http://togogenome.org/gene/2961896:NK667_RS27290                                                                                  ^@                                                                                  http://purl.uniprot.org/uniprot/D7RJY3                                                                                  ^@                                                                                  Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit                                                                                  ^@                                                                                  A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.
http://togogenome.org/gene/2961896:NK667_RS21255                                                                                  ^@                                                                                  http://purl.uniprot.org/uniprot/D7RJY0                                                                                  ^@                                                                                  Function|||Similarity|||Subcellular Location Annotation                                                                                  ^@                                                                                  Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm
http://togogenome.org/gene/2961896:NK667_RS30355                                                                                  ^@                                                                                  http://purl.uniprot.org/uniprot/D7RJY1                                                                                  ^@                                                                                  Function|||Similarity|||Subcellular Location Annotation|||Subunit                                                                                  ^@                                                                                  Belongs to the sigma-70 factor family. RpoD/SigA subfamily.|||Cytoplasm|||Interacts transiently with the RNA polymerase catalytic core.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
http://togogenome.org/gene/2961896:NK667_RS26970                                                                                  ^@                                                                                  http://purl.uniprot.org/uniprot/D7RJX9                                                                                  ^@                                                                                  Similarity|||Subcellular Location Annotation                                                                                  ^@                                                                                  Belongs to the thioredoxin family. DsbA subfamily.|||Periplasm