ http://purl.uniprot.org/uniprot/A0A5P2U8A4 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/28985:KLLA0_C14872g ^@ http://purl.uniprot.org/uniprot/A0A5P2U2P5 ^@ Function|||Subcellular Location Annotation ^@ Acts as component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA.|||Nucleus http://togogenome.org/gene/28985:KLLA0_E02289g ^@ http://purl.uniprot.org/uniprot/A0A5P2UC61 ^@ Function|||Similarity|||Subunit ^@ Belongs to the profilin family.|||Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.|||Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio. http://togogenome.org/gene/28985:KLLA0_F12364g ^@ http://purl.uniprot.org/uniprot/A0A5P2U3I5 ^@ Similarity ^@ Belongs to the acetolactate synthase small subunit family. http://togogenome.org/gene/28985:KLLA0_E15731g ^@ http://purl.uniprot.org/uniprot/A0A5P2U7Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Mitochondrion inner membrane http://togogenome.org/gene/28985:KLLA0_E05127g ^@ http://purl.uniprot.org/uniprot/A0A5P2UCP6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/28985:KLLA0_F06831g ^@ http://purl.uniprot.org/uniprot/Q8J287 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/28985:KLLA0_E16941g ^@ http://purl.uniprot.org/uniprot/O94228 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SKP1 family.|||Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.|||Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/28985:KLLA0_C08723g ^@ http://purl.uniprot.org/uniprot/Q9P8T4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC12 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER. http://togogenome.org/gene/28985:KLLA0_C11737g ^@ http://purl.uniprot.org/uniprot/A0A5P2U342 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/28985:KLLA0_C01111g ^@ http://purl.uniprot.org/uniprot/Q9URT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/28985:KLLA0_E00573g ^@ http://purl.uniprot.org/uniprot/A0A5P2UD85 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Component of the ribosome. http://togogenome.org/gene/28985:KLLA0_A10153g ^@ http://purl.uniprot.org/uniprot/A0A5P2U0W1 ^@ Function|||Similarity ^@ Belongs to the peptidase T1A family.|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. http://togogenome.org/gene/28985:KLLA0_C05632g ^@ http://purl.uniprot.org/uniprot/A0A5P2U3V8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/28985:KLLA0_C05654g ^@ http://purl.uniprot.org/uniprot/A0A5P2U3V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/28985:KLLA0_E22199g ^@ http://purl.uniprot.org/uniprot/A0A5P2U8B5 ^@ Function|||PTM|||Similarity ^@ Belongs to the eIF-5A family.|||Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group. http://togogenome.org/gene/28985:KLLA0_F12001g ^@ http://purl.uniprot.org/uniprot/A0A5P2U1Q5 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/28985:KLLA0_D04224g ^@ http://purl.uniprot.org/uniprot/A0A5P2UCQ1 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/28985:KLLA0_D12144g ^@ http://purl.uniprot.org/uniprot/A0A5P2UDP7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/28985:KLLA0_C04389g ^@ http://purl.uniprot.org/uniprot/A0A5P2U914 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Fibrillarin family. http://togogenome.org/gene/28985:KLLA0_F10043g ^@ http://purl.uniprot.org/uniprot/Q701Q9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28985:KLLA0_F06853g ^@ http://purl.uniprot.org/uniprot/Q8J289 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/28985:KLLA0_C15345g ^@ http://purl.uniprot.org/uniprot/A0A5P2U4J6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/28985:KLLA0_E20461g ^@ http://purl.uniprot.org/uniprot/A0A5P2U7E4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS8 family. http://togogenome.org/gene/28985:KLLA0_A04037g ^@ http://purl.uniprot.org/uniprot/A0A5P2U088 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/28985:KLLA0_E05545g ^@ http://purl.uniprot.org/uniprot/A0A5P2UBQ4 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/28985:KLLA0_A02673g ^@ http://purl.uniprot.org/uniprot/A0A5P2U1J8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Mitochondrion http://togogenome.org/gene/28985:KLLA0_E22793g ^@ http://purl.uniprot.org/uniprot/A0A5P2U750 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/28985:KLLA0_B11473g ^@ http://purl.uniprot.org/uniprot/A0A5P2U8I0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/28985:KLLA0_C10549g ^@ http://purl.uniprot.org/uniprot/Q7ZA58 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/28985:KLLA0_F04037g ^@ http://purl.uniprot.org/uniprot/A0A5P2U0R1 ^@ Function|||Similarity ^@ Belongs to the beta-class carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/28985:KLLA0_F18546g ^@ http://purl.uniprot.org/uniprot/Q70W35 ^@ Similarity|||Subunit ^@ Belongs to the aerobic coproporphyrinogen-III oxidase family.|||Homodimer. http://togogenome.org/gene/28985:KLLA0_B02783g ^@ http://purl.uniprot.org/uniprot/A0A5P2UEX2 ^@ Function|||Similarity ^@ 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).|||Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/28985:KLLA0_C16753g ^@ http://purl.uniprot.org/uniprot/A0A5P2UAI9 ^@ Similarity ^@ Belongs to the NOP10 family. http://togogenome.org/gene/28985:KLLA0_E15071g ^@ http://purl.uniprot.org/uniprot/A0A5P2U820 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/28985:KLLA0_F14707g ^@ http://purl.uniprot.org/uniprot/A0A5P2UAN0 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/28985:KLLA0_E15995g ^@ http://purl.uniprot.org/uniprot/A0A5P2U7Y2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/28985:KLLA0_C03091g ^@ http://purl.uniprot.org/uniprot/Q707Z2 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/28985:KLLA0_E03829g ^@ http://purl.uniprot.org/uniprot/A0A5P2UCT9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28985:KLLA0_A02299g ^@ http://purl.uniprot.org/uniprot/A0A5P2U5C8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.|||Nucleus http://togogenome.org/gene/28985:KLLA0_D04444g ^@ http://purl.uniprot.org/uniprot/Q7Z864 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/28985:KLLA0_C03850g ^@ http://purl.uniprot.org/uniprot/A0A5P2UBR5 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/28985:KLLA0_A09207g ^@ http://purl.uniprot.org/uniprot/A0A5P2U765 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Membrane http://togogenome.org/gene/28985:KLLA0_F08228g ^@ http://purl.uniprot.org/uniprot/A0A5P2U8R9 ^@ Subunit ^@ The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. http://togogenome.org/gene/28985:KLLA0_C08107g ^@ http://purl.uniprot.org/uniprot/A0A5P2UB68 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.|||Can also use Mn(2+) ion. http://togogenome.org/gene/28985:KLLA0_D19514g ^@ http://purl.uniprot.org/uniprot/A0A5P2U6U1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SSU72 phosphatase family.|||Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.|||Component of the cleavage and polyadenylation factor (CPF) complex.|||Nucleus|||Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). http://togogenome.org/gene/28985:KLLA0_E05875g ^@ http://purl.uniprot.org/uniprot/A0A5P2UBL5 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/28985:KLLA0_A04499g ^@ http://purl.uniprot.org/uniprot/A0A5P2U1M2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ran family.|||GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.|||Nucleus http://togogenome.org/gene/28985:KLLA0_F08767g ^@ http://purl.uniprot.org/uniprot/A0A5P2U1C9 ^@ Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B family. http://togogenome.org/gene/28985:KLLA0_A05797g ^@ http://purl.uniprot.org/uniprot/A0A5P2U0G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/28985:KLLA0_B13563g ^@ http://purl.uniprot.org/uniprot/A0A5P2U327 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the pre-60S ribosomal particle.|||Belongs to the universal ribosomal protein uL10 family.|||Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.|||Cytoplasm|||nucleolus http://togogenome.org/gene/28985:KLLA0_C05478g ^@ http://purl.uniprot.org/uniprot/A0A5P2U521 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/28985:KLLA0_F09185g ^@ http://purl.uniprot.org/uniprot/Q96WL4 ^@ Similarity ^@ Belongs to the Rab GDI family. http://togogenome.org/gene/28985:KLLA0_C12815g ^@ http://purl.uniprot.org/uniprot/A0A5P2UAL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. http://togogenome.org/gene/28985:KLLA0_E01453g ^@ http://purl.uniprot.org/uniprot/A0A5P2UEJ0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/28985:KLLA0_B12826g ^@ http://purl.uniprot.org/uniprot/A0A5P2U1W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/28985:KLLA0_F22220g ^@ http://purl.uniprot.org/uniprot/Q874T9 ^@ Similarity ^@ Belongs to the glycosyltransferase 32 family. http://togogenome.org/gene/28985:KLLA0_A06149g ^@ http://purl.uniprot.org/uniprot/A0A5P2TZK6 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/28985:KLLA0_F11957g ^@ http://purl.uniprot.org/uniprot/A0A5P2U2S9 ^@ Similarity ^@ Belongs to the RecA family. DMC1 subfamily. http://togogenome.org/gene/28985:KLLA0_C18931g ^@ http://purl.uniprot.org/uniprot/Q874B4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/28985:KLLA0_E11287g ^@ http://purl.uniprot.org/uniprot/A0A5P2UIT0 ^@ Similarity ^@ Belongs to the eIF-1A family. http://togogenome.org/gene/28985:KLLA0_D17204g ^@ http://purl.uniprot.org/uniprot/A0A5P2UAX2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF10 family.|||Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation), facilitation of DNA opening and initiation of transcription. SAGA is required for recruitment of the basal transcription machinery. SLIK is proposed to have partly overlapping functions with SAGA.|||Nucleus http://togogenome.org/gene/28985:KLLA0_C05126g ^@ http://purl.uniprot.org/uniprot/A0A5P2U1M2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ran family.|||GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.|||Nucleus http://togogenome.org/gene/28985:KLLA0_F01683g ^@ http://purl.uniprot.org/uniprot/A0A5P2TZ34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL54 family.|||Mitochondrion http://togogenome.org/gene/28985:KLLA0_F12496g ^@ http://purl.uniprot.org/uniprot/A0A5P2U1S6 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/28985:KLLA0_A11858g ^@ http://purl.uniprot.org/uniprot/A0A5P2U2D5 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/28985:KLLA0_A06798g ^@ http://purl.uniprot.org/uniprot/A0A5P2TZH8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/28985:KLLA0_B01562g ^@ http://purl.uniprot.org/uniprot/A0A5P2UAN9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS13 family. http://togogenome.org/gene/28985:KLLA0_D04400g ^@ http://purl.uniprot.org/uniprot/A0A5P2U518 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase F subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.|||Vacuole membrane http://togogenome.org/gene/28985:KLLA0_D10659g ^@ http://purl.uniprot.org/uniprot/A0A5P2U5T0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/28985:KLLA0_B12078g ^@ http://purl.uniprot.org/uniprot/A0A5P2U8F9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/28985:KLLA0_A01903g ^@ http://purl.uniprot.org/uniprot/A0A5P2U0A7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/28985:KLLA0_C11957g ^@ http://purl.uniprot.org/uniprot/A0A5P2U331 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28985:KLLA0_C14652g ^@ http://purl.uniprot.org/uniprot/A0A5P2U2N7 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/28985:KLLA0_E04555g ^@ http://purl.uniprot.org/uniprot/A0A5P2UH09 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS18 family. http://togogenome.org/gene/28985:KLLA0_C18546g ^@ http://purl.uniprot.org/uniprot/Q9P892 ^@ Similarity ^@ Belongs to the TRM112 family. http://togogenome.org/gene/28985:KLLA0_F00352g ^@ http://purl.uniprot.org/uniprot/A0A5P2UDV3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/28985:KLLA0_E06293g ^@ http://purl.uniprot.org/uniprot/A0A5P2UCH9 ^@ Similarity|||Subunit ^@ Belongs to the glutamine synthetase family.|||Homooctamer. http://togogenome.org/gene/28985:KLLA0_C08327g ^@ http://purl.uniprot.org/uniprot/A0A5P2U4J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PET117 family.|||Mitochondrion http://togogenome.org/gene/28985:KLLA0_C15961g ^@ http://purl.uniprot.org/uniprot/Q8J2P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Membrane http://togogenome.org/gene/28985:KLLA0_E20373g ^@ http://purl.uniprot.org/uniprot/A0A5P2U8J6 ^@ Function|||Similarity ^@ 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).|||Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/28985:KLLA0_C06138g ^@ http://purl.uniprot.org/uniprot/A0A5P2U3T4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/28985:KLLA0_E22529g ^@ http://purl.uniprot.org/uniprot/A0A5P2UF01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/28985:KLLA0_F15532g ^@ http://purl.uniprot.org/uniprot/A0A5P2UBH6 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/28985:KLLA0_B04048g ^@ http://purl.uniprot.org/uniprot/A0A5P2UAX6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/28985:KLLA0_E22441g ^@ http://purl.uniprot.org/uniprot/A0A5P2UBK7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.|||Vacuole membrane http://togogenome.org/gene/28985:KLLA0_E21627g ^@ http://purl.uniprot.org/uniprot/Q6HA25 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/28985:KLLA0_E22661g ^@ http://purl.uniprot.org/uniprot/A0A5P2U770 ^@ Similarity ^@ Belongs to the PET191 family. http://togogenome.org/gene/28985:KLLA0_F25542g ^@ http://purl.uniprot.org/uniprot/A0A5P2U0T9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS10 family. http://togogenome.org/gene/28985:KLLA0_D08580g ^@ http://purl.uniprot.org/uniprot/A0A5P2UD88 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/28985:KLLA0_C16775g ^@ http://purl.uniprot.org/uniprot/A0A5P2U3X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DASH complex DAD4 family.|||Nucleus|||kinetochore|||spindle http://togogenome.org/gene/28985:KLLA0_B08910g ^@ http://purl.uniprot.org/uniprot/A0A5P2UB05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.|||Nucleus http://togogenome.org/gene/28985:KLLA0_B03311g ^@ http://purl.uniprot.org/uniprot/A0A5P2UHT6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIc family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/28985:KLLA0_B05060g ^@ http://purl.uniprot.org/uniprot/A0A5P2UH82 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).|||Cytoplasm http://togogenome.org/gene/28985:KLLA0_D19294g ^@ http://purl.uniprot.org/uniprot/Q01073 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RAP1 family.|||Homodimer.|||Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).|||Nucleus|||telomere http://togogenome.org/gene/28985:KLLA0_E08647g ^@ http://purl.uniprot.org/uniprot/A0A5P2UC44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/28985:KLLA0_A09339g ^@ http://purl.uniprot.org/uniprot/Q875M5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Homodimer. http://togogenome.org/gene/28985:KLLA0_D14861g ^@ http://purl.uniprot.org/uniprot/A0A5P2UAM3 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/28985:KLLA0_B03377g ^@ http://purl.uniprot.org/uniprot/A0A5P2UAW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins. http://togogenome.org/gene/28985:KLLA0_B08998g ^@ http://purl.uniprot.org/uniprot/A0A5P2UD61 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/28985:KLLA0_D18502g ^@ http://purl.uniprot.org/uniprot/A0A5P2U7P5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.|||Nucleus http://togogenome.org/gene/28985:KLLA0_F17281g ^@ http://purl.uniprot.org/uniprot/A0A5P2UEQ9 ^@ Function|||Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. http://togogenome.org/gene/28985:KLLA0_D04840g ^@ http://purl.uniprot.org/uniprot/A0A5P2U656 ^@ Similarity ^@ Belongs to the WD repeat LST8 family. http://togogenome.org/gene/28985:KLLA0_E18635g ^@ http://purl.uniprot.org/uniprot/A0A5P2U9G4 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/28985:KLLA0_E20813g ^@ http://purl.uniprot.org/uniprot/Q96UG3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/28985:KLLA0_F09075g ^@ http://purl.uniprot.org/uniprot/A0A5P2U8V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 6A family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/28985:KLLA0_B10648g ^@ http://purl.uniprot.org/uniprot/A0A5P2UAZ8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/28985:KLLA0_E12453g ^@ http://purl.uniprot.org/uniprot/A0A5P2U8D8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL19 family. http://togogenome.org/gene/28985:KLLA0_C05918g ^@ http://purl.uniprot.org/uniprot/A0A5P2U3U6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/28985:KLLA0_E13619g ^@ http://purl.uniprot.org/uniprot/A0A5P2UDE8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.|||nucleolus http://togogenome.org/gene/28985:KLLA0_D03652g ^@ http://purl.uniprot.org/uniprot/Q9P4W5 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/28985:KLLA0_E10847g ^@ http://purl.uniprot.org/uniprot/A0A5P2UAZ6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/28985:KLLA0_B13277g ^@ http://purl.uniprot.org/uniprot/A0A5P2U2Y0 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/28985:KLLA0_D08008g ^@ http://purl.uniprot.org/uniprot/A0A5P2U5F7 ^@ Similarity ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. http://togogenome.org/gene/28985:KLLA0_D02992g ^@ http://purl.uniprot.org/uniprot/A0A5P2U5Y7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the calcineurin regulatory subunit family.|||Composed of a catalytic subunit (A) and a regulatory subunit (B).|||Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. http://togogenome.org/gene/28985:KLLA0_E18217g ^@ http://purl.uniprot.org/uniprot/A0A5P2U7P1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARPC4 family.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.|||actin patch http://togogenome.org/gene/28985:KLLA0_B02046g ^@ http://purl.uniprot.org/uniprot/A0A5P2U9R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. SAR1 family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/28985:KLLA0_E05567g ^@ http://purl.uniprot.org/uniprot/A0A5P2UFZ6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/28985:KLLA0_B02002g ^@ http://purl.uniprot.org/uniprot/A0A5P2UAR6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/28985:KLLA0_E05435g ^@ http://purl.uniprot.org/uniprot/A0A5P2UBN6 ^@ Function|||Similarity ^@ Belongs to the transferase hexapeptide repeat family.|||Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint. http://togogenome.org/gene/28985:KLLA0_D14641g ^@ http://purl.uniprot.org/uniprot/A0A5P2UBC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/28985:KLLA0_E19823g ^@ http://purl.uniprot.org/uniprot/A0A5P2U8L8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/28985:KLLA0_F12518g ^@ http://purl.uniprot.org/uniprot/A0A5P2U1S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/28985:KLLA0_F04103g ^@ http://purl.uniprot.org/uniprot/A0A5P2U868 ^@ Similarity|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Octamer of two non-identical subunits IDH1 and IDH2. http://togogenome.org/gene/28985:KLLA0_C06336g ^@ http://purl.uniprot.org/uniprot/Q53IY3 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/28985:KLLA0_D00979g ^@ http://purl.uniprot.org/uniprot/A0A3G9K911 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/28985:KLLA0_E03917g ^@ http://purl.uniprot.org/uniprot/A0A5P2UH37 ^@ Function|||Similarity ^@ Belongs to the peptidase T1A family.|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. http://togogenome.org/gene/28985:KLLA0_F09449g ^@ http://purl.uniprot.org/uniprot/A0A5P2U6F6 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/28985:KLLA0_E18261g ^@ http://purl.uniprot.org/uniprot/A0A5P2UC18 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.|||Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/28985:KLLA0_F04323g ^@ http://purl.uniprot.org/uniprot/A0A5P2U0R8 ^@ Similarity ^@ Belongs to the WrbA family. http://togogenome.org/gene/28985:KLLA0_E21891g ^@ http://purl.uniprot.org/uniprot/Q53IY2 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/28985:KLLA0_D05115g ^@ http://purl.uniprot.org/uniprot/A0A5P2U547 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family.|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. http://togogenome.org/gene/28985:KLLA0_D13640g ^@ http://purl.uniprot.org/uniprot/A0A5P2UDX7 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/28985:KLLA0_E07987g ^@ http://purl.uniprot.org/uniprot/A0A5P2UBC7 ^@ Similarity|||Subunit ^@ Belongs to the AlaDH/PNT family.|||Monomer. http://togogenome.org/gene/28985:KLLA0_F08261g ^@ http://purl.uniprot.org/uniprot/A0A5P2U2A1 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL5 family.|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. http://togogenome.org/gene/28985:KLLA0_D13508g ^@ http://purl.uniprot.org/uniprot/A0A5P2UAH4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/28985:KLLA0_B13321g ^@ http://purl.uniprot.org/uniprot/A0A5P2U495 ^@ Function|||Similarity ^@ Belongs to the APS kinase family.|||Catalyzes the synthesis of activated sulfate. http://togogenome.org/gene/28985:KLLA0_C16643g ^@ http://purl.uniprot.org/uniprot/A0A5P2U2X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Membrane|||nuclear pore complex http://togogenome.org/gene/28985:KLLA0_E01981g ^@ http://purl.uniprot.org/uniprot/A0A5P2UC40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Nucleus http://togogenome.org/gene/28985:KLLA0_E05941g ^@ http://purl.uniprot.org/uniprot/A0A5P2UGU9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/28985:KLLA0_F16511g ^@ http://purl.uniprot.org/uniprot/A0A5P2UFM2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/28985:KLLA0_F10637g ^@ http://purl.uniprot.org/uniprot/A0A5P2U3B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DASH complex DAD3 family.|||Nucleus|||kinetochore|||spindle http://togogenome.org/gene/28985:KLLA0_D06699g ^@ http://purl.uniprot.org/uniprot/A0A5P2UD05 ^@ Similarity ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family. http://togogenome.org/gene/28985:KLLA0_C18216g ^@ http://purl.uniprot.org/uniprot/A0A5P2U3E8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family.